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Information on EC 3.1.4.38 - glycerophosphocholine cholinephosphodiesterase and Organism(s) Homo sapiens

for references in articles please use BRENDA:EC3.1.4.38
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EC Tree
IUBMB Comments
No activity on sn-3-glycerophosphoethanolamine.
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This record set is specific for:
Homo sapiens
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The taxonomic range for the selected organisms is: Homo sapiens
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
glycerophosphocholine cholinephosphodiesterase, gpc-cpde, glycerophosphocholine choline phosphodiesterase, gpc-cp, l-3-glycerylphosphinicocholine cholinephosphohydrolase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Co2+-glycerophosphocholine cholinphosphodiesterase
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-
-
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L-3-glycerylphosphinicocholine cholinephosphohydrolase
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-
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p-nitrophenylphosphocholine cholinphosphodiesterase
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-
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Zn2+-glycerophosphocholine cholinphosphodiesterase
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Zn2+-GPC cholinphosphodiesterase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of phosphoric ester
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SYSTEMATIC NAME
IUBMB Comments
sn-glycero-3-phosphocholine cholinephosphohydrolase
No activity on sn-3-glycerophosphoethanolamine.
CAS REGISTRY NUMBER
COMMENTARY hide
60063-78-7
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
sn-glycero-3-phosphocholine + H2O
glycerol + choline phosphate
show the reaction diagram
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r
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
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autopsy of nonaffected white matter and Multiple sclerosis plaques
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
-
myelin
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
ENPP6_HUMAN
440
0
50241
Swiss-Prot
Secretory Pathway (Reliability: 1)
D6R9P1_HUMAN
194
0
22348
TrEMBL
other Location (Reliability: 2)
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Janzen, L.; Tourtellotte, W.W.; Kanfer J.N.
Glycerylphosphocholine phosphocholine phosphodiesterase activity is reduced in multiple sclerosis plaques
Exp. Neurol.
109
243-246
1990
Homo sapiens
Manually annotated by BRENDA team