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Information on EC 3.1.4.17 - 3',5'-cyclic-nucleotide phosphodiesterase and Organism(s) Rattus norvegicus
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3.1.4.17 3',5'-cyclic-nucleotide phosphodiesteraseIUBMB Comments
Acts on 3',5'-cyclic AMP, 3',5'-cyclic dAMP, 3',5'-cyclic IMP, 3',5'-cyclic GMP and 3',5'-cyclic CMP.
Specify your search results
Word Map
- 3.1.4.17
- cyclase
- adenylate
- rolipram
- cardiac
- artery
- pka
- guanosine
- agonist
-
camp-dependent
- forskolin
- ibmx
-
contractile
-
adenylyl
- theophylline
- milrinone
- cilostazol
- platelet
- isoproterenol
- prostaglandin
- striatal
-
schizophrenia
- 3-isobutyl-1-methylxanthine
-
vasodilator
- zaprinast
- papaverine
-
inotropic
- dipyridamole
-
spiny
-
camp-mediated
-
beta-adrenergic
-
guanylyl
- sildenafil
- 3',5'-monophosphate
-
prkar1a
-
cardiotonic
- phosphodiesterase-4
- amrinone
- isobutylmethylxanthine
- trifluoperazine
- isoprenaline
-
bronchodilator
- methylxanthines
-
low-km
-
antilipolytic
- ehna
- aminophylline
- roflumilast
- molecular biology
- vardenafil
- medicine
- tadalafil
-
camp-elevating
The taxonomic range for the selected organisms is: Rattus norvegicus
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
pde4d, cyclic nucleotide phosphodiesterase, pde10a, camp phosphodiesterase, pde3a, pde3b, pde2a, camp-pde, phosphodiesterase 3, pde11a, 
more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
3',5'-cyclic nucleoside monophosphate phosphodiesterase
-
-
-
-
3',5'-cyclonucleotide phosphodiesterase
-
-
-
-
3',5'-nucleotide phosphodiesterase
-
-
-
-
3':5'-CNP
-
-
-
-
3':5'-cyclic nucleotide 5'-nucleotidohydrolase
-
-
-
-
61 kDa Cam-PDE
-
-
-
-
63 kDa Cam-PDE
-
-
-
-
Cam-PDE 1A
-
-
-
-
Cam-PDE 1B
-
-
-
-
Cam-PDE 1C
-
-
-
-
CGB-PDE
-
-
-
-
CGIP1
-
-
-
-
CGIPDE1
-
-
-
-
cGMP-binding cGMP-specific phosphodiesterase
-
-
-
-
CGS-PDE
-
-
-
-
cGSPDE
-
-
-
-
cyclic 3',5'-mononucleotide phosphodiesterase
-
-
-
-
cyclic 3',5'-nucleotide phosphodiesterase
-
-
-
-
cyclic 3',5'-phosphodiesterase
-
-
-
-
cyclic 3',5-nucleotide monophosphate phosphodiesterase
-
-
-
-
Cyclic GMP stimulated phosphodiesterase
-
-
-
-
cyclic nucleotide phosphodiesterase
-
-
-
-
DPDE1
-
-
-
-
DPDE2
-
-
-
-
DPDE3
-
-
-
-
DPDE4
-
-
-
-
Dunce protein
-
-
-
-
GMP-PDE alpha
-
-
-
-
GMP-PDE beta
-
-
-
-
GMP-PDE delta
-
-
-
-
GMP-PDE gamma
-
-
-
-
HCP1
-
-
-
-
High-affinity cAMP phosphodiesterase
-
-
-
-
Learning/ memory process protein
-
-
-
-
Low-affinity cAMP phosphodiesterase
-
-
-
-
MMPDE8
-
-
-
-
nucleoside 3',5'-cyclic phosphate diesterase
-
-
-
-
nucleoside-3',5-monophosphate phosphodiesterase
-
-
-
-
p17 protein
-
-
-
-
P2A
-
-
-
-
PDE V-B1
-
-
-
-
PDE V-C1
-
-
-
-
PDE10A
PDE21
-
-
-
-
PDE32
-
-
-
-
PDE43
-
-
-
-
PDE46
-
-
-
-
PDEase
-
-
-
-
PDEase regA
-
-
-
-
phosphodiesterase, cyclic 3',5'-nucleotide
-
-
-
-
TM22
-
-
-
-
PDE10A
-
hydrolyses both 3',5'-cAMP and 3',5'-cGMP although with different kinetic parameters
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of phosphoric ester
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
3',5'-cyclic-nucleotide 5'-nucleotidohydrolase
Acts on 3',5'-cyclic AMP, 3',5'-cyclic dAMP, 3',5'-cyclic IMP, 3',5'-cyclic GMP and 3',5'-cyclic CMP.
CAS REGISTRY NUMBER
COMMENTARY
9040-59-9
-
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
3',5'-cAMP + H2O
5'-AMP
-
-
-
-
?
3',5'-cGMP + H2O
5'-GMP
-
-
-
-
?
3',5'-cGMP + H2O
5'-GMP
-
the technique can be used to measure Ca2+/CaM-stimulated PDE activity in cultured cells or tissues
-
-
?
nucleoside 3',5'-cyclic phosphate + H2O
nucleoside 5'-phosphate
-
-
-
?
nucleoside 3',5'-cyclic phosphate + H2O
nucleoside 5'-phosphate
-
-
-
?
nucleoside 3',5'-cyclic phosphate + H2O
nucleoside 5'-phosphate
-
-
-
?
nucleoside 3',5'-cyclic phosphate + H2O
nucleoside 5'-phosphate
-
-
-
?
nucleoside 3',5'-cyclic phosphate + H2O
nucleoside 5'-phosphate
-
-
-
?
nucleoside 3',5'-cyclic phosphate + H2O
nucleoside 5'-phosphate
-
-
-
?
additional information
?
-
-
insulin-induced activation of the membrane bound PDE3B is a key step in insulin-mediated inhibition of lipolysis and is also involved in the regulation of insulin-mediated glucose uptake and lipogenesis in adipocytes
-
-
?
additional information
?
-
cGMP levels in the spinal cord are controlled by a number of enzyme isoforms, that can be present in the same cell. Role of NO-cGMP signaling in nociceptive processing
-
-
?
additional information
?
-
-
cytoplasmic isoform PDE1A regulates myosin light chain phosphorylation with little effect on apoptosis, whereas nuclear enzyme isoform PDE1A is important in vascular smoth muscle cell growth and survival
-
-
?
additional information
?
-
-
PDE10A regulates both cAMP and cGMP signaling cascades to impact early signal processing in the corticostriatothalamic circuit
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
-
-
insulin-induced activation of the membrane bound PDE3B is a key step in insulin-mediated inhibition of lipolysis and is also involved in the regulation of insulin-mediated glucose uptake and lipogenesis in adipocytes
-
-
?
additional information
?
-
cGMP levels in the spinal cord are controlled by a number of enzyme isoforms, that can be present in the same cell. Role of NO-cGMP signaling in nociceptive processing
-
-
?
additional information
?
-
-
cytoplasmic isoform PDE1A regulates myosin light chain phosphorylation with little effect on apoptosis, whereas nuclear enzyme isoform PDE1A is important in vascular smoth muscle cell growth and survival
-
-
?
additional information
?
-
-
PDE10A regulates both cAMP and cGMP signaling cascades to impact early signal processing in the corticostriatothalamic circuit
-
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Ca2+
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
2-[[4-[4-pyridin-4-yl-1-(2,2, 2-trifluoroethyl)pyrazol-3-yl]phenoxy]methyl]quinoline succinic acid
5-(3-cyclopentyloxy-4-methoxy-phenyl)-pyrrolidin-2-one
-
50% inhibition at about 0.1 mM
2-[[4-[4-pyridin-4-yl-1-(2,2, 2-trifluoroethyl)pyrazol-3-yl]phenoxy]methyl]quinoline succinic acid
-
potent inhibitor
2-[[4-[4-pyridin-4-yl-1-(2,2, 2-trifluoroethyl)pyrazol-3-yl]phenoxy]methyl]quinoline succinic acid
-
selective PDE10A inhibitor, inhibition of striatal PDE10A activity increases the responsiveness of medium-sized spiny projection neurons to depolarising stimuli
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
clozapine
-
chronic treatment with 20 mg/kg clozapine increases PDE10A expression by 62%
lipopolysaccharide
-
expression and activity of isoforms PDE2, PDE3, PDE11 in cultured peritoneal macrophages are recovered after treatment of cultured cells with lipopolysaccharide. Lipopolysaccharide also up-regulates enzyme expression in resident peritoneal macrophages
haloperidol
-
chronic treatment with 1 mg/kg haloperidol increases PDE10A expression by 118%
haloperidol
-
chronic treatment with 1 mg/kg haloperidol increases PDE10A expression by 65%
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.000001
2-[[4-[4-pyridin-4-yl-1-(2,2, 2-trifluoroethyl)pyrazol-3-yl]phenoxy]methyl]quinoline succinic acid
Rattus norvegicus
-
the IC50 of the compound for inhibition of PDE10A in vitro is less than 1 nM
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
additional information
-
description of a technique used to estimate the extent of PDE1 activation in vivo by measuring in vitro the PDE activity
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
-
PDE 1 vascular expression is increased in arteries from angiotensin II hypertensive rats
-
age-related increases in isoforms PDE11A4, PDE8A3, PDE8A4/5, and PDE1C1 protein expression are confirmed in hippocampus of old versus young rodents. Relative to young rats, the hippocampi of old rats demonstrate strikingly decreased phosphorylation of GluR1, CaMKIIalpha, and CaMKIIbeta, decreased expression of the transmembrane AMPA regulatory proteins gamma2 (a.k.a. stargazin) and gamma8, and increased trimethylation of H3K27. Expression of isoforms of PDE11A4, and PDE1C1 correlate with these functional endpoints in young but not old rats
-
in freshly isolated peritoneal exudate macrophage, isoforms PDE1, PDE2, PDE3, PDE10, PDE11 are expressed. After 24h of cultures, levels of isoforms PDE2, PDE3, and PDE11 are markedly decreased. Their expression and activity are recovered after treatment of cultured cells with lipopolysaccharide
-
splice variant PDE1A is distributed in outer retina, especially in the outer segments of photoreceptors. Variant PDE1B is uniformly distributed across the retina, PDE1C is confined mainly to the inner retina with precise localization to the inner nuclear layer
cervical spinal cord, expression of isoforms PDE2, PDE5, and PDE9 in all lamina, in ventral motor neurons and in ependymal cells lining the central canal. Study on the influence of enzyme activity on NO-stimulated cGMP levels
additional information
-
PDE10A is strongly expressed in the brain, highly expressed in striatal complex including caudate putamen, nucleus accumbens, and olfacory tubercle
-
isoforms PDE1B, PDE1C, PDE2A, PDE10A, and PDE11A show an age-related increase or decrease in mRNA expression in at least 1 of the 4 brain regions examined (hippocampus, cortex, striatum, and cerebellum). mRNA expression of isoforms PDE1A, PDE3A, PDE3B, PDE4B, and PDE9A does not change with age. Age-related increases in PDE11A4, and PDE1C1 protein expression are confirmed in hippocampus of old versus young rodents, as are age-related increases in PDE8A3 protein expression in the striatum
-
PDE10A is highly expressed in the medium spiny neurons of the striatum
-
PDE10A is highly expressed in striatal medium-sized spiny projection neurons
-
enzyme isoform PDE1A is predominantly cytoplasmic in medial contractile vascular smoth muscle cell and nuclear in neointimal synthetic vascular smoth muscle cell
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
-
enzyme isoform PDE1A is predominantly cytoplasmic in medial contractile vascular smoth muscle cell and nuclear in neointimal synthetic vascular smoth muscle cell. Nuclear enzyme isoform PDE1A is important in vascular smoth muscle cell growth and survival
-
enzyme isoform PDE1A is predominantly cytoplasmic in medial contractile vascular smoth muscle cell and nuclear in neointimal synthetic vascular smoth muscle cell. Cytoplasmic isoform PDE1A regulates myosin light chain phosphorylation with little effect on apoptosis
-
PDE10A is found almost exclusively in the membrane fraction
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
malfunction
-
phosphodiesterase-1 inhibition decreases vascular contraction in arteries from angiotensin II hypertensive, but not control, rats. The inhibition of PDE1 in smooth muscle cells isolated from normal aorta or from atherosclerotic lesions results in suppression of smooth muscle cell proliferation
physiological function
-
when Ca2 is high, PDE1 is activated, resulting in lower levels of cGMP, which theoretically facilitates the smooth muscle cell contraction
additional information
-
three different isoforms of calmodulin-dependent PDE isoforms are reported, PDE1A and PDE1B, which display higher affinity to hydrolyze cGMP compared to cAMP, and PDE1C, which has a similar ability to hydrolyze cGMP and cAMP
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). PDE10_RAT
794
0
90161
Swiss-Prot
other Location (Reliability: 2)
PDE2A_RAT
928
0
104664
Swiss-Prot
Secretory Pathway (Reliability: 2)
PDE3A_RAT
1141
5
124301
Swiss-Prot
other Location (Reliability: 3)
PDE3B_RAT
1108
5
123107
Swiss-Prot
other Location (Reliability: 2)
PDE1B_RAT
535
0
61260
Swiss-Prot
other Location (Reliability: 1)
PDE1C_RAT
768
0
86671
Swiss-Prot
other Location (Reliability: 2)
Q8VIE3_RAT
359
0
41456
TrEMBL
other Location (Reliability: 3)
PDB
SCOP
CATH
UNIPROT
ORGANISM
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
63000
-
x * 63000, splice variant PDE1B, x * 74000 and x * 70000, splice variant PDE1C, x * 79000, splice variant PDE1A
70000
-
x * 63000, splice variant PDE1B, x * 74000 and x * 70000, splice variant PDE1C, x * 79000, splice variant PDE1A
74000
79000
-
x * 63000, splice variant PDE1B, x * 74000 and x * 70000, splice variant PDE1C, x * 79000, splice variant PDE1A
74000
-
x * 63000, splice variant PDE1B, x * 74000 and x * 70000, splice variant PDE1C, x * 79000, splice variant PDE1A
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
?
-
x * 63000, splice variant PDE1B, x * 74000 and x * 70000, splice variant PDE1C, x * 79000, splice variant PDE1A
additional information
-
nuclear and cytoplasmic enzyme isoform PDE1A are associated with contractile marker SM-calponin and growth marker Ki-67, respectively
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
-
decrease in enzyme activity by RNAi results in significantly attenuated vascular smoth muscle cell growth by decreasing proliferation via G1 arrest and inducing apoptosis. Application of RNAi also leads to intracellular cGMP elevation, p27Kip1 upregulation, cyclin D1 downregulation, and p53 activation
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
angiotensin II is able to increase PDE1 expression in vascular smooth muscle cells
-
isoforms PDE1B, PDE1C, PDE2A, PDE4A, PDE4D, PDE5A, PDE7A, PDE8A, PDE8B, PDE10A, and PDE11A show an age-related increase or decrease in mRNA expression in at least 1 of the 4 brain regions examined (hippocampus, cortex, striatum, and cerebellum). mRNA expression of isoforms PDE1A, PDE3A, PDE3B, PDE4B, PDE7A, PDE7B, and PDE9A does not change with age
-
APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
medicine
molecular biology
medicine
-
enzyme inhibitors can reverse the time-dependent forgetting in the object recognition test. The efficacy of the different inhibitors is dependent on the time point of administration after acquisition. Support for a role for cGMP in early stages of memory formation and for cAMP in the late stages of memory formation
medicine
-
genetic disruption or pharmacological inhibition of PDE10A reverses behavioral abnormalities associated with subcortical hyperdopaminergia
medicine
-
inhibition of PDE10A represents an important new target for the treatment of schizophrenia and related disorders of basal ganglia function
medicine
-
PDE2 inhibition improved short-termobject recognition performance after an acute tryptophan depletion induced deficit
molecular biology
-
convenient and sensitive radioenzymatic assay for characterization and determining the contribution if the various PDE families in cell and tissue, PDE11
molecular biology
-
convenient and sensitive radioenzymatic assay for characterization and determining the contribution of the various PDE families in cell and tissue, PDE1
molecular biology
-
convenient and sensitive radioenzymatic assay for characterization and determining the contribution of the various PDE families in cell and tissue, PDE10
molecular biology
-
convenient and sensitive radioenzymatic assay for characterization and determining the contribution of the various PDE families in cell and tissue, PDE2
molecular biology
-
convenient and sensitive radioenzymatic assay for characterization and determining the contribution of the various PDE families in cell and tissue, PDE3
molecular biology
-
description of a technique used to estimate the extent of PDE1 activation in vivo by measuring in vitro the PDE activity. The technique can be used to measure Ca2+/CaM-stimulated PDE activity in cultured cells or tissues
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Purvis, K.; Rui, H.
High-affinity, calmodulin-dependent isoforms of cyclic nucleotide phosphodiesterase in rat testis
Methods Enzymol.
159
675-685
1988
Rattus norvegicus
Hansen, R.S.; Charbonneau, H.; Beavo, J.A.
Purification of calmodulin-stimulated cyclic nucleotide phosphodiesterase by monoclonal antibody affinity chromatography
Methods Enzymol.
159
543-557
1988
Bos taurus, Rattus norvegicus
Yan, C.; Zhao, A.Z.; Bentley, J.K.; Lougney, K.; Ferguson, K.; Beavo, J.A.
Molecular cloning and characterization of a calmodulin-dependent phosphodiesterase enriched in olfactory sensory neurons
Proc. Natl. Acad. Sci. USA
92
9677-9681
1995
Rattus norvegicus
Leroy, M.J.; Degerman, E.; Taira, M.; Murata, T.; Wang, L.H.; Movsesian, M.A.; Meacci, E.; Manganiello, V.C.
Characterization of two recombinant PDE3 (cGMP inhibited cyclic nucleotide phosphodiesterase) isoforms, RcGIP1 and HcGIP2, expressed in NIH 3006 murine fibroblasts and Sf9 insect cells
Biochemistry
35
10194-10202
1996
Homo sapiens, Rattus norvegicus
Mukai, J.; Asai, T.; Naka, M.; Tanaka, T.
Separation and characterization of a novel isoenzyme of cyclic nucleotide phosphodiesterase from rat cerebrum
Br. J. Pharmacol.
111
389-390
1994
Rattus norvegicus
Fujishige, K.; Kotera, J.; Omori, K.
Striatum- and testis-specific phosphodiesterase PDE10A. Isolation and characterization of a rat PDE10A
Eur. J. Biochem.
266
1118-1127
1999
Rattus norvegicus
Murata, T.; Sugatani, T.; Tagawa, T.
Expression of phosphodiesterase 3 in rat submandibular gland
Arch. Oral Biol.
45
1043-1047
2000
Rattus norvegicus
Murata, T.; Sugatani, T.; Manganiello, V.C.; Shimizu, K.; Tagawa, T.
Expression of phosphodiesterase 3 in rat submandibular gland cell lines
Arch. Oral Biol.
46
453-457
2001
Rattus norvegicus
Tanaka, S.; Shimooka, S.; Shimomura, H.
Changes in phosphodiesterase activity in the developing rat submandibular gland
Arch. Oral Biol.
47
567-576
2002
Rattus norvegicus
Yuasa, K.; Ohgaru, T.; Asahina, M.; Omori, K.
Identification of rat cyclic nucleotide phosphodiesterase 11A (PDE11A). Comparison of rat and human PDE11A splicing variants
Eur. J. Biochem.
268
4440-4448
2001
Rattus norvegicus
Nilsson, R.; Ahmad, F.; Sward, K.; Andersson, U.; Weston, M.; Manganiello, V.; Degerman, E.
Plasma membrane cyclic nucleotide phosphodiesterase 3B (PDE3B) is associated with caveolae in primary adipocytes
Cell. Signal.
18
1713-1721
2006
Rattus norvegicus
Keravis, T.; Thaseldar-Roumie, R.; Lugnier, C.
Assessment of phosphodiesterase isozyme contribution in cell and tissue extracts
Methods Mol. Biol.
307
63-74
2005
Rattus norvegicus
Yan, C.
Determination of Ca2+/calmodulin-stimulated phosphodiesterase activity in intact cells
Methods Mol. Biol.
307
85-92
2005
Rattus norvegicus
Witwicka, H.; Kobialka, M.; Siednienko, J.; Mitkiewicz, M.; Gorczyca, W.A.
Expression and activity of cGMP-dependent phosphodiesterases is up-regulated by lipopolysaccharide (LPS) in rat peritoneal macrophages
Biochim. Biophys. Acta
1773
209-218
2007
Rattus norvegicus
Nagel, D.J.; Aizawa, T.; Jeon, K.I.; Liu, W.; Mohan, A.; Wei, H.; Miano, J.M.; Florio, V.A.; Gao, P.; Korshunov, V.A.; Berk, B.C.; Yan, C.
Role of nuclear Ca2+/calmodulin-stimulated phosphodiesterase 1A in vascular smooth muscle cell growth and survival
Circ. Res.
98
777-784
2006
Rattus norvegicus
Rutten, K.; Prickaerts, J.; Hendrix, M.; van der Staay, F.J.; Sik, A.; Blokland, A.
Time-dependent involvement of cAMP and cGMP in consolidation of object memory: studies using selective phosphodiesterase type 2, 4 and 5 inhibitors
Eur. J. Pharmacol.
558
107-112
2007
Rattus norvegicus
de Vente, J.; Markerink-van Ittersum, M.; Vles, J.S.
The role of phosphodiesterase isoforms 2, 5, and 9 in the regulation of NO-dependent and NO-independent cGMP production in the rat cervical spinal cord
J. Chem. Neuroanat.
31
275-303
2006
Rattus norvegicus (Q01062)
Santone, R.; Giorgi, M.; Maccarone, R.; Basso, M.; Deplano, S.; Bisti, S.
Gene expression and protein localization of calmodulin-dependent phosphodiesterase in adult rat retina
J. Neurosci. Res.
84
1020-1026
2006
Rattus norvegicus
Siuciak, J.A.
The role of phosphodiesterases in schizophrenia: therapeutic implications
CNS Drugs
22
983-993
2008
Homo sapiens, Rattus norvegicus
van Donkelaar, E.L.; Rutten, K.; Blokland, A.; Akkerman, S.; Steinbusch, H.W.; Prickaerts, J.
Phosphodiesterase 2 and 5 inhibition attenuates the object memory deficit induced by acute tryptophan depletion
Eur. J. Pharmacol.
600
98-104
2008
Rattus norvegicus
Schmidt, C.J.; Chapin, D.S.; Cianfrogna, J.; Corman, M.L.; Hajos, M.; Harms, J.F.; Hoffman, W.E.; Lebel, L.A.; McCarthy, S.A.; Nelson, F.R.; Proulx-LaFrance, C.; Majchrzak, M.J.; Ramirez, A.D.; Schmidt, K.; Seymour, P.A.; Siuciak, J.A.; Tingley, F.D.; Williams, R.D.; Verhoest, P.R.; Menniti, F.S.
Preclinical characterization of selective phosphodiesterase 10A inhibitors: a new therapeutic approach to the treatment of schizophrenia
J. Pharmacol. Exp. Ther.
325
681-690
2008
Rattus norvegicus
Threlfell, S.; Sammut, S.; Menniti, F.S.; Schmidt, C.J.; West, A.R.
Inhibition of phosphodiesterase 10A increases the responsiveness of striatal projection neurons to cortical stimulation
J. Pharmacol. Exp. Ther.
328
785-795
2009
Rattus norvegicus
Dlaboga, D.; Hajjhussein, H.; ODonnell, J.M.
Chronic haloperidol and clozapine produce different patterns of effects on phosphodiesterase-1B, -4B, and -10A expression in rat striatum
Neuropharmacology
54
745-754
2008
Rattus norvegicus
Giachini, F.R.; Lima, V.V.; Carneiro, F.S.; Tostes, R.C.; Webb, R.C.
Decreased cGMP level contributes to increased contraction in arteries from hypertensive rats: role of phosphodiesterase 1
Hypertension
57
655-663
2011
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
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