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Aberrant Crypt Foci
Ursolic acid inhibits the formation of aberrant crypt foci and affects colonic sphingomyelin hydrolyzing enzymes in azoxymethane-treated rats.
Abortion, Spontaneous
Niemann-Pick disease: prenatal diagnoses and studies of sphingomyelinase activities.
Abscess
Clostridium septicum myonecrosis presenting as a parapharyngeal abscess in a patient with aplastic anemia.
Abscess
Effect immunization with highly purified alpha- and beta-toxins on staphylococcal mastitis in rabbits.
Acne Vulgaris
Propionibacterium acnes CAMP factor and host acid sphingomyelinase contribute to bacterial virulence: potential targets for inflammatory acne treatment.
Acute Coronary Syndrome
Elevation of ceramide and activation of secretory acid sphingomyelinase in patients with acute coronary syndromes.
Acute Generalized Exanthematous Pustulosis
Acute generalized exanthematous pustulosis and Coombs-positive hemolytic anemia in a child following Loxosceles reclusa envenomation.
Acute Kidney Injury
Altered sphingomyelinase and ceramide expression in the setting of ischemic and nephrotoxic acute renal failure.
Acute Lung Injury
A novel visible range FRET probe for monitoring acid sphingomyelinase activity in living cells.
Acute Lung Injury
Acid sphingomyelinase mediates murine acute lung injury following transfusion of aged platelets.
Acute Lung Injury
IKK NBD peptide inhibits LPS induced pulmonary inflammation and alters sphingolipid metabolism in a murine model.
Acute Lung Injury
PAF-mediated pulmonary edema: a new role for acid sphingomyelinase and ceramide.
Acute Lung Injury
Platelet-activating factor reduces endothelial NO production - role of acid sphingomyelinase.
Adenocarcinoma
'Patchiness' and basic cancer research: unravelling the proteases.
Adenocarcinoma
Detection of alkaline sphingomyelinase activity in human stool: proposed role as a new diagnostic and prognostic marker of colorectal cancer.
Adenocarcinoma
Familial adenomatous polyposis is associated with a marked decrease in alkaline sphingomyelinase activity: a key factor to the unrestrained cell proliferation?
Adenocarcinoma
Reciprocal relationship between cytosolic NADH and ENOX2 inhibition triggers sphingolipid-induced apoptosis in HeLa cells.
Adenocarcinoma
[Synchronous Multiple Primary Lung Cancer Dignosed ?by Different Phenotype-genotype: A Case Report and Literature Review].
Adenocarcinoma of Lung
Synchronous Bilateral Lung Cancer With Discordant Histology.
Adenoma
Chronic colitis is associated with a reduction of mucosal alkaline sphingomyelinase activity.
Adenoma
Effects of ursodeoxycholate and other bile salts on levels of rat intestinal alkaline sphingomyelinase: a potential implication in tumorigenesis.
Adenoma
Familial adenomatous polyposis is associated with a marked decrease in alkaline sphingomyelinase activity: a key factor to the unrestrained cell proliferation?
Adenoma
Reduction in alkaline sphingomyelinase in colorectal tumorigenesis is not related to the APC gene mutation.
Adenomatous Polyposis Coli
Familial adenomatous polyposis is associated with a marked decrease in alkaline sphingomyelinase activity: a key factor to the unrestrained cell proliferation?
Adenomatous Polyposis Coli
Reduction in alkaline sphingomyelinase in colorectal tumorigenesis is not related to the APC gene mutation.
Aggressive Periodontitis
Sphingomyelin Phosphodiesterase 3 Enhances Cytodifferentiation of Periodontal Ligament Cells.
Alveolar Bone Loss
Acid sphingomyelinase deficiency exacerbates LPS-induced experimental periodontitis.
Alzheimer Disease
Acid sphingomyelinase modulates the autophagic process by controlling lysosomal biogenesis in Alzheimer's disease.
Alzheimer Disease
Cambinol, a novel inhibitor of neutral sphingomyelinase 2 shows neuroprotective properties.
Alzheimer Disease
Fibrillar amyloid-beta peptides kill human primary neurons via NADPH oxidase-mediated activation of neutral sphingomyelinase. Implications for Alzheimer's disease.
Alzheimer Disease
Fibrillar amyloid-beta-activated human astroglia kill primary human neurons via neutral sphingomyelinase: implications for Alzheimer's disease.
Alzheimer Disease
Interactions between neural membrane glycerophospholipid and sphingolipid mediators: a recipe for neural cell survival or suicide.
Alzheimer Disease
Neutral Sphingomyelinase-2 Deficiency Ameliorates Alzheimer's Disease Pathology and Improves Cognition in the 5XFAD Mouse.
Alzheimer Disease
Novel Human Neutral Sphingomyelinase 2 Inhibitors as Potential Therapeutics for Alzheimer's Disease.
Alzheimer Disease
Role of sphingomyelinases in neurological disorders.
Alzheimer Disease
Roles and regulation of neutral sphingomyelinase-2 in cellular and pathological processes.
Alzheimer Disease
The Roles of Neutral Sphingomyelinases in Neurological Pathologies.
Alzheimer Disease
Tunable regulatory activities of 1,10-phenanthroline derivatives towards acid sphingomyelinase and Zn(ii)-amyloid-?.
Alzheimer Disease
[Advance in research on regulatory mechanism and functions of neutral sphingomyelinse 2].
Anaphylaxis
Mechanistic characterization and inhibition of sphingomyelinase C over substituted Iron Schiff bases of chitosan adsorbed on glassy carbon electrode.
Anaplasmosis
Functional inhibition or genetic deletion of acid sphingomyelinase bacteriostatically inhibits Anaplasma phagocytophilum infection in vivo.
Anemia
Acute Gaucher Disease-Like Condition in an Indian Infant with a Novel Biallelic Mutation in the Prosaposin Gene.
Anemia
Functional consequences of sphingomyelinase-induced changes in erythrocyte membrane structure.
Anemia
Liver cell death and anemia in Wilson disease involve acid sphingomyelinase and ceramide.
Anemia
Susceptibility to staphylococcal alpha-toxin of Friend virus-infected murine erythroblasts during differentiation.
Anemia, Hemolytic
Clostridium Perfringens Bacteremia with Acute Hemolytic Anemia in the Setting of Endometrial Malignancy.
Anemia, Sickle Cell
Acid sphingomyelinase is activated in sickle cell erythrocytes and contributes to inflammatory microparticle generation in SCD.
Angiokeratoma
A novel association between angiokeratoma corporis diffusum and acid sphingomyelinase deficiency.
Anthrax
Membrane insertion: The strategies of toxins (review).
Arthritis
Regulation of Arthritis Severity by the Acid Sphingomyelinase.
Arthritis
Severity of group B streptococcal arthritis is correlated with beta-hemolysin expression.
Arthritis, Infectious
Alpha-toxin and gamma-toxin jointly promote Staphylococcus aureus virulence in murine septic arthritis.
Arthritis, Rheumatoid
Acid sphingomyelinase activity is elevated in the serum of rheumatoid arthritis patients, suppressed by anti-TNF-? treatment.
Arthritis, Rheumatoid
Acid Sphingomyelinase and Acid ?-Glucosidase 1 Exert Opposite Effects on Interleukin-1?-Induced Interleukin 6 Production in Rheumatoid Arthritis Fibroblast-Like Synoviocytes.
Arthritis, Rheumatoid
Regulation of Arthritis Severity by the Acid Sphingomyelinase.
Arthritis, Rheumatoid
Secretory sphingomyelinase (S-SMase) activity is elevated in patients with rheumatoid arthritis.
Arthrogryposis
Loss of SMPD4 Causes a Developmental Disorder Characterized by Microcephaly and Congenital Arthrogryposis.
Arthus Reaction
Different pathways leading to cutaneous leukocytoclastic vasculitis in mice.
Asthma
Acid sphingomyelinase regulates TH 2-cytokine release and bronchial asthma.
Asthma
Ceramide induction of COX-2 and PGE(2) in pulmonary A549 cells does not involve activation of NF-kappaB.
Asthma
Immunoregulatory role of acid sphingomyelinase in allergic asthma.
Asthma
Sphingomyelin metabolism in erythrocyte membrane in asthma.
Astrocytoma
Cytokine and intracellular signaling regulation of tissue factor expression in astrocytes.
Astrocytoma
Stimulation of the sphingomyelin pathway induces interleukin-6 gene expression in human astrocytoma cells.
Ataxia
Disruption of myelin sheaths in mouse brain in vitro and in vivo by staphylococcal alpha-toxin.
Ataxia
Highly variable neural involvement in sphingomyelinase-deficient Niemann-Pick disease caused by an ancestral Gypsy mutation.
Atherosclerosis
A high-throughput sphingomyelinase assay using natural substrate.
Atherosclerosis
A novel high-throughput screening format to identify inhibitors of secreted acid sphingomyelinase.
Atherosclerosis
A Robust Liposomal Platform for Direct Colorimetric Detection of Sphingomyelinase Enzyme and Inhibitors.
Atherosclerosis
Acid sphingomyelinase promotes lipoprotein retention within early atheromata and accelerates lesion progression.
Atherosclerosis
Acid sphingomyelinase, autophagy, and atherosclerosis.
Atherosclerosis
Acute systemic inflammation up-regulates secretory sphingomyelinase in vivo: a possible link between inflammatory cytokines and atherogenesis.
Atherosclerosis
Alkaline sphingomyelinase: an old enzyme with novel implications.
Atherosclerosis
Amitriptyline inhibits nonalcoholic steatohepatitis and atherosclerosis induced by high-fat diet and LPS through modulation of sphingolipid metabolism.
Atherosclerosis
Boswellic acid inhibits expression of acid sphingomyelinase in intestinal cells.
Atherosclerosis
Ceramide in lipid particles enhances heparan sulfate proteoglycan and low density lipoprotein receptor-related protein-mediated uptake by macrophages.
Atherosclerosis
Contribution of acid sphingomyelinase to angiotensin II-induced vascular adventitial remodeling via membrane rafts/Nox2 signal pathway.
Atherosclerosis
Control of autophagy maturation by acid sphingomyelinase in mouse coronary arterial smooth muscle cells: protective role in atherosclerosis.
Atherosclerosis
Dual effect of ceramide on human endothelial cells: induction of oxidative stress and transcriptional upregulation of endothelial nitric oxide synthase.
Atherosclerosis
Effect of dietary cholesterol and high fat on ceramide concentration in rat tissues.
Atherosclerosis
Elevation of ceramide and activation of secretory acid sphingomyelinase in patients with acute coronary syndromes.
Atherosclerosis
Facile Method for Specifically Sensing Sphingomyelinase in Cells and Human Urine Based on a Ratiometric Fluorescent Nanoliposome Probe.
Atherosclerosis
Human vascular endothelial cells are a rich and regulatable source of secretory sphingomyelinase. Implications for early atherogenesis and ceramide-mediated cell signaling.
Atherosclerosis
Interactions between sphingomyelin and cholesterol in low density lipoproteins and model membranes.
Atherosclerosis
Modification of LDL with human secretory phospholipase A(2) or sphingomyelinase promotes its arachidonic acid-releasing propensity.
Atherosclerosis
Modulation of sphingomyelinase-induced cholesterol esterification in fibroblasts, CaCo2 cells, macrophages and smooth muscle cells.
Atherosclerosis
Neutral sphingomyelinase: past, present and future.
Atherosclerosis
Neutral/alkaline and acid ceramidase activities are actively released by murine endothelial cells.
Atherosclerosis
nSMase2 (Type 2-Neutral Sphingomyelinase) Deficiency or Inhibition by GW4869 Reduces Inflammation and Atherosclerosis in Apoe-/- Mice.
Atherosclerosis
Oxidized phospholipids in minimally modified low density lipoprotein induce apoptotic signaling via activation of acid sphingomyelinase in arterial smooth muscle cells.
Atherosclerosis
Platelet arachidonic acid metabolism in severe cerebrovascular disease.
Atherosclerosis
Rabbit aorta and human atherosclerotic lesions hydrolyze the sphingomyelin of retained low-density lipoprotein. Proposed role for arterial-wall sphingomyelinase in subendothelial retention and aggregation of atherogenic lipoproteins.
Atherosclerosis
Secretory sphingomyelinase, a product of the acid sphingomyelinase gene, can hydrolyze atherogenic lipoproteins at neutral pH. Implications for atherosclerotic lesion development.
Atherosclerosis
Secretory sphingomyelinase.
Atherosclerosis
Short-term magnesium deficiency downregulates telomerase, upregulates neutral sphingomyelinase and induces oxidative DNA damage in cardiovascular tissues: relevance to atherogenesis, cardiovascular diseases and aging.
Atherosclerosis
Sphingolipids in atherosclerosis and vascular biology.
Atherosclerosis
Sphingomyelin phosphodiesterase acid-like 3A (SMPDL3A) is a novel nucleotide phosphodiesterase regulated by cholesterol in human macrophages.
Atherosclerosis
Sphingomyelinase activity of LDL: a link between atherosclerosis, ceramide, and apoptosis?
Atherosclerosis
Sphingomyelinase converts lipoproteins from apolipoprotein E knockout mice into potent inducers of macrophage foam cell formation.
Atherosclerosis
Sphingomyelinase induces aggregation and fusion of small very low-density lipoprotein and intermediate-density lipoprotein particles and increases their retention to human arterial proteoglycans.
Atherosclerosis
Sphingomyelinase, an enzyme implicated in atherogenesis, is present in atherosclerotic lesions and binds to specific components of the subendothelial extracellular matrix.
Atherosclerosis
Sphingomyelinases: their regulation and roles in cardiovascular pathophysiology.
Atherosclerosis
Strong Inhibition of Secretory Sphingomyelinase by Catechins, Particularly by (-)-Epicatechin 3-O-Gallate and (-)-3'-O-Methylepigallocatechin 3-O-Gallate.
Atherosclerosis
Suppressing the intestinal farnesoid X receptor/sphingomyelin phosphodiesterase 3 axis decreases atherosclerosis.
Atherosclerosis
The cellular trafficking and zinc dependence of secretory and lysosomal sphingomyelinase, two products of the acid sphingomyelinase gene.
Atherosclerosis
The Polycomb group protein EED couples TNF receptor 1 to neutral sphingomyelinase.
Atherosclerosis
The Roles of Neutral Sphingomyelinases in Neurological Pathologies.
Autoimmune Diseases
Molecular modeling of human neutral sphingomyelinase provides insight into its molecular interactions.
Bacteremia
Characterization of alpha-toxin hla gene variants, alpha-toxin expression levels, and levels of antibody to alpha-toxin in hemodialysis and postsurgical patients with Staphylococcus aureus bacteremia.
Bacteremia
Distinguishing complicated from uncomplicated bacteremia caused by Staphylococcus aureus: the value of "new" and "old" serological tests.
Bacteremia
Evaluation of seven different enzyme-linked immunosorbent assays for serodiagnosis of Staphylococcus aureus bacteremia.
Bacteremia
Hemolysin and K antigens in relation to serotype and hemagglutination type of Escherichia coli isolated from extraintestinal infections.
Bacteremia
Isogenic group B streptococci devoid of capsular polysaccharide or beta-hemolysin: pulmonary hemodynamic and gas exchange effects during bacteremia in piglets.
Bacteremia
Multimechanistic Monoclonal Antibodies (MAbs) Targeting Staphylococcus aureus Alpha-Toxin and Clumping Factor A: Activity and Efficacy Comparisons of a MAb Combination and an Engineered Bispecific Antibody Approach.
Bacteremia
Serology of Staphylococcus aureus infections using multiple antigens and serial serum samples.
Bacterial Infections
Defective Acid Sphingomyelinase Pathway with Pseudomonas aeruginosa Infection in Cystic Fibrosis.
Bacterial Infections
Extravasation of staphylococcal alpha-toxin in normal and injured CNS regions lacking blood-brain barrier function: observations after ventral root replantation.
Bacterial Infections
Neutral sphingomyelinase 2 is a key factor for PorB-dependent invasion of Neisseria gonorrhoeae.
Bacterial Infections
The role of acid sphingomyelinase and modulation of sphingolipid metabolism in bacterial infection.
Beckwith-Wiedemann Syndrome
Acid sphingomyelinase deficiency in Beckwith Wiedemann syndrome.
Bone Resorption
Sphingomyelinase and ceramide inhibit formation of F-actin ring in and bone resorption by rabbit mature osteoclasts.
Botulism
Investigation of Clostridium botulinum group III's mobilome content.
Brain Abscess
Diminished virulence of an alpha-toxin mutant of Staphylococcus aureus in experimental brain abscesses.
Brain Concussion
The Role of Acid Sphingomyelinase Inhibition in Repetitive Mild Traumatic Brain Injury.
Brain Injuries
Acid sphingomyelinase deficiency protects mitochondria and improves function recovery after brain injury.
Brain Injuries
Inhibition of extracellular vesicle pathway using neutral sphingomyelinase inhibitors as a neuroprotective treatment for brain injury.
Brain Injuries
Sphingomyelinase and ceramide analogs induce vasoconstriction and leukocyte-endothelial interactions in cerebral venules in the intact rat brain: Insight into mechanisms and possible relation to brain injury and stroke.
Brain Injuries, Traumatic
Acid Sphingomyelinase Inhibition Mitigates Histopathologic and Behavioral Changes in a Murine Model of Traumatic Brain Injury.
Brain Injuries, Traumatic
Neutral Sphingomyelinase Inhibition Alleviates LPS-Induced Microglia Activation and Neuroinflammation after Experimental Traumatic Brain Injury.
Brain Ischemia
Homozygous Smpd1 deficiency aggravates brain ischemia/ reperfusion injury by mechanisms involving polymorphonuclear neutrophils, whereas heterozygous Smpd1 deficiency protects against mild focal cerebral ischemia.
Brain Ischemia
Pivotal role for acidic sphingomyelinase in cerebral ischemia-induced ceramide and cytokine production, and neuronal apoptosis.
Brain Ischemia
Role of sphingomyelinases in neurological disorders.
Brain Ischemia
The Acid Sphingomyelinase/ Ceramide System as Target for Ischemic Stroke Therapies.
Brain Ischemia
Tumor necrosis factor alpha increases neuronal vulnerability to excitotoxic necrosis by inducing expression of the AMPA-glutamate receptor subunit GluR1 via an acid sphingomyelinase- and NF-kappaB-dependent mechanism.
Brain Ischemia
Upregulation of ceramide and its regulating mechanism in a rat model of chronic cerebral ischemia.
Brain Ischemia
[Synthesis of sphingomyelin analogues as a sphingomyelinase inhibitor and the application as a blocking agent of extracellular stress signaling]
Brain Neoplasms
Sphingolipid Metabolism in Glioblastoma and Metastatic Brain Tumors: A Review of Sphingomyelinases and Sphingosine-1-Phosphate.
Breast Neoplasms
'Patchiness' and basic cancer research: unravelling the proteases.
Breast Neoplasms
A novel role for protein kinase Cdelta-mediated phosphorylation of acid sphingomyelinase in UV light-induced mitochondrial injury.
Breast Neoplasms
alpha-TEA-induced death receptor dependent apoptosis involves activation of acid sphingomyelinase and elevated ceramide enriched cell surface membranes.
Breast Neoplasms
Association between CLN3 (Neuronal Ceroid Lipofuscinosis, CLN3 Type) Gene Expression and Clinical Characteristics of Breast Cancer Patients.
Breast Neoplasms
Comparative epigenomics of human and mouse mammary tumors.
Breast Neoplasms
Disruption of retinoic acid receptor alpha reveals the growth promoter face of retinoic acid.
Breast Neoplasms
Glutathione regulation of neutral sphingomyelinase in tumor necrosis factor-alpha-induced cell death.
Breast Neoplasms
Molecular characterization of human breast tumor vascular cells.
Breast Neoplasms
Neutral Sphingomyelinase 2 Heightens Anti-Melanoma Immune Responses and Anti-PD-1 Therapy Efficacy.
Breast Neoplasms
Neutral sphingomyelinase and breast cancer research.
Breast Neoplasms
Novel quinuclidinone derivative 8a induced apoptosis in human MCF-7 breast cancer cell lines.
Breast Neoplasms
Quinuclidinone derivative 6 induced apoptosis in human breast cancer cells via sphingomyelinase and JNK signaling.
Breast Neoplasms
Regulated secretion of acid sphingomyelinase: implications for selectivity of ceramide formation.
Breast Neoplasms
Role for mammalian neutral sphingomyelinase 2 in confluence-induced growth arrest of MCF7 cells.
Breast Neoplasms
Selective hydrolysis of a mitochondrial pool of sphingomyelin induces apoptosis.
Breast Neoplasms
Transcriptional regulation of neutral sphingomyelinase 2 gene expression of a human breast cancer cell line, MCF-7, induced by the anti-cancer drug, daunorubicin.
Breast Neoplasms
Transcriptional regulation of neutral sphingomyelinase 2 in all-trans retinoic acid-treated human breast cancer cell line, MCF-7.
Bronchiolitis
Elevation of Serum Acid Sphingomyelinase Activity in Children with Acute Respiratory Syncytial Virus Bronchiolitis.
Carcinogenesis
Alkaline sphingomyelinase (NPP7) in hepatobiliary diseases: A field that needs to be closely studied.
Carcinogenesis
Cloning of alkaline sphingomyelinase from rat intestinal mucosa and adjusting of the hypothetical protein XP_221184 in GenBank.
Carcinogenesis
Dietary sphingomyelin inhibits colonic tumorigenesis with an up-regulation of alkaline sphingomyelinase expression in ICR mice.
Carcinogenesis
Effects of phospholipids on sphingomyelin hydrolysis induced by intestinal alkaline sphingomyelinase: an in vitro study.
Carcinogenesis
Effects of ursodeoxycholate and other bile salts on levels of rat intestinal alkaline sphingomyelinase: a potential implication in tumorigenesis.
Carcinogenesis
Enhanced colonic tumorigenesis in alkaline sphingomyelinase (NPP7) knockout mice.
Carcinogenesis
Identification of aberrant forms of alkaline sphingomyelinase (NPP7) associated with human liver tumorigenesis.
Carcinogenesis
Mutations in the neutral sphingomyelinase gene SMPD3 implicate the ceramide pathway in human leukemias.
Carcinogenesis
Neutral sphingomyelinase-3 is a DNA damage and nongenotoxic stress-regulated gene that is deregulated in human malignancies.
Carcinogenesis
Next Generation Sequencing Reveals a Synchronous Trilateral Lung Adenocarcinoma Case with Distinct Driver Alterations of EGFR 19 Deletion or EGFR 20 Insertion or EZR-ROS1 Fusion.
Carcinogenesis
Pancreatic and mucosal enzymes in choline phospholipid digestion.
Carcinogenesis
Purification, characterization, and expression of rat intestinal alkaline sphingomyelinase.
Carcinogenesis
Reduction in alkaline sphingomyelinase in colorectal tumorigenesis is not related to the APC gene mutation.
Carcinogenesis
Understanding the molecular activity of alkaline sphingomyelinase (NPP7) by computer modeling.
Carcinoma
Abnormal methylation status of FBXW10 and SMPD3, and associations with clinical characteristics in clear cell renal cell carcinoma.
Carcinoma
Acid sphingomyelinase activity as an indicator of the cell stress in HPV-positive and HPV-negative head and neck squamous cell carcinoma.
Carcinoma
Acidic sphingomyelinase induced by electrophiles promotes proinflammatory cytokine production in human bladder carcinoma ECV-304 cells.
Carcinoma
Alkaline sphingomyelinase activity is decreased in human colorectal carcinoma.
Carcinoma
c-Abl Is an Upstream Regulator of Acid Sphingomyelinase in Apoptosis Induced by Inhibition of Integrins ?v?3 and ?v?5.
Carcinoma
Different apoptosis ratios and gene expressions in two human cell lines after sevoflurane anaesthesia.
Carcinoma
Effects of ursodeoxycholate and other bile salts on levels of rat intestinal alkaline sphingomyelinase: a potential implication in tumorigenesis.
Carcinoma
Enhanced acid sphingomyelinase activity drives immune evasion and tumor growth in non-small cell lung carcinoma.
Carcinoma
Glutathione regulation of neutral sphingomyelinase in tumor necrosis factor-alpha-induced cell death.
Carcinoma
Increased liver tumor formation in neutral sphingomyelinase-2 deficient mice.
Carcinoma
Lack of ceramide generation and altered sphingolipid composition are associated with drug resistance in human ovarian carcinoma cells.
Carcinoma
Nrf2 up-regulates the induction of acidic sphingomyelinase by electrophiles.
Carcinoma
Purified intestinal alkaline sphingomyelinase inhibits proliferation without inducing apoptosis in HT-29 colon carcinoma cells.
Carcinoma
Sphingomyelin phosphodiesterase 3 methylation and silencing in oral squamous cell carcinoma results in increased migration and invasion and altered stress response.
Carcinoma
Studies of the Biologic Activity of Purified Staphylococcal Alpha-Toxin: II. The Effect of Alpha-Toxin on Ehrlich Ascites Carcinoma Cells.
Carcinoma
Synchronous Bilateral Lung Cancer With Discordant Histology.
Carcinoma
TSAP6 is a novel candidate marker of poor survival in metastatic high-grade serous carcinoma.
Carcinoma
[Synchronous Multiple Primary Lung Cancer Dignosed ?by Different Phenotype-genotype: A Case Report and Literature Review].
Carcinoma, Hepatocellular
A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation.
Carcinoma, Hepatocellular
Celecoxib-mediated activation of endoplasmic reticulum stress induces de novo ceramide biosynthesis and apoptosis in hepatoma HepG2 cells mobilization.
Carcinoma, Hepatocellular
Common inhibitory serine sites phosphorylated by IRS-1 kinases, triggered by insulin and inducers of insulin resistance.
Carcinoma, Hepatocellular
Existence of Mg2+-dependent, neutral sphingomyelinase in nuclei of rat ascites hepatoma cells.
Carcinoma, Hepatocellular
Exosomal neutral sphingomyelinase 1 suppresses hepatocellular carcinoma via decreasing the ratio of sphingomyelin/ceramide.
Carcinoma, Hepatocellular
Human alkaline ceramidase 2 promotes the growth, invasion, and migration of hepatocellular carcinoma cells via sphingomyelin phosphodiesterase acid-like 3B.
Carcinoma, Hepatocellular
Nuclear localization of neutral sphingomyelinase 1: biochemical and immunocytochemical analyses.
Carcinoma, Hepatocellular
Plasma membrane sphingomyelin and the regulation of HMG-CoA reductase activity and cholesterol biosynthesis in cell cultures.
Carcinoma, Hepatocellular
Regulation of UDP-glucose:ceramide glucosyltransferase-1 by ceramide.
Carcinoma, Hepatocellular
Sphingomyelinase and ceramide suppress insulin-induced tyrosine phosphorylation of the insulin receptor substrate-1.
Carcinoma, Hepatocellular
Sphingomyelinases and Liver Diseases.
Carcinoma, Non-Small-Cell Lung
Abnormal methylation of seven genes and their associations with clinical characteristics in early stage non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Ceramide mediates nanovesicle shedding and cell death in response to phosphatidylinositol ether lipid analogs and perifosine.
Carcinoma, Non-Small-Cell Lung
Enhanced acid sphingomyelinase activity drives immune evasion and tumor growth in non-small cell lung carcinoma.
Carcinoma, Renal Cell
Abnormal methylation status of FBXW10 and SMPD3, and associations with clinical characteristics in clear cell renal cell carcinoma.
Carcinoma, Renal Cell
Data on cell survival, apoptosis, ceramide metabolism and oxidative stress in A-494 renal cell carcinoma cell line treated with hesperetin and hesperetin-7-O-acetate.
Carcinoma, Squamous Cell
Acid sphingomyelinase activity as an indicator of the cell stress in HPV-positive and HPV-negative head and neck squamous cell carcinoma.
Carcinoma, Squamous Cell
Radioresistance of human carcinoma cells is correlated to a defect in raft membrane clustering.
Cardiomyopathies
Adjustment of Dysregulated Ceramide Metabolism in a Murine Model of Sepsis-Induced Cardiac Dysfunction.
Cardiomyopathies
HILIC-MS-based metabolomics reveal that Astragalus polysaccharide alleviates doxorubicin-induced cardiomyopathy by regulating sphingolipid and glycerophospholipid homeostasis.
Cardiovascular Diseases
Acid sphingomyelinase downregulation alleviates vascular endothelial leptin resistance in rats.
Cardiovascular Diseases
Hemolytic and sphingomyelinase activities of Clostridium perfringens alpha-toxin are dependent on a domain homologous to that of an enzyme from the human arachidonic acid pathway.
Cardiovascular Diseases
Identification and biochemical characterization of an acid sphingomyelinase-like protein from the bacterial plant pathogen Ralstonia solanacearum that hydrolyzes ATP to AMP but not sphingomyelin to ceramide.
Cardiovascular Diseases
Short-term magnesium deficiency downregulates telomerase, upregulates neutral sphingomyelinase and induces oxidative DNA damage in cardiovascular tissues: relevance to atherogenesis, cardiovascular diseases and aging.
Cardiovascular Diseases
Sphingomyelinases: their regulation and roles in cardiovascular pathophysiology.
Cataplexy
Gelastic cataplexy in Niemann-Pick disease group C and related variants without generalized sphingomyelinase deficiency.
ceramidase deficiency
Acid Sphingomyelinase Deficiency Ameliorates Farber Disease.
Cerebral Infarction
Inhibition of sphingomyelinase activity helps to prevent neuron death caused by ischemic stress.
Chagas Disease
Trypanosoma cruzi modulates gene expression of plasma membrane repair-related proteins.
Chemical and Drug Induced Liver Injury
Activity of sphingomyelinase in rat liver in acute and chronic toxic hepatitis: proportion between peroxidative and phospholipase pathways of lipid bilayer modification.
Chemical and Drug Induced Liver Injury
Functional activity of sphingomyelin cycle in rat liver in chronic toxic hepatitis.
Chickenpox
Comparative study of immune status to infectious agents in elderly patients with multiple myeloma, Waldenstrom's macroglobulinemia, and monoclonal gammopathy of undetermined significance.
Chickenpox
Relationship between endotoxin core, staphylococcal and varicella antibody levels and outcome following aortic valve replacement surgery: a prospective observational study.
Cholera
A simple method for the determination of the pore radius of ion channels in planar lipid bilayer membranes.
Cholera
Cholera toxin B-subunit prevents activation and proliferation of human CD4+ T cells by activation of a neutral sphingomyelinase in lipid rafts.
Cholera
Different types of cell death induced by enterotoxins.
Cholera
Interleukin-1 beta stimulates sphingomyelin hydrolysis in cultured granulosa cells: evidence for a regulatory role of ceramide on progesterone and prostaglandin biosynthesis.
Cholera
Melanogenesis in murine B16 cells exposed to Aeromonas hydrophila cytotoxic enterotoxin.
Cholera
Microbial sphingomyelinase induces RhoA-mediated reorganization of the apical brush border membrane and is protective against invasion.
Cholera
The role of bacterial and non-bacterial toxins in the induction of changes in membrane transport: implications for diarrhea.
Cholera
[Antibacterial and anti-hemolysin activities of tea catechins and their structural relatives]
Cholera
[Relationship between the anti-hemolysin activity and the structure of catechins and theaflavins]
Cholestasis
[Relationship of tumor necrosis factor alpha expression with activation of sphingomyelinase and lipid peroxidation after removal of cholestatic factor]
Cholestasis, Intrahepatic
Lithocholic acid disrupts phospholipid and sphingolipid homeostasis leading to cholestasis in mice.
Clostridium Infections
Role of alpha-toxin in Clostridium perfringens infection determined by using recombinants of C. perfringens and Bacillus subtilis.
Coinfection
Candida albicans Augments Staphylococcus aureus Virulence by Engaging the Staphylococcal agr Quorum Sensing System.
Coinfection
Linezolid Attenuates Lethal Lung Damage during Postinfluenza Methicillin-Resistant Staphylococcus aureus Pneumonia.
Colitis
Acid sphingomyelinase inhibition suppresses lipopolysaccharide-mediated release of inflammatory cytokines from macrophages and protects against disease pathology in dextran sulphate sodium-induced colitis in mice.
Colitis
Chronic colitis is associated with a reduction of mucosal alkaline sphingomyelinase activity.
Colitis
Deficiency of alkaline SMase enhances dextran sulfate sodium-induced colitis in mice with upregulation of autotaxin.
Colitis
Expression of Alkaline Sphingomyelinase in Yeast Cells and Anti-inflammatory Effects of the Expressed Enzyme in a Rat Colitis Model.
Colitis
Inhibition of lipopolysaccharide-induced release of interleukin-8 from intestinal epithelial cells by SMA, a novel inhibitor of sphingomyelinase and its therapeutic effect on dextran sulphate sodium-induced colitis in mice.
Colitis
Intestinal Acid Sphingomyelinase Protects From Severe Pathogen-Driven Colitis.
Colitis
VSL#3 probiotic upregulates intestinal mucosal alkaline sphingomyelinase and reduces inflammation.
Colitis, Ulcerative
VSL#3 probiotic upregulates intestinal mucosal alkaline sphingomyelinase and reduces inflammation.
Colitis-Associated Neoplasms
Deficiency of alkaline SMase enhances dextran sulfate sodium-induced colitis in mice with upregulation of autotaxin.
Colonic Neoplasms
Alkaline sphingomyelinase: an old enzyme with novel implications.
Colonic Neoplasms
Cisplatin-induced CD95 redistribution into membrane lipid rafts of HT29 human colon cancer cells.
Colonic Neoplasms
Curcumin decreases acid sphingomyelinase activity in colon cancer Caco-2 cells.
Colonic Neoplasms
Dietary sphingomyelin inhibits colonic tumorigenesis with an up-regulation of alkaline sphingomyelinase expression in ICR mice.
Colonic Neoplasms
Identification of one exon deletion of intestinal alkaline sphingomyelinase in colon cancer HT-29 cells and a differentiation-related expression of the wild-type enzyme in Caco-2 cells.
Colonic Neoplasms
Inhibitory Effect of Lactobacillus plantarum Extracts on HT-29 Colon Cancer Cell Apoptosis Induced by Staphylococcus aureus and Its Alpha-Toxin.
Colonic Neoplasms
Intestinal alkaline sphingomyelinase hydrolyses and inactivates platelet-activating factor by a phospholipase C activity.
Colonic Neoplasms
Liver acid sphingomyelinase inhibits growth of metastatic colon cancer.
Colonic Neoplasms
Purification, localization, and expression of human intestinal alkaline sphingomyelinase.
Colonic Neoplasms
Purified intestinal alkaline sphingomyelinase inhibits proliferation without inducing apoptosis in HT-29 colon carcinoma cells.
Colonic Neoplasms
Sphingosine Kinase Isoforms Regulate Oxaliplatin Sensitivity of Human Colon Cancer Cells through Ceramide Accumulation and Akt Activation.
Colonic Neoplasms
Ursodeoxycholic acid differentially affects three types of sphingomyelinase in human colon cancer Caco 2 cells.
Colonic Neoplasms
Ursodeoxycholic acid increases the activities of alkaline sphingomyelinase and caspase-3 in the rat colon.
Colonic Neoplasms
Ursolic Acid Inhibits Acid Sphingomyelinase in Intestinal Cells.
Colorectal Neoplasms
Alkaline sphingomyelinase activity is decreased in human colorectal carcinoma.
Colorectal Neoplasms
Chronic colitis is associated with a reduction of mucosal alkaline sphingomyelinase activity.
Colorectal Neoplasms
Comparative lipidomics of 5-Fluorouracil-sensitive and -resistant colorectal cancer cells reveals altered sphingomyelin and ceramide controlled by acid sphingomyelinase (SMPD1).
Colorectal Neoplasms
Detection of alkaline sphingomyelinase activity in human stool: proposed role as a new diagnostic and prognostic marker of colorectal cancer.
Colorectal Neoplasms
Reduction in alkaline sphingomyelinase in colorectal tumorigenesis is not related to the APC gene mutation.
Colorectal Neoplasms
The Effects of ASMase Mediated Endothelial Cell Apoptosis in Multiple Hypofractionated Irradiations in CT26 Tumor Bearing Mice.
Colorectal Neoplasms
[Effect of jianpi-jiedu formula on tumor angiogenesis-relevant genes expression in colorectal cancer].
Communicable Diseases
Inhibitory effects of various plant polyphenols on the toxicity of Staphylococcal alpha-toxin.
Communicable Diseases
Novel inhibitor of bacterial sphingomyelinase, SMY-540, developed based on three-dimensional structure analysis.
Communicable Diseases
Pore-forming activity of alpha-toxin is essential for clostridium septicum-mediated myonecrosis.
Communicable Diseases
Role of sphingomyelinase in infectious diseases caused by Bacillus cereus.
Communicable Diseases
Selective killing of human monocytes and cytokine release provoked by sphingomyelinase (beta-toxin) of Staphylococcus aureus.
Communicable Diseases
Stimulation of PAF-synthesis in pulmonary artery endothelial cells by Staphylococcus aureus alpha-toxin.
Congenital Abnormalities
Role of SMPD3 during Bone Fracture Healing and Regulation of Its Expression.
Congenital Abnormalities
Smpd3 Expression in both Chondrocytes and Osteoblasts Is Required for Normal Endochondral Bone Development.
Congenital Abnormalities
Sphingolipid metabolism and its role in the skeletal tissues.
Corneal Diseases
Effects of toxin production in a murine model of Staphylococcus aureus keratitis.
Corneal Edema
Histopathological studies of staphylococcal alpha-toxin: effects on rabbit corneas.
Corneal Injuries
Chemical Inhibition of Alpha-Toxin, a Key Corneal Virulence Factor of Staphylococcus aureus.
Corneal Injuries
Effectiveness of Alpha-toxin Fab Monoclonal Antibody Therapy in Limiting the Pathology of Staphylococcus aureus Keratitis.
Corneal Injuries
Host defense against bacterial keratitis.
Corneal Injuries
Immunization with alpha-toxin toxoid protects the cornea against tissue damage during experimental Staphylococcus aureus keratitis.
Coronary Disease
Sphingomyelinase activity of LDL: a link between atherosclerosis, ceramide, and apoptosis?
COVID-19
Association between Functional Inhibitors of Acid Sphingomyelinase (FIASMAs) and Reduced Risk of Death in COVID-19 Patients: A Retrospective Cohort Study.
COVID-19
Pharmacological Inhibition of Acid Sphingomyelinase Prevents Uptake of SARS-CoV-2 by Epithelial Cells.
COVID-19
Repurposing antidepressants inhibiting the sphingomyelinase acid/ceramide system against COVID-19: current evidence and potential mechanisms.
COVID-19
SARS-CoV-2 infection induces the activation of tissue factor-mediated coagulation via activation of acid sphingomyelinase.
COVID-19
Update on Functional Inhibitors of Acid Sphingomyelinase (FIASMAs) in SARS-CoV-2 Infection.
Crohn Disease
The Clostridium perfringensalpha-toxin.
Cryptosporidiosis
Involvement of Cryptosporidium parvum Cdg7_FLc_1000 RNA in the Attenuation of Intestinal Epithelial Cell Migration via Trans-Suppression of Host Cell SMPD3.
Cystic Fibrosis
Accumulation of ceramide in the trachea and intestine of cystic fibrosis mice causes inflammation and cell death.
Cystic Fibrosis
Acid Sphingomyelinase Inhibitors Normalize Pulmonary Ceramide and Inflammation in Cystic Fibrosis.
Cystic Fibrosis
Antibodies to staphylococcal teichoic acid and alpha toxin in patients with cystic fibrosis.
Cystic Fibrosis
Bacterial Sphingomyelinase is a State-Dependent Inhibitor of the Cystic Fibrosis Transmembrane conductance Regulator (CFTR).
Cystic Fibrosis
Ceramide in Pseudomonas aeruginosa infections and cystic fibrosis.
Cystic Fibrosis
Ceramide mediates lung fibrosis in cystic fibrosis.
Cystic Fibrosis
Defective Acid Sphingomyelinase Pathway with Pseudomonas aeruginosa Infection in Cystic Fibrosis.
Cystic Fibrosis
Expression of intestinal and lung alkaline sphingomyelinase and neutral ceramidase in cystic fibrosis f508del transgenic mice.
Cystic Fibrosis
Precision toxicology shows that troxerutin alleviates ochratoxin A-induced renal lipotoxicity.
Cystic Fibrosis
The role of sphingolipids and ceramide in pulmonary inflammation in cystic fibrosis.
Cystic Fibrosis
Therapeutic efficacy and safety of amitriptyline in patients with cystic fibrosis.
Cysts
TNF-alpha enhances Toxoplasma gondii cyst formation in human fibroblasts through the sphingomyelinase pathway.
Deafness
Partial sphingomyelinase deficiency with sea-blue histiocytosis and neurovisceral dysfunction.
Dehydration
Salinity Effects on Guard Cell Proteome in Chenopodium quinoa.
Dementia
Astrocytic ceramide as possible indicator of neuroinflammation.
Dementia
SMPD1 variants do not have a major role in rapid eye movement sleep behavior disorder.
Dementia
Sphingolipid metabolism correlates with cerebrospinal fluid Beta amyloid levels in Alzheimer's disease.
Dementia
The Roles of Neutral Sphingomyelinases in Neurological Pathologies.
Dementia
[Mutation del 1,02kb in the CLN3 gene and extrapyramidal syndrome].
Demyelinating Diseases
Acid sphingomyelinase deficiency enhances myelin repair after acute and chronic demyelination.
Dentinogenesis Imperfecta
A deletion in the gene encoding sphingomyelin phosphodiesterase 3 (Smpd3) results in osteogenesis and dentinogenesis imperfecta in the mouse.
Dentinogenesis Imperfecta
Upregulation of smpd3 via BMP2 stimulation and Runx2.
Dermatitis
Clostridium perfringens alpha-toxin and NetB toxin antibodies and their possible role in protection against necrotic enteritis and gangrenous dermatitis in broiler chickens.
Dermatitis, Atopic
Alpha-toxin is produced by skin colonizing Staphylococcus aureus and induces a T helper type 1 response in atopic dermatitis.
Dermatitis, Atopic
Association analysis of sphingomyelinase 2 polymorphisms for the extrinsic type of atopic dermatitis in Koreans.
Dermatitis, Atopic
Effects of sphingomyelin/ceramide ratio on the permeability and microstructure of model stratum corneum lipid membranes.
Dermatitis, Atopic
Impaired sphingomyelinase activity and epidermal differentiation in atopic dermatitis.
Dermatitis, Atopic
Localization of sphingomyelinase in lesional skin of atopic dermatitis patients.
Dermatitis, Atopic
Skin of atopic dermatitis patients shows disturbed ?-glucocerebrosidase and acid sphingomyelinase activity that relates to changes in stratum corneum lipid composition.
Dermatitis, Atopic
Staphylococcal alpha-toxin is a strong inducer of interleukin-17 in humans.
Dermatitis, Atopic
Staphylococcal toxins and protein A differentially induce cytotoxicity and release of tumor necrosis factor-alpha from human keratinocytes.
Diabetes Complications
SMPDL3b modulates insulin receptor signaling in diabetic kidney disease.
Diabetes Mellitus
Genome-Wide DNA Methylation Profiles of Phlegm-Dampness Constitution.
Diabetes Mellitus, Experimental
Effect of streptozotocin-diabetes on the functioning of the sphingomyelin-signalling pathway in skeletal muscles of the rat.
Diabetes Mellitus, Type 2
ApoCIII-enriched LDL in type 2 diabetes displays altered lipid composition, increased susceptibility for sphingomyelinase, and increased binding to biglycan.
Diabetes Mellitus, Type 2
Secretory Zn2+-dependent sphingomyelinase activity in the serum of patients with type 2 diabetes is elevated.
Diabetes Mellitus, Type 2
Sphingomyelinases and Liver Diseases.
Diabetic Nephropathies
SMPDL3b modulates insulin receptor signaling in diabetic kidney disease.
Diabetic Neuropathies
Alpha-mangostin attenuates diabetic nephropathy in association with suppression of acid sphingomyelianse and endoplasmic reticulum stress.
Diabetic Retinopathy
Role of acid sphingomyelinase in shifting the balance between pro-inflammatory and reparative bone marrow cells in diabetic retinopathy.
Digestive System Diseases
Alkaline sphingomyelinase (NPP7) in hepatobiliary diseases: A field that needs to be closely studied.
Digestive System Diseases
Purification of a newly identified alkaline sphingomyelinase in human bile and effects of bile salts and phosphatidylcholine on enzyme activity.
Diphtheria
Comparative study of immune status to infectious agents in elderly patients with multiple myeloma, Waldenstrom's macroglobulinemia, and monoclonal gammopathy of undetermined significance.
Diphtheria
The influence of bacterial exotoxins and endotoxins on the phagocytic activity of human macrophages in culture.
Diphtheria
Uptake of fluorochrome-labelled exotoxins by different cell types in culture.
Diphtheria
Use of silkworm larvae to study pathogenic bacterial toxins.
Drug-Related Side Effects and Adverse Reactions
Novel first-dose adverse drug reactions during a phase I trial of olipudase alfa (recombinant human acid sphingomyelinase) in adults with Niemann-Pick disease type B (acid sphingomyelinase deficiency).
Dwarfism
Neutral Sphingomyelinase (SMPD3) Deficiency Causes a Novel Form of Chondrodysplasia and Dwarfism That Is Rescued by Col2A1-Driven smpd3 Transgene Expression.
Dwarfism
Neutral sphingomyelinase (SMPD3) deficiency causes a novel form of chondrodysplasia and dwarfism that is rescued by Col2A1-driven smpd3 transgene expression.
Dwarfism
Neutral Sphingomyelinase 2 (SMPD3) Deficiency in Mice Causes Chondrodysplasia with Unimpaired Skeletal Mineralization.
Dwarfism
Neutral sphingomyelinase 2 (smpd3) in the control of postnatal growth and development.
Encephalitis
DPTIP, a newly identified potent brain penetrant neutral sphingomyelinase 2 inhibitor, regulates astrocyte-peripheral immune communication following brain inflammation.
Encephalomyelitis
Acid sphingomyelinase deficiency increases susceptibility to fatal alphavirus encephalomyelitis.
Encephalomyelitis
Combination of Imipramine, a sphingomyelinase inhibitor, and ?-caryophyllene improve their therapeutic effects on experimental autoimmune encephalomyelitis (EAE).
Encephalomyelitis
Pharmacological Inhibition of Acid Sphingomyelinase Ameliorates Experimental Autoimmune Encephalomyelitis.
Encephalomyelitis, Autoimmune, Experimental
Combination of Imipramine, a sphingomyelinase inhibitor, and ?-caryophyllene improve their therapeutic effects on experimental autoimmune encephalomyelitis (EAE).
Encephalomyelitis, Autoimmune, Experimental
Pharmacological Inhibition of Acid Sphingomyelinase Ameliorates Experimental Autoimmune Encephalomyelitis.
Endocarditis
Hyperproduction of alpha-toxin by Staphylococcus aureus results in paradoxically reduced virulence in experimental endocarditis: a host defense role for platelet microbicidal proteins.
Endocarditis
Regulation of Staphylococcus aureus alpha-toxin gene (hla) expression by agr, sarA, and sae in vitro and in experimental infective endocarditis.
Endocarditis
Serological diagnosis of deep Staphylococcus aureus infections by enzyme-linked immunosorbent assay (ELISA) for staphylococcal hemolysins and teichoic acid.
Endocarditis
Staphylococcal ?-Toxin Modulates Human Aortic Endothelial Cell and Platelet Function through Sphingomyelinase and Biofilm Ligase Activities.
Endocarditis
Staphylococcus aureus ?-Toxin Mutants Are Defective in Biofilm Ligase and Sphingomyelinase Activity, and Causation of Infective Endocarditis/Sepsis.
Endocarditis
Staphylococcus aureus ?-toxin Production is Common in Strains with the ?-toxin Gene Inactivated by Bacteriophage.
Endocarditis
The clinical significance of serological methods in the diagnosis of staphylococcal septicaemia and endocarditis.
Endocarditis
The role of antibodies against alpha-toxin and teichoic acid in the diagnosis of staphylococcal infections.
Endocarditis
Virulence factors of Staphylococcus aureus in the pathogenesis of endocarditis. A comparative study of clinical isolates.
Endocarditis, Subacute Bacterial
Dual function of human IgA antibodies: inhibition of phagocytosis in circulating neutrophils and enhancement of responses in IL-8-stimulated cells.
Endometritis
Necrotizing endometritis and isolation of an alpha-toxin producing strain of Clostridium septicum in a wild sooty mangabey from Côte d'Ivoire.
Enteritis
A bivalent vaccine against avian necrotic enteritis and coccidiosis.
Enteritis
A Fast and Inexpensive Protocol for Empirical Verification of Neutralizing Epitopes in Microbial Toxins and Enzymes.
Enteritis
A new cytotoxin from Bacillus cereus that may cause necrotic enteritis.
Enteritis
A Recombinant Probiotic, Lactobacillus casei, Expressing the Clostridium perfringens ?-toxoid, as an Orally Vaccine Candidate Against Gas Gangrene and Necrotic Enteritis.
Enteritis
Alpha-toxin of Clostridium perfringens is not an essential virulence factor in necrotic enteritis in chickens.
Enteritis
Application of an Endothelial Cell Culture Assay for the Detection of Neutralizing Anti-Clostridium Perfringens Beta-Toxin Antibodies in a Porcine Vaccination Trial.
Enteritis
Binding studies on isolated porcine small intestinal mucosa and in vitro toxicity studies reveal lack of effect of C. perfringens beta-toxin on the porcine intestinal epithelium.
Enteritis
Clostridium perfringens alpha toxin affects electrophysiological properties of isolated jejunal mucosa of laying hens.
Enteritis
Clostridium perfringens alpha-toxin and NetB toxin antibodies and their possible role in protection against necrotic enteritis and gangrenous dermatitis in broiler chickens.
Enteritis
Clostridium perfringens beta-toxin targets endothelial cells in necrotizing enteritis in piglets.
Enteritis
Clostridium perfringens {beta}-toxin binding to vascular endothelial cells in a human case of enteritis necroticans.
Enteritis
Comparison of chicken gut colonisation by the pathogens Campylobacter jejuni and Clostridium perfringens by real-time quantitative PCR.
Enteritis
Diagnosis of Clostridium perfringens type C enteritis in pigs using a DNA amplification technique (PCR).
Enteritis
Epsilon-toxin production by Clostridium perfringens type D strain CN3718 is dependent upon the agr operon but not the VirS/VirR two-component regulatory system.
Enteritis
Highly conserved alpha-toxin sequences of avian isolates of Clostridium perfringens.
Enteritis
Identification and cloning of two immunogenic Clostridium perfringens proteins, elongation factor Tu (EF-Tu) and pyruvate:ferredoxin oxidoreductase (PFO) of C. perfringens.
Enteritis
Identification of changes in the composition of ileal bacterial microbiota of broiler chickens infected with Clostridium perfringens.
Enteritis
In vitro inhibitory effect of hen egg white lysozyme on Clostridium perfringens type A associated with broiler necrotic enteritis and its alpha-toxin production.
Enteritis
Involvement of tumour necrosis factor-alpha in Clostridium perfringens beta-toxin-induced plasma extravasation in mice.
Enteritis
Molecular docking analysis of P2X7 receptor with the beta toxin from Clostridium perfringens.
Enteritis
NetB, a New Toxin That Is Associated with Avian Necrotic Enteritis Caused by Clostridium perfringens.
Enteritis
Quantification of Cell Proliferation and Alpha-Toxin Gene Expression of Clostridium perfringens in the Development of Necrotic Enteritis in Broiler Chickens.
Enteritis
Rapid Cytopathic Effects of C. perfringens Beta-Toxin on Porcine Endothelial Cells.
Enteritis
Relative disease susceptibility and clostridial toxin antibody responses in three commercial broiler lines coinfected with Clostridium perfringens and Eimeria maxima using an experimental model of necrotic enteritis.
Enteritis
Role of P2X7 receptor in Clostridium perfringens beta-toxin-mediated cellular injury.
Enteritis
Sandwich ELISA detection of Clostridium perfringens cells and alpha-toxin from field cases of necrotic enteritis of poultry.
Enteritis
Sequence variation in the alpha-toxin encoding plc gene of Clostridium perfringens strains isolated from diseased and healthy chickens.
Enteritis
Susceptibility of primary human endothelial cells to C. perfringens beta-toxin suggesting similar pathogenesis in human and porcine necrotizing enteritis.
Enteritis
The Clostridium perfringensalpha-toxin.
Enteritis
The p38 MAPK and JNK Pathways Protect Host Cells against Clostridium perfringens Beta-Toxin.
Enteritis
Variable protection against experimental broiler necrotic enteritis after immunisation with the C-terminal fragment of Clostridium perfringens alpha-toxin and a non-toxic NetB variant.
Enteritis
[The necrotizing enteritis by Clostridium perfringens type C in piglets: II. Molecular epidemiology study]
Enterocolitis
Role of pannexin 1 in Clostridium perfringens beta-toxin-caused cell death.
Enterocolitis, Necrotizing
Clostridium septicum alpha-toxin forms pores and induces rapid cell necrosis.
Enterocolitis, Necrotizing
Human meconium contains significant amounts of alkaline sphingomyelinase, neutral ceramidase, and sphingolipid metabolites.
Enterocolitis, Necrotizing
Recent Insights into Clostridium perfringens Beta-Toxin.
Enterotoxemia
Clostridium perfringens toxin types in hooded seals in the Greenland Sea, determined by PCR and ELISA.
Enterotoxemia
Epsilon-toxin production by Clostridium perfringens type D strain CN3718 is dependent upon the agr operon but not the VirS/VirR two-component regulatory system.
Enterotoxemia
Recent Insights into Clostridium perfringens Beta-Toxin.
Enterotoxemia
Role of P2X7 receptor in Clostridium perfringens beta-toxin-mediated cellular injury.
Enterotoxemia
Role of pannexin 1 in Clostridium perfringens beta-toxin-caused cell death.
Enterotoxemia
The enteric toxins of Clostridium perfringens.
Enterotoxemia
The p38 MAPK and JNK Pathways Protect Host Cells against Clostridium perfringens Beta-Toxin.
Erythema
Acute bacterial skin and skin structure infection: Critical role of alpha-toxin and protective effects of its neutralization by a human antibody.
Erythema
Brown spider phospholipase-D containing a conservative mutation (D233E) in the catalytic site: Identification and functional characterization.
Fabry Disease
A novel association between angiokeratoma corporis diffusum and acid sphingomyelinase deficiency.
Fabry Disease
Interstitial lung disease in lysosomal storage disorders.
Fabry Disease
Rapid screening for lipid storage disorders using biochemical markers. Expert center data and review of the literature.
Fabry Disease
Reconstruction of the Cytokine Signaling in Lysosomal Storage Diseases by Literature Mining and Network Analysis.
Farber Lipogranulomatosis
Acid Sphingomyelinase Deficiency Ameliorates Farber Disease.
Farber Lipogranulomatosis
My journey into the world of sphingolipids and sphingolipidoses.
Farber Lipogranulomatosis
On-tissue localization of ceramides and other sphingolipids by MALDI mass spectrometry imaging.
Fatty Liver
Acid sphingomyelinase deficiency in Western diet-fed mice protects against adipocyte hypertrophy and diet-induced liver steatosis.
Fatty Liver
Alcoholic and non-alcoholic fatty liver disease: Focus on ceramide.
Fatty Liver
ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis.
Fatty Liver
Metabolic therapy: lessons from liver diseases.
Fatty Liver
Sphingolipids and hepatic steatosis.
Fatty Liver, Alcoholic
Serum acid sphingomyelinase is upregulated in chronic hepatitis C infection and non alcoholic fatty liver disease.
Fibrosarcoma
Ceramide triggers p53-dependent apoptosis in genetically defined fibrosarcoma tumour cells.
Fibrosarcoma
Host acid sphingomyelinase regulates microvascular function not tumor immunity.
Fibrosarcoma
Role of Acid Sphingomyelinase and Ceramide in Mechano-Acoustic Enhancement of Tumor Radiation Responses.
Fibrosarcoma
Tumor response to radiotherapy regulated by endothelial cell apoptosis.
Foodborne Diseases
Clostridium Perfringens Bacteremia with Acute Hemolytic Anemia in the Setting of Endometrial Malignancy.
Foodborne Diseases
Isolation of Alpha-Toxin-Deficient Clostridium perfringens Type F from Sewage Influents and Effluents.
Foodborne Diseases
Preparation and characterization of a human scFv against the Clostridium perfringens type A alpha-toxin.
Frontotemporal Lobar Degeneration
Astrocytic ceramide as possible indicator of neuroinflammation.
Furunculosis
Sphingomyelinase activity of Staphylococcus aureus strains from recurrent furunculosis and other infections.
Gangliosidosis, GM1
Bi-functional IgG-lysosomal enzyme fusion proteins for brain drug delivery.
Gangliosidosis, GM1
Ito cells in lysosomal storage disorders. An ultrastructural study.
Gas Gangrene
A cellular deficiency of gangliosides causes hypersensitivity to Clostridium perfringens phospholipase C.
Gas Gangrene
A genetically engineered vaccine against the alpha-toxin of Clostridium perfringens protects mice against experimental gas gangrene.
Gas Gangrene
A recombinant carboxy-terminal domain of alpha-toxin protects mice against Clostridium perfringens.
Gas Gangrene
A Recombinant Probiotic, Lactobacillus casei, Expressing the Clostridium perfringens ?-toxoid, as an Orally Vaccine Candidate Against Gas Gangrene and Necrotic Enteritis.
Gas Gangrene
Amentoflavone Attenuates Clostridium perfringens Gas Gangrene by Targeting Alpha-Toxin and Perfringolysin O.
Gas Gangrene
Clostridial glucosylating toxins enter cells via clathrin-mediated endocytosis.
Gas Gangrene
Clostridium absonum alpha-toxin: new insights into clostridial phospholipase C substrate binding and specificity.
Gas Gangrene
Clostridium perfringens Alpha-Toxin Induces Gm1a Clustering and Trka Phosphorylation in the Host Cell Membrane.
Gas Gangrene
Clostridium perfringens alpha-toxin induces rabbit neutrophil adhesion.
Gas Gangrene
Clostridium perfringens Alpha-toxin Recognizes the GM1a/TrkA Complex.
Gas Gangrene
Clostridium perfringens alpha-toxin: characterization and mode of action.
Gas Gangrene
Clostridium Perfringens Bacteremia with Acute Hemolytic Anemia in the Setting of Endometrial Malignancy.
Gas Gangrene
Clostridium septicum alpha-toxin forms pores and induces rapid cell necrosis.
Gas Gangrene
Cross-complementation of Clostridium perfringens PLC and Clostridium septicum alpha-toxin mutants reveals PLC is sufficient to mediate gas gangrene.
Gas Gangrene
Crystallization and preliminary X-ray diffraction studies of alpha-toxin from two different strains (NCTC8237 and CER89L43) of Clostridium perfringens.
Gas Gangrene
Effect of erythromycin on biological activities induced by clostridium perfringens alpha-toxin.
Gas Gangrene
Effects of Clostridium perfringens alpha-toxin (PLC) and perfringolysin O (PFO) on cytotoxicity to macrophages, on escape from the phagosomes of macrophages, and on persistence of C. perfringens in host tissues.
Gas Gangrene
Effects of Clostridium perfringens phospholipase C in mammalian cells.
Gas Gangrene
Identification of residues critical for toxicity in Clostridium perfringens phospholipase C, the key toxin in gas gangrene.
Gas Gangrene
Isolation of alpha-toxin, theta-toxin and kappa-toxin mutants of Clostridium perfringens by Tn916 mutagenesis.
Gas Gangrene
Large clostridial cytotoxins: cellular biology of Rho/Ras-glucosylating toxins.
Gas Gangrene
Lipidomic profile of GM95 cell death induced by Clostridium perfringens alpha-toxin.
Gas Gangrene
Membrane-Binding Mechanism of Clostridium perfringens Alpha-Toxin.
Gas Gangrene
Perfringolysin O expression in Clostridium perfringens is independent of the upstream pfoR gene.
Gas Gangrene
Phospholipase C and sphingomyelinase activities of the Clostridium perfringens alpha-toxin.
Gas Gangrene
Preparation and characterization of a human scFv against the Clostridium perfringens type A alpha-toxin.
Gas Gangrene
Role of tyrosine-57 and -65 in membrane-damaging and sphingomyelinase activities of Clostridium perfringens alpha-toxin.
Gas Gangrene
Structure of the gangrene alpha-toxin: the beauty in the beast.
Gas Gangrene
Structure of the key toxin in gas gangrene.
Gas Gangrene
Synergistic effects of alpha-toxin and perfringolysin O in Clostridium perfringens-mediated gas gangrene.
Gas Gangrene
The biochemistry of the gas gangrene toxins: 4. The reaction between the alpha-toxin (lecithinase) of Clostridium welchii and its antitoxin.
Gas Gangrene
The biochemistry of the gas gangrene toxins; the reaction between the alpha-toxin, lecithinase, of Clostridium welchii and its antitoxin.
Gas Gangrene
The Clostridium perfringensalpha-toxin.
Gas Gangrene
The first strain of Clostridium perfringens isolated from an avian source has an alpha-toxin with divergent structural and kinetic properties.
Gas Gangrene
The NanI and NanJ sialidases of Clostridium perfringens are not essential for virulence.
Gas Gangrene
The Oncopathic Potency of Clostridium perfringens Is Independent of Its alpha-Toxin Gene.
Gas Gangrene
The role of alpha-toxin of Clostridium perfringens in experimental gas gangrene in guinea pigs.
Gas Gangrene
Use of genetically manipulated strains of Clostridium perfringens reveals that both alpha-toxin and theta-toxin are required for vascular leukostasis to occur in experimental gas gangrene.
Gas Gangrene
Vaccines against Clostridium perfringens alpha-toxin.
Gas Gangrene
Virulence studies on chromosomal alpha-toxin and theta-toxin mutants constructed by allelic exchange provide genetic evidence for the essential role of alpha-toxin in Clostridium perfringens-mediated gas gangrene.
Gas Gangrene
[Characteristics of alpha-toxin of Clostridium perfringens and its role in the pathogenesis of gas gangrene (author's transl)]
Gas Gangrene
[Toxigenesis of Clostridium onvyi type A. 1. Communication: production of alpha-toxin in vitro (author's transl)]
Gaucher Disease
Gaucher and Niemann-Pick diseases--enzymatic diagnosis in dried blood spots on filter paper: retrospective diagnoses in newborn-screening cards.
Gaucher Disease
Interstitial lung disease in lysosomal storage disorders.
Gaucher Disease
Plasma chitotriosidase and CCL18: early biochemical surrogate markers in type B Niemann-Pick disease.
Gaucher Disease
Preliminary evidence for a processing error in the biosynthesis of Gaucher activator in mucolipidosis disease types II and III.
Gaucher Disease
Prenatal diagnosis of Gaucher's and Niemann-Pick diseases. Assays of glucocerebrosidase and sphingomyelinase in tissue cultures using natural substrates.
Gaucher Disease
Reconstruction of the Cytokine Signaling in Lysosomal Storage Diseases by Literature Mining and Network Analysis.
Gaucher Disease
Studies on the activation of sphingomyelinase activity in Niemann-Pick type A, B, and C fibroblasts: enzymological differentiation of types A and B.
Genetic Diseases, Inborn
Combined Emphysema and Interstitial Lung Disease as a Rare Presentation of Pulmonary Involvement in a Patient with Chronic Visceral Acid Sphingomyelinase Deficiency (Niemann-Pick Disease Type B).
Genetic Diseases, Inborn
Connecting Hsp70, sphingolipid metabolism and lysosomal stability.
Genetic Diseases, Inborn
Disease manifestations and burden of illness in patients with acid sphingomyelinase deficiency (ASMD).
Genetic Diseases, Inborn
Identification and biochemical characterization of an acid sphingomyelinase-like protein from the bacterial plant pathogen Ralstonia solanacearum that hydrolyzes ATP to AMP but not sphingomyelin to ceramide.
Genetic Diseases, Inborn
Niemann-Pick disease type-B: a unique case report with compound heterozygosity and complicated lipid management.
Genetic Diseases, Inborn
Sperm Abnormalities in Heterozygous Acid Sphingomyelinase Knockout Mice Reveal a Novel Approach for the Prevention of Genetic Diseases.
Genetic Diseases, Inborn
Sperm abnormalities in heterozygous acid sphingomyelinase knockout mice reveal a novel approach for the prevention of genetic diseases.
Glioblastoma
Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death.
Glioma
Acid sphingomyelinase activation requires caspase-8 but not p53 nor reactive oxygen species during Fas-induced apoptosis in human glioma cells.
Glioma
Acidic sphingomyelinase: relationship with antidepressant-induced desensitization of beta-adrenoceptors.
Glioma
Antidepressant-induced lipidosis with special reference to tricyclic compounds.
Glioma
Calmodulin antagonist W-7 inhibits lysosomal sphingomyelinase activity in C6 glioma cells.
Glioma
Ceramide metabolism determines glioma cell resistance to chemotherapy.
Glioma
Channelling of intermediates in the biosynthesis of phosphatidylcholine and phosphatidylethanolamine in mammalian cells.
Glioma
Effect of tricyclic antidepressants on sphingomyelinase and other sphingolipid hydrolases in C6 cultured glioma cells.
Glioma
Influence of Bax or Bcl-2 overexpression on the ceramide-dependent apoptotic pathway in glioma cells.
Glioma
Lysosomal ceramide mediates gemcitabine-induced death of glioma cells.
Glioma
Modifications of sphingomyelin and phosphatidylcholine metabolism by tricyclic antidepressants and phenothiazines.
Glioma
Neutral sphingomyelinase activation in endothelial and glial cell death induced by amyloid beta-peptide.
Glioma
Overexpression of acid sphingomyelinase sensitizes glioma cells to chemotherapy.
Glioma
p53 regulates ceramide formation by neutral sphingomyelinase through reactive oxygen species in human glioma cells.
Glioma
p53-Independent ceramide formation in human glioma cells during gamma-radiation-induced apoptosis.
Glioma
Penta-acetyl geniposide-induced apoptosis involving transcription of NGF/p75 via MAPK-mediated AP-1 activation in C6 glioma cells.
glucosylceramidase deficiency
Preliminary evidence for a processing error in the biosynthesis of Gaucher activator in mucolipidosis disease types II and III.
Graft vs Host Disease
Acid sphingomyelinase deficiency does not protect from graft-versus-host disease in transplant recipients with Niemann-Pick disease.
Graft vs Host Disease
Bone marrow transplantation for Niemann-Pick type IA disease.
Graft vs Host Disease
Successful hematopoietic stem cell transplantation for Niemann-Pick disease type B.
Granuloma
Fusogenicity of membranes: the impact of acid sphingomyelinase on innate immune responses.
Heart Failure
Adjustment of Dysregulated Ceramide Metabolism in a Murine Model of Sepsis-Induced Cardiac Dysfunction.
Heart Failure
Biosynthesis of constitutive nitric oxide synthase-derived nitric oxide attenuates coronary vasoconstriction and myocardial depression in a model of septic heart failure induced by Staphylococcus aureus alpha-toxin.
Heart Failure
Diaphragm dysfunction in heart failure is accompanied by increases in neutral sphingomyelinase activity and ceramide content.
Heart Failure
Neutral sphingomyelinase: past, present and future.
Heart Failure
Secretory sphingomyelinase is upregulated in chronic heart failure: a second messenger system of immune activation relates to body composition, muscular functional capacity, and peripheral blood flow.
Heart Failure
Short-term magnesium deficiency downregulates telomerase, upregulates neutral sphingomyelinase and induces oxidative DNA damage in cardiovascular tissues: relevance to atherogenesis, cardiovascular diseases and aging.
Heart Failure
Small hairpin RNA and pharmacological targeting of neutral sphingomyelinase prevents diaphragm weakness in rats with heart failure and reduced ejection fraction.
Heart Failure
Sphingolipids in atherosclerosis and vascular biology.
Heart Failure
Sphingomyelinase depresses force and calcium sensitivity of the contractile apparatus in mouse diaphragm muscle fibers.
Heart Failure
Sphingomyelinase stimulates oxidant signaling to weaken skeletal muscle and promote fatigue.
Heart Failure
Sphingomyelinases: their regulation and roles in cardiovascular pathophysiology.
Heart Failure
The Polycomb group protein EED couples TNF receptor 1 to neutral sphingomyelinase.
Hepatitis
Acidic sphingomyelinase downregulates the liver-specific methionine adenosyltransferase 1A, contributing to tumor necrosis factor-induced lethal hepatitis.
Hepatitis
Diagnosing Clostridium perfringens-associated necrotic enteritis in broiler flocks by an immunoglobulin G anti-alpha-toxin enzyme-linked immunosorbent assay.
Hepatitis C, Chronic
Serum acid sphingomyelinase is upregulated in chronic hepatitis C infection and non alcoholic fatty liver disease.
Hepatolenticular Degeneration
Liver cell death and anemia in Wilson disease involve acid sphingomyelinase and ceramide.
Herpes Simplex
Neutral sphingomyelinase-inhibiting guanidines prevent herpes simplex virus-1 replication.
Herpes Simplex
Role of Sphingomyelin in Alphaherpesvirus Entry.
Herpes Zoster
Relationship between endotoxin core, staphylococcal and varicella antibody levels and outcome following aortic valve replacement surgery: a prospective observational study.
Histiocytosis
Pathogenesis of one variant of sea-blue histiocytosis.
Histiocytosis
Splenic histiocytosis in idiopathic thrombocytopenic purpura: a relative sphingomyelinase deficiency?
HIV Infections
Sphingomyelinase restricts the lateral diffusion of CD4 and inhibits human immunodeficiency virus fusion.
Hyperalgesia
Analgesic Effects of Lipid Raft Disruption by Sphingomyelinase and Myriocin via Transient Receptor Potential Vanilloid 1 and Transient Receptor Potential Ankyrin 1 Ion Channel Modulation.
Hyperalgesia
Anti-allodynic effect of intracerebroventricularly administered antioxidant and free radical scavenger in a mouse model of orofacial pain.
Hyperalgesia
The p75(NTR) Signaling Cascade Mediates Mechanical Hyperalgesia Induced By Nerve Growth Factor Injected Into The Rat Hind Paw.
Hypercholesterolemia
Endothelial NLRP3 inflammasome activation and arterial neointima formation associated with acid sphingomyelinase during hypercholesterolemia.
Hyperglycemia
Acid Sphingomyelinase Deficiency Prevents Diet-induced Hepatic Triacylglycerol Accumulation and Hyperglycemia in Mice.
Hyperhomocysteinemia
Acid sphingomyelinase gene knockout ameliorates hyperhomocysteinemic glomerular injury in mice lacking cystathionine-?-synthase.
Hyperinsulinism
Altered adipose and plasma sphingolipid metabolism in obesity: a potential mechanism for cardiovascular and metabolic risk.
Hyperlipidemias
Modulation of Lipid Metabolism by Celastrol.
Hyperlipoproteinemia Type II
Impairment of exogenous sphingomyelin degradation in cultured fibroblasts from familial hypercholesterolemia.
Hyperphosphatemia
Barley-ß-glucans reduce systemic inflammation, renal injury and aortic calcification through ADAM17 and neutral-sphingomyelinase2 inhibition.
Hypersensitivity
The common acid sphingomyelinase polymorphism p.G508R is associated with self-reported allergy.
Hypersensitivity, Delayed
[Characteristics of a staphylococcal infection in guinea pigs with delayed hypersensitivity to staphylococcal alpha-toxin]
Hypertension
Membrane rafts-redox signalling pathway contributes to renal fibrosis via modulation of the renal tubular epithelial-mesenchymal transition.
Hypertension
Short-term magnesium deficiency downregulates telomerase, upregulates neutral sphingomyelinase and induces oxidative DNA damage in cardiovascular tissues: relevance to atherogenesis, cardiovascular diseases and aging.
Hypertension
Staphylococcal alpha-toxin elicits hypertension in isolated rabbit lungs. Evidence for thromboxane formation and the role of extracellular calcium.
Hypertension
Staphylococcal alpha-toxin-induced vascular leakage in isolated perfused rabbit lungs.
Hypertension, Pulmonary
Endotoxin primes perfused rabbit lungs for enhanced vasoconstrictor response to staphylococcal alpha-toxin.
Hyperthyroidism
Long- and short-term effects of thyroxine on sphingolipid metabolism in rat liver.
Hypertriglyceridemia
Compound heterozygosity at the sphingomyelin phosphodiesterase-1 (SMPD1) gene is associated with low HDL cholesterol.
Impetigo
Staphylococcal scalded skin syndrome. II. Serum level of anti exfoliatin and anti alpha-toxin in patients with staphylococcal scalded skin syndrome or bullous impetigo.
Infarction, Middle Cerebral Artery
Homozygous Smpd1 deficiency aggravates brain ischemia/ reperfusion injury by mechanisms involving polymorphonuclear neutrophils, whereas heterozygous Smpd1 deficiency protects against mild focal cerebral ischemia.
Infections
A high-throughput sphingomyelinase assay using natural substrate.
Infections
Accumulation of aquaporin-1 during hemolysin-induced necrotic cell death.
Infections
Acid sphingomyelinase amplifies redox signaling in Pseudomonas aeruginosa-induced macrophage apoptosis.
Infections
Acid Sphingomyelinase Contributes to the Control of Mycobacterial Infection via a Signaling Cascade Leading from Reactive Oxygen Species to Cathepsin D.
Infections
Acid sphingomyelinase deficiency increases susceptibility to fatal alphavirus encephalomyelitis.
Infections
Acid Sphingomyelinase Inhibitors Normalize Pulmonary Ceramide and Inflammation in Cystic Fibrosis.
Infections
Acid Sphingomyelinase-Ceramide System in Bacterial Infections.
Infections
Acute bacterial skin and skin structure infection: Critical role of alpha-toxin and protective effects of its neutralization by a human antibody.
Infections
Alpha-toxin facilitates the generation of CXC chemokine gradients and stimulates neutrophil homing in Staphylococcus aureus pneumonia.
Infections
Alpha-toxin induces programmed cell death of human T cells, B cells, and monocytes during USA300 infection.
Infections
Alterations in ceramide concentration and pH determine the release of reactive oxygen species by Cftr-deficient macrophages on infection.
Infections
An acidic sphingomyelinase Type C activity from Mycobacterium tuberculosis.
Infections
Analysis of the effect of Sphingomyelinase on rubellavirus infectivity in two cell lines.
Infections
Anti-alpha-toxin monoclonal antibody and antibiotic combination therapy improves disease outcome and accelerates healing in a Staphylococcus aureus dermonecrosis model.
Infections
ASMase: the tailor of cytotoxic T cell granule exocytosis.
Infections
Association between antidepressant use and reduced risk of intubation or death in hospitalized patients with COVID-19: results from an observational study.
Infections
Bilateral Cystic Bronchiectasis as Novel Phenotype of Niemann-Pick Disease Type B Successfully Treated With Double Lung Transplantation.
Infections
Biological effects of the interaction of staphylococcal alpha-toxin with human serum.
Infections
Ceramide and sphingosine in pulmonary infections.
Infections
Ceramide in Pseudomonas aeruginosa infections and cystic fibrosis.
Infections
Ceramide plays a prominent role in MDA-7/IL-24-induced cancer-specific apoptosis.
Infections
Ceramide, a target for antiretroviral therapy.
Infections
Ceramide-enriched membrane domains.
Infections
Clostridium perfringens alpha toxin affects electrophysiological properties of isolated jejunal mucosa of laying hens.
Infections
Clostridium perfringens alpha-toxin: characterization and mode of action.
Infections
Co-option of Membrane Wounding Enables Virus Penetration into Cells.
Infections
Construction and virulence testing of a collagenase mutant of Clostridium perfringens.
Infections
Corneal virulence of Staphylococcus aureus: roles of alpha-toxin and protein A in pathogenesis.
Infections
Deciphering the Pathological Role of Staphylococcal ?-Toxin and Panton-Valentine Leukocidin Using a Novel Ex Vivo Human Skin Model.
Infections
Decreased plasma phospholipid concentrations and increased acid sphingomyelinase activity are accurate biomarkers for community-acquired pneumonia.
Infections
Decreasing SMPD1 activity in BEAS-2B bronchial airway epithelial cells results in increased NRF2 activity, cytokine synthesis and neutrophil recruitment.
Infections
Defective Acid Sphingomyelinase Pathway with Pseudomonas aeruginosa Infection in Cystic Fibrosis.
Infections
Depletion of Host and Viral Sphingomyelin Impairs Influenza Virus Infection.
Infections
Detection of neutralizing antibodies against alpha-toxin of different Clostridium septicum strains in cell culture.
Infections
Drosophila melanogaster as a model host for Staphylococcus aureus infection.
Infections
Ebolavirus requires acid sphingomyelinase activity and plasma membrane sphingomyelin for infection.
Infections
Effect of 2 Emulsion-Based Adjuvants on the Structure and Thermal Stability of Staphylococcus aureus Alpha-Toxin.
Infections
Effects of amoxicillin, gentamicin, and moxifloxacin on the hemolytic activity of Staphylococcus aureus in vitro and in vivo.
Infections
Effects of Clostridium perfringens alpha-toxin (PLC) and perfringolysin O (PFO) on cytotoxicity to macrophages, on escape from the phagosomes of macrophages, and on persistence of C. perfringens in host tissues.
Infections
Effects of Mycoplasma pneumoniae infection on sphingolipid metabolism in human lung carcinoma A549 cells.
Infections
Efficacy of a Multimechanistic Monoclonal Antibody Combination against Staphylococcus aureus Surgical Site Infections in Mice.
Infections
Enterotoxic Clostridia: Clostridium perfringens Enteric Diseases.
Infections
Evaluation of the Expression and Protective Potential of Leptospiral Sphingomyelinases.
Infections
Ex vivo assay to evaluate the efficacy of drugs targeting sphingolipids in preventing SARS-CoV-2 infection of nasal epithelial cells.
Infections
Exosomes mediate Zika virus transmission through SMPD3 neutral Sphingomyelinase in cortical neurons.
Infections
Expression of recombinant human acid sphingomyelinase in insect Sf21 cells: purification, processing and enzymatic characterization.
Infections
Factor associated with neutral sphingomyelinase activity mediates navigational capacity of leukocytes responding to wounds and infection: live imaging studies in zebrafish larvae.
Infections
Functional inhibition of acid sphingomyelinase disrupts infection by intracellular bacterial pathogens.
Infections
Functional inhibition or genetic deletion of acid sphingomyelinase bacteriostatically inhibits Anaplasma phagocytophilum infection in vivo.
Infections
Fusogenicity of membranes: the impact of acid sphingomyelinase on innate immune responses.
Infections
Group B streptococcus induces trophoblast death.
Infections
Hemolysin and K antigens in relation to serotype and hemagglutination type of Escherichia coli isolated from extraintestinal infections.
Infections
Heterogeneity of hemolysin expression during neonatal Streptococcus agalactiae sepsis.
Infections
High-level over-expression, purification, and crystallization of a novel phospholipase C/sphingomyelinase from Pseudomonas aeruginosa.
Infections
Host defense against Pseudomonas aeruginosa requires ceramide-rich membrane rafts.
Infections
Host sphingomyelin increases West Nile virus infection in vivo.
Infections
Immune recruitment and bactericidal activity of neutrophils in milk of cows vaccinated with staphylococcal alpha-toxin.
Infections
Immunohistochemical localization of Clostridium perfringens beta2-toxin in the gastrointestinal tract of horses.
Infections
Impact of the regulatory loci agr, sarA and sae of Staphylococcus aureus on the induction of alpha-toxin during device-related infection resolved by direct quantitative transcript analysis.
Infections
Incorporation of staphylococcal alpha-toxin in glutaraldehyde fixed erythrocytes.
Infections
Influence of amitriptyline on eryptosis, parasitemia and survival of Plasmodium berghei-infected mice.
Infections
Inhibition of acid sphingomyelinase by ambroxol prevents SARS-CoV-2 entry into epithelial cells.
Infections
Inhibition of chemokine receptor function by membrane cholesterol oxidation.
Infections
Inhibition of neutral sphingomyelinase protects mice against systemic tuberculosis.
Infections
Involvement of ceramide in the propagation of Japanese encephalitis virus.
Infections
Involvement of mitogen-activated protein kinases in Group B Streptococcus-induced macrophage apoptosis.
Infections
Isolation of alpha-toxin, theta-toxin and kappa-toxin mutants of Clostridium perfringens by Tn916 mutagenesis.
Infections
Keep Your Friends Close, but Your Enemies Closer: Role of Acid Sphingomyelinase During Infection and Host Response.
Infections
Leishmania-induced biphasic ceramide generation in macrophages is crucial for uptake and survival of the parasite.
Infections
Lipase versus teichoic acid and alpha-toxin as antigen in an enzyme immunoassay for serological diagnosis of Staphylococcus aureus infections.
Infections
Live attenuated vaccine-based control of necrotic enteritis of broiler chickens.
Infections
Local delivery of soluble interleukin-6 receptors to improve the outcome of alpha-toxin producing Staphylococcus aureus infection in mice.
Infections
Mechanism of leukotriene generation in polymorphonuclear leukocytes by staphylococcal alpha-toxin.
Infections
Membrane-Binding Mechanism of Clostridium perfringens Alpha-Toxin.
Infections
Modulation of enzymatic activity and biological function of Listeria monocytogenes broad-range phospholipase C by amino acid substitutions and by replacement with the Bacillus cereus ortholog.
Infections
Mycobacterial Infection is Promoted by Neutral Sphingomyelinase 2 Regulating a Signaling Cascade Leading to Activation of ?1-Integrin.
Infections
Novel inhibitor of bacterial sphingomyelinase, SMY-540, developed based on three-dimensional structure analysis.
Infections
Oligomer formation of Clostridium perfringens epsilon-toxin is induced by activation of neutral sphingomyelinase.
Infections
Pharmacological Inhibition of Acid Sphingomyelinase Prevents Uptake of SARS-CoV-2 by Epithelial Cells.
Infections
Precipitating antibodies against Staphylococcus aureus in experimental rabbit osteomyelitis, investigated by means of quantitative immunoelectrophoretic methods.
Infections
Production and applications of an N-terminally-truncated recombinant beta-haemolysin from Staphylococcus aureus.
Infections
Purification and characterization of neutral sphingomyelinase from Helicobacter pylori.
Infections
Raft ceramide in molecular medicine.
Infections
Recent Insights into Clostridium perfringens Beta-Toxin.
Infections
Regulated antisense RNA eliminates alpha-toxin virulence in Staphylococcus aureus infection.
Infections
Regulation of Staphylococcus aureus Infection of Macrophages by CD44, Reactive Oxygen Species, and Acid Sphingomyelinase.
Infections
Repurposing functional inhibitors of acid sphingomyelinase (fiasmas): an opportunity against SARS-CoV-2 infection?
Infections
Rhinoviruses infect human epithelial cells via ceramide-enriched membrane platforms.
Infections
Role of acid sphingomyelinase and IL-6 as mediators of endotoxin-induced pulmonary vascular dysfunction.
Infections
Role of alpha-toxin in Clostridium perfringens infection determined by using recombinants of C. perfringens and Bacillus subtilis.
Infections
Role of Sphingomyelin in Alphaherpesvirus Entry.
Infections
Role of Sphingomyelinase in the Pathogenesis of Bacillus cereus Infection.
Infections
SARS-CoV-2 infection induces the activation of tissue factor-mediated coagulation via activation of acid sphingomyelinase.
Infections
Serum acid sphingomyelinase is upregulated in chronic hepatitis C infection and non alcoholic fatty liver disease.
Infections
Specific roles of alpha-toxin and beta-toxin during Staphylococcus aureus corneal infection.
Infections
Sphingomyelinase activity of Staphylococcus aureus strains from recurrent furunculosis and other infections.
Infections
Staphylococcal alpha-toxin-induced vascular leakage in isolated perfused rabbit lungs.
Infections
Staphylococcus aureus ?-toxin Production is Common in Strains with the ?-toxin Gene Inactivated by Bacteriophage.
Infections
Staphylococcus aureus Alpha-Toxin Limits Type 1 While Fostering Type 3 Immune Responses.
Infections
Staphylococcus aureus alpha-toxin mediates general and cell type-specific changes in metabolite concentrations of immortalized human airway epithelial cells.
Infections
Staphylococcus aureus Biofilms Induce Macrophage Dysfunction Through Leukocidin AB and Alpha-Toxin.
Infections
Staphylococcus aureus in chronic and recurrent infections.
Infections
Staphylococcus corneal virulence in a new topical model of infection.
Infections
Streptococcus iniae beta-hemolysin streptolysin S is a virulence factor in fish infection.
Infections
Sub-Inhibitory Concentrations of Mupirocin Strongly Inhibit Alpha-Toxin Production in High-Level Mupirocin-Resistant MRSA by Down-Regulating agr, saeRS, and sarA.
Infections
Synergistic effects of alpha-toxin and perfringolysin O in Clostridium perfringens-mediated gas gangrene.
Infections
T Cell-Specific Overexpression of Acid Sphingomyelinase Results in Elevated T Cell Activation and Reduced Parasitemia During Plasmodium yoelii Infection.
Infections
The association of CD81 with tetraspanin-enriched microdomains is not essential for Hepatitis C virus entry.
Infections
The H35A mutated alpha-toxin interferes with cytotoxicity of staphylococcal alpha-toxin.
Infections
The psm? locus regulates production of Staphylococcus aureus alpha-toxin during infection.
Infections
The role of antibodies against alpha-toxin and teichoic acid in the diagnosis of staphylococcal infections.
Infections
The Role of hlb-Converting Bacteriophages in Staphylococcus aureus Host Adaption.
Infections
The role of humoral immunity and acute inflammation in protection against staphyloccocal dermonecrosis.
Infections
Therapeutic efficacy and safety of amitriptyline in patients with cystic fibrosis.
Infections
Therapy of CF-patients with amitriptyline and placebo--a randomised, double-blind, placebo-controlled phase IIb multicenter, cohort-study.
Infections
Trypanosoma cruzi modulates gene expression of plasma membrane repair-related proteins.
Infections
Vaccines against Clostridium perfringens alpha-toxin.
Infections
Zika virus propagation and release in human fetal astrocytes can be suppressed by neutral sphingomyelinase-2 inhibitor GW4869.
Infections
[Structure and function of sphingomyelinase]
Infections
[The necrotizing enteritis by Clostridium perfringens type C in piglets: practical observations, control and epidemiology]
Inflammatory Bowel Diseases
Acid sphingomyelinase inhibition suppresses lipopolysaccharide-mediated release of inflammatory cytokines from macrophages and protects against disease pathology in dextran sulphate sodium-induced colitis in mice.
Inflammatory Bowel Diseases
Alkaline sphingomyelinase: an old enzyme with novel implications.
Inflammatory Bowel Diseases
Boswellic acid inhibits expression of acid sphingomyelinase in intestinal cells.
Inflammatory Bowel Diseases
Inhibition of lipopolysaccharide-induced release of interleukin-8 from intestinal epithelial cells by SMA, a novel inhibitor of sphingomyelinase and its therapeutic effect on dextran sulphate sodium-induced colitis in mice.
Inflammatory Bowel Diseases
Ursolic Acid Inhibits Acid Sphingomyelinase in Intestinal Cells.
Influenza, Human
Differential role of sphingomyelin in influenza virus, rhinovirus and SARS-CoV-2 infection of Calu-3 cells.
Influenza, Human
Linezolid Attenuates Lethal Lung Damage during Postinfluenza Methicillin-Resistant Staphylococcus aureus Pneumonia.
Influenza, Human
Targeting the endolysosomal host-SARS-CoV-2 interface by clinically licensed functional inhibitors of acid sphingomyelinase (FIASMA) including the antidepressant fluoxetine.
Insulin Resistance
Acid Sphingomyelinase Deficiency Prevents Diet-induced Hepatic Triacylglycerol Accumulation and Hyperglycemia in Mice.
Insulin Resistance
Acid Sphingomyelinase Down-regulation Alleviates Vascular Endothelial Insulin Resistance in Diabetic Rats.
Insulin Resistance
Ceramide content is increased in skeletal muscle from obese insulin-resistant humans.
Insulin Resistance
Common inhibitory serine sites phosphorylated by IRS-1 kinases, triggered by insulin and inducers of insulin resistance.
Insulin Resistance
Genome-Wide DNA Methylation Profiles of Phlegm-Dampness Constitution.
Insulin Resistance
High fat diet induced hepatic steatosis and insulin resistance: Role of dysregulated ceramide metabolism.
Insulin Resistance
Inhibition of neutral sphingomyelinases in skeletal muscle attenuates fatty-acid induced defects in metabolism and stress.
Insulin Resistance
Sortilin deficiency improves the metabolic phenotype and reduces hepatic steatosis of mice subjected to diet-induced obesity.
Insulin Resistance
Tumor necrosis factor-alpha, sphingomyelinase and ceramides activate tyrosine kinase, p21Ras and phosphatidylinositol 3-kinase: implications for glucose transport and insulin resistance.
Insulin Resistance
[ROLE OF NEUTRAL SPHINGOMYELINASE IN AGE-DEPENDENT MUSCLE INSULIN RESISTANCE DEVELOPMENT AND ITS IMPROVEMENT WITH N-ACETYLCYSTEINE].
Insulinoma
The acid sphingomyelinase inhibitor SR33557 counteracts TNF-alpha-mediated potentiation of IL-1beta-induced NF-kappaB activation in the insulin-producing cell line Rinm5F.
Insulinoma
The group VIA calcium-independent phospholipase A2 participates in ER stress-induced INS-1 insulinoma cell apoptosis by promoting ceramide generation via hydrolysis of sphingomyelins by neutral sphingomyelinase.
Intellectual Disability
Chronic Niemann-Pick disease with sphingomyelinase deficiency in two brothers with mental retardation.
Intellectual Disability
Synaptic vesicle docking: sphingosine regulates syntaxin1 interaction with Munc18.
Intestinal Diseases
Immunohistochemical localization of Clostridium perfringens beta2-toxin in the gastrointestinal tract of horses.
Intestinal Neoplasms
Detection of alkaline sphingomyelinase activity in human stool: proposed role as a new diagnostic and prognostic marker of colorectal cancer.
Intestinal Neoplasms
Regulatory T cells reduce endothelial neutral sphingomyelinase 2 to prevent T-cell migration into tumors.
Intraabdominal Infections
Candida albicans Impacts Staphylococcus aureus Alpha-Toxin Production via Extracellular Alkalinization.
Iritis
Specific roles of alpha-toxin and beta-toxin during Staphylococcus aureus corneal infection.
Keratitis
Age-Related Differences in Rabbits during Experimental Staphylococcus aureus Keratitis.
Keratitis
Comparison of potential pathogenic traits of staphylococci that may contribute to corneal ulceration and inflammation.
Keratitis
Corneal pathogenesis of Staphylococcus aureus strain Newman.
Keratitis
Corneal virulence of Staphylococcus aureus: roles of alpha-toxin and protein A in pathogenesis.
Keratitis
Effectiveness of Alpha-toxin Fab Monoclonal Antibody Therapy in Limiting the Pathology of Staphylococcus aureus Keratitis.
Keratitis
Effects of toxin production in a murine model of Staphylococcus aureus keratitis.
Keratitis
Histopathological studies of staphylococcal alpha-toxin: effects on rabbit corneas.
Keratitis
Host defense against bacterial keratitis.
Keratitis
Immunization with alpha-toxin toxoid protects the cornea against tissue damage during experimental Staphylococcus aureus keratitis.
Keratitis
Specific roles of alpha-toxin and beta-toxin during Staphylococcus aureus corneal infection.
Keratitis
Staphylococcus corneal virulence in a new topical model of infection.
Kidney Diseases
Identification and biochemical characterization of an acid sphingomyelinase-like protein from the bacterial plant pathogen Ralstonia solanacearum that hydrolyzes ATP to AMP but not sphingomyelin to ceramide.
Leptospirosis
Cytotoxicity of the 42 kDa SMase C sphingomyelinase secreted by Leptospira interrogans serovar Pomona on Vero cells.
Leptospirosis
Evaluation of the Expression and Protective Potential of Leptospiral Sphingomyelinases.
Leukemia
Aggregation of IgE receptors induces degranulation in rat basophilic leukemia cells permeabilized with alpha-toxin from Staphylococcus aureus.
Leukemia
Analysis of receptor-G protein interactions in permeabilized cells.
Leukemia
Apoptotic effects of selected strains of lactic acid bacteria on a human T leukemia cell line are associated with bacterial arginine deiminase and/or sphingomyelinase activities.
Leukemia
ATP-dependent activation of phospholipase C by antigen, NECA, Na3VO4, and GTP-gamma-S in permeabilized RBL cell ghosts: differential augmentation by ATP, phosphoenolpyruvate and phosphocreatine.
Leukemia
Ceramide 1-phosphate, a novel phospholipid in human leukemia (HL-60) cells. Synthesis via ceramide from sphingomyelin.
Leukemia
Ceramide generation during curcumin-induced apoptosis is controlled by crosstalk among Bcl-2, Bcl-xL, caspases and glutathione.
Leukemia
Fc epsilon RI-stimulated Ca(2+)-dependent secretion from rat basophilic leukemia (RBL-2H3) cells permeabilized with Staphylococcal alpha-toxin: Fc epsilon RI-operated signals are not mimicked by the actions of GTP gamma S.
Leukemia
Glutathione regulation of neutral sphingomyelinase in tumor necrosis factor-alpha-induced cell death.
Leukemia
Hexadecylphosphocholine does not influence phospholipase D and sphingomyelinase activity in human leukemia cells.
Leukemia
Holotoxin A? Induces Apoptosis by Activating Acid Sphingomyelinase and Neutral Sphingomyelinase in K562 and Human Primary Leukemia Cells.
Leukemia
Implications of sphingosine kinase 1 expression level for the cellular sphingolipid rheostat: relevance as a marker for daunorubicin sensitivity of leukemia cells.
Leukemia
Malignant fibrous histiocytoma-pleomorphic sarcoma, NOS gene expression, histology, and clinical course. A pilot study.
Leukemia
Mutations in the neutral sphingomyelinase gene SMPD3 implicate the ceramide pathway in human leukemias.
Leukemia
Resveratrol-induced transcriptional up-regulation of ASMase (SMPD1) of human leukemia and cancer cells.
Leukemia
Role of c-jun expression increased by heat shock- and ceramide-activated caspase-3 in HL-60 cell apoptosis. Possible involvement of ceramide in heat shock-induced apoptosis.
Leukemia
Role of sphingomyelin-MAPKs pathway in heat-induced apoptosis.
Leukemia
Stimulation of CD95-induced apoptosis in T-cells by a subtype specific neutral sphingomyelinase inhibitor.
Leukemia
Transbilayer movement of ceramide in the plasma membrane of live cells.
Leukemia
Up-regulation of acid sphingomyelinase during retinoic acid-induced myeloid differentiation of NB4, a human acute promyelocytic leukemia cell line.
Leukemia
Withanolide D induces apoptosis in leukemia by targeting the activation of neutral sphingomyelinase-ceramide cascade mediated by synergistic activation of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase.
Leukemia, Lymphoid
Mutations in the neutral sphingomyelinase gene SMPD3 implicate the ceramide pathway in human leukemias.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Green tea polyphenol epigallocatechin-O-gallate induces cell death by acid sphingomyelinase activation in chronic myeloid leukemia cells.
Leukemia, Myeloid
Positive feedback control of neutral sphingomyelinase activity by ceramide.
Leukemia, Myeloid
Role of ceramide as a lipid mediator of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation.
Leukemia, Myeloid
The phosphoinositide 3-kinase/Akt pathway is activated by daunorubicin in human acute myeloid leukemia cell lines.
Leukemia, Myeloid, Acute
Mutations in the neutral sphingomyelinase gene SMPD3 implicate the ceramide pathway in human leukemias.
Leukemia, Myeloid, Acute
SMPDL3B Predicts Poor Prognosis and Contributes to Development of Acute Myeloid Leukemia.
Leukemia, Promyelocytic, Acute
Up-regulation of acid sphingomyelinase during retinoic acid-induced myeloid differentiation of NB4, a human acute promyelocytic leukemia cell line.
Leukocytosis
Inhibition of normal granulopoiesis by cytostatic agents.
Leukostasis
Cross-complementation of Clostridium perfringens PLC and Clostridium septicum alpha-toxin mutants reveals PLC is sufficient to mediate gas gangrene.
Leukostasis
Use of genetically manipulated strains of Clostridium perfringens reveals that both alpha-toxin and theta-toxin are required for vascular leukostasis to occur in experimental gas gangrene.
Lipidoses
Adult sphingomyelinase deficiency: report of 2 patients who initially presented with psychiatric disorders.
Lipidoses
Calmodulin antagonists chlorpromazine and W-7 inhibit exogenous cholesterol esterification and sphingomyelinase activity in human skin fibroblast cultures. Similarities between drug-induced and Niemann-Pick type C lipidoses.
Lipidoses
Cocaine induces a mixed lysosomal lipidosis in cultured fibroblasts, by inactivation of acid sphingomyelinase and inhibition of phospholipase A1.
Lipidoses
Deficiency of phospholipase C acting on phosphatidylglycerol in Niemann-Pick disease.
Lipidoses
Deficiency of taurocholate-dependent phospholipase C acting on phosphatidylcholine in Niemann-Pick disease.
Lipidoses
Enhancement of ricin A chain immunotoxin activity by perhexiline on established and fresh leukemic cells.
Lipidoses
In vitro and in vivo enhancement of ricin-A chain immunotoxin activity by novel indolizine calcium channel blockers: delayed intracellular degradation linked to lipidosis induction.
Lipidoses
Niemann-Pick disease and juvenile xanthogranuloma. Are they related?
Lipidoses
Partial sphingomyelinase deficiency with sea-blue histiocytosis and neurovisceral dysfunction.
Lipidoses
Reduction of acid sphingomyelinase activity in human fibroblasts induced by AY-9944 and other cationic amphiphilic drugs.
Lipidoses
[Lipidosis with vertical gaze palsy, macular degeneration, and sphingomyelinase deficiency]
Lipidoses
[Niemann-Pick disease type C (subacute neurovisceral lipidosis). Problems of altered sphingomyelinase activity in the brain (author's transl)]
Liver Cirrhosis
Acidic sphingomyelinase controls hepatic stellate cell activation and in vivo liver fibrogenesis.
Liver Cirrhosis
Cathepsin B overexpression due to acid sphingomyelinase ablation promotes liver fibrosis in Niemann-Pick disease.
Liver Cirrhosis
[Expression of ASMase in alcoholic liver fibrosis in rats].
Liver Diseases
Acid Sphingomyelinase Inhibition Prevents Development of Sepsis Sequelae in the Murine Liver.
Liver Diseases
Acidic sphingomyelinase downregulates the liver-specific methionine adenosyltransferase 1A, contributing to tumor necrosis factor-induced lethal hepatitis.
Liver Diseases
Alcoholic and non-alcoholic fatty liver disease: Focus on ceramide.
Liver Diseases
Cathepsin B overexpression due to acid sphingomyelinase ablation promotes liver fibrosis in Niemann-Pick disease.
Liver Diseases
Metabolic therapy: lessons from liver diseases.
Liver Diseases
Serum acid sphingomyelinase is upregulated in chronic hepatitis C infection and non alcoholic fatty liver disease.
Liver Diseases
Sphingomyelinases and Liver Diseases.
Liver Diseases, Alcoholic
Alcoholic liver disease: ASMase implicated in alcoholic liver disease.
Liver Diseases, Alcoholic
Mitochondrial cholesterol accumulation in alcoholic liver disease: Role of ASMase and endoplasmic reticulum stress.
Liver Failure
Acidic sphingomyelinase downregulates the liver-specific methionine adenosyltransferase 1A, contributing to tumor necrosis factor-induced lethal hepatitis.
Liver Failure
Group B streptococcal beta-hemolysin induces mortality and liver injury in experimental sepsis.
Liver Neoplasms
Acid sphingomyelinase is induced by butyrate but does not initiate the anticancer effect of butyrate in HT29 and HepG2 cells.
Liver Neoplasms
Recombinant human acid sphingomyelinase as an adjuvant to sorafenib treatment of experimental liver cancer.
Lung Diseases
Abnormal methylation of seven genes and their associations with clinical characteristics in early stage non-small cell lung cancer.
Lung Diseases
Development of carbohydrate-derived inhibitors of acid sphingomyelinase.
Lung Diseases
Inositol-trisphosphate reduces alveolar apoptosis and pulmonary edema in neonatal lung injury.
Lung Diseases
Quantitative Systems Pharmacology Modeling of Acid Sphingomyelinase Deficiency and the Enzyme Replacement Therapy Olipudase Alfa Is an Innovative Tool for Linking Pathophysiology and Pharmacology.
Lung Diseases
[Dynamics of the indices of natural resistance and of the response to staphylococcal alpha-toxin in acute suppurative lung diseases]
Lung Diseases, Interstitial
Bilateral Cystic Bronchiectasis as Novel Phenotype of Niemann-Pick Disease Type B Successfully Treated With Double Lung Transplantation.
Lung Diseases, Interstitial
Combined Emphysema and Interstitial Lung Disease as a Rare Presentation of Pulmonary Involvement in a Patient with Chronic Visceral Acid Sphingomyelinase Deficiency (Niemann-Pick Disease Type B).
Lung Diseases, Interstitial
Interstitial lung disease in lysosomal storage disorders.
Lung Injury
Acid Sphingomyelinase Inhibition Attenuates Cell Death in Mechanically-Ventilated Newborn Rat Lung.
Lung Injury
Acid sphingomyelinase mediates murine acute lung injury following transfusion of aged platelets.
Lung Injury
Extracellular Sphingomyelinase Rv0888 of Mycobacterium tuberculosis Contributes to Pathological Lung Injury of Mycobacterium smegmatis in Mice via Inducing Formation of Neutrophil Extracellular Traps.
Lung Injury
Inhibition of Neutrophil Apoptosis via Sphingolipid Signaling in Acute Lung Injury.
Lung Injury
Neutral Sphingomyelinase 2: A Novel Target in Cigarette Smoke-induced Apoptosis and Lung Injury.
Lung Injury
nSMase2 activation and trafficking are modulated by oxidative stress to induce apoptosis.
Lung Injury
Reevaluation of Lung Injury in TNF-Induced Shock: The Role of the Acid Sphingomyelinase.
Lung Injury
Role of eicosanoids in staphylococcal alpha-toxin-induced lung injury in the rat.
Lung Injury
Src Regulates Cigarette Smoke-induced Ceramide Generation via nSMase2 in the Airway Epithelium.
Lung Injury
Staphylococcus aureus beta-toxin induces lung injury through syndecan-1.
Lung Injury
The role of group B streptococci beta-hemolysin expression in newborn lung injury.
Lung Neoplasms
Abnormal methylation of seven genes and their associations with clinical characteristics in early stage non-small cell lung cancer.
Lung Neoplasms
Bilateral synchronous multiple lung nodules: Surgical experience from two cases.
Lung Neoplasms
Ceramide mediates nanovesicle shedding and cell death in response to phosphatidylinositol ether lipid analogs and perifosine.
Lung Neoplasms
Characteristics and prognosis of synchronous multiple primary lung cancer after surgical treatment: A systematic review and meta-analysis of current evidence.
Lung Neoplasms
Characterizing the sphingomyelinase pathway triggered by PRIMA-1 derivatives in lung cancer cells with differing p53 status.
Lung Neoplasms
Early clinical diagnosis of synchronous multiple primary lung cancer.
Lung Neoplasms
Lung cancer and lung injury: the dual role of ceramide.
Lung Neoplasms
Neutral sphingomyelinase-2, acid sphingomyelinase, and ceramide levels in COPD patients compared to controls.
Lung Neoplasms
Novel quinuclidinone derivatives induce apoptosis in lung cancer via sphingomyelinase pathways.
Lung Neoplasms
Preoperative virtual simulation for synchronous multiple primary lung cancers using three-dimensional computed tomography lung reconstruction: a case report.
Lung Neoplasms
Single-staged uniportal VATS major pulmonary resection for bilateral synchronous multiple primary lung cancers.
Lung Neoplasms
Surgical Prognosis of Synchronous Multiple Primary Lung Cancer: Systematic Review and Meta-Analysis.
Lung Neoplasms
Surgical Results of Synchronous Multiple Primary Lung Cancers: Similar to the Stage-Matched Solitary Primary Lung Cancers?
Lung Neoplasms
Surgical treatment of synchronous multiple primary lung cancers: a retrospective analysis of 122 patients.
Lung Neoplasms
Synchronous Bilateral Lung Cancer With Discordant Histology.
Lung Neoplasms
Unexpected encounters: high prevalence of synchronous primary lung cancers in a tertiary academic center.
Lung Neoplasms
Uniportal video-assisted thoracoscopic S8 segmentectomy and S1a subsegmentectomy for synchronous multiple primary lung cancers.
Lung Neoplasms
[Analysis on the Prognostic and Survival Factors of Synchronous Multiple Primary Lung Cancer].
Lymphadenopathy
Subclinical course of adult visceral Niemann-Pick type C1 disease. A rare or underdiagnosed disorder?
Lymphatic Metastasis
Surgical Prognosis of Synchronous Multiple Primary Lung Cancer: Systematic Review and Meta-Analysis.
Lymphocytic Choriomeningitis
Acid sphingomyelinase is a key regulator of cytotoxic granule secretion by primary T lymphocytes.
Lymphocytic Choriomeningitis
Fusogenicity of membranes: the impact of acid sphingomyelinase on innate immune responses.
Lymphohistiocytosis, Hemophagocytic
Elevated sphingomyelinase and hypercytokinemia in hemophagocytic lymphohistiocytosis.
Lymphohistiocytosis, Hemophagocytic
Evaluation of the role of secretory sphingomyelinase and bioactive sphingolipids as biomarkers in hemophagocytic lymphohistiocytosis.
Lymphoma
Lysosomal ceramide generated by acid sphingomyelinase triggers cytosolic cathepsin B-mediated degradation of X-linked inhibitor of apoptosis protein in natural killer/T lymphoma cell apoptosis.
Lymphoma
Regulatory roles of cell surface sialylation in susceptibility to sphingomyelinase in human diffuse large B cell lymphoma.
Lymphoma, B-Cell
Regulatory roles of cell surface sialylation in susceptibility to sphingomyelinase in human diffuse large B cell lymphoma.
Lymphoma, Large B-Cell, Diffuse
Regulatory roles of cell surface sialylation in susceptibility to sphingomyelinase in human diffuse large B cell lymphoma.
Lymphoma, T-Cell
Stimulation of CD95-induced apoptosis in T-cells by a subtype specific neutral sphingomyelinase inhibitor.
Lymphoma, T-Cell, Cutaneous
Staphylococcal alpha-toxin tilts the balance between malignant and non-malignant CD4+ T cells in cutaneous T-cell lymphoma.
Lymphoma, T-Cell, Cutaneous
Staphylococcus aureus alpha-toxin inhibits CD8+ T cell-mediated killing of cancer cells in cutaneous T-cell lymphoma.
Lysosomal Storage Diseases
An induced pluripotent stem cell line (TRNDi009-C) from a Niemann-Pick disease type A patient carrying a heterozygous p.L302P (c.905 T>C) mutation in the SMPD1 gene.
Lysosomal Storage Diseases
Autopsy pathology of infantile neurovisceral ASMD (Niemann-Pick Disease type A): Clinicopathologic correlations of a case report.
Lysosomal Storage Diseases
Burden of Illness in Acid Sphingomyelinase Deficiency: A Retrospective Chart Review of 100 Patients.
Lysosomal Storage Diseases
Cathepsin B overexpression due to acid sphingomyelinase ablation promotes liver fibrosis in Niemann-Pick disease.
Lysosomal Storage Diseases
Cholesterol trapping in Niemann-Pick disease type B fibroblasts can be relieved by expressing the phosphotyrosine binding domain of GULP.
Lysosomal Storage Diseases
Clathrin-mediated endocytosis is impaired in type A-B Niemann-Pick disease model cells and can be restored by ICAM-1-mediated enzyme replacement.
Lysosomal Storage Diseases
Consensus recommendation for a diagnostic guideline for acid sphingomyelinase deficiency.
Lysosomal Storage Diseases
Control of endothelial targeting and intracellular delivery of therapeutic enzymes by modulating the size and shape of ICAM-1-targeted carriers.
Lysosomal Storage Diseases
Defective Autophagy, Mitochondrial Clearance and Lipophagy in Niemann-Pick Type B Lymphocytes.
Lysosomal Storage Diseases
Disease manifestations and burden of illness in patients with acid sphingomyelinase deficiency (ASMD).
Lysosomal Storage Diseases
Functional characterization of novel variants in SMPD1 in Indian patients with acid sphingomyelinase deficiency.
Lysosomal Storage Diseases
Generation of an induced pluripotent stem cell line (TRNDi004-I) from a Niemann-Pick disease type B patient carrying a heterozygous mutation of p.L43_A44delLA in the SMPD1 gene.
Lysosomal Storage Diseases
Induced Pluripotent Stem Cells for Disease Modeling and Evaluation of Therapeutics for Niemann-Pick Disease Type A.
Lysosomal Storage Diseases
Lack of Acid Sphingomyelinase Induces Age-Related Retinal Degeneration.
Lysosomal Storage Diseases
Merits of Combination Cortical, Subcortical, and Cerebellar Injections for the Treatment of Niemann-Pick Disease Type A.
Lysosomal Storage Diseases
Mitochondrial biogenesis is transcriptionally repressed in lysosomal lipid storage diseases.
Lysosomal Storage Diseases
Ophthalmologic manifestations of type B Niemann-Pick diseases.
Lysosomal Storage Diseases
Polyneuropathy in feline Niemann-Pick disease.
Lysosomal Storage Diseases
Rapid screening for lipid storage disorders using biochemical markers. Expert center data and review of the literature.
Lysosomal Storage Diseases
Recommendations for clinical monitoring of patients with acid sphingomyelinase deficiency (ASMD).
Lysosomal Storage Diseases
Sphingomyelin lipidosis (Niemann-Pick disease) in a juvenile raccoon (Procyon lotor).
Lysosomal Storage Diseases
The contribution of Niemann-Pick SMPD1 mutations to Parkinson disease in Ashkenazi Jews.
Lysosomal Storage Diseases
[Mutation del 1,02kb in the CLN3 gene and extrapyramidal syndrome].
Macular Degeneration
Cholesterol-mediated activation of acid sphingomyelinase disrupts autophagy in the retinal pigment epithelium.
Macular Degeneration
Protective responses to sublytic complement in the retinal pigment epithelium.
Macular Degeneration
[Lipidosis with vertical gaze palsy, macular degeneration, and sphingomyelinase deficiency]
Magnesium Deficiency
Short-term magnesium deficiency downregulates telomerase, upregulates neutral sphingomyelinase and induces oxidative DNA damage in cardiovascular tissues: relevance to atherogenesis, cardiovascular diseases and aging.
Malaria
Influence of amitriptyline on eryptosis, parasitemia and survival of Plasmodium berghei-infected mice.
Malaria
Neutral sphingomyelinase activity dependent on Mg2+ and anionic phospholipids in the intraerythrocytic malaria parasite Plasmodium falciparum.
Malaria
Phospholipid organization in monkey erythrocytes upon Plasmodium knowlesi infection.
Mastitis
Conversion of chronic staphylococcal mastitis to acute gangrenous mastitis after neutropenia in blood and bone marrow produced by an equine anti-bovine leukocyte serum.
Mastitis
Effect immunization with highly purified alpha- and beta-toxins on staphylococcal mastitis in rabbits.
Mastitis
Geographical variation in the presence of genes encoding superantigenic exotoxins and beta-hemolysin among Staphylococcus aureus isolated from bovine mastitis in Europe and USA.
Mastitis
Identification of nonlipophilic corynebacteria isolated from dairy cows with mastitis.
Mastitis
Immunogenicity of alpha-toxin, capsular polysaccharide (CPS) and recombinant fibronectin-binding protein (r-FnBP) of Staphylococcus aureus in rabbit.
Measles
Ebolavirus requires acid sphingomyelinase activity and plasma membrane sphingomyelin for infection.
Measles
Neutral sphingomyelinase in physiological and measles virus induced T cell suppression.
Medulloblastoma
Off-target function of the Sonic hedgehog inhibitor cyclopamine in mediating apoptosis via nitric oxide-dependent neutral sphingomyelinase 2/ceramide induction.
Melanoma
A novel visible range FRET probe for monitoring acid sphingomyelinase activity in living cells.
Melanoma
Acid sphingomyelinase determines melanoma progression and metastatic behaviour via the microphtalmia-associated transcription factor signalling pathway.
Melanoma
Acid Sphingomyelinase Downregulation Enhances Mitochondrial Fusion and Promotes Oxidative Metabolism in a Mouse Model of Melanoma.
Melanoma
Acidic extracellular pH increases calcium influx-triggered phospholipase D activity along with acidic sphingomyelinase activation to induce matrix metalloproteinase-9 expression in mouse metastatic melanoma.
Melanoma
BETA-GALACTOSYLCERAMIDASE PROMOTES MELANOMA GROWTH VIA MODULATION OF CERAMIDE METABOLISM.
Melanoma
Essential role for acid sphingomyelinase-inhibited autophagy in melanoma response to cisplatin.
Melanoma
Melanogenesis in murine B16 cells exposed to Aeromonas hydrophila cytotoxic enterotoxin.
Melanoma
Melanoma cell metastasis via P-selectin-mediated activation of acid sphingomyelinase in platelets.
Melanoma
Modulation of Acid Sphingomyelinase in Melanoma Reprogrammes the Tumour Immune Microenvironment.
Melanoma
Neutral Sphingomyelinase 2 Heightens Anti-Melanoma Immune Responses and Anti-PD-1 Therapy Efficacy.
Melanoma
Nitric oxide boosts chemoimmunotherapy via inhibition of acid sphingomyelinase in a mouse model of melanoma.
Melanoma
Purification, molecular cloning, and application of a novel sphingomyelin-binding protein (clamlysin) from the brackishwater clam, Corbicula japonica.
Melanoma
Regulation of hematogenous tumor metastasis by acid sphingomyelinase.
Melanoma
Regulation of UDP-glucose:ceramide glucosyltransferase-1 by ceramide.
Melanoma
Role of Acid Sphingomyelinase-Induced Signaling in Melanoma Cells for Hematogenous Tumor Metastasis.
Melanoma
Tumor response to radiotherapy regulated by endothelial cell apoptosis.
Melanoma, Experimental
Acidic extracellular pH increases calcium influx-triggered phospholipase D activity along with acidic sphingomyelinase activation to induce matrix metalloproteinase-9 expression in mouse metastatic melanoma.
Melanoma, Experimental
Host acid sphingomyelinase regulates microvascular function not tumor immunity.
Melanoma, Experimental
Regulation of intracellular ceramide content in B16 melanoma cells. Biological implications of ceramide glycosylation.
Memory Disorders
Pharmacological reversion of sphingomyelin-induced dendritic spine anomalies in a Niemann Pick disease type A mouse model.
Memory Disorders
The Fountain of Youth: It's All in Our Veins.
Meningioma
Phospholipids and acidic sphingomyelinase in human meningiomas.
Mesothelioma
alpha-Toxin of Staphylococcus aureus overcomes acquired cisplatin-resistance in malignant mesothelioma cells.
Mesothelioma, Malignant
alpha-Toxin of Staphylococcus aureus overcomes acquired cisplatin-resistance in malignant mesothelioma cells.
Metabolic Diseases
Acid Sphingomyelinase Down-regulation Alleviates Vascular Endothelial Insulin Resistance in Diabetic Rats.
Metabolic Diseases
[Study of thesaurismosis induced by perhexiline maleate. Confirmation of experimental data]
Microcephaly
Exosomes mediate Zika virus transmission through SMPD3 neutral Sphingomyelinase in cortical neurons.
Microcephaly
Loss of SMPD4 Causes a Developmental Disorder Characterized by Microcephaly and Congenital Arthrogryposis.
Mucocutaneous Lymph Node Syndrome
Elevation of Serum Acid Sphingomyelinase Activity in Acute Kawasaki Disease.
Mucolipidoses
Biosynthesis of sphingomyelinase in normal and Niemann-Pick fibroblasts.
Mucolipidoses
Processing of human acid sphingomyelinase in normal and I-cell fibroblasts.
Mucolipidoses
The p.L302P mutation in the lysosomal enzyme gene SMPD1 is a risk factor for Parkinson disease.
Mucopolysaccharidoses
Ito cells in lysosomal storage disorders. An ultrastructural study.
Multiple Myeloma
Decreased Activity of Blood Acid Sphingomyelinase in the Course of Multiple Myeloma.
Multiple Myeloma
Green tea polyphenol EGCG induces lipid raft clustering and apoptotic cell death by activating protein kinase C? and acid sphingomyelinase through 67-kDa laminin receptor in multiple myeloma cells.
Multiple Myeloma
The Transfer of Sphingomyelinase Contributes to Drug Resistance in Multiple Myeloma.
Multiple Sclerosis
A Robust Liposomal Platform for Direct Colorimetric Detection of Sphingomyelinase Enzyme and Inhibitors.
Multiple Sclerosis
Acid sphingomyelinase deficiency enhances myelin repair after acute and chronic demyelination.
Multiple Sclerosis
Acid sphingomyelinase: No potential as a biomarker for multiple sclerosis.
Multiple Sclerosis
Cambinol, a novel inhibitor of neutral sphingomyelinase 2 shows neuroprotective properties.
Multiple Sclerosis
Cytokines Stimulate the Release of Microvesicles from Myeloid Cells Independently from the P2X7 Receptor/Acid Sphingomyelinase Pathway.
Multiple Sclerosis
Disruption of myelin sheaths in mouse brain in vitro and in vivo by staphylococcal alpha-toxin.
Multiple Sclerosis
Gilenya (FTY720) inhibits acid sphingomyelinase by a mechanism similar to tricyclic antidepressants.
Multiple Sclerosis
Oxidative stress kills human primary oligodendrocytes via neutral sphingomyelinase: implications for multiple sclerosis.
Multiple Sclerosis
Pharmacological Inhibition of Acid Sphingomyelinase Ameliorates Experimental Autoimmune Encephalomyelitis.
Mumps
Comparative study of immune status to infectious agents in elderly patients with multiple myeloma, Waldenstrom's macroglobulinemia, and monoclonal gammopathy of undetermined significance.
Muscle Weakness
Diaphragm dysfunction caused by sphingomyelinase requires the p47(phox) subunit of NADPH oxidase.
Muscle Weakness
Neutral sphingomyelinase 2 is required for cytokine-induced skeletal muscle calpain activation.
Muscle Weakness
Sphingomyelinase depresses force and calcium sensitivity of the contractile apparatus in mouse diaphragm muscle fibers.
Muscle Weakness
Sphingomyelinase stimulates oxidant signaling to weaken skeletal muscle and promote fatigue.
Myasthenia Gravis
[Binocular diplopia and ptosis due to snakebite (Agkistrodon blomhoffi "mamushi")--a case report]
Myelodysplastic Syndromes
Implications of sphingosine kinase 1 expression level for the cellular sphingolipid rheostat: relevance as a marker for daunorubicin sensitivity of leukemia cells.
Myocardial Infarction
Role of lipid rafts in ceramide and nitric oxide signaling in the ischemic and preconditioned hearts.
Myocardial Infarction
Small hairpin RNA and pharmacological targeting of neutral sphingomyelinase prevents diaphragm weakness in rats with heart failure and reduced ejection fraction.
Myositis
Effect of erythromycin on biological activities induced by clostridium perfringens alpha-toxin.
Myotoxicity
Identification of residues critical for toxicity in Clostridium perfringens phospholipase C, the key toxin in gas gangrene.
Nasal Polyps
Cellular responses to Staphylococcus aureus alpha-toxin in chronic rhinosinusitis with nasal polyps.
Nasopharyngeal Carcinoma
Identification of miRNA/mRNA-Negative Regulation Pairs in Nasopharyngeal Carcinoma.
Neoplasm Metastasis
A new twist to the emerging functions of ceramides in cancer: novel role for platelet acid sphingomyelinase in cancer metastasis.
Neoplasm Metastasis
A novel visible range FRET probe for monitoring acid sphingomyelinase activity in living cells.
Neoplasm Metastasis
Diagnosis and treatment of synchronous multiple primary lung cancer - a case report.
Neoplasm Metastasis
Early clinical diagnosis of synchronous multiple primary lung cancer.
Neoplasm Metastasis
Melanoma cell metastasis via P-selectin-mediated activation of acid sphingomyelinase in platelets.
Neoplasm Metastasis
MicroRNAs in Cancer: The 22nd Hiroshima Cancer Seminar/The 4th Japanese Association for RNA Interference Joint International Symposium, 30 August 2012, Grand Prince Hotel Hiroshima.
Neoplasm Metastasis
Neutral sphingomyelinase 2 (nSMase2)-dependent exosomal transfer of angiogenic microRNAs regulate cancer cell metastasis.
Neoplasm Metastasis
Neutral sphingomyelinase and breast cancer research.
Neoplasm Metastasis
Regulation of hematogenous tumor metastasis by acid sphingomyelinase.
Neoplasm Metastasis
Roles and regulation of neutral sphingomyelinase-2 in cellular and pathological processes.
Neoplasm Metastasis
Surgical Prognosis of Synchronous Multiple Primary Lung Cancer: Systematic Review and Meta-Analysis.
Neoplasm Metastasis
Surgical treatment of synchronous multiple primary lung cancers: a retrospective analysis of 122 patients.
Neoplasm Metastasis
[Research Progress in Distinguishing Methods of Simultaneous Multiple Primary Lung Cancer and Intrapulmonary Metastasis].
Neoplasms
"Cross talk" between the bioactive glycerolipids and sphingolipids in signal transduction.
Neoplasms
'Patchiness' and basic cancer research: unravelling the proteases.
Neoplasms
A neutral sphingomyelinase resides in sphingolipid-enriched microdomains and is inhibited by the caveolin-scaffolding domain: potential implications in tumour necrosis factor signalling.
Neoplasms
A new twist to the emerging functions of ceramides in cancer: novel role for platelet acid sphingomyelinase in cancer metastasis.
Neoplasms
A novel cisplatin mediated apoptosis pathway is associated with acid sphingomyelinase and FAS proapoptotic protein activation in ovarian cancer.
Neoplasms
A novel cytoplasmic domain of the p55 tumor necrosis factor receptor initiates the neutral sphingomyelinase pathway.
Neoplasms
A novel pathway for tumor necrosis factor-alpha and ceramide signaling involving sequential activation of tyrosine kinase, p21(ras), and phosphatidylinositol 3-kinase.
Neoplasms
A staphylococcal alpha-toxin fragment. Its characterization and use for mapping biologically-active regions of alpha-toxin.
Neoplasms
Abnormal methylation of seven genes and their associations with clinical characteristics in early stage non-small cell lung cancer.
Neoplasms
Abnormal methylation status of FBXW10 and SMPD3, and associations with clinical characteristics in clear cell renal cell carcinoma.
Neoplasms
Acid ceramidase but not acid sphingomyelinase is required for tumor necrosis factor-{alpha}-induced PGE2 production.
Neoplasms
Acid sphingomyelinase and inhibition by phosphate ion: role of inhibition by phosphatidyl-myo-inositol 3,4,5-triphosphate in oligodendrocyte cell signaling.
Neoplasms
Acid sphingomyelinase determines melanoma progression and metastatic behaviour via the microphtalmia-associated transcription factor signalling pathway.
Neoplasms
Acid sphingomyelinase inhibition suppresses lipopolysaccharide-mediated release of inflammatory cytokines from macrophages and protects against disease pathology in dextran sulphate sodium-induced colitis in mice.
Neoplasms
Acid sphingomyelinase involvement in tumor necrosis factor alpha-regulated vascular and steroid disruption during luteolysis in vivo.
Neoplasms
Acid sphingomyelinase is not essential for the IL-1 and tumor necrosis factor receptor signaling pathway leading to NFkB activation.
Neoplasms
Acid sphingomyelinase is required for cell surface presentation of Met receptor tyrosine kinase in cancer cells.
Neoplasms
Acid sphingomyelinase overexpression enhances the antineoplastic effects of irradiation in vitro and in vivo.
Neoplasms
Acid sphingomyelinase, a novel negative biomarker of ovarian cancer.
Neoplasms
Acidic sphingomyelinase downregulates the liver-specific methionine adenosyltransferase 1A, contributing to tumor necrosis factor-induced lethal hepatitis.
Neoplasms
Activation of endothelial nitric-oxide synthase by tumor necrosis factor-alpha: a novel pathway involving sequential activation of neutral sphingomyelinase, phosphatidylinositol-3' kinase, and Akt.
Neoplasms
Activation of sphingosine kinase by tumor necrosis factor-alpha inhibits apoptosis in human endothelial cells.
Neoplasms
Acute systemic inflammation up-regulates secretory sphingomyelinase in vivo: a possible link between inflammatory cytokines and atherogenesis.
Neoplasms
Adenoviral transduction of human acid sphingomyelinase into neo-angiogenic endothelium radiosensitizes tumor cure.
Neoplasms
Altered adipose and plasma sphingolipid metabolism in obesity: a potential mechanism for cardiovascular and metabolic risk.
Neoplasms
Antiproliferative Effects of Thymoquinone in MCF-7 Breast and HepG2 Liver Cancer Cells: Possible Role of Ceramide and ER Stress.
Neoplasms
Apolipoprotein C-I induces apoptosis in human aortic smooth muscle cells via recruiting neutral sphingomyelinase.
Neoplasms
Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase.
Neoplasms
Biochemical properties of mammalian neutral sphingomyelinase 2 and its role in sphingolipid metabolism.
Neoplasms
Bioinformatic Exploration for Prognostic Significance of Sphingolipid Metabolism-Related Genes in Invasive Ductal Carcinoma Using the Cancer Genome Atlas Cohort.
Neoplasms
Boswellic acid induces epigenetic alterations by modulating DNA methylation in colorectal cancer cells.
Neoplasms
c-Jun is a downstream target for ceramide-activated protein phosphatase in A431 cells.
Neoplasms
Caspase-8 and caspase-7 sequentially mediate proteolytic activation of acid sphingomyelinase in TNF-R1 receptosomes.
Neoplasms
Cathepsin D links TNF-induced acid sphingomyelinase to Bid-mediated caspase-9 and -3 activation.
Neoplasms
Caveolin-1 regulates the ASMase/ceramide-mediated radiation response of endothelial cells in the context of tumor-stroma interactions.
Neoplasms
CD40 signals apoptosis through FAN-regulated activation of the sphingomyelin-ceramide pathway.
Neoplasms
Ceramide accumulation is associated with increased apoptotic cell death in cultured fibroblasts of sphingolipid activator protein-deficient mouse but not in fibroblasts of patients with Farber disease.
Neoplasms
Ceramide and cell death receptor clustering.
Neoplasms
Ceramide and cyclic adenosine monophosphate (cAMP) induce cAMP response element binding protein phosphorylation via distinct signaling pathways while having opposite effects on myeloid cell survival.
Neoplasms
Ceramide generated by acidic sphingomyelinase contributes to tumor necrosis factor-alpha-mediated apoptosis in human colon HT-29 cells through glycosphingolipids formation. Possible role of ganglioside GD3.
Neoplasms
Ceramide plays a prominent role in MDA-7/IL-24-induced cancer-specific apoptosis.
Neoplasms
Ceramide selectively inhibits early events in the response of human neutrophils to tumor necrosis factor.
Neoplasms
Ceramide triggers p53-dependent apoptosis in genetically defined fibrosarcoma tumour cells.
Neoplasms
Ceramide triggers Weibel-Palade body exocytosis.
Neoplasms
Ceramide-induced cell death in malignant cells.
Neoplasms
Ceramide-induced translocation of protein kinase C-delta and -epsilon to the cytosol. Implications in apoptosis.
Neoplasms
Ceramide: an intracellular signal for apoptosis.
Neoplasms
Ceramides that mediate apoptosis reduce glucose uptake and transporter affinity for glucose in human leukaemic cell lines but not in neutrophils.
Neoplasms
Cervicovaginal Inflammatory Cytokines and Sphingomyelinase in Women With and Without Bacterial Vaginosis.
Neoplasms
Characteristics and prognosis of synchronous multiple primary lung cancer after surgical treatment: A systematic review and meta-analysis of current evidence.
Neoplasms
Characterization of the sphingomyelin content of isolated pancreatic islets. Evaluation of the role of sphingomyelin hydrolysis in the action of interleukin-1 to induce islet overproduction of nitric oxide.
Neoplasms
Chemotherapeutic Agents-Induced Ceramide-Rich Platforms (CRPs) in Endothelial Cells and Their Modulation.
Neoplasms
Cholesterol and sphingolipids in alcohol-induced liver injury.
Neoplasms
Chronic Psychosocial Stress in Mice Is Associated With Increased Acid Sphingomyelinase Activity in Liver and Serum and With Hepatic C16:0-Ceramide Accumulation.
Neoplasms
Comparative epigenomics of human and mouse mammary tumors.
Neoplasms
Comparison of CD28-B7.1 and B7.2 functional interaction in resting human T cells: phosphatidylinositol 3-kinase association to CD28 and cytokine production.
Neoplasms
Comprehensive genomic profiling aids in understanding the lesion origins of a patient with six synchronous invasive lung adenocarcinomas: a case study.
Neoplasms
Crystal structure of mammalian acid sphingomyelinase.
Neoplasms
Cytolysis mediated by ionophores and pore-forming agents: role of intracellular calcium in apoptosis.
Neoplasms
De novo ceramide synthesis is responsible for the anti-tumor properties of camptothecin and doxorubicin in follicular thyroid carcinoma.
Neoplasms
Decreasing the apoptotic threshold of tumor cells through protein kinase C inhibition and sphingomyelinase activation increases tumor killing by ionizing radiation.
Neoplasms
Detection of alkaline sphingomyelinase activity in human stool: proposed role as a new diagnostic and prognostic marker of colorectal cancer.
Neoplasms
Diagnosis and treatment of synchronous multiple primary lung cancer - a case report.
Neoplasms
Differential effects of sphingomyelinase and cell-permeable ceramide analogs on proliferation of Swiss 3T3 fibroblasts.
Neoplasms
Differential regulation of microRNA-15a by radiation affects angiogenesis and tumor growth via modulation of acid sphingomyelinase.
Neoplasms
Differential regulation of sphingomyelinase and ceramidase activities by growth factors and cytokines. Implications for cellular proliferation and differentiation.
Neoplasms
Distinct adapter proteins mediate acid versus neutral sphingomyelinase activation through the p55 receptor for tumor necrosis factor.
Neoplasms
Divergent role of ceramide generated by exogenous sphingomyelinases on NF-kappa B activation and apoptosis in human colon HT-29 cells.
Neoplasms
Drugs That Modify Cholesterol Metabolism Alter the p38/JNK-Mediated Targeted and Nontargeted Response to Alpha and Auger Radioimmunotherapy.
Neoplasms
Early clinical diagnosis of synchronous multiple primary lung cancer.
Neoplasms
Early events in the action of staphylococcal alpha-toxin on the plasma membrane of adrenocortical Y1 tumor cells.
Neoplasms
Effect of erythromycin on biological activities induced by clostridium perfringens alpha-toxin.
Neoplasms
Effects of staphylococcus alpha-toxin and streptolysin S on the oxidation of succinate by ascites tumour cells.
Neoplasms
Effects of ursodeoxycholate and other bile salts on levels of rat intestinal alkaline sphingomyelinase: a potential implication in tumorigenesis.
Neoplasms
Elevation of de novo ceramide synthesis in tumor masses and the role of microsomal dihydroceramide synthase.
Neoplasms
Endothelial cell inflammatory responses to tumor necrosis factor alpha. Ceramide-dependent and -independent mitogen-activated protein kinase cascades.
Neoplasms
Endothelial membrane remodeling is obligate for anti-angiogenic radiosensitization during tumor radiosurgery.
Neoplasms
Endothelial nitric oxide synthase activation by tumor necrosis factor alpha through neutral sphingomyelinase 2, sphingosine kinase 1, and sphingosine 1 phosphate receptors: a novel pathway relevant to the pathophysiology of endothelium.
Neoplasms
Enhanced acid sphingomyelinase activity drives immune evasion and tumor growth in non-small cell lung carcinoma.
Neoplasms
Enhancement of Soft Tissue Sarcoma Response to Gemcitabine through Timed Administration of a Short-Acting Anti-Angiogenic Agent.
Neoplasms
Essential role for acid sphingomyelinase-inhibited autophagy in melanoma response to cisplatin.
Neoplasms
Evidence for involvement of mitogen-activated protein kinase, rather than stress-activated protein kinase, in potentiation of 1-beta-D-arabinofuranosylcytosine-induced apoptosis by interruption of protein kinase C signaling.
Neoplasms
Fas-mediated apoptosis and sphingomyelinase signal transduction: the role of ceramide as a second messenger for apoptosis.
Neoplasms
Fatty acid synthase causes drug resistance by inhibiting TNF-? and ceramide production.
Neoplasms
Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling.
Neoplasms
Functional inhibition of acid sphingomyelinase by Fluphenazine triggers hypoxia-specific tumor cell death.
Neoplasms
Gentamicin Targets Acid Sphingomyelinase in Cancer: The Case of the Human Gastric Cancer NCI-N87 Cells.
Neoplasms
Glutathione regulation of neutral sphingomyelinase in tumor necrosis factor-alpha-induced cell death.
Neoplasms
Gynaecologic concerns for young women exposed to gonadotoxic chemotherapy.
Neoplasms
Heat shock protein 70.1 (Hsp70.1) affects neuronal cell fate by regulating lysosomal acid sphingomyelinase.
Neoplasms
HER2-positive breast cancer that resists therapeutic drugs and ionizing radiation releases sphingomyelin-based molecules to circulating blood serum.
Neoplasms
High precision multi-genome scale reannotation of enzyme function by EFICAz.
Neoplasms
Host acid sphingomyelinase regulates microvascular function not tumor immunity.
Neoplasms
Human adipocyte differentiation and composition of disease-relevant lipids are regulated by miR-221-3p.
Neoplasms
Human alkaline ceramidase 2 promotes the growth, invasion, and migration of hepatocellular carcinoma cells via sphingomyelin phosphodiesterase acid-like 3B.
Neoplasms
Human hyperimmune globulin protects against the cytotoxic action of staphylococcal alpha-toxin in vitro and in vivo.
Neoplasms
Identification and biochemical characterization of an acid sphingomyelinase-like protein from the bacterial plant pathogen Ralstonia solanacearum that hydrolyzes ATP to AMP but not sphingomyelin to ceramide.
Neoplasms
Identification of aberrant forms of alkaline sphingomyelinase (NPP7) associated with human liver tumorigenesis.
Neoplasms
Impaired cutaneous permeability barrier function, skin hydration, and sphingomyelinase activity in keratin 10 deficient mice.
Neoplasms
Impaired neutral sphingomyelinase activation and cutaneous barrier repair in FAN-deficient mice.
Neoplasms
Increased liver tumor formation in neutral sphingomyelinase-2 deficient mice.
Neoplasms
Increased steroid hormone secretion in mouse Leydig tumor cells after induction of cholesterol translocation by sphingomyelin degradation.
Neoplasms
Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway.
Neoplasms
Induction of stress-activated protein kinases/c-Jun N-terminal kinases by the p55 tumour necrosis factor receptor does not require sphingomyelinases.
Neoplasms
Induction of tissue factor production but not the upregulation of adhesion molecule expression by ceramide in human vascular endothelial cells.
Neoplasms
Influence of Bax or Bcl-2 overexpression on the ceramide-dependent apoptotic pathway in glioma cells.
Neoplasms
Inhibition of endothelial interleukin-8 production and neutrophil transmigration by Staphylococcus aureus beta-hemolysin.
Neoplasms
Inhibition of neutral sphingomyelinase 2 promotes remyelination.
Neoplasms
Inhibition of tumor necrosis factor-induced cell death in MCF7 by a novel inhibitor of neutral sphingomyelinase.
Neoplasms
Interferons increase cell resistance to Staphylococcal alpha-toxin.
Neoplasms
Interleukin-4 suppresses the enhancement of ceramide synthesis and cutaneous permeability barrier functions induced by tumor necrosis factor-alpha and interferon-gamma in human epidermis.
Neoplasms
Involvement of Fas receptor and not tumor necrosis factor-alpha receptor in ultraviolet-induced activation of acid sphingomyelinase.
Neoplasms
Ionizing radiations increase the activity of the cell surface glycohydrolases and the plasma membrane ceramide content.
Neoplasms
It Takes a CAD to Kill a Tumor Cell with a LMP.
Neoplasms
Kit signaling and negative regulation of daunorubicin-induced apoptosis: role of phospholipase Cgamma.
Neoplasms
Management for Residual Ground-Glass Opacity Lesions After Resection of Main Tumor in Multifocal Lung Cancer: A Case Report and Literature Review.
Neoplasms
Measurement of ceramide and sphingolipid metabolism in tumors: potential modulation of chemotherapy.
Neoplasms
Membrane rafts-redox signalling pathway contributes to renal fibrosis via modulation of the renal tubular epithelial-mesenchymal transition.
Neoplasms
Metabolic profiling-based data-mining for an effective chemical combination to induce apoptosis of cancer cells.
Neoplasms
MicroRNAs in Cancer: The 22nd Hiroshima Cancer Seminar/The 4th Japanese Association for RNA Interference Joint International Symposium, 30 August 2012, Grand Prince Hotel Hiroshima.
Neoplasms
Modification of LDL with human secretory phospholipase A(2) or sphingomyelinase promotes its arachidonic acid-releasing propensity.
Neoplasms
Modulation of Acid Sphingomyelinase in Melanoma Reprogrammes the Tumour Immune Microenvironment.
Neoplasms
Modulation of CYP3A4 expression by ceramide in human colon carcinoma HT-29 cells.
Neoplasms
Molecular cloning, characterization, and expression of a novel human neutral sphingomyelinase.
Neoplasms
Molecular modeling of human neutral sphingomyelinase provides insight into its molecular interactions.
Neoplasms
Mutations in the neutral sphingomyelinase gene SMPD3 implicate the ceramide pathway in human leukemias.
Neoplasms
Myelin contains neutral sphingomyelinase activity that is stimulated by tumor necrosis factor-alpha.
Neoplasms
Neutral sphingomyelinase 2 (nSMase2)-dependent exosomal transfer of angiogenic microRNAs regulate cancer cell metastasis.
Neoplasms
Neutral Sphingomyelinase 2 Heightens Anti-Melanoma Immune Responses and Anti-PD-1 Therapy Efficacy.
Neoplasms
Neutral sphingomyelinase 2 inhibitors based on the 4-(1H-imidazol-2-yl)-2,6-dialkoxyphenol scaffold.
Neoplasms
Neutral sphingomyelinase 2 modulates cytotoxic effects of protopanaxadiol on different human cancer cells.
Neoplasms
Neutral sphingomyelinase action stimulates signal transduction of tumor necrosis factor-alpha in the synthesis of cholesteryl esters in human fibroblasts.
Neoplasms
Neutral sphingomyelinase activation precedes NADPH oxidase-dependent damage in neurons exposed to the proinflammatory cytokine tumor necrosis factor-?.
Neoplasms
Neutral sphingomyelinase and breast cancer research.
Neoplasms
Neutral Sphingomyelinase-2 (nSMase2) is the Primary Neutral Sphingomyelinase Isoform Activated by Tumor Necrosis Factor-? in MCF-7 cells.
Neoplasms
Neutral sphingomyelinase-3 is a DNA damage and nongenotoxic stress-regulated gene that is deregulated in human malignancies.
Neoplasms
Neutral sphingomyelinase: past, present and future.
Neoplasms
Neutral Sphingomyelinases in Cancer: Friend or Foe?
Neoplasms
Next Generation Sequencing Reveals a Synchronous Trilateral Lung Adenocarcinoma Case with Distinct Driver Alterations of EGFR 19 Deletion or EGFR 20 Insertion or EZR-ROS1 Fusion.
Neoplasms
Nitric Oxide Generated by Tumor-Associated Macrophages Is Responsible for Cancer Resistance to Cisplatin and Correlated With Syntaxin 4 and Acid Sphingomyelinase Inhibition.
Neoplasms
Nitric oxide mediates natural polyphenol-induced Bcl-2 down-regulation and activation of cell death in metastatic B16 melanoma.
Neoplasms
Novel tumor necrosis factor-responsive mammalian neutral sphingomyelinase-3 is a C-tail-anchored protein.
Neoplasms
Off-target function of the Sonic hedgehog inhibitor cyclopamine in mediating apoptosis via nitric oxide-dependent neutral sphingomyelinase 2/ceramide induction.
Neoplasms
Oligomerization of 3H-labelled staphylococcal alpha-toxin and fragments on adrenocortical Y1 tumour cells.
Neoplasms
Omega-3 polyunsaturated fatty acids attenuate breast cancer growth through activation of a neutral sphingomyelinase-mediated pathway.
Neoplasms
Optical and photoacoustic radiofrequency spectroscopic analysis for detecting red blood cell death.
Neoplasms
Outcomes of Spatially Fractionated Radiotherapy (GRID) for Bulky Soft Tissue Sarcomas in a Large Animal Model.
Neoplasms
Palmitate-activated astrocytes via serine palmitoyltransferase increase BACE1 in primary neurons by sphingomyelinases.
Neoplasms
Pathological and Prognostic Indications of the mdig Gene in Human Lung Cancer.
Neoplasms
Pazopanib radio-sensitization of human sarcoma tumors.
Neoplasms
Primary synchronous small and non-small cell lung cancer in the same lung lobe: A case report.
Neoplasms
Purification and characterization of a magnesium-dependent neutral sphingomyelinase from bovine brain.
Neoplasms
Re-configuration of sphingolipid metabolism by oncogenic transformation.
Neoplasms
Red blood cell clearance in inflammation.
Neoplasms
Reduction in alkaline sphingomyelinase in colorectal tumorigenesis is not related to the APC gene mutation.
Neoplasms
Regulated secretion of acid sphingomyelinase: implications for selectivity of ceramide formation.
Neoplasms
Regulation of hematogenous tumor metastasis by acid sphingomyelinase.
Neoplasms
Regulation of neutral sphingomyelinase-2 (nSMase2) by tumor necrosis factor-alpha involves protein kinase C-delta in lung epithelial cells.
Neoplasms
Regulation of sphingomyelinases in cells of the oligodendrocyte lineage.
Neoplasms
Regulatory T cells reduce endothelial neutral sphingomyelinase 2 to prevent T-cell migration into tumors.
Neoplasms
Remodeling of cellular cytoskeleton by the acid sphingomyelinase/ceramide pathway.
Neoplasms
Requirement of FADD for tumor necrosis factor-induced activation of acid sphingomyelinase.
Neoplasms
Resveratrol-induced transcriptional up-regulation of ASMase (SMPD1) of human leukemia and cancer cells.
Neoplasms
Riccardin D-N induces lysosomal membrane permeabilization by inhibiting acid sphingomyelinase and interfering with sphingomyelin metabolism in vivo.
Neoplasms
Role for furin in tumor necrosis factor alpha-induced activation of the matrix metalloproteinase/sphingolipid mitogenic pathway.
Neoplasms
Role for neutral sphingomyelinase-2 in tumor necrosis factor alpha-stimulated expression of vascular cell adhesion molecule-1 (VCAM) and intercellular adhesion molecule-1 (ICAM) in lung epithelial cells: p38 MAPK is an upstream regulator of nSMase2.
Neoplasms
Role of Acid Sphingomyelinase and Ceramide in Mechano-Acoustic Enhancement of Tumor Radiation Responses.
Neoplasms
Role of Acid Sphingomyelinase-Induced Signaling in Melanoma Cells for Hematogenous Tumor Metastasis.
Neoplasms
Role of ceramide/sphingomyelin (SM) balance regulated through "SM cycle" in cancer.
Neoplasms
Role of nuclear factor-kappaB activation in cytokine- and sphingomyelinase-stimulated inducible nitric oxide synthase gene expression in vascular smooth muscle cells.
Neoplasms
Roles and regulation of neutral sphingomyelinase-2 in cellular and pathological processes.
Neoplasms
Roles for tumor necrosis factor receptor p55 and sphingomyelinase in repairing the cutaneous permeability barrier.
Neoplasms
Selected Clinical Features Fail to Predict Inflammatory Gene Expressions for TNF-?, TNFR1, NSMAF, Casp3 and IL-8 in Tendons of Patients with Rotator Cuff Tendinopathy.
Neoplasms
SMPDL3B Predicts Poor Prognosis and Contributes to Development of Acute Myeloid Leukemia.
Neoplasms
Sphingolipid Metabolism in Glioblastoma and Metastatic Brain Tumors: A Review of Sphingomyelinases and Sphingosine-1-Phosphate.
Neoplasms
Sphingolipids in inflammatory hypoxia.
Neoplasms
Sphingomyelin hydrolysis during apoptosis.
Neoplasms
Sphingomyelin metabolism is a regulator of KRAS function.
Neoplasms
Sphingomyelin phosphodiesterase 3 methylation and silencing in oral squamous cell carcinoma results in increased migration and invasion and altered stress response.
Neoplasms
Sphingosine Kinase-1 Protects Multiple Myeloma from Apoptosis Driven by Cancer-Specific Inhibition of RTKs.
Neoplasms
Sphingosine mediates the immediate negative inotropic effects of tumor necrosis factor-alpha in the adult mammalian cardiac myocyte.
Neoplasms
Spinal ceramide modulates the development of morphine antinociceptive tolerance via peroxynitrite-mediated nitroxidative stress and neuroimmune activation.
Neoplasms
Src Mediates Epigallocatechin-3-O-Gallate-Elicited Acid Sphingomyelinase Activation.
Neoplasms
Staphylococcal toxins and protein A differentially induce cytotoxicity and release of tumor necrosis factor-alpha from human keratinocytes.
Neoplasms
Staphylococcus aureus alpha-toxin induces apoptosis in peripheral blood mononuclear cells: role of endogenous tumour necrosis factor-alpha and the mitochondrial death pathway.
Neoplasms
Staphylococcus aureus alpha-toxin inhibits CD8+ T cell-mediated killing of cancer cells in cutaneous T-cell lymphoma.
Neoplasms
Stimulation of the ceramide pathway partially mimics lipopolysaccharide-induced responses in murine peritoneal macrophages.
Neoplasms
Sunitinib and SU11652 Inhibit Acid Sphingomyelinase, Destabilize Lysosomes, and Inhibit Multidrug Resistance.
Neoplasms
Surgical Prognosis of Synchronous Multiple Primary Lung Cancer: Systematic Review and Meta-Analysis.
Neoplasms
Survival and prognostic factors in surgically resected synchronous multiple primary lung cancers.
Neoplasms
SUVmax and Tumor Size Predict Surgical Outcome of Synchronous Multiple Primary Lung Cancers.
Neoplasms
SUVmax Ratio on PET/CT May Differentiate Between Lung Metastases and Synchronous Multiple Primary Lung Cancer.
Neoplasms
Synovial fibroblasts and the sphingomyelinase pathway: sphingomyelin turnover and ceramide generation are not signaling mechanisms for the actions of tumor necrosis factor-alpha.
Neoplasms
Syntaxin 4 is required for acid sphingomyelinase activity and apoptotic function.
Neoplasms
Targeting acid sphingomyelinase with anti-angiogenic chemotherapy.
Neoplasms
The Effects of ASMase Mediated Endothelial Cell Apoptosis in Multiple Hypofractionated Irradiations in CT26 Tumor Bearing Mice.
Neoplasms
The inhibition of lipopolysaccharide-induced tumor necrosis factor-alpha and nitric oxide production by Clostridium perfringens alpha-toxin and its relation to alpha-toxin-induced intracellular ceramide generation.
Neoplasms
The juxtamembrane linker in neutral sphingomyelinase-2 functions as an intramolecular allosteric switch that activates the enzyme.
Neoplasms
The Roles of Neutral Sphingomyelinases in Neurological Pathologies.
Neoplasms
TNF receptor death domain-associated proteins TRADD and FADD signal activation of acid sphingomyelinase.
Neoplasms
TNF-alpha-induced endothelium-independent vasodilation: a role for phospholipase A2-dependent ceramide signaling.
Neoplasms
Toxicity of oxidized phosphatidylcholines in cultured human melanoma cells.
Neoplasms
Transformation-associated changes in sphingolipid metabolism sensitize cells to lysosomal cell death induced by inhibitors of Acid sphingomyelinase.
Neoplasms
Tumor cell resistance to apoptosis due to a defect in the activation of sphingomyelinase and the 24 kDa apoptotic protease (AP24).
Neoplasms
Tumor necrosis factor (TNF)-alpha activates c-raf-1 kinase via the p55 TNF receptor engaging neutral sphingomyelinase.
Neoplasms
Tumor necrosis factor (TNF)-alpha inhibits insulin signaling through stimulation of the p55 TNF receptor and activation of sphingomyelinase.
Neoplasms
Tumor necrosis factor alpha increases neuronal vulnerability to excitotoxic necrosis by inducing expression of the AMPA-glutamate receptor subunit GluR1 via an acid sphingomyelinase- and NF-kappaB-dependent mechanism.
Neoplasms
Tumor necrosis factor alpha stimulates sphingomyelinase through the 55 kDa receptor in HL-60 cells.
Neoplasms
Tumor necrosis factor-alpha stimulates the maturation of sterol regulatory element binding protein-1 in human hepatocytes through the action of neutral sphingomyelinase.
Neoplasms
Tumor necrosis factor-alpha, sphingomyelinase and ceramides activate tyrosine kinase, p21Ras and phosphatidylinositol 3-kinase: implications for glucose transport and insulin resistance.
Neoplasms
Tumor necrosis factor-alpha, sphingomyelinase, and ceramide inhibit store-operated calcium entry in thyroid FRTL-5 cells.
Neoplasms
Tumor necrosis factor-alpha-induced neutral sphingomyelinase-2 modulates synaptic plasticity by controlling the membrane insertion of NMDA receptors.
Neoplasms
Tumor response to radiotherapy regulated by endothelial cell apoptosis.
Neoplasms
Unexpected encounters: high prevalence of synchronous primary lung cancers in a tertiary academic center.
Neoplasms
Use of acid sphingomyelinase for cancer therapy.
Neoplasms
[Analysis on the Prognostic and Survival Factors of Synchronous Multiple Primary Lung Cancer].
Neoplasms
[Ceramide: a lipid mediator of apoptotic signal transduction]
Neoplasms
[Changes in sphingomyelinase activity, tumor necrosis factor alpha level, and lipid peroxidation rate in the course of development of cholestatic liver injury]
Neoplasms
[Changes in the activity of neutral and acidic isoforms of sphingomyelinase in hepatoma-22, regenerating and ischemic liver]
Neoplasms
[Concordant point mutation of ETS-related gene (ERG) in tumor tissues from a synchronous multiple primary lung cancer: A case report].
Neoplasms
[Functional state of a sphingomyeline cycle and free radical lipid oxidation activity of a rat's liver during different phases of starvation].
Neoplasms
[Relationship of tumor necrosis factor alpha expression with activation of sphingomyelinase and lipid peroxidation after removal of cholestatic factor]
Neoplasms
[Synchronous Multiple Primary Lung Cancer Dignosed ?by Different Phenotype-genotype: A Case Report and Literature Review].
Neoplasms
[The effect of tumor necrosis factor on the free sphingosine level and sphingomyelinase in murine liver cells and nuclei]
Neoplasms
[TNF-? regulates the proliferation of human breast cancer cells via regulation of ceramide content].
Nephritis
Altered sphingomyelinase and ceramide expression in the setting of ischemic and nephrotoxic acute renal failure.
Nephrotic Syndrome
Podocyte sphingomyelin phosphodiesterase acid-like 3b decreases among children with idiopathic nephrotic syndrome.
Nephrotic Syndrome
Urinary excretion of sphingomyelinase phosphodiesterase acid-like 3b in children with intractable nephrotic syndrome.
Nervous System Diseases
A novel and potent brain penetrant inhibitor of extracellular vesicle release.
Nervous System Diseases
Bilateral Cystic Bronchiectasis as Novel Phenotype of Niemann-Pick Disease Type B Successfully Treated With Double Lung Transplantation.
Nervous System Diseases
Interactions between neural membrane glycerophospholipid and sphingolipid mediators: a recipe for neural cell survival or suicide.
Nervous System Diseases
Neutral sphingomyelinase 2 inhibitors based on the 4-(1H-imidazol-2-yl)-2,6-dialkoxyphenol scaffold.
Nervous System Diseases
The Roles of Neutral Sphingomyelinases in Neurological Pathologies.
Neurilemmoma
The ATP-binding cassette transporter-2 (ABCA2) regulates esterification of plasma membrane cholesterol by modulation of sphingolipid metabolism.
Neuroblastoma
Antidepressant-induced lipidosis with special reference to tricyclic compounds.
Neuroblastoma
Catabolism of exogenous and endogenous sphingomyelin and phosphatidylcholine by homogenates and subcellular fractions of cultured neuroblastoma cells. Effects of anesthetics.
Neuroblastoma
Evidence that neutral sphingomyelinase of cultured murine neuroblastoma cells is oriented externally on the plasma membrane.
Neuroblastoma
Ionizing radiations increase the activity of the cell surface glycohydrolases and the plasma membrane ceramide content.
Neuroblastoma
Localization of neutral magnesium-stimulated sphingomyelinase in plasma membrane of cultured neuroblastoma cells.
Neuroblastoma
Neutral sphingomyelinase activation precedes NADPH oxidase-dependent damage in neurons exposed to the proinflammatory cytokine tumor necrosis factor-?.
Neuroblastoma
Sphingomyelinase metabolites control survival and apoptotic death in SH-SY5Y neuroblastoma cells.
Neuroblastoma
The role of gangliosides in fenretinide-induced apoptosis of neuroblastoma.
Neuroblastoma
Tricyclic antidepressants induce sphingomyelinase deficiency in fibroblast and neuroblastoma cell cultures.
Neurodegenerative Diseases
Acid Sphingomyelinase Inhibition Mitigates Histopathologic and Behavioral Changes in a Murine Model of Traumatic Brain Injury.
Neurodegenerative Diseases
Alterations of myelin-specific proteins and sphingolipids characterize the brains of acid sphingomyelinase-deficient mice, an animal model of Niemann-Pick disease type A.
Neurodegenerative Diseases
Neutral sphingomyelinase increases and delocalizes in the absence of Toll-Like Receptor 4: A new insight for MPTP neurotoxicity.
Neurodegenerative Diseases
Pharmacological inhibition of nSMase2 reduces brain exosome release and ?-synuclein pathology in a Parkinson's disease model.
Neurodegenerative Diseases
Potential therapeutic target for aging and age-related neurodegenerative diseases: the role of acid sphingomyelinase.
Neurodegenerative Diseases
Promising neuroprotective effects of ?-caryophyllene against LPS-induced oligodendrocyte toxicity: A mechanistic study.
Neuroinflammatory Diseases
Acid sphingomyelinase activity triggers microparticle release from glial cells.
Neuroinflammatory Diseases
Inhibition of extracellular vesicle pathway using neutral sphingomyelinase inhibitors as a neuroprotective treatment for brain injury.
Neuroinflammatory Diseases
Neutral Sphingomyelinase Behaviour in Hippocampus Neuroinflammation of MPTP-Induced Mouse Model of Parkinson's Disease and in Embryonic Hippocampal Cells.
Neuroinflammatory Diseases
Neutral Sphingomyelinase Inhibition Alleviates LPS-Induced Microglia Activation and Neuroinflammation after Experimental Traumatic Brain Injury.
Neurologic Manifestations
Exosomes mediate Zika virus transmission through SMPD3 neutral Sphingomyelinase in cortical neurons.
Neuronal Ceroid-Lipofuscinoses
Bi-functional IgG-lysosomal enzyme fusion proteins for brain drug delivery.
Nevus
BETA-GALACTOSYLCERAMIDASE PROMOTES MELANOMA GROWTH VIA MODULATION OF CERAMIDE METABOLISM.
Niemann-Pick Disease, Type A
?-Tocopherol Effect on Endocytosis and Its Combination with Enzyme Replacement Therapy for Lysosomal Disorders: A New Type of Drug Interaction?
Niemann-Pick Disease, Type A
A family with visceral course of Niemann-Pick disease, macular halo syndrome and low sphingomyelin degradation rate.
Niemann-Pick Disease, Type A
A new variant of sphingomyelinase deficiency (Niemann-Pick): visceromegaly, minimal neurological lesions and low in vivo degradation rate of sphingomyelin.
Niemann-Pick Disease, Type A
A novel association between angiokeratoma corporis diffusum and acid sphingomyelinase deficiency.
Niemann-Pick Disease, Type A
AAV8-mediated hepatic expression of acid sphingomyelinase corrects the metabolic defect in the visceral organs of a mouse model of Niemann-Pick disease.
Niemann-Pick Disease, Type A
Acid sphingomyelinase deficiency (Niemann?Pick disease Type B) as an inflammatory disease.
Niemann-Pick Disease, Type A
Acid Sphingomyelinase Deficiency Ameliorates Farber Disease.
Niemann-Pick Disease, Type A
Acid sphingomyelinase deficiency attenuates bleomycin-induced lung inflammation and fibrosis in mice.
Niemann-Pick Disease, Type A
Acid sphingomyelinase deficiency contributes to resistance of scleroderma fibroblasts to Fas-mediated apoptosis.
Niemann-Pick Disease, Type A
Acid sphingomyelinase deficiency does not protect from graft-versus-host disease in transplant recipients with Niemann-Pick disease.
Niemann-Pick Disease, Type A
Acid sphingomyelinase deficiency enhances myelin repair after acute and chronic demyelination.
Niemann-Pick Disease, Type A
Acid sphingomyelinase deficiency exacerbates LPS-induced experimental periodontitis.
Niemann-Pick Disease, Type A
Acid sphingomyelinase deficiency in Beckwith Wiedemann syndrome.
Niemann-Pick Disease, Type A
Acid sphingomyelinase deficiency in Western diet-fed mice protects against adipocyte hypertrophy and diet-induced liver steatosis.
Niemann-Pick Disease, Type A
Acid sphingomyelinase deficiency increases susceptibility to fatal alphavirus encephalomyelitis.
Niemann-Pick Disease, Type A
Acid Sphingomyelinase Deficiency Prevents Diet-induced Hepatic Triacylglycerol Accumulation and Hyperglycemia in Mice.
Niemann-Pick Disease, Type A
Acid sphingomyelinase deficiency protects from cisplatin-induced gastrointestinal damage.
Niemann-Pick Disease, Type A
Acid sphingomyelinase deficiency protects mitochondria and improves function recovery after brain injury.
Niemann-Pick Disease, Type A
Acid sphingomyelinase deficiency. Phenotype variability with prevalence of intermediate phenotype in a series of twenty-five Czech and Slovak patients. A multi-approach study.
Niemann-Pick Disease, Type A
Acid sphingomyelinase deficiency: Cardiac dysfunction and characteristic findings of the coronary arteries.
Niemann-Pick Disease, Type A
Acid sphingomyelinase deficiency: prevalence and characterization of an intermediate phenotype of Niemann-Pick disease.
Niemann-Pick Disease, Type A
Acid Sphingomyelinase Inhibition Prevents Development of Sepsis Sequelae in the Murine Liver.
Niemann-Pick Disease, Type A
Acid sphingomyelinase possesses a domain homologous to its activator proteins: saposins B and D.
Niemann-Pick Disease, Type A
Adrenal changes in Niemann-Pick disease: differences between sphingomyelinase deficiency and type C.
Niemann-Pick Disease, Type A
Adult Niemann-Pick disease masquerading as sea blue histiocyte syndrome: report of a case confirmed by lipid analysis and enzyme assays.
Niemann-Pick Disease, Type A
Adult sphingomyelinase deficiency: report of 2 patients who initially presented with psychiatric disorders.
Niemann-Pick Disease, Type A
Altered Lipid Metabolism in Brain Injury and Disorders.
Niemann-Pick Disease, Type A
Altered lipid metabolism in brain injury and disorders.
Niemann-Pick Disease, Type A
Altered Macrophage Function Associated with Crystalline Lung Inflammation in Acid Sphingomyelinase Deficiency.
Niemann-Pick Disease, Type A
An animal model of human acid sphingomyelinase deficiency (Niemann-Pick disease) and the study of its enzyme replacement (the Japan Society of Human Genetics award lecture).
Niemann-Pick Disease, Type A
An Early-Onset Neuronopathic Form of Acid Sphingomyelinase Deficiency: A SMPD1 p.C133Y Mutation in the Saposin Domain of Acid Sphingomyelinase.
Niemann-Pick Disease, Type A
Application of a glycinated bile acid biomarker for diagnosis and assessment of response to treatment in Niemann-pick disease type C1.
Niemann-Pick Disease, Type A
Autopsy pathology of infantile neurovisceral ASMD (Niemann-Pick Disease type A): Clinicopathologic correlations of a case report.
Niemann-Pick Disease, Type A
Biochemical and imaging parameters in acid sphingomyelinase deficiency: Potential utility as biomarkers.
Niemann-Pick Disease, Type A
Burden of Illness in Acid Sphingomyelinase Deficiency: A Retrospective Chart Review of 100 Patients.
Niemann-Pick Disease, Type A
Case Report of Gastrointestinal Bleeding in an Adult with Chronic Visceral Acid Sphingomyelinase Deficiency.
Niemann-Pick Disease, Type A
Cause of death in patients with chronic visceral and chronic neurovisceral acid sphingomyelinase deficiency (Niemann-Pick disease type B and B variant): Literature review and report of new cases.
Niemann-Pick Disease, Type A
Chronic Niemann-Pick disease with sphingomyelinase deficiency in two brothers with mental retardation.
Niemann-Pick Disease, Type A
Chronic visceral acid sphingomyelinase deficiency (Niemann-Pick disease type B) in 16 Polish patients: long-term follow-up.
Niemann-Pick Disease, Type A
Clathrin-mediated endocytosis is impaired in type A-B Niemann-Pick disease model cells and can be restored by ICAM-1-mediated enzyme replacement.
Niemann-Pick Disease, Type A
Clearance of Hepatic Sphingomyelin by Olipudase Alfa Is Associated With Improvement in Lipid Profiles in Acid Sphingomyelinase Deficiency.
Niemann-Pick Disease, Type A
Clinical relevance of endpoints in clinical trials for acid sphingomyelinase deficiency enzyme replacement therapy.
Niemann-Pick Disease, Type A
Combined Emphysema and Interstitial Lung Disease as a Rare Presentation of Pulmonary Involvement in a Patient with Chronic Visceral Acid Sphingomyelinase Deficiency (Niemann-Pick Disease Type B).
Niemann-Pick Disease, Type A
Complex kinetics of bis(4-methylumbelliferyl)phosphate and hexadecanoyl(nitrophenyl)phosphorylcholine hydrolysis by purified sphingomyelinase in the presence of Triton X-100.
Niemann-Pick Disease, Type A
Consensus recommendation for a diagnostic guideline for acid sphingomyelinase deficiency.
Niemann-Pick Disease, Type A
Correction of sphingomyelinase deficiency in Niemann-Pick type C fibroblasts by removal of lipoprotein fraction from culture media.
Niemann-Pick Disease, Type A
Corrigendum to "Cause of death in patients with chronic visceral and chronic neurovisceral acid sphingomyelinase deficiency (Niemann-Pick disease type B and B variant): Literature review and report of new cases" [Mol. Genet. Metab. 118 (2016) 206-213].
Niemann-Pick Disease, Type A
Critical assessment of chitotriosidase analysis in the rational laboratory diagnosis of children with Gaucher disease and Niemann-Pick disease type A/B and C.
Niemann-Pick Disease, Type A
Deficiency of phospholipase C acting on phosphatidylglycerol in Niemann-Pick disease.
Niemann-Pick Disease, Type A
Deficiency of taurocholate-dependent phospholipase C acting on phosphatidylcholine in Niemann-Pick disease.
Niemann-Pick Disease, Type A
Deposition of lipopigment--a new feature of human splenic sinus endothelium (SSE). Ultrastructural and histochemical study.
Niemann-Pick Disease, Type A
Disease manifestations and burden of illness in patients with acid sphingomyelinase deficiency (ASMD).
Niemann-Pick Disease, Type A
Dual diagnosis of Ochoa syndrome and Niemann-Pick disease type B in a consanguineous family.
Niemann-Pick Disease, Type A
Effect of dimethylsulfoxide on sphingomyelinase activity and cholesterol metabolism in Niemann-Pick type C fibroblasts.
Niemann-Pick Disease, Type A
Effect of host cell lipid metabolism on alphavirus replication, virion morphogenesis, and infectivity.
Niemann-Pick Disease, Type A
Effects of acid sphingomyelinase deficiency on male germ cell development and programmed cell death.
Niemann-Pick Disease, Type A
Effects of dimethylsulfoxide on sphingomyelinase in cultured human fibroblasts and correction of sphingomyelinase deficiency in fibroblasts from Niemann-Pick patients.
Niemann-Pick Disease, Type A
Enhanced Delivery and Effects of Acid Sphingomyelinase by ICAM-1-Targeted Nanocarriers in Type B Niemann-Pick Disease Mice.
Niemann-Pick Disease, Type A
Functional characterization of novel variants in SMPD1 in Indian patients with acid sphingomyelinase deficiency.
Niemann-Pick Disease, Type A
Gelastic cataplexy in Niemann-Pick disease group C and related variants without generalized sphingomyelinase deficiency.
Niemann-Pick Disease, Type A
Homozygous pArg610del Mutation Unusually Associated With Severe Delay of Growth in 2 Acid Sphingomyelinase Deficiency-affected Sibs.
Niemann-Pick Disease, Type A
Identification and expression of a common missense mutation (L302P) in the acid sphingomyelinase gene of Ashkenazi Jewish type A Niemann-Pick disease patients.
Niemann-Pick Disease, Type A
Identification and expression of a missense mutation (Y446C) in the acid sphingomyelinase gene from a Japanese patient with type A Niemann-Pick disease.
Niemann-Pick Disease, Type A
Identification of a distinct mutation spectrum in the SMPD1 gene of Chinese patients with acid sphingomyelinase-deficient Niemann-Pick disease.
Niemann-Pick Disease, Type A
Inhibition of fatty acid amide hydrolase prevents pathology in neurovisceral acid sphingomyelinase deficiency by rescuing defective endocannabinoid signaling.
Niemann-Pick Disease, Type A
Interstitial lung disease in lysosomal storage disorders.
Niemann-Pick Disease, Type A
Ito cells in lysosomal storage disorders. An ultrastructural study.
Niemann-Pick Disease, Type A
Limited benefits of presymptomatic cord blood transplantation in neurovisceral acid sphingomyelinase deficiency (ASMD) intermediate type.
Niemann-Pick Disease, Type A
Lipid abnormalities in children with types A and B Niemann Pick disease.
Niemann-Pick Disease, Type A
Lipid abnormalities in foam cell reticulosis of mice, an analogue of human sphingomyelin lipidosis.
Niemann-Pick Disease, Type A
Liver and skin histopathology in adults with acid sphingomyelinase deficiency (Niemann-Pick disease type B).
Niemann-Pick Disease, Type A
Long-term efficacy of olipudase alfa in adults with acid sphingomyelinase deficiency (ASMD): Further clearance of hepatic sphingomyelin is associated with additional improvements in pro- and anti-atherogenic lipid profiles after 42 months of treatment.
Niemann-Pick Disease, Type A
Lysosomal involvement in cellular turnover of plasma membrane sphingomyelin.
Niemann-Pick Disease, Type A
Macula halo syndrome. Variant of Niemann-Pick disease.
Niemann-Pick Disease, Type A
Mitochondrial biogenesis is transcriptionally repressed in lysosomal lipid storage diseases.
Niemann-Pick Disease, Type A
Molecular analysis of the acid sphingomyelinase deficiency in a family with an intermediate form of Niemann-Pick disease.
Niemann-Pick Disease, Type A
Molecular basis of acid sphingomyelinase deficiency in a patient with Niemann-Pick disease type A.
Niemann-Pick Disease, Type A
MRI in an unusually protracted neuronopathic variant of acid sphingomyelinase deficiency.
Niemann-Pick Disease, Type A
New findings in pathology of storage.
Niemann-Pick Disease, Type A
Niemann-Pick disease and juvenile xanthogranuloma. Are they related?
Niemann-Pick Disease, Type A
Niemann-Pick disease type A and B are clinically but also enzymatically heterogeneous: pitfall in the laboratory diagnosis of sphingomyelinase deficiency associated with the mutation Q292 K.
Niemann-Pick Disease, Type A
Niemann-Pick disease type C. Pathological, histochemical, ultrastructural and biochemical studies.
Niemann-Pick Disease, Type A
Niemann-Pick Disease versus acid sphingomyelinase deficiency.
Niemann-Pick Disease, Type A
Niemann-Pick disease.
Niemann-Pick Disease, Type A
Niemann-Pick type C disease: Novel NPC1 mutations and characterization of the concomitant acid sphingomyelinase deficiency.
Niemann-Pick Disease, Type A
Niemann-Pick type C disease: The atypical sphingolipidosis.
Niemann-Pick Disease, Type A
Nonclinical safety assessment of recombinant human acid sphingomyelinase (rhASM) for the treatment of acid sphingomyelinase deficiency:the utility of animal models of disease in the toxicological evaluation of potential therapeutics.
Niemann-Pick Disease, Type A
Novel mutations in the SMPD1 gene in Jordanian children with Acid sphingomyelinase deficiency (Niemann-Pick types A and B).
Niemann-Pick Disease, Type A
Ocular manifestations of adult Niemann-Pick disease: a case report.
Niemann-Pick Disease, Type A
Ocular pathology of infantile Niemann-Pick disease. Study of fetus of 23 weeks' gestation.
Niemann-Pick Disease, Type A
Olipudase alfa for treatment of acid sphingomyelinase deficiency (ASMD): safety and efficacy in adults treated for 30 months.
Niemann-Pick Disease, Type A
One-year results of a clinical trial of olipudase alfa enzyme replacement therapy in pediatric patients with acid sphingomyelinase deficiency.
Niemann-Pick Disease, Type A
Optimization of a histopathological biomarker for sphingomyelin accumulation in Acid sphingomyelinase deficiency.
Niemann-Pick Disease, Type A
Oral, dental, and craniofacial features in chronic acid sphingomyelinase deficiency.
Niemann-Pick Disease, Type A
Partial sphingomyelinase deficiency with sea-blue histiocytosis and neurovisceral dysfunction.
Niemann-Pick Disease, Type A
Pathogenesis of one variant of sea-blue histiocytosis.
Niemann-Pick Disease, Type A
Periodontal condition and treatment in a patient with rare systemic condition: A case report for acid sphingomyelinase deficiency.
Niemann-Pick Disease, Type A
Peripheral neuropathy in type A Niemann-Pick disease. A morphological study.
Niemann-Pick Disease, Type A
Phenotypic and genetic heterogeneity in Niemann-Pick disease type C: current knowledge and practical implications.
Niemann-Pick Disease, Type A
Plasma lyso-sphingomyelin levels are positively associated with clinical severity in acid sphingomyelinase deficiency.
Niemann-Pick Disease, Type A
Polyneuropathy in feline Niemann-Pick disease.
Niemann-Pick Disease, Type A
Prospective study of the natural history of chronic acid sphingomyelinase deficiency in children and adults: eleven years of observation.
Niemann-Pick Disease, Type A
Quantitation of plasmatic lysosphingomyelin and lysosphingomyelin-509 for differential screening of Niemann-Pick A/B and C diseases.
Niemann-Pick Disease, Type A
Quantitative Systems Pharmacology Modeling of Acid Sphingomyelinase Deficiency and the Enzyme Replacement Therapy Olipudase Alfa Is an Innovative Tool for Linking Pathophysiology and Pharmacology.
Niemann-Pick Disease, Type A
Radiation-induced apoptosis of endothelial cells in the murine central nervous system: protection by fibroblast growth factor and sphingomyelinase deficiency.
Niemann-Pick Disease, Type A
Rapid screening for lipid storage disorders using biochemical markers. Expert center data and review of the literature.
Niemann-Pick Disease, Type A
Recommendations for clinical monitoring of patients with acid sphingomyelinase deficiency (ASMD).
Niemann-Pick Disease, Type A
Reconstruction of the Cytokine Signaling in Lysosomal Storage Diseases by Literature Mining and Network Analysis.
Niemann-Pick Disease, Type A
Regulation of Chlamydomonas flagella and ependymal cell motile cilia by ceramide-mediated translocation of GSK3.
Niemann-Pick Disease, Type A
Reliable Assay of Acid Sphingomyelinase Deficiency with the Mutation Q292K by Tandem Mass Spectrometry.
Niemann-Pick Disease, Type A
Respiratory impairment in Niemann-Pick B disease: Two case reports and review for the pulmonologist.
Niemann-Pick Disease, Type A
Serum Zn(2+)-stimulated sphingomyelinase deficiency in type B Niemann-Pick disease.
Niemann-Pick Disease, Type A
Seven novel mutations of the SMPD1 gene in four Chinese patients with Niemann-Pick disease type A and prenatal diagnosis for four fetuses.
Niemann-Pick Disease, Type A
Signaling in and regulation of ionizing radiation-induced apoptosis in endothelial cells.
Niemann-Pick Disease, Type A
Skeletal manifestations in pediatric and adult patients with Niemann Pick disease type B.
Niemann-Pick Disease, Type A
Sphingomyelin lipidosis (Niemann-Pick disease) in a juvenile raccoon (Procyon lotor).
Niemann-Pick Disease, Type A
Sphingomyelinase activities of various human tissues in control subjects and in Niemann-Pick disease - development and evaluation of a microprocedure.
Niemann-Pick Disease, Type A
Sphingomyelinase deficiency (Niemann-Pick disease) in a Hereford calf.
Niemann-Pick Disease, Type A
Splenic histiocytosis in idiopathic thrombocytopenic purpura: a relative sphingomyelinase deficiency?
Niemann-Pick Disease, Type A
Structural and functional analysis of the ASM p.Ala359Asp mutant that causes acid sphingomyelinase deficiency.
Niemann-Pick Disease, Type A
Subclinical course of adult visceral Niemann-Pick type C1 disease. A rare or underdiagnosed disorder?
Niemann-Pick Disease, Type A
Successful within-patient dose escalation of olipudase alfa in acid sphingomyelinase deficiency.
Niemann-Pick Disease, Type A
Synthesis of pyrenesulfonylamido-sphingomyelin and its use as substrate for determining sphingomyelinase activity and diagnosing Niemann-Pick disease.
Niemann-Pick Disease, Type A
The IL-1 receptor signaling pathway.
Niemann-Pick Disease, Type A
The impact of biomarkers analysis in the diagnosis of Niemann-Pick C disease and acid sphingomyelinase deficiency.
Niemann-Pick Disease, Type A
The natural history of type B Niemann-Pick disease: results from a 10-year longitudinal study.
Niemann-Pick Disease, Type A
Treatment of sphingomyelinase deficiency by repeated implantations of amniotic epithelial cells.
Niemann-Pick Disease, Type A
Tricyclic antidepressants induce sphingomyelinase deficiency in fibroblast and neuroblastoma cell cultures.
Niemann-Pick Disease, Type A
Twenty- five years of biochemical diagnosis of Gaucher disease: the Egyptian experience.
Niemann-Pick Disease, Type A
Two new mutations in the acid sphingomyelinase gene causing type a Niemann-pick disease: N389T and R441X.
Niemann-Pick Disease, Type A
Two novel mutations in patients with atypical phenotypes of acid sphingomyelinase deficiency.
Niemann-Pick Disease, Type A
Two Siblings with Niemann-Pick Disease (NPD) Type B: Clinical Findings and Novel Mutations of the Acid Sphingomyelinase Gene.
Niemann-Pick Disease, Type A
Type A Niemann-Pick disease: a frameshift mutation in the acid sphingomyelinase gene (fsP330) occurs in Ashkenazi Jewish patients.
Niemann-Pick Disease, Type A
Uptake and metabolism of radioactively labeled sphingomyelin in cultured skin fibroblasts from controls and patients with Niemann-Pick disease and other lysosomal storage diseases.
Niemann-Pick Disease, Type A
[Acid sphingomyelinase deficiency (Niemann-Pick disease type B) in adulthood: A retrospective multicentric study of 28 adult cases].
Niemann-Pick Disease, Type A
[Acid sphingomyelinase deficiency and spleen trauma: Splenectomy or not splenectomy?]
Niemann-Pick Disease, Type A
[Activators for sphingohydrolases and the nature of the sphingomyelinase deficiency in Niemann-Pick disease types A, B and C (author's transl)]
Niemann-Pick Disease, Type A
[Lipidosis with vertical gaze palsy, macular degeneration, and sphingomyelinase deficiency]
Niemann-Pick Disease, Type A
[Lysosomal sphingomyelinase deficiency: spectrum of phenotypes in Czech and Slovak patients]
Niemann-Pick Disease, Type A
[Niemann-Pick disease revealed late by miliary tuberculosis: diagnosis by leukocyte determination of sphingomyelinase deficiency]
Niemann-Pick Disease, Type A
[Perhexiline maleate induces sphingomyelinase deficiency in man]
Niemann-Pick Disease, Type A
[Sea-blue histiocyte syndrome (author's transl)]
Niemann-Pick Disease, Type A
[Sphingomyelinase deficiency (Niemann-Pick) type A. A new variant with an unusually prolonged course]
Niemann-Pick Disease, Type A
[Study of thesaurismosis induced by perhexiline maleate. Confirmation of experimental data]
Niemann-Pick Disease, Type B
A novel missense mutation of the SMPD1 gene in a Taiwanese patient with type B Niemann-Pick disease.
Niemann-Pick Disease, Type B
A novel SMPD1 mutation in two Chinese sibling patients with type B Niemann-Pick disease.
Niemann-Pick Disease, Type B
Acid sphingomyelinase overexpression enhances the antineoplastic effects of irradiation in vitro and in vivo.
Niemann-Pick Disease, Type B
Delivery of acid sphingomyelinase in normal and niemann-pick disease mice using intercellular adhesion molecule-1-targeted polymer nanocarriers.
Niemann-Pick Disease, Type B
Elevated sphingomyelinase and hypercytokinemia in hemophagocytic lymphohistiocytosis.
Niemann-Pick Disease, Type B
Enhanced Delivery and Effects of Acid Sphingomyelinase by ICAM-1-Targeted Nanocarriers in Type B Niemann-Pick Disease Mice.
Niemann-Pick Disease, Type B
ICAM-1 targeting, intracellular trafficking, and functional activity of polymer nanocarriers coated with a fibrinogen-derived peptide for lysosomal enzyme replacement.
Niemann-Pick Disease, Type B
Identification of a missense mutation (S436R) in the acid sphingomyelinase gene from a Japanese patient with type B Niemann-Pick disease.
Niemann-Pick Disease, Type B
Ophthalmologic manifestations of type B Niemann-Pick diseases.
Niemann-Pick Disease, Type B
R542X mutation in SMPD1 gene: genetically novel mutation with phenotypic features intermediate between type A and type B Niemann-Pick disease.
Niemann-Pick Disease, Type B
Recombinant human acid sphingomyelinase as an adjuvant to sorafenib treatment of experimental liver cancer.
Niemann-Pick Disease, Type B
Reduced cellular cholesterol efflux and low plasma high-density lipoprotein cholesterol in a patient with type B Niemann-Pick disease because of a novel SMPD-1 mutation.
Niemann-Pick Disease, Type B
Serum Zn(2+)-stimulated sphingomyelinase deficiency in type B Niemann-Pick disease.
Niemann-Pick Disease, Type B
The natural history of type B Niemann-Pick disease: results from a 10-year longitudinal study.
Niemann-Pick Disease, Type B
Uptake and metabolism of radioactively labeled sphingomyelin in cultured skin fibroblasts from controls and patients with Niemann-Pick disease and other lysosomal storage diseases.
Niemann-Pick Disease, Type C
A progressive neurologic disorder with supranuclear vertical gaze paresis and distinctive bone marrow cells.
Niemann-Pick Disease, Type C
Biochemical and ultrastructural studies on an Epstein-Barr virus-transformed lymphoid cell line from a Niemann-Pick disease type C patient.
Niemann-Pick Disease, Type C
Chromatofocusing of skin fibroblast sphingomyelinase: alterations in Niemann-Pick disease type C shared by GM1-gangliosidosis.
Niemann-Pick Disease, Type C
Critical assessment of chitotriosidase analysis in the rational laboratory diagnosis of children with Gaucher disease and Niemann-Pick disease type A/B and C.
Niemann-Pick Disease, Type C
Effects of dimethylsulfoxide on sphingomyelinase activities in normal and Niemann-Pick type A, B and C fibroblasts.
Niemann-Pick Disease, Type C
Isoenzymes of sphingomyelinase and the genetic defect in Niemann-Pick disease, type C.
Niemann-Pick Disease, Type C
Juvenile dystonic lipidosis (variant of Niemann-Pick disease type C).
Niemann-Pick Disease, Type C
Macrophage uptake of oxidized LDL inhibits lysosomal sphingomyelinase, thus causing the accumulation of unesterified cholesterol-sphingomyelin-rich particles in the lysosomes. A possible role for 7-Ketocholesterol.
Niemann-Pick Disease, Type C
Morphological diagnosis of Niemann-Pick disease type C by skin and conjunctival biopsies.
Niemann-Pick Disease, Type C
Niemann-Pick disease type C: an update.
Niemann-Pick Disease, Type C
Niemann-Pick disease type D: lipid analyses and studies on sphingomyelinases.
Niemann-Pick Disease, Type C
Niemann-Pick disease, Type C: evidence for the deficiency of an activating factor stimulating sphingomyelin and glucocerebroside degradation.
Niemann-Pick Disease, Type C
Niemann-Pick disease: coupling and uncoupling of inhibited sphingomyelinase activity and exogenous cholesterol esterification in fibroblasts by ionophore treatment.
Niemann-Pick Disease, Type C
Niemann-Pick diseases.
Niemann-Pick Disease, Type C
Niemann-Pick type C disease: Novel NPC1 mutations and characterization of the concomitant acid sphingomyelinase deficiency.
Niemann-Pick Disease, Type C
Posttranslational regulation of acid sphingomyelinase in niemann-pick type C1 fibroblasts and free cholesterol-enriched chinese hamster ovary cells.
Niemann-Pick Disease, Type C
Prenatal diagnosis of Niemann-Pick disease type C.
Niemann-Pick Disease, Type C
Quantitation of plasmatic lysosphingomyelin and lysosphingomyelin-509 for differential screening of Niemann-Pick A/B and C diseases.
Niemann-Pick Disease, Type C
Rapid screening for lipid storage disorders using biochemical markers. Expert center data and review of the literature.
Niemann-Pick Disease, Type C
Resolution of tissue sphingomyelinase isoelectric profile in multiple components is extraction-dependent: evidence for a component defect in Niemann-Pick disease type C is spurious.
Niemann-Pick Disease, Type C
Sphingomyelin storage in a patient with myoclonus epilepsy as a main clinical symptom -- a varient in Niemann-Pick disease type C.
Niemann-Pick Disease, Type C
Sphingomyelinase activities of various human tissues in control subjects and in Niemann-Pick disease - development and evaluation of a microprocedure.
Niemann-Pick Disease, Type C
Sphingomyelinase and nonspecific phosphodiesterase activities in Epstein-Barr virus-transformed lymphoid cell lines from Niemann-Pick disease A, B and C.
Niemann-Pick Disease, Type C
Sphingomyelinase defect in Niemann-Pick disease, type C, fibroblasts.
Niemann-Pick Disease, Type C
Sphingomyelinase in cultured skin fibroblasts from normal and Niemann-Pick type C patients.
Niemann-Pick Disease, Type C
Subclinical course of adult visceral Niemann-Pick type C1 disease. A rare or underdiagnosed disorder?
Niemann-Pick Disease, Type C
The impact of biomarkers analysis in the diagnosis of Niemann-Pick C disease and acid sphingomyelinase deficiency.
Niemann-Pick Disease, Type C
[Niemann-Pick disease type C (subacute neurovisceral lipidosis). Problems of altered sphingomyelinase activity in the brain (author's transl)]
Niemann-Pick Diseases
?-Tocopherol Effect on Endocytosis and Its Combination with Enzyme Replacement Therapy for Lysosomal Disorders: A New Type of Drug Interaction?
Niemann-Pick Diseases
A family with visceral course of Niemann-Pick disease, macular halo syndrome and low sphingomyelin degradation rate.
Niemann-Pick Diseases
A fluorescence-based, high-performance liquid chromatographic assay to determine acid sphingomyelinase activity and diagnose types A and B Niemann-Pick disease.
Niemann-Pick Diseases
A fluorescence-based, high-throughput sphingomyelin assay for the analysis of Niemann-Pick disease and other disorders of sphingomyelin metabolism.
Niemann-Pick Diseases
A fluorometric determination of sphingomyelinase by use of fluorescent derivatives of sphingomyelin, and its application to diagnosis of Niemann-Pick disease.
Niemann-Pick Diseases
A micromethod for sphingomyelinase assay using a chromogenic artificial substrate. Its use in the diagnosis of Niemann-Pick disease.
Niemann-Pick Diseases
A micromethod for sphingomyelinase assay using a chromogenic artificial substrate: its use in the diagnosis of Niemann-Pick disease.
Niemann-Pick Diseases
A neutral sphingomyelinase resides in sphingolipid-enriched microdomains and is inhibited by the caveolin-scaffolding domain: potential implications in tumour necrosis factor signalling.
Niemann-Pick Diseases
A new form of Niemann-Pick disease characterised by temperature-labile sphingomyelinase.
Niemann-Pick Diseases
A novel missense mutation of the SMPD1 gene in a Taiwanese patient with type B Niemann-Pick disease.
Niemann-Pick Diseases
A novel missense SMPD1 gene mutation, T460P, and clinical findings in a patient with Niemann-Pick disease type B presenting to a lipid disorders clinic.
Niemann-Pick Diseases
A novel SMPD1 mutation in two Chinese sibling patients with type B Niemann-Pick disease.
Niemann-Pick Diseases
A practical chromogenic procedure for the detection of homozygotes and heterozygous carriers of Niemann-Pick disease.
Niemann-Pick Diseases
A profound deficiency of (CH3-14C)choline sphingomyelin-cleaving enzyme in Niemann-Pick disease type B.
Niemann-Pick Diseases
A progressive neurologic disorder with supranuclear vertical gaze paresis and distinctive bone marrow cells.
Niemann-Pick Diseases
AAV8-mediated hepatic expression of acid sphingomyelinase corrects the metabolic defect in the visceral organs of a mouse model of Niemann-Pick disease.
Niemann-Pick Diseases
Accurate differentiation of neuronopathic and nonneuronopathic forms of Niemann-Pick disease by evaluation of the effective residual lysosomal sphingomyelinase activity in intact cells.
Niemann-Pick Diseases
Acid sphingomyelinase (Asm) deficiency patients in The Netherlands and Belgium: Disease spectrum and natural course in attenuated patients.
Niemann-Pick Diseases
Acid sphingomyelinase (aSMase) deficiency leads to abnormal microglia behavior and disturbed retinal function.
Niemann-Pick Diseases
Acid sphingomyelinase deficiency does not protect from graft-versus-host disease in transplant recipients with Niemann-Pick disease.
Niemann-Pick Diseases
Acid sphingomyelinase deficiency exacerbates LPS-induced experimental periodontitis.
Niemann-Pick Diseases
Acid sphingomyelinase deficiency. Phenotype variability with prevalence of intermediate phenotype in a series of twenty-five Czech and Slovak patients. A multi-approach study.
Niemann-Pick Diseases
Acid sphingomyelinase deficiency: prevalence and characterization of an intermediate phenotype of Niemann-Pick disease.
Niemann-Pick Diseases
Acid sphingomyelinase deficient mice: a model of types A and B Niemann-Pick disease.
Niemann-Pick Diseases
Acid sphingomyelinase is not essential for the IL-1 and tumor necrosis factor receptor signaling pathway leading to NFkB activation.
Niemann-Pick Diseases
Acid sphingomyelinase overexpression enhances the antineoplastic effects of irradiation in vitro and in vivo.
Niemann-Pick Diseases
Acid sphingomyelinase possesses a domain homologous to its activator proteins: saposins B and D.
Niemann-Pick Diseases
Acid sphingomyelinase, cell membranes and human disease: lessons from Niemann-Pick disease.
Niemann-Pick Diseases
Acid sphingomyelinase: identification of nine novel mutations among Italian Niemann Pick type B patients and characterization of in vivo functional in-frame start codon.
Niemann-Pick Diseases
Acidic sphingomyelinase (ASM) is necessary for fas-induced GD3 ganglioside accumulation and efficient apoptosis of lymphoid cells.
Niemann-Pick Diseases
Activation of human acid sphingomyelinase through modification or deletion of C-terminal cysteine.
Niemann-Pick Diseases
Adrenal changes in Niemann-Pick disease: differences between sphingomyelinase deficiency and type C.
Niemann-Pick Diseases
Adult sphingomyelinase deficiency: report of 2 patients who initially presented with psychiatric disorders.
Niemann-Pick Diseases
Adult-onset pulmonary involvement in Niemann-Pick disease type B.
Niemann-Pick Diseases
Alleged Detrimental Mutations in the SMPD1 Gene in Patients with Niemann-Pick Disease.
Niemann-Pick Diseases
Allogeneic bone marrow-plus-liver transplantation in the C57BL/KsJ spm/spm mouse, an animal model of Niemann-Pick disease.
Niemann-Pick Diseases
Alpha galactosidase A activity in Parkinson's disease.
Niemann-Pick Diseases
Alterations of myelin-specific proteins and sphingolipids characterize the brains of acid sphingomyelinase-deficient mice, an animal model of Niemann-Pick disease type A.
Niemann-Pick Diseases
Altered Lipid Metabolism in Brain Injury and Disorders.
Niemann-Pick Diseases
Altered lipid metabolism in brain injury and disorders.
Niemann-Pick Diseases
Alveolar lipoproteinosis in an acid sphingomyelinase-deficient mouse model of Niemann-Pick disease.
Niemann-Pick Diseases
An Early-Onset Neuronopathic Form of Acid Sphingomyelinase Deficiency: A SMPD1 p.C133Y Mutation in the Saposin Domain of Acid Sphingomyelinase.
Niemann-Pick Diseases
An enzymatic assay for quantifying sphingomyelin in tissues and plasma from humans and mice with Niemann-Pick disease.
Niemann-Pick Diseases
An induced pluripotent stem cell line (TRNDi009-C) from a Niemann-Pick disease type A patient carrying a heterozygous p.L302P (c.905 T>C) mutation in the SMPD1 gene.
Niemann-Pick Diseases
An ultramicrochemical assay for sphingomyelinase: rapid prenatal diagnosis of a fetus at risk for Niemann-Pick disease.
Niemann-Pick Diseases
Analysis of Acid sphingomyelinase activity in dried blood spots using tandem mass spectrometry.
Niemann-Pick Diseases
Analysis of the lung pathology and alveolar macrophage function in the acid sphingomyelinase--deficient mouse model of Niemann-Pick disease.
Niemann-Pick Diseases
Analysis of the sphingomyelin phosphodiesterase 1 gene (SMPD1) in Turkish Niemann-Pick disease patients: mutation profile and description of a novel mutation.
Niemann-Pick Diseases
Anti-human class I MHC antibodies induce apoptosis by a pathway that is distinct from the Fas antigen-mediated pathway.
Niemann-Pick Diseases
Assay of beta-glucosidase and sphingomyelinase for identification of patients and carriers of Gaucher's and Niemann-Pick diseases.
Niemann-Pick Diseases
Autopsy pathology of infantile neurovisceral ASMD (Niemann-Pick Disease type A): Clinicopathologic correlations of a case report.
Niemann-Pick Diseases
Bi-functional IgG-lysosomal enzyme fusion proteins for brain drug delivery.
Niemann-Pick Diseases
Biochemical and ultrastructural findings in a lymphoid cell line from Niemann-Pick disease type A.
Niemann-Pick Diseases
Biochemical and ultrastructural studies on an Epstein-Barr virus-transformed lymphoid cell line from a Niemann-Pick disease type C patient.
Niemann-Pick Diseases
Biochemical studies in Niemann-Pick disease. III. In vitro and in vivo assays of sphingomyelin degradation in cultured skin fibroblasts and amniotic fluid cells for the diagnosis of the various forms of the disease.
Niemann-Pick Diseases
Biochemical, pathological, and clinical response to transplantation of normal bone marrow cells into acid sphingomyelinase-deficient mice.
Niemann-Pick Diseases
Biosynthesis of sphingomyelinase in normal and Niemann-Pick fibroblasts.
Niemann-Pick Diseases
Bone marrow transplantation in acid sphingomyelinase-deficient mice: engraftment and cell migration into the brain as a function of radiation, age, and phenotype.
Niemann-Pick Diseases
Brain pathology in Niemann Pick disease type A: insights from the acid sphingomyelinase knockout mice.
Niemann-Pick Diseases
Cathepsin B overexpression due to acid sphingomyelinase ablation promotes liver fibrosis in Niemann-Pick disease.
Niemann-Pick Diseases
CD95 (Fas/APO-1) induces ceramide formation and apoptosis in the absence of a functional acid sphingomyelinase.
Niemann-Pick Diseases
Cell autonomous apoptosis defects in acid sphingomyelinase knockout fibroblasts.
Niemann-Pick Diseases
Changes in PCSK 9 and apolipoprotein B100 in Niemann-Pick disease after enzyme replacement therapy with olipudase alfa.
Niemann-Pick Diseases
Characterization of common SMPD1 mutations causing types A and B Niemann-Pick disease and generation of mutation-specific mouse models.
Niemann-Pick Diseases
Characterization of human acid sphingomyelinase purified from the media of overexpressing Chinese hamster ovary cells.
Niemann-Pick Diseases
Characterization of Niemann-Pick diseases genes mutation spectrum in Iran and identification of a novel mutation in SMPD1 gene.
Niemann-Pick Diseases
Chemical and biochemical studies in fetuses affected with Nieman-Pick disease type A.
Niemann-Pick Diseases
Chemical and biochemical studies in human fetuses affected with Niemann-Pick disease type A.
Niemann-Pick Diseases
Chromatofocusing of skin fibroblast sphingomyelinase: alterations in Niemann-Pick disease type C shared by GM1-gangliosidosis.
Niemann-Pick Diseases
Chronic Niemann-Pick disease with sphingomyelinase deficiency in two brothers with mental retardation.
Niemann-Pick Diseases
Clathrin-mediated endocytosis is impaired in type A-B Niemann-Pick disease model cells and can be restored by ICAM-1-mediated enzyme replacement.
Niemann-Pick Diseases
Clearance of Hepatic Sphingomyelin by Olipudase Alfa Is Associated With Improvement in Lipid Profiles in Acid Sphingomyelinase Deficiency.
Niemann-Pick Diseases
Clinical and biochemical diagnostics of Niemann-Pick disease.
Niemann-Pick Diseases
Clinical relevance of endpoints in clinical trials for acid sphingomyelinase deficiency enzyme replacement therapy.
Niemann-Pick Diseases
Clinical, biochemical, and genotype-phenotype correlations of 118 patients with Niemann-Pick disease Types A/B.
Niemann-Pick Diseases
Combination brain and systemic injections of AAV provide maximal functional and survival benefits in the Niemann-Pick mouse.
Niemann-Pick Diseases
Combination-targeting to multiple endothelial cell adhesion molecules modulates binding, endocytosis, and in vivo biodistribution of drug nanocarriers and their therapeutic cargoes.
Niemann-Pick Diseases
Combined Emphysema and Interstitial Lung Disease as a Rare Presentation of Pulmonary Involvement in a Patient with Chronic Visceral Acid Sphingomyelinase Deficiency (Niemann-Pick Disease Type B).
Niemann-Pick Diseases
Comparative binding, endocytosis, and biodistribution of antibodies and antibody-coated carriers for targeted delivery of lysosomal enzymes to ICAM-1 versus transferrin receptor.
Niemann-Pick Diseases
Comparative effects of recombinant acid sphingomyelinase administration by different routes in niemann-pick disease mice.
Niemann-Pick Diseases
Compound heterozygosity at the sphingomyelin phosphodiesterase-1 (SMPD1) gene is associated with low HDL cholesterol.
Niemann-Pick Diseases
Comprehensive Evaluation of Plasma 7-Ketocholesterol and Cholestan-3?,5?,6?-Triol in an Italian Cohort of Patients Affected by Niemann-Pick Disease due to NPC1 and SMPD1 Mutations.
Niemann-Pick Diseases
Connecting Hsp70, sphingolipid metabolism and lysosomal stability.
Niemann-Pick Diseases
Creation of a mouse model for non-neurological (type B) Niemann-Pick disease by stable, low level expression of lysosomal sphingomyelinase in the absence of secretory sphingomyelinase: relationship between brain intra-lysosomal enzyme activity and central nervous system function.
Niemann-Pick Diseases
Critical assessment of chitotriosidase analysis in the rational laboratory diagnosis of children with Gaucher disease and Niemann-Pick disease type A/B and C.
Niemann-Pick Diseases
Crystal structure of mammalian acid sphingomyelinase.
Niemann-Pick Diseases
Cutting Edge of the Pathogenesis of Atopic Dermatitis: Sphingomyelin Deacylase, the Enzyme Involved in Its Ceramide Deficiency, Plays a Pivotal Role.
Niemann-Pick Diseases
Decreasing SMPD1 activity in BEAS-2B bronchial airway epithelial cells results in increased NRF2 activity, cytokine synthesis and neutrophil recruitment.
Niemann-Pick Diseases
Deep sequencing of SMPD1 gene revealed a heterozygous frameshift mutation (p.Ser192Alafs) in a Palestinian infant with Niemann-Pick disease type A: a case report.
Niemann-Pick Diseases
Defective Autophagy, Mitochondrial Clearance and Lipophagy in Niemann-Pick Type B Lymphocytes.
Niemann-Pick Diseases
Defects in sarcolemma repair and skeletal muscle function after injury in a mouse model of Niemann-Pick type A/B disease.
Niemann-Pick Diseases
Deficiency of taurocholate-dependent phospholipase C acting on phosphatidylcholine in Niemann-Pick disease.
Niemann-Pick Diseases
Degradation of lysophosphatidylcholine by lysosomes. Stimulation of lysophospholipase C by taurocholate and deficiency in Niemann-Pick fibroblasts.
Niemann-Pick Diseases
Deletion of arginine (608) in acid sphingomyelinase is the prevalent mutation among Niemann-Pick disease type B patients from northern Africa.
Niemann-Pick Diseases
Delivery of acid sphingomyelinase in normal and niemann-pick disease mice using intercellular adhesion molecule-1-targeted polymer nanocarriers.
Niemann-Pick Diseases
Depletion of Host and Viral Sphingomyelin Impairs Influenza Virus Infection.
Niemann-Pick Diseases
Determination of 7-ketocholesterol in plasma by LC-MS for rapid diagnosis of acid SMase-deficient Niemann-Pick disease.
Niemann-Pick Diseases
Diagnosis of Niemann-Pick disease using a simple and sensitive fluorimetric assay of sphingomyelinase activity.
Niemann-Pick Diseases
Dot immunodetection for sphingomyelinase with monoclonal antibody.
Niemann-Pick Diseases
Dual diagnosis of Ochoa syndrome and Niemann-Pick disease type B in a consanguineous family.
Niemann-Pick Diseases
Effect of host cell lipid metabolism on alphavirus replication, virion morphogenesis, and infectivity.
Niemann-Pick Diseases
Effects of dimethylsulfoxide on sphingomyelinase activities in normal and Niemann-Pick type A, B and C fibroblasts.
Niemann-Pick Diseases
Effects of sphingomyelin/ceramide ratio on the permeability and microstructure of model stratum corneum lipid membranes.
Niemann-Pick Diseases
Elevated sphingomyelinase and hypercytokinemia in hemophagocytic lymphohistiocytosis.
Niemann-Pick Diseases
Enhanced Delivery and Effects of Acid Sphingomyelinase by ICAM-1-Targeted Nanocarriers in Type B Niemann-Pick Disease Mice.
Niemann-Pick Diseases
Enzyme activities and phospholipid storage patterns in brain and spleen samples from Niemann-Pick disease variants: a comparison of neuropathic and non-neuropathic forms.
Niemann-Pick Diseases
Epidemiological, clinical and biochemical characterization of the p.(Ala359Asp) SMPD1 variant causing Niemann-Pick disease type B.
Niemann-Pick Diseases
ESI-MS quantitation of increased sphingomyelin in Niemann-Pick disease type B HDL.
Niemann-Pick Diseases
Evidence for the association of ultraviolet-C and H(2)O(2)-induced apoptosis with acid sphingomyelinase activation.
Niemann-Pick Diseases
Excess sphingomyelin disturbs ATG9A trafficking and autophagosome closure.
Niemann-Pick Diseases
Facile Method for Specifically Sensing Sphingomyelinase in Cells and Human Urine Based on a Ratiometric Fluorescent Nanoliposome Probe.
Niemann-Pick Diseases
Fatal Postpartum Hemorrhage in a Patient with Niemann-Pick Disease Type B.
Niemann-Pick Diseases
Feline Niemann-Pick Disease With a Novel Mutation of SMPD1 Gene.
Niemann-Pick Diseases
Fluorescence-based selection of retrovirally transduced cells in the absence of a marker gene: direct selection of transduced type B Niemann-Pick disease cells and evidence for bystander correction.
Niemann-Pick Diseases
Four novel p.N385K, p.V36A, c.1033-1034insT and c.1417-1418delCT mutations in the sphingomyelin Phosphodiesterase 1 (SMPD1) gene in patients with types A and B Niemann-Pick disease (NPD).
Niemann-Pick Diseases
Functional analysis of acid and neutral sphingomyelinases in vitro and in vivo.
Niemann-Pick Diseases
Functional characterization of novel variants in SMPD1 in Indian patients with acid sphingomyelinase deficiency.
Niemann-Pick Diseases
Functional in vitro characterization of 14 SMPD1 mutations identified in Italian patients affected by Niemann Pick Type B disease.
Niemann-Pick Diseases
Gelastic cataplexy in Niemann-Pick disease group C and related variants without generalized sphingomyelinase deficiency.
Niemann-Pick Diseases
Generation of an induced pluripotent stem cell line (TRNDi004-I) from a Niemann-Pick disease type B patient carrying a heterozygous mutation of p.L43_A44delLA in the SMPD1 gene.
Niemann-Pick Diseases
Hematopoietic stem cell gene therapy leads to marked visceral organ improvements and a delayed onset of neurological abnormalities in the acid sphingomyelinase deficient mouse model of Niemann-Pick disease.
Niemann-Pick Diseases
Hepatosplenomegaly, pneumopathy, bone changes and fronto-temporal dementia: Niemann-Pick type B and SQSTM1-associated Paget's disease in the same individual.
Niemann-Pick Diseases
High performance liquid chromatography for the detection of homozygotes and heterozygotes of Niemann-Pick disease.
Niemann-Pick Diseases
High sphingomyelin levels induce lysosomal damage and autophagy dysfunction in Niemann Pick disease type A.
Niemann-Pick Diseases
Highly variable neural involvement in sphingomyelinase-deficient Niemann-Pick disease caused by an ancestral Gypsy mutation.
Niemann-Pick Diseases
Hsp70 stabilizes lysosomes and reverts Niemann-Pick disease-associated lysosomal pathology.
Niemann-Pick Diseases
Human acid sphingomyelinase structures provide insight to molecular basis of Niemann-Pick disease.
Niemann-Pick Diseases
Human acid sphingomyelinase.
Niemann-Pick Diseases
ICAM-1 targeting, intracellular trafficking, and functional activity of polymer nanocarriers coated with a fibrinogen-derived peptide for lysosomal enzyme replacement.
Niemann-Pick Diseases
Identification and characterization of eight novel SMPD1 mutations causing types A and B Niemann-Pick disease.
Niemann-Pick Diseases
Identification and characterization of SMPD1 mutations causing Niemann-Pick types A and B in Spanish patients.
Niemann-Pick Diseases
Identification and expression of a common missense mutation (L302P) in the acid sphingomyelinase gene of Ashkenazi Jewish type A Niemann-Pick disease patients.
Niemann-Pick Diseases
Identification and expression of a missense mutation (Y446C) in the acid sphingomyelinase gene from a Japanese patient with type A Niemann-Pick disease.
Niemann-Pick Diseases
Identification and expression of five mutations in the human acid sphingomyelinase gene causing types A and B Niemann-Pick disease. Molecular evidence for genetic heterogeneity in the neuronopathic and non-neuronopathic forms.
Niemann-Pick Diseases
Identification of a 3' acceptor splice site mutation (g2610c) in the acid sphingomyelinase gene of patients with Niemann-Pick disease.
Niemann-Pick Diseases
Identification of a distinct mutation spectrum in the SMPD1 gene of Chinese patients with acid sphingomyelinase-deficient Niemann-Pick disease.
Niemann-Pick Diseases
Identification of a missense mutation (S436R) in the acid sphingomyelinase gene from a Japanese patient with type B Niemann-Pick disease.
Niemann-Pick Diseases
Identification of novel biomarkers for niemann-pick disease using gene expression analysis of Acid sphingomyelinase knockout mice.
Niemann-Pick Diseases
Identification of seven novel SMPD1 mutations causing Niemann-Pick disease types A and B.
Niemann-Pick Diseases
Imaging of pulmonary manifestations in subtype B of Niemann-Pick disease.
Niemann-Pick Diseases
Immunological studies on lysosomal sphingomyelinase: identification of a 28 000-Da component deficient in urine from patients with Niemann-Pick disease types A and B.
Niemann-Pick Diseases
Imprinting at the SMPD1 locus: implications for acid sphingomyelinase-deficient Niemann-Pick disease.
Niemann-Pick Diseases
Improved sensitivity of an acid sphingomyelinase activity assay using a C6:0 sphingomyelin substrate.
Niemann-Pick Diseases
Improvement of biochemical and behavioral defects in the Niemann-Pick type A mouse by intraventricular infusion of MARCKS.
Niemann-Pick Diseases
In Silico Analysis of the Molecular-Level Impact of SMPD1 Variants on Niemann-Pick Disease Severity.
Niemann-Pick Diseases
Induced Pluripotent Stem Cells for Disease Modeling and Evaluation of Therapeutics for Niemann-Pick Disease Type A.
Niemann-Pick Diseases
Infusion of recombinant human acid sphingomyelinase into niemann-pick disease mice leads to visceral, but not neurological, correction of the pathophysiology.
Niemann-Pick Diseases
Interstitial lung disease in lysosomal storage disorders.
Niemann-Pick Diseases
Intertwined mechanisms define transport of anti-ICAM nanocarriers across the endothelium and brain delivery of a therapeutic enzyme.
Niemann-Pick Diseases
Intracerebral transplantation of adult mouse neural progenitor cells into the Niemann-Pick-A mouse leads to a marked decrease in lysosomal storage pathology.
Niemann-Pick Diseases
Intracerebral transplantation of mesenchymal stem cells into acid sphingomyelinase-deficient mice delays the onset of neurological abnormalities and extends their life span.
Niemann-Pick Diseases
In vivo performance of polymer nanocarriers dually-targeted to epitopes of the same or different receptors.
Niemann-Pick Diseases
Isoenzymes of sphingomyelinase and the genetic defect in Niemann-Pick disease, type C.
Niemann-Pick Diseases
Juvenile dystonic lipidosis (variant of Niemann-Pick disease type C).
Niemann-Pick Diseases
Lack of Acid Sphingomyelinase Induces Age-Related Retinal Degeneration.
Niemann-Pick Diseases
Letters: A simple sphingomyelinase determination for Niemann-Pick disease: differential diagnosis of types A, B and C.
Niemann-Pick Diseases
Light and electron microscopic analysis of the central and peripheral nervous systems of acid sphingomyelinase-deficient mice resulting from gene targeting.
Niemann-Pick Diseases
Limited benefits of presymptomatic cord blood transplantation in neurovisceral acid sphingomyelinase deficiency (ASMD) intermediate type.
Niemann-Pick Diseases
Liposome-targeted recombinant human acid sphingomyelinase: Production, formulation, and in vitro evaluation.
Niemann-Pick Diseases
Liver and skin histopathology in adults with acid sphingomyelinase deficiency (Niemann-Pick disease type B).
Niemann-Pick Diseases
Lyso-sphingomyelin is elevated in dried blood spots of Niemann-Pick B patients.
Niemann-Pick Diseases
Lysosomal enzyme delivery by ICAM-1-targeted nanocarriers bypassing glycosylation- and clathrin-dependent endocytosis.
Niemann-Pick Diseases
Lysosomal involvement in cellular turnover of plasma membrane sphingomyelin.
Niemann-Pick Diseases
Macula halo syndrome and non-pitting lid oedema in an Italian family.
Niemann-Pick Diseases
Macula halo syndrome.
Niemann-Pick Diseases
Macula halo syndrome. Variant of Niemann-Pick disease.
Niemann-Pick Diseases
Mannose 6-phosphate receptor-mediated uptake is defective in acid sphingomyelinase-deficient macrophages: implications for Niemann-Pick disease enzyme replacement therapy.
Niemann-Pick Diseases
Merits of Combination Cortical, Subcortical, and Cerebellar Injections for the Treatment of Niemann-Pick Disease Type A.
Niemann-Pick Diseases
Modulating cancer cell survival by targeting intracellular cholesterol transport.
Niemann-Pick Diseases
Modulation of subcellular distribution of doxorubicin in multidrug-resistant P388/ADR mouse leukemia cells by the chemosensitizer ((2-isopropyl-1-(4-[3-N-methyl-N-(3,4-dimethoxy-beta- phenethyl)amino]propyloxy)-benzenesulfonyl))indolizine.
Niemann-Pick Diseases
Molecular analysis of the acid sphingomyelinase deficiency in a family with an intermediate form of Niemann-Pick disease.
Niemann-Pick Diseases
Molecular basis of acid sphingomyelinase deficiency in a patient with Niemann-Pick disease type A.
Niemann-Pick Diseases
Molecular forms of sphingomyelinase and non-specific phosphodiesterases in Epstein-Barr virus-transformed lymphoid cell lines from Niemann-Pick disease types A and B.
Niemann-Pick Diseases
Molecular genetic characterization of novel sphingomyelin phosphodiesterase 1 mutations causing niemann-pick disease.
Niemann-Pick Diseases
Morphological diagnosis of Niemann-Pick disease type C by skin and conjunctival biopsies.
Niemann-Pick Diseases
MRI-guided delivery of AAV2 to the primate brain for the treatment of lysosomal storage disorders.
Niemann-Pick Diseases
Mutational spectrum of SMPD1 gene in Pakistani Niemann-Pick disease patients.
Niemann-Pick Diseases
Neurofibrillary tangles in Niemann-Pick disease type C.
Niemann-Pick Diseases
New Single Nucleotide Deletion In the SMPD1 Gene Causes Niemann Pick Disease Type A in a Child from Southwest Iran: A Case Report.
Niemann-Pick Diseases
New tools for the study of Niemann-Pick disease: analogues of natural substrate and Epstein-Barr virus-transformed lymphoid cell lines.
Niemann-Pick Diseases
Niemann Pick Disease type A in Israeli Arabs: 677delT, a common novel single mutation. Mutations in brief no. 161. Online.
Niemann-Pick Diseases
Niemann Pick disease: presence of the magnesium-dependent sphingomyelinase in brain of the infantile form of the disease.
Niemann-Pick Diseases
Niemann-Pick disease (variation in the sphingomyelinase deficient group). Neurovisceral phenotype (A) with an abnormally protracted clinical course and variable expression of neurological symptomatology in three siblings.
Niemann-Pick Diseases
Niemann-Pick disease A or B in four pediatric patients and SMPD1 mutation carrier frequency in the Mexican population.
Niemann-Pick Diseases
Niemann-Pick disease and juvenile xanthogranuloma. Are they related?
Niemann-Pick Diseases
Niemann-Pick disease experimental model: sphingomyelinase reduction induced by AY-9944.
Niemann-Pick Diseases
Niemann-Pick disease in a poodle dog.
Niemann-Pick Diseases
Niemann-Pick disease type A and B are clinically but also enzymatically heterogeneous: pitfall in the laboratory diagnosis of sphingomyelinase deficiency associated with the mutation Q292 K.
Niemann-Pick Diseases
Niemann-Pick disease type B: an unusual clinical presentation with multiple vertebral fractures.
Niemann-Pick Diseases
Niemann-Pick disease type B: first-trimester prenatal diagnosis on chorionic villi and biochemical study of a foetus at 12 weeks of development.
Niemann-Pick Diseases
Niemann-Pick disease type B: prenatal diagnosis and enzymatic and chemical studies on fetal brain and liver.
Niemann-Pick Diseases
Niemann-Pick disease type C presenting as neonatal hepatitis: report of one case.
Niemann-Pick Diseases
Niemann-Pick disease type C: an update.
Niemann-Pick Diseases
Niemann-Pick disease type D: lipid analyses and studies on sphingomyelinases.
Niemann-Pick Diseases
Niemann-Pick disease type-B: a unique case report with compound heterozygosity and complicated lipid management.
Niemann-Pick Diseases
Niemann-Pick Disease versus acid sphingomyelinase deficiency.
Niemann-Pick Diseases
Niemann-Pick disease, type C and Roscoe Brady.
Niemann-Pick Diseases
Niemann-Pick disease, Type C: evidence for the deficiency of an activating factor stimulating sphingomyelin and glucocerebroside degradation.
Niemann-Pick Diseases
Niemann-Pick disease.
Niemann-Pick Diseases
Niemann-Pick disease: a frequent missense mutation in the acid sphingomyelinase gene of Ashkenazi Jewish type A and B patients.
Niemann-Pick Diseases
Niemann-Pick disease: coupling and uncoupling of inhibited sphingomyelinase activity and exogenous cholesterol esterification in fibroblasts by ionophore treatment.
Niemann-Pick Diseases
Niemann-Pick disease: mutation update, genotype/phenotype correlations, and prospects for genetic testing.
Niemann-Pick Diseases
Niemann-Pick disease: prenatal diagnoses and studies of sphingomyelinase activities.
Niemann-Pick Diseases
Niemann-Pick diseases.
Niemann-Pick Diseases
Niemann-Pick human lymphoblasts are resistant to phthalocyanine 4-photodynamic therapy-induced apoptosis.
Niemann-Pick Diseases
Niemann-Pick type B disease. Identification of a single codon deletion in the acid sphingomyelinase gene and genotype/phenotype correlations in type A and B patients.
Niemann-Pick Diseases
Niemann-Pick's disease. Clinical, biochemical and ultrastructural findings in a case of the infantile form.
Niemann-Pick Diseases
NiemannPick disease: own observations and new therapeutic options
Niemann-Pick Diseases
Novel first-dose adverse drug reactions during a phase I trial of olipudase alfa (recombinant human acid sphingomyelinase) in adults with Niemann-Pick disease type B (acid sphingomyelinase deficiency).
Niemann-Pick Diseases
Novel mutations in the SMPD1 gene in Jordanian children with Acid sphingomyelinase deficiency (Niemann-Pick types A and B).
Niemann-Pick Diseases
Ophthalmologic manifestations of type B Niemann-Pick diseases.
Niemann-Pick Diseases
Optimization of a histopathological biomarker for sphingomyelin accumulation in Acid sphingomyelinase deficiency.
Niemann-Pick Diseases
Orthotopic liver transplantation in two adults with Niemann-Pick and Gaucher's diseases: implications for the treatment of inherited metabolic disease.
Niemann-Pick Diseases
Pathogenic Compound Heterozygous Mutations in a Mexican Mestizo Patient with Niemann-Pick Disease Type B.
Niemann-Pick Diseases
Pathology of visceral organs and bone marrow in an acid sphingomyelinase deficient knock-out mouse line, mimicking human Niemann-Pick disease type A. A light and electron microscopic study.
Niemann-Pick Diseases
Peripheral neuropathy in type A Niemann-Pick disease. A morphological study.
Niemann-Pick Diseases
Pharmacological reversion of sphingomyelin-induced dendritic spine anomalies in a Niemann Pick disease type A mouse model.
Niemann-Pick Diseases
Phosphatidylinositol-3,5-Bisphosphate is a potent and selective inhibitor of acid sphingomyelinase.
Niemann-Pick Diseases
Preimplantation diagnosis of a lysosomal storage disorder by in situ enzymatic activity: 'proof of principle' in acid sphingomyelinase-deficient mice.
Niemann-Pick Diseases
Preimplantation genetic diagnosis for Niemann-Pick disease type B.
Niemann-Pick Diseases
Prenatal diagnosis and fetal pathology of Niemann-Pick disease.
Niemann-Pick Diseases
Prenatal diagnosis of Gaucher's and Niemann-Pick diseases. Assays of glucocerebrosidase and sphingomyelinase in tissue cultures using natural substrates.
Niemann-Pick Diseases
Prenatal diagnosis of Niemann-Pick disease type C.
Niemann-Pick Diseases
Prenatal diagnosis of Niemann-Pick diseases types A, B and C.
Niemann-Pick Diseases
Presence of immunoreactive material in Niemann-Pick type A placenta using anti-sphingomyelinase rabbit gammaglobulins.
Niemann-Pick Diseases
Prospective study of the natural history of chronic acid sphingomyelinase deficiency in children and adults: eleven years of observation.
Niemann-Pick Diseases
Pulmonary delivery of recombinant acid sphingomyelinase improves clearance of lysosomal sphingomyelin from the lungs of a murine model of Niemann-Pick disease.
Niemann-Pick Diseases
Purification and characterization of recombinant, human acid ceramidase. Catalytic reactions and interactions with acid sphingomyelinase.
Niemann-Pick Diseases
Quantitation of plasmatic lysosphingomyelin and lysosphingomyelin-509 for differential screening of Niemann-Pick A/B and C diseases.
Niemann-Pick Diseases
R542X mutation in SMPD1 gene: genetically novel mutation with phenotypic features intermediate between type A and type B Niemann-Pick disease.
Niemann-Pick Diseases
Rapid screening for lipid storage disorders using biochemical markers. Expert center data and review of the literature.
Niemann-Pick Diseases
Recombinant human acid sphingomyelinase as an adjuvant to sorafenib treatment of experimental liver cancer.
Niemann-Pick Diseases
Reduced cellular cholesterol efflux and low plasma high-density lipoprotein cholesterol in a patient with type B Niemann-Pick disease because of a novel SMPD-1 mutation.
Niemann-Pick Diseases
Regional assignment of the human acid sphingomyelinase gene (SMPD1) by PCR analysis of somatic cell hybrids and in situ hybridization to 11p15.1----p15.4.
Niemann-Pick Diseases
Regulation of the NPC2 protein-mediated cholesterol trafficking by membrane lipids.
Niemann-Pick Diseases
Replacement therapy for inherited enzyme deficiency: liver orthotopic transplantation in Niemann-Pick disease type A.
Niemann-Pick Diseases
Reproductive pathology and sperm physiology in acid sphingomyelinase-deficient mice.
Niemann-Pick Diseases
Resolution of tissue sphingomyelinase isoelectric profile in multiple components is extraction-dependent: evidence for a component defect in Niemann-Pick disease type C is spurious.
Niemann-Pick Diseases
Respiratory impairment in Niemann-Pick B disease: Two case reports and review for the pulmonologist.
Niemann-Pick Diseases
Retroviral-mediated transfer of the human acid sphingomyelinase cDNA: correction of the metabolic defect in cultured Niemann-Pick disease cells.
Niemann-Pick Diseases
Role of sphingomyelinases in neurological disorders.
Niemann-Pick Diseases
Roles and regulation of secretory and lysosomal acid sphingomyelinase.
Niemann-Pick Diseases
Roles and Regulation of Secretory and Lysosomal Acid Sphingomyelinase.
Niemann-Pick Diseases
Safety study of adeno-associated virus serotype 2-mediated human Acid sphingomyelinase expression in the nonhuman primate brain.
Niemann-Pick Diseases
Screening of 25 Italian patients with Niemann-Pick A reveals fourteen new mutations, one common and thirteen private, in SMPD1.
Niemann-Pick Diseases
Secretory sphingomyelinase in health and disease.
Niemann-Pick Diseases
Serum Zn(2+)-stimulated sphingomyelinase deficiency in type B Niemann-Pick disease.
Niemann-Pick Diseases
Seven novel acid sphingomyelinase gene mutations in Niemann-Pick type A and B patients.
Niemann-Pick Diseases
Seven novel mutations of the SMPD1 gene in four Chinese patients with Niemann-Pick disease type A and prenatal diagnosis for four fetuses.
Niemann-Pick Diseases
Signaling pathway for radiation-induced apoptosis in the lymphoblasts from neuronopathic (type A) and non-neuronopathic (type B) forms of Niemann-Pick disease.
Niemann-Pick Diseases
Skeletal manifestations in pediatric and adult patients with Niemann Pick disease type B.
Niemann-Pick Diseases
SMPD1 variants in Chinese Han patients with sporadic Parkinson's disease.
Niemann-Pick Diseases
Solving the secretory acid sphingomyelinase puzzle: Insights from lysosome-mediated parasite invasion and plasma membrane repair.
Niemann-Pick Diseases
Somatic cell hybridisation studies showing different gene mutations in Niemann-Pick variants.
Niemann-Pick Diseases
Spectrum of SMPD1 mutations in Asian-Indian patients with acid sphingomyelinase (ASM)-deficient Niemann-Pick disease.
Niemann-Pick Diseases
Sperm Abnormalities in Heterozygous Acid Sphingomyelinase Knockout Mice Reveal a Novel Approach for the Prevention of Genetic Diseases.
Niemann-Pick Diseases
Sperm abnormalities in heterozygous acid sphingomyelinase knockout mice reveal a novel approach for the prevention of genetic diseases.
Niemann-Pick Diseases
Sphingomyelin phosphodiesterase-1 (SMPD1) coding variants do not contribute to low levels of high-density lipoprotein cholesterol.
Niemann-Pick Diseases
Sphingomyelin storage in a patient with myoclonus epilepsy as a main clinical symptom -- a varient in Niemann-Pick disease type C.
Niemann-Pick Diseases
Sphingomyelinase activities in cultured skin fibroblasts from patients with Niemann-Pick Disease.
Niemann-Pick Diseases
Sphingomyelinase activities of various human tissues in control subjects and in Niemann-Pick disease - development and evaluation of a microprocedure.
Niemann-Pick Diseases
Sphingomyelinase activity levels in human peripheral blood leukocytes, using [3H]sphingomyelin as substrate: study of heterozygotes and homozygotes for Niemann-Pick disease variants.
Niemann-Pick Diseases
Sphingomyelinase and nonspecific phosphodiesterase activities in Epstein-Barr virus-transformed lymphoid cell lines from Niemann-Pick disease A, B and C.
Niemann-Pick Diseases
Sphingomyelinase defect in Niemann-Pick disease, type C, fibroblasts.
Niemann-Pick Diseases
Sphingomyelinase enzyme assay in Niemann-Pick disease.
Niemann-Pick Diseases
Sphingomyelinase in cultured skin fibroblasts from normal and Niemann-Pick type C patients.
Niemann-Pick Diseases
Sphingomyelinase in normal human spleens and in spleens from subjects with Niemann-Pick disease.
Niemann-Pick Diseases
Sphingomyelinase isozymes of human tissues: a phpothesis on enzymatic differentiation of the neuropathic and non-neuropathic forms of Niemann-Pick disease.
Niemann-Pick Diseases
Structural and functional analysis of the ASM p.Ala359Asp mutant that causes acid sphingomyelinase deficiency.
Niemann-Pick Diseases
Studies on pyrophosphate diesterase activity in cultured human fibroblasts: a deficiency in Niemann-Pick disease.
Niemann-Pick Diseases
Studies on sphingomyelinase activity in cultured cells and leucocytes.
Niemann-Pick Diseases
Studies on sphingomyelinase and beta-glucosidase activities in Niemann-Pick disease variants. Phosphodiesterase activities measured with natural and artificial substrates.
Niemann-Pick Diseases
Subclinical course of adult visceral Niemann-Pick type C1 disease. A rare or underdiagnosed disorder?
Niemann-Pick Diseases
Successful within-patient dose escalation of olipudase alfa in acid sphingomyelinase deficiency.
Niemann-Pick Diseases
Synaptic vesicle docking: sphingosine regulates syntaxin1 interaction with Munc18.
Niemann-Pick Diseases
Synthesis of pyrenesulfonylamido-sphingomyelin and its use as substrate for determining sphingomyelinase activity and diagnosing Niemann-Pick disease.
Niemann-Pick Diseases
Systemic lupus erythematosus occurring in a patient with Niemann-Pick type B disease.
Niemann-Pick Diseases
The Acid Sphingomyelinase Sequence Variant p.A487V Is Not Associated With Decreased Levels of Enzymatic Activity.
Niemann-Pick Diseases
The IL-1 receptor signaling pathway.
Niemann-Pick Diseases
The impact of biomarkers analysis in the diagnosis of Niemann-Pick C disease and acid sphingomyelinase deficiency.
Niemann-Pick Diseases
The natural history of type B Niemann-Pick disease: results from a 10-year longitudinal study.
Niemann-Pick Diseases
The pathogenesis and treatment of acid sphingomyelinase-deficient Niemann-Pick disease.
Niemann-Pick Diseases
The R608del mutation in the acid sphingomyelinase gene (SMPD1) is the most prevalent among patients from Gran Canaria Island with Niemann-Pick disease type B.
Niemann-Pick Diseases
The structure and catalytic mechanism of human sphingomyelin phosphodiesterase like 3a--an acid sphingomyelinase homologue with a novel nucleotide hydrolase activity.
Niemann-Pick Diseases
The unexpected role of acid sphingomyelinase in cell death and the pathophysiology of common diseases.
Niemann-Pick Diseases
Toward gene therapy for Niemann-Pick disease (NPD): separation of retrovirally corrected and noncorrected NPD fibroblasts using a novel fluorescent sphingomyelin.
Niemann-Pick Diseases
Transitory type of sphingomyelinase deficient Niemann-Pick disease: clinical and morphological studies and follow-up of two sisters.
Niemann-Pick Diseases
Treatment of sphingomyelinase deficiency by repeated implantations of amniotic epithelial cells.
Niemann-Pick Diseases
Two new mutations in the acid sphingomyelinase gene causing type a Niemann-pick disease: N389T and R441X.
Niemann-Pick Diseases
Two Siblings with Niemann-Pick Disease (NPD) Type B: Clinical Findings and Novel Mutations of the Acid Sphingomyelinase Gene.
Niemann-Pick Diseases
Type A Niemann-Pick disease: a frameshift mutation in the acid sphingomyelinase gene (fsP330) occurs in Ashkenazi Jewish patients.
Niemann-Pick Diseases
Unsuccessful treatment attempt: cord blood stem cell transplantation in a patient with Niemann-Pick disease type A.
Niemann-Pick Diseases
Uptake and intracellular degradation of fluorescent sphingomyelin by fibroblasts from normal individuals and a patient with Niemann-Pick disease.
Niemann-Pick Diseases
Uptake and metabolism of radioactively labeled sphingomyelin in cultured skin fibroblasts from controls and patients with Niemann-Pick disease and other lysosomal storage diseases.
Niemann-Pick Diseases
Zn2+-stimulated sphingomyelinase is secreted by many cell types and is a product of the acid sphingomyelinase gene.
Niemann-Pick Diseases
[A Case of a Korean Adult Affected by Type B Niemann-Pick Disease: Secondary Sea-blue Histiocytosis and Molecular Characterization.]
Niemann-Pick Diseases
[A case of type C Niemann-Pick disease]
Niemann-Pick Diseases
[A female patient with splenomegaly, interstitial pneumopathy and giant foam cells in bone marrow]
Niemann-Pick Diseases
[A novel mutation in two spanish children with the Niemann Pick disease: Description of genotype, acid sphingomyelinase activity, phenotype and review].
Niemann-Pick Diseases
[Activators for sphingohydrolases and the nature of the sphingomyelinase deficiency in Niemann-Pick disease types A, B and C (author's transl)]
Niemann-Pick Diseases
[Adult Niemann-Pick disease: a 26 years follow-up. Report of a case with isolated visceral involvement, excess of tissue sphingomyelin, and deficient sphingomyelinase activity (author's transl)]
Niemann-Pick Diseases
[Bone marrow manifestation of Niemann-Pick disease. A review of histiocytic proliferations of the bone marrow]
Niemann-Pick Diseases
[Interstitial pneumopathy revealing type B Niemann Pick disease in an adult]
Niemann-Pick Diseases
[Niemann-Pick disease revealed late by miliary tuberculosis: diagnosis by leukocyte determination of sphingomyelinase deficiency]
Niemann-Pick Diseases
[Niemann-Pick disease type B identified following an episode of bronchopneumonia]
Niemann-Pick Diseases
[Niemann-Pick disease type B: An enzymatically confirmed case with unexpected retinal involvement (author's transl)]
Niemann-Pick Diseases
[Niemann-Pick disease type C (subacute neurovisceral lipidosis). Problems of altered sphingomyelinase activity in the brain (author's transl)]
Niemann-Pick Diseases
[Niemann-Pick disease types A and B]
Niemann-Pick Diseases
[Niemann-Pick disease [type A and B] (acid sphingomyelinase deficiencies)]
Niemann-Pick Diseases
[Sphingomyelinase activity in a patient with Niemann-Pick disease]
Niemann-Pick Diseases
[Type B Niemann Pick disease: clinical description of three patients in a same family]
Non-alcoholic Fatty Liver Disease
Amitriptyline inhibits nonalcoholic steatohepatitis and atherosclerosis induced by high-fat diet and LPS through modulation of sphingolipid metabolism.
Non-alcoholic Fatty Liver Disease
High fat diet induced hepatic steatosis and insulin resistance: Role of dysregulated ceramide metabolism.
Non-alcoholic Fatty Liver Disease
Macrophage-derived thrombospondin 1 promotes obesity-associated non-alcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
Serum acid sphingomyelinase is upregulated in chronic hepatitis C infection and non alcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
Sphingomyelinases and Liver Diseases.
Obesity
A high-throughput sphingomyelinase assay using natural substrate.
Obesity
Altered adipose and plasma sphingolipid metabolism in obesity: a potential mechanism for cardiovascular and metabolic risk.
Obesity
Genome Regulation and Gene Interaction Networks Inferred From Muscle Transcriptome Underlying Feed Efficiency in Pigs.
Obesity
Genome-Wide DNA Methylation Profiles of Phlegm-Dampness Constitution.
Obesity
Pioglitazone time-dependently reduces tumour necrosis factor-alpha level in muscle and improves metabolic abnormalities in Wistar fatty rats.
Obesity
Serum sphingolipids and inflammatory mediators in adolescents at risk for metabolic syndrome.
Obesity
Sortilin deficiency improves the metabolic phenotype and reduces hepatic steatosis of mice subjected to diet-induced obesity.
Obesity
Sphingomyelinases and Liver Diseases.
Ocular Hypertension
Evidence for ceramide induced cytotoxicity in retinal ganglion cells.
Oligodendroglioma
Acid sphingomyelinase and inhibition by phosphate ion: role of inhibition by phosphatidyl-myo-inositol 3,4,5-triphosphate in oligodendrocyte cell signaling.
Oligodendroglioma
Differential regulation of sphingomyelin synthesis and catabolism in oligodendrocytes and neurons.
Oligodendroglioma
Regulation of sphingomyelinases in cells of the oligodendrocyte lineage.
Oligodendroglioma
The hyaluronic acid inhibitor 4-methylumbelliferone is an NSMase2 activator-role of Ceramide in MU anti-tumor activity.
Osteogenesis Imperfecta
Hyaluronan synthase-2 upregulation protects smpd3-deficient fibroblasts against cell death induced by nutrient deprivation, but not against apoptosis evoked by oxidized LDL.
Osteogenesis Imperfecta
Inducible transient expression of Smpd3 prevents early lethality in fro/fro mice.
Osteogenesis Imperfecta
Local regulation of tooth mineralization by sphingomyelin phosphodiesterase 3.
Osteogenesis Imperfecta
Neutral Sphingomyelinase 2 (SMPD3) Deficiency in Mice Causes Chondrodysplasia with Unimpaired Skeletal Mineralization.
Osteogenesis Imperfecta
Neutral sphingomyelinase 2 deficiency is associated with lung anomalies similar to emphysema.
Osteogenesis Imperfecta
Smpd3 Expression in both Chondrocytes and Osteoblasts Is Required for Normal Endochondral Bone Development.
Osteomyelitis
Capsule expression and genotypic differences among Staphylococcus aureus isolates from patients with chronic or acute osteomyelitis.
Osteomyelitis
The role of antibodies against alpha-toxin and teichoic acid in the diagnosis of staphylococcal infections.
Osteoporosis
Neutral Sphingomyelinase 2 (SMPD3) Deficiency in Mice Causes Chondrodysplasia with Unimpaired Skeletal Mineralization.
Osteosarcoma
Lactosylceramide is required in apoptosis induced by N-Smase.
Osteosarcoma
Mutations in the neutral sphingomyelinase gene SMPD3 implicate the ceramide pathway in human leukemias.
Ototoxicity
Impact of sphingolipid mediators on determination of cochlear survival in ototoxicity.
Ovarian Neoplasms
A novel cisplatin mediated apoptosis pathway is associated with acid sphingomyelinase and FAS proapoptotic protein activation in ovarian cancer.
Ovarian Neoplasms
Acid sphingomyelinase, a novel negative biomarker of ovarian cancer.
Pancreatic Neoplasms
?-Tocotrienol induces apoptosis in pancreatic cancer cells by upregulation of ceramide synthesis and modulation of sphingolipid transport.
Pancreatitis
Effect of staphylococcal alpha-toxin pancreatitis on glucose tolerance in the dog.
Paralysis
[Lipidosis with vertical gaze palsy, macular degeneration, and sphingomyelinase deficiency]
Parasitemia
Influence of amitriptyline on eryptosis, parasitemia and survival of Plasmodium berghei-infected mice.
Parasitemia
T Cell-Specific Overexpression of Acid Sphingomyelinase Results in Elevated T Cell Activation and Reduced Parasitemia During Plasmodium yoelii Infection.
Parkinson Disease
A rare lysosomal enzyme gene SMPD1 variant (p.R591C) associates with Parkinson's disease.
Parkinson Disease
Association study between SMPD1 p.L302P and sporadic Parkinson's disease in ethnic Chinese population.
Parkinson Disease
Chromosomal microarray and whole-exome sequence analysis in Taiwanese patients with autism spectrum disorder.
Parkinson Disease
Correction to: Pharmacological inhibition of nSMase2 reduces brain exosome release and ?-synuclein pathology in a Parkinson's disease model.
Parkinson Disease
Excessive burden of lysosomal storage disorder gene variants in Parkinson's disease.
Parkinson Disease
Genetic convergence of Parkinson's disease and lysosomal storage disorders.
Parkinson Disease
Genetic risk factors in Finnish patients with Parkinson's disease.
Parkinson Disease
Interactions between neural membrane glycerophospholipid and sphingolipid mediators: a recipe for neural cell survival or suicide.
Parkinson Disease
LRRK2, GBA and SMPD1 Founder Mutations and Parkinson's Disease in Ashkenazi Jews.
Parkinson Disease
Neutral Sphingomyelinase Behaviour in Hippocampus Neuroinflammation of MPTP-Induced Mouse Model of Parkinson's Disease and in Embryonic Hippocampal Cells.
Parkinson Disease
Pharmacological inhibition of nSMase2 reduces brain exosome release and ?-synuclein pathology in a Parkinson's disease model.
Parkinson Disease
SMPD1 mutations and Parkinson disease.
Parkinson Disease
SMPD1 mutations, activity, and ?-synuclein accumulation in Parkinson's disease.
Parkinson Disease
SMPD1 variants do not have a major role in rapid eye movement sleep behavior disorder.
Parkinson Disease
SMPD1 variants in Chinese Han patients with sporadic Parkinson's disease.
Parkinson Disease
Systematic Genetic Analysis of the SMPD1 Gene in Chinese Patients with Parkinson's Disease.
Parkinson Disease
The contribution of Niemann-Pick SMPD1 mutations to Parkinson disease in Ashkenazi Jews.
Parkinson Disease
The emerging role of SMPD1 mutations in Parkinson's disease: Implications for future studies.
Parkinson Disease
The p.L302P mutation in the lysosomal enzyme gene SMPD1 is a risk factor for Parkinson disease.
Parkinson Disease
[Mutation del 1,02kb in the CLN3 gene and extrapyramidal syndrome].
Periodontitis
Acid sphingomyelinase deficiency exacerbates LPS-induced experimental periodontitis.
Peritonitis
Role of antibodies against fibronectin-, collagen-binding proteins and alphatoxin in experimental Staphylococcus aureus peritonitis and septicaemia in neutropenic mice.
Peritonitis
The urine from patients with peritonitis as a rich source for purifying human acid sphingomyelinase and other lysosomal enzymes.
Pheochromocytoma
Alpha-toxin permeabilized rat pheochromocytoma cells: a new approach to investigate stimulus-secretion coupling.
Pheochromocytoma
Antioxidant and pro-oxidant capacity of catecholamines and related compounds. Effects of hydrogen peroxide on glutathione and sphingomyelinase activity in pheochromocytoma PC12 cells: potential relevance to age-related diseases.
Pheochromocytoma
CrmA protects against apoptosis and ceramide formation in PC12 cells.
Pheochromocytoma
Further characterization of dopamine release by permeabilized PC12 cells.
Pheochromocytoma
Melatonin Acts as an Antidepressant by Inhibition of the Acid Sphingomyelinase/Ceramide System.
Pheochromocytoma
Minimal requirements for exocytosis. A study using PC 12 cells permeabilized with staphylococcal alpha-toxin.
Pheochromocytoma
Staphylococcus aureus alpha-toxin activates phospholipases and induces a Ca2+ influx in PC12 cells.
Photosensitivity Disorders
Fumonisin B1 does not prevent apoptosis in A431 human epidermoid carcinoma cells after photosensitization with a silicon phthalocyanine.
Pick Disease of the Brain
Astrocytic ceramide as possible indicator of neuroinflammation.
Pneumonia
Acid sphingomyelinase deficiency attenuates bleomycin-induced lung inflammation and fibrosis in mice.
Pneumonia
Acid Sphingomyelinase Inhibition in Stored Erythrocytes Reduces Transfusion-Associated Lung Inflammation.
Pneumonia
Alpha-toxin damages the air-blood barrier of the lung in a rat model of Staphylococcus aureus-induced pneumonia.
Pneumonia
Alpha-toxin facilitates the generation of CXC chemokine gradients and stimulates neutrophil homing in Staphylococcus aureus pneumonia.
Pneumonia
Altered Macrophage Function Associated with Crystalline Lung Inflammation in Acid Sphingomyelinase Deficiency.
Pneumonia
Ceramide in Pseudomonas aeruginosa infections and cystic fibrosis.
Pneumonia
Ceramide-1-phosphate inhibits cigarette smoke-induced airway inflammation.
Pneumonia
Decreased plasma phospholipid concentrations and increased acid sphingomyelinase activity are accurate biomarkers for community-acquired pneumonia.
Pneumonia
Group B streptococcal beta-hemolysin promotes injury of lung microvascular endothelial cells.
Pneumonia
Linezolid Attenuates Lethal Lung Damage during Postinfluenza Methicillin-Resistant Staphylococcus aureus Pneumonia.
Pneumonia
MEDI4893* Promotes Survival and Extends the Antibiotic Treatment Window in a Staphylococcus aureus Immunocompromised Pneumonia Model.
Pneumonia
Staphylococcus aureus alpha-toxin mediates general and cell type-specific changes in metabolite concentrations of immortalized human airway epithelial cells.
Pneumonia
[Detection of Staphylococcus aureus and Staphylococcus epidermis species specific antigens and antibodies to alpha-toxin in the blood of patients with pneumonia]
Pneumonia, Necrotizing
Effects of Tedizolid Phosphate on Survival Outcomes and Suppression of Production of Staphylococcal Toxins in a Rabbit Model of Methicillin-Resistant Staphylococcus aureus Necrotizing Pneumonia.
Pneumonia, Staphylococcal
Alpha-toxin facilitates the generation of CXC chemokine gradients and stimulates neutrophil homing in Staphylococcus aureus pneumonia.
Prader-Willi Syndrome
Malignant fibrous histiocytoma-pleomorphic sarcoma, NOS gene expression, histology, and clinical course. A pilot study.
Pre-Eclampsia
Ceramide-Induced Lysosomal Biogenesis and Exocytosis in Early-Onset Preeclampsia Promotes Exosomal Release of SMPD1 Causing Endothelial Dysfunction.
Pre-Eclampsia
Disruption of sphingolipid metabolism augments ceramide-induced autophagy in preeclampsia.
Pre-Eclampsia
Epitranscriptomic profiling in human placenta: N6-methyladenosine modification at the 5'-untranslated region is related to fetal growth and preeclampsia.
Pre-Eclampsia
Increased secretory sphingomyelinase activity in the first trimester of pregnancy in women later developing preeclampsia: a nested case-control study.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Why high cholesterol levels help hematological malignancies: role of nuclear lipid microdomains.
Pregnancy, High-Risk
Prenatal diagnosis and fetal pathology of Niemann-Pick disease.
Prostatic Neoplasms
Caveolin-1 regulates the ASMase/ceramide-mediated radiation response of endothelial cells in the context of tumor-stroma interactions.
Prostatic Neoplasms
Phosphodiesterase SMPDL3B Gene Expression as Independent Outcome Prediction Marker in Localized Prostate Cancer.
Proteinuria
Barley-ß-glucans reduce systemic inflammation, renal injury and aortic calcification through ADAM17 and neutral-sphingomyelinase2 inhibition.
Proteinuria
Podocyte pathology and nephropathy - sphingolipids in glomerular diseases.
Proteinuria
Rituximab protects podocytes and exerts anti-proteinuric effects in rat adriamycin-induced nephropathy independent of B-lymphocytes.
Proteinuria
Rituximab Treatment Prevents the Early Development of Proteinuria following Pig-to-Baboon Xeno-Kidney Transplantation.
Proteinuria
Sphingomyelinase-Like Phosphodiesterase 3b Expression Levels Determine Podocyte Injury Phenotypes in Glomerular Disease.
Pseudomonas Infections
Defective Acid Sphingomyelinase Pathway with Pseudomonas aeruginosa Infection in Cystic Fibrosis.
Psoriasis
Staphylococcal toxins and protein A differentially induce cytotoxicity and release of tumor necrosis factor-alpha from human keratinocytes.
Psoriasis
The Spectrum of Mild to Severe Psoriasis Vulgaris Is Defined by a Common Activation of IL-17 Pathway Genes, but with Key Differences in Immune Regulatory Genes.
Puberty, Delayed
Neutral sphingomyelinase 2 (smpd3) in the control of postnatal growth and development.
Pulmonary Disease, Chronic Obstructive
Bacterial Sphingomyelinase is a State-Dependent Inhibitor of the Cystic Fibrosis Transmembrane conductance Regulator (CFTR).
Pulmonary Disease, Chronic Obstructive
Decreased plasma phospholipid concentrations and increased acid sphingomyelinase activity are accurate biomarkers for community-acquired pneumonia.
Pulmonary Disease, Chronic Obstructive
Epithelial IL-33 appropriates exosome trafficking for secretion in chronic airway disease.
Pulmonary Disease, Chronic Obstructive
Neutral sphingomyelinase-2, acid sphingomyelinase, and ceramide levels in COPD patients compared to controls.
Pulmonary Disease, Chronic Obstructive
Structural and functional characterization of endothelial microparticles released by cigarette smoke.
Pulmonary Edema
Group B streptococcal beta-hemolysin promotes injury of lung microvascular endothelial cells.
Pulmonary Edema
PAF-mediated pulmonary edema: a new role for acid sphingomyelinase and ceramide.
Pulmonary Fibrosis
Acid sphingomyelinase deficiency attenuates bleomycin-induced lung inflammation and fibrosis in mice.
Pulmonary Fibrosis
Ceramide mediates lung fibrosis in cystic fibrosis.
Pulmonary Fibrosis
[Acid sphingomyelinase deficiency and spleen trauma: Splenectomy or not splenectomy?]
Purpura, Thrombocytopenic, Idiopathic
Splenic histiocytosis in idiopathic thrombocytopenic purpura: a relative sphingomyelinase deficiency?
Rectal Neoplasms
Reduction in alkaline sphingomyelinase in colorectal tumorigenesis is not related to the APC gene mutation.
REM Sleep Behavior Disorder
SMPD1 variants do not have a major role in rapid eye movement sleep behavior disorder.
Renal Insufficiency
Partial sphingomyelinase deficiency with sea-blue histiocytosis and neurovisceral dysfunction.
Renal Insufficiency
[Functional, histological, biochemical renal modifications. Comparative study of dibekacin, gentamicin, tobramycin, netilmicin and amikacin]
Reperfusion Injury
Critical role of acidic sphingomyelinase in murine hepatic ischemia-reperfusion injury.
Reperfusion Injury
Homozygous Smpd1 deficiency aggravates brain ischemia/ reperfusion injury by mechanisms involving polymorphonuclear neutrophils, whereas heterozygous Smpd1 deficiency protects against mild focal cerebral ischemia.
Reperfusion Injury
Inhibition of neutral sphingomyelinase decreases arachidonic acid mediated inflammation in liver ischemia-reperfusion injury.
Reperfusion Injury
Inhibition of neutral sphingomyelinase decreases elevated levels of nitrative and oxidative stress markers in liver ischemia-reperfusion injury.
Reperfusion Injury
Neutral sphingomyelinase inhibition alleviates apoptosis, but not ER stress, in liver ischemia-reperfusion injury.
Reperfusion Injury
Raft ceramide in molecular medicine.
Reperfusion Injury
Sphingomyelinase and ceramide analogs induce vasoconstriction and leukocyte-endothelial interactions in cerebral venules in the intact rat brain: Insight into mechanisms and possible relation to brain injury and stroke.
Reperfusion Injury
Sphingomyelinases: their regulation and roles in cardiovascular pathophysiology.
Reperfusion Injury
The Roles of Neutral Sphingomyelinases in Neurological Pathologies.
Respiratory Insufficiency
Staphylococcal alpha-toxin-induced vascular leakage in isolated perfused rabbit lungs.
Respiratory Insufficiency
Topical application of phosphatidyl-inositol-3,5-bisphosphate for acute lung injury in neonatal swine.
Retinal Degeneration
Lack of Acid Sphingomyelinase Induces Age-Related Retinal Degeneration.
Retinitis Pigmentosa
The plasma peptides of Alzheimer's disease.
Retinoblastoma
Neutral sphingomyelinase-2 mediates growth arrest by retinoic acid through modulation of ribosomal S6 kinase.
Retinoblastoma
Role for mammalian neutral sphingomyelinase 2 in confluence-induced growth arrest of MCF7 cells.
Rhabdomyosarcoma
Ceramide-induced G2 arrest in rhabdomyosarcoma (RMS) cells requires p21Cip1/Waf1 induction and is prevented by MDM2 overexpression.
Rubella
Comparative study of immune status to infectious agents in elderly patients with multiple myeloma, Waldenstrom's macroglobulinemia, and monoclonal gammopathy of undetermined significance.
Schistosomiasis
In vitro and in vivo activities of arachidonic acid against Schistosoma mansoni and Schistosoma haematobium.
Schistosomiasis
Novel therapeutic and prevention approaches for schistosomiasis: review.
Sea-Blue Histiocyte Syndrome
Biochemical, genetic and ultrastructural study of a family with the sea-blue histiocyte syndrome/chronic non-neuronopathic Niemann-Pick disease.
Sea-Blue Histiocyte Syndrome
Partial sphingomyelinase deficiency with sea-blue histiocytosis and neurovisceral dysfunction.
Sea-Blue Histiocyte Syndrome
Sphingomyelinase activity levels in human peripheral blood leukocytes, using [3H]sphingomyelin as substrate: study of heterozygotes and homozygotes for Niemann-Pick disease variants.
Seizures
A novel non-transcriptional pathway mediates the proconvulsive effects of interleukin-1beta.
Seizures
Expression profiles of hippocampal regenerative sprouting-related genes and their regulation by E-64d in a developmental rat model of penicillin-induced recurrent epilepticus.
Seizures
Long-term expression of metabolism-associated genes in the rat hippocampus following recurrent neonatal seizures and its regulation by melatonin.
Seizures
Staphylococcal alpha toxin induced changes in the electroencephalogram of the rat.
Sepsis
A novel visible range FRET probe for monitoring acid sphingomyelinase activity in living cells.
Sepsis
Acid Sphingomyelinase Inhibition Prevents Development of Sepsis Sequelae in the Murine Liver.
Sepsis
Acid sphingomyelinase inhibition protects mice from lung edema and lethal Staphylococcus aureus sepsis.
Sepsis
Acid Sphingomyelinase Inhibition Stabilizes Hepatic Ceramide Content and Improves Hepatic Biotransformation Capacity in a Murine Model of Polymicrobial Sepsis.
Sepsis
Acid sphingomyelinase promotes endothelial stress response in systemic inflammation and sepsis.
Sepsis
Activation of acid sphingomyelinase and its inhibition by the nitric oxide/cyclic guanosine 3',5'-monophosphate pathway: key events in Escherichia coli-elicited apoptosis of dendritic cells.
Sepsis
Adjustment of Dysregulated Ceramide Metabolism in a Murine Model of Sepsis-Induced Cardiac Dysfunction.
Sepsis
Alternative splicing of SMPD1 in human sepsis.
Sepsis
APOPTOSIS CONTRIBUTES TO SEPTIC CARDIOMYOPATHY AND IS IMPROVED BY SIMVASTATIN THERAPY.
Sepsis
Apoptosis contributes to septic cardiomyopathy and is improved by simvastatin therapy.
Sepsis
Bacillus cereus sphingomyelinase recognizes ganglioside GM3.
Sepsis
Clostridium septicum myonecrosis presenting as a parapharyngeal abscess in a patient with aplastic anemia.
Sepsis
Decreased plasma phospholipid concentrations and increased acid sphingomyelinase activity are accurate biomarkers for community-acquired pneumonia.
Sepsis
Group B streptococcal beta-hemolysin induces mortality and liver injury in experimental sepsis.
Sepsis
Hyperresponsiveness of mice deficient in plasma-secreted sphingomyelinase reveals its pivotal role in early phase of host response.
Sepsis
Multimechanistic Monoclonal Antibodies (MAbs) Targeting Staphylococcus aureus Alpha-Toxin and Clumping Factor A: Activity and Efficacy Comparisons of a MAb Combination and an Engineered Bispecific Antibody Approach.
Sepsis
Programmed cellular necrosis mediated by the pore-forming alpha-toxin from Clostridium septicum.
Sepsis
Reevaluation of Lung Injury in TNF-Induced Shock: The Role of the Acid Sphingomyelinase.
Sepsis
Role of acid sphingomyelinase and IL-6 as mediators of endotoxin-induced pulmonary vascular dysfunction.
Sepsis
Role of increased sphingomyelinase activity in apoptosis and organ failure of patients with severe sepsis.
Sepsis
Role of sphingomyelinase in infectious diseases caused by Bacillus cereus.
Sepsis
Sphingomyelinase stimulates oxidant signaling to weaken skeletal muscle and promote fatigue.
Sepsis
Staphylococcus aureus ?-Toxin Mutants Are Defective in Biofilm Ligase and Sphingomyelinase Activity, and Causation of Infective Endocarditis/Sepsis.
Sepsis
Staphylococcus aureus ?-toxin Production is Common in Strains with the ?-toxin Gene Inactivated by Bacteriophage.
Sepsis
The role of antibodies against alpha-toxin and teichoic acid in the diagnosis of staphylococcal infections.
Sepsis
The role of sphingolipids in respiratory disease.
Sepsis
[Effect of lincomycin and staphylococcal vaccine on the course of experimental staphylococcal sepsis]
Severe Acute Respiratory Syndrome
Differential role of sphingomyelin in influenza virus, rhinovirus and SARS-CoV-2 infection of Calu-3 cells.
Severe Acute Respiratory Syndrome
Pharmacological Inhibition of Acid Sphingomyelinase Prevents Uptake of SARS-CoV-2 by Epithelial Cells.
Shock, Septic
ADRENOMEDULLIN REDUCES INTESTINAL EPITHELIAL PERMEABILITY IN VIVO AND IN VITRO.
Shock, Septic
Antibody levels against eleven Staphylococcus aureus antigens in a healthy population.
Shock, Septic
Cloning, characterization, and sequencing of an accessory gene regulator (agr) in Staphylococcus aureus.
Shock, Septic
Clostridial glucosylating toxins enter cells via clathrin-mediated endocytosis.
Shock, Septic
Cryptic alpha-toxin gene in toxic shock syndrome and septicaemia strains of Staphylococcus aureus.
Shock, Septic
Cytolysins augment superantigen penetration of stratified mucosa.
Shock, Septic
Geographical variation in the presence of genes encoding superantigenic exotoxins and beta-hemolysin among Staphylococcus aureus isolated from bovine mastitis in Europe and USA.
Shock, Septic
IgG4 subclass-specific responses to Staphylococcus aureus antigens shed new light on host-pathogen interaction.
Shock, Septic
Rapid isolation and identification of staphylococcal exoproteins by reverse phase capillary high performance liquid chromatography-electrospray ionization mass spectrometry.
Shock, Septic
Reduction in Staphylococcus aureus Growth and Exotoxin Production and in Vaginal Interleukin 8 Levels Due to Glycerol Monolaurate in Tampons.
Shock, Septic
Staphylococcal alpha-toxin provokes coronary vasoconstriction and loss in myocardial contractility in perfused rat hearts: role of thromboxane generation.
Shock, Septic
Staphylococcal toxins and protein A differentially induce cytotoxicity and release of tumor necrosis factor-alpha from human keratinocytes.
Shock, Septic
Synergism of Candida albicans and delta toxin producing Staphylococcus aureus on mouse mortality and morbidity: protection by indomethacin.
Shock, Septic
The role of virulence factors in the outcome of staphylococcal peritonitis in CAPD patients.
Shwartzman Phenomenon
Different pathways leading to cutaneous leukocytoclastic vasculitis in mice.
Sinusitis
Effects of beta-toxin of Staphylococcus aureus on ciliary activity of nasal epithelial cells.
Small Cell Lung Carcinoma
Synchronous Bilateral Lung Cancer With Discordant Histology.
Soft Tissue Infections
Anti-alpha-toxin monoclonal antibody and antibiotic combination therapy improves disease outcome and accelerates healing in a Staphylococcus aureus dermonecrosis model.
Sphingolipidoses
A novel association between angiokeratoma corporis diffusum and acid sphingomyelinase deficiency.
Sphingolipidoses
A novel SMPD1 mutation in two Chinese sibling patients with type B Niemann-Pick disease.
Sphingolipidoses
Apoptosis and signalling in acid sphingomyelinase deficient cells.
Sphingolipidoses
My journey into the world of sphingolipids and sphingolipidoses.
sphingomyelin phosphodiesterase deficiency
A family with visceral course of Niemann-Pick disease, macular halo syndrome and low sphingomyelin degradation rate.
sphingomyelin phosphodiesterase deficiency
A new variant of sphingomyelinase deficiency (Niemann-Pick): visceromegaly, minimal neurological lesions and low in vivo degradation rate of sphingomyelin.
sphingomyelin phosphodiesterase deficiency
A novel association between angiokeratoma corporis diffusum and acid sphingomyelinase deficiency.
sphingomyelin phosphodiesterase deficiency
AAV8-mediated hepatic expression of acid sphingomyelinase corrects the metabolic defect in the visceral organs of a mouse model of Niemann-Pick disease.
sphingomyelin phosphodiesterase deficiency
Abrogation of early apoptosis does not alter late inhibition of hippocampal neurogenesis after irradiation.
sphingomyelin phosphodiesterase deficiency
Acid sphingomyelinase (aSMase) deficiency leads to abnormal microglia behavior and disturbed retinal function.
sphingomyelin phosphodiesterase deficiency
Acid sphingomyelinase deficiency (Niemann?Pick disease Type B) as an inflammatory disease.
sphingomyelin phosphodiesterase deficiency
Acid Sphingomyelinase Deficiency Ameliorates Farber Disease.
sphingomyelin phosphodiesterase deficiency
Acid sphingomyelinase deficiency attenuates bleomycin-induced lung inflammation and fibrosis in mice.
sphingomyelin phosphodiesterase deficiency
Acid sphingomyelinase deficiency contributes to resistance of scleroderma fibroblasts to Fas-mediated apoptosis.
sphingomyelin phosphodiesterase deficiency
Acid sphingomyelinase deficiency does not protect from graft-versus-host disease in transplant recipients with Niemann-Pick disease.
sphingomyelin phosphodiesterase deficiency
Acid sphingomyelinase deficiency enhances myelin repair after acute and chronic demyelination.
sphingomyelin phosphodiesterase deficiency
Acid sphingomyelinase deficiency exacerbates LPS-induced experimental periodontitis.
sphingomyelin phosphodiesterase deficiency
Acid sphingomyelinase deficiency in Beckwith Wiedemann syndrome.
sphingomyelin phosphodiesterase deficiency
Acid sphingomyelinase deficiency in Western diet-fed mice protects against adipocyte hypertrophy and diet-induced liver steatosis.
sphingomyelin phosphodiesterase deficiency
Acid sphingomyelinase deficiency increases susceptibility to fatal alphavirus encephalomyelitis.
sphingomyelin phosphodiesterase deficiency
Acid Sphingomyelinase Deficiency Prevents Diet-induced Hepatic Triacylglycerol Accumulation and Hyperglycemia in Mice.
sphingomyelin phosphodiesterase deficiency
Acid sphingomyelinase deficiency protects from cisplatin-induced gastrointestinal damage.
sphingomyelin phosphodiesterase deficiency
Acid sphingomyelinase deficiency protects mitochondria and improves function recovery after brain injury.
sphingomyelin phosphodiesterase deficiency
Acid sphingomyelinase deficiency. Phenotype variability with prevalence of intermediate phenotype in a series of twenty-five Czech and Slovak patients. A multi-approach study.
sphingomyelin phosphodiesterase deficiency
Acid sphingomyelinase deficiency: Cardiac dysfunction and characteristic findings of the coronary arteries.
sphingomyelin phosphodiesterase deficiency
Acid sphingomyelinase deficiency: prevalence and characterization of an intermediate phenotype of Niemann-Pick disease.
sphingomyelin phosphodiesterase deficiency
Acid Sphingomyelinase Inhibition Prevents Development of Sepsis Sequelae in the Murine Liver.
sphingomyelin phosphodiesterase deficiency
Acid sphingomyelinase possesses a domain homologous to its activator proteins: saposins B and D.
sphingomyelin phosphodiesterase deficiency
Adrenal changes in Niemann-Pick disease: differences between sphingomyelinase deficiency and type C.
sphingomyelin phosphodiesterase deficiency
Adult Niemann-Pick disease masquerading as sea blue histiocyte syndrome: report of a case confirmed by lipid analysis and enzyme assays.
sphingomyelin phosphodiesterase deficiency
Adult sphingomyelinase deficiency: report of 2 patients who initially presented with psychiatric disorders.
sphingomyelin phosphodiesterase deficiency
Altered Lipid Metabolism in Brain Injury and Disorders.
sphingomyelin phosphodiesterase deficiency
Altered lipid metabolism in brain injury and disorders.
sphingomyelin phosphodiesterase deficiency
Altered Macrophage Function Associated with Crystalline Lung Inflammation in Acid Sphingomyelinase Deficiency.
sphingomyelin phosphodiesterase deficiency
An animal model of human acid sphingomyelinase deficiency (Niemann-Pick disease) and the study of its enzyme replacement (the Japan Society of Human Genetics award lecture).
sphingomyelin phosphodiesterase deficiency
An Early-Onset Neuronopathic Form of Acid Sphingomyelinase Deficiency: A SMPD1 p.C133Y Mutation in the Saposin Domain of Acid Sphingomyelinase.
sphingomyelin phosphodiesterase deficiency
Application of a glycinated bile acid biomarker for diagnosis and assessment of response to treatment in Niemann-pick disease type C1.
sphingomyelin phosphodiesterase deficiency
Autopsy pathology of infantile neurovisceral ASMD (Niemann-Pick Disease type A): Clinicopathologic correlations of a case report.
sphingomyelin phosphodiesterase deficiency
Bax and Bak do not exhibit functional redundancy in mediating radiation-induced endothelial apoptosis in the intestinal mucosa.
sphingomyelin phosphodiesterase deficiency
Biochemical and imaging parameters in acid sphingomyelinase deficiency: Potential utility as biomarkers.
sphingomyelin phosphodiesterase deficiency
Burden of Illness in Acid Sphingomyelinase Deficiency: A Retrospective Chart Review of 100 Patients.
sphingomyelin phosphodiesterase deficiency
Case Report of Gastrointestinal Bleeding in an Adult with Chronic Visceral Acid Sphingomyelinase Deficiency.
sphingomyelin phosphodiesterase deficiency
Cause of death in patients with chronic visceral and chronic neurovisceral acid sphingomyelinase deficiency (Niemann-Pick disease type B and B variant): Literature review and report of new cases.
sphingomyelin phosphodiesterase deficiency
Chronic Niemann-Pick disease with sphingomyelinase deficiency in two brothers with mental retardation.
sphingomyelin phosphodiesterase deficiency
Chronic visceral acid sphingomyelinase deficiency (Niemann-Pick disease type B) in 16 Polish patients: long-term follow-up.
sphingomyelin phosphodiesterase deficiency
Clearance of Hepatic Sphingomyelin by Olipudase Alfa Is Associated With Improvement in Lipid Profiles in Acid Sphingomyelinase Deficiency.
sphingomyelin phosphodiesterase deficiency
Clinical relevance of endpoints in clinical trials for acid sphingomyelinase deficiency enzyme replacement therapy.
sphingomyelin phosphodiesterase deficiency
Combined Emphysema and Interstitial Lung Disease as a Rare Presentation of Pulmonary Involvement in a Patient with Chronic Visceral Acid Sphingomyelinase Deficiency (Niemann-Pick Disease Type B).
sphingomyelin phosphodiesterase deficiency
Complex kinetics of bis(4-methylumbelliferyl)phosphate and hexadecanoyl(nitrophenyl)phosphorylcholine hydrolysis by purified sphingomyelinase in the presence of Triton X-100.
sphingomyelin phosphodiesterase deficiency
Consensus recommendation for a diagnostic guideline for acid sphingomyelinase deficiency.
sphingomyelin phosphodiesterase deficiency
Correction of sphingomyelinase deficiency in Niemann-Pick type C fibroblasts by removal of lipoprotein fraction from culture media.
sphingomyelin phosphodiesterase deficiency
Corrigendum to "Cause of death in patients with chronic visceral and chronic neurovisceral acid sphingomyelinase deficiency (Niemann-Pick disease type B and B variant): Literature review and report of new cases" [Mol. Genet. Metab. 118 (2016) 206-213].
sphingomyelin phosphodiesterase deficiency
Critical assessment of chitotriosidase analysis in the rational laboratory diagnosis of children with Gaucher disease and Niemann-Pick disease type A/B and C.
sphingomyelin phosphodiesterase deficiency
Deficiency of phospholipase C acting on phosphatidylglycerol in Niemann-Pick disease.
sphingomyelin phosphodiesterase deficiency
Deficiency of taurocholate-dependent phospholipase C acting on phosphatidylcholine in Niemann-Pick disease.
sphingomyelin phosphodiesterase deficiency
Deposition of lipopigment--a new feature of human splenic sinus endothelium (SSE). Ultrastructural and histochemical study.
sphingomyelin phosphodiesterase deficiency
Disease manifestations and burden of illness in patients with acid sphingomyelinase deficiency (ASMD).
sphingomyelin phosphodiesterase deficiency
Dual diagnosis of Ochoa syndrome and Niemann-Pick disease type B in a consanguineous family.
sphingomyelin phosphodiesterase deficiency
Effect of dimethylsulfoxide on sphingomyelinase activity and cholesterol metabolism in Niemann-Pick type C fibroblasts.
sphingomyelin phosphodiesterase deficiency
Effect of host cell lipid metabolism on alphavirus replication, virion morphogenesis, and infectivity.
sphingomyelin phosphodiesterase deficiency
Effects of acid sphingomyelinase deficiency on male germ cell development and programmed cell death.
sphingomyelin phosphodiesterase deficiency
Effects of dimethylsulfoxide on sphingomyelinase in cultured human fibroblasts and correction of sphingomyelinase deficiency in fibroblasts from Niemann-Pick patients.
sphingomyelin phosphodiesterase deficiency
Enhanced Delivery and Effects of Acid Sphingomyelinase by ICAM-1-Targeted Nanocarriers in Type B Niemann-Pick Disease Mice.
sphingomyelin phosphodiesterase deficiency
Functional characterization of novel variants in SMPD1 in Indian patients with acid sphingomyelinase deficiency.
sphingomyelin phosphodiesterase deficiency
Gelastic cataplexy in Niemann-Pick disease group C and related variants without generalized sphingomyelinase deficiency.
sphingomyelin phosphodiesterase deficiency
Homozygous pArg610del Mutation Unusually Associated With Severe Delay of Growth in 2 Acid Sphingomyelinase Deficiency-affected Sibs.
sphingomyelin phosphodiesterase deficiency
Homozygous Smpd1 deficiency aggravates brain ischemia/ reperfusion injury by mechanisms involving polymorphonuclear neutrophils, whereas heterozygous Smpd1 deficiency protects against mild focal cerebral ischemia.
sphingomyelin phosphodiesterase deficiency
Human acid sphingomyelinase.
sphingomyelin phosphodiesterase deficiency
Identification and biochemical characterization of an acid sphingomyelinase-like protein from the bacterial plant pathogen Ralstonia solanacearum that hydrolyzes ATP to AMP but not sphingomyelin to ceramide.
sphingomyelin phosphodiesterase deficiency
Identification of a distinct mutation spectrum in the SMPD1 gene of Chinese patients with acid sphingomyelinase-deficient Niemann-Pick disease.
sphingomyelin phosphodiesterase deficiency
Increased liver tumor formation in neutral sphingomyelinase-2 deficient mice.
sphingomyelin phosphodiesterase deficiency
Inhibition of fatty acid amide hydrolase prevents pathology in neurovisceral acid sphingomyelinase deficiency by rescuing defective endocannabinoid signaling.
sphingomyelin phosphodiesterase deficiency
Interstitial lung disease in lysosomal storage disorders.
sphingomyelin phosphodiesterase deficiency
Isolation of Alpha-Toxin-Deficient Clostridium perfringens Type F from Sewage Influents and Effluents.
sphingomyelin phosphodiesterase deficiency
Ito cells in lysosomal storage disorders. An ultrastructural study.
sphingomyelin phosphodiesterase deficiency
Limited benefits of presymptomatic cord blood transplantation in neurovisceral acid sphingomyelinase deficiency (ASMD) intermediate type.
sphingomyelin phosphodiesterase deficiency
Lipid abnormalities in children with types A and B Niemann Pick disease.
sphingomyelin phosphodiesterase deficiency
Liver and skin histopathology in adults with acid sphingomyelinase deficiency (Niemann-Pick disease type B).
sphingomyelin phosphodiesterase deficiency
Local regulation of tooth mineralization by sphingomyelin phosphodiesterase 3.
sphingomyelin phosphodiesterase deficiency
Long-term efficacy of olipudase alfa in adults with acid sphingomyelinase deficiency (ASMD): Further clearance of hepatic sphingomyelin is associated with additional improvements in pro- and anti-atherogenic lipid profiles after 42 months of treatment.
sphingomyelin phosphodiesterase deficiency
Macula halo syndrome. Variant of Niemann-Pick disease.
sphingomyelin phosphodiesterase deficiency
Mitochondrial biogenesis is transcriptionally repressed in lysosomal lipid storage diseases.
sphingomyelin phosphodiesterase deficiency
Molecular analysis of the acid sphingomyelinase deficiency in a family with an intermediate form of Niemann-Pick disease.
sphingomyelin phosphodiesterase deficiency
Molecular basis of acid sphingomyelinase deficiency in a patient with Niemann-Pick disease type A.
sphingomyelin phosphodiesterase deficiency
MRI in an unusually protracted neuronopathic variant of acid sphingomyelinase deficiency.
sphingomyelin phosphodiesterase deficiency
Neutral Sphingomyelinase (SMPD3) Deficiency Causes a Novel Form of Chondrodysplasia and Dwarfism That Is Rescued by Col2A1-Driven smpd3 Transgene Expression.
sphingomyelin phosphodiesterase deficiency
Neutral sphingomyelinase (SMPD3) deficiency causes a novel form of chondrodysplasia and dwarfism that is rescued by Col2A1-driven smpd3 transgene expression.
sphingomyelin phosphodiesterase deficiency
Neutral sphingomyelinase (SMPD3) deficiency disrupts the Golgi secretory pathway and causes growth inhibition.
sphingomyelin phosphodiesterase deficiency
Neutral sphingomyelinase 1 deficiency in the mouse causes no lipid storage disease.
sphingomyelin phosphodiesterase deficiency
Neutral Sphingomyelinase 2 (SMPD3) Deficiency in Mice Causes Chondrodysplasia with Unimpaired Skeletal Mineralization.
sphingomyelin phosphodiesterase deficiency
Neutral sphingomyelinase 2 deficiency increases hyaluronan synthesis by up-regulation of hyaluronan Synthase 2 through decreased ceramide production and activation of Akt.
sphingomyelin phosphodiesterase deficiency
Neutral sphingomyelinase 2 deficiency is associated with lung anomalies similar to emphysema.
sphingomyelin phosphodiesterase deficiency
Neutral Sphingomyelinase-2 Deficiency Ameliorates Alzheimer's Disease Pathology and Improves Cognition in the 5XFAD Mouse.
sphingomyelin phosphodiesterase deficiency
New findings in pathology of storage.
sphingomyelin phosphodiesterase deficiency
Niemann-Pick disease (variation in the sphingomyelinase deficient group). Neurovisceral phenotype (A) with an abnormally protracted clinical course and variable expression of neurological symptomatology in three siblings.
sphingomyelin phosphodiesterase deficiency
Niemann-Pick disease and juvenile xanthogranuloma. Are they related?
sphingomyelin phosphodiesterase deficiency
Niemann-Pick disease type A and B are clinically but also enzymatically heterogeneous: pitfall in the laboratory diagnosis of sphingomyelinase deficiency associated with the mutation Q292 K.
sphingomyelin phosphodiesterase deficiency
Niemann-Pick Disease versus acid sphingomyelinase deficiency.
sphingomyelin phosphodiesterase deficiency
Niemann-Pick disease.
sphingomyelin phosphodiesterase deficiency
Niemann-Pick disease: lipid storage in bone marrow macrophages.
sphingomyelin phosphodiesterase deficiency
Niemann-Pick type C disease: Novel NPC1 mutations and characterization of the concomitant acid sphingomyelinase deficiency.
sphingomyelin phosphodiesterase deficiency
Niemann-Pick type C disease: The atypical sphingolipidosis.
sphingomyelin phosphodiesterase deficiency
Nonclinical safety assessment of recombinant human acid sphingomyelinase (rhASM) for the treatment of acid sphingomyelinase deficiency:the utility of animal models of disease in the toxicological evaluation of potential therapeutics.
sphingomyelin phosphodiesterase deficiency
Novel mutations in the SMPD1 gene in Jordanian children with Acid sphingomyelinase deficiency (Niemann-Pick types A and B).
sphingomyelin phosphodiesterase deficiency
Ocular manifestations of adult Niemann-Pick disease: a case report.
sphingomyelin phosphodiesterase deficiency
Ocular pathology of infantile Niemann-Pick disease. Study of fetus of 23 weeks' gestation.
sphingomyelin phosphodiesterase deficiency
Olipudase alfa for treatment of acid sphingomyelinase deficiency (ASMD): safety and efficacy in adults treated for 30 months.
sphingomyelin phosphodiesterase deficiency
One-year results of a clinical trial of olipudase alfa enzyme replacement therapy in pediatric patients with acid sphingomyelinase deficiency.
sphingomyelin phosphodiesterase deficiency
Optimization of a histopathological biomarker for sphingomyelin accumulation in Acid sphingomyelinase deficiency.
sphingomyelin phosphodiesterase deficiency
Oral, dental, and craniofacial features in chronic acid sphingomyelinase deficiency.
sphingomyelin phosphodiesterase deficiency
Partial sphingomyelinase deficiency with sea-blue histiocytosis and neurovisceral dysfunction.
sphingomyelin phosphodiesterase deficiency
Pathogenesis of one variant of sea-blue histiocytosis.
sphingomyelin phosphodiesterase deficiency
Periodontal condition and treatment in a patient with rare systemic condition: A case report for acid sphingomyelinase deficiency.
sphingomyelin phosphodiesterase deficiency
Peripheral neuropathy in type A Niemann-Pick disease. A morphological study.
sphingomyelin phosphodiesterase deficiency
Phenotypic and genetic heterogeneity in Niemann-Pick disease type C: current knowledge and practical implications.
sphingomyelin phosphodiesterase deficiency
Plasma lyso-sphingomyelin levels are positively associated with clinical severity in acid sphingomyelinase deficiency.
sphingomyelin phosphodiesterase deficiency
Polyneuropathy in feline Niemann-Pick disease.
sphingomyelin phosphodiesterase deficiency
Prospective study of the natural history of chronic acid sphingomyelinase deficiency in children and adults: eleven years of observation.
sphingomyelin phosphodiesterase deficiency
Quantitation of plasmatic lysosphingomyelin and lysosphingomyelin-509 for differential screening of Niemann-Pick A/B and C diseases.
sphingomyelin phosphodiesterase deficiency
Quantitative Systems Pharmacology Modeling of Acid Sphingomyelinase Deficiency and the Enzyme Replacement Therapy Olipudase Alfa Is an Innovative Tool for Linking Pathophysiology and Pharmacology.
sphingomyelin phosphodiesterase deficiency
Radiation-induced apoptosis of endothelial cells in the murine central nervous system: protection by fibroblast growth factor and sphingomyelinase deficiency.
sphingomyelin phosphodiesterase deficiency
Rapid screening for lipid storage disorders using biochemical markers. Expert center data and review of the literature.
sphingomyelin phosphodiesterase deficiency
Recommendations for clinical monitoring of patients with acid sphingomyelinase deficiency (ASMD).
sphingomyelin phosphodiesterase deficiency
Reconstruction of the Cytokine Signaling in Lysosomal Storage Diseases by Literature Mining and Network Analysis.
sphingomyelin phosphodiesterase deficiency
Regulation of Chlamydomonas flagella and ependymal cell motile cilia by ceramide-mediated translocation of GSK3.
sphingomyelin phosphodiesterase deficiency
Reliable Assay of Acid Sphingomyelinase Deficiency with the Mutation Q292K by Tandem Mass Spectrometry.
sphingomyelin phosphodiesterase deficiency
Respiratory impairment in Niemann-Pick B disease: Two case reports and review for the pulmonologist.
sphingomyelin phosphodiesterase deficiency
Role of acidic sphingomyelinase in Fas/CD95-mediated cell death.
sphingomyelin phosphodiesterase deficiency
Role of SMPD3 during Bone Fracture Healing and Regulation of Its Expression.
sphingomyelin phosphodiesterase deficiency
Serum Zn(2+)-stimulated sphingomyelinase deficiency in type B Niemann-Pick disease.
sphingomyelin phosphodiesterase deficiency
Seven novel mutations of the SMPD1 gene in four Chinese patients with Niemann-Pick disease type A and prenatal diagnosis for four fetuses.
sphingomyelin phosphodiesterase deficiency
Signaling in and regulation of ionizing radiation-induced apoptosis in endothelial cells.
sphingomyelin phosphodiesterase deficiency
Skeletal manifestations in pediatric and adult patients with Niemann Pick disease type B.
sphingomyelin phosphodiesterase deficiency
SMPD3 deficiency perturbs neuronal proteostasis and causes progressive cognitive impairment.
sphingomyelin phosphodiesterase deficiency
SMPDL3b modulates insulin receptor signaling in diabetic kidney disease.
sphingomyelin phosphodiesterase deficiency
Sphingolipid metabolism and its role in the skeletal tissues.
sphingomyelin phosphodiesterase deficiency
Sphingomyelin lipidosis (Niemann-Pick disease) in a juvenile raccoon (Procyon lotor).
sphingomyelin phosphodiesterase deficiency
Sphingomyelinase activities of various human tissues in control subjects and in Niemann-Pick disease - development and evaluation of a microprocedure.
sphingomyelin phosphodiesterase deficiency
Sphingomyelinase deficiency (Niemann-Pick disease) in a Hereford calf.
sphingomyelin phosphodiesterase deficiency
Splenic histiocytosis in idiopathic thrombocytopenic purpura: a relative sphingomyelinase deficiency?
sphingomyelin phosphodiesterase deficiency
Structural and functional analysis of the ASM p.Ala359Asp mutant that causes acid sphingomyelinase deficiency.
sphingomyelin phosphodiesterase deficiency
Subclinical course of adult visceral Niemann-Pick type C1 disease. A rare or underdiagnosed disorder?
sphingomyelin phosphodiesterase deficiency
Successful within-patient dose escalation of olipudase alfa in acid sphingomyelinase deficiency.
sphingomyelin phosphodiesterase deficiency
Synthesis of pyrenesulfonylamido-sphingomyelin and its use as substrate for determining sphingomyelinase activity and diagnosing Niemann-Pick disease.
sphingomyelin phosphodiesterase deficiency
The IL-1 receptor signaling pathway.
sphingomyelin phosphodiesterase deficiency
The impact of biomarkers analysis in the diagnosis of Niemann-Pick C disease and acid sphingomyelinase deficiency.
sphingomyelin phosphodiesterase deficiency
The natural history of type B Niemann-Pick disease: results from a 10-year longitudinal study.
sphingomyelin phosphodiesterase deficiency
Treatment of sphingomyelinase deficiency by repeated implantations of amniotic epithelial cells.
sphingomyelin phosphodiesterase deficiency
Tricyclic antidepressants induce sphingomyelinase deficiency in fibroblast and neuroblastoma cell cultures.
sphingomyelin phosphodiesterase deficiency
Twenty- five years of biochemical diagnosis of Gaucher disease: the Egyptian experience.
sphingomyelin phosphodiesterase deficiency
Two novel mutations in patients with atypical phenotypes of acid sphingomyelinase deficiency.
sphingomyelin phosphodiesterase deficiency
Two Siblings with Niemann-Pick Disease (NPD) Type B: Clinical Findings and Novel Mutations of the Acid Sphingomyelinase Gene.
sphingomyelin phosphodiesterase deficiency
Uptake and metabolism of radioactively labeled sphingomyelin in cultured skin fibroblasts from controls and patients with Niemann-Pick disease and other lysosomal storage diseases.
sphingomyelin phosphodiesterase deficiency
[Acid sphingomyelinase deficiency (Niemann-Pick disease type B) in adulthood: A retrospective multicentric study of 28 adult cases].
sphingomyelin phosphodiesterase deficiency
[Acid sphingomyelinase deficiency and spleen trauma: Splenectomy or not splenectomy?]
sphingomyelin phosphodiesterase deficiency
[Activators for sphingohydrolases and the nature of the sphingomyelinase deficiency in Niemann-Pick disease types A, B and C (author's transl)]
sphingomyelin phosphodiesterase deficiency
[Lipidosis with vertical gaze palsy, macular degeneration, and sphingomyelinase deficiency]
sphingomyelin phosphodiesterase deficiency
[Lysosomal sphingomyelinase deficiency: spectrum of phenotypes in Czech and Slovak patients]
sphingomyelin phosphodiesterase deficiency
[Niemann-Pick disease revealed late by miliary tuberculosis: diagnosis by leukocyte determination of sphingomyelinase deficiency]
sphingomyelin phosphodiesterase deficiency
[Perhexiline maleate induces sphingomyelinase deficiency in man]
sphingomyelin phosphodiesterase deficiency
[Sea-blue histiocyte syndrome (author's transl)]
sphingomyelin phosphodiesterase deficiency
[Sphingomyelinase deficiency (Niemann-Pick) type A. A new variant with an unusually prolonged course]
sphingomyelin phosphodiesterase deficiency
[Study of thesaurismosis induced by perhexiline maleate. Confirmation of experimental data]
Spinal Cord Injuries
Interactions between neural membrane glycerophospholipid and sphingolipid mediators: a recipe for neural cell survival or suicide.
Squamous Cell Carcinoma of Head and Neck
Acid sphingomyelinase activity as an indicator of the cell stress in HPV-positive and HPV-negative head and neck squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Sphingomyelin phosphodiesterase 3 methylation and silencing in oral squamous cell carcinoma results in increased migration and invasion and altered stress response.
Staphylococcal Infections
Acute bacterial skin and skin structure infection: Critical role of alpha-toxin and protective effects of its neutralization by a human antibody.
Staphylococcal Infections
Biology and clinical significance of peptidoglycan antibody response in staphylococcal infections.
Staphylococcal Infections
Effect of 2 Emulsion-Based Adjuvants on the Structure and Thermal Stability of Staphylococcus aureus Alpha-Toxin.
Staphylococcal Infections
Effects of amoxicillin, gentamicin, and moxifloxacin on the hemolytic activity of Staphylococcus aureus in vitro and in vivo.
Staphylococcal Infections
Incorporation of staphylococcal alpha-toxin in glutaraldehyde fixed erythrocytes.
Staphylococcal Infections
Interferons increase cell resistance to Staphylococcal alpha-toxin.
Staphylococcal Infections
Lipase versus teichoic acid and alpha-toxin as antigen in an enzyme immunoassay for serological diagnosis of Staphylococcus aureus infections.
Staphylococcal Infections
Local delivery of soluble interleukin-6 receptors to improve the outcome of alpha-toxin producing Staphylococcus aureus infection in mice.
Staphylococcal Infections
Regulated antisense RNA eliminates alpha-toxin virulence in Staphylococcus aureus infection.
Staphylococcal Infections
Regulation of Staphylococcus aureus Infection of Macrophages by CD44, Reactive Oxygen Species, and Acid Sphingomyelinase.
Staphylococcal Infections
Release of interleukin-1 beta associated with potent cytocidal action of staphylococcal alpha-toxin on human monocytes.
Staphylococcal Infections
Serological diagnosis of deep Staphylococcus aureus infections by enzyme-linked immunosorbent assay (ELISA) for staphylococcal hemolysins and teichoic acid.
Staphylococcal Infections
Stimulation of PAF-synthesis in pulmonary artery endothelial cells by Staphylococcus aureus alpha-toxin.
Staphylococcal Infections
The role of antibodies against alpha-toxin and teichoic acid in the diagnosis of staphylococcal infections.
Staphylococcal Infections
[Characteristics of a staphylococcal infection in guinea pigs with delayed hypersensitivity to staphylococcal alpha-toxin]
Staphylococcal Infections
[Development of approaches to studying the structural and functional organization of protein molecules aboard the International space station]
Staphylococcal Scalded Skin Syndrome
Staphylococcal scalded skin syndrome. II. Serum level of anti exfoliatin and anti alpha-toxin in patients with staphylococcal scalded skin syndrome or bullous impetigo.
Starvation
Activation of neutral sphingomyelinase 2 by starvation induces cell-protective autophagy via an increase in Golgi-localized ceramide.
Starvation
Hyaluronan synthase-2 upregulation protects smpd3-deficient fibroblasts against cell death induced by nutrient deprivation, but not against apoptosis evoked by oxidized LDL.
Starvation
[Functional state of a sphingomyeline cycle and free radical lipid oxidation activity of a rat's liver during different phases of starvation].
sterol esterase deficiency
Application of a glycinated bile acid biomarker for diagnosis and assessment of response to treatment in Niemann-pick disease type C1.
Stomach Neoplasms
Acid Sphingomyelinase Contributes to Evodiamine-Induced Apoptosis in Human Gastric Cancer SGC-7901 Cells.
Stomach Neoplasms
Gentamicin Targets Acid Sphingomyelinase in Cancer: The Case of the Human Gastric Cancer NCI-N87 Cells.
Stroke
Changes in the cerebrospinal fluid lipid profile following subarachnoid hemorrhage in a closed cranium model: Correlations to cerebral vasospasm, neuronal cell death and Interleukin-6 synthesis. A pilot study.
Stroke
Interactions between neural membrane glycerophospholipid and sphingolipid mediators: a recipe for neural cell survival or suicide.
Stroke
Neonatal stroke enhances interaction of microglia-derived extracellular vesicles with microglial cells.
Stroke
Neutral sphingomyelinase: past, present and future.
Stroke
Pivotal role for acidic sphingomyelinase in cerebral ischemia-induced ceramide and cytokine production, and neuronal apoptosis.
Stroke
Sphingolipids in atherosclerosis and vascular biology.
Stroke
Sphingomyelinase and ceramide analogs induce vasoconstriction and leukocyte-endothelial interactions in cerebral venules in the intact rat brain: Insight into mechanisms and possible relation to brain injury and stroke.
Stroke
The Acid Sphingomyelinase/ Ceramide System as Target for Ischemic Stroke Therapies.
Surgical Wound Infection
Efficacy of a Multimechanistic Monoclonal Antibody Combination against Staphylococcus aureus Surgical Site Infections in Mice.
Synucleinopathies
Lysosomal enzyme activities as possible CSF biomarkers of synucleinopathies.
Systemic Vasculitis
Elevated active secretory sphingomyelinase in antineutrophil cytoplasmic antibody-associated primary systemic vasculitis.
Tay-Sachs Disease
Bi-functional IgG-lysosomal enzyme fusion proteins for brain drug delivery.
Tendinopathy
Selected Clinical Features Fail to Predict Inflammatory Gene Expressions for TNF-?, TNFR1, NSMAF, Casp3 and IL-8 in Tendons of Patients with Rotator Cuff Tendinopathy.
Tetanus
Bacterial toxins: friends or foes?
Tetanus
Comparative study of immune status to infectious agents in elderly patients with multiple myeloma, Waldenstrom's macroglobulinemia, and monoclonal gammopathy of undetermined significance.
Tetanus
Distinct targets for tetanus and botulinum A neurotoxins within the signal transducing pathway in chromaffin cells.
Tetanus
Multiple effects of alpha-toxins on the nicotinic acetylcholine receptor.
Tetanus
Probiotics stimulate production of natural antibodies in chickens.
Tetanus
Protein antigens increase the protective efficacy of a capsule-based vaccine against Staphylococcus aureus in a rat model of osteomyelitis.
Tetanus
Some general rules governing fate and action of polypeptide and protein drugs, as derived from investigations with staphylococcal alpha-toxin, tetanus toxin, and so-calledd crotoxin.
Thrombocytopenia
Acute Gaucher Disease-Like Condition in an Indian Infant with a Novel Biallelic Mutation in the Prosaposin Gene.
Thrombophilia
SARS-CoV-2 infection induces the activation of tissue factor-mediated coagulation via activation of acid sphingomyelinase.
Thrombophilia
The Role of Chemoprophylactic Agents in Modulating Platelet Aggregability After Traumatic Brain Injury.
Thrombosis
Acid sphingomyelinase regulates platelet cell membrane scrambling, secretion, and thrombus formation.
Thrombosis
Identification of key lipids critical for platelet activation by comprehensive analysis of the platelet lipidome.
Toxemia
Relation of in vitro inhibition by chelates of Clostridium perfringens alpha-toxin to their ability to protect against experimental toxemia.
Toxemia
STUDIES OF THE EFFECT OF ALDOSTERONE IN THE EXPERIMENTAL TOXEMIA WITH THE ALPHA-TOXIN OF CLOSTRIDIUM WELCHII.
Toxic Optic Neuropathy
Specific roles of alpha-toxin and beta-toxin during Staphylococcus aureus corneal infection.
Transfusion-Related Acute Lung Injury
Platelet extracellular vesicles mediate transfusion-related acute lung injury by imbalancing the sphingolipid rheostat.
Tremor
Staphylococcal alpha toxin induced changes in the electroencephalogram of the rat.
Tuberculosis
A novel class of microbial phosphocholine-specific phospholipases C.
Tuberculosis
An acidic sphingomyelinase Type C activity from Mycobacterium tuberculosis.
Tuberculosis
Extracellular Sphingomyelinase Rv0888 of Mycobacterium tuberculosis Contributes to Pathological Lung Injury of Mycobacterium smegmatis in Mice via Inducing Formation of Neutrophil Extracellular Traps.
Tuberculosis
Identification of acidic, alkaline, and neutral sphingomyelinase activities in Mycobacterium tuberculosis.
Tuberculosis
Inhibition of neutral sphingomyelinase protects mice against systemic tuberculosis.
Tuberculosis
Sphingomyelinase D/ceramide 1-phosphate in cell survival and inflammation.
Tuberculosis, Miliary
[Niemann-Pick disease revealed late by miliary tuberculosis: diagnosis by leukocyte determination of sphingomyelinase deficiency]
Urinary Tract Infections
Hemolysin and K antigens in relation to serotype and hemagglutination type of Escherichia coli isolated from extraintestinal infections.
Uterine Cervicitis
Cervicovaginal Inflammatory Cytokines and Sphingomyelinase in Women With and Without Bacterial Vaginosis.
Vaccinia
Recombinant vaccinia viruses protect against Clostridium perfringens alpha-toxin.
Vaginitis
Cervicovaginal Inflammatory Cytokines and Sphingomyelinase in Women With and Without Bacterial Vaginosis.
Vaginosis, Bacterial
Cervicovaginal Inflammatory Cytokines and Sphingomyelinase in Women With and Without Bacterial Vaginosis.
Vascular Calcification
Acid sphingomyelinase promotes SGK1-dependent vascular calcification.
Vascular Calcification
Ceramide mediates Ox-LDL-induced human vascular smooth muscle cell calcification via p38 mitogen-activated protein kinase signaling.
Vascular System Injuries
Chemotherapy-induced acute vascular injury involves intracellular generation of ROS via activation of the acid sphingomyelinase pathway.
Vascular System Injuries
Enhancement of Soft Tissue Sarcoma Response to Gemcitabine through Timed Administration of a Short-Acting Anti-Angiogenic Agent.
Vesicular Stomatitis
Pharmacological Inhibition of Acid Sphingomyelinase Prevents Uptake of SARS-CoV-2 by Epithelial Cells.
Virus Diseases
Ceramide and cell death receptor clustering.
Virus Diseases
Depletion of Host and Viral Sphingomyelin Impairs Influenza Virus Infection.
Virus Diseases
Differential role of sphingomyelin in influenza virus, rhinovirus and SARS-CoV-2 infection of Calu-3 cells.
Virus Diseases
Oxidative Stress Triggers Ca-Dependent Lysosome Trafficking and Activation of Acid Sphingomyelinase.
Virus Diseases
SARS-CoV-2 infection induces the activation of tissue factor-mediated coagulation via activation of acid sphingomyelinase.
Whooping Cough
Aerolysin induces G-protein activation and Ca2+ release from intracellular stores in human granulocytes.
Whooping Cough
Hemolysis induced by Bacillus cereus sphingomyelinase.
Whooping Cough
Pertussis toxin promotes macrophage survival through inhibition of acid sphingomyelinase and activation of the phosphoinositide 3-kinase/protein kinase B pathway.
Whooping Cough
The relationship between the metabolism of sphingomyelin species and the hemolysis of sheep erythrocytes induced by Clostridium perfringens {alpha}-toxin.
Whooping Cough
The sphingomyelin/ceramide pathway is involved in ERK1/2 phosphorylation, cell proliferation, and uPAR overexpression induced by tissue-type plasminogen activator.
Wolman Disease
Application of a glycinated bile acid biomarker for diagnosis and assessment of response to treatment in Niemann-pick disease type C1.
Wolman Disease
Ito cells in lysosomal storage disorders. An ultrastructural study.
Wound Infection
Positive camp-phenomenon elicited by coagulase-negative staphylococci.
Wound Infection
Virulence factors of Staphylococcus aureus in the pathogenesis of endocarditis. A comparative study of clinical isolates.
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