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Information on EC 3.1.4.11 - phosphoinositide phospholipase C and Organism(s) Xenopus tropicalis
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3.1.4.11 phosphoinositide phospholipase CIUBMB Comments
These enzymes form some of the cyclic phosphate Ins(cyclic1,2)P(4,5)P2 as well as Ins(1,4,5)P3. They show activity towards phosphatidylinositol, i.e., the activity of EC 4.6.1.13, phosphatidylinositol diacylglycerol-lyase, in vitro at high [Ca2+]. Four beta-isoforms regulated by G-proteins, two gamma-forms regulated by tyrosine kinases, four delta-forms regulated at least in part by calcium and an epsilon-form, probably regulated by the oncogene ras, have been found.
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Word Map
- 3.1.4.11
- diacylglycerol
- phospholipid
- pkc
- agonist
- isozymes
- 1,4,5-trisphosphate
-
gpi-anchored
- platelet
- 3-kinase
- phosphatidylcholine
- pertussis
- syk
- g-proteins
- egf
-
phosphatidic
-
platelet-derived
-
muscarinic
- thuringiensis
-
tyrosine-phosphorylated
- trisphosphate
-
glycosyl-phosphatidylinositol
-
glycosylphosphatidylinositol-anchored
-
3hinositol
- grb2
- carbachol
- phosphotyrosine
- gbetagamma
-
phosphatidylcholine-specific
-
ptdins4,5p2
-
gpi-linked
-
phototransduction
- inositol-1,4,5-trisphosphate
- galphaq
- 1,2-diacylglycerol
-
pdgf-induced
-
bruton
- insp3
-
sperm-specific
- vav
-
decay-accelerating
- fcepsilonri
- phosphatidylethanol
-
itams
-
toxin-insensitive
- alphaiibbeta3
-
tcr-mediated
-
rasgap
-
p56lck
-
tcr-induced
-
gbeta
- drug development
- medicine
- food industry
- pharmacology
The taxonomic range for the selected organisms is: Xenopus tropicalis
The enzyme appears in selected viruses and cellular organisms
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
Synonyms
pi-plc, phosphatidylinositol-specific phospholipase c, plc-gamma, plc-gamma1, plcgamma1, plc-beta, plcgamma, phosphoinositide-specific phospholipase c, plcgamma2, phospholipase c-gamma1, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
1-phosphatidyl-D-myo-inositol 4,5-bisphosphate inositoltrisphosphohydrolase
-
-
-
-
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase
-
-
-
-
No receptor potential A protein
-
-
-
-
phosphatidylinositol 4,5-bisphosphate phosphodiesterase
-
-
-
-
phosphatidylinositol-4,5-bisphosphate phosphodiesterase
-
-
-
-
phosphatidylinositol-4,5-bisphosphate phospholipase C
-
-
-
-
phosphodiesterase, triphosphoinositide
-
-
-
-
phosphoinositidase C
-
-
-
-
phospholipase C
-
-
-
-
phosphotidylinositol 4,5-bisphosphate-specific phospholipase C
-
-
-
-
PIC
-
-
-
-
PIP2 PDE
-
-
-
-
PIP2 phosphodiesterase
-
-
-
-
PIPLC
-
-
-
-
PLC
-
-
-
-
PLC-148
-
-
-
-
PLC-154
-
-
-
-
PLC-85
-
-
-
-
polyphosphoinositide phospholipase C
-
-
-
-
PtdIns(4,5)P2-directed phospholipase C
-
-
-
-
triphosphoinositide phosphodiesterase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of phosphoric ester
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase
These enzymes form some of the cyclic phosphate Ins(cyclic1,2)P(4,5)P2 as well as Ins(1,4,5)P3. They show activity towards phosphatidylinositol, i.e., the activity of EC 4.6.1.13, phosphatidylinositol diacylglycerol-lyase, in vitro at high [Ca2+]. Four beta-isoforms regulated by G-proteins, two gamma-forms regulated by tyrosine kinases, four delta-forms regulated at least in part by calcium and an epsilon-form, probably regulated by the oncogene ras, have been found.
CAS REGISTRY NUMBER
COMMENTARY
37213-51-7
-
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). A0A6I8RP50_XENTR
2321
0
261006
TrEMBL
other Location (Reliability: 4)
A0A6I8SU88_XENTR
1102
0
123410
TrEMBL
other Location (Reliability: 4)
F6VHL8_XENTR
1045
0
117257
TrEMBL
other Location (Reliability: 1)
A0A6I8SCM0_XENTR
1260
0
146929
TrEMBL
other Location (Reliability: 3)
A8E4T8_XENTR
887
0
100840
TrEMBL
other Location (Reliability: 1)
A0A6I8R523_XENTR
1234
0
139098
TrEMBL
other Location (Reliability: 2)
F7ENR4_XENTR
1614
0
183222
TrEMBL
Mitochondrion (Reliability: 5)
A0A8J0QQC4_XENTR
1259
0
146660
TrEMBL
other Location (Reliability: 3)
F7B628_XENTR
1256
0
146194
TrEMBL
other Location (Reliability: 3)
A0A6I8SC51_XENTR
804
0
92549
TrEMBL
other Location (Reliability: 3)
A0A8J1JJZ9_XENTR
1641
0
186313
TrEMBL
Mitochondrion (Reliability: 5)
A0A8J1JTZ0_XENTR
1552
0
173913
TrEMBL
other Location (Reliability: 2)
A0A8J1JXS0_XENTR
1576
0
176432
TrEMBL
other Location (Reliability: 2)
A0A5S6JWJ1_XENTR
1105
0
125644
TrEMBL
other Location (Reliability: 3)
A0A8J1JV91_XENTR
2346
0
263724
TrEMBL
other Location (Reliability: 4)
A0A8J1JIJ5_XENTR
1223
0
139115
TrEMBL
other Location (Reliability: 3)
A0A8J1JZ72_XENTR
2332
0
262330
TrEMBL
other Location (Reliability: 4)
A0A6I8SLR0_XENTR
1232
0
143150
TrEMBL
other Location (Reliability: 2)
A0A8J0SWI7_XENTR
1059
0
118972
TrEMBL
other Location (Reliability: 2)
A0A803K9Y4_XENTR
988
0
111665
TrEMBL
other Location (Reliability: 2)
A0A8J0SVR0_XENTR
1560
0
175267
TrEMBL
Mitochondrion (Reliability: 2)
A0A8J1JNL5_XENTR
1661
0
188567
TrEMBL
Mitochondrion (Reliability: 5)
A0A8J1JPU2_XENTR
1111
0
129130
TrEMBL
other Location (Reliability: 2)
A0A6I8QFB2_XENTR
1115
0
127282
TrEMBL
other Location (Reliability: 1)
A0A6I8SGN2_XENTR
1554
0
174033
TrEMBL
other Location (Reliability: 1)
A0A8J1J1A0_XENTR
744
0
85902
TrEMBL
other Location (Reliability: 4)
A4IJ09_XENTR
548
0
62540
TrEMBL
other Location (Reliability: 1)
A0A6I8SIN2_XENTR
1186
0
135221
TrEMBL
other Location (Reliability: 1)
F7C4D9_XENTR
1191
0
137250
TrEMBL
other Location (Reliability: 2)
A0A1B8Y9Z8_XENTR
1002
0
111562
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8J1JLI1_XENTR
1205
0
136837
TrEMBL
other Location (Reliability: 1)
A0A803KC86_XENTR
1113
0
124679
TrEMBL
other Location (Reliability: 1)
A0A6I8QMQ7_XENTR
1145
0
130285
TrEMBL
other Location (Reliability: 1)
A0A6I8SSV8_XENTR
1198
0
136291
TrEMBL
other Location (Reliability: 1)
F6Z8A1_XENTR
1274
0
147909
TrEMBL
other Location (Reliability: 2)
A0A6I8SAV0_XENTR
1609
0
180297
TrEMBL
other Location (Reliability: 2)
A0A6I8Q8D2_XENTR
1242
0
143926
TrEMBL
other Location (Reliability: 2)
A0A6I8S2E2_XENTR
1248
0
144744
TrEMBL
other Location (Reliability: 1)
A0A6I8SP63_XENTR
758
0
87263
TrEMBL
other Location (Reliability: 4)
A0A6I8R459_XENTR
1210
0
138867
TrEMBL
other Location (Reliability: 2)
A0A8J1JV96_XENTR
2303
0
258936
TrEMBL
other Location (Reliability: 4)
A0A8J1JPU1_XENTR
1155
0
133848
TrEMBL
other Location (Reliability: 4)
A0A8J0S5G2_XENTR
1036
0
117018
TrEMBL
Mitochondrion (Reliability: 5)
A0A6I8SDL6_XENTR
1225
0
139356
TrEMBL
other Location (Reliability: 3)
A0A6I8RAC7_XENTR
1141
0
129463
TrEMBL
other Location (Reliability: 1)
F6WH18_XENTR
1092
0
124056
TrEMBL
other Location (Reliability: 1)
A0A8J1JXP4_XENTR
2335
0
262401
TrEMBL
other Location (Reliability: 4)
A0A8J1JJZ6_XENTR
1035
0
118061
TrEMBL
Mitochondrion (Reliability: 5)
A0A8J1JHL1_XENTR
1198
0
137718
TrEMBL
Mitochondrion (Reliability: 3)
A0A6I8RXG1_XENTR
1156
0
133148
TrEMBL
other Location (Reliability: 2)
Q0VFK7_XENTR
426
0
48212
TrEMBL
other Location (Reliability: 3)
A0A5S6P4A7_XENTR
1048
0
120096
TrEMBL
other Location (Reliability: 2)
F6YW30_XENTR
1301
0
151017
TrEMBL
other Location (Reliability: 2)
A0A6I8SHT0_XENTR
1231
0
139840
TrEMBL
other Location (Reliability: 3)
F7B8D2_XENTR
1254
0
141443
TrEMBL
other Location (Reliability: 2)
F6RLC5_XENTR
758
0
87316
TrEMBL
other Location (Reliability: 4)
A0A6I8RHI4_XENTR
1197
0
139390
TrEMBL
other Location (Reliability: 3)
F7BGK4_XENTR
1180
0
134065
TrEMBL
other Location (Reliability: 3)
A0A803K0P7_XENTR
1002
0
113055
TrEMBL
other Location (Reliability: 2)
A0A1B8XSG3_XENTR
689
0
78336
TrEMBL
other Location (Reliability: 4)
A0A6I8QCS0_XENTR
1634
0
185475
TrEMBL
Mitochondrion (Reliability: 5)
A0A6I8Q9Q8_XENTR
763
0
86899
TrEMBL
other Location (Reliability: 1)
B1WB59_XENTR
596
6
67903
TrEMBL
Secretory Pathway (Reliability: 5)
A0A8J1JTY7_XENTR
1023
0
115579
TrEMBL
other Location (Reliability: 2)
A0A6I8QLK5_XENTR
2306
0
259007
TrEMBL
other Location (Reliability: 4)
A0A8J0QN11_XENTR
747
0
86006
TrEMBL
other Location (Reliability: 1)
A0A6I8SK15_XENTR
1561
0
175284
TrEMBL
Mitochondrion (Reliability: 2)
A0A803J7D6_XENTR
1066
0
119699
TrEMBL
other Location (Reliability: 1)
A0A803JXJ5_XENTR
998
0
112361
TrEMBL
other Location (Reliability: 2)
A0A1B8Y5M9_XENTR
1019
0
115005
TrEMBL
other Location (Reliability: 5)
A0A6I8T151_XENTR
784
0
89522
TrEMBL
other Location (Reliability: 4)
A0A6I8R934_XENTR
1238
0
140471
TrEMBL
other Location (Reliability: 1)
A0A8J1JK00_XENTR
1649
0
187033
TrEMBL
other Location (Reliability: 1)
A0A8J1JWE5_XENTR
1578
0
176746
TrEMBL
other Location (Reliability: 2)
A0A6I8QEL7_XENTR
1110
0
126395
TrEMBL
other Location (Reliability: 2)
F6VSL4_XENTR
1250
0
142339
TrEMBL
other Location (Reliability: 2)
A0A6I8QC56_XENTR
1167
0
132851
TrEMBL
other Location (Reliability: 1)
A0A8J1JV99_XENTR
2317
0
260330
TrEMBL
other Location (Reliability: 4)
A0A6I8Q238_XENTR
1021
0
114871
TrEMBL
other Location (Reliability: 2)
A0A8J1JXP8_XENTR
2292
0
257612
TrEMBL
other Location (Reliability: 4)
A0A6I8S0U8_XENTR
1274
0
147787
TrEMBL
other Location (Reliability: 2)
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