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Information on EC 3.1.4.11 - phosphoinositide phospholipase C and Organism(s) Taeniopygia guttata

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EC Tree
     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.4 Phosphoric-diester hydrolases
                3.1.4.11 phosphoinositide phospholipase C
IUBMB Comments
These enzymes form some of the cyclic phosphate Ins(cyclic1,2)P(4,5)P2 as well as Ins(1,4,5)P3. They show activity towards phosphatidylinositol, i.e., the activity of EC 4.6.1.13, phosphatidylinositol diacylglycerol-lyase, in vitro at high [Ca2+]. Four beta-isoforms regulated by G-proteins, two gamma-forms regulated by tyrosine kinases, four delta-forms regulated at least in part by calcium and an epsilon-form, probably regulated by the oncogene ras, have been found.
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Taeniopygia guttata
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Word Map
The taxonomic range for the selected organisms is: Taeniopygia guttata
The enzyme appears in selected viruses and cellular organisms
Synonyms
pi-plc, phosphatidylinositol-specific phospholipase c, plc-gamma, plc-gamma1, plcgamma1, plc-beta, plcgamma, phosphoinositide-specific phospholipase c, plcgamma2, phospholipase c-gamma1, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
1-phosphatidyl-D-myo-inositol 4,5-bisphosphate inositoltrisphosphohydrolase
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1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase
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No receptor potential A protein
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phosphatidylinositol 4,5-bisphosphate phosphodiesterase
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phosphatidylinositol-4,5-bisphosphate phosphodiesterase
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phosphatidylinositol-4,5-bisphosphate phospholipase C
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phosphodiesterase, triphosphoinositide
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phosphoinositidase C
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phospholipase C
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phosphotidylinositol 4,5-bisphosphate-specific phospholipase C
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PIC
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PIP2 PDE
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PIP2 phosphodiesterase
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PIPLC
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PLC
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PLC-148
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PLC-154
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PLC-85
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polyphosphoinositide phospholipase C
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PtdIns(4,5)P2-directed phospholipase C
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triphosphoinositide phosphodiesterase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of phosphoric ester
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PATHWAY SOURCE
PATHWAYS
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-, -, -, -, -
SYSTEMATIC NAME
IUBMB Comments
1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase
These enzymes form some of the cyclic phosphate Ins(cyclic1,2)P(4,5)P2 as well as Ins(1,4,5)P3. They show activity towards phosphatidylinositol, i.e., the activity of EC 4.6.1.13, phosphatidylinositol diacylglycerol-lyase, in vitro at high [Ca2+]. Four beta-isoforms regulated by G-proteins, two gamma-forms regulated by tyrosine kinases, four delta-forms regulated at least in part by calcium and an epsilon-form, probably regulated by the oncogene ras, have been found.
CAS REGISTRY NUMBER
COMMENTARY hide
37213-51-7
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
A0A674H5D7_TAEGU
1212
0
138522
TrEMBL
other Location (Reliability: 1)
H0Z557_TAEGU
753
0
86159
TrEMBL
other Location (Reliability: 2)
A0A674HLG2_TAEGU
1027
0
114397
TrEMBL
other Location (Reliability: 1)
H0YQ49_TAEGU
728
0
83877
TrEMBL
other Location (Reliability: 3)
A0A674H4C4_TAEGU
1044
0
117533
TrEMBL
other Location (Reliability: 3)
H0Z1Z9_TAEGU
1223
0
143303
TrEMBL
other Location (Reliability: 2)
A0A674HK96_TAEGU
623
0
71252
TrEMBL
other Location (Reliability: 1)
H0Z304_TAEGU
1282
0
147793
TrEMBL
other Location (Reliability: 2)
A0A674GEJ2_TAEGU
1311
0
152070
TrEMBL
other Location (Reliability: 5)
H0ZJQ3_TAEGU
1018
0
115037
TrEMBL
other Location (Reliability: 3)
H0ZW18_TAEGU
830
0
94256
TrEMBL
Mitochondrion (Reliability: 5)
A0A674HI11_TAEGU
1225
0
136520
TrEMBL
other Location (Reliability: 1)
A0A674HHK0_TAEGU
1124
0
125703
TrEMBL
other Location (Reliability: 1)
A0A674GHY6_TAEGU
1217
0
138864
TrEMBL
other Location (Reliability: 2)
A0A674HPE8_TAEGU
1203
0
136931
TrEMBL
other Location (Reliability: 3)
A0A674GJJ0_TAEGU
1210
0
138615
TrEMBL
other Location (Reliability: 1)
H0ZA90_TAEGU
1306
0
148454
TrEMBL
other Location (Reliability: 5)
A0A674G937_TAEGU
1137
0
132988
TrEMBL
other Location (Reliability: 1)
H0YXJ1_TAEGU
1583
0
175461
TrEMBL
other Location (Reliability: 2)
A0A674HGF7_TAEGU
749
0
86272
TrEMBL
Mitochondrion (Reliability: 3)
A0A674HV66_TAEGU
2331
0
260824
TrEMBL
other Location (Reliability: 2)
A0A674H4W3_TAEGU
1693
0
187085
TrEMBL
other Location (Reliability: 1)
A0A674GGY7_TAEGU
729
0
83740
TrEMBL
other Location (Reliability: 3)
H0ZM21_TAEGU
1725
0
190763
TrEMBL
other Location (Reliability: 2)
H0YY72_TAEGU
1130
0
126508
TrEMBL
other Location (Reliability: 1)
A0A674H125_TAEGU
701
0
80030
TrEMBL
other Location (Reliability: 1)
H0ZQ48_TAEGU
662
0
75832
TrEMBL
other Location (Reliability: 1)
A0A674GJD4_TAEGU
1206
0
137270
TrEMBL
other Location (Reliability: 1)
A0A674GBY1_TAEGU
1281
0
149483
TrEMBL
other Location (Reliability: 2)
H0Z7A6_TAEGU
1117
0
127367
TrEMBL
other Location (Reliability: 1)
H0YWG6_TAEGU
1023
0
113659
TrEMBL
other Location (Reliability: 4)
A0A674H3N6_TAEGU
1025
0
113753
TrEMBL
other Location (Reliability: 2)
H0ZR85_TAEGU
1212
0
139764
TrEMBL
other Location (Reliability: 2)
H0Z7L9_TAEGU
1179
0
134601
TrEMBL
other Location (Reliability: 2)
A0A674G9J6_TAEGU
1101
0
123377
TrEMBL
other Location (Reliability: 2)
H0ZEA7_TAEGU
2317
0
259430
TrEMBL
other Location (Reliability: 2)
A0A674HM85_TAEGU
1222
0
136245
TrEMBL
other Location (Reliability: 3)
A0A674GJH3_TAEGU
1155
0
131925
TrEMBL
other Location (Reliability: 2)
H0ZM24_TAEGU
1713
0
189357
TrEMBL
other Location (Reliability: 1)
A0A674H1M9_TAEGU
637
0
72706
TrEMBL
other Location (Reliability: 1)
A0A674HB27_TAEGU
997
0
112697
TrEMBL
other Location (Reliability: 2)
A0A674GBL5_TAEGU
661
0
75475
TrEMBL
other Location (Reliability: 1)