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Information on EC 3.1.4.11 - phosphoinositide phospholipase C and Organism(s) Caenorhabditis elegans

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EC Tree
     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.4 Phosphoric-diester hydrolases
                3.1.4.11 phosphoinositide phospholipase C
IUBMB Comments
These enzymes form some of the cyclic phosphate Ins(cyclic1,2)P(4,5)P2 as well as Ins(1,4,5)P3. They show activity towards phosphatidylinositol, i.e., the activity of EC 4.6.1.13, phosphatidylinositol diacylglycerol-lyase, in vitro at high [Ca2+]. Four beta-isoforms regulated by G-proteins, two gamma-forms regulated by tyrosine kinases, four delta-forms regulated at least in part by calcium and an epsilon-form, probably regulated by the oncogene ras, have been found.
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Caenorhabditis elegans
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Word Map
The taxonomic range for the selected organisms is: Caenorhabditis elegans
The enzyme appears in selected viruses and cellular organisms
Synonyms
pi-plc, phosphatidylinositol-specific phospholipase c, plc-gamma, plc-gamma1, plcgamma1, plc-beta, plcgamma, phosphoinositide-specific phospholipase c, plcgamma2, phospholipase c-gamma1, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
1-phosphatidyl-D-myo-inositol 4,5-bisphosphate inositoltrisphosphohydrolase
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1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase
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No receptor potential A protein
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phosphatidylinositol 4,5-bisphosphate phosphodiesterase
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phosphatidylinositol-4,5-bisphosphate phosphodiesterase
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phosphatidylinositol-4,5-bisphosphate phospholipase C
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phosphodiesterase, triphosphoinositide
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phosphoinositidase C
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phospholipase C
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phosphotidylinositol 4,5-bisphosphate-specific phospholipase C
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PIC
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PIP2 PDE
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PIP2 phosphodiesterase
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PIPLC
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PLC
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PLC-148
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PLC-154
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PLC-85
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polyphosphoinositide phospholipase C
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PtdIns(4,5)P2-directed phospholipase C
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triphosphoinositide phosphodiesterase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of phosphoric ester
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PATHWAY SOURCE
PATHWAYS
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-, -, -, -, -
SYSTEMATIC NAME
IUBMB Comments
1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase
These enzymes form some of the cyclic phosphate Ins(cyclic1,2)P(4,5)P2 as well as Ins(1,4,5)P3. They show activity towards phosphatidylinositol, i.e., the activity of EC 4.6.1.13, phosphatidylinositol diacylglycerol-lyase, in vitro at high [Ca2+]. Four beta-isoforms regulated by G-proteins, two gamma-forms regulated by tyrosine kinases, four delta-forms regulated at least in part by calcium and an epsilon-form, probably regulated by the oncogene ras, have been found.
CAS REGISTRY NUMBER
COMMENTARY hide
37213-51-7
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
PLCB_CAEEL
1431
0
160904
Swiss-Prot
other Location (Reliability: 2)
PLCE1_CAEEL
1898
0
212879
Swiss-Prot
Mitochondrion (Reliability: 4)
PLCG_CAEEL
1350
0
154574
Swiss-Prot
Mitochondrion (Reliability: 3)
A0A0K3AXJ6_CAEEL
1366
0
153747
TrEMBL
other Location (Reliability: 2)
A0A0K3AXJ0_CAEEL
1484
0
166196
TrEMBL
other Location (Reliability: 2)
G5EFG8_CAEEL
1886
0
211017
TrEMBL
other Location (Reliability: 3)
A0A0K3AUL7_CAEEL
1334
0
151487
TrEMBL
other Location (Reliability: 2)
A0A0K3AS90_CAEEL
1225
0
139333
TrEMBL
other Location (Reliability: 2)
A0A0K3AXK2_CAEEL
1237
0
140742
TrEMBL
other Location (Reliability: 2)
A0A0K3ARR7_CAEEL
1391
0
156065
TrEMBL
other Location (Reliability: 2)
A0A0K3AS71_CAEEL
1500
0
168218
TrEMBL
other Location (Reliability: 2)
A0A0K3ARR2_CAEEL
1265
0
144173
TrEMBL
other Location (Reliability: 2)
A0A0K3ARS4_CAEEL
1318
0
149465
TrEMBL
other Location (Reliability: 2)
A0A0K3AV97_CAEEL
1378
0
155156
TrEMBL
other Location (Reliability: 2)
A0A0K3AV92_CAEEL
1253
0
142765
TrEMBL
other Location (Reliability: 2)
A0A0K3AS85_CAEEL
1297
0
146433
TrEMBL
other Location (Reliability: 2)
A0A0K3AV83_CAEEL
1325
0
149864
TrEMBL
other Location (Reliability: 2)
A0A0K3AS80_CAEEL
1472
0
164787
TrEMBL
other Location (Reliability: 2)
Q8IA75_CAEEL
1075
1
121112
TrEMBL
other Location (Reliability: 2)
A0A0K3AUL3_CAEEL
1406
0
158587
TrEMBL
other Location (Reliability: 2)
A0A0K3AUM3_CAEEL
1403
0
157473
TrEMBL
other Location (Reliability: 2)
A0A0K3AXH8_CAEEL
1512
0
169627
TrEMBL
other Location (Reliability: 2)
A0A0K3AS74_CAEEL
1346
0
152896
TrEMBL
other Location (Reliability: 2)
Q9XWB7_CAEEL
896
0
103804
TrEMBL
other Location (Reliability: 1)
A0A0K3AVA5_CAEEL
1306
0
148056
TrEMBL
other Location (Reliability: 2)
A0A0K3AXI3_CAEEL
1313
0
148456
TrEMBL
other Location (Reliability: 2)
A0A0K3AUN1_CAEEL
1285
0
145025
TrEMBL
other Location (Reliability: 2)
Q21754_CAEEL
751
0
85869
TrEMBL
other Location (Reliability: 1)
Q8IA76_CAEEL
1068
0
120043
TrEMBL
other Location (Reliability: 1)
A0A0K3ARQ7_CAEEL
1394
0
157178
TrEMBL
other Location (Reliability: 2)