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Information on EC 3.1.3.96 - pseudouridine 5'-phosphatase and Organism(s) Homo sapiens

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EC Tree
     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.3 Phosphoric-monoester hydrolases
                3.1.3.96 pseudouridine 5'-phosphatase
IUBMB Comments
Requires Mg2+ for activity.
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This record set is specific for:
Homo sapiens
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Word Map
The taxonomic range for the selected organisms is: Homo sapiens
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
hdhd1, haloacid dehalogenase-like hydrolase domain-containing 1, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5'-PsiMPase
haloacid dehalogenase-like hydrolase domain-containing 1
-
-
HDHD1
pseudouridine 5'-monophosphatase
SYSTEMATIC NAME
IUBMB Comments
pseudouridine 5'-phosphohydrolase
Requires Mg2+ for activity.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
pseudouridine 5'-phosphate + H2O
pseudouridine + phosphate
show the reaction diagram
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
pseudouridine 5'-phosphate + H2O
pseudouridine + phosphate
show the reaction diagram
-
-
-
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
-
required for activity
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Ca2+
-
-
pseudouridine
-
-
vanadate
-
-
additional information
-
not inhibited by 5'-UMP at a concentration of 0.3 mM, 1-methylpseudouridine barely inhibits, no inhibition with uridine and adenosine
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00038
pseudouridine 5'-phosphate
-
pH 7.1, 30°C
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1.6
pseudouridine 5'-phosphate
-
pH 7.1, 30°C
kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
4184
pseudouridine 5'-phosphate
-
pH 7.1, 30°C
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.1
-
assay at
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
30
-
assay at
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
pseudouridine-5'-phosphatase activity is 1.5-fold higher in erythrocytes from women compared with men
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
-
X-linked ichthyosis patients harbour a combined deletion of the STS gene (the X-linked ichthyosis gene) and the HDHD1 gene
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
HDHD1_HUMAN
228
0
25249
Swiss-Prot
other Location (Reliability: 4)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
26000
-
gel filtration
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
partial
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Preumont, A.; Rzem, R.; Vertommen, D.; Van Schaftingen, E.
HDHD1, which is often deleted in X-linked ichthyosis, encodes a pseudouridine-5-phosphatase
Biochem. J.
431
237-244
2010
Homo sapiens
Manually annotated by BRENDA team