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Information on EC 3.1.3.95 - phosphatidylinositol-3,5-bisphosphate 3-phosphatase and Organism(s) Mus musculus

for references in articles please use BRENDA:EC3.1.3.95
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EC Tree
IUBMB Comments
The enzyme is found in both plants and animals. It also has the activity of EC 3.1.3.64 (phosphatidylinositol-3-phosphatase).
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This record set is specific for:
Mus musculus
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Word Map
The taxonomic range for the selected organisms is: Mus musculus
The enzyme appears in selected viruses and cellular organisms
Synonyms
myotubularin-related protein 3, myotubularin-related protein 14, myotubularin-related protein-4, myotubularin-related protein 1, myotubularin related protein-2, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
MTMR14
-
-
myotubularin-related protein 14
-
-
PATHWAY SOURCE
PATHWAYS
-
-
SYSTEMATIC NAME
IUBMB Comments
1-phosphatidyl-1D-myo-inositol-3,5-bisphosphate 3-phosphohydrolase
The enzyme is found in both plants and animals. It also has the activity of EC 3.1.3.64 (phosphatidylinositol-3-phosphatase).
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + H2O
1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate
show the reaction diagram
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O
1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate
show the reaction diagram
1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O
1-phosphatidyl-1D-myo-inositol + phosphate
show the reaction diagram
4fold lower rate of dephosphorylation compared with 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
?
show the reaction diagram
-
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + H2O
1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate
show the reaction diagram
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O
1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate
show the reaction diagram
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
?
show the reaction diagram
-
-
-
-
?
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
particularly high expression
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
-
isoform MTMR14 deletion induces overweight and adult obesity accompanied by chronic inflammation in an age-dependent manner
physiological function
mutations in the gene encoding myotubularin-related protein MTMR2 are responsible for autosomal recessive Charcot-Marie-Tooth disease type 4B1. The known disease-associated MTMR2 mutations lead to dramatically reduced phosphatase activity
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
MTMR1_MOUSE
669
0
75313
Swiss-Prot
other Location (Reliability: 3)
MTMR2_MOUSE
643
0
73232
Swiss-Prot
other Location (Reliability: 2)
MTMR3_MOUSE
1196
0
133840
Swiss-Prot
other Location (Reliability: 1)
MTMR6_MOUSE
617
0
70933
Swiss-Prot
other Location (Reliability: 2)
MTM1_MOUSE
603
0
69559
Swiss-Prot
other Location (Reliability: 2)
Q3TLK7_MOUSE
586
0
67592
TrEMBL
other Location (Reliability: 2)
Q5DU01_MOUSE
424
0
49222
TrEMBL
Secretory Pathway (Reliability: 4)
I7HJQ9_MOUSE
671
0
75541
TrEMBL
other Location (Reliability: 3)
Q9D4L1_MOUSE
603
0
69375
TrEMBL
other Location (Reliability: 2)
Q3V030_MOUSE
571
0
65754
TrEMBL
other Location (Reliability: 1)
B1AW21_MOUSE
572
0
65963
TrEMBL
other Location (Reliability: 2)
Q6P572_MOUSE
571
0
65768
TrEMBL
other Location (Reliability: 1)
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
DELTAF494-E531
recessive Charcot-Marie-Tooth disease type 4B1 related mutation, almost complete loss of activity
E276X
recessive Charcot-Marie-Tooth disease type 4B1 related mutation, almost complete loss of activity
G103E
less than 5% residual activity
Q426X
recessive Charcot-Marie-Tooth disease type 4B1 related mutation, almost complete loss of activity
Q482X
recessive Charcot-Marie-Tooth disease type 4B1 related mutation, almost complete loss of activity
Y579Stop
recessive Charcot-Marie-Tooth disease type 4B1 related mutation, almost complete loss of activity
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Berger, P.; Bonneick, S.; Willi, S.; Wymann, M.; Suter, U.
Loss of phosphatase activity in myotubularin-related protein 2 is associated with Charcot-Marie-Tooth disease type 4B1
Hum. Mol. Genet.
11
1569-1579
2002
Mus musculus (Q9Z2D1)
Manually annotated by BRENDA team
Lv, Y.; Xue, L.; Cai, C.; Liu, Q.H.; Shen, J.
Deficiency of myotubularin-related protein 14 influences body weight, metabolism, and inflammation in an age-dependent manner
Cell Biosci.
5
69
2015
Mus musculus
Manually annotated by BRENDA team