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Information on EC 3.1.3.86 - phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase and Organism(s) Arabidopsis thaliana

for references in articles please use BRENDA:EC3.1.3.86
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EC Tree
IUBMB Comments
This enzyme hydrolyses 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. The enzyme also shows activity toward (PtdIns(1,3,4,5)P4) . The enzyme is involved in several signal transduction pathways in the immune system leading to an adverse range of effects.
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This record set is specific for:
Arabidopsis thaliana
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The taxonomic range for the selected organisms is: Arabidopsis thaliana
The enzyme appears in selected viruses and cellular organisms
Synonyms
ship-1, ship-2, inpp5d, inppl1, 5'-inositol phosphatase, sh2-containing inositol phosphatase, sh2 domain-containing inositol 5-phosphatase, ptdins(3,4,5)p3 5-phosphatase, phosphatidylinositol 5-phosphatase, pi 5-phosphatase, more
PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 5-phosphohydrolase
This enzyme hydrolyses 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. The enzyme also shows activity toward (PtdIns(1,3,4,5)P4) [5]. The enzyme is involved in several signal transduction pathways in the immune system leading to an adverse range of effects.
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
IP5P7_ARATH
594
0
68245
Swiss-Prot
other Location (Reliability: 3)
IP5P9_ARATH
417
0
47924
Swiss-Prot
Mitochondrion (Reliability: 5)
IP5PB_ARATH
334
0
37580
Swiss-Prot
Chloroplast (Reliability: 5)
IP5PE_ARATH
1144
0
125708
Swiss-Prot
other Location (Reliability: 3)
IP5PF_ARATH
1101
0
121711
Swiss-Prot
other Location (Reliability: 4)
IP5P3_ARATH
664
0
74780
Swiss-Prot
other Location (Reliability: 4)
IP5P6_ARATH
617
0
70853
Swiss-Prot
other Location (Reliability: 4)