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EC Tree
IUBMB Comments Also acts on 3'-phosphoadenylyl sulfate, and on the corresponding 2'-phosphates.
The taxonomic range for the selected organisms is: Homo sapiens The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
papase, pap phosphatase, bpnt1, rv2837c, fiery1,
met22 , 3'(2'),5'-bisphosphate nucleotidase, gpapp, bpnt-1, bpntase,
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3'(2'),5'-bisphosphate nucleotidase 1
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3'(2'),5'-bisphosphonucleoside 3'(2')-phosphohydrolase
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3'(2'),5-bisphosphonucleoside 3'(2')-phosphohydrolase
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3'(2')-phosphoadenosine 5-phosphate phosphatase
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3'-phosphoadenylylsulfate 3'-phosphatase
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adenosine-3',5'-bisphosphate 3'-phosphohydrolase
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bisphosphate 3'-nucleotidase
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Halotolerance protein tol1
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nucleotidase, phosphoadenylate 3'-
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phosphoadenylate 3'-nucleotidase
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hydrolysis of phosphoric ester
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adenosine-3'(2'),5'-bisphosphate 3'(2')-phosphohydrolase
Also acts on 3'-phosphoadenylyl sulfate, and on the corresponding 2'-phosphates.
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adenosine 2',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
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adenosine 3',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
inositol-1,4-bisphosphate + H2O
inositol 4-phosphate + phosphate
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additional information
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the enzyme mediates lithium toxicity effects
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adenosine 3',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
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adenosine 3',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
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adenosine 3',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
the activity of enzyme is required while 3'-phosphoadenosine 5'-phosphate is a potent inhibitor of a variety of enzymes that use 3'-phosphoadenosine 5'-phosphate as cosubstrate
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adenosine 3',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
the activity of enzyme is required while 3'-phosphoadenosine 5'-phosphate is a potent inhibitor of a variety of enzymes that use 3'-phosphoadenosine 5'-phosphate as cosubstrate
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additional information
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the enzyme mediates lithium toxicity effects
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Mg2+
required, optimal concentration of 1 mM
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inositol 1,4-bisphosphate
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3'(2'),5'-bisphosphate nucleotidase deficiency
Chondrodysplasia and abnormal joint development associated with mutations in IMPAD1, encoding the Golgi-resident nucleotide phosphatase, gPAPP.
Anemia
A longitudinal study of red cell enzymes in infants of low birth weight.
Anemia
Modulation of sulfur assimilation metabolic toxicity overcomes anemia and hemochromatosis in mice.
Anemia, Iron-Deficiency
Modulation of intestinal sulfur assimilation metabolism regulates iron homeostasis.
Anemia, Iron-Deficiency
Modulation of sulfur assimilation metabolic toxicity overcomes anemia and hemochromatosis in mice.
Brachydactyly
IMPAD1 mutations in two Catel-Manzke like patients.
Cleft Palate
IMPAD1 mutations in two Catel-Manzke like patients.
Dwarfism
A role for a lithium-inhibited Golgi nucleotidase in skeletal development and sulfation.
Hemochromatosis
Modulation of sulfur assimilation metabolic toxicity overcomes anemia and hemochromatosis in mice.
Hyaline Membrane Disease
Fetal lung maturation: human amniotic fluid phosphatidate phosphohydrolase activity through normal gestation and its relation to the lecithin/sphingomyelin ratio.
Hypoproteinemia
Role for cytoplasmic nucleotide hydrolysis in hepatic function and protein synthesis.
Jaundice, Neonatal
A longitudinal study of red cell enzymes in infants of low birth weight.
Joint Dislocations
IMPAD1 mutations in two Catel-Manzke like patients.
Liver Failure
Tissue-specific regulation of 3'-nucleotide hydrolysis and nucleolar architecture.
Pulmonary Atelectasis
A role for a lithium-inhibited Golgi nucleotidase in skeletal development and sulfation.
Squamous Cell Carcinoma of Head and Neck
Subpath analysis of each subtype of head and neck cancer based on the regulatory relationship between miRNAs and biological pathways.
Trismus
Double-blind study of prednisolone and papase as inhibitors of complications after oral surgery.
Tuberculosis
Characterization of NrnA homologs from Mycobacterium tuberculosis and Mycoplasma pneumoniae.
Tuberculosis
Mechanism of Rv2837c from Mycobacterium tuberculosis remains controversial.
Tuberculosis
Reply to Valadares and Woo: Mechanism of Rv2837c from Mycobacterium tuberculosis remains controversial.
Tuberculosis
Rv2131c from Mycobacterium tuberculosis is a CysQ 3'-phosphoadenosine-5'-phosphatase.
Tuberculosis
Rv2131c gene product: an unconventional enzyme that is both inositol monophosphatase and fructose-1,6-bisphosphatase.
Tuberculosis
Structural and Biochemical Insight into the Mechanism of Rv2837c from Mycobacterium tuberculosis as a c-di-NMP Phosphodiesterase.
Tuberculosis
Structural and biochemical insight into the mechanism of Rv2837c from Mycobacterium tuberculosis as a c-di-NMP phosphodiesterase.
Tuberculosis
The Mycobacterium tuberculosis CysQ phosphatase modulates the biosynthesis of sulfated glycolipids and bacterial growth.
Whooping Cough
Effect of light on phosphatidate phosphohydrolase activity of retina rod outer segments: the role of transducin.
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0.001
adenosine 3',5'-bisphosphate
pH 7.5, 30°C
0.0004
inositol-1,4-bisphosphate
pH 7.5, 30°C
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0.3
Li+
pH 7.5, 30°C, substrate: adenosine 3,5-bisphosphate
0.6
Li+
pH 7.5, 30°C, substrate: inositol-1,4-bisphosphate
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SwissProt
brenda
GenBank AF125042
SwissProt
brenda
recombinantly expressed in yeast
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brenda
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in glioma tissues, phosphocholine(36:1) is not detected and 3'-phosphoadenylate (pAp) content is significantly increased. The gene expression of the 3'-nucleotidase 3'(2'),5'-bisphosphate nucleotidase 1 (BPNT-1) is dramatically downregulated, quantitative real-time polymerase chain reaction (qRT-PCR) expression analysis. Gene expression of enzymes associated with pAp metabolism
brenda
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malfunction
in glioma tissues, glycerophosphatidylcholine [PC(36:1)] is not detected and 3'-phosphoadenylate (pAp) content is significantly increased. The gene expressions of 3'-nucleotidases inositol monophosphatase (IMPAD-1) and 3'(2'),5'-bisphosphate nucleotidase 1 (BPNT-1)) are dramatically downregulated. Dramatic downregulation of IMPAD-1 and BPNT-1 are the primary cause for pAp dramatic accumulation
physiological function
Gene expression of enzymes associated with 3'-phosphoadenylate (pAp) metabolism, pAp is a toxic by-product
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BPNT1_HUMAN
308
0
33392
Swiss-Prot
Mitochondrion (Reliability: 4 )
IMPA3_HUMAN
359
1
38681
Swiss-Prot
Secretory Pathway (Reliability: 1 )
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cloning of HsPIP and expression in Escherichia coli
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in glioma tissues, glycerophosphatidylcholine [PC(36:1)] is not detected and 3'-phosphoadenylate content is significantly increased. The gene expression of the 3'-nucleotidase 3'(2'),5'-bisphosphate nucleotidase 1 (BPNT-1) is dramatically downregulated
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medicine
enzyme as a potential target of lithium therapy
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Spiegelberg, B.D.; Xiong, J.P.; Smith, J.J.; Gu, R.F.; York, J.D.
Cloning and characterization of a mammalian lithium-sensitive bisphosphate 3-nucleotidase inhibited by inositol 1,4-bisphosphate
J. Biol. Chem.
274
13619-13628
1999
Homo sapiens (O95861), Homo sapiens, Mus musculus (Q9Z0S1), Mus musculus
brenda
Yenush, L.; Belles, J.M.; Lopez-Coronado, J.M.; Gil-Mascarell, R.; Serrano, R.; Rodriguez, P.L.
A novel target of lithium therapy
FEBS Lett.
467
321-325
2000
Homo sapiens (O95861), Homo sapiens
brenda
Spiegelberg, B.D.; Dela Cruz, J.; Law, T.H.; York, J.D.
Alteration of lithium pharmacology through manipulation of phosphoadenosine phosphate metabolism
J. Biol. Chem.
280
5400-5405
2005
Homo sapiens
brenda
Li, W.; Jia, H.; Li, Q.; Cui, J.; Li, R.; Zou, Z.; Hong, X.
Glycerophosphatidylcholine PC(36 1) absence and 3'-phosphoadenylate (pAp) accumulation are hallmarks of the human glioma metabolome
Sci. Rep.
8
14783
2018
Homo sapiens (O95861), Homo sapiens
brenda