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Acquired Immunodeficiency Syndrome
mTOR activity in AIDS-related diffuse large B-cell lymphoma.
Acute Kidney Injury
Xenon Protects Against Septic Acute Kidney Injury via miR-21 Target Signaling Pathway.
Adenocarcinoma
Absence of PTEN/MMAC1 gene mutations in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats.
Adenocarcinoma
Activation of Mammalian Target of Rapamycin Signaling Pathway Markers in Minute Adenocarcinoma of the Prostate.
Adenocarcinoma
Construction and analysis of three networks of genes and microRNAs in adenocarcinoma.
Adenocarcinoma
Expression of FAK and PTEN in Bronchioloalveolar carcinoma and lung adenocarcinoma.
Adenocarcinoma
Expression of phosphatase and tensin homologue in imprint smears of endometrial carcinoma.
Adenocarcinoma
Expression of PTEN in ovarian epithelial tumors and its relation to tumor behavior and growth.
Adenocarcinoma
Expression of PTEN, Androgen Receptor, HER2/neu, Cytokeratin 5/6, Estrogen Receptor-Beta, HMGA2, and PLAG1 in Salivary Duct Carcinoma.
Adenocarcinoma
Expression Profiles of the Phosphatase and Tensin Homolog (PTEN), CDH1, and CDH2 Genes, and the Cell Membrane Protein, CD133, in the Ishikawa Human Endometrial Adenocarcinoma Cell Line.
Adenocarcinoma
Histologic-Type Specific Role of Cell Cycle Regulators in Non-Small Cell Lung Carcinoma.
Adenocarcinoma
JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate.
Adenocarcinoma
Loss of phosphatase and tensin homolog expression is associated with recurrence and poor prognosis in patients with pancreatic ductal adenocarcinoma.
Adenocarcinoma
Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in advanced gastric carcinomas.
Adenocarcinoma
Proteomic and transcriptomic profiling of Pten gene-knockout mouse model of prostate cancer.
Adenocarcinoma
PTEN alterations of the stromal cells characterise an aggressive subpopulation of pancreatic cancer with enhanced metastatic potential.
Adenocarcinoma
PTEN Expression in Mucinous Prostatic Adenocarcinoma, Prostatic Adenocarcinoma With Mucinous Features, and Adjacent Conventional Prostatic Adenocarcinoma: A Multi-institutional Study of 92 Cases.
Adenocarcinoma
PTEN Expression in Mucinous Prostatic Adenocarcinoma, Prostatic Adenocarcinoma With Mucinous Features, and Adjacent Conventional Prostatic Adenocarcinoma: A Multiinstitutional Study of 92 Cases.
Adenocarcinoma
PTEN is a predictive biomarker of trastuzumab resistance and prognostic factor in HER2-overexpressing gastroesophageal adenocarcinoma.
Adenocarcinoma
PTEN promoter methylation and LOH of 10q22-23 locus in PTEN expression of ovarian clear cell adenocarcinomas.
Adenocarcinoma
The mTOR pathway is frequently activated in pancreatic ductal adenocarcinoma and chronic pancreatitis.
Adenocarcinoma
Utilization of Unlabeled Probes for the Detection of Fibroblast Growth Factor Receptor 2 Exons 7 and 12 Mutations in Endometrial Carcinoma.
Adenocarcinoma of Lung
Absence of PTEN/MMAC1 gene mutations in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats.
Adenocarcinoma of Lung
Loss of Phosphatase and Tensin Homolog Protein Expression Is an Independent Poor Prognostic Marker in Lung Adenocarcinoma.
Adenocarcinoma of Lung
MicroRNA-181a regulates epithelial-mesenchymal transition by targeting PTEN in drug-resistant lung adenocarcinoma cells.
Adenocarcinoma, Clear Cell
PTEN promoter methylation and LOH of 10q22-23 locus in PTEN expression of ovarian clear cell adenocarcinomas.
Adenocarcinoma, Follicular
A case of follicular thyroid carcinoma associated with phosphatase and tensin homologue hamartoma tumour syndrome.
Adenocarcinoma, Follicular
Mutation analysis of PTEN/MMAC 1 in sporadic thyroid tumors.
Adenoma
An Immunohistochemical Study of the PTEN/AKT Pathway Involvement in Canine and Feline Mammary Tumors.
Adenoma
Mutational abrogation of the PTEN/MMAC1 gene in gastrointestinal polyps in patients with Cowden disease.
Adenoma, Pleomorphic
Expression of PTEN, Androgen Receptor, HER2/neu, Cytokeratin 5/6, Estrogen Receptor-Beta, HMGA2, and PLAG1 in Salivary Duct Carcinoma.
Adenomatous Polyposis Coli
Beyond Trophic Factors: Exploiting the Intrinsic Regenerative Properties of Adult Neurons.
Adenomatous Polyposis Coli
Clofarabine, a novel adenosine analogue, reactivates DNA methylation-silenced tumour suppressor genes and inhibits cell growth in breast cancer cells.
Adenomatous Polyposis Coli
Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein.
Adenomatous Polyposis Coli
Genistein inhibits DNA methylation and increases expression of tumor suppressor genes in human breast cancer cells.
Adenomatous Polyposis Coli
Hotspot Mutations Detectable by Next-generation Sequencing in Exhaled Breath Condensates from Patients with Lung Cancer.
Adenomatous Polyposis Coli
[Hereditary colorectal cancer : An update on genetics and entities in terms of differential diagnosis].
Albuminuria
Therapeutic miR-21 Silencing Ameliorates Diabetic Kidney Disease in Mice.
Alzheimer Disease
A pilot study on the effect of lactoferrin on Alzheimer's disease pathological sequelae: Impact of the p-Akt/PTEN pathway.
Alzheimer Disease
PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis.
Ameloblastoma
Expression and alterations of the PTEN / AKT / mTOR pathway in ameloblastomas.
Ameloblastoma
Role of phosphatase and tensin homolog in pathogenesis of ameloblastoma: An immunohistochemical study.
Aneurysm
MicroRNA-21 Blocks Abdominal Aortic Aneurysm Development and Nicotine-Augmented Expansion.
Aortic Aneurysm, Abdominal
MicroRNA-29a-3p regulates abdominal aortic aneurysm development and progression via direct interaction with PTEN.
Arthritis
Phosphatase and tensin homolog (PTEN) in antigen-presenting cells controls Th17-mediated autoimmune arthritis.
Arthritis, Rheumatoid
PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis.
Asthma
PTEN down-regulates IL-17 expression in a murine model of toluene diisocyanate-induced airway disease.
Asthma
PTEN participates in airway remodeling of asthma by regulating CD38/Ca2+/CREB signaling.
Astrocytoma
Akt-dependent proapoptotic effects of dietary restriction on late-stage management of a phosphatase and tensin homologue/tuberous sclerosis complex 2-deficient mouse astrocytoma.
Astrocytoma
Distinct patterns of deletion on 10p and 10q suggest involvement of multiple tumor suppressor genes in the development of astrocytic gliomas of different malignancy grades.
Astrocytoma
Expression of phosphatase and tensin homolog, epidermal growth factor receptor, and Ki-67 in astrocytoma: A prospective study in a tertiary care hospital.
Astrocytoma
Inhibition of ILK in PTEN-mutant human glioblastomas inhibits PKB/Akt activation, induces apoptosis, and delays tumor growth.
Astrocytoma
miR-21 Is Linked to Glioma Angiogenesis: A Co-Localization Study.
Astrocytoma
Molecular diagnostics of gliomas using next generation sequencing of a glioma-tailored gene panel.
Astrocytoma
Pilocytic astrocytoma presenting as primary diffuse leptomeningeal gliomatosis: report of a unique case and review of the literature.
Astrocytoma
Retinal astrocytoma in a young male with PTEN hamartoma tumor syndrome.
Astrocytoma
S1P(2) receptors mediate inhibition of glioma cell migration through Rho signaling pathways independent of PTEN.
Ataxia
Multifocal demyelinating motor neuropathy and hamartoma syndrome associated with a de novo PTEN mutation.
Ataxia Telangiectasia
Genistein inhibits DNA methylation and increases expression of tumor suppressor genes in human breast cancer cells.
Ataxia Telangiectasia
Theasaponin E1 Inhibits Platinum-Resistant Ovarian Cancer Cells through Activating Apoptosis and Suppressing Angiogenesis.
Atherosclerosis
Association of PTEN genetic polymorphisms with atherosclerotic cerebral infarction in the Han Chinese population.
Atherosclerosis
Increased stability of phosphatase and tensin homolog by intermedin leading to scavenger receptor A inhibition of macrophages reduces atherosclerosis in apolipoprotein E-deficient mice.
Atherosclerosis
LncRNA UCA1 sponges miR-26a to regulate the migration and proliferation of vascular smooth muscle cells.
Atherosclerosis
MiR-106b-5p Inhibits Tumor Necrosis Factor-?-induced Apoptosis by Targeting Phosphatase and Tensin Homolog Deleted on Chromosome 10 in Vascular Endothelial Cells.
Autoimmune Diseases
Fibrosis caused by loss of PTEN expression by fibroblasts is crucially dependent on CCN2.
Azoospermia
The expression of microRNAs and exposure to environmental contaminants related to human health: a review.
Bacterial Infections
Myeloid PTEN promotes inflammation but impairs bactericidal activities during murine pneumococcal pneumonia.
Blister
PIP3 depletion rescues myoblast fusion defects in human rhabdomyosarcoma cells.
Bone Marrow Failure Disorders
Pivotal role of Pten in the balance between proliferation and differentiation of hematopoietic stem cells in zebrafish.
Brain Injuries
Administration of a PTEN inhibitor BPV(pic) attenuates early brain injury via modulating AMPA receptor subunits after subarachnoid hemorrhage in rats.
Brain Injuries, Traumatic
Bisperoxovanadium mediates neuronal protection through inhibition of PTEN and activation of PI3K/AKT-mTOR signaling following traumatic spinal injuries.
Brain Injuries, Traumatic
Inhibition of phosphatase and tensin homolog deleted on chromosome 10 decreases rat cortical neuron injury and blood-brain barrier permeability, and improves neurological functional recovery in traumatic brain injury model.
Brain Ischemia
Unique properties of PTEN-L contribute to neuroprotection in response to ischemic-like stress.
Brain Neoplasms
A curcumin-loaded polymeric micelle as a carrier of a microRNA-21 antisense-oligonucleotide for enhanced anti-tumor effects in a glioblastoma animal model.
Brain Neoplasms
Deregulation of a STAT3-interleukin 8 signaling pathway promotes human glioblastoma cell proliferation and invasiveness.
Brain Neoplasms
Genetic alterations of the tumor suppressor gene PTEN/MMAC1 in human brain metastases.
Brain Neoplasms
Hereditary breast cancer associated with Cowden syndrome-related PTEN mutation with Lhermitte-Duclos disease.
Brain Neoplasms
Mechanisms of Disease: the PI3K-Akt-PTEN signaling node--an intercept point for the control of angiogenesis in brain tumors.
Brain Neoplasms
Targeting the mTOR pathway using novel ATP?competitive inhibitors, Torin1, Torin2 and XL388, in the treatment of glioblastoma.
Brain Neoplasms
The catalytic phosphoinositol 3-kinase isoform p110? is required for glioma cell migration and invasion.
Brain Neoplasms
Why is PTEN an important tumor suppressor?
Brain Neoplasms
[Expression of epidermal growth factor receptor and PTEN in malignancy brain tumors]
Breast Neoplasms
4-Hydroxynonenal promotes growth and angiogenesis of breast cancer cells through HIF-1? stabilization.
Breast Neoplasms
A novel functional interplay between Progesterone Receptor-B and PTEN, via AKT, modulates autophagy in breast cancer cells.
Breast Neoplasms
A study of the PTEN/MMAC1 gene in 136 breast cancer families.
Breast Neoplasms
A study on promoter methylation of PTEN in sporadic breast cancer patients from North India.
Breast Neoplasms
Aberrant promoter methylation of cancer-related genes in human breast cancer.
Breast Neoplasms
Addition of the p110? inhibitor BYL719 overcomes targeted therapy resistance in cells from Her2-positive-PTEN-loss breast cancer.
Breast Neoplasms
An integrative analysis of PIK3CA mutation, PTEN, and INPP4B expression in terms of trastuzumab efficacy in HER2-positive breast cancer.
Breast Neoplasms
Association of phosphatase and tensin homolog low and phosphatidylinositol 3-kinase catalytic subunit alpha gene mutations on outcome in human epidermal growth factor receptor 2-positive metastatic breast cancer patients treated with first-line lapatinib plus paclitaxel or paclitaxel alone.
Breast Neoplasms
Association of Single-Nucleotide Polymorphisms in Monoubiquitinated FANCD2-DNA Damage Repair Pathway Genes With Breast Cancer in the Chinese Population.
Breast Neoplasms
BAG5 regulates PTEN stability in MCF-7 cell line.
Breast Neoplasms
Benefit to neoadjuvant anti-human epidermal growth factor receptor 2 (HER2)-targeted therapies in HER2-positive primary breast cancer is independent of phosphatase and tensin homolog deleted from chromosome 10 (PTEN) status.
Breast Neoplasms
Brown Seaweed Fucoidan Inhibits Cancer Progression by Dual Regulation of mir-29c/ADAM12 and miR-17-5p/PTEN Axes in Human Breast Cancer Cells.
Breast Neoplasms
Characterization of ovarian clear cell carcinoma using target drug-based molecular biomarkers: implications for personalized cancer therapy.
Breast Neoplasms
Clofarabine, a novel adenosine analogue, reactivates DNA methylation-silenced tumour suppressor genes and inhibits cell growth in breast cancer cells.
Breast Neoplasms
Comparative effects of retinoic acid, vitamin D and resveratrol alone and in combination with adenosine analogues on methylation and expression of phosphatase and tensin homologue tumour suppressor gene in breast cancer cells.
Breast Neoplasms
Correlation Between Onco-suppressors PTEN and NM23 and Clinical Outcome in Patients With T1 Breast Cancer.
Breast Neoplasms
Deletion of PTEN promotes tumorigenic signaling, resistance to anoikis, and altered response to chemotherapeutic agents in human mammary epithelial cells.
Breast Neoplasms
Development of the CK-MB-1 trastuzumab-resistant HER2-positive breast cancer cell line and xenograft animal models.
Breast Neoplasms
Diagnostic potential of PTEN-targeting miR-214 in the blood of breast cancer patients.
Breast Neoplasms
DNA damage repair in breast cancer and its therapeutic implications.
Breast Neoplasms
Estrogen receptor ? induces down-regulation of PTEN through PI3-kinase activation in breast cancer cells.
Breast Neoplasms
Evaluation of Methods for Preserving PTEN Antigenicity in Stored Paraffin Sections.
Breast Neoplasms
Exogenous PTEN gene induces apoptosis in breast carcinoma cell line MDA468.
Breast Neoplasms
Exploiting Chromosomal Instability of PTEN-Deficient Triple-Negative Breast Cancer Cell Lines for the Sensitization against PARP1 Inhibition in a Replication-Dependent Manner.
Breast Neoplasms
Expression of PIK3CA, PTEN mRNA and PIK3CA mutations in primary breast cancer: association with lymph node metastases.
Breast Neoplasms
Expression of PTEN, cyclin D1, P27/KIP1 in invasive ductal carcinomas of the breast and correlation with clinicopathological parameters.
Breast Neoplasms
Functional genomics identifies specific vulnerabilities in PTEN-deficient breast cancer.
Breast Neoplasms
Global Analysis of miRNA-mRNA Interaction Network in Breast Cancer with Brain Metastasis.
Breast Neoplasms
Hereditary breast cancer.
Breast Neoplasms
Immunohistochemical prediction of lapatinib efficacy in advanced HER2-positive breast cancer patients.
Breast Neoplasms
In vivo longitudinal imaging of RNA interference-induced endocrine therapy resistance in breast cancer.
Breast Neoplasms
Increased PTEN expression due to transcriptional activation of PPARgamma by Lovastatin and Rosiglitazone.
Breast Neoplasms
Infrequent mutations in the PTEN/MMAC1 gene among primary breast cancers.
Breast Neoplasms
INPP4B and PTEN Loss Leads to PI-3,4-P2 Accumulation and Inhibition of PI3K in TNBC.
Breast Neoplasms
Integrated Analysis of PTEN and p4EBP1 Protein Expression as Predictors for pCR in HER2-Positive Breast Cancer.
Breast Neoplasms
Loss of Phosphatase and Tensin Homologue Deleted on Chromosome 10 Engages ErbB3 and Insulin-Like Growth Factor-I Receptor Signaling to Promote Antiestrogen Resistance in Breast Cancer.
Breast Neoplasms
Mechanism of action studies of lomaiviticin A and the monomeric lomaiviticin aglycon. Selective and potent activity toward DNA double-strand break repair-deficient cell lines.
Breast Neoplasms
Metformin and the mTOR inhibitor everolimus (RAD001) sensitize breast cancer cells to the cytotoxic effect of chemotherapeutic drugs in vitro.
Breast Neoplasms
Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis.
Breast Neoplasms
MicroRNA-100 and microRNA-21 as markers of survival and chemotherapy response in pancreatic ductal adenocarcinoma UICC stage II.
Breast Neoplasms
MicroRNA-20b promotes cell growth of breast cancer cells partly via targeting phosphatase and tensin homologue (PTEN).
Breast Neoplasms
MicroRNA?142?5p modulates breast cancer cell proliferation and apoptosis by targeting phosphatase and tensin homolog.
Breast Neoplasms
MiR-202-5p/PTEN mediates doxorubicin-resistance of breast cancer cells via PI3K/Akt signaling pathway.
Breast Neoplasms
miR-221/222 promote cancer stem-like cell properties and tumor growth of breast cancer via targeting PTEN and sustained Akt/NF-?B/COX-2 activation.
Breast Neoplasms
Molecular Mechanism of Secondary Endocrine Resistance in Luminal Breast Cancer.
Breast Neoplasms
MTDH mediates trastuzumab resistance in HER2 positive breast cancer by decreasing PTEN expression through an NF?B-dependent pathway.
Breast Neoplasms
mTOR inhibition in breast cancer: unraveling the complex mechanisms of mTOR signal transduction and its clinical implications in therapy.
Breast Neoplasms
Mutation analysis of PTEN/MMAC 1 in sporadic thyroid tumors.
Breast Neoplasms
Mutation analysis of the putative tumor suppression gene PTEN/MMAC1 in sporadic breast cancer.
Breast Neoplasms
Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in primary breast carcinomas.
Breast Neoplasms
Mutational analysis of the PTEN/MMAC1 gene in non-Hodgkin's lymphoma.
Breast Neoplasms
Non-Specific Blocking of miR-17-5p Guide Strand in Triple Negative Breast Cancer Cells by Amplifying Passenger Strand Activity.
Breast Neoplasms
Nuclear-cytoplasmic partitioning of phosphatase and tensin homologue deleted on chromosome 10 (PTEN) differentially regulates the cell cycle and apoptosis.
Breast Neoplasms
Over expression of PTEN induces apoptosis and prevents cell proliferation in breast cancer cells.
Breast Neoplasms
Overcoming endocrine resistance due to reduced PTEN levels in estrogen receptor-positive breast cancer by co-targeting mammalian target of rapamycin, protein kinase B, or mitogen-activated protein kinase kinase.
Breast Neoplasms
Overexpression of PIK3CA impacts global survival of patients with HER2 subtype breast carcinoma.
Breast Neoplasms
P-REX1 creates a positive feedback loop to activate growth factor receptor, PI3K/AKT and MEK/ERK signaling in breast cancer.
Breast Neoplasms
Pathogenic and likely pathogenic variants in PALB2, CHEK2, and other known breast cancer susceptibility genes among 1054 BRCA-negative Hispanics with breast cancer.
Breast Neoplasms
Phosphatase and tensin homologue deleted on chromosome 10 deficiency accelerates tumor induction in a mouse model of ErbB-2 mammary tumorigenesis.
Breast Neoplasms
Phosphatidylinositol 3-kinase regulatory subunit 1 and phosphatase and tensin homolog as therapeutic targets in breast cancer.
Breast Neoplasms
Phosphorylated galectin-3 mediates tumor necrosis factor-related apoptosis-inducing ligand signaling by regulating phosphatase and tensin homologue deleted on chromosome 10 in human breast carcinoma cells.
Breast Neoplasms
Physical Intimacy of Breast Cancer Cells with Mesenchymal Stem Cells Elicits Trastuzumab Resistance through Src Activation.
Breast Neoplasms
PI3K inhibition enhances the anti-tumor effect of eribulin in triple negative breast cancer.
Breast Neoplasms
PI3KCA mutations and/or PTEN loss in Her2-positive breast carcinomas treated with trastuzumab are not related to resistance to anti-Her2 therapy.
Breast Neoplasms
PIK3CA mutations, phosphatase and tensin homolog, human epidermal growth factor receptor 2 and insulin-like growth factor 1 receptor and adjuvant tamoxifen resistance in postmenopausal breast cancer patients.
Breast Neoplasms
PIK3CA mutations, PTEN, and pHER2 expression and impact on outcome in HER2-positive early-stage breast cancer patients treated with adjuvant chemotherapy and trastuzumab.
Breast Neoplasms
Point mutation and homozygous deletion of PTEN/MMAC1 in primary bladder cancers.
Breast Neoplasms
Potential prognostic value of heat-shock protein 90 in the presence of phosphatidylinositol-3-kinase overexpression or loss of PTEN, in invasive breast cancers.
Breast Neoplasms
Predictive factors of the tumor immunological microenvironment for long-term follow-up in early stage breast cancer.
Breast Neoplasms
PTEN and p53 cross-regulation induced by soy isoflavone genistein promotes mammary epithelial cell cycle arrest and lobuloalveolar differentiation.
Breast Neoplasms
PTEN Insufficiency Increases Breast Cancer Cell Metastasis In Vitro and In Vivo in a Xenograft Zebrafish Model.
Breast Neoplasms
PTEN insufficiency modulates ER+ breast cancer cell cycle progression and increases cell growth in vitro and in vivo.
Breast Neoplasms
PTEN, PIK3CA, p-AKT, and p-p70S6K status: association with trastuzumab response and survival in patients with HER2-positive metastatic breast cancer.
Breast Neoplasms
PTEN/MMAC1 in malignant melanoma and its importance for tumor progression.
Breast Neoplasms
PTP1B promotes aggressiveness of breast cancer cells by regulating PTEN but not EMT.
Breast Neoplasms
Role of tumor suppressor molecules in genomic perturbations and damaged DNA repair involved in the pathogenesis of cancer and neurodegeneration (Review).
Breast Neoplasms
Somatic mutation of the PTEN/MMAC1 gene in breast cancers with microsatellite instability.
Breast Neoplasms
Special bioactive compounds and functional foods may exhibit neuroprotective effects in patients with dementia (Review).
Breast Neoplasms
Suppression of PTEN function increases breast cancer chemotherapeutic drug resistance while conferring sensitivity to mTOR inhibitors.
Breast Neoplasms
The association between phosphatase and tensin homolog hypermethylation and patients with breast cancer, a meta-analysis and literature review.
Breast Neoplasms
The association of PTEN hypermethylation and breast cancer: a meta-analysis.
Breast Neoplasms
The phosphatidyl inositol 3-kinase signaling network: implications for human breast cancer.
Breast Neoplasms
The predictive role of phosphatase and tensin homolog (PTEN) loss, phosphoinositol-3 (PI3) kinase (PIK3CA) mutation, and PI3K pathway activation in sensitivity to trastuzumab in HER2-positive breast cancer: a meta-analysis.
Breast Neoplasms
The Prognostic Significance of Phosphatase and Tensin Homolog Loss in Breast Cancer.
Breast Neoplasms
The prognostic value and potential drug target of phosphatase and tensin homolog in breast cancer patients: A meta-analysis.
Breast Neoplasms
The prognostic value of phosphatase and tensin homolog negativity in breast cancer: A systematic review and meta-analysis of 32 studies with 4393 patients.
Breast Neoplasms
The role of the phosphatase and tensin homolog status in predicting pathological complete response to neoadjuvant anti-HER2 therapies in HER2-positive primary breast cancer: A meta-analysis.
Breast Neoplasms
Transforming growth factor-beta (TGF-beta)-inducible gene TMEPAI converts TGF-beta from a tumor suppressor to a tumor promoter in breast cancer.
Breast Neoplasms
[PI3K/AKT pathway activation and therapeutic consequences in breast cancer].
Breast Neoplasms
[PTEN/MMAC1 is apparently not a relevant tumor suppressor gene in development of hereditary breast carcinoma]
Burkitt Lymphoma
Role and mechanism of PTEN in Burkitt's lymphoma.
Carcinogenesis
A constitutively activated form of the p110beta isoform of PI3-kinase induces prostatic intraepithelial neoplasia in mice.
Carcinogenesis
A Novel Three-Dimensional Culture System of Polarized Epithelial Cells to Study Endometrial Carcinogenesis.
Carcinogenesis
A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis.
Carcinogenesis
Alteration of the PTEN/MMAC1 gene locus in primary lung cancer with distant metastasis.
Carcinogenesis
Alterations of PTEN/MMAC1, a candidate tumor suppressor gene, and its homologue, PTH2, in small cell lung cancer cell lines.
Carcinogenesis
Alterations of the PPP1R3 gene in human cancer.
Carcinogenesis
Androgen-induced programs for prostate epithelial growth and invasion arise in embryogenesis and are reactivated in cancer.
Carcinogenesis
Are aberrant transcripts of FHIT, TSG101, and PTEN/MMAC1 oncogenesis related?
Carcinogenesis
Assessment of biochemical recurrence of prostate cancer (Review).
Carcinogenesis
CircPSMC3 suppresses the proliferation and metastasis of gastric cancer by acting as a competitive endogenous RNA through sponging miR-296-5p.
Carcinogenesis
Clinical significance of tumor suppressor PTEN in colorectal carcinoma.
Carcinogenesis
Comparative analysis of SV40 17kT and LT function in vivo demonstrates that LT's C-terminus re-programs hepatic gene expression and is necessary for tumorigenesis in the liver.
Carcinogenesis
Comprehensive Analysis of PTEN in Primary Cutaneous Melanoma.
Carcinogenesis
Concomitant depletion of PTEN and p27 and overexpression of cyclin D1 may predict a worse prognosis for patients with post-operative stage II and III colorectal cancer.
Carcinogenesis
Conditional deletion of Pten causes bronchiolar hyperplasia.
Carcinogenesis
Detection of new PTEN/MMAC1 mutations in head and neck squamous cell carcinomas with loss of chromosome 10.
Carcinogenesis
Differential expression of tumor-associated genes and altered gut microbiome with decreased Akkermansia muciniphila confer a tumor-preventive microenvironment in intestinal epithelial Pten-deficient mice.
Carcinogenesis
Downregulation of miR?486?5p in papillary thyroid carcinoma tissue: A study based on microarray and miRNA sequencing.
Carcinogenesis
Effect of MicroRNA-766 Promotes Proliferation, Chemoresistance, Migration, and Invasion of Breast Cancer Cells.
Carcinogenesis
Epigenetic and genetic alterations of PTEN in hepatocellular carcinoma.
Carcinogenesis
Formaldehyde induces the apoptosis of BMCs of BALB/c mice via the PTEN/PI3K/Akt signal transduction pathway.
Carcinogenesis
Four MicroRNAs Promote Prostate Cell Proliferation with Regulation of PTEN and Its Downstream Signals In Vitro.
Carcinogenesis
Ganglioside GM3 modulates tumor suppressor PTEN-mediated cell cycle progression--transcriptional induction of p21(WAF1) and p27(kip1) by inhibition of PI-3K/AKT pathway.
Carcinogenesis
Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma.
Carcinogenesis
Genomic Predictors of Outcome in Prostate Cancer.
Carcinogenesis
Hair follicle defects and squamous cell carcinoma formation in Smad4 conditional knockout mouse skin.
Carcinogenesis
Hippo-mediated suppression of IRS2/AKT signaling prevents hepatic steatosis and liver cancer.
Carcinogenesis
Hunk negatively regulates c-myc to promote Akt-mediated cell survival and mammary tumorigenesis induced by loss of Pten.
Carcinogenesis
Increase in the nuclear localization of PTEN by the Toxoplasma GRA16 protein and subsequent induction of p53-dependent apoptosis and anticancer effect.
Carcinogenesis
Increased Activated Akt Expression in Renal Cell Carcinomas and Prognosis.
Carcinogenesis
Infrequent genetic alterations of the PTEN/MMAC1 gene in Japanese patients with primary cancers of the breast, lung, pancreas, kidney, and ovary.
Carcinogenesis
Infrequent genetic alterations of the tumor suppressor gene PTEN/MMAC1 in squamous cell carcinoma of the oral cavity.
Carcinogenesis
Infrequent mutations in the PTEN/MMAC1 gene among primary breast cancers.
Carcinogenesis
Integrin-linked kinase regulates phosphatase and tensin homologue activity to promote tumorigenesis in neuroblastoma cells.
Carcinogenesis
Klf5 deletion promotes Pten deletion-initiated luminal-type mouse prostate tumors through multiple oncogenic signaling pathways.
Carcinogenesis
Loss of ARID1A Promotes Hepatocellular Carcinoma Progression via Up-regulation of MYC Transcription.
Carcinogenesis
Loss of heterozygosity and immunoexpression of PTEN in oral epithelial dysplasia and squamous cell carcinoma.
Carcinogenesis
Loss of PTEN promotes tumor development in malignant melanoma.
Carcinogenesis
Low expression level of phosphatase and tensin homolog deleted on chromosome ten predicts poor prognosis in chronic lymphocytic leukemia.
Carcinogenesis
Metabolic Role of PTEN in Insulin Signaling and Resistance.
Carcinogenesis
MicroRNA-582 promotes tumorigenesis by targeting phosphatase and tensin homologue in colorectal cancer.
Carcinogenesis
MiR-200a acts as an oncogene in colorectal carcinoma by targeting PTEN.
Carcinogenesis
Mutation analysis of the PTEN/MMAC1 gene in cancers of the digestive tract.
Carcinogenesis
Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in advanced gastric carcinomas.
Carcinogenesis
Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in cervical cancer.
Carcinogenesis
Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in hepatocellular carcinoma.
Carcinogenesis
Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in primary breast carcinomas.
Carcinogenesis
Mutational analysis of the PTEN/MMAC1 gene in primary oesophageal squamous cell carcinomas.
Carcinogenesis
OncomiRs: the discovery and progress of microRNAs in cancers.
Carcinogenesis
Overexpression of the tumor suppressor gene phosphatase and tensin homologue partially inhibits wnt-1-induced mammary tumorigenesis.
Carcinogenesis
Phosphatase and tensin homologue deleted on chromosome 10 deficiency accelerates tumor induction in a mouse model of ErbB-2 mammary tumorigenesis.
Carcinogenesis
Phosphorylation of phosphatase and tensin homolog induced by
Carcinogenesis
Point mutation and homozygous deletion of PTEN/MMAC1 in primary bladder cancers.
Carcinogenesis
Predicting high risk disease using serum and DNA biomarkers.
Carcinogenesis
Proteomic and transcriptomic profiling of Pten gene-knockout mouse model of prostate cancer.
Carcinogenesis
PTEN and myotubularin: novel phosphoinositide phosphatases.
Carcinogenesis
PTEN Inhibits Inflammatory Bone Loss in Ligature-Induced Periodontitis via IL1 and TNF-?.
Carcinogenesis
PTEN protects kidney against acute kidney injury by alleviating apoptosis and promoting autophagy via regulating HIF1-? and mTOR through PI3K/Akt pathway.
Carcinogenesis
PTEN regulates apoptotic cell death through PI3-K/Akt/GSK3? signaling pathway in DMH induced early colon carcinogenesis in rat.
Carcinogenesis
PTEN/MMAC1 expression in esophageal squamous cell carcinomas.
Carcinogenesis
PTEN/MMAC1 gene mutation is a rare event in soft tissue sarcomas without specific balanced translocations.
Carcinogenesis
PTEN/MMAC1/TEP1 in signal transduction and tumorigenesis.
Carcinogenesis
PTEN: A crucial mediator of mitochondria-dependent apoptosis.
Carcinogenesis
Radiation-associated small cell neuroendocrine carcinoma of the thyroid: a case report with molecular analyses.
Carcinogenesis
ROS enhances CXCR4-mediated functions through inactivation of PTEN in prostate cancer cells.
Carcinogenesis
Shank-interacting protein-like 1 promotes tumorigenesis via PTEN inhibition in human tumor cells.
Carcinogenesis
Somatic mutations of the PTEN/MMAC1 gene in fifteen Japanese endometrial cancers: evidence for inactivation of both alleles.
Carcinogenesis
Somatic mutations of the PTEN/NMAC1 gene associated with frequent chromosomal loss detected using comparative genomic hybridization in endometrial cancer.
Carcinogenesis
Sprouty1 induces a senescence-associated secretory phenotype by regulating NF?B activity: implications for tumorigenesis.
Carcinogenesis
Stanozolol administration combined with exercise leads to decreased telomerase activity possibly associated with liver aging.
Carcinogenesis
Targeting Nicotinamide N-Methyltransferase and miR-449a in EGFR-TKI-Resistant Non-Small-Cell Lung Cancer Cells.
Carcinogenesis
The antidepressant sertraline inhibits translation initiation by curtailing mammalian target of rapamycin signaling.
Carcinogenesis
The Antioxidant from Ethanolic Extract of Rosa cymosa Fruits Activates Phosphatase and Tensin Homolog In Vitro and In Vivo: A New Insight on Its Antileukemic Effect.
Carcinogenesis
The deubiquitinase USP10 restores PTEN activity and inhibits non-small cell lung cancer cell proliferation.
Carcinogenesis
Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model.
Carcinogenesis
Wnt/?-catenin activation and macrophage induction during liver cancer development following steatosis.
Carcinogenesis
[Activation and prognostic significance of AKT, NF-kappaB and STAT3 in breast cancer with lymph node metastasis and estrogen receptor expression]
Carcinogenesis
[Expression of PTEN-encoding product in different stages of carcinogenesis and progression of gastric carcinoma]
Carcinogenesis
[Mutation and expression of tumor suppressor gene phosphatase and tensin homolog deleted in chromosome 10 in oral squamous cell carcinoma.]
Carcinoma
A clinical study on the expression of PTEN in renal cell carcinoma in children.
Carcinoma
A Late G1 Lipid Checkpoint That Is Dysregulated in Clear Cell Renal Carcinoma Cells.
Carcinoma
Abnormal structure and expression of PTEN/MMAC1 gene in human uterine cancers.
Carcinoma
Activation of peroxisome proliferator-activated receptor beta/delta induces lung cancer growth via peroxisome proliferator-activated receptor coactivator gamma-1alpha.
Carcinoma
Activation of PI3K is associated with reduced survival in renal cell carcinoma.
Carcinoma
Allelic loss at 10q23.3 but lack of mutation of PTEN/MMAC1 in chromophobe renal cell carcinoma.
Carcinoma
Altered expression of miR-21 and PTEN in human laryngeal and hypopharyngeal squamous cell carcinomas.
Carcinoma
An Immunohistochemical Study of the PTEN/AKT Pathway Involvement in Canine and Feline Mammary Tumors.
Carcinoma
Association of genetic polymorphisms in PTEN and additional gene-gene interaction with risk of esophageal squamous cell carcinoma in Chinese Han population.
Carcinoma
c-Myc phosphorylation by PKC? represses prostate tumorigenesis.
Carcinoma
Chemoresistance is associated with Beclin-1 and PTEN expression in epithelial ovarian cancers.
Carcinoma
Chromosome 20q13.2 ZNF217 locus amplification correlates with decreased E-cadherin expression in ovarian clear cell carcinoma with PI3K-Akt pathway alterations.
Carcinoma
Circulating microRNA-21 (MIR-21) and phosphatase and tensin homolog (PTEN) are promising novel biomarkers for detection of oral squamous cell carcinoma.
Carcinoma
Cordycepin induces apoptotic cell death and inhibits cell migration in renal cell carcinoma via regulation of microRNA-21 and PTEN phosphatase.
Carcinoma
Correlation between PTEN gene polymorphism and oral squamous cell carcinoma.
Carcinoma
Correspondence re: W.M. Lin et al., loss of heterozygosity and mutational analysis of the PTEN/MMAC1 gene in synchronous endometrial and ovarian carcinomas. Clin. Cancer Res., 4: 2577-2583, 1998.
Carcinoma
Detection of new PTEN/MMAC1 mutations in head and neck squamous cell carcinomas with loss of chromosome 10.
Carcinoma
Distinct regions of allelic imbalance on chromosome 10q22-q26 in squamous cell carcinomas of the lung.
Carcinoma
Dysregulated Expression of Phosphorylated Epidermal Growth Factor Receptor and Phosphatase and Tensin Homologue in Canine Cutaneous Papillomas and Squamous Cell Carcinomas.
Carcinoma
Effect of PTEN Antisense Oligonucleotide on Oesophageal Squamous Cell Carcinoma Cell Lines.
Carcinoma
Expression of PTEN and KAI1 tumor suppressor genes in pancreatic carcinoma and its association with different pathological factors.
Carcinoma
Fentanyl inhibits the progression of human gastric carcinoma MGC-803 cells by modulating NF-?B-dependent gene expression in vivo.
Carcinoma
Genetic alterations of the tumor suppressor gene PTEN/MMAC1 in human brain metastases.
Carcinoma
Genotypic analysis of tumor suppressor genes PTEN/MMAC1 and p53 in head and neck squamous cell carcinomas.
Carcinoma
Herpes simplex virus type 1 VP22-mediated intercellular delivery of PTEN increases the antitumor activity of PTEN in esophageal squamous cell carcinoma cells in vitro and in vivo.
Carcinoma
High levels of phosphatase and tensin homolog expression are associated with tumor progression, tumor recurrence, and systemic metastases in pT1 urothelial carcinoma of the bladder: a tissue microarray study of 156 patients treated by transurethral resection.
Carcinoma
Histologic-Type Specific Role of Cell Cycle Regulators in Non-Small Cell Lung Carcinoma.
Carcinoma
Histone demethylase JMJD2A drives prostate tumorigenesis through transcription factor ETV1.
Carcinoma
Immunohistochemical expression of phosphatase and tensin homolog in histologic gradings of oral squamous cell carcinoma.
Carcinoma
Infrequent genetic alterations of the tumor suppressor gene PTEN/MMAC1 in squamous cell carcinoma of the oral cavity.
Carcinoma
Intragenic PTEN/MMAC1 loss of heterozygosity in conventional (clear-cell) renal cell carcinoma is associated with poor patient prognosis.
Carcinoma
Is NEDD4-1 a negative regulator of phosphatase and tensin homolog in gastric carcinogenesis?
Carcinoma
Lack of deletions of the PTEN/MMAC1 and MXI1 loci in renal cell carcinoma by interphase cytogenetics.
Carcinoma
Longitudinal Cell-Free DNA Analysis in Patients with Small Cell Lung Cancer Reveals Dynamic Insights into Treatment Efficacy and Disease Relapse.
Carcinoma
Loss of ARID1A expression and its relationship with PI3K-Akt pathway alterations and ZNF217 amplification in ovarian clear cell carcinoma.
Carcinoma
Loss of heterozygosity and mutational analysis of the PTEN/MMAC1 gene in synchronous endometrial and ovarian carcinomas.
Carcinoma
Loss of PTEN Expression Is Associated With High MicroRNA 24 Level and Poor Prognosis in Patients With Tongue Squamous Cell Carcinoma.
Carcinoma
Loss of PTEN is associated with elevated EGFR and HER2 expression and worse prognosis in salivary gland cancer.
Carcinoma
Low expression of phosphatase and tensin homolog in clear?cell renal cell carcinoma contributes to chemoresistance through activating the Akt/HDM2 signaling pathway.
Carcinoma
MiR-132 promotes the proliferation, invasion and migration of human pancreatic carcinoma by inhibition of the tumor suppressor gene PTEN.
Carcinoma
miR-222 promotes invasion and migration of ovarian carcinoma by targeting PTEN.
Carcinoma
MiR-624-3p Promotes Esophageal Squamous Cell Carcinoma Progression via Targeting Phosphatase and Tensin Homologue.
Carcinoma
Molecular carcinogenesis in equine penile cancer: A potential animal model for human penile cancer.
Carcinoma
Molecular genetic defects in endometriosis.
Carcinoma
Molecular mechanism of microRNA-26a regulation of phosphatase and tensin homolog gene in condyloma acuminatum and penile squamous cell carcinoma.
Carcinoma
Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in advanced gastric carcinomas.
Carcinoma
Mutational analysis of the PTEN/MMAC1 gene in primary oesophageal squamous cell carcinomas.
Carcinoma
Overexpression of PTEN suppresses non-small-cell lung carcinoma metastasis through inhibition of integrin ?V?6 signaling.
Carcinoma
Phosphatase and tensin homolog (PTEN) expression on oncologic outcome in renal cell carcinoma: A systematic review and meta-analysis.
Carcinoma
Phosphatase and tensin homolog deleted on chromosome 10 degradation induced by NEDD4 promotes acquired erlotinib resistance in non-small-cell lung cancer.
Carcinoma
Phosphatase and tensin homolog overexpression decreases proliferation and invasion and increases apoptosis in oral squamous cell carcinoma cells.
Carcinoma
Phosphorylated mammalian target of rapamycin is associated with an adverse outcome in oral squamous cell carcinoma.
Carcinoma
Point mutation and homozygous deletion of PTEN/MMAC1 in primary bladder cancers.
Carcinoma
Poly(ADP-ribose) polymerase 1 modulates the lethality of CHK1 inhibitors in mammary tumors.
Carcinoma
Poor prognostic clinicopathologic features correlate with VEGF expression but not with PTEN expression in squamous cell carcinoma of the larynx.
Carcinoma
Prognostic role of PPAR-? and PTEN in the renal cell carcinoma.
Carcinoma
Protein expression and prognostic value of genes in the erb-b signaling pathway in advanced ovarian carcinomas.
Carcinoma
PTEN and ?-SMA Expression and Diagnostic Role in Oral Submucous Fibrosis and Oral Squamous Cell Carcinoma with Concomitant Oral Submucous Fibrosis.
Carcinoma
PTEN deficiency is fully penetrant for prostate adenocarcinoma in C57BL/6 mice via mTOR-dependent growth.
Carcinoma
PTEN expression in patients with carcinoma of the cervix and its association with p53, Ki-67 and CD31.
Carcinoma
PTEN gene is infrequently hypermethylated in human esophageal squamous cell carcinoma.
Carcinoma
PTEN Is Associated With Worse Local Control in Early Stage Supraglottic Laryngeal Cancer Treated With Radiotherapy.
Carcinoma
PTEN/MMAC1 expression in esophageal squamous cell carcinomas.
Carcinoma
PTEN/MMAC1 is infrequently mutated in pT2 and pT3 carcinomas of the prostate.
Carcinoma
Relationship between expression of P27, Fragile Histidine Triad (FHT), phosphatase and tensin homolog deleted on chromosome ten (PTEN), P73, and prognosis in esophageal squamous cell carcinoma.
Carcinoma
Role of microRNA-21 and effect on PTEN in Kazakh's esophageal squamous cell carcinoma.
Carcinoma
Rosiglitazone suppresses human lung carcinoma cell growth through PPAR{gamma}-dependent and PPAR{gamma}-independent signal pathways.
Carcinoma
Simultaneous inactivation of Par-4 and PTEN in vivo leads to synergistic NF-kappaB activation and invasive prostate carcinoma.
Carcinoma
Small Molecules Alter VEGFR and PTEN Expression in HPV-positive and -negative SCC: New Hope for Targeted-therapy.
Carcinoma
Somatic mutation and homozygous deletion of PTEN/MMAC1 gene of 10q23 in renal cell carcinoma.
Carcinoma
Somatic mutations of the PTEN/NMAC1 gene associated with frequent chromosomal loss detected using comparative genomic hybridization in endometrial cancer.
Carcinoma
Study of the Association of Phosphatase and Tensin Homolog and p27 Expressions in Endometrial Hyperplasia and Carcinoma.
Carcinoma
The crosstalk between p38 and Akt signaling pathways orchestrates EMT by regulating SATB2 expression in NSCLC cells.
Carcinoma
The Expression and Prognostic Impact of the PI3K/AKT/mTOR Signaling Pathway in Advanced Esophageal Squamous Cell Carcinoma.
Carcinoma
Upregulation of PTEN suppresses invasion in Tca8113 tongue cancer cells through repression of epithelial-mesenchymal transition (EMT).
Carcinoma
Wild-type phosphatase and tensin homolog deleted on chromosome 10 improved the sensitivity of cells to rapamycin through regulating phosphorylation of Akt in esophageal squamous cell carcinoma.
Carcinoma
[Correlation analysis of VEGF and PTEN expression in gingival carcinoma].
Carcinoma
[Expression of PTEN-encoding product in different stages of carcinogenesis and progression of gastric carcinoma]
Carcinoma
[Expression of two kinds of tumor correlation protein in laryngeal carcinoma and precancerous lesions]
Carcinoma
[Mutation and expression of tumor suppressor gene phosphatase and tensin homolog deleted in chromosome 10 in oral squamous cell carcinoma.]
Carcinoma, Adenosquamous
Expression of phosphatase and tensin homolog and programmed cell death ligand 1 in adenosquamous carcinoma of the lung.
Carcinoma, Ductal
Frequent genetic alterations in EGFR- and HER2-driven pathways in breast cancer brain metastases.
Carcinoma, Ductal
[Expression of microRNA-21 in invasive ductal carcinoma of the breast and its association with phosphatase and tensin homolog deleted from chromosome expression and clinicopathologic features]
Carcinoma, Embryonal
Loss of the tumor suppressor gene PTEN marks the transition from intratubular germ cell neoplasias (ITGCN) to invasive germ cell tumors.
Carcinoma, Endometrioid
Down-regulation of miR-145 and miR-143 might be associated with DNA methyltransferase 3B overexpression and worse prognosis in endometrioid carcinomas.
Carcinoma, Endometrioid
Endometrial tumorigenesis in Pten(+/-) mice is independent of coexistence of estrogen and estrogen receptor ?.
Carcinoma, Endometrioid
Genetic analysis and phosphoinositide 3-kinase/protein kinase B signaling pathway status in ovarian endometrioid borderline tumor samples.
Carcinoma, Hepatocellular
Coexpression of SALL4 with HDAC1 and/or HDAC2 is associated with underexpression of PTEN and poor prognosis in patients with hepatocellular carcinoma.
Carcinoma, Hepatocellular
Combined Phosphatase and Tensin Homolog (PTEN) Loss and Fatty Acid Synthase (FAS) Overexpression Worsens the Prognosis of Chinese Patients with Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Correlation between loss of PTEN expression and PKB/AKT phosphorylation in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Down-regulated lncRNA TP73-AS1 reduces radioresistance in hepatocellular carcinoma via the PTEN/Akt signaling pathway.
Carcinoma, Hepatocellular
Down-regulation of PTEN expression due to loss of promoter activity in human hepatocellular carcinoma cell lines.
Carcinoma, Hepatocellular
Downregulation of STRAP promotes tumor growth and metastasis in hepatocellular carcinoma via reducing PTEN level.
Carcinoma, Hepatocellular
Epigenetic and genetic alterations of PTEN in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Expression and significance of PTEN and miR-92 in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Expression of phosphatase and tensin homolog deleted on chromosome ten in liver of athymic mice with hepatocellular carcinoma and the effect of Fuzheng Jiedu Decoction.
Carcinoma, Hepatocellular
Genetic alterations and expression of PTEN and its relationship with cancer stem cell markers to investigate pathogenesis and to evaluate prognosis in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Hepatitis B Virus Induces Cell Proliferation via HBx-Induced microRNA-21 in Hepatocellular Carcinoma by Targeting Programmed Cell Death Protein4 (PDCD4) and Phosphatase and Tensin Homologue (PTEN).
Carcinoma, Hepatocellular
Hepatitis C virus NS5A drives a PTEN-PI3K/Akt feedback loop to support cell survival.
Carcinoma, Hepatocellular
Increase in the nuclear localization of PTEN by the Toxoplasma GRA16 protein and subsequent induction of p53-dependent apoptosis and anticancer effect.
Carcinoma, Hepatocellular
Indole-3-carbinol inhibits tumorigenicity of hepatocellular carcinoma cells via suppression of microRNA-21 and upregulation of phosphatase and tensin homolog.
Carcinoma, Hepatocellular
Inhibition of IRS-1 by hepatitis C virus infection leads to insulin resistance in a PTEN-dependent manner.
Carcinoma, Hepatocellular
Jianpijiedu fang improves survival of hepatocarcinoma mice by affecting phosphatase and tensin homolog, phosphoinositide 3-kinase, and focal adhesion kinase.
Carcinoma, Hepatocellular
Ligands of the peroxisome proliferator-activated receptor ? inhibit hepatoce llular carcinoma cell proliferation.
Carcinoma, Hepatocellular
Long non?coding RNA Fer?1?like family member 4 suppresses hepatocellular carcinoma cell proliferation by regulating PTEN in vitro and in vivo.
Carcinoma, Hepatocellular
Loss of heterozygosity on chromosome 10q23 and mutation of the phosphatase and tensin homolog deleted from chromosome 10 tumor suppressor gene in Korean hepatocellular carcinoma patients.
Carcinoma, Hepatocellular
Loss of phosphatase and tensin homolog enhances cell invasion and migration through AKT/Sp-1 transcription factor/matrix metalloproteinase 2 activation in hepatocellular carcinoma and has clinicopathologic significance.
Carcinoma, Hepatocellular
Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in hepatocellular carcinoma.
Carcinoma, Hepatocellular
NEDD4 promotes cell growth and migration via PTEN/PI3K/AKT signaling in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Non-alcoholic steatohepatitis and hepatocellular carcinoma: lessons from hepatocyte-specific phosphatase and tensin homolog (PTEN)-deficient mice.
Carcinoma, Hepatocellular
ONTD induces growth arrest and apoptosis of human hepatoma Bel-7402 cells though a peroxisome proliferator-activated receptor ?-dependent pathway.
Carcinoma, Hepatocellular
Phosphatase and tensin homologue genetic polymorphisms and their interactions with viral mutations on the risk of hepatocellular carcinoma.
Carcinoma, Hepatocellular
PTEN and hTERT gene expression and the correlation with human hepatocellular carcinoma.
Carcinoma, Hepatocellular
PTEN/MMAC1 mutations in hepatocellular carcinomas.
Carcinoma, Hepatocellular
PTEN/MMAC1 mutations in hepatocellular carcinomas: somatic inactivation of both alleles in tumors.
Carcinoma, Hepatocellular
Pterostilbene increases PTEN expression through the targeted downregulation of microRNA-19a in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Radiation-inducible PTEN expression radiosensitises hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
Sequencing the full-length of the phosphatase and tensin homolog (PTEN) gene in hepatocellular carcinoma (HCC) using the 454 GS20 and Illumina GA DNA sequencing platforms.
Carcinoma, Hepatocellular
The ménage à trois of autophagy, lipid droplets and liver disease.
Carcinoma, Hepatocellular
Up-Regulation of Phosphatase in Regenerating Liver-3 (PRL-3) Contributes to Malignant Progression of Hepatocellular Carcinoma by Activating Phosphatase and Tensin Homolog Deleted on Chromosome Ten (PTEN)/Phosphoinositide 3-Kinase (PI3K)/AKT Signaling Pathway.
Carcinoma, Hepatocellular
Upregulation of PTEN involved in rosiglitazone-induced apoptosis in human hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
[Expressions of phosphorylated-Smad2 and PTEN in hepatocellular carcinomas and adjacent liver tissues]
Carcinoma, Hepatocellular
[Relationship between the expression of PTEN protein and phosphorylation of MAPK in hepatocellular carcinomas and their surrounding liver tissues]
Carcinoma, Intraductal, Noninfiltrating
Frequent genetic alterations in EGFR- and HER2-driven pathways in breast cancer brain metastases.
Carcinoma, Non-Small-Cell Lung
Activation of peroxisome proliferator-activated receptor beta/delta induces lung cancer growth via peroxisome proliferator-activated receptor coactivator gamma-1alpha.
Carcinoma, Non-Small-Cell Lung
Circular RNA circ-PTEN elevates PTEN inhibiting the proliferation of non-small cell lung cancer cells.
Carcinoma, Non-Small-Cell Lung
Circular RNA circ_0001287 inhibits the proliferation, metastasis, and radiosensitivity of non-small cell lung cancer cells by sponging microRNA miR-21 and up-regulating phosphatase and tensin homolog expression.
Carcinoma, Non-Small-Cell Lung
High levels of phosphatase and tensin homolog expression predict favorable prognosis in patients with non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
High levels of Phosphatase and Tensin Homolog Expression Predict Favorable Prognosis in Patients with Non-small Cell Lung Cancer.
Carcinoma, Non-Small-Cell Lung
Increased tissue factor expression is associated with reduced survival in non-small cell lung cancer and with mutations of TP53 and PTEN.
Carcinoma, Non-Small-Cell Lung
Loss of phosphatase and tensin homolog expression correlates with clinicopathological features of non-small cell lung cancer patients and its impact on survival: A systematic review and meta-analysis.
Carcinoma, Non-Small-Cell Lung
miR-543 is up-regulated in gefitinib-resistant non-small cell lung cancer and promotes cell proliferation and invasion via phosphatase and tensin homolog.
Carcinoma, Non-Small-Cell Lung
Overexpression of PTEN suppresses non-small-cell lung carcinoma metastasis through inhibition of integrin ?V?6 signaling.
Carcinoma, Non-Small-Cell Lung
Phosphatase and tensin homolog protein may be linked to lymph node metastasis and tumor node metastasis staging in nonsmall cell lung cancer.
Carcinoma, Non-Small-Cell Lung
PTEN expression is a prognostic marker for patients with non-small cell lung cancer: a systematic review and meta-analysis of the literature.
Carcinoma, Non-Small-Cell Lung
Pten inactivation accelerates oncogenic K-ras-initiated tumorigenesis in a mouse model of lung cancer.
Carcinoma, Non-Small-Cell Lung
PTEN/MMAC1 mutations identified in small cell, but not in non-small cell lung cancers.
Carcinoma, Non-Small-Cell Lung
Rosiglitazone suppresses human lung carcinoma cell growth through PPAR{gamma}-dependent and PPAR{gamma}-independent signal pathways.
Carcinoma, Non-Small-Cell Lung
Suberoylanilide hydroxamic acid overcomes erlotinib-acquired resistance via phosphatase and tensin homolog deleted on chromosome 10-mediated apoptosis in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
The crosstalk between p38 and Akt signaling pathways orchestrates EMT by regulating SATB2 expression in NSCLC cells.
Carcinoma, Non-Small-Cell Lung
The deubiquitinase USP10 restores PTEN activity and inhibits non-small cell lung cancer cell proliferation.
Carcinoma, Non-Small-Cell Lung
The influence of circular RNAs on autophagy and disease progression.
Carcinoma, Non-Small-Cell Lung
[Expression of Gemcitabine-resistance-related gene and polymorphism of ribonucleotide reductase M1 gene promoter in Gemcitabine-resistant A549/Gem and NCI-H460/Gem cell lines]
Carcinoma, Renal Cell
A clinical study on the expression of PTEN in renal cell carcinoma in children.
Carcinoma, Renal Cell
A Late G1 Lipid Checkpoint That Is Dysregulated in Clear Cell Renal Carcinoma Cells.
Carcinoma, Renal Cell
Activation of PI3K is associated with reduced survival in renal cell carcinoma.
Carcinoma, Renal Cell
Allelic loss at 10q23.3 but lack of mutation of PTEN/MMAC1 in chromophobe renal cell carcinoma.
Carcinoma, Renal Cell
Cordycepin induces apoptotic cell death and inhibits cell migration in renal cell carcinoma via regulation of microRNA-21 and PTEN phosphatase.
Carcinoma, Renal Cell
Intragenic PTEN/MMAC1 loss of heterozygosity in conventional (clear-cell) renal cell carcinoma is associated with poor patient prognosis.
Carcinoma, Renal Cell
Lack of deletions of the PTEN/MMAC1 and MXI1 loci in renal cell carcinoma by interphase cytogenetics.
Carcinoma, Renal Cell
Low expression of phosphatase and tensin homolog in clear?cell renal cell carcinoma contributes to chemoresistance through activating the Akt/HDM2 signaling pathway.
Carcinoma, Renal Cell
Phosphatase and tensin homolog (PTEN) expression on oncologic outcome in renal cell carcinoma: A systematic review and meta-analysis.
Carcinoma, Renal Cell
Point mutation and homozygous deletion of PTEN/MMAC1 in primary bladder cancers.
Carcinoma, Renal Cell
Prognostic role of PPAR-? and PTEN in the renal cell carcinoma.
Carcinoma, Renal Cell
Somatic mutation and homozygous deletion of PTEN/MMAC1 gene of 10q23 in renal cell carcinoma.
Carcinoma, Squamous Cell
Altered expression of miR-21 and PTEN in human laryngeal and hypopharyngeal squamous cell carcinomas.
Carcinoma, Squamous Cell
Detection of new PTEN/MMAC1 mutations in head and neck squamous cell carcinomas with loss of chromosome 10.
Carcinoma, Squamous Cell
Dysregulated Expression of Phosphorylated Epidermal Growth Factor Receptor and Phosphatase and Tensin Homologue in Canine Cutaneous Papillomas and Squamous Cell Carcinomas.
Carcinoma, Squamous Cell
Genotypic analysis of tumor suppressor genes PTEN/MMAC1 and p53 in head and neck squamous cell carcinomas.
Carcinoma, Squamous Cell
Histologic-Type Specific Role of Cell Cycle Regulators in Non-Small Cell Lung Carcinoma.
Carcinoma, Squamous Cell
Infrequent genetic alterations of the tumor suppressor gene PTEN/MMAC1 in squamous cell carcinoma of the oral cavity.
Carcinoma, Squamous Cell
Loss of PTEN Expression Is Associated With High MicroRNA 24 Level and Poor Prognosis in Patients With Tongue Squamous Cell Carcinoma.
Carcinoma, Squamous Cell
Molecular carcinogenesis in equine penile cancer: A potential animal model for human penile cancer.
Carcinoma, Squamous Cell
Molecular mechanism of microRNA-26a regulation of phosphatase and tensin homolog gene in condyloma acuminatum and penile squamous cell carcinoma.
Carcinoma, Squamous Cell
Mutational analysis of the PTEN/MMAC1 gene in primary oesophageal squamous cell carcinomas.
Carcinoma, Squamous Cell
Poor prognostic clinicopathologic features correlate with VEGF expression but not with PTEN expression in squamous cell carcinoma of the larynx.
Carcinoma, Squamous Cell
PTEN expression in patients with carcinoma of the cervix and its association with p53, Ki-67 and CD31.
Carcinoma, Squamous Cell
PTEN/MMAC1 expression in esophageal squamous cell carcinomas.
Carcinoma, Squamous Cell
Small Molecules Alter VEGFR and PTEN Expression in HPV-positive and -negative SCC: New Hope for Targeted-therapy.
Carcinoma, Squamous Cell
Upregulation of PTEN suppresses invasion in Tca8113 tongue cancer cells through repression of epithelial-mesenchymal transition (EMT).
Carcinoma, Verrucous
Differential expression of microRNAs miR-21, miR-31, miR-203, miR-125a-5p and miR-125b and proteins PTEN and p63 in verrucous carcinoma of the head and neck.
Cardiomegaly
Atorvastatin inhibits GSK-3beta phosphorylation by cardiac hypertrophic stimuli.
Cardiomegaly
Panhistone deacetylase inhibitors inhibit proinflammatory signaling pathways to ameliorate interleukin-18-induced cardiac hypertrophy.
Cardiomegaly
[MicroRNA-23a knockdown attenuates angiotensin ? induced hypertrophy in rat H9c2 cells via activating PTEN and AMPK pathway].
Cardiomyopathies
PTEN Inhibitor VO-OHpic Attenuates Inflammatory M1 Macrophages and Cardiac Remodeling in Doxorubicin-Induced Cardiomyopathy.
Cardiovascular Diseases
Effect of Phosphatase and Tensin Homologue on Chromosome 10 on Angiotensin II-Mediated Proliferation, Collagen Synthesis, and Akt/P27 Signaling in Neonatal Rat Cardiac Fibroblasts.
Cardiovascular Diseases
The expression of microRNAs and exposure to environmental contaminants related to human health: a review.
Cataract
AKT activation promotes PTEN hamartoma tumor syndrome-associated cataract development.
Cerebellar Neoplasms
A heterozygous frameshift mutation of the PTEN/MMAC1 gene in a patient with Lhermitte-Duclos disease - only the mutated allele was expressed in the cerebellar tumor.
Cerebral Hemorrhage
Effect of miR-130a on neuronal injury in rats with intracranial hemorrhage through PTEN/PI3K/AKT signaling pathway.
Cerebral Hemorrhage
MicroRNA-26b/PTEN Signaling Pathway Mediates Glycine-Induced Neuroprotection in SAH Injury.
Cerebral Infarction
Association of PTEN genetic polymorphisms with atherosclerotic cerebral infarction in the Han Chinese population.
Cerebral Infarction
miR-130a alleviates neuronal apoptosis and changes in expression of Bcl-2/Bax and caspase-3 in cerebral infarction rats through PTEN/PI3K/Akt signaling pathway.
Cholangiocarcinoma
miR-17-92 cluster promotes cholangiocarcinoma growth: evidence for PTEN as downstream target and IL-6/Stat3 as upstream activator.
Cholangiocarcinoma
Sodium iodide symporter and phosphatase and tensin homolog deleted on chromosome ten expression in cholangiocarcinoma analysis with clinicopathological parameters.
Cholangiocarcinoma
The expression of phospho-AKT1 and phospho-MTOR is associated with a favorable prognosis independent of PTEN expression in intrahepatic cholangiocarcinomas.
Cholera
miR-132-3p boosts caveolae-mediated transcellular transport in glioma endothelial cells by targeting PTEN/PI3K/PKB/Src/Cav-1 signaling pathway.
Chordoma
Expression of PTEN and mTOR in sacral chordoma and association with poor prognosis.
Colitis
Antioxidant properties of mesalamine in colitis inhibit phosphoinositide 3-kinase signaling in progenitor cells.
Colitis
Colonic Inhibition of Phosphatase and Tensin Homolog Increases Colitogenic Bacteria, Causing Development of Colitis in Il10-/- Mice.
Colitis
Disruption of Pten speeds onset and increases severity of spontaneous colitis in Il10(-/-) mice.
Colitis
Fortunellin-Induced Modulation of Phosphatase and Tensin Homolog by MicroRNA-374a Decreases Inflammation and Maintains Intestinal Barrier Function in Colitis.
Colonic Neoplasms
Chemoresistant KM12C colon cancer cells are addicted to low cyclic AMP levels in a phosphodiesterase 4-regulated compartment via effects on phosphoinositide 3-kinase.
Colonic Neoplasms
Downregulation of AIF by HIF-1 contributes to hypoxia-induced epithelial-mesenchymal transition of colon cancer.
Colonic Neoplasms
Fibroblast-derived CXCL12 regulates PTEN expression and is associated with the proliferation and invasion of colon cancer cells via PI3k/Akt signaling.
Colonic Neoplasms
Inhibition of the phosphatidylinositol 3-kinase pathway contributes to HT29 and Caco-2 intestinal cell differentiation.
Colonic Neoplasms
miRNA-29a inhibits colon cancer growth by regulation of the PTEN/Akt/GSK3? and Wnt/?-catenin signaling pathways.
Colonic Neoplasms
No association between phosphatase and tensin homolog genetic polymorphisms and colon cancer.
Colonic Neoplasms
Phosphatase and Tensin Homolog (PTEN) Represses Colon Cancer Progression through Inhibiting Paxillin Transcription via PI3K/AKT/NF-?B Pathway.
Colonic Neoplasms
Phosphatase and tensin homologue deleted on chromosome 10.
Colonic Neoplasms
Potential targets for prevention of colorectal cancer: a focus on PI3K/Akt/mTOR and Wnt pathways.
Colonic Neoplasms
PTEN loss induces epithelial--mesenchymal transition in human colon cancer cells.
Colorectal Neoplasms
"Squirrel" Primer-Based PCR Assay for Direct and Targeted Sanger Sequencing of Short Genomic Segments.
Colorectal Neoplasms
A comprehensive analysis of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) loss in colorectal cancer.
Colorectal Neoplasms
A synthetically lethal nanomedicine delivering novel inhibitors of polynucleotide kinase 3'-phosphatase (PNKP) for targeted therapy of PTEN-deficient colorectal cancer.
Colorectal Neoplasms
Analysis of promoter methylation and epigenetic regulation of miR-32 in colorectal cancer cells.
Colorectal Neoplasms
Assessment of PI3K/AKT/PTEN signaling pathway activity in colorectal cancer using quantum dot-conjugated antibodies.
Colorectal Neoplasms
Association of genetic polymorphisms in PTEN and additional interaction with alcohol consumption and smoking on colorectal cancer in Chinese population.
Colorectal Neoplasms
Can we accurately report PTEN status in advanced colorectal cancer?
Colorectal Neoplasms
Colorectal carcinomas and PTEN/MMAC1 gene mutations.
Colorectal Neoplasms
Combined Analysis of EGFR and PTEN Status in Patients With KRAS Wild-Type Metastatic Colorectal Cancer.
Colorectal Neoplasms
Correlation of over-expressions of miR-21 and Notch-1 in human colorectal cancer with clinical stages.
Colorectal Neoplasms
Curcumin cytotoxicity is enhanced by PTEN disruption in colorectal cancer cells.
Colorectal Neoplasms
Evaluating the value of Amphiregulin, Phosphatase and Tensin Homologue (PTEN) and P21 Expression for Anti-EGFR Treatment in Metastatic Colorectal Carcinoma.
Colorectal Neoplasms
FOLFIRI and Cetuximab Every Second Week for First-Line Treatment of KRAS Wild-Type Metastatic Colorectal Cancer According to Phosphatase and Tensin Homolog Expression: A Phase II Study.
Colorectal Neoplasms
Gambogic acid regulates the migration and invasion of colorectal cancer via microRNA-21-mediated activation of phosphatase and tensin homolog.
Colorectal Neoplasms
Genome-wide search for loss of heterozygosity in Chinese patients with sporadic colorectal cancer.
Colorectal Neoplasms
In depth evaluation of the prognostic and predictive utility of PTEN immunohistochemistry in colorectal carcinomas: performance of three antibodies with emphasis on intracellular and intratumoral heterogeneity.
Colorectal Neoplasms
KRAS and BRAF Mutations and PTEN Expression Do Not Predict Efficacy of Cetuximab-Based Chemoradiotherapy in Locally Advanced Rectal Cancer.
Colorectal Neoplasms
Long noncoding RNA Linc02023 regulates PTEN stability and suppresses tumorigenesis of colorectal cancer in a PTEN-dependent pathway.
Colorectal Neoplasms
MicroRNA 26b promotes colorectal cancer metastasis by downregulating phosphatase and tensin homolog and wingless-type MMTV integration site family member 5A.
Colorectal Neoplasms
MicroRNA-21 controls hTERT via PTEN in human colorectal cancer cell proliferation.
Colorectal Neoplasms
MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2).
Colorectal Neoplasms
MicroRNA-32 (miR-32) regulates phosphatase and tensin homologue (PTEN) expression and promotes growth, migration, and invasion in colorectal carcinoma cells.
Colorectal Neoplasms
MicroRNA-582 promotes tumorigenesis by targeting phosphatase and tensin homologue in colorectal cancer.
Colorectal Neoplasms
MicroRNAs that regulate PTEN as potential biomarkers in colorectal cancer: a systematic review.
Colorectal Neoplasms
MiR-21 regulates biological behavior through the PTEN/PI-3 K/Akt signaling pathway in human colorectal cancer cells.
Colorectal Neoplasms
miR?494 is an independent prognostic factor and promotes cell migration and invasion in colorectal cancer by directly targeting PTEN.
Colorectal Neoplasms
NHERF1/EBP50 controls morphogenesis of 3D colonic glands by stabilizing PTEN and ezrin-radixin-moesin proteins at the apical membrane.
Colorectal Neoplasms
Phosphatase and tensin homolog expression related to cetuximab effects in colorectal cancer patients: a meta-analysis.
Colorectal Neoplasms
Prognostic impact and the relevance of PTEN copy number alterations in patients with advanced colorectal cancer (CRC) receiving bevacizumab.
Colorectal Neoplasms
PTEN mutation, loss of heterozygosity, promoter methylation and expression in colorectal carcinoma: Two hits on the gene?
Colorectal Neoplasms
PTEN status in advanced colorectal cancer treated with cetuximab.
Colorectal Neoplasms
Relationship between expression and prognostic ability of PTEN, STAT3 and VEGF-C in colorectal cancer.
Colorectal Neoplasms
Restoration of PTEN activity decreases metastases in an orthotopic model of colon cancer.
Colorectal Neoplasms
Serum levels of PTEN mRNA in colorectal cancer: a case-control study.
Colorectal Neoplasms
The association of phosphatase and tensin homolog deleted on chromosome 10 polymorphisms and lifestyle habits with colorectal cancer risk in a Chinese population.
Colorectal Neoplasms
The PTEN phosphatase controls intestinal epithelial cell polarity and barrier function: role in colorectal cancer progression.
Colorectal Neoplasms
The relationship between and clinical significance of MicroRNA-32 and phosphatase and tensin homologue expression in colorectal cancer.
Colorectal Neoplasms
The roles of microbial products in the development of colorectal cancer: a review.
Colorectal Neoplasms
Transcription factor forkhead box K1 regulates miR-32 expression and enhances cell proliferation in colorectal cancer.
Coronary Stenosis
Serum Exosomal MicroRNA-21, MicroRNA-126, and PTEN Are Novel Biomarkers for Diagnosis of Acute Coronary Syndrome.
Crohn Disease
Activation of PI3K/Akt/mTOR signaling pathway triggered by PTEN downregulation in the pathogenesis of Crohn's disease.
Diabetes Mellitus
Relevance of insulin-like growth factor 2 in the etiopathophysiology of diabetic nephropathy: possible roles of phosphatase and tensin homolog on chromosome 10 and secreted protein acidic and rich in cysteine as regulators of repair.
Diabetes Mellitus, Type 2
Relevance of insulin-like growth factor 2 in the etiopathophysiology of diabetic nephropathy: possible roles of phosphatase and tensin homolog on chromosome 10 and secreted protein acidic and rich in cysteine as regulators of repair.
Diabetes, Gestational
Increased Plasma Levels of FABP4 and PTEN Is Associated with More Severe Insulin Resistance in Women with Gestational Diabetes Mellitus.
Diabetic Nephropathies
Podocyte-Specific Knockin of PTEN Protects Kidney from Hyperglycemia.
Diabetic Nephropathies
Protein phosphatases and podocyte function.
Diabetic Nephropathies
Relevance of insulin-like growth factor 2 in the etiopathophysiology of diabetic nephropathy: possible roles of phosphatase and tensin homolog on chromosome 10 and secreted protein acidic and rich in cysteine as regulators of repair.
Diabetic Nephropathies
[Down-regulation of PTEN expression in kidney and its role in development of diabetic nephropathy in rats].
Diabetic Retinopathy
miR-139-5p promotes neovascularization in diabetic retinopathy by regulating the phosphatase and tensin homolog.
Diabetic Retinopathy
MiR-19a inhibitor improves diabetic retinopathy in rats through PTEN/Akt/P-Akt signaling pathway.
Diffuse Intrinsic Pontine Glioma
Multi-focal sequencing of a diffuse intrinsic pontine glioma establishes PTEN loss as an early event.
Dysplastic Nevus Syndrome
Expression of Phosphatase and Tensin Homologue, phospho-Akt, and p53 in Acral Benign and Malignant Melanocytic Neoplasms (Benign Nevi, Dysplastic Nevi, and Acral Melanomas).
Encephalitis, Japanese
Pathogenicity and virulence of Japanese encephalitis virus: Neuroinflammation and neuronal cell damage.
Encephalomyelitis
Loss of Phosphatase and Tensin Homolog in APCs Impedes Th17-Mediated Autoimmune Encephalomyelitis.
Endometrial Hyperplasia
Autophagy in the physiological endometrium and cancer.
Endometrial Hyperplasia
Expression of PAX2 and PTEN Correlates to Therapy Response in Endometrial Hyperplasia.
Endometrial Hyperplasia
Immunohistochemical reaction of the glandular epithelium in endometrial hyperplasia compared to endometrial carcinoma.
Endometrial Hyperplasia
Loss of phosphatase and tensin homologue deleted on chromosome 10 and phosphorylation of mammalian target of rapamycin are associated with progesterone refractory endometrial hyperplasia.
Endometrial Hyperplasia
Overexpression of the insulin-like growth factor I receptor and activation of the AKT pathway in hyperplastic endometrium.
Endometrial Hyperplasia
Prognostic significance of estrogen and progesterone receptor expression in LNG-IUS (Mirena) treatment of endometrial hyperplasia: an immunohistochemical study.
Endometrial Hyperplasia
Study of the Association of Phosphatase and Tensin Homolog and p27 Expressions in Endometrial Hyperplasia and Carcinoma.
Endometrial Neoplasms
A phase 2 study of the oral mammalian target of rapamycin inhibitor, everolimus, in patients with recurrent endometrial carcinoma.
Endometrial Neoplasms
Abnormal structure and expression of PTEN/MMAC1 gene in human uterine cancers.
Endometrial Neoplasms
Autophagy in the physiological endometrium and cancer.
Endometrial Neoplasms
Clinical implications and prognostic value of single and combined biomarkers in endometrial carcinoma.
Endometrial Neoplasms
Conditional abrogation of transforming growth factor-? receptor 1 in PTEN-inactivated endometrium promotes endometrial cancer progression in mice.
Endometrial Neoplasms
Correlation between NDRG1 and PTEN expression in endometrial carcinoma.
Endometrial Neoplasms
Diagnostic utility of phosphatase and tensin homolog, beta-catenin, and p53 for endometrial carcinoma by thin-layer endometrial preparations.
Endometrial Neoplasms
Differential Expression and Clinical Significance of DNA Methyltransferase 3B (DNMT3B), Phosphatase and Tensin Homolog (PTEN) and Human MutL Homologs 1 (hMLH1) in Endometrial Carcinomas.
Endometrial Neoplasms
Down-regulation of miR-145 and miR-143 might be associated with DNA methyltransferase 3B overexpression and worse prognosis in endometrioid carcinomas.
Endometrial Neoplasms
Effect of mTOR inhibitors in nude mice with endometrial carcinoma and variable PTEN expression status.
Endometrial Neoplasms
Elevation of ?-3 Polyunsaturated Fatty Acids Attenuates PTEN-deficiency Induced Endometrial Cancer Development through Regulation of COX-2 and PGE2 Production.
Endometrial Neoplasms
ESR1 Gene Amplification in Endometrial Carcinomas: A Clinicopathological Analysis.
Endometrial Neoplasms
Expression of mTOR protein and its clinical significance in endometrial cancer.
Endometrial Neoplasms
Expression of p53 and PTEN in human primary endometrial carcinomas: Clinicopathological and immunohistochemical analysis and study of their concomitant expression.
Endometrial Neoplasms
Expression of phosphatase and tensin homologue in imprint smears of endometrial carcinoma.
Endometrial Neoplasms
Expression of PTTG1 and PTEN in endometrial carcinoma: correlation with tumorigenesis and progression.
Endometrial Neoplasms
Growth and activation of PI-3K/PKB and Akt by stromal cell-derived factor 1alpha in endometrial carcinoma cells with expression of suppressor endoprotein PTEN.
Endometrial Neoplasms
High-grade endometrial carcinoma: serous and grade 3 endometrioid carcinomas have different immunophenotypes and outcomes.
Endometrial Neoplasms
Immunohistochemical reaction of the glandular epithelium in endometrial hyperplasia compared to endometrial carcinoma.
Endometrial Neoplasms
Loss of heterozygosity and mutational analysis of the PTEN/MMAC1 gene in synchronous endometrial and ovarian carcinomas.
Endometrial Neoplasms
Loss of tuberous sclerosis complex-2 function and activation of mammalian target of rapamycin signaling in endometrial carcinoma.
Endometrial Neoplasms
microRNA-21 overexpression contributes to cell proliferation by targeting PTEN in endometrioid endometrial cancer.
Endometrial Neoplasms
MiR-205 inhibits cell apoptosis by targeting phosphatase and tensin homolog deleted on chromosome ten in endometrial cancer Ishikawa cells.
Endometrial Neoplasms
Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity.
Endometrial Neoplasms
Neuroendocrine Tumor of the Pancreas as a Manifestation of Cowden Syndrome: A Case Report.
Endometrial Neoplasms
Phase II Study of Temsirolimus in Women With Recurrent or Metastatic Endometrial Cancer: A Trial of the NCIC Clinical Trials Group.
Endometrial Neoplasms
Phosphatase and tensin homolog (PTEN) pseudogene expression in endometrial cancer: a conserved regulatory mechanism important in tumorigenesis?
Endometrial Neoplasms
Phosphatase and tensin homolog gene inhibits the effect induced by gonadotropin-releasing hormone subtypes in human endometrial carcinoma cells.
Endometrial Neoplasms
Promoter hypermethylation and expression of sprouty 2 in endometrial carcinoma.
Endometrial Neoplasms
PTEN deficiency sensitizes endometrioid endometrial cancer to compound PARP-PI3K inhibition but not PARP inhibition as monotherapy.
Endometrial Neoplasms
PTEN/MMAC1 mutations in endometrial cancers.
Endometrial Neoplasms
Reduced progression of endometrial hyperplasia with oral mTOR inhibition in the Pten heterozygote murine model.
Endometrial Neoplasms
Role of phosphatase PTEN in the activation of extracellular signal-regulated kinases induced by estradiol in endometrial carcinoma cells.
Endometrial Neoplasms
Somatic mutations of the PTEN/MMAC1 gene in fifteen Japanese endometrial cancers: evidence for inactivation of both alleles.
Endometrial Neoplasms
Somatic mutations of the PTEN/NMAC1 gene associated with frequent chromosomal loss detected using comparative genomic hybridization in endometrial cancer.
Endometrial Neoplasms
Steroid hormone intervenes in the endometrial tumorigenesis of pten ablation.
Endometrial Neoplasms
Structural mutation analysis of PTEN and its genotype-phenotype correlations in endometriosis and cancer.
Endometrial Neoplasms
Study of the Association of Phosphatase and Tensin Homolog and p27 Expressions in Endometrial Hyperplasia and Carcinoma.
Endometrial Neoplasms
The synergistic effect of Mig-6 and Pten ablation on endometrial cancer development and progression.
Endometrial Neoplasms
Triple-high expression of phosphatase and tensin homolog (PTEN), estrogen receptor (ER) and progesterone receptor (PR) may predict favorable prognosis for patients with Type I endometrial carcinoma.
Endometriosis
17betaE2 promotes cell proliferation in endometriosis by decreasing PTEN via NFkappaB-dependent pathway.
Endometriosis
Inducing malignant transformation of endometriosis in rats by long-term sustaining hyperestrogenemia and type II diabetes.
Endometriosis
Structural mutation analysis of PTEN and its genotype-phenotype correlations in endometriosis and cancer.
Ependymoma
Molecular genetic analysis of non-astrocytic gliomas.
Epilepsy
Effect of adenovirus-mediated overexpression of PTEN on brain oxidative damage and neuroinflammation in a rat kindling model of epilepsy.
Epilepsy
Multifocal demyelinating motor neuropathy and hamartoma syndrome associated with a de novo PTEN mutation.
Epilepsy
Neuroprotective and Anti-Inflammatory Roles of the Phosphatase and Tensin Homolog Deleted on Chromosome Ten (PTEN) Inhibition in a Mouse Model of Temporal Lobe Epilepsy.
Epilepsy
Phosphatase and Tensin Homolog (PTEN) Gene Mutations and Autism: Literature Review and a Case Report of a Patient With Cowden Syndrome, Autistic Disorder and Epilepsy.
Epilepsy
PI3K isoform-selective inhibition in neuron-specific PTEN-deficient mice rescues molecular defects and reduces epilepsy-associated phenotypes.
Epilepsy
Src/CK2/PTEN-Mediated GluN2B and CREB Dephosphorylations Regulate the Responsiveness to AMPA Receptor Antagonists in Chronic Epilepsy Rats.
Epilepsy, Temporal Lobe
Neuroprotective and Anti-Inflammatory Roles of the Phosphatase and Tensin Homolog Deleted on Chromosome Ten (PTEN) Inhibition in a Mouse Model of Temporal Lobe Epilepsy.
Epileptic Syndromes
Finding a better drug for epilepsy: the mTOR pathway as an antiepileptogenic target.
Esophageal Neoplasms
Inhibition of microRNA-21 increases radiosensitivity of esophageal cancer cells through phosphatase and tensin homolog deleted on chromosome 10 activation.
Esophageal Neoplasms
MicroRNA-20b (miR-20b) Promotes the Proliferation, Migration, Invasion, and Tumorigenicity in Esophageal Cancer Cells via the Regulation of Phosphatase and Tensin Homologue Expression.
Esophageal Neoplasms
PTEN/MMAC1 expression in esophageal squamous cell carcinomas.
Esophageal Neoplasms
The adenovirus-mediated transfer of PTEN inhibits the growth of esophageal cancer cells in vitro and in vivo.
Esophageal Squamous Cell Carcinoma
Association of genetic polymorphisms in PTEN and additional gene-gene interaction with risk of esophageal squamous cell carcinoma in Chinese Han population.
Esophageal Squamous Cell Carcinoma
Effect of PTEN Antisense Oligonucleotide on Oesophageal Squamous Cell Carcinoma Cell Lines.
Esophageal Squamous Cell Carcinoma
Herpes simplex virus type 1 VP22-mediated intercellular delivery of PTEN increases the antitumor activity of PTEN in esophageal squamous cell carcinoma cells in vitro and in vivo.
Esophageal Squamous Cell Carcinoma
MiR-624-3p Promotes Esophageal Squamous Cell Carcinoma Progression via Targeting Phosphatase and Tensin Homologue.
Esophageal Squamous Cell Carcinoma
Mutational analysis of the PTEN/MMAC1 gene in primary oesophageal squamous cell carcinomas.
Esophageal Squamous Cell Carcinoma
PTEN gene is infrequently hypermethylated in human esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
PTEN/MMAC1 expression in esophageal squamous cell carcinomas.
Esophageal Squamous Cell Carcinoma
Relationship between expression of P27, Fragile Histidine Triad (FHT), phosphatase and tensin homolog deleted on chromosome ten (PTEN), P73, and prognosis in esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
Role of microRNA-21 and effect on PTEN in Kazakh's esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
The Expression and Prognostic Impact of the PI3K/AKT/mTOR Signaling Pathway in Advanced Esophageal Squamous Cell Carcinoma.
Esophageal Squamous Cell Carcinoma
Wild-type phosphatase and tensin homolog deleted on chromosome 10 improved the sensitivity of cells to rapamycin through regulating phosphorylation of Akt in esophageal squamous cell carcinoma.
Exanthema
Phase I/II trial of erlotinib and temozolomide with radiation therapy in the treatment of newly diagnosed glioblastoma multiforme: North Central Cancer Treatment Group Study N0177.
Fanconi Anemia
The PTEN phosphatase functions cooperatively with the Fanconi anemia proteins in DNA crosslink repair.
Fatty Liver
1,8-Cineole Ameliorates Steatosis of Pten Liver Specific KO Mice via Akt Inactivation.
Fatty Liver
Non-alcoholic steatohepatitis and hepatocellular carcinoma: lessons from hepatocyte-specific phosphatase and tensin homolog (PTEN)-deficient mice.
Fatty Liver
The ménage à trois of autophagy, lipid droplets and liver disease.
Fatty Liver, Alcoholic
New liver cancer biomarkers: PI3K/AKT/mTOR pathway members and eukaryotic translation initiation factors.
Fatty Liver, Alcoholic
Phosphatase and tensin homolog is a differential diagnostic marker between nonalcoholic and alcoholic fatty liver disease.
Fragile X Syndrome
Dysregulation of Mammalian Target of Rapamycin Signaling in Mouse Models of Autism.
Fragile X Syndrome
mTOR, a Potential Target to Treat Autism Spectrum Disorder.
Fragile X Syndrome
Plasticity and mTOR: towards restoration of impaired synaptic plasticity in mTOR-related neurogenetic disorders.
Frontotemporal Lobar Degeneration
PTEN activation contributes to neuronal and synaptic engulfment by microglia in tauopathy.
Ganglioneuroma
A familial frontotemporal dementia associated with C9orf72 repeat expansion and dysplastic gangliocytoma.
Ganglioneuroma
Exome Sequencing Reveals Germline SMAD9 Mutation That Reduces Phosphatase and Tensin Homolog Expression and Is Associated With Hamartomatous Polyposis and Gastrointestinal Ganglioneuromas.
Gastrointestinal Neoplasms
Molecular mutation characteristics of mismatch and homologous recombination repair genes in gastrointestinal cancer.
Gastrointestinal Stromal Tumors
The clinical correlation of phosphatase and tensin homolog on chromosome 10, phosphorylation of AKT to an activated state, and odontogenic ameloblast-associated protein in gastrointestinal stromal tumors.
Genetic Diseases, Inborn
Hidden association of Cowden syndrome, PTEN mutation and meningioma frequency.
Genetic Diseases, Inborn
PTEN Hamartoma Tumor Syndrome: A Clinical Overview.
Gingival Overgrowth
The role of phosphatase and tensin homolog in drug-induced gingival overgrowth.
Glaucoma
TGF-? induces phosphorylation of phosphatase and tensin homolog: implications for fibrosis of the trabecular meshwork tissue in glaucoma.
Glioblastoma
10q23.3 loss of heterozygosity is higher in lymph node-positive (pT2-3,N+) versus lymph node-negative (pT2-3,N0) prostate cancer.
Glioblastoma
A curcumin-loaded polymeric micelle as a carrier of a microRNA-21 antisense-oligonucleotide for enhanced anti-tumor effects in a glioblastoma animal model.
Glioblastoma
A heterozygous germline mutation of the PTEN/MMAC1 gene in a patient with Cowden disease.
Glioblastoma
A Novel PTEN-Dependent Link to Ubiquitination Controls FLIPS Stability and TRAIL Sensitivity in Glioblastoma Multiforme.
Glioblastoma
A novel PTEN/mutant p53/c-Myc/Bcl-XL axis mediates context-dependent oncogenic effects of PTEN with implications for cancer prognosis and therapy.
Glioblastoma
A Phase Ib/II, open-label, multicenter study of INC280 (capmatinib) alone and in combination with buparlisib (BKM120) in adult patients with recurrent glioblastoma.
Glioblastoma
Akt1 activation can augment hypoxia-inducible factor-1alpha expression by increasing protein translation through a mammalian target of rapamycin-independent pathway.
Glioblastoma
Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma.
Glioblastoma
ARL4C stabilized by AKT/mTOR pathway promotes the invasion of PTEN-deficient primary human glioblastoma.
Glioblastoma
Blockade of glioma proliferation through allosteric inhibition of JAK2.
Glioblastoma
Brain Tumors of Glial Origin.
Glioblastoma
Chromosomal abnormalities in human glioblastomas: gain in chromosome 7p correlating with loss in chromosome 10q.
Glioblastoma
Cilostazol prevents tumor necrosis factor-alpha-induced cell death by suppression of phosphatase and tensin homolog deleted from chromosome 10 phosphorylation and activation of Akt/cyclic AMP response element-binding protein phosphorylation.
Glioblastoma
Combination of all-trans retinoic acid and interferon-gamma upregulated p27(kip1) and down regulated CDK2 to cause cell cycle arrest leading to differentiation and apoptosis in human glioblastoma LN18 (PTEN-proficient) and U87MG (PTEN-deficient) cells.
Glioblastoma
Combinatorial therapy with adenoviral-mediated PTEN and a PI3K inhibitor suppresses malignant glioma cell growth in vitro and in vivo by regulating the PI3K/AKT signaling pathway.
Glioblastoma
Combined PTEN Mutation and Protein Expression Associate with Overall and Disease-Free Survival of Glioblastoma Patients.
Glioblastoma
Coordinate activation of Shh and PI3K signaling in PTEN-deficient glioblastoma: new therapeutic opportunities.
Glioblastoma
Correlation of EGFR, IDH1 and PTEN status with the outcome of patients with recurrent glioblastoma treated in a phase II clinical trial with the EGFR-blocking monoclonal antibody cetuximab.
Glioblastoma
Deregulation of a STAT3-interleukin 8 signaling pathway promotes human glioblastoma cell proliferation and invasiveness.
Glioblastoma
Distinct patterns of deletion on 10p and 10q suggest involvement of multiple tumor suppressor genes in the development of astrocytic gliomas of different malignancy grades.
Glioblastoma
Effects of epidermal growth factor receptor and phosphatase and tensin homologue gene expression on the inhibition of U87MG glioblastoma cell proliferation induced by protein kinase inhibitors.
Glioblastoma
Gambogenic acid-induced time- and dose-dependent growth inhibition and apoptosis involving Akt pathway inactivation in U251 glioblastoma cells.
Glioblastoma
Genetic alteration and expression of the phosphoinositol-3-kinase/Akt pathway genes PIK3CA and PIKE in human glioblastomas.
Glioblastoma
Glioblastoma Therapy: Rationale for a Mesenchymal Stem Cell-based Vehicle to Carry Recombinant Viruses.
Glioblastoma
Glioma cell VEGFR-2 confers resistance to chemotherapeutic and antiangiogenic treatments in PTEN-deficient glioblastoma.
Glioblastoma
Identifying radiographic specificity for phosphatase and tensin homolog and epidermal growth factor receptor changes: a quantitative analysis of glioblastomas.
Glioblastoma
Immunocytochemical mapping of the phosphatase and tensin homolog (PTEN/MMAC1) tumor suppressor protein in human gliomas.
Glioblastoma
Increased expression of Mcl-1 is required for protection against serum starvation in phosphatase and tensin homologue on chromosome 10 null mouse embryonic fibroblasts, but repression of Bim is favored in human glioblastomas.
Glioblastoma
Inhibition of phosphatidylinositol-3-OH kinase/Akt signaling impairs DNA repair in glioblastoma cells following ionizing radiation.
Glioblastoma
Involvement of Phosphatase and Tensin Homolog in Cyclin-Dependent Kinase 4/6 Inhibitor-Induced Blockade of Glioblastoma.
Glioblastoma
KAP regulates ROCK2 and Cdk2 in an RNA-activated glioblastoma invasion pathway.
Glioblastoma
Mechanism of action studies of lomaiviticin A and the monomeric lomaiviticin aglycon. Selective and potent activity toward DNA double-strand break repair-deficient cell lines.
Glioblastoma
Mechanisms of stearoyl CoA desaturase inhibitor sensitivity and acquired resistance in cancer.
Glioblastoma
miR-144-3p exerts anti-tumor effects in glioblastoma by targeting c-Met.
Glioblastoma
Molecular diagnostics of gliomas using next generation sequencing of a glioma-tailored gene panel.
Glioblastoma
Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in primary breast carcinomas.
Glioblastoma
Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity.
Glioblastoma
Myristoylated alanine-rich C-kinase substrate effector domain phosphorylation regulates the growth and radiation sensitization of glioblastoma.
Glioblastoma
Phase II study of bevacizumab and temsirolimus combination therapy for recurrent glioblastoma multiforme.
Glioblastoma
Phosphatase and tensin homolog reconstruction and vascular endothelial growth factor knockdown synergistically inhibit the growth of glioblastoma.
Glioblastoma
Phosphatase and tensin homologue deficiency in glioblastoma confers resistance to radiation and temozolomide that is reversed by the protease inhibitor nelfinavir.
Glioblastoma
Phosphatase and tensin homologue deleted on chromosome 10.
Glioblastoma
Prognosis of patients with multifocal glioblastoma: a case-control study.
Glioblastoma
Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC.
Glioblastoma
PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry.
Glioblastoma
PTEN restoration and PIK3CB knockdown synergistically suppress glioblastoma growth in vitro and in xenografts.
Glioblastoma
PTEN, NHERF1 and PHLPP form a tumor suppressor network that is disabled in glioblastoma.
Glioblastoma
PTEN/MMAC1 mutations and EGFR amplification in glioblastomas.
Glioblastoma
PTEN/MMAC1 mutations in primary glioblastomas and short-term cultures of malignant gliomas.
Glioblastoma
Role of PTEN in cholera toxin-induced SWO?38 glioma cell differentiation.
Glioblastoma
Roles of the functional loss of p53 and other genes in astrocytoma tumorigenesis and progression.
Glioblastoma
S1P(2) receptors mediate inhibition of glioma cell migration through Rho signaling pathways independent of PTEN.
Glioblastoma
Short interfering RNA-induced gene silencing is transmitted between cells from the mammalian central nervous system.
Glioblastoma
Stabilization of phosphofructokinase 1 platelet isoform by AKT promotes tumorigenesis.
Glioblastoma
STAT3-iNOS Signaling Mediates EGFRvIII-Induced Glial Proliferation and Transformation.
Glioblastoma
Targeting the mTOR pathway using novel ATP?competitive inhibitors, Torin1, Torin2 and XL388, in the treatment of glioblastoma.
Glioblastoma
The catalytic phosphoinositol 3-kinase isoform p110? is required for glioma cell migration and invasion.
Glioblastoma
Translational Nanomedicine Boosts Anti-PD1 Therapy to Eradicate Orthotopic PTEN-Negative Glioblastoma.
Glioma
A role for nuclear PTEN in neuronal differentiation.
Glioma
A Short Region of Connexin43 Reduces Human Glioma Stem Cell Migration, Invasion, and Survival through Src, PTEN, and FAK.
Glioma
Analysis of the activation status of Akt, NFkappaB, and Stat3 in human diffuse gliomas.
Glioma
Characterization and response of newly developed high-grade glioma cultures to the tyrosine kinase inhibitors, erlotinib, gefitinib and imatinib.
Glioma
Denaturing high performance liquid chromatography (DHPLC) used in the detection of germline and somatic mutations.
Glioma
Dexamethasone Interferes with Autophagy and Affects Cell Survival in Irradiated Malignant Glioma Cells.
Glioma
Different response of human glioma tumor-initiating cells to epidermal growth factor receptor kinase inhibitors.
Glioma
Dinaciclib, a Cyclin-Dependent Kinase Inhibitor Promotes Proteasomal Degradation of Mcl-1 and Enhances ABT-737-Mediated Cell Death in Malignant Human Glioma Cell Lines.
Glioma
Downregulation of Spry2 by miR-21 triggers malignancy in human gliomas.
Glioma
FGFR2-mediated phosphorylation of PTEN at tyrosine 240 contributes to the radioresistance of glioma.
Glioma
Germline mutations of p53 but not p16/CDKN2 or PTEN/MMAC1 tumor suppressor genes predispose to gliomas. The ANOCEF Group. Association des NeuroOncologues d'Expression Française.
Glioma
Hypoxia regulates the expression of tissue factor pathway signaling elements in a rat glioma model.
Glioma
Identification of PTEN/MMAC1 alterations in uncultured melanomas and melanoma cell lines.
Glioma
Identifying radiographic specificity for phosphatase and tensin homolog and epidermal growth factor receptor changes: a quantitative analysis of glioblastomas.
Glioma
Immunocytochemical mapping of the phosphatase and tensin homolog (PTEN/MMAC1) tumor suppressor protein in human gliomas.
Glioma
Is exon 5 of the PTEN/MMAC1 gene a prognostic marker in anaplastic glioma?
Glioma
Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation.
Glioma
Letter regarding Xiao WZ et al. entitled "Relationships between PTEN gene mutations and prognosis in glioma: a meta-analysis".
Glioma
LncRNA ANCR promotes glioma cells invasion, migration, proliferation and inhibits apoptosis via interacting with EZH2 and repressing PTEN expression.
Glioma
Long Non-Coding RNA PART1 Exerts Tumor Suppressive Functions in Glioma via Sponging miR-190a-3p and Inactivation of PTEN/AKT Pathway.
Glioma
Long non-coding RNA TUG1 acts as a miR-26a sponge in human glioma cells.
Glioma
Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma.
Glioma
Mammalian Target of Rapamycin Signaling Pathway Contributes to Glioma Progression and Patients' Prognosis.
Glioma
Management and survival rates in patients with glioma in China (2004-2010): a retrospective study from a single-institution.
Glioma
Mechanisms of action of rapamycin in gliomas.
Glioma
MicroRNA-379 inhibits cell proliferation and invasion in glioma via targeting metadherin and regulating PTEN/AKT pathway.
Glioma
MicroRNA?494 promotes the proliferation and migration of human glioma cancer cells through the protein kinase B/mechanistic target of rapamycin pathway by phosphatase and tensin homolog expression.
Glioma
MiR-130b can suppress proliferation of glioma cells through targeting PTEN to regulate AKT pathway.
Glioma
miR-21 Is Linked to Glioma Angiogenesis: A Co-Localization Study.
Glioma
MiR-4310 induced by SP1 targets PTEN to promote glioma progression.
Glioma
Molecular diagnostics of gliomas using next generation sequencing of a glioma-tailored gene panel.
Glioma
Molecular genetic analysis of phosphatase and tensin homolog and p16 tumor suppressor genes in patients with malignant glioma.
Glioma
Multi-focal sequencing of a diffuse intrinsic pontine glioma establishes PTEN loss as an early event.
Glioma
Mutation in the PTEN/MMAC1 gene in archival low grade and high grade gliomas.
Glioma
Mutations of PTEN gene in gliomas correlate to tumor differentiation and short-term survival rate.
Glioma
Overexpressed let-7a inhibits glioma cell malignancy by directly targeting K-ras, independently of PTEN.
Glioma
Phosphatase and Tensin Homolog Mutation in Immune Cell Infiltration and Clinicopathological Features of Low-Grade Gliomas.
Glioma
Photochemical internalization-mediated nonviral gene transfection: polyamine core-shell nanoparticles as gene carrier.
Glioma
PI3K activation in neural stem cells drives tumorigenesis which can be ameliorated by targeting the cAMP response element binding protein.
Glioma
Point mutation and homozygous deletion of PTEN/MMAC1 in primary bladder cancers.
Glioma
PTEN decreases in vivo vascularization of experimental gliomas in spite of proangiogenic stimuli.
Glioma
PTEN gene mutations correlate to poor prognosis in glioma patients: a meta-analysis.
Glioma
PTEN loss compromises homologous recombination repair in astrocytes: implications for glioblastoma therapy with temozolomide or poly(ADP-ribose) polymerase inhibitors.
Glioma
PTEN regulation of neural development and CNS stem cells.
Glioma
PTEN status switches cell fate between premature senescence and apoptosis in glioma exposed to ionizing radiation.
Glioma
PTEN-mRNA engineered mesenchymal stem cell-mediated cytotoxic effects on U251 glioma cells.
Glioma
PTEN/MMAC1 in malignant melanoma and its importance for tumor progression.
Glioma
PTEN/MMAC1 mutations in primary glioblastomas and short-term cultures of malignant gliomas.
Glioma
Relative reciprocity of NRAS and PTEN/MMAC1 alterations in cutaneous melanoma cell lines.
Glioma
Role of PTEN in cholera toxin-induced SWO?38 glioma cell differentiation.
Glioma
Somatic deletion mapping on chromosome 10 and sequence analysis of PTEN/MMAC1 point to the 10q25-26 region as the primary target in low-grade and high-grade gliomas.
Glioma
Somatic mutation of PTEN in bladder carcinoma.
Glioma
STAT3 Activation in Glioblastoma: Biochemical and Therapeutic Implications.
Glioma
Structural and functional evidence for the presence of tumor suppressor genes on the short arm of chromosome 10 in human gliomas.
Glioma
Synergistic interaction between 17-AAG and phosphatidylinositol 3-kinase inhibition in human malignant glioma cells.
Glioma
Temozolomide and AZD7762 Induce Synergistic Cytotoxicity Effects on Human Glioma Cells.
Glioma
The effect of PTEN on proliferation and drug-, and radiosensitivity in malignant glioma cells.
Glioma
The Effect of Silibinin in Enhancing Toxicity of Temozolomide and Etoposide in p53 and PTEN-mutated Resistant Glioma Cell Lines.
Glioma
The expression of PTEN in the development of mouse cochlear lateral wall.
Glioma
The functional role of tumor suppressor genes in gliomas: clues for future therapeutic strategies.
Glioma
The protein phosphatase activity of PTEN regulates SRC family kinases and controls glioma migration.
Glioma
The role of the PTEN gene in malignant gliomas.
Glioma
Use of telomerase promoter mutations to mark specific molecular subsets with reciprocal clinical behavior in IDH mutant and IDH wild-type diffuse gliomas.
Glomerulonephritis, Membranous
Altered expression of serum miR-106a, miR-19b, miR-17, and PTEN in patients with idiopathic membranous nephropathy.
Glucose Intolerance
PTEN upregulation may explain the development of insulin resistance and type 2 diabetes with high dose statins.
Goiter
Thyroid involvement in two patients with Bannayan-Riley-Ruvalcaba syndrome.
Hamartoma
A case of Cowden syndrome diagnosed from multiple gastric polyposis.
Hamartoma
A case of follicular thyroid carcinoma associated with phosphatase and tensin homologue hamartoma tumour syndrome.
Hamartoma
AKT activation promotes PTEN hamartoma tumor syndrome-associated cataract development.
Hamartoma
Assessment of PTEN-associated vascular malformations in a patient with Bannayan-Riley-Ruvalcaba syndrome.
Hamartoma
Autosomal Dominant Inherited Cowden's Disease in a Family.
Hamartoma
Balancing Proliferation and Connectivity in PTEN-associated Autism Spectrum Disorder.
Hamartoma
Bannayan-Riley-Ruvalcaba Syndrome in a Patient with a PTEN Mutation Identified by Chromosomal Microarray Analysis: A Case Report.
Hamartoma
Clinical and sonographic features of pediatric soft-tissue vascular anomalies part 2: vascular malformations.
Hamartoma
Clinicopathologic and Molecular Analysis of a Choroidal Pigmented Schwannoma in the Context of a PTEN Hamartoma Tumor Syndrome.
Hamartoma
Colonic manifestations of PTEN hamartoma tumor syndrome: case series and systematic review.
Hamartoma
Colonic polyps and polyposis syndromes in pediatric patients.
Hamartoma
Cowden syndrome and the PTEN hamartoma tumor syndrome: systematic review and revised diagnostic criteria.
Hamartoma
Cowden syndrome- Clinico-radiological illustration of a rare case.
Hamartoma
Dermatofibrosarcoma Protuberans in a Patient With Cowden Syndrome: Revisiting the PTEN and PDGF Pathways.
Hamartoma
Dynamics and structural stability effects of germline PTEN mutations associated with cancer versus autism phenotypes.
Hamartoma
Endoscopic Findings in Patients With PTEN Hamartoma Tumor Syndrome Undergoing Surveillance.
Hamartoma
Genodermatosis Affecting the Skin and Mucosa of the Head and Neck: Clinicopathologic, Genetic, and Molecular Aspect-PTEN-Hamartoma Tumor Syndrome/Cowden Syndrome.
Hamartoma
Germline PTEN mutations are associated with a skewed peripheral immune repertoire in humans and mice.
Hamartoma
Giant Cerebral Aneurysm in a Patient with Cowden Syndrome Treated with Surgical Clipping.
Hamartoma
Hamartomatous polyposis syndromes.
Hamartoma
Hidden association of Cowden syndrome, PTEN mutation and meningioma frequency.
Hamartoma
mTOR, a Potential Target to Treat Autism Spectrum Disorder.
Hamartoma
Mutation and allelic loss of the PTEN/MMAC1 gene in primary and metastatic melanoma biopsies.
Hamartoma
Mutational abrogation of the PTEN/MMAC1 gene in gastrointestinal polyps in patients with Cowden disease.
Hamartoma
Oncophenotypic review and clinical correlates of phosphatase and tensin homolog on chromosome 10 hamartoma tumor syndrome.
Hamartoma
Oral manifestations of phosphatase and tensin homolog hamartoma tumor syndrome: a report of three cases.
Hamartoma
Phosphatase and Tensin Homolog Hamartoma Tumor Syndrome: A Case Report.
Hamartoma
Plasticity and mTOR: towards restoration of impaired synaptic plasticity in mTOR-related neurogenetic disorders.
Hamartoma
Prevalence and clinical/molecular characteristics of PTEN mutations in Turkish children with autism spectrum disorders and macrocephaly.
Hamartoma
PTEN hamartoma of the soft tissue: the initial manifestation of an underlying PTEN hamartoma tumor syndrome in a 4-year-old female.
Hamartoma
PTEN Hamartoma Tumor Syndrome: A Clinical Overview.
Hamartoma
PTEN in Hereditary and Sporadic Cancer.
Hamartoma
PTEN Lipid Phosphatase Activity and Proper Subcellular Localization Are Necessary and Sufficient for Down-Regulating AKT Phosphorylation in the Nucleus in Cowden Syndrome.
Hamartoma
PTEN suppresses breast cancer cell growth by phosphatase activity-dependent G1 arrest followed by cell death.
Hamartoma
Pulmonary atypical carcinoid in a patient with Cowden syndrome.
Hamartoma
Resveratrol Potentiates Growth Inhibitory Effects of Rapamycin in PTEN-deficient Lipoma Cells by Suppressing p70S6 Kinase Activity.
Hamartoma
Retinal astrocytoma in a young male with PTEN hamartoma tumor syndrome.
Hamartoma
Temporal Evolution and Management of Fast Flow Vascular Anomalies in PTEN Hamartoma Tumor Syndrome.
Hamartoma
The Clinical Spectrum of PTEN Hamartoma Tumor Syndrome: Exploring the Value of Thyroid Surveillance.
Hamartoma
The Skin in Cowden Syndrome.
Hamartoma
Thyroid Nodules and Cancer in Children with PTEN Hamartoma Tumor Syndrome.
Hamartoma
Unrestrained mammalian target of rapamycin complexes 1 and 2 increase expression of phosphatase and tensin homolog deleted on chromosome 10 to regulate phosphorylation of Akt kinase.
Hamartoma
Variable expressivity and novel PTEN mutations in Cowden syndrome.
Hamartoma
WWP1 Gain-of-Function Inactivation of PTEN in Cancer Predisposition.
Hamartoma
[Hereditary colorectal cancer : An update on genetics and entities in terms of differential diagnosis].
Hamartoma Syndrome, Multiple
A case of Cowden syndrome diagnosed from multiple gastric polyposis.
Hamartoma Syndrome, Multiple
A heterozygous frameshift mutation of the PTEN/MMAC1 gene in a patient with Lhermitte-Duclos disease - only the mutated allele was expressed in the cerebellar tumor.
Hamartoma Syndrome, Multiple
A heterozygous germline mutation of the PTEN/MMAC1 gene in a patient with Cowden disease.
Hamartoma Syndrome, Multiple
A novel germline mutation of the PTEN/MMAC1 gene in a patient with Cowden disease.
Hamartoma Syndrome, Multiple
A novel PTEN gene promoter mutation and untypical Cowden syndrome.
Hamartoma Syndrome, Multiple
Absence of PTEN/MMAC1 germ-line mutations in sporadic Bannayan-Riley-Ruvalcaba syndrome.
Hamartoma Syndrome, Multiple
Accelerated decline of blood glucose after intravenous glucose injection in a patient with Cowden disease having a heterozygous germline mutation of the PTEN/MMAC1 gene.
Hamartoma Syndrome, Multiple
AKT activation promotes PTEN hamartoma tumor syndrome-associated cataract development.
Hamartoma Syndrome, Multiple
Androgen actions via androgen receptor promote PTEN inactivation induced uterine cancer.
Hamartoma Syndrome, Multiple
Association between Cowden syndrome and Lhermitte-Duclos disease: report of two cases and review of the literature.
Hamartoma Syndrome, Multiple
Autosomal Dominant Inherited Cowden's Disease in a Family.
Hamartoma Syndrome, Multiple
Bannayan-Riley-Ruvalcaba Syndrome in a Patient with a PTEN Mutation Identified by Chromosomal Microarray Analysis: A Case Report.
Hamartoma Syndrome, Multiple
Breast Cancer and Non-Hodgkin Lymphoma in a Young Male with Cowden Syndrome.
Hamartoma Syndrome, Multiple
Clinicopathologic and Molecular Analysis of a Choroidal Pigmented Schwannoma in the Context of a PTEN Hamartoma Tumor Syndrome.
Hamartoma Syndrome, Multiple
Cowden syndrome and the PTEN hamartoma tumor syndrome: systematic review and revised diagnostic criteria.
Hamartoma Syndrome, Multiple
Cowden Syndrome with a Novel Germline PTEN Mutation and an Unusual Clinical Course.
Hamartoma Syndrome, Multiple
Cowden syndrome- Clinico-radiological illustration of a rare case.
Hamartoma Syndrome, Multiple
Cowden's syndrome with immunodeficiency.
Hamartoma Syndrome, Multiple
Dermatofibrosarcoma Protuberans in a Patient With Cowden Syndrome: Revisiting the PTEN and PDGF Pathways.
Hamartoma Syndrome, Multiple
Differential expression of PTEN-targeting microRNAs miR-19a and miR-21 in Cowden syndrome.
Hamartoma Syndrome, Multiple
Dynamics and structural stability effects of germline PTEN mutations associated with cancer versus autism phenotypes.
Hamartoma Syndrome, Multiple
Enhanced lymphocyte interferon (IFN)-? responses in a PTEN mutation-negative Cowden disease kindred.
Hamartoma Syndrome, Multiple
Epithelial-specific loss of PTEN results in colorectal juvenile polyp formation and invasive cancer.
Hamartoma Syndrome, Multiple
Finding a better drug for epilepsy: the mTOR pathway as an antiepileptogenic target.
Hamartoma Syndrome, Multiple
Frequent Gastrointestinal Polyps and Colorectal Adenocarcinomas in a Prospective Series of PTEN Mutation Carriers.
Hamartoma Syndrome, Multiple
From developmental disorder to heritable cancer: it's all in the BMP/TGF-beta family.
Hamartoma Syndrome, Multiple
Genetic basis of Cowden syndrome and its implications for clinical practice and risk management.
Hamartoma Syndrome, Multiple
Genetics of endometrial cancer.
Hamartoma Syndrome, Multiple
Genodermatosis Affecting the Skin and Mucosa of the Head and Neck: Clinicopathologic, Genetic, and Molecular Aspect-PTEN-Hamartoma Tumor Syndrome/Cowden Syndrome.
Hamartoma Syndrome, Multiple
Germline epigenetic regulation of KILLIN in Cowden and Cowden-like syndrome.
Hamartoma Syndrome, Multiple
Germline mutations in the PTEN/MMAC1 gene in patients with Cowden disease.
Hamartoma Syndrome, Multiple
Germline mutations of the PTEN/MMAC1 gene in Japanese patients with Cowden disease.
Hamartoma Syndrome, Multiple
Germline PTEN mutations are associated with a skewed peripheral immune repertoire in humans and mice.
Hamartoma Syndrome, Multiple
Giant Cerebral Aneurysm in a Patient with Cowden Syndrome Treated with Surgical Clipping.
Hamartoma Syndrome, Multiple
Hereditary breast cancer.
Hamartoma Syndrome, Multiple
Infantile Lhermitte-Duclos Disease Treated Successfully With Rapamycin.
Hamartoma Syndrome, Multiple
Insulin resistance and exaggerated insulin sensitivity triggered by single-gene mutations in the insulin signaling pathway.
Hamartoma Syndrome, Multiple
Intermediate uveitis in a child with phosphatase and tensin homolog gene mutation and Bannayan-Riley-Ruvalcaba syndrome.
Hamartoma Syndrome, Multiple
Lhermitte-Duclos disease with neurofibrillary tangles in heterotopic cerebral grey matter.
Hamartoma Syndrome, Multiple
Mosaic partial deletion of the PTEN gene in a patient with Cowden syndrome.
Hamartoma Syndrome, Multiple
Mutation analysis of PTEN/MMAC 1 in sporadic thyroid tumors.
Hamartoma Syndrome, Multiple
Mutation and allelic loss of the PTEN/MMAC1 gene in primary and metastatic melanoma biopsies.
Hamartoma Syndrome, Multiple
Mutational abrogation of the PTEN/MMAC1 gene in gastrointestinal polyps in patients with Cowden disease.
Hamartoma Syndrome, Multiple
Neuroendocrine Tumor of the Pancreas as a Manifestation of Cowden Syndrome: A Case Report.
Hamartoma Syndrome, Multiple
Novel PTEN mutation in Cowden syndrome: case report with late diagnosis and non-malignant course.
Hamartoma Syndrome, Multiple
Oral manifestations of phosphatase and tensin homolog hamartoma tumor syndrome: a report of three cases.
Hamartoma Syndrome, Multiple
Phosphatase and Tensin Homolog (PTEN) Gene Mutations and Autism: Literature Review and a Case Report of a Patient With Cowden Syndrome, Autistic Disorder and Epilepsy.
Hamartoma Syndrome, Multiple
Phosphatase and Tensin Homolog Hamartoma Tumor Syndrome: A Case Report.
Hamartoma Syndrome, Multiple
Phosphatase and tensin homolog immunohistochemical staining and clinical criteria for Cowden syndrome in patients with trichilemmoma or associated lesions.
Hamartoma Syndrome, Multiple
Point mutation and homozygous deletion of PTEN/MMAC1 in primary bladder cancers.
Hamartoma Syndrome, Multiple
Primary lung adenocarcinoma occurring in a PTEN related syndrome (Cowden's disease): routine EGFR sequencing also highlights two rare somatic mutations S768I and V769L.
Hamartoma Syndrome, Multiple
PTEN in Hereditary and Sporadic Cancer.
Hamartoma Syndrome, Multiple
PTEN Lipid Phosphatase Activity and Proper Subcellular Localization Are Necessary and Sufficient for Down-Regulating AKT Phosphorylation in the Nucleus in Cowden Syndrome.
Hamartoma Syndrome, Multiple
PTEN suppresses breast cancer cell growth by phosphatase activity-dependent G1 arrest followed by cell death.
Hamartoma Syndrome, Multiple
PTEN/MMAC1 mutations in endometrial cancers.
Hamartoma Syndrome, Multiple
Pulmonary atypical carcinoid in a patient with Cowden syndrome.
Hamartoma Syndrome, Multiple
Rapamycin prevents, but does not reverse, aberrant migration in Pten knockout neurons.
Hamartoma Syndrome, Multiple
Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway.
Hamartoma Syndrome, Multiple
Somatic mutations of the PTEN/MMAC1 gene in fifteen Japanese endometrial cancers: evidence for inactivation of both alleles.
Hamartoma Syndrome, Multiple
SUMO, PTEN and Tumor Suppression.
Hamartoma Syndrome, Multiple
The Skin in Cowden Syndrome.
Hamartoma Syndrome, Multiple
Variable expressivity and novel PTEN mutations in Cowden syndrome.
Hamartoma Syndrome, Multiple
WWP1 Gain-of-Function Inactivation of PTEN in Cancer Predisposition.
Hamartoma Syndrome, Multiple
[A Case of Cowden Syndrome Associated with Lhermitte-Duclos Disease].
Head and Neck Neoplasms
Analysis of PTEN/MMAC1 alterations in aerodigestive tract tumors.
Head and Neck Neoplasms
The phosphatase and tensin homologue deleted on chromosome 10 mediates radiosensitivity in head and neck cancer.
Hearing Loss, Sensorineural
PRDX1 activates autophagy via the PTEN-AKT signaling pathway to protect against cisplatin-induced spiral ganglion neuron damage.
Heart Failure
Nuclear miR-665 aggravates heart failure via suppressing phosphatase and tensin homolog transcription.
Heart Failure
PTEN Inhibitor VO-OHpic Attenuates Inflammatory M1 Macrophages and Cardiac Remodeling in Doxorubicin-Induced Cardiomyopathy.
Hemangioma
Aberrant PTEN, PIK3CA, pMAPK, and TP53 expression in human scalp and face angiosarcoma.
Hemangioma, Cavernous, Central Nervous System
Phosphatase and tensin homolog in cerebral cavernous malformation: a potential role in pathological angiogenesis.
Hemangiosarcoma
Aberrant PTEN, PIK3CA, pMAPK, and TP53 expression in human scalp and face angiosarcoma.
Hemangiosarcoma
Alterations of the p53 and PIK3CA/AKT/mTOR pathways in angiosarcomas: A pattern distinct from other sarcomas with complex genomics.
Hemangiosarcoma
Mutations of phosphatase and tensin homolog deleted from chromosome 10 in canine hemangiosarcoma.
Hematologic Neoplasms
Contributions of the Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways to leukemia.
Hematologic Neoplasms
Pivotal role of Pten in the balance between proliferation and differentiation of hematopoietic stem cells in zebrafish.
Hematologic Neoplasms
Pten regulates homeostasis and inflammation-induced migration of myelocytes in zebrafish.
Hepatitis B
Hepatitis B Virus Induces Cell Proliferation via HBx-Induced microRNA-21 in Hepatocellular Carcinoma by Targeting Programmed Cell Death Protein4 (PDCD4) and Phosphatase and Tensin Homologue (PTEN).
Hepatitis B, Chronic
Hepatitis B virus-triggered PTEN/?-catenin/c-Myc signaling enhances PD-L1 expression to promote immune evasion.
Hepatitis B, Chronic
New liver cancer biomarkers: PI3K/AKT/mTOR pathway members and eukaryotic translation initiation factors.
Hepatitis C
Hepatitis C virus NS5A drives a PTEN-PI3K/Akt feedback loop to support cell survival.
Hepatitis C, Chronic
New liver cancer biomarkers: PI3K/AKT/mTOR pathway members and eukaryotic translation initiation factors.
Hepatomegaly
Non-alcoholic steatohepatitis and hepatocellular carcinoma: lessons from hepatocyte-specific phosphatase and tensin homolog (PTEN)-deficient mice.
Hepatomegaly
Oral intake of genetically engineered high-carotenoid corn ameliorates hepatomegaly and hepatic steatosis in PTEN haploinsufficient mice.
Hyperglycemia
Kidney glycosphingolipids are elevated early in diabetic nephropathy and mediate hypertrophy of mesangial cells.
Hyperinsulinism
The influence of diabetes in the pathogenesis and the clinical course of hepatocellular carcinoma: recent findings and new perspectives.
Hypersensitivity
Protein phosphatase 5 and the tumor suppressor P53 down-regulate each other's activities in mice.
Hypersensitivity
Saturated Fatty Acid-induced cytotoxicity in liver cells does not involve phosphatase and tensin homologue deleted on chromosome 10.
Hypertension
Myeloid PTEN deficiency aggravates renal inflammation and fibrosis in angiotensin II-induced hypertension.
Hypertension
Prostaglandin E1 Attenuates Pulmonary Artery Remodeling by Activating Phosphorylation of CREB and the PTEN Signaling Pathway.
Hypertension, Pulmonary
5-Aza-2'-deoxycytidine, a DNA methylation inhibitor, attenuates hypoxic pulmonary hypertension via demethylation of the PTEN promoter.
Hypertrophy, Right Ventricular
Deficiency of Akt1, but not Akt2, attenuates the development of pulmonary hypertension.
Idiopathic Pulmonary Fibrosis
Phosphatase and tensin homolog deleted on chromosome 10 contributes to phenotype transformation of fibroblasts in idiopathic pulmonary fibrosis via multiple pathways.
Infections
BMI1 promotes cardiac fibrosis in ischemia-induced heart failure via the PTEN-PI3K/Akt-mTOR signaling pathway.
Infections
Human Immunodeficiency Virus Type 1 Induces Lytic Cycle Replication of Kaposi's-Sarcoma-Associated Herpesvirus: Role of Ras/c-Raf/MEK1/2, PI3K/AKT, and NF-?B Signaling Pathways.
Infections
MicroRNA-21 drives severe, steroid-insensitive experimental asthma by amplifying phosphoinositide 3-kinase-mediated suppression of histone deacetylase 2.
Infections
Phosphatase and Tensin Homolog (PTEN) of Japanese Flounder-Its Regulation by miRNA and Role in Autophagy, Apoptosis and Pathogen Infection.
Infections
PTEN Lipid Phosphatase Activity Enhances Dengue Virus Production through Akt/FoxO1/Maf1 Signaling.
Infections
Schistosoma japonicum Infection Leads to the Reprogramming of Glucose and Lipid Metabolism in the Colon of Mice.
Infections
The Phosphatidylinositol 3-Kinase p110?/PTEN Signaling Pathway Is Crucial for HIV-1 Entry.
Infertility
Intraovarian control of early folliculogenesis.
Inflammatory Bowel Diseases
The roles of microbial products in the development of colorectal cancer: a review.
Insulin Resistance
A common variation of the PTEN gene is associated with peripheral insulin resistance.
Insulin Resistance
Biochemical and molecular evidence on the role of vaspin in early detection of the insulin resistance in a rat model of high-fat diet and use of diazinon.
Insulin Resistance
Calorie restriction prevents the development of insulin resistance and impaired lipid metabolism in gestational diabetes offspring.
Insulin Resistance
GPR55 deficiency is associated with increased adiposity and impaired insulin signaling in peripheral metabolic tissues.
Insulin Resistance
Icariin Attenuates Amyloid-? (A?)-Induced Neuronal Insulin Resistance Through PTEN Downregulation.
Insulin Resistance
Increase of PTEN gene expression in insulin resistance.
Insulin Resistance
Increased Plasma Levels of FABP4 and PTEN Is Associated with More Severe Insulin Resistance in Women with Gestational Diabetes Mellitus.
Insulin Resistance
Insulin sensitization causes accelerated sinus nodal dysfunction through autophagic dysregulation in hypertensive mice.
Insulin Resistance
Insulin Signaling in Insulin Resistance States and Cancer: A Modeling Analysis.
Insulin Resistance
IRS2 and PTEN are key molecules in controlling insulin sensitivity in podocytes.
Insulin Resistance
Metformin sensitizes insulin signaling through AMPK-mediated pten down-regulation in preadipocyte 3T3-L1 cells.
Insulin Resistance
miR-18a increases insulin sensitivity by inhibiting PTEN.
Insulin Resistance
MiRNA-21 Reverses High Glucose and High Insulin Induced Insulin Resistance in 3T3-L1 Adipocytes through Targeting Phosphatase and Tensin Homologue.
Insulin Resistance
Peroxisome proliferator-activated receptor-gamma agonist improves skeletal muscle insulin signaling in the pregestational intrauterine growth-restricted rat offspring.
Insulin Resistance
Protein phosphatases and podocyte function.
Insulin Resistance
PTEN down-regulation by unsaturated fatty acids triggers hepatic steatosis via an NF-kappaBp65/mTOR-dependent mechanism.
Insulin Resistance
PTEN expression and its association with glucose control and calorie supplementation in critically ill patients.
Insulin Resistance
PTEN in propofol-induced insulin resistance in mouse primary hepatocytes.
Insulin Resistance
PTEN influences insulin and lipid metabolism in bovine hepatocytes in vitro.
Insulin Resistance
Role of tumor suppressor PTEN in tumor necrosis factor alpha-induced inhibition of insulin signaling in murine skeletal muscle C2C12 cells.
Insulin Resistance
Sex differences in skeletal muscle phosphatase and tensin homolog deleted on chromosome 10 (PTEN) levels: a cross-sectional study.
Insulin Resistance
Silymarin induces insulin resistance through an increase of phosphatase and tensin homolog in Wistar rats.
Insulin Resistance
Synthesis of cytochrome c oxidase 1 (SCO1) inhibits insulin sensitivity by decreasing copper levels in adipocytes.
Insulin Resistance
The influence of diabetes in the pathogenesis and the clinical course of hepatocellular carcinoma: recent findings and new perspectives.
Insulin Resistance
Whole Transcriptome Analysis of Obese Adipose Tissue Suggests u001kfc.1 as a Potential Regulator to Glucose Homeostasis.
Insulinoma
Pancreatic endocrine tumors: expression profiling evidences a role for AKT-mTOR pathway.
Intellectual Disability
A role for nuclear PTEN in neuronal differentiation.
Intellectual Disability
Multicentric Glioma Develops via a Mutant IDH1-Independent Pathway: Immunohistochemical Study of Multicentric Glioma.
Intestinal Polyposis
Hamartomatous polyposis syndromes.
Intracranial Aneurysm
Dysregulation of microRNA?23b?3p contributes to the development of intracranial aneurysms by targeting phosphatase and tensin homolog.
Intracranial Aneurysm
Mesenchymal stem cells-derived exosomes modulate vascular endothelial injury via miR-144-5p/PTEN in intracranial aneurysm.
Ischemic Stroke
Inhibition of phosphatase and tensin homolog deleted on chromosome 10 decreases rat cortical neuron injury and blood-brain barrier permeability, and improves neurological functional recovery in traumatic brain injury model.
Ischemic Stroke
Preservation of GABAA receptor function by PTEN inhibition protects against neuronal death in ischemic stroke.
Ischemic Stroke
PTEN degradation after ischemic stroke: a double-edged sword.
Keloid
Wubeizi Ointment Suppresses Keloid Formation through Modulation of the mTOR Pathway.
Kidney Neoplasms
Identification of PTEN/MMAC1 alterations in uncultured melanomas and melanoma cell lines.
Kidney Neoplasms
The diverse roles of SPOP in prostate cancer and kidney cancer.
Klippel-Trenaunay-Weber Syndrome
Congenital Limb Overgrowth Syndromes Associated with Vascular Anomalies.
Laryngeal Neoplasms
DJ-1-induced phosphatase and tensin homologue downregulation is associated with proliferative and invasive activity of laryngeal cancer cells.
Leiomyoma
Changes related to phosphatidylinositol 3-kinase/Akt signaling in leiomyomas: possible involvement of glycogen synthase kinase 3alpha and cyclin D2 in the pathophysiology.
Leiomyoma
Expression of proliferative and preapoptotic molecules in human myometrium and leiomyoma throughout the menstrual cycle.
Leiomyosarcoma
PTEN/MMAC1 gene mutation is a rare event in soft tissue sarcomas without specific balanced translocations.
Leiomyosarcoma
The Akt/mammalian target of rapamycin pathway is activated and associated with adverse prognosis in soft tissue leiomyosarcomas.
Leukemia
Combined Casein Kinase II inhibition and epigenetic modulation in acute B-lymphoblastic leukemia.
Leukemia
Constitutively active AKT depletes hematopoietic stem cells and induces leukemia in mice.
Leukemia
DNA damage response as a prognostic indicator in metastatic breast cancer via mutational analysis.
Leukemia
Fit ?? T-Cell Receptor suppresses leukemogenesis of Pten-deficient thymocytes.
Leukemia
Imatinib causes epigenetic alterations of PTEN gene via upregulation of DNA methyltransferases and polycomb group proteins.
Leukemia
Mutation analysis of PTEN/MMAC1 in acute myeloid leukemia.
Leukemia
Pivotal role of Pten in the balance between proliferation and differentiation of hematopoietic stem cells in zebrafish.
Leukemia
Rictor/mammalian target of rapamycin 2 regulates the development of Notch1 induced murine T-cell acute lymphoblastic leukemia via forkhead box O3.
Leukemia
Suppression of leukemia development caused by PTEN loss.
Leukemia
[The role of PTEN-FAK signaling pathway in metastasis and invasive ability of leukemia cells]
Leukemia, Lymphocytic, Chronic, B-Cell
Low expression level of phosphatase and tensin homolog deleted on chromosome ten predicts poor prognosis in chronic lymphocytic leukemia.
Leukemia, Lymphocytic, Chronic, B-Cell
The phosphoinositide 3-kinase pathway in chronic lymphocytic leukemia: evidence for phosphatase and tensin homolog deletion on chromosome 10 deregulation.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
BCR-ABL translocation in a dog with chronic monocytic leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Depleting long noncoding RNA HOTAIR attenuates chronic myelocytic leukemia progression by binding to DNA methyltransferase 1 and inhibiting PTEN gene promoter methylation.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
[The role of PTEN-FAK signaling pathway in metastasis and invasive ability of leukemia cells]
Leukemia, Myeloid, Acute
Elevated S-phase kinase-associated protein 2 protein expression in acute myelogenous leukemia: its association with constitutive phosphorylation of phosphatase and tensin homologue protein and poor prognosis.
Leukemia, Myeloid, Acute
Mutation analysis of PTEN/MMAC1 in acute myeloid leukemia.
Leukemia, Myeloid, Acute
Prognostic value of the expression of phosphatase and tensin homolog and CD44 in elderly patients with refractory acute myeloid leukemia.
Leukemia, Myeloid, Acute
[Expression and Significance of PTEN and BCL-2 in Acute Myeloid Leukemia].
Leukemia-Lymphoma, Adult T-Cell
Pathophysiological significance of N-myc downstream-regulated gene 2 in cancer development through protein phosphatase 2A phosphorylation regulation.
Lipoma
A new human adipocyte model with PTEN haploinsufficiency.
Lipoma
Simvastatin induces apoptosis in PTEN?haploinsufficient lipoma cells.
Lipomatosis
Resveratrol Potentiates Growth Inhibitory Effects of Rapamycin in PTEN-deficient Lipoma Cells by Suppressing p70S6 Kinase Activity.
Liposarcoma
Juvenile Granulosa Cell Tumor of the Ovary: A Clinicopathologic Study.
Liver Cirrhosis
Curcumin up-regulates phosphatase and tensin homologue deleted on chromosome 10 through microRNA-mediated control of DNA methylation--a novel mechanism suppressing liver fibrosis.
Liver Cirrhosis
miR-21-regulated M2 polarization of macrophage is involved in arsenicosis-induced hepatic fibrosis through the activation of hepatic stellate cells.
Liver Cirrhosis
Non-alcoholic steatohepatitis and hepatocellular carcinoma: lessons from hepatocyte-specific phosphatase and tensin homolog (PTEN)-deficient mice.
Liver Diseases
Identification of microRNAs specifically expressed in hepatitis C virus-associated hepatocellular carcinoma.
Liver Diseases
Phosphatase and tensin homolog is a differential diagnostic marker between nonalcoholic and alcoholic fatty liver disease.
Liver Diseases
The ménage à trois of autophagy, lipid droplets and liver disease.
Liver Diseases, Alcoholic
New liver cancer biomarkers: PI3K/AKT/mTOR pathway members and eukaryotic translation initiation factors.
Liver Neoplasms
A phosphorylation switch controls the spatiotemporal activation of Rho GTPases in directional cell migration.
Liver Neoplasms
Association of PTEN expression with liver function and inflammatory changes in patients with liver cancer after chemotherapy.
Liver Neoplasms
Association of PTEN gene polymorphisms with liver cancer risk.
Liver Neoplasms
Effect of overexpression of PTEN on apoptosis of liver cancer cells.
Liver Neoplasms
Hippo-mediated suppression of IRS2/AKT signaling prevents hepatic steatosis and liver cancer.
Liver Neoplasms
Oncogenic Activity of Solute Carrier Family 45 Member 2 and Alpha-Methylacyl-Coenzyme A Racemase Gene Fusion Is Mediated by Mitogen-Activated Protein Kinase.
Liver Neoplasms
Overexpression of microRNA-30a-5p inhibits liver cancer cell proliferation and induces apoptosis by targeting MTDH/PTEN/AKT pathway.
Liver Neoplasms
Sequencing the full-length of the phosphatase and tensin homolog (PTEN) gene in hepatocellular carcinoma (HCC) using the 454 GS20 and Illumina GA DNA sequencing platforms.
Liver Neoplasms
Suppression of miR-21 Expression Inhibits Cell Proliferation and Migration of Liver Cancer Cells by Targeting Phosphatase and Tensin Homolog (PTEN).
Long QT Syndrome
Oxidative inactivation of the lipid phosphatase phosphatase and tensin homolog on chromosome ten (PTEN) as a novel mechanism of acquired long QT syndrome.
Lung Neoplasms
Alteration of the PTEN/MMAC1 gene locus in primary lung cancer with distant metastasis.
Lung Neoplasms
Alterations of PTEN/MMAC1, a candidate tumor suppressor gene, and its homologue, PTH2, in small cell lung cancer cell lines.
Lung Neoplasms
Analysis of PTEN/MMAC1 alterations in aerodigestive tract tumors.
Lung Neoplasms
Circular RNA circ-PTEN elevates PTEN inhibiting the proliferation of non-small cell lung cancer cells.
Lung Neoplasms
Circular RNA circ_0001287 inhibits the proliferation, metastasis, and radiosensitivity of non-small cell lung cancer cells by sponging microRNA miR-21 and up-regulating phosphatase and tensin homolog expression.
Lung Neoplasms
Combination of PTEN and gamma-ionizing radiation enhances cell death and G(2)/M arrest through regulation of AKT activity and p21 induction in non-small-cell lung cancer cells.
Lung Neoplasms
Concurrent epidermal growth factor receptor T790M secondary mutation and epithelial-mesenchymal transition in a lung adenocarcinoma patient with EGFR-TKI drug resistance.
Lung Neoplasms
DNA synthesis and repair genes RRM1 and ERCC1 in lung cancer.
Lung Neoplasms
Downregulation of PTEN mediates bleomycin-induced premature senescence in lung cancer cells by suppressing autophagy.
Lung Neoplasms
EYA2 promotes lung cancer cell proliferation by downregulating the expression of PTEN.
Lung Neoplasms
High levels of phosphatase and tensin homolog expression predict favorable prognosis in patients with non-small cell lung cancer.
Lung Neoplasms
High levels of Phosphatase and Tensin Homolog Expression Predict Favorable Prognosis in Patients with Non-small Cell Lung Cancer.
Lung Neoplasms
Hypoxia-induced modulation of PTEN activity and EMT phenotypes in lung cancers.
Lung Neoplasms
Increased tissue factor expression is associated with reduced survival in non-small cell lung cancer and with mutations of TP53 and PTEN.
Lung Neoplasms
Loss of phosphatase and tensin homolog expression correlates with clinicopathological features of non-small cell lung cancer patients and its impact on survival: A systematic review and meta-analysis.
Lung Neoplasms
MicroRNA-4286 promotes cell proliferation, migration, and invasion via PTEN regulation of the PI3K/Akt pathway in non-small cell lung cancer.
Lung Neoplasms
miR-1297 Promotes Cell Proliferation of Non-Small Cell Lung Cancer Cells: Involving in PTEN/Akt/Skp2 Signaling Pathway.
Lung Neoplasms
miR-543 is up-regulated in gefitinib-resistant non-small cell lung cancer and promotes cell proliferation and invasion via phosphatase and tensin homolog.
Lung Neoplasms
mTOR inhibitors radiosensitize PTEN-deficient non-small-cell lung cancer cells harboring an EGFR activating mutation by inducing autophagy.
Lung Neoplasms
Mutation analysis of the PTEN/MMAC1 gene in lung cancer.
Lung Neoplasms
Optimization of patient selection for gefitinib in non-small cell lung cancer by combined analysis of epidermal growth factor receptor mutation, K-ras mutation, and Akt phosphorylation.
Lung Neoplasms
Phosphatase and tensin homolog deleted on chromosome 10 degradation induced by NEDD4 promotes acquired erlotinib resistance in non-small-cell lung cancer.
Lung Neoplasms
Phosphatase and tensin homolog protein may be linked to lymph node metastasis and tumor node metastasis staging in nonsmall cell lung cancer.
Lung Neoplasms
PTEN expression is a prognostic marker for patients with non-small cell lung cancer: a systematic review and meta-analysis of the literature.
Lung Neoplasms
PTEN expression is associated with the outcome of lung cancer: evidence from a meta-analysis.
Lung Neoplasms
Pten inactivation accelerates oncogenic K-ras-initiated tumorigenesis in a mouse model of lung cancer.
Lung Neoplasms
PTEN mutations and relationship to EGFR, ERBB2, KRAS, and TP53 mutations in non-small cell lung cancers.
Lung Neoplasms
PTEN plays an important role in thrombin-mediated lung cancer cell functions.
Lung Neoplasms
PTEN/MMAC1 mutations identified in small cell, but not in non-small cell lung cancers.
Lung Neoplasms
SHCBP1 regulates apoptosis in lung cancer cells through phosphatase and tensin homolog.
Lung Neoplasms
Small activating ribonucleic acid reverses tyrosine kinase inhibitor resistance in epidermal growth factor receptor-mutant lung cancer by increasing the expression of phosphatase and tensin homolog.
Lung Neoplasms
Suberoylanilide hydroxamic acid overcomes erlotinib-acquired resistance via phosphatase and tensin homolog deleted on chromosome 10-mediated apoptosis in non-small cell lung cancer.
Lung Neoplasms
The deubiquitinase USP10 restores PTEN activity and inhibits non-small cell lung cancer cell proliferation.
Lung Neoplasms
The influence of circular RNAs on autophagy and disease progression.
Lung Neoplasms
The ISG15-specific protease USP18 regulates stability of PTEN.
Lung Neoplasms
The long non?coding RNA CASC7 inhibits growth and invasion of non?small cell lung cancer cells through phosphatase and tensin homolog upregulation via sequestration of miR?92a.
Lung Neoplasms
Upregulation of Neural Precursor Cell Expressed Developmentally Downregulated 4-1 is Associated with Poor Prognosis and Chemoresistance in Lung Adenocarcinoma.
Lung Neoplasms
[Expression of Gemcitabine-resistance-related gene and polymorphism of ribonucleotide reductase M1 gene promoter in Gemcitabine-resistant A549/Gem and NCI-H460/Gem cell lines]
Lupus Erythematosus, Systemic
Systemic lupus erythematosus in a girl with PTEN variant and transaldolase deficiency: a novel phenotype.
Lymphatic Metastasis
Expression of ribonucleotide reductase M2 subunit in gastric cancer and effects of RRM2 inhibition in vitro.
Lymphatic Metastasis
Loss of PTEN is associated with elevated EGFR and HER2 expression and worse prognosis in salivary gland cancer.
Lymphatic Metastasis
MiR-132 promotes the proliferation, invasion and migration of human pancreatic carcinoma by inhibition of the tumor suppressor gene PTEN.
Lymphatic Metastasis
Molecular determinants for lymph node metastasis in clinically early-stage endometrial cancer.
Lymphatic Metastasis
Phosphatase and tensin homolog protein may be linked to lymph node metastasis and tumor node metastasis staging in nonsmall cell lung cancer.
Lymphatic Metastasis
The Expression and Prognostic Impact of the PI3K/AKT/mTOR Signaling Pathway in Advanced Esophageal Squamous Cell Carcinoma.
Lymphatic Metastasis
The phosphatase and tensin homologue deleted on chromosome 10 mediates radiosensitivity in head and neck cancer.
Lymphoma
Analysis of the expression level and methylation of tumor protein p53, phosphatase and tensin homolog and mutS homolog 2 in N-methyl-N-nitrosourea-induced thymic lymphoma in C57BL/6 mice.
Lymphoma
Deletions in the long arm of chromosome 10 in lymphomas with t(14;18): a pathogenetic role of the tumor supressor genes PTEN/MMAC1 and MXI1?
Lymphoma
Evaluation of the PIK3 pathway in peripheral T-cell lymphoma and NK/T-cell lymphoma.
Lymphoma
Knockdown of NUPR1 inhibits the growth of U266 and RPMI8226 multiple myeloma cell lines via activating PTEN and caspase activation?dependent apoptosis.
Lymphoma
MCL1 Gene Silencing Promotes Senescence and Apoptosis of Glioma Cells via Inhibition of the PI3K/Akt Signaling Pathway.
Lymphoma
MicroRNA?27a promotes tumorigenesis via targeting AKT in triple negative breast cancer.
Lymphoma
Phosphatase and tensin homolog (PTEN) is down-regulated in human NK/T-cell lymphoma and corrects with clinical outcomes.
Lymphoma
Role of miR-21 in the growth and metastasis of human salivary adenoid cystic carcinoma.
Lymphoma
The antidepressant sertraline inhibits translation initiation by curtailing mammalian target of rapamycin signaling.
Lymphoma
Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model.
Lymphoma
Tripartite motif?containing 11 regulates the proliferation and apoptosis of breast cancer cells.
Lymphoma
Upregulation of phosphatase and tensin homolog is essential for the effect of 4-aminopyridine on A549/CDDP cells.
Lymphoma
[Anti-sense miRNA-21 oligonucleotide inhibits Tb 3.1 human tongue squamous cell carcinoma growth in vitro.]
Lymphoma, B-Cell
Clinical, morphological and immunohistochemical survey in different types of endometriosis.
Lymphoma, B-Cell
Cytotoxic effects of hydroalcoholic extract of Cuscuta chinensis on PC3 and MCF7 cancer cell lines.
Lymphoma, B-Cell
Effect of TIEG1 on apoptosis and expression of Bcl-2/Bax and Pten in leukemic cell lines.
Lymphoma, B-Cell
MCL1 Gene Silencing Promotes Senescence and Apoptosis of Glioma Cells via Inhibition of the PI3K/Akt Signaling Pathway.
Lymphoma, B-Cell
MicroRNA-146b induces the PI3K/Akt/NF-?B signaling pathway to reduce vascular inflammation and apoptosis in myocardial infarction by targeting PTEN.
Lymphoma, B-Cell
microRNA-22 attenuates neuronal cell apoptosis in a cell model of traumatic brain injury.
Lymphoma, B-Cell
MicroRNA-related transcription factor regulatory networks in human colorectal cancer.
Lymphoma, B-Cell
MicroRNA?27a promotes tumorigenesis via targeting AKT in triple negative breast cancer.
Lymphoma, B-Cell
miRNA-29a inhibits colon cancer growth by regulation of the PTEN/Akt/GSK3? and Wnt/?-catenin signaling pathways.
Lymphoma, B-Cell
mTOR activity in AIDS-related diffuse large B-cell lymphoma.
Lymphoma, B-Cell
Pathogenicity and virulence of Japanese encephalitis virus: Neuroinflammation and neuronal cell damage.
Lymphoma, B-Cell
Prediction of Relapse After Therapy Withdrawal in Women with Endometrial Hyperplasia: A Long-term Follow-up Study.
Lymphoma, B-Cell
Predictive biomarkers for combined chemotherapy with 5-fluorouracil and cisplatin in oro- and hypopharyngeal cancers.
Lymphoma, B-Cell
Preventive Effect of Lactobacillus fermentum CQPC08 on 4-Nitroquineline-1-Oxide Induced Tongue Cancer in C57BL/6 Mice.
Lymphoma, B-Cell
The expression of microRNAs and exposure to environmental contaminants related to human health: a review.
Lymphoma, B-Cell
[Anti-sense miRNA-21 oligonucleotide inhibits Tb 3.1 human tongue squamous cell carcinoma growth in vitro.]
Lymphoma, B-Cell
[The expression and meanning of Skp2, p27, PTEN proteins in non-Hodgkin B-cell lymphoma of ocular adnexa].
Lymphoma, Large B-Cell, Diffuse
mTOR activity in AIDS-related diffuse large B-cell lymphoma.
Lymphoma, Non-Hodgkin
Mutational analysis of the PTEN/MMAC1 gene in non-Hodgkin's lymphoma.
Lymphoma, Non-Hodgkin
[Expression of PTEN and p27 proteins in non-Hodgkin's lymphoma]
Malaria
Overexpression of phosphatase and tensin homolog improves fitness and decreases Plasmodium falciparum development in Anopheles stephensi.
Malformations of Cortical Development
Lhermitte-Duclos disease with neurofibrillary tangles in heterotopic cerebral grey matter.
Malformations of Cortical Development
Rapamycin prevents, but does not reverse, aberrant migration in Pten knockout neurons.
Medulloblastoma
PTEN loss mitigates the response of medulloblastoma to Hedgehog pathway inhibition.
Megalencephaly
A role for nuclear PTEN in neuronal differentiation.
Megalencephaly
Decreased aggression and increased repetitive behavior in Pten haploinsufficient mice.
Megalencephaly
Finding a better drug for epilepsy: the mTOR pathway as an antiepileptogenic target.
Megalencephaly
Macrocephaly as a clinical indicator of genetic subtypes in autism.
Megalencephaly
Multifocal demyelinating motor neuropathy and hamartoma syndrome associated with a de novo PTEN mutation.
Megalencephaly
Mutations in the sonic hedgehog pathway cause macrocephaly-associated conditions due to crosstalk to the PI3K/AKT/mTOR pathway.
Megalencephaly
Neurobehavioral phenotype of autism spectrum disorder associated with germline heterozygous mutations in PTEN.
Megalencephaly
Phosphatase and Tensin Homolog (PTEN) Gene Mutations and Autism: Literature Review and a Case Report of a Patient With Cowden Syndrome, Autistic Disorder and Epilepsy.
Megalencephaly
Prevalence and clinical/molecular characteristics of PTEN mutations in Turkish children with autism spectrum disorders and macrocephaly.
Megalencephaly
Rapamycin prevents, but does not reverse, aberrant migration in Pten knockout neurons.
Megalencephaly
Therapeutic inhibition of mTORC2 rescues the behavioral and neurophysiological abnormalities associated with Pten-deficiency.
Melanoma
A Rare Case of Atypical Pleomorphic Neoplasm of Pineal Region in a Child: A Case Report.
Melanoma
Comparative oncogenomics identifies tyrosine kinase FES as a tumor suppressor in melanoma.
Melanoma
Comprehensive Analysis of PTEN in Primary Cutaneous Melanoma.
Melanoma
E- to N-cadherin switch in melanoma is associated with decreased expression of phosphatase and tensin homolog and cancer progression.
Melanoma
Epigenetic silencing of the PTEN gene in melanoma.
Melanoma
Examination of mutations in BRAF, NRAS, and PTEN in primary cutaneous melanoma.
Melanoma
Expression of activated Akt and PTEN in malignant melanomas: relationship with clinical outcome.
Melanoma
Expression of HSP 90, PTEN and Bcl-2 in conjunctival melanoma.
Melanoma
Focal adhesion kinase: a promising target for anticancer therapy.
Melanoma
Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma.
Melanoma
Identification of PTEN/MMAC1 alterations in uncultured melanomas and melanoma cell lines.
Melanoma
Immunohistochemical analysis of T-type calcium channels in acquired melanocytic naevi and melanoma.
Melanoma
In vitro loss of heterozygosity targets the PTEN/MMAC1 gene in melanoma.
Melanoma
iNOS Associates With Poor Survival in Melanoma: A Role for Nitric Oxide in the PI3K-AKT Pathway Stimulation and PTEN S-Nitrosylation.
Melanoma
Loss of PTEN promotes tumor development in malignant melanoma.
Melanoma
Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis.
Melanoma
miR?367 enhances the proliferation and invasion of cutaneous malignant melanoma by regulating phosphatase and tensin homolog expression.
Melanoma
Mutation and allelic loss of the PTEN/MMAC1 gene in primary and metastatic melanoma biopsies.
Melanoma
Pleckstrin homology domain-interacting protein (PHIP) as a marker and mediator of melanoma metastasis.
Melanoma
PRL-3 Promotes the Malignant Progression of Melanoma via Triggering Dephosphorylation and Cytoplasmic Localization of NHERF1.
Melanoma
Promoter Methylation of PTEN Is a Significant Prognostic Factor in Melanoma Survival.
Melanoma
PTEN expression in melanoma: relationship with patient survival, Bcl-2 expression, and proliferation.
Melanoma
PTEN expression in normal skin, acquired melanocytic nevi, and cutaneous melanoma.
Melanoma
PTEN functions as a melanoma tumor suppressor by promoting host immune response.
Melanoma
PTEN regulates sensitivity of melanoma cells to RO4929097, the ?-secretase inhibitor.
Melanoma
PTEN signaling pathways in melanoma.
Melanoma
PTEN/MMAC1 expression in melanoma resection specimens.
Melanoma
PTEN/MMAC1 in malignant melanoma and its importance for tumor progression.
Melanoma
PTEN/MMAC1 mutations in hepatocellular carcinomas.
Melanoma
Recent advances in melanoma research.
Melanoma
Relative reciprocity of NRAS and PTEN/MMAC1 alterations in cutaneous melanoma cell lines.
Melanoma
Shank-associated RH domain interactor signaling in tumorigenesis.
Melanoma
Targeting human apurinic/apyrimidinic endonuclease 1 (APE1) in phosphatase and tensin homolog (PTEN) deficient melanoma cells for personalized therapy.
Melanoma
WNT/?-catenin signaling regulates mitochondrial activity to alter the oncogenic potential of melanoma in a PTEN-dependent manner.
Memory Disorders
Effect of adenovirus-mediated overexpression of PTEN on brain oxidative damage and neuroinflammation in a rat kindling model of epilepsy.
Meningioma
Low Expression of Phosphatase and Tensin Homolog and High Expression of Ki-67 as Risk Factors of Prognosis in Cranial Meningiomas.
Mesothelioma
Mutation analysis of the PTEN/MMAC1 gene in lung cancer.
Mesothelioma
Mutational analysis of the PTEN/MMAC1 tumour suppressor gene in primary human malignant mesotheliomas.
Mesothelioma, Malignant
Mutational analysis of the PTEN/MMAC1 tumour suppressor gene in primary human malignant mesotheliomas.
Metabolic Syndrome
Role and mechanism of PTEN in adiponectin-induced osteogenesis in human bone marrow mesenchymal stem cells.
Migraine Disorders
PI3K/AKT signaling pathway activation in a rat model of migraine.
Migraine Disorders
PTEN inhibition preserves trigeminal nucleus caudalis neuron activation through tyrosine phosphorylation of the NR2B subunit at Tyr1472 of the NMDA receptor in a rat model of recurrent migraine.
Mucocutaneous Lymph Node Syndrome
[Phosphatase and tensin homolog deleted on chromosome ten/phosphatidyl Inositol 3-kinase/vascular endothelial growth factor signaling pathway changes in the rabbit Kawasaki disease model].
Multiple Endocrine Neoplasia Type 2a
Diffuse intestinal ganglioneuromatosis an uncommon manifestation of Cowden syndrome.
Multiple Myeloma
Expression levels of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) and focal adhesion kinase in patients with multiple myeloma and their relationship to clinical stage and extramedullary infiltration.
Multiple Myeloma
Expression Patterns of Growth and Survival Genes with Prognostic Implications in Advanced Pancreatic Cancer.
Multiple Myeloma
The role of phosphatase and tensin homolog deleted on chromosome 10 and focal adhesion kinase in aggressive multiple myeloma.
Muscular Atrophy
Evidence for a role of immunoproteasomes in regulating cardiac muscle mass in diabetic mice.
Muscular Diseases
Myotubularin lipid phosphatase binds the hVPS15/hVPS34 lipid kinase complex on endosomes.
Muscular Dystrophies
Conditional Inactivation of Nf1 and Pten in Schwann Cells Results in Abnormal Neuromuscular Junction Maturation.
Muscular Dystrophy, Duchenne
Polymeric nanoparticles functionalized with muscle-homing peptides for targeted delivery of phosphatase and tensin homolog inhibitor to skeletal muscle.
Myeloproliferative Disorders
Rictor/mammalian target of rapamycin 2 regulates the development of Notch1 induced murine T-cell acute lymphoblastic leukemia via forkhead box O3.
Myocardial Infarction
Effects of mir-21 on Cardiac Microvascular Endothelial Cells After Acute Myocardial Infarction in Rats: Role of Phosphatase and Tensin Homolog (PTEN)/Vascular Endothelial Growth Factor (VEGF) Signal Pathway.
Myocardial Infarction
Loss of Phosphatase and Tensin Homolog Promotes Cardiomyocyte Proliferation and Cardiac Repair After Myocardial Infarction.
Myocardial Infarction
MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue.
Myocardial Infarction
MicroRNA-214 Inhibits Left Ventricular Remodeling in an Acute Myocardial Infarction Rat Model by Suppressing Cellular Apoptosis via the Phosphatase and Tensin Homolog (PTEN).
Myocardial Ischemia
(?)?Epicatechin protects against myocardial ischemia?induced cardiac injury via activation of the PTEN/PI3K/AKT pathway.
Myocardial Ischemia
Inhibition of TRPA1 Promotes Cardiac Repair in Mice After Myocardial Infarction.
Nasopharyngeal Carcinoma
Aberrant CpG island methylation of PTEN is an early event in nasopharyngeal carcinoma and a potential diagnostic biomarker.
Nasopharyngeal Carcinoma
Dynamic contrast-enhanced MRI predicts PTEN protein expression which can function as a prognostic measure of progression-free survival in NPC patients.
Nasopharyngeal Carcinoma
Inhibition of PTEN Gene Expression by Small Interfering RNA on PI3K/Akt/FoxO3a Signaling Pathway in Human Nasopharyngeal Carcinoma.
Nasopharyngeal Carcinoma
MicroRNA-152 Targets Phosphatase and Tensin Homolog to Inhibit Apoptosis and Promote Cell Migration of Nasopharyngeal Carcinoma Cells.
Nasopharyngeal Carcinoma
miR-144-3p facilitates nasopharyngeal carcinoma via crosstalk with PTEN.
Nasopharyngeal Carcinoma
[CD44 regulates biological behavior and Ras signaling pathway in nasopharyngeal carcinoma stem cells].
Nasopharyngeal Carcinoma
[Relationship between PTEN mutations and protein kinase B phosphorylation caused by insulin or recombinant human epidermal growth factor stimulation].
Neoplasm Metastasis
Alteration of the PTEN/MMAC1 gene locus in primary lung cancer with distant metastasis.
Neoplasm Metastasis
Circular RNA circ_0001287 inhibits the proliferation, metastasis, and radiosensitivity of non-small cell lung cancer cells by sponging microRNA miR-21 and up-regulating phosphatase and tensin homolog expression.
Neoplasm Metastasis
Down-regulated lncRNA TP73-AS1 reduces radioresistance in hepatocellular carcinoma via the PTEN/Akt signaling pathway.
Neoplasm Metastasis
Downregulation of STRAP promotes tumor growth and metastasis in hepatocellular carcinoma via reducing PTEN level.
Neoplasm Metastasis
Dp44mT targets the AKT, TGF-? and ERK pathways via the metastasis suppressor NDRG1 in normal prostate epithelial cells and prostate cancer cells.
Neoplasm Metastasis
Epithelial-myoepithelial carcinoma of the parotid gland-evidence of contrasting DNA patterns in two different histological parts.
Neoplasm Metastasis
Expression of ribonucleotide reductase M2 subunit in gastric cancer and effects of RRM2 inhibition in vitro.
Neoplasm Metastasis
Gene heterogeneity in metastasis of colorectal cancer to the lung.
Neoplasm Metastasis
Generation of PTEN?knockout (?/?) murine prostate cancer cells using the CRISPR/Cas9 system and comprehensive gene expression profiling.
Neoplasm Metastasis
Genetic alterations of the tumor suppressor gene PTEN/MMAC1 in human brain metastases.
Neoplasm Metastasis
Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma.
Neoplasm Metastasis
High levels of phosphatase and tensin homolog expression are associated with tumor progression, tumor recurrence, and systemic metastases in pT1 urothelial carcinoma of the bladder: a tissue microarray study of 156 patients treated by transurethral resection.
Neoplasm Metastasis
Identification of a Glycolysis-Related LncRNA Signature to Predict Survival in Diffuse Glioma Patients.
Neoplasm Metastasis
Immunohistochemical expression of mTOR negatively correlates with PTEN expression in gastric carcinoma.
Neoplasm Metastasis
Insights into the targeting potential of thymoquinone for therapeutic intervention against triple-negative breast cancer.
Neoplasm Metastasis
KRAS mutation in lung metastases from colorectal cancer: prognostic implications.
Neoplasm Metastasis
LncRNA GAS5 Suppresses the Proliferation and Invasion of Osteosarcoma Cells via the miR-23a-3p/PTEN/PI3K/AKT Pathway.
Neoplasm Metastasis
Long non?coding RNA FER1L4 inhibits cell proliferation and metastasis through regulation of the PI3K/AKT signaling pathway in lung cancer cells.
Neoplasm Metastasis
Loss of heterozygosity and mutational analysis of the PTEN/MMAC1 gene in synchronous endometrial and ovarian carcinomas.
Neoplasm Metastasis
Loss of phosphatase and tensin homolog enhances cell invasion and migration through AKT/Sp-1 transcription factor/matrix metalloproteinase 2 activation in hepatocellular carcinoma and has clinicopathologic significance.
Neoplasm Metastasis
Loss of PTEN is associated with elevated EGFR and HER2 expression and worse prognosis in salivary gland cancer.
Neoplasm Metastasis
Mesenchymal stem cell signaling in cancer progression.
Neoplasm Metastasis
MicroRNA 26b promotes colorectal cancer metastasis by downregulating phosphatase and tensin homolog and wingless-type MMTV integration site family member 5A.
Neoplasm Metastasis
microRNA-19a-3p promotes tumor metastasis and chemoresistance through the PTEN/Akt pathway in hepatocellular carcinoma.
Neoplasm Metastasis
MicroRNA-92a promotes epithelial-mesenchymal transition through activation of PTEN/PI3K/AKT signaling pathway in non-small cell lung cancer metastasis.
Neoplasm Metastasis
miR-10b expression in breast cancer stem cells supports self-renewal through negative PTEN regulation and sustained AKT activation.
Neoplasm Metastasis
MiR-132 promotes the proliferation, invasion and migration of human pancreatic carcinoma by inhibition of the tumor suppressor gene PTEN.
Neoplasm Metastasis
miR-298 plays a pivotal role in colon cancer invasiveness by targeting PTEN.
Neoplasm Metastasis
Molecular determinants for lymph node metastasis in clinically early-stage endometrial cancer.
Neoplasm Metastasis
Negative expression of PTEN identifies high risk for lymphatic-related metastasis in human esophageal squamous cell carcinoma.
Neoplasm Metastasis
Next-generation sequencing-based identification of EGFR and NOTCH2 complementary mutations in non-small cell lung cancer.
Neoplasm Metastasis
Overexpression of brachyury contributes to tumor metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma.
Neoplasm Metastasis
Overexpression of PTEN suppresses non-small-cell lung carcinoma metastasis through inhibition of integrin ?V?6 signaling.
Neoplasm Metastasis
Pancreatic endocrine tumors: expression profiling evidences a role for AKT-mTOR pathway.
Neoplasm Metastasis
Phosphatase and tensin homolog protein may be linked to lymph node metastasis and tumor node metastasis staging in nonsmall cell lung cancer.
Neoplasm Metastasis
PRL-3 promotes the peritoneal metastasis of gastric cancer through the PI3K/Akt signaling pathway by regulating PTEN.
Neoplasm Metastasis
PTEN inhibits the invasion and metastasis of gastric cancer via downregulation of FAK expression.
Neoplasm Metastasis
PTEN Insufficiency Increases Breast Cancer Cell Metastasis In Vitro and In Vivo in a Xenograft Zebrafish Model.
Neoplasm Metastasis
PTEN/MMAC1 in malignant melanoma and its importance for tumor progression.
Neoplasm Metastasis
PTP1B promotes aggressiveness of breast cancer cells by regulating PTEN but not EMT.
Neoplasm Metastasis
Relative reciprocity of NRAS and PTEN/MMAC1 alterations in cutaneous melanoma cell lines.
Neoplasm Metastasis
Small in Size, but Large in Action: microRNAs as Potential Modulators of PTEN in Breast and Lung Cancers.
Neoplasm Metastasis
Synergistic effects of Rapamycin and Fluorouracil to treat a gastric tumor in a PTEN conditional deletion mouse model.
Neoplasm Metastasis
The Expression and Prognostic Impact of the PI3K/AKT/mTOR Signaling Pathway in Advanced Esophageal Squamous Cell Carcinoma.
Neoplasm Metastasis
The phosphatase and tensin homologue deleted on chromosome 10 mediates radiosensitivity in head and neck cancer.
Neoplasm Metastasis
The role of PTEN in prostate cancer cell tropism to the bone micro-environment.
Neoplasm Metastasis
The tyrosine kinase inhibitors effects on metastatic tumor graft in the chick chorioallantoic membrane assay.
Neoplasm Metastasis
[The role of PTEN-FAK signaling pathway in metastasis and invasive ability of leukemia cells]
Neoplasms
(?)?Epigallocatechin?3?gallate induces apoptosis in human pancreatic cancer cells via PTEN.
Neoplasms
10q23.3 loss of heterozygosity is higher in lymph node-positive (pT2-3,N+) versus lymph node-negative (pT2-3,N0) prostate cancer.
Neoplasms
3' Phosphatase activity toward phosphatidylinositol 3,4-bisphosphate [PI(3,4)P2] by voltage-sensing phosphatase (VSP).
Neoplasms
A case of Cowden syndrome diagnosed from multiple gastric polyposis.
Neoplasms
A case of follicular thyroid carcinoma associated with phosphatase and tensin homologue hamartoma tumour syndrome.
Neoplasms
A clinical study on the expression of PTEN in renal cell carcinoma in children.
Neoplasms
A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast.
Neoplasms
A glutamate switch controls voltage-sensitive phosphatase function.
Neoplasms
A heterozygous frameshift mutation of the PTEN/MMAC1 gene in a patient with Lhermitte-Duclos disease - only the mutated allele was expressed in the cerebellar tumor.
Neoplasms
A heterozygous germline mutation of the PTEN/MMAC1 gene in a patient with Cowden disease.
Neoplasms
A longitudinally extensive myelopathy associated with multiple spinal arteriovenous fistulas in a patient with Cowden syndrome: a case report.
Neoplasms
A miR-335/COX-2/PTEN axis regulates the secretory phenotype of senescent cancer-associated fibroblasts.
Neoplasms
A multicenter study shows PTEN deletion is strongly associated with seminal vesicle involvement and extracapsular extension in localized prostate cancer.
Neoplasms
A multicenter, single-arm, open-label, phase 2 study of apitolisib (GDC-0980) for the treatment of recurrent or persistent endometrial carcinoma (MAGGIE study).
Neoplasms
A mutant form of PTEN linked to autism.
Neoplasms
A neuroprotective phase precedes striatal degeneration upon nucleolar stress.
Neoplasms
A new class of cancer-associated PTEN mutations defined by membrane translocation defects.
Neoplasms
A new role for PTEN in regulating transient receptor potential canonical channel 6-mediated Ca2+ entry, endothelial permeability, and angiogenesis.
Neoplasms
A novel functional interplay between Progesterone Receptor-B and PTEN, via AKT, modulates autophagy in breast cancer cells.
Neoplasms
A novel missense PTEN mutation identified in a patient with macrocephaly and developmental delay.
Neoplasms
A novel model to identify interaction partners of the PTEN tumor suppressor gene in human bladder cancer.
Neoplasms
A novel mutation of the PTEN gene in a Japanese patient with Cowden syndrome and bilateral breast cancer.
Neoplasms
A novel phosphatidylinositol(3,4,5)P3 pathway in fission yeast.
Neoplasms
A Novel PTEN-Dependent Link to Ubiquitination Controls FLIPS Stability and TRAIL Sensitivity in Glioblastoma Multiforme.
Neoplasms
A novel PTEN/mutant p53/c-Myc/Bcl-XL axis mediates context-dependent oncogenic effects of PTEN with implications for cancer prognosis and therapy.
Neoplasms
A novel quantitative method of pten expression assessment in tumor tissue.
Neoplasms
A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis.
Neoplasms
A Pediatric Case of Cowden Syndrome with Graves' Disease.
Neoplasms
A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN.
Neoplasms
A PTEN inhibitor displays preclinical activity against hepatocarcinoma cells.
Neoplasms
A Rare Case of Atypical Pleomorphic Neoplasm of Pineal Region in a Child: A Case Report.
Neoplasms
A Saturation Mutagenesis Approach to Understanding PTEN Lipid Phosphatase Activity and Genotype-Phenotype Relationships.
Neoplasms
A secreted PTEN phosphatase that enters cells to alter signaling and survival.
Neoplasms
A short N-terminal sequence of PTEN controls cytoplasmic localization and is required for suppression of cell growth.
Neoplasms
A Soft Coral-Derived Compound, 11-Dehydrosinulariolide, Induces G2/M Cell Cycle Arrest and Apoptosis in Small Cell Lung Cancer.
Neoplasms
A Survey of Molecular Heterogeneity in Hepatocellular Carcinoma.
Neoplasms
A testis-specific gene, TPTE, encodes a putative transmembrane tyrosine phosphatase and maps to the pericentromeric region of human chromosomes 21 and 13, and to chromosomes 15, 22, and Y.
Neoplasms
A versatile modular vector system for rapid combinatorial mammalian genetics.
Neoplasms
Aberrant CpG island methylation of PTEN is an early event in nasopharyngeal carcinoma and a potential diagnostic biomarker.
Neoplasms
Aberrant PTEN, PIK3CA, pMAPK, and TP53 expression in human scalp and face angiosarcoma.
Neoplasms
Aberrant transcripts of FHIT, TSG101 and PTEN/MMAC1 genes in normal peripheral mononuclear cells.
Neoplasms
Abnormal structure and expression of PTEN/MMAC1 gene in human uterine cancers.
Neoplasms
Absence of PTEN/MMAC1 gene mutations in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats.
Neoplasms
ABT-737 and pictilisib synergistically enhance pitavastatin-induced apoptosis in ovarian cancer cells.
Neoplasms
Accelerated decline of blood glucose after intravenous glucose injection in a patient with Cowden disease having a heterozygous germline mutation of the PTEN/MMAC1 gene.
Neoplasms
Acid sphingomyelinase and inhibition by phosphate ion: role of inhibition by phosphatidyl-myo-inositol 3,4,5-triphosphate in oligodendrocyte cell signaling.
Neoplasms
Action of HMGB1 on miR-221/222 cluster in neuroblastoma cell lines.
Neoplasms
Activation of phosphatidylinositol 3-kinase/akt signaling pathway mediates acquired resistance to sorafenib in hepatocellular carcinoma cells.
Neoplasms
Activation of the mTOR pathway by low levels of xenoestrogens in breast epithelial cells from high-risk women.
Neoplasms
Activation of the oncogenic miR-21-5p promotes HCV replication and steatosis induced by the viral core 3a protein.
Neoplasms
Activation of the phosphatidylinositol 3'-kinase/AKT pathway in neuroblastoma and its regulation by thioredoxin 1.
Neoplasms
Activation of Toll?like receptor 7 regulates the expression of IFN??1, p53, PTEN, VEGF, TIMP?1 and MMP?9 in pancreatic cancer cells.
Neoplasms
Activation of tumor suppressor protein PTEN and induction of apoptosis are involved in cAMP-mediated inhibition of cell number in B92 glial cells.
Neoplasms
Acute T-cell leukemias remain dependent on Notch signaling despite PTEN and INK4A/ARF loss.
Neoplasms
Additive Effect of Zfhx3/Atbf1 and Pten Deletion on Mouse Prostatic Tumorigenesis.
Neoplasms
Adenoviral-mediated expression of a kinase-dead mutant of Akt induces apoptosis selectively in tumor cells and suppresses tumor growth in mice.
Neoplasms
Adenovirus-mediated co-expression of ING4 and PTEN cooperatively enhances their antitumor activity in human hepatocellular carcinoma cells.
Neoplasms
Adenovirus-mediated PTEN treatment combined with caffeine produces a synergistic therapeutic effect in colorectal cancer cells.
Neoplasms
Adipocyte enhancer-binding protein 1 modulates adiposity and energy homeostasis.
Neoplasms
Adiponectin haploinsufficiency promotes mammary tumor development in MMTV-PyVT mice by modulation of phosphatase and tensin homolog activities.
Neoplasms
Adipose PTEN regulates adult adipose tissue homeostasis and redistribution via a PTEN-leptin-sympathetic loop.
Neoplasms
Aerosol delivery of glucosylated polyethylenimine/phosphatase and tensin homologue deleted on chromosome 10 complex suppresses Akt downstream pathways in the lung of K-ras null mice.
Neoplasms
AIF inhibits tumor metastasis by protecting PTEN from oxidation.
Neoplasms
Air pollution-induced placental epigenetic alterations in early life: a candidate miRNA approach.
Neoplasms
Akt activation by arachidonic acid metabolism occurs via oxidation and inactivation of PTEN tumor suppressor.
Neoplasms
AKT activation promotes PTEN hamartoma tumor syndrome-associated cataract development.
Neoplasms
AKT and PTEN expression in human gastrointestinal carcinoid tumors.
Neoplasms
Akt-dependent proapoptotic effects of dietary restriction on late-stage management of a phosphatase and tensin homologue/tuberous sclerosis complex 2-deficient mouse astrocytoma.
Neoplasms
All-in-One inducible lentiviral vector systems based on drug controlled FLP recombinase.
Neoplasms
Allelic loss at 10q23.3 but lack of mutation of PTEN/MMAC1 in chromophobe renal cell carcinoma.
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Allopregnanolone Reverses Bioenergetic Deficits in Female Triple Transgenic Alzheimer's Mouse Model.
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Allosteric activation of PTEN phosphatase by phosphatidylinositol 4,5-bisphosphate.
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Alteration and clinical relevance of PTEN expression and its correlation with survivin expression in epithelial ovarian tumors.
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Alteration of the PTEN/MMAC1 gene locus in primary lung cancer with distant metastasis.
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Alterations of PTEN/MMAC1, a candidate tumor suppressor gene, and its homologue, PTH2, in small cell lung cancer cell lines.
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Alterations of the PPP1R3 gene in human cancer.
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Altered Expression of PTEN and Its Major Regulator MicroRNA-21 in Pulmonary Neuroendocrine Tumors.
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Altered PTEN function caused by deletion or gene disruption is associated with poor prognosis in rectal but not in colon cancer.
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Alternative pathways to prostate carcinoma activate prostate stem cell antigen expression.
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Alternative polyadenylation confers Pten mRNAs stability and resistance to microRNAs.
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An important role of SREBP-1 in HBV and HCV co-replication inhibition by PTEN.
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An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice.
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Analysis of phosphatase and tensin homolog tumor suppressor interacting proteins by in vitro and in silico proteomics.
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Analysis of PTEN ubiquitylation and SUMOylation using molecular traps.
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Analysis of PTEN/MMAC1 alteration in neuroblastoma.
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Analysis of PTEN/MMAC1 alterations in aerodigestive tract tumors.
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Analysis of the expression level and methylation of tumor protein p53, phosphatase and tensin homolog and mutS homolog 2 in N-methyl-N-nitrosourea-induced thymic lymphoma in C57BL/6 mice.
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Androgen actions via androgen receptor promote PTEN inactivation induced uterine cancer.
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Androgen-independent prostate cancer cells circumvent EGFR inhibition by overexpression of alternative HER receptors and ligands.
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Androgen-induced programs for prostate epithelial growth and invasion arise in embryogenesis and are reactivated in cancer.
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Antagonist of thromboxane A2 receptor by SQ29548 lowers DOCA-induced hypertension in diabetic rats.
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Anticancer Activities of Thymus vulgaris L. in Experimental Breast Carcinoma in Vivo and in Vitro.
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Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma.
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Antitumorigenic effects of peroxisome proliferator-activated receptor-gamma in non-small-cell lung cancer cells are mediated by suppression of cyclooxygenase-2 via inhibition of nuclear factor-kappaB.
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Approaches to Investigating the Protein Interactome of PTEN.
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Are aberrant transcripts of FHIT, TSG101, and PTEN/MMAC1 oncogenesis related?
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Assessment of epigenetic alterations and in silico analysis of mutation affecting PTEN expression among Indian cervical cancer patients.
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Association between PTEN Gene IVS4 polymorphism and risk of cancer: a meta-analysis.
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Association between PTEN IVS4 polymorphism and development of colorectal cancer in a Turkish population.
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Association of increased phosphatidylinositol 3-kinase signaling with increased invasiveness and gelatinase activity in malignant gliomas.
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Association of PTEN expression with liver function and inflammatory changes in patients with liver cancer after chemotherapy.
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Association of Single-Nucleotide Polymorphisms in Monoubiquitinated FANCD2-DNA Damage Repair Pathway Genes With Breast Cancer in the Chinese Population.
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ATM Regulated PTEN Degradation Is XIAP E3 Ubiquitin Ligase Mediated in p85? Deficient Cancer Cells and Influence Platinum Sensitivity.
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Autophagy drives fibroblast senescence through MTORC2 regulation.
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Autophagy in the physiological endometrium and cancer.
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Autophagy-dependent cancer cells circumvent loss of the upstream regulator RB1CC1/FIP200 and loss of LC3 conjugation by similar mechanisms.
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Autosomal Dominant Inherited Cowden's Disease in a Family.
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Balancing Proliferation and Connectivity in PTEN-associated Autism Spectrum Disorder.
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Bannayan-Riley-Ruvalcaba Syndrome in a Patient with a PTEN Mutation Identified by Chromosomal Microarray Analysis: A Case Report.
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BCR-ABL disrupts PTEN nuclear-cytoplasmic shuttling through phosphorylation-dependent activation of HAUSP.
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beta-Catenin activation synergizes with PTEN loss to cause bladder cancer formation.
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Beyond Trophic Factors: Exploiting the Intrinsic Regenerative Properties of Adult Neurons.
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Bioinformatics prediction of miR-30a targets and its inhibition of cell proliferation of osteosarcoma by up-regulating the expression of PTEN.
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Biomarkers That Predict Sensitivity to Heat Shock Protein 90 Inhibitors.
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Bisperoxovanadium compounds are potent PTEN inhibitors.
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Blockade of reactive oxygen species and Akt activation is critical for anti-inflammation and growth inhibition of metformin in phosphatase and tensin homolog-deficient RAW264.7 cells.
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Blocked autophagy using lysosomotropic agents sensitizes resistant prostate tumor cells to the novel Akt inhibitor AZD5363.
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BRCA1 Protein Expression Predicts Survival in Glioblastoma Patients from an NRG Oncology RTOG Cohort.
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Breast Cancer and Non-Hodgkin Lymphoma in a Young Male with Cowden Syndrome.
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Brothers with germline PTEN mutations and persistent hypoglycemia, macrocephaly, developmental delay, short stature, and coagulopathy.
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Caffeic Acid phenethyl ester as a potential treatment for advanced prostate cancer targeting akt signaling.
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Caffeic acid phenethyl ester as an adjuvant therapy for advanced prostate cancer.
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Caffeine activates tumor suppressor PTEN in sarcoma cells.
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Caffeine induces apoptosis of osteosarcoma cells by inhibiting AKT/mTOR/S6K, NF-?B and MAPK pathways.
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Calcitonin receptor expression in medullary thyroid carcinoma.
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Calcium-Sensing Receptor Tumor Expression and Lethal Prostate Cancer Progression.
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Cancer cell-oriented migration of mesenchymal stem cells engineered with an anticancer gene (PTEN): an imaging demonstration.
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Cancer gene panel analysis of cultured circulating tumor cells and primary tumor tissue from patients with breast cancer.
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Cancer phenomics: RET and PTEN as illustrative models.
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Catalysis by the tumor-suppressor enzymes PTEN and PTEN-L.
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CCND1- and ERBB2-gene deregulation and PTEN mutation analyses in invasive lobular carcinoma of the breast.
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CD10 expression in the neuroendocrine carcinoma component of endometrial mixed carcinoma: association with long survival.
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CDX2 inhibits invasion and migration of gastric cancer cells by phosphatase and tensin homologue deleted from chromosome 10/Akt signaling pathway.
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Cell Cycle Control by PTEN.
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Cell cycle-dependent nuclear export of phosphatase and tensin homologue tumor suppressor is regulated by the phosphoinositide-3-kinase signaling cascade.
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CFTR-PTEN-dependent mitochondrial metabolic dysfunction promotes Pseudomonas aeruginosa airway infection.
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Changes in the transcriptome of bovine ovarian cortex during follicle activation in vitro.
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Chemoresistant KM12C colon cancer cells are addicted to low cyclic AMP levels in a phosphodiesterase 4-regulated compartment via effects on phosphoinositide 3-kinase.
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Chemotactic Cues for NOTCH1-Dependent Leukemia.
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Chromosomal basis of adenocarcinoma of the prostate.
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Cilostazol enhances casein kinase 2 phosphorylation and suppresses tumor necrosis factor-alpha-induced increased phosphatase and tensin homolog deleted from chromosome 10 phosphorylation and apoptotic cell death in SK-N-SH cells.
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Cilostazol prevents tumor necrosis factor-alpha-induced cell death by suppression of phosphatase and tensin homolog deleted from chromosome 10 phosphorylation and activation of Akt/cyclic AMP response element-binding protein phosphorylation.
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Circular RNA circ-PTEN elevates PTEN inhibiting the proliferation of non-small cell lung cancer cells.
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Cisplatin-induced caspase activation mediates PTEN cleavage in ovarian cancer cells: a potential mechanism of chemoresistance.
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Class I histone deacetylase inhibitor suppresses vasculogenic mimicry by enhancing the expression of tumor suppressor and anti-angiogenesis genes in aggressive human TNBC cells.
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Clinical Analysis of PTEN, p53 and Her-2/neu Expressions in Thyroid Cancers.
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Clinical and Histologic Overlap and Distinction Among Various Hamartomatous Polyposis Syndromes.
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Clinical and In Silico Outcomes of miR-130a-5p and miR-615-3p Expression in Tumor Compared with Non-Tumor Adjacent Tissues of Patients with BC.
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Clinical and sonographic features of pediatric soft-tissue vascular anomalies part 2: vascular malformations.
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Clinical impact of PTEN methylation status as a prognostic marker for breast cancer.
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Clinical implications of PTEN loss in prostate cancer.
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Clinical significance of tumor suppressor PTEN in colorectal carcinoma.
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Clinical Value of lncRNA MEG3 in High-Grade Serous Ovarian Cancer.
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Clinicopathologic and Molecular Analysis of a Choroidal Pigmented Schwannoma in the Context of a PTEN Hamartoma Tumor Syndrome.
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Clinicopathological significance of nuclear PTEN expression in colorectal adenocarcinoma.
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Clofarabine, a novel adenosine analogue, reactivates DNA methylation-silenced tumour suppressor genes and inhibits cell growth in breast cancer cells.
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Clofarabine?phytochemical combination exposures in CML cells inhibit DNA methylation machinery, upregulate tumor suppressor genes and promote caspase?dependent apoptosis.
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Colonic ganglioneuromatous polyposis and metastatic adenocarcinoma in the setting of Cowden syndrome: a case report and literature review.
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Colonic manifestations of PTEN hamartoma tumor syndrome: case series and systematic review.
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Colonic polyps and polyposis syndromes in pediatric patients.
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Combinatorial therapy with adenoviral-mediated PTEN and a PI3K inhibitor suppresses malignant glioma cell growth in vitro and in vivo by regulating the PI3K/AKT signaling pathway.
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Combined Casein Kinase II inhibition and epigenetic modulation in acute B-lymphoblastic leukemia.
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Combined Effects of Genetic Variants of the PTEN, AKT1, MDM2 and p53 Genes on the Risk of Nasopharyngeal Carcinoma.
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Combined p53- and PTEN-deficiency activates expression of mesenchyme homeobox 1 (MEOX1) required for growth of triple-negative breast cancer.
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Combined PTEN Mutation and Protein Expression Associate with Overall and Disease-Free Survival of Glioblastoma Patients.
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Combined treatment with everolimus and fulvestrant reversed anti-HER2 resistance in a patient with refractory advanced breast cancer: a case report.
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Commentary on The Deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network Song MS, Salmena L, Carracedo A, Egia A, Lo-Coco F, Teruya-Feldstein J, Pandolfi PP, Cancer Genetics Program, Beth Israel Deaconess Cancer Center and Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.
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Comparative analysis of SV40 17kT and LT function in vivo demonstrates that LT's C-terminus re-programs hepatic gene expression and is necessary for tumorigenesis in the liver.
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Comparative effects of retinoic acid, vitamin D and resveratrol alone and in combination with adenosine analogues on methylation and expression of phosphatase and tensin homologue tumour suppressor gene in breast cancer cells.
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Comparison of the PI3KCA pathway in circulating tumor cells and corresponding tumor tissue of patients with metastatic breast cancer.
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Comprehensive Analysis of PTEN in Primary Cutaneous Melanoma.
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Concerted roles of PTEN and ATM in controlling hematopoietic stem cell fitness and dormancy.
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Concurrent deletion of 16q23 and PTEN is an independent prognostic feature in prostate cancer.
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Conditional deletion of Pten causes bronchiolar hyperplasia.
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Conditional deletion of pten leads to defects in nerve innervation and neuronal survival in inner ear development.
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Conditional expression of PTEN alters the androgen responsiveness of prostate cancer cells.
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Conditional Inactivation of Pten with EGFR Overexpression in Schwann Cells Models Sporadic MPNST.
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Connection between Tumor Suppressor BRCA1 and PTEN in Damaged DNA Repair.
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Control of fibroblast fibronectin expression and alternative splicing via the PI3K/Akt/mTOR pathway.
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Control of phosphatase and tensin homolog (PTEN) gene expression in normal and neoplastic thyroid cells.
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Controlling PTEN (Phosphatase and Tensin Homolog) Stability: A DOMINANT ROLE FOR LYSINE 66.
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Converting cancer mutations into therapeutic opportunities.
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Cooperative phosphorylation of the tumor suppressor phosphatase and tensin homologue (PTEN) by casein kinases and glycogen synthase kinase 3beta.
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Coordinate activation of Shh and PI3K signaling in PTEN-deficient glioblastoma: new therapeutic opportunities.
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Correlates and determinants of nuclear epidermal growth factor receptor content in an oropharyngeal cancer tissue microarray.
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Correlation between NDRG1 and PTEN expression in endometrial carcinoma.
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Correspondence re: W.M. Lin et al., loss of heterozygosity and mutational analysis of the PTEN/MMAC1 gene in synchronous endometrial and ovarian carcinomas. Clin. Cancer Res., 4: 2577-2583, 1998.
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Counteracting the activation of pAkt by inhibition of MEK/Erk inhibition reduces actin disruption-mediated apoptosis in PTEN-null PC3M prostate cancer cell lines.
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Cowden syndrome and the PTEN hamartoma tumor syndrome: systematic review and revised diagnostic criteria.
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Cowden Syndrome with a Novel Germline PTEN Mutation and an Unusual Clinical Course.
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Cowden syndrome- Clinico-radiological illustration of a rare case.
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Cowden Syndrome: Case Report, Update and Proposed Diagnostic and Surveillance Routines.
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CREB is a Novel Nuclear Target of PTEN Phosphatase.
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Critical role of PICT-1, a tumor suppressor candidate, in phosphatidylinositol 3,4,5-trisphosphate signals and tumorigenic transformation.
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CRKL Mediates p110?-Dependent PI3K Signaling in PTEN-Deficient Cancer Cells.
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Crosstalk between PTEN/Akt2 and TGFbeta signaling involving EGF receptor down-regulation during the tumor promotion process from the early stage in a rat two-stage hepatocarcinogenesis model.
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Cul4B is a novel prognostic marker in cholangiocarcinoma.
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Cytosolic phospholipase A2? sustains pAKT, pERK and AR levels in PTEN-null/mutated prostate cancer cells.
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DAPT suppresses proliferation and migration of hepatocellular carcinoma by regulating the extracellular matrix and inhibiting the Hes1/PTEN/AKT/mTOR signaling pathway.
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Deletion of PTEN promotes tumorigenic signaling, resistance to anoikis, and altered response to chemotherapeutic agents in human mammary epithelial cells.
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Deletions in the long arm of chromosome 10 in lymphomas with t(14;18): a pathogenetic role of the tumor supressor genes PTEN/MMAC1 and MXI1?
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Denaturing high performance liquid chromatography (DHPLC) used in the detection of germline and somatic mutations.
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Deregulation of a STAT3-interleukin 8 signaling pathway promotes human glioblastoma cell proliferation and invasiveness.
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Deregulation of PTEN Expression in Laryngeal Squamous Cell Carcinoma Based on Tissue Microarray Digital Analysis.
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Deregulation of the Akt pathway in human cancer.
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Dermatofibrosarcoma Protuberans in a Patient With Cowden Syndrome: Revisiting the PTEN and PDGF Pathways.
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Detection of new PTEN/MMAC1 mutations in head and neck squamous cell carcinomas with loss of chromosome 10.
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Determining risk of biochemical recurrence in prostate cancer by immunohistochemical detection of PTEN expression and Akt activation.
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Development of an immunohistochemical protein quantification system in conjunction with tissue microarray technology for identifying predictive biomarkers for phosphatidylinositol 3-kinase inhibitors.
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Development of Potent Adenosine Monophosphate Activated Protein Kinase (AMPK) Activators.
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Diagnostic potential of PTEN-targeting miR-214 in the blood of breast cancer patients.
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Dietary exposure to whey proteins alters rat mammary gland proliferation, apoptosis, and gene expression during postnatal development.
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Differential Akt signalling in non-seminomatous testicular germ cell tumors.
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Differential expression of long non-coding RNA and mRNA in children with Henoch-Schönlein purpura nephritis.
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Differential expression of PTEN in normal adult rat brain and upregulation of PTEN and p-Akt in the ischemic cerebral cortex.
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Differential expression of PTEN-targeting microRNAs miR-19a and miR-21 in Cowden syndrome.
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Differential Methylation and Acetylation as the Epigenetic Basis of Resveratrol's Anticancer Activity.
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Differential micro ribonucleic acid expression profiling in ovarian endometrioma with leuprolide acetate treatment.
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Differential Requirement for Pten Lipid and Protein Phosphatase Activity during Zebrafish Embryonic Development.
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Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein.
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Discovery and functional characterization of a neomorphic PTEN mutation.
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Discovery and optimization of new benzimidazole- and benzoxazole-pyrimidone selective PI3K? inhibitors for the treatment of phosphatase and TENsin homologue (PTEN)-deficient cancers.
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Discovery and optimization of pyrimidone indoline amide PI3K? inhibitors for the treatment of phosphatase and tensin homologue (PTEN)-deficient cancers.
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Discovery of a Phosphoinositide 3-Kinase (PI3K) ?/? Inhibitor for the Treatment of Phosphatase and Tensin Homolog (PTEN) Deficient Tumors: Building PI3K? Potency in a PI3K?-Selective Template by Targeting Nonconserved Asp856.
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Dissecting the signaling pathways that mediate cancer in PTEN and LKB1 double-knockout mice.
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Distinct patterns of deletion on 10p and 10q suggest involvement of multiple tumor suppressor genes in the development of astrocytic gliomas of different malignancy grades.
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Distinct roles for PTEN in prevention of T cell lymphoma and autoimmunity in mice.
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DJ-1-induced phosphatase and tensin homologue downregulation is associated with proliferative and invasive activity of laryngeal cancer cells.
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DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury.
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DNA damage response as a prognostic indicator in metastatic breast cancer via mutational analysis.
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DNA methylation inhibitor, decitabine, promotes MGC803 gastric cancer cell migration and invasion via the upregulation of NEDD4?1.
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Down-regulated lncRNA TP73-AS1 reduces radioresistance in hepatocellular carcinoma via the PTEN/Akt signaling pathway.
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Downregulation of Hsp27 (HSPB1) in MCF-7 human breast cancer cells induces upregulation of PTEN.
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Downregulation of MACC1 inhibits the viability, invasion and migration and induces apoptosis in esophageal carcinoma cells through the phosphatase and tensin homolog/phosphoinositide 3-kinase/protein kinase B signaling pathway.
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Downregulation of microRNA?25?3p inhibits the proliferation and promotes the apoptosis of multiple myeloma cells via targeting the PTEN/PI3K/AKT signaling pathway.
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Downregulation of PTEN expression in psoriatic lesions.
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Downregulation of Spry2 by miR-21 triggers malignancy in human gliomas.
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Downregulation of STRAP promotes tumor growth and metastasis in hepatocellular carcinoma via reducing PTEN level.
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Dynamics and structural stability effects of germline PTEN mutations associated with cancer versus autism phenotypes.
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Dysregulated Expression of Phosphorylated Epidermal Growth Factor Receptor and Phosphatase and Tensin Homologue in Canine Cutaneous Papillomas and Squamous Cell Carcinomas.
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Dysregulation of AKT Pathway by SMYD2-Mediated Lysine Methylation on PTEN.
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E- to N-cadherin switch in melanoma is associated with decreased expression of phosphatase and tensin homolog and cancer progression.
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Ear atresia: Is there a role of apoptosis-regulating miRNAs?
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Ectodomain-specific E-cadherin antibody suppresses skin SCC growth and reduces tumor grade: a multitargeted therapy modulating RTKs and the PTEN-p53-MDM2 axis.
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Effect and mechanism of microRNA-10b on proliferation and invasion of esophageal cancer cells.
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Effect of the PTEN gene on adhesion, invasion and metastasis of osteosarcoma cells.
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Effects of PTEN inhibition on regulation of tau phosphorylation in an okadaic acid-induced neurodegeneration model.
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Effects of Tacrolimus and Nifedipine Alone or in Combination on the Gingival Tissues.
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Effects of the tumor suppressor PTEN on the pathogenesis of idiopathic pulmonary fibrosis in Chinese patients.
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Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN.
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Emerging biomarkers in glioblastoma.
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Emerging targets in the AKT pathway for treatment of androgen-independent prostatic adenocarcinoma.
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Endometrial tumorigenesis in Pten(+/-) mice is independent of coexistence of estrogen and estrogen receptor ?.
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Endoscopic Findings in Patients With PTEN Hamartoma Tumor Syndrome Undergoing Surveillance.
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Engineering ePTEN, an enhanced PTEN with increased tumor suppressor activities.
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Enhanced lymphocyte interferon (IFN)-? responses in a PTEN mutation-negative Cowden disease kindred.
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Enhanced tumor suppression by adenoviral PTEN gene therapy combined with cisplatin chemotherapy in small-cell lung cancer.
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Enhancement of antitumor activity of the anti-EGF receptor monoclonal antibody cetuximab/C225 by perifosine in PTEN-deficient cancer cells.
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Enhancer of zeste homolog 2 is overexpressed and contributes to epigenetic inactivation of p21 and phosphatase and tensin homolog in B-cell acute lymphoblastic leukemia.
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Epidermal growth factor receptor inhibitors in oncology.
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Epigallocatechin-3-gallate promotes all-trans retinoic acid-induced maturation of acute promyelocytic leukemia cells via PTEN.
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Epigenetic Downregulation of PTEN in Gallbladder Cancer.
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Epigenetic modulation of PTEN expression during antiandrogenic therapies in human prostate cancer.
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Epigenetic regulator UHRF1 inactivates REST and growth suppressor gene expression via DNA methylation to promote axon regeneration.
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Epigenetic silencing of the PTEN gene in melanoma.
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Epithelial phosphatase and tensin homolog regulates intestinal architecture and secretory cell commitment and acts as a modifier gene in neoplasia.
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Establishment and antitumor effects of dasatinib and PKI-587 in BD-138T, a patient-derived muscle invasive bladder cancer preclinical platform with concomitant EGFR amplification and PTEN deletion.
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Estrogen receptor ? induces down-regulation of PTEN through PI3-kinase activation in breast cancer cells.
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Estrogen receptor ?, a regulator of androgen receptor signaling in the mouse ventral prostate.
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Evidence of mTOR Activation by an AKT-Independent Mechanism Provides Support for the Combined Treatment of PTEN-Deficient Prostate Tumors with mTOR and AKT Inhibitors.
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Exogenous induction of unphosphorylated PTEN reduces TGF?-induced extracellular matrix expressions in lung fibroblasts.
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Exosomes derived from normal human bronchial epithelial cells down-regulate proliferation and migration of hydroquinone-transformed malignant recipient cells via up-regulating PTEN expression.
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Exploiting Chromosomal Instability of PTEN-Deficient Triple-Negative Breast Cancer Cell Lines for the Sensitization against PARP1 Inhibition in a Replication-Dependent Manner.
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Expression and significance of PTEN and Claudin-3 in prostate cancer.
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Expression and significance of PTEN and miR-92 in hepatocellular carcinoma.
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Expression and significance of PTEN in canine mammary gland tumours.
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Expression of phosphatase and tensin homolog, epidermal growth factor receptor, and Ki-67 in astrocytoma: A prospective study in a tertiary care hospital.
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Expression of Phosphatase and Tensin Homologue, phospho-Akt, and p53 in Acral Benign and Malignant Melanocytic Neoplasms (Benign Nevi, Dysplastic Nevi, and Acral Melanomas).
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Expression of PIK3CA, PTEN mRNA and PIK3CA mutations in primary breast cancer: association with lymph node metastases.
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Expression of PPAR? and PTEN in human colorectal cancer: An immunohistochemical study using tissue microarray methodology.
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Expression of PTEN and KAI1 tumor suppressor genes in pancreatic carcinoma and its association with different pathological factors.
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Expression of PTEN in ovarian epithelial tumors and its relation to tumor behavior and growth.
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Expression of PTEN, cyclin D1, P27/KIP1 in invasive ductal carcinomas of the breast and correlation with clinicopathological parameters.
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Expression of PTTG1 and PTEN in endometrial carcinoma: correlation with tumorigenesis and progression.
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Expression of ribonucleotide reductase M2 subunit in gastric cancer and effects of RRM2 inhibition in vitro.
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Expression of the PTEN tumor suppressor gene in malignant mammary gland tumors of dogs.
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Expression, purification, characterization and homology modeling of active Akt/PKB, a key enzyme involved in cell survival signaling.
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FGFR and PTEN signaling interact during lens development to regulate cell survival.
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Fibroblast-derived CXCL12 regulates PTEN expression and is associated with the proliferation and invasion of colon cancer cells via PI3k/Akt signaling.
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Fibronectin induces cell proliferation and inhibits apoptosis in human bronchial epithelial cells: pro-oncogenic effects mediated by PI3-kinase and NF-kappa B.
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Fibronectin stimulates non-small cell lung carcinoma cell growth through activation of Akt/mammalian target of rapamycin/S6 kinase and inactivation of LKB1/AMP-activated protein kinase signal pathways.
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First application of the Automated QUantitative Analysis (AQUA) technique to quantify PTEN protein expression in ovarian cancer: A correlative study of NCIC CTG OV.16.
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First case report of malignant peritoneal mesothelioma and oral verrucous carcinoma in a patient with a germline PTEN mutation: a combination of extremely rare diseases with probable further implications.
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First Molecular Genetic Characterization of Skene's Gland Adenocarcinoma.
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First-in-human trial of the PI3K?-selective inhibitor SAR260301 in patients with advanced solid tumors.
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Focal adhesion kinase phosphorylates the phosphatase and tensin homolog deleted on chromosome 10 under the control of p110? phosphoinositide-3 kinase.
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Focal adhesion kinase: a promising target for anticancer therapy.
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Focus on PTEN Regulation.
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Folic acid conjugated polymeric micelles loaded with a curcumin difluorinated analog for targeting cervical and ovarian cancers.
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Four MicroRNAs Promote Prostate Cell Proliferation with Regulation of PTEN and Its Downstream Signals In Vitro.
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FOXO factors: a matter of life and death.
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FOXO1/3 and PTEN Depletion in Granulosa Cells Promotes Ovarian Granulosa Cell Tumor Development.
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FOXO3 Is Inhibited by Oncogenic PI3K/Akt Signaling but Can Be Reactivated by the NSAID Sulindac Sulfide.
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Frequent genetic alterations in EGFR- and HER2-driven pathways in breast cancer brain metastases.
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Frequent inactivation of PTEN in prostate cancer cell lines and xenografts.
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Frequent inactivation of PTEN/MMAC1 in primary prostate cancer.
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Frequent mono-allelic loss associated with deficient PTEN expression in imatinib-resistant gastrointestinal stromal tumors.
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Frequent PTEN loss and differential HER2/PI3K signaling pathway alterations in salivary duct carcinoma: Implications for targeted therapy.
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Frequent PTEN/MMAC mutations in endometrioid but not serous or mucinous epithelial ovarian tumors.
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From adrenarche to aging of adrenal zona reticularis: precocious female adrenopause onset.
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Fructose and the metabolic syndrome: pathophysiology and molecular mechanisms.
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Functional definition of relevant epitopes on the tumor suppressor PTEN protein.
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Functional genomics identifies specific vulnerabilities in PTEN-deficient breast cancer.
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Functional interaction of phosphatase and tensin homologue (PTEN) with the E3 ligase NEDD4-1 during neuronal response to zinc.
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Functions and Regulation of the PTEN Gene in Colorectal Cancer.
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G protein-coupled receptor-mediated activation of p110? by G?? is required for cellular transformation and invasiveness.
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Galectin-3 and PTEN expression in pancreatic ductal adenocarcinoma, pancreatic neuroendocrine neoplasms and gastrointestinal tumors on fine-needle aspiration cytology.
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Ganglioside GM3 modulates tumor suppressor PTEN-mediated cell cycle progression--transcriptional induction of p21(WAF1) and p27(kip1) by inhibition of PI-3K/AKT pathway.
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GAS5 knockdown reduces the chemo-sensitivity of non-small cell lung cancer (NSCLC) cell to cisplatin (DDP) through regulating miR-21/PTEN axis.
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GDC-0980 is a novel class I PI3K/mTOR kinase inhibitor with robust activity in cancer models driven by the PI3K pathway.
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GDNF family receptor alpha 2 promotes neuroblastoma cell proliferation by interacting with PTEN.
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Generation of PTEN?knockout (?/?) murine prostate cancer cells using the CRISPR/Cas9 system and comprehensive gene expression profiling.
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Genetic alterations and expression of PTEN and its relationship with cancer stem cell markers to investigate pathogenesis and to evaluate prognosis in hepatocellular carcinoma.
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Genetic alterations and oncogenic pathways associated with breast cancer subtypes.
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Genetic alterations in the RAS/RAF/mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt signaling pathways in the follicular variant of papillary thyroid carcinoma.
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Genetic alterations of the tumor suppressor gene PTEN/MMAC1 in human brain metastases.
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Genetic and epigenetic alterations of the PTEN gene in soft tissue sarcomas.
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Genetic basis of Cowden syndrome and its implications for clinical practice and risk management.
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Genetic Landscape of Prostate Cancer Conspicuity on Multiparametric Magnetic Resonance Imaging: A Systematic Review and Bioinformatic Analysis.
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Genetic profile of PTEN gene in Indian oral squamous cell carcinoma primary tumors.
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Genetic reconstitution of tumorigenesis in primary intestinal cells.
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Genetics of endometrial cancer.
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Genistein inhibits DNA methylation and increases expression of tumor suppressor genes in human breast cancer cells.
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Genodermatosis Affecting the Skin and Mucosa of the Head and Neck: Clinicopathologic, Genetic, and Molecular Aspect-PTEN-Hamartoma Tumor Syndrome/Cowden Syndrome.
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Genome-wide search for loss of heterozygosity in Chinese patients with sporadic colorectal cancer.
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Genomic characterization of sarcomatoid transformation in clear cell renal cell carcinoma.
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Genomic Database Analysis for Head and Neck Cancer Prevention Targets: MTOR Signal Transduction Pathway.
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Genomic Deletion at 10q23 in Prostate Cancer: More Than PTEN Loss?
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Genomic Predictors of Outcome in Prostate Cancer.
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Genomic Rearrangements of PTEN in Prostate Cancer.
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Genotypic analysis of tumor suppressor genes PTEN/MMAC1 and p53 in head and neck squamous cell carcinomas.
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Gentamicin Targets Acid Sphingomyelinase in Cancer: The Case of the Human Gastric Cancer NCI-N87 Cells.
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Germline epigenetic regulation of KILLIN in Cowden and Cowden-like syndrome.
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Germline mutations in the PTEN/MMAC1 gene in patients with Cowden disease.
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Germline mutations of p53 but not p16/CDKN2 or PTEN/MMAC1 tumor suppressor genes predispose to gliomas. The ANOCEF Group. Association des NeuroOncologues d'Expression Française.
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Germline PTEN mutations are associated with a skewed peripheral immune repertoire in humans and mice.
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Glioblastoma Therapy: Rationale for a Mesenchymal Stem Cell-based Vehicle to Carry Recombinant Viruses.
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Glioma cell VEGFR-2 confers resistance to chemotherapeutic and antiangiogenic treatments in PTEN-deficient glioblastoma.
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Global or Granulosa Cell-Specific Pten Mutations in Combination with Elevated FSH Levels Fail to Cause Ovarian Tumours in Mice.
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Grb2 binds to PTEN and regulates its nuclear translocation to maintain the genomic stability in DNA damage response.
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Growth inhibition of human malignant glioma cells induced by the PI3-K-specific inhibitor.
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Hamartomatous polyposis syndromes.
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HBV-Induced Increased N6 Methyladenosine Modification of PTEN RNA Affects Innate Immunity and Contributes to HCC.
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Hepatocyte-specific Pten-deficient mice as a novel model for nonalcoholic steatohepatitis and hepatocellular carcinoma.
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Herpes simplex virus type 1 VP22-mediated intercellular delivery of PTEN increases the antitumor activity of PTEN in esophageal squamous cell carcinoma cells in vitro and in vivo.
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Hesperidin induces apoptosis and triggers autophagic markers through inhibition of Aurora-A mediated phosphoinositide-3-kinase/Akt/mammalian target of rapamycin and glycogen synthase kinase-3 beta signalling cascades in experimental colon carcinogenesis.
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Heterogeneity and chronology of PTEN deletion and ERG fusion in prostate cancer.
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Heterogeneity in the colorectal primary tumor and the synchronous resected liver metastases prior to and after treatment with an anti-EGFR monoclonal antibody.
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Heterozygous disruption of the PTEN promotes intestinal neoplasia in APCmin/+ mouse: roles of osteopontin.
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Hidden association of Cowden syndrome, PTEN mutation and meningioma frequency.
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High dietary inorganic phosphate increases lung tumorigenesis and alters Akt signaling.
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High levels of phosphatase and tensin homolog expression are associated with tumor progression, tumor recurrence, and systemic metastases in pT1 urothelial carcinoma of the bladder: a tissue microarray study of 156 patients treated by transurethral resection.
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High-grade glioma formation results from postnatal pten loss or mutant epidermal growth factor receptor expression in a transgenic mouse glioma model.
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Higher methylation intensity induced by EBV LMP1 via NF-?B/ DNMT3b signaling contributes to silencing of PTEN gene.
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Hotspot Mutations Detectable by Next-generation Sequencing in Exhaled Breath Condensates from Patients with Lung Cancer.
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Hsa_circ_0033155: A potential novel biomarker for non-small cell lung cancer.
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Hsp27 silencing coordinately inhibits proliferation and promotes Fas-induced apoptosis by regulating the PEA-15 molecular switch.
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Human fibroblast reprogramming to pluripotent stem cells regulated by the miR19a/b-PTEN axis.
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Hyaluronic acid-functionalized gelatin hydrogels reveal extracellular matrix signals temper the efficacy of erlotinib against patient-derived glioblastoma specimens.
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Hydrogen sulfide prevents hydrogen peroxide-induced activation of epithelial sodium channel through a PTEN/PI(3,4,5)P3 dependent pathway.
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Hypoxia aggravates nonalcoholic steatohepatitis in mice lacking hepatocellular PTEN.
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Identification and structure-activity relationship of 2-morpholino 6-(3-hydroxyphenyl) pyrimidines, a class of potent and selective PI3 kinase inhibitors.
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Identification of a novel PTEN intronic deletion in Li-Fraumeni syndrome and its effect on RNA processing.
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Identification of a pseudogene that can masquerade as a mutant allele of the PTEN/MMAC1 tumor suppressor gene.
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Identification of microprocessor-dependent cancer cells allows screening for growth-sustaining micro-RNAs.
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Identification of PTEN/MMAC1 alterations in uncultured melanomas and melanoma cell lines.
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Identifying Differentially Expressed MicroRNAs, Target Genes, and Key Pathways Deregulated in Patients with Liver Diseases.
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IGF-II and IGFBP-2 differentially regulate PTEN in human breast cancer cells.
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IGF1-induced AKT phosphorylation and cell proliferation are suppressed with the increase in PTEN during luteinization in human granulosa cells.
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IL-6/STAT3/ARF: the guardians of senescence, cancer progression and metastasis in prostate cancer.
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ILF2 promotes anchorage independence through direct regulation of PTEN.
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Imaging of PTEN-related abnormalities in the central nervous system.
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Immune checkpoint blockade as a potential therapeutic target: surveying CNS malignancies.
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Immunocytochemical mapping of the phosphatase and tensin homolog (PTEN/MMAC1) tumor suppressor protein in human gliomas.
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Immunohistochemical analysis of PTEN in endometrial carcinoma: a tissue microarray study with a comparison of four commercial antibodies in correlation with molecular abnormalities.
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Immunohistochemical expression of mTOR negatively correlates with PTEN expression in gastric carcinoma.
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Immunohistochemical expression of phosphatase and tensin homolog in histologic gradings of oral squamous cell carcinoma.
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Impact of decitabine on immunohistochemistry expression of the putative tumor suppressor genes FHIT, WWOX, FUS1 and PTEN in clinical tumor samples.
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Impact of PTEN IVS4 Polymorphism (rs3830675) on Cancer Susceptibility: An Updated Meta-analysis.
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Implication of PTEN in production of reactive oxygen species and neuronal death in in vitro models of stroke and Parkinson's disease.
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In silico approach of naringin as potent phosphatase and tensin homolog (PTEN) protein agonist against prostate cancer.
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In utero and lactational exposure to blueberry via maternal diet promotes mammary epithelial differentiation in prepubescent female rats.
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In utero exposure to maternal diets containing soy protein isolate, but not genistein alone, protects young adult rat offspring from NMU-induced mammary tumorigenesis.
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In vitro loss of heterozygosity targets the PTEN/MMAC1 gene in melanoma.
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In vivo longitudinal imaging of RNA interference-induced endocrine therapy resistance in breast cancer.
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Inactivation of Rac1 reduces Trastuzumab resistance in PTEN deficient and insulin-like growth factor I receptor overexpressing human breast cancer SKBR3 cells.
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Inactivation of the candidate tumor suppressor par-4 in endometrial cancer.
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Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression.
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Increase of fatty acid oxidation and VLDL assembly and secretion overexpression of PTEN in cultured hepatocytes of newborn calf.
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Increase of phosphatase and tensin homolog by silymarin to inhibit human pharynx squamous cancer.
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Increased Activated Akt Expression in Renal Cell Carcinomas and Prognosis.
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Increased expression of Mcl-1 is required for protection against serum starvation in phosphatase and tensin homologue on chromosome 10 null mouse embryonic fibroblasts, but repression of Bim is favored in human glioblastomas.
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Increased nuclear phosphatase and tensin homologue deleted on chromosome 10 is associated with G0-G1 in MCF-7 cells.
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Increased phosphorylation of 4E?binding protein 1 predicts poor prognosis for patients with colorectal cancer.
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Increased PTEN expression due to transcriptional activation of PPARgamma by Lovastatin and Rosiglitazone.
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Increased tissue factor expression is associated with reduced survival in non-small cell lung cancer and with mutations of TP53 and PTEN.
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Indole-3-carbinol inhibits tumorigenicity of hepatocellular carcinoma cells via suppression of microRNA-21 and upregulation of phosphatase and tensin homolog.
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Infantile Lhermitte-Duclos Disease Treated Successfully With Rapamycin.
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Infrequent genetic alterations of the PTEN/MMAC1 gene in Japanese patients with primary cancers of the breast, lung, pancreas, kidney, and ovary.
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Infrequent genetic alterations of the tumor suppressor gene PTEN/MMAC1 in squamous cell carcinoma of the oral cavity.
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Infrequent mutations in the PTEN/MMAC1 gene among primary breast cancers.
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Inhibition of apoptosis by MAD1 is mediated by repression of the PTEN tumor suppressor gene.
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Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN.
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Inhibition of ILK in PTEN-mutant human glioblastomas inhibits PKB/Akt activation, induces apoptosis, and delays tumor growth.
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Inhibition of LPS-induced cyclooxygenase 2 and nitric oxide production by transduced PEP-1-PTEN fusion protein in Raw 264.7 macrophage cells.
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Inhibition of phosphatidylinositol-3-OH kinase/Akt signaling impairs DNA repair in glioblastoma cells following ionizing radiation.
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Inhibition of PI3K-AKT-mTOR pathway sensitizes endometrial cancer cell lines to PARP inhibitors.
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Inhibition of protein kinase B/Akt. implications for cancer therapy.
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Inhibition of PTEN activity aggravates cisplatin-induced acute kidney injury.
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Inhibition of T-cell activation by PIK3IP1.
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Inhibition of the phosphatidylinositol 3-kinase pathway contributes to HT29 and Caco-2 intestinal cell differentiation.
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Inhibitors of mTOR reverse doxorubicin resistance conferred by PTEN status in prostate cancer cells.
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Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers.
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Insights into the targeting potential of thymoquinone for therapeutic intervention against triple-negative breast cancer.
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Interaction of E-cadherin and PTEN Regulates Morphogenesis and Growth Arrest in Human Mammary Epithelial Cells.
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Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase.
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Interference of P-REX2a may inhibit proliferation and reverse the resistance of SGC7901 cells to doxorubicin.
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Interfocal heterogeneity of PTEN/MMAC1 gene alterations in multiple metastatic prostate cancer tissues.
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Interleukin-1?/nuclear factor-?B signaling promotes osteosarcoma cell growth through the microRNA-181b/phosphatase and tensin homolog axis.
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Intracellular delivery of the PTEN protein using cationic lipidoids for cancer therapy.
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Intragenic PTEN/MMAC1 loss of heterozygosity in conventional (clear-cell) renal cell carcinoma is associated with poor patient prognosis.
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Investigation of PTEN promoter methylation in ameloblastoma.
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Involvement of human micro-RNA in growth and response to chemotherapy in human cholangiocarcinoma cell lines.
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Involvement of IGF-2, IGF-1R, IGF-2R and PTEN in development of human tooth germ - an immunohistochemical study.
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Involvement of phosphatase and tensin homolog deleted from chromosome 10 in rodent model of neuropathic pain.
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Irs2 inactivation suppresses tumor progression in Pten+/- mice.
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Is colorectal surveillance indicated in patients with PTEN mutations?
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Is exon 5 of the PTEN/MMAC1 gene a prognostic marker in anaplastic glioma?
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Is NEDD4-1 a negative regulator of phosphatase and tensin homolog in gastric carcinogenesis?
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Is STAT3 and PTEN Expression Altered in Canine Prostate Cancer?
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Isolation and characterization of adult mammary stem cells from breast cancer-adjacent tissues.
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Isolation, cultivation and identification of brain glioma stem cells by magnetic bead sorting.
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KRAS Mutation Status and Clinical Outcome of Preoperative Chemoradiation With Cetuximab in Locally Advanced Rectal Cancer: A Pooled Analysis of 2 Phase II Trials.
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Kruppel-Like Factor 9 Loss-of-Expression in Human Endometrial Carcinoma Links Altered Expression of Growth-Regulatory Genes with Aberrant Proliferative Response to Estrogen.
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Lapatinib antitumor activity is not dependent upon phosphatase and tensin homologue deleted on chromosome 10 in ErbB2-overexpressing breast cancers.
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Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation.
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Lentivirus-mediated RNA interference targeting E2F-1 inhibits human gastric cancer MGC-803 cell growth in vivo.
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Letter regarding Xiao WZ et al. entitled "Relationships between PTEN gene mutations and prognosis in glioma: a meta-analysis".
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Lhermitte-Duclos disease as a component of Cowden's syndrome. Case report and review of the literature.
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LINC00470 Stimulates Methylation of PTEN to Facilitate the Progression of Endometrial Cancer by Recruiting DNMT3a Through MYC.
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Lipid phosphatase SHIP2 functions as oncogene in colorectal cancer by regulating PKB activation.
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Liver X receptors constrain tumor development and metastasis dissemination in PTEN-deficient prostate cancer.
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LncRNA cancer susceptibility candidate (CASC7) upregulates phosphatase and tensin homolog by downregulating miR-10a to inhibit neuroblastoma cell proliferation.
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LncRNA TUSC8 inhibits the invasion and migration of cervical cancer cells via miR-641/PTEN axis.
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Long non-coding RNA phosphatase and tensin homolog pseudogene 1 suppresses osteosarcoma cell growth via the phosphoinositide 3-kinase/protein kinase B signaling pathway.
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Long noncoding RNA ALOX12-AS1 inhibits cervical cancer cells proliferation via targeting miR-3171.
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Long Noncoding RNA GATA3-AS1 Promotes Cell Proliferation and Metastasis in Hepatocellular Carcinoma by Suppression of PTEN, CDKN1A, and TP53.
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Long noncoding RNA Linc02023 regulates PTEN stability and suppresses tumorigenesis of colorectal cancer in a PTEN-dependent pathway.
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Long-term androgen-ablation causes increased resistance to PI3K/Akt pathway inhibition in prostate cancer cells.
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Longitudinal Cell-Free DNA Analysis in Patients with Small Cell Lung Cancer Reveals Dynamic Insights into Treatment Efficacy and Disease Relapse.
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Loss and reduced expression of PTEN correlate with advanced-stage gastric carcinoma.
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Loss of ARID1A Promotes Hepatocellular Carcinoma Progression via Up-regulation of MYC Transcription.
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Loss of Expression of PTEN is Associated with Worse Prognosis in Patients with Cancer.
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Loss of heterozygosity and mutational analysis of the PTEN/MMAC1 gene in synchronous endometrial and ovarian carcinomas.
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Loss of heterozygosity at 10q in tumors of the upper respiratory tract is associated with poor prognosis.
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Loss of heterozygosity in the MXI1 gene is a frequent occurrence in melanoma.
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Loss of heterozygosity on chromosome 10q23 and mutation of the phosphatase and tensin homolog deleted from chromosome 10 tumor suppressor gene in Korean hepatocellular carcinoma patients.
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Loss of p(Ser2448) -mTOR expression is linked to adverse prognosis and tumor progression in ERG-fusion-positive cancers.
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Loss of phosphatase and tensin homolog enhances cell invasion and migration through AKT/Sp-1 transcription factor/matrix metalloproteinase 2 activation in hepatocellular carcinoma and has clinicopathologic significance.
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Loss of phosphatase and tensin homolog expression correlates with clinicopathological features of non-small cell lung cancer patients and its impact on survival: A systematic review and meta-analysis.
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Loss of phosphatase and tensin homolog expression is associated with recurrence and poor prognosis in patients with pancreatic ductal adenocarcinoma.
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Loss of phosphatase and tensin homolog or phosphoinositol-3 kinase activation and response to trastuzumab or lapatinib in human epidermal growth factor receptor 2-overexpressing locally advanced breast cancers.
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Loss of Phosphatase and Tensin Homolog Protein Expression Is an Independent Poor Prognostic Marker in Lung Adenocarcinoma.
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Loss of Phosphatase and Tensin Homologue Deleted on Chromosome 10 Engages ErbB3 and Insulin-Like Growth Factor-I Receptor Signaling to Promote Antiestrogen Resistance in Breast Cancer.
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Loss of phosphatase and tensin homologue increases transforming growth factor beta-mediated invasion with enhanced SMAD3 transcriptional activity.
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Loss of PTEN causes SHP2 activation, making lung cancer cells unresponsive to IFN-?.
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Loss of PTEN expression as diagnostic marker of endometrial precancer: A systematic review and meta-analysis.
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Loss of PTEN expression is associated with colorectal cancer liver metastasis and poor patient survival.
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Loss of PTEN is associated with elevated EGFR and HER2 expression and worse prognosis in salivary gland cancer.
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Loss of PTEN sensitizes head and neck squamous cell carcinoma to 5-AZA-2'-deoxycytidine.
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Loss of the adhesion molecule CEACAM1 is associated with early biochemical recurrence in TMPRSS2:ERG fusion-positive prostate cancers.
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Low expression level of phosphatase and tensin homolog deleted on chromosome ten predicts poor prognosis in chronic lymphocytic leukemia.
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Low?intensity ultrasound enhances the antitumor effects of doxorubicin on hepatocellular carcinoma cells through the ROS?miR?21?PTEN axis.
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Lung neuroendocrine tumors: correlation of ubiquitinylation and sumoylation with nucleo-cytosolic partitioning of PTEN.
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Mammalian target of rapamycin inhibition as therapy for hematologic malignancies.
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Mannan-Conjugated Adenovirus Enhanced Gene Therapy Effects on Murine Hepatocellular Carcinoma Cells in Vitro and in Vivo.
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Mechanism of human PTEN localization revealed by heterologous expression in Dictyostelium.
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Mechanisms of Disease: the PI3K-Akt-PTEN signaling node--an intercept point for the control of angiogenesis in brain tumors.
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Mechanisms of Intrinsic Tumor Resistance to Immunotherapy.
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Mediastinal Germ Cell Tumor and Acute Megakaryoblastic Leukemia With Co-occurring KRAS Mutation and Complex Cytogenetics.
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Mesenchymal stem cell signaling in cancer progression.
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Metastasis suppressor protein 1 regulated by PTEN suppresses invasion, migration, and EMT of gastric carcinoma by inactivating PI3K/AKT signaling.
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Metastasis-associated Protein 1/Histone Deacetylase 4-Nucleosome Remodeling and Deacetylase Complex Regulates Phosphatase and Tensin Homolog Gene Expression and Function.
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Metastatic Chromophobe Renal Cell Carcinoma: Presence or Absence of Sarcomatoid Differentiation Determines Clinical Course and Treatment Outcomes.
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Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis.
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Methylation status of the PTEN gene in adenoid cystic carcinoma cells.
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Methylseleninic Acid Superactivates p53-Senescence Cancer Progression Barrier in Prostate Lesions of Pten-Knockout Mouse.
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Mgat5 and Pten interact to regulate cell growth and polarity.
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Mice lacking dystrophin or alpha sarcoglycan spontaneously develop embryonal rhabdomyosarcoma with cancer-associated p53 mutations and alternatively spliced or mutant Mdm2 transcripts.
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Microdissection-based allelotyping: a novel technique to determine the temporal sequence and biological aggressiveness of colorectal cancer.
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MicroRNA 26b promotes colorectal cancer metastasis by downregulating phosphatase and tensin homolog and wingless-type MMTV integration site family member 5A.
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MicroRNA-1297 contributes to the progression of human cervical carcinoma through PTEN.
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MicroRNA-144 promotes cell proliferation, migration and invasion in nasopharyngeal carcinoma through repression of PTEN.
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MicroRNA-152 Targets Phosphatase and Tensin Homolog to Inhibit Apoptosis and Promote Cell Migration of Nasopharyngeal Carcinoma Cells.
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microRNA-181a is associated with poor prognosis of colorectal cancer.
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MicroRNA-200b and microRNA-200c are up-regulated in PCOS granulosa cell and inhibit KGN cell proliferation via targeting PTEN.
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MicroRNA-200c Promotes Suppressive Potential of Myeloid-Derived Suppressor Cells by Modulating PTEN and FOG2 Expression.
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MicroRNA-205-5p is upregulated in myelodysplastic syndromes and induces cell proliferation via PTEN suppression.
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MicroRNA-21 could be a molecular marker to predict the recurrence of nonmuscle invasive bladder cancer.
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MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2).
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MicroRNA-21 Orchestrates High Glucose-induced Signals to TOR Complex 1, Resulting in Renal Cell Pathology in Diabetes.
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MicroRNA-21 Overexpression Contributes to Vestibular Schwannoma Cell Proliferation and Survival.
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MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer.
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MicroRNA-21 stimulates gastric cancer growth and invasion by inhibiting the tumor suppressor effects of programmed cell death protein 4 and phosphatase and tensin homolog.
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microRNA-21-mediated regulation of Sprouty2 protein expression enhances the cytotoxic effect of 5-fluorouracil and metformin in colon cancer cells.
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MicroRNA-22 promotes cell survival upon UV radiation by repressing PTEN.
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MicroRNA-382 induced by HIF-1? is an angiogenic miR targeting the tumor suppressor phosphatase and tensin homolog.
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MicroRNA-4286 promotes cell proliferation, migration, and invasion via PTEN regulation of the PI3K/Akt pathway in non-small cell lung cancer.
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MicroRNA-498 promotes proliferation and migration by targeting the tumor suppressor PTEN in breast cancer cells.
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MicroRNA-590-5p promotes cell survival in endometrioid endometrial cancer by suppressing tumor suppressor PTEN.
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MicroRNA-92 regulates cervical tumorigenesis and its expression is upregulated by human papillomavirus-16 E6 in cervical cancer cells.
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MicroRNA-92a promotes growth, metastasis, and chemoresistance in non-small cell lung cancer cells by targeting PTEN.
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MicroRNA?494 promotes the proliferation and migration of human glioma cancer cells through the protein kinase B/mechanistic target of rapamycin pathway by phosphatase and tensin homolog expression.
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MicroRNAs that regulate PTEN as potential biomarkers in colorectal cancer: a systematic review.
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Mining tissue microarray data to uncover combinations of biomarker expression patterns that improve intermediate staging and grading of clear cell renal cell cancer.
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MiR-106b-5p Inhibits Tumor Necrosis Factor-?-induced Apoptosis by Targeting Phosphatase and Tensin Homolog Deleted on Chromosome 10 in Vascular Endothelial Cells.
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MiR-132 promotes the proliferation, invasion and migration of human pancreatic carcinoma by inhibition of the tumor suppressor gene PTEN.
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miR-142 suppresses proliferation and induces apoptosis of osteosarcoma cells by upregulating Rb.
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MiR-19a regulates the cell growth and apoptosis of osteosarcoma stem cells by targeting PTEN.
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miR-21 Is Linked to Glioma Angiogenesis: A Co-Localization Study.
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miR-29b regulates migration of human breast cancer cells.
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miR-3 Encoded by Hepatitis B Virus Downregulates PTEN Protein Expression and Promotes Cell Proliferation.
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miR-494 promotes progression of retinoblastoma via PTEN through PI3K/AKT signaling pathway.
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miR-545 promoted enterovirus 71 replication via directly targeting phosphatase and tensin homolog and tumor necrosis factor receptor-associated factor 6.
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MiR-6838-5p facilitates the proliferation and invasion of renal cell carcinoma cells through inhibiting the DMTF1/ARF-p53 axis.
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miR-92a promotes tumor growth of osteosarcoma by targeting PTEN/AKT signaling pathway.
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miR?21?5p confers doxorubicin resistance in gastric cancer cells by targeting PTEN and TIMP3.
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miRNA-1297 induces cell proliferation by targeting phosphatase and tensin homolog in testicular germ cell tumor cells.
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miRNA?328 overexpression confers cisplatin resistance in non?small cell lung cancer via targeting of PTEN.
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Modeling genomic diversity and tumor dependency in malignant melanoma.
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Moesin-ezrin-radixin-like protein (merlin) mediates protein interacting with the carboxyl terminus-1 (PICT-1)-induced growth inhibition of glioblastoma cells in the nucleus.
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Molecular analysis of circulating tumor DNA from breast cancer patients before and after surgery and following adjuvant chemotherapy.
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Molecular association of functioning stroma with carcinoma cells in the ovary: A preliminary study.
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Molecular diagnostics of gliomas using next generation sequencing of a glioma-tailored gene panel.
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Molecular genetic analysis of non-astrocytic gliomas.
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Molecular genetic analysis of phosphatase and tensin homolog and p16 tumor suppressor genes in patients with malignant glioma.
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Molecular genetic defects in endometriosis.
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Molecular mutation characteristics of mismatch and homologous recombination repair genes in gastrointestinal cancer.
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Molecular pathways: intercellular PTEN and the potential of PTEN restoration therapy.
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Molecule-targeted agents in endometrial cancer.
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Monitoring the development of xenograft triple-negative breast cancer models using diffusion-weighted magnetic resonance imaging.
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Mouse PRL-2 and PRL-3, two potentially prenylated protein tyrosine phosphatases homologous to PRL-1.
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mTOR inhibitors reduce enteropathy, intestinal bleeding and colectomy rate in patients with juvenile polyposis of infancy with PTEN-BMPR1A deletion.
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mTOR, a Potential Target to Treat Autism Spectrum Disorder.
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Multi-focal sequencing of a diffuse intrinsic pontine glioma establishes PTEN loss as an early event.
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Multifaceted Regulation of PTEN Subcellular Distributions and Biological Functions.
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Multifocal demyelinating motor neuropathy and hamartoma syndrome associated with a de novo PTEN mutation.
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Multiple Intracranial Arteriovenous Fistulas in Cowden Syndrome.
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Multiple sclerotic fibromas of the skin: an important clue for the diagnosis of Cowden syndrome.
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Mutation analysis of PTEN/MMAC 1 in sporadic thyroid tumors.
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Mutation analysis of PTEN/MMAC1 in acute myeloid leukemia.
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Mutation analysis of the PTEN/MMAC1 gene in cancers of the digestive tract.
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Mutation analysis of the PTEN/MMAC1 gene in lung cancer.
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Mutation analysis of the putative tumor suppression gene PTEN/MMAC1 in sporadic breast cancer.
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Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in advanced gastric carcinomas.
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Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in cervical cancer.
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Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in hepatocellular carcinoma.
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Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in primary breast carcinomas.
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Mutation analysis of the putative tumor suppressor PTEN/MMAC1 in human ovarian cancer.
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Mutation and allelic loss of the PTEN/MMAC1 gene in primary and metastatic melanoma biopsies.
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Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems.
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Mutation of the PTEN gene in a human hepatic angiosarcoma.
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Mutation-positive and mutation-negative patients with Cowden and Bannayan-Riley-Ruvalcaba syndromes associated with distinct 10q haplotypes.
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Mutational abrogation of the PTEN/MMAC1 gene in gastrointestinal polyps in patients with Cowden disease.
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Mutational Analysis of the PTEN Gene and Its Effects in Esophageal Squamous Cell Carcinoma.
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Mutational analysis of the PTEN/MMAC1 gene in non-Hodgkin's lymphoma.
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Mutational analysis of the PTEN/MMAC1 gene in primary oesophageal squamous cell carcinomas.
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Mutational analysis of the PTEN/MMAC1 tumour suppressor gene in primary human malignant mesotheliomas.
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Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity.
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Mutations in the PI3K/PTEN/TSC2 pathway contribute to mammalian target of rapamycin activity and increased translation under hypoxic conditions.
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Mutations of phosphatase and tensin homolog deleted from chromosome 10 in canine hemangiosarcoma.
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Mutations of PTEN/MMAC1 in primary prostate cancers from Chinese patients.
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Myosin 1b Regulates Nuclear AKT Activation by Preventing Localization of PTEN in the Nucleus.
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Myristoylated alanine-rich C-kinase substrate effector domain phosphorylation regulates the growth and radiation sensitization of glioblastoma.
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NEDD4 promotes cell growth and migration via PTEN/PI3K/AKT signaling in hepatocellular carcinoma.
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Negative regulation of CXCR4-mediated chemotaxis by the lipid phosphatase activity of tumor suppressor PTEN.
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Neuroendocrine Tumor of the Pancreas as a Manifestation of Cowden Syndrome: A Case Report.
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New insights in the activity of voltage sensitive phosphatases.
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New Insights into Protein Kinase B/Akt Signaling: Role of Localized Akt Activation and Compartment-Specific Target Proteins for the Cellular Radiation Response.
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New insights into PTEN regulation mechanisms and its potential function in targeted therapies.
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New Treatment Opportunities in Phosphatase and Tensin Homolog (PTEN)-Deficient Tumors: Focus on PTEN/Focal Adhesion Kinase Pathway.
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Next-generation sequencing and clinical outcomes of patients with lung adenocarcinoma treated with stereotactic body radiotherapy.
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NHERF1/EBP50 controls morphogenesis of 3D colonic glands by stabilizing PTEN and ezrin-radixin-moesin proteins at the apical membrane.
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No association between phosphatase and tensin homolog genetic polymorphisms and colon cancer.
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Non-genomic loss of PTEN function in cancer: not in my genes.
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Non-Specific Blocking of miR-17-5p Guide Strand in Triple Negative Breast Cancer Cells by Amplifying Passenger Strand Activity.
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Novel approaches to inhibitor design for the p110? phosphoinositide 3-kinase.
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Novel inhibitors of the PI3K family.
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Novel insight into the function of tankyrase.
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Novel therapeutic roles of MC-4 in combination with everolimus against advanced renal cell carcinoma by dual targeting of Akt/pyruvate kinase muscle isozyme M2 and mechanistic target of rapamycin complex 1 pathways.
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Nuclear PTEN controls DNA repair and sensitivity to genotoxic stress.
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Nuclear PTEN deficiency causes microcephaly with decreased neuronal soma size and increased seizure susceptibility.
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Nuclear-cytoplasmic partitioning of phosphatase and tensin homologue deleted on chromosome 10 (PTEN) differentially regulates the cell cycle and apoptosis.
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NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations.
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Oncogenic activation of PI3K-AKT-mTOR signaling suppresses ferroptosis via SREBP-mediated lipogenesis.
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Oncogenic Smurf1 promotes PTEN wild-type glioblastoma growth by mediating PTEN ubiquitylation.
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OncomiRs: the discovery and progress of microRNAs in cancers.
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Oncophenotypic review and clinical correlates of phosphatase and tensin homolog on chromosome 10 hamartoma tumor syndrome.
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Optimal protocol for PTEN immunostaining; role of analytical and preanalytical variables in PTEN staining in normal and neoplastic endometrial, breast, and prostatic tissues.
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Oral manifestations of phosphatase and tensin homolog hamartoma tumor syndrome: a report of three cases.
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Ordered phosphorylation events in two independent cascades of the PTEN C-tail revealed by NMR.
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Over expression of PTEN induces apoptosis and prevents cell proliferation in breast cancer cells.
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Over-expression of DJ-1 attenuates effects of curcumin on colorectal cancer cell proliferation and apoptosis.
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Over-Expression of miR-21 and Lower PTEN Levels in Wilms' Tumor with Aggressive Behavior.
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Overexpression of AKT2/protein kinase Bbeta leads to up-regulation of beta1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells.
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Overexpression of DJ-1 and HSP90?, and loss of PTEN associated with invasive urothelial carcinoma of urinary bladder: Possible prognostic markers.
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Overexpression of microRNA-30a-5p inhibits liver cancer cell proliferation and induces apoptosis by targeting MTDH/PTEN/AKT pathway.
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Overexpression of PTEN in ovarian cancer cells suppresses i.p. dissemination and extends survival in mice.
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Overexpression of PTEN Induces Cell Growth Arrest and Apoptosis in Human Breast Cancer ZR-75-1 Cells.
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Overexpression of PTEN suppresses non-small-cell lung carcinoma metastasis through inhibition of integrin ?V?6 signaling.
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Overexpression of the tumor suppressor gene phosphatase and tensin homologue partially inhibits wnt-1-induced mammary tumorigenesis.
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Overexpression of UBR5 promotes tumor growth in gallbladder cancer via PTEN/PI3K/Akt signal pathway.
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p53 and PTEN/MMAC1 mutational analysis of the small-intestinal cancer.
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p53 down-regulates phosphatase and tensin homologue deleted on chromosome 10 protein stability partially through caspase-mediated degradation in cells with proteasome dysfunction.
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Pancreatic endocrine tumors: expression profiling evidences a role for AKT-mTOR pathway.
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Parkes Weber syndrome, vein of Galen aneurysmal malformation, and other fast-flow vascular anomalies are caused by RASA1 mutations.
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Pathogenic and likely pathogenic variants in PALB2, CHEK2, and other known breast cancer susceptibility genes among 1054 BRCA-negative Hispanics with breast cancer.
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Pathogenicity and virulence of Japanese encephalitis virus: Neuroinflammation and neuronal cell damage.
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Pathological effects of prostate cancer correlate with neuroendocrine differentiation and PTEN expression after bicalutamide monotherapy.
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Pathological integrin signaling enhances proliferation of primary lung fibroblasts from patients with idiopathic pulmonary fibrosis.
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Pectolinarigenin inhibits non?small cell lung cancer progression by regulating the PTEN/PI3K/AKT signaling pathway.
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Peroxisome proliferator-activated receptor-? inhibits pancreatic cancer cell invasion and metastasis via regulating MMP-2 expression through PTEN.
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Persistent inflammation leads to proliferative neoplasia and loss of smooth muscle cells in a prostate tumor model.
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Perspectives on the role of PTEN in diabetic nephropathy: an update.
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Pharmacogenomic profiling of the PI3K/PTEN pathway in sporadic breast cancer.
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Pharmacological targeting of the integrated protein kinase B, phosphatase and tensin homolog deleted on chromosome 10, and transforming growth factor-beta pathways in prostate cancer.
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Phase 2 trial of single-agent everolimus in chemotherapy-naive patients with castration-resistant prostate cancer (SAKK 08/08).
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Phase II study of carboplatin and erlotinib (Tarceva, OSI-774) in patients with recurrent glioblastoma.
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Phase II study of erlotinib in patients with malignant pleural mesothelioma: a Southwest Oncology Group Study.
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Phase II study of erlotinib plus temozolomide during and after radiation therapy in patients with newly diagnosed glioblastoma multiforme or gliosarcoma.
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Phase II study of everolimus in refractory testicular germ cell tumors.
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Phase II Study of Temsirolimus in Women With Recurrent or Metastatic Endometrial Cancer: A Trial of the NCIC Clinical Trials Group.
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Phosphatase and tensin homolog (PTEN) expression on oncologic outcome in renal cell carcinoma: A systematic review and meta-analysis.
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Phosphatase and Tensin Homolog (PTEN) Gene Mutations and Autism: Literature Review and a Case Report of a Patient With Cowden Syndrome, Autistic Disorder and Epilepsy.
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Phosphatase and tensin homolog (PTEN) is down-regulated in human NK/T-cell lymphoma and corrects with clinical outcomes.
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Phosphatase and Tensin Homolog (PTEN) Represses Colon Cancer Progression through Inhibiting Paxillin Transcription via PI3K/AKT/NF-?B Pathway.
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Phosphatase and tensin homolog (PTEN) suppresses triacylglycerol accumulation and monounsaturated fatty acid synthesis in goat mammary epithelial cells.
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Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) and PH domain and leucine-rich repeat phosphatase cross-talk (PHLPP) in cancer cells and in transforming growth factor ?-activated stem cells.
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Phosphatase and tensin homolog deleted on chromosome 10 contributes to phenotype transformation of fibroblasts in idiopathic pulmonary fibrosis via multiple pathways.
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Phosphatase and tensin homolog deleted on chromosome 10 degradation induced by NEDD4 promotes acquired erlotinib resistance in non-small-cell lung cancer.
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Phosphatase and tensin homolog deleted on chromosome 10 regulates sensory cell proliferation and differentiation of hair bundles in the mammalian cochlea.
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Phosphatase and tensin homolog deletion enhances neurite outgrowth during neural stem cell differentiation.
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Phosphatase and Tensin Homolog Hamartoma Tumor Syndrome: A Case Report.
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Phosphatase and Tensin Homolog in Non-neoplastic Digestive Disease: More Than Just Tumor Suppressor.
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Phosphatase and Tensin Homolog Is a Potential Target for Ovarian Cancer Sensitization to Cytotoxic Agents.
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Phosphatase and tensin homolog overexpression decreases proliferation and invasion and increases apoptosis in oral squamous cell carcinoma cells.
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Phosphatase and tensin homolog protein may be linked to lymph node metastasis and tumor node metastasis staging in nonsmall cell lung cancer.
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Phosphatase and tensin homolog regulates stability and activity of EphB1 receptor.
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Phosphatase and tensin homologue deleted on chromosome 10 deficiency accelerates tumor induction in a mouse model of ErbB-2 mammary tumorigenesis.
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Phosphatase and tensin homologue deleted on chromosome 10.
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Phosphatase and tensin homologue deleted on chromosome 10: extending its PTENtacles.
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Phosphatase PTEN in neuronal injury and brain disorders.
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Phosphatidylinositol 3-kinase inhibitors: promising drug candidates for cancer therapy.
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Phosphatidylinositol 3-kinase mediates bronchioalveolar stem cell expansion in mouse models of oncogenic K-ras-induced lung cancer.
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Phosphatidylinositol 3-kinase regulatory subunit 1 and phosphatase and tensin homolog as therapeutic targets in breast cancer.
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Phosphoinositide 3-Kinase/Akt Signaling and Redox Metabolism in Cancer.
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Phosphoinositide phosphatases in a network of signalling reactions.
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Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes.
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Phospholipase D prevents etoposide-induced apoptosis by inhibiting the expression of early growth response-1 and phosphatase and tensin homologue deleted on chromosome 10.
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Phospholipid-binding Sites of Phosphatase and Tensin Homolog (PTEN): EXPLORING THE MECHANISM OF PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE ACTIVATION.
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Phosphorylated Akt Expression as a Favorable Prognostic Factor for Patients Undergoing Curative Resection and Adjuvant Chemoradiotherapy for Proximal Extrahepatic Bile Duct Cancer.
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Phosphorylated galectin-3 mediates tumor necrosis factor-related apoptosis-inducing ligand signaling by regulating phosphatase and tensin homologue deleted on chromosome 10 in human breast carcinoma cells.
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Phosphorylated insulin-like growth factor-1 receptor expression predicts poor prognosis of Chinese patients with gastric cancer.
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Phosphorylation of phosphatase and tensin homolog induced by
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Phosphorylation of PTEN (phosphatase and tensin homologue deleted on chromosome ten) protein is enhanced in human fibromyomatous uteri.
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Phosphorylation of PTEN at STT motif is associated with DNA damage response.
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Phosphorylation-regulated cleavage of the tumor suppressor PTEN by caspase-3: implications for the control of protein stability and PTEN-protein interactions.
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Photochemical internalization-mediated nonviral gene transfection: polyamine core-shell nanoparticles as gene carrier.
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PI(3)king apart PTEN's role in cancer.
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PI3K inhibition enhances the anti-tumor effect of eribulin in triple negative breast cancer.
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PI3K isoform dependence of PTEN-deficient tumors can be altered by the genetic context.
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Piceatannol suppresses proliferation and induces apoptosis by regulation of the microRNA?21/phosphatase and tensin homolog/protein kinase B signaling pathway in osteosarcoma cells.
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PIK3CA and PTEN mutations in adenoid cystic carcinoma of the breast metastatic to kidney.
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PIK3CA mutations in endometrial carcinomas in Chinese women: phosphatidylinositol 3'-kinase pathway alterations might be associated with favorable prognosis.
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Pilocytic astrocytoma presenting as primary diffuse leptomeningeal gliomatosis: report of a unique case and review of the literature.
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Pivotal role of Pten in the balance between proliferation and differentiation of hematopoietic stem cells in zebrafish.
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Planarian PTEN homologs regulate stem cells and regeneration through TOR signaling.
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Pleckstrin homology domain-interacting protein (PHIP) as a marker and mediator of melanoma metastasis.
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Point mutation and homozygous deletion of PTEN/MMAC1 in primary bladder cancers.
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Poly(ADP-ribose) polymerase inhibition as a model for synthetic lethality in developing radiation oncology targets.
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Poly-ADP ribosylation of PTEN by tankyrases promotes PTEN degradation and tumor growth.
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Possible biomarkers for predicting lymph node metastasis of esophageal squamous cell carcinoma: a review.
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Posttranslational Regulation and Conformational Plasticity of PTEN.
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Posttranslational regulation of phosphatase and tensin homolog (PTEN) and its functional impact on cancer behaviors.
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Potential prognostic value of heat-shock protein 90 in the presence of phosphatidylinositol-3-kinase overexpression or loss of PTEN, in invasive breast cancers.
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Potentiation of Inflammatory CXCL8 Signalling Sustains Cell Survival in PTEN-deficient Prostate Carcinoma.
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Power of PTEN/AKT: Molecular switch between tumor suppressors and oncogenes.
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PPARgamma, PTEN, and the Fight against Cancer.
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Predicting the combined effect of multiple genetic variants.
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Predictive factors of the tumor immunological microenvironment for long-term follow-up in early stage breast cancer.
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Preservation of GABAA receptor function by PTEN inhibition protects against neuronal death in ischemic stroke.
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Prevalence and clinical/molecular characteristics of PTEN mutations in Turkish children with autism spectrum disorders and macrocephaly.
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Preventive effects of AdR-siPTEN through the regulation of NMDA receptor NR2B subunit in trigeminal ganglia of migraine rats.
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PREX2 promotes the proliferation, invasion and migration of pancreatic cancer cells by modulating the PI3K signaling pathway.
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PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis.
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Proapoptotic kinase MST2 coordinates signaling crosstalk between RASSF1A, Raf-1, and Akt.
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Prognosis of patients with multifocal glioblastoma: a case-control study.
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Prognostic and Predictive Implications of PTEN in Breast Cancer: Unfulfilled Promises but Intriguing Perspectives.
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Prognostic tissue biomarker exploration for patients with metastatic renal cell carcinoma receiving vascular endothelial growth factor receptor tyrosine kinase inhibitors.
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Promoter Methylation of PTEN Is a Significant Prognostic Factor in Melanoma Survival.
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Promoter region methylation and loss of protein expression of PTEN and significance in cervical cancer.
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Promotion of PTEN on apoptosis through PI3K/Akt signal in vascular smooth muscle cells of mice model of coronary heart disease.
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Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC.
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Protein phosphatase 5 and the tumor suppressor P53 down-regulate each other's activities in mice.
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Protein tyrosine phosphatases in cancer: friends and foes!
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Proteome profile changes that are differentially regulated by lipid and protein phosphatase activities of tumor suppressor PTEN in PTEN-expressing U-87 MG human glioblastoma cells.
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Proteomic and transcriptomic profiling of Pten gene-knockout mouse model of prostate cancer.
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PTEN activation through K163 acetylation by inhibiting HDAC6 contributes to tumour inhibition.
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PTEN Activity Defines an Axis for Plasticity at Cortico-Amygdala Synapses and Influences Social Behavior.
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PTEN Alterations and Their Role in Cancer Management: Are We Making Headway on Precision Medicine?
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PTEN alterations of the stromal cells characterise an aggressive subpopulation of pancreatic cancer with enhanced metastatic potential.
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PTEN and ERG detection in multiparametric magnetic resonance imaging/ultrasound fusion targeted prostate biopsy compared to systematic biopsy.
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PTEN and ERG expression in MRI-ultrasound guided fusion biopsy correlated with radical prostatectomy findings in men with prostate cancer.
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PTEN and hTERT gene expression and the correlation with human hepatocellular carcinoma.
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PTEN and Ki67 expression is associated with clinicopathologic features of non-small cell lung cancer.
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PTEN and miR-26b: Promising prognostic biomarkers in initiation and progression of Oral Squamous Cell Carcinoma.
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PTEN and NF1 inactivation in Schwann cells produces a severe phenotype in the peripheral nervous system that promotes the development and malignant progression of peripheral nerve sheath tumors.
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PTEN and p16 genes as epigenetic biomarkers in oral squamous cell carcinoma (OSCC): a study on south Indian population.
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PTEN and p53 cross-regulation induced by soy isoflavone genistein promotes mammary epithelial cell cycle arrest and lobuloalveolar differentiation.
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PTEN and TRAIL genes loaded zein nanoparticles as potential therapy for hepatocellular carcinoma.
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PTEN as a Prognostic/Predictive Biomarker in Cancer: An Unfulfilled Promise?
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PTEN as a Unique Promising Therapeutic Target for Occupational Asthma.
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PTEN breast cancer susceptibility: a matter of dose.
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PTEN ceRNA networks in human cancer.
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PTEN counteracts FBXL2 to promote IP3R3- and Ca(2+)-mediated apoptosis limiting tumour growth.
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PTEN decreases in vivo vascularization of experimental gliomas in spite of proangiogenic stimuli.
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PTEN deficiency is fully penetrant for prostate adenocarcinoma in C57BL/6 mice via mTOR-dependent growth.
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PTEN deficiency sensitizes endometrioid endometrial cancer to compound PARP-PI3K inhibition but not PARP inhibition as monotherapy.
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PTEN degradation after ischemic stroke: a double-edged sword.
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PTEN deletion drives aberrations of DNA methylome and transcriptome in different stages of prostate cancer.
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PTEN down-regulation by unsaturated fatty acids triggers hepatic steatosis via an NF-kappaBp65/mTOR-dependent mechanism.
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PTEN Down-Regulation Promotes ?-Oxidation to Fuel Hypertrophic Liver Growth After Hepatectomy in Mice.
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PTEN downregulates WD repeat?containing protein 66 in salivary adenoid cystic carcinoma.
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PTEN enhances G2/M arrest in etoposide-treated MCF?7 cells through activation of the ATM pathway.
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PTEN expression and mutation in colorectal carcinomas.
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PTEN Expression as a Complementary Biomarker for Mismatch Repair Testing in Breast Cancer.
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PTEN expression by an oncolytic herpesvirus directs T-cell mediated tumor clearance.
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PTEN expression in endothelial cells is down-regulated by uPAR to promote angiogenesis.
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PTEN expression in melanoma: relationship with patient survival, Bcl-2 expression, and proliferation.
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PTEN expression in normal skin, acquired melanocytic nevi, and cutaneous melanoma.
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PTEN expression in patients with carcinoma of the cervix and its association with p53, Ki-67 and CD31.
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PTEN expression in U251 glioma cells enhances their sensitivity to ionizing radiation by suppressing DNA repair capacity.
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PTEN expression is a prognostic marker for patients with non-small cell lung cancer: a systematic review and meta-analysis of the literature.
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PTEN expression is a strong predictor of survival in mesothelioma patients.
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PTEN Function at the Interface between Cancer and Tumor Microenvironment: Implications for Response to Immunotherapy.
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PTEN function: the long and the short of it.
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PTEN functions as a melanoma tumor suppressor by promoting host immune response.
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PTEN gene polymorphisms and susceptibility to oral squamous cell carcinoma in a Chinese Han population.
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PTEN gene: a model for genetic diseases in dermatology.
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PTEN Hamartoma Tumor Syndrome: A Clinical Overview.
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PTEN Hamartoma Tumor Syndrome: Clinical Risk Assessment and Management Protocol.
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PTEN hamartomatous tumor syndromes (PHTS): rare syndromes with great relevance to common cancers and targeted drug development.
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Pten Haplodeficiency Accelerates Liver Tumor Growth in miR-122a-Null Mice via Expansion of Periportal Hepatocyte-Like Cells.
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PTEN in Autism and Neurodevelopmental Disorders.
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PTEN in DNA damage repair.
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PTEN in Hereditary and Sporadic Cancer.
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PTEN in kidney cancer: A review and meta-analysis.
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PTEN in Lung Cancer: Dealing with the Problem, Building on New Knowledge and Turning the Game Around.
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PTEN in osteosarcoma: Recent advances and the therapeutic potential.
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PTEN in the haematopoietic system and its therapeutic indications.
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PTEN in the Stroma.
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Pten inactivation accelerates oncogenic K-ras-initiated tumorigenesis in a mouse model of lung cancer.
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PTEN induces apoptosis and cavitation via HIF-2-dependent Bnip3 upregulation during epithelial lumen formation.
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PTEN influences insulin and lipid metabolism in bovine hepatocytes in vitro.
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PTEN Inhibition Ameliorates Muscle Degeneration and Improves Muscle Function in a Mouse Model of Duchenne Muscular Dystrophy.
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PTEN inhibition and axon regeneration and neural repair.
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PTEN inhibitor VO-OHpic attenuates GC-associated endothelial progenitor cell dysfunction and osteonecrosis of the femoral head via activating Nrf2 signaling and inhibiting mitochondrial apoptosis pathway.
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PTEN inhibits non-small cell lung cancer cell growth by promoting G0/G1 arrest and cell apoptosis.
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PTEN inhibits the invasion and metastasis of gastric cancer via downregulation of FAK expression.
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PTEN insufficiency modulates ER+ breast cancer cell cycle progression and increases cell growth in vitro and in vivo.
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PTEN interacts with the transcription machinery on chromatin and regulates RNA polymerase II-mediated transcription.
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PTEN is a negative regulator of STAT3 activation in human papillomavirus-infected cells.
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PTEN is a tumor suppressor in CML stem cells and BCR-ABL-induced leukemias in mice.
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PTEN is required for the migration and invasion of Ras-transformed MDCK cells.
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PTEN Lipid Phosphatase Activity and Proper Subcellular Localization Are Necessary and Sufficient for Down-Regulating AKT Phosphorylation in the Nucleus in Cowden Syndrome.
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PTEN lipid phosphatase inactivation links the hippo and PI3K/Akt pathways to induce gastric tumorigenesis.
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PTEN loss and HOXA10 expression are associated with ovarian endometrioid adenocarcinoma differentiation and progression.
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PTEN loss correlates with T cell exclusion across human cancers.
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PTEN loss defines a PI3K/AKT pathway-dependent germinal center subtype of diffuse large B-cell lymphoma.
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PTEN losses exhibit heterogeneity in multifocal prostatic adenocarcinoma and are associated with higher Gleason grade.
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PTEN modulates EGFR late endocytic trafficking and degradation by dephosphorylating Rab7.
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PTEN Mouse Models of Cancer Initiation and Progression.
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PTEN mutation spectrum in breast cancers and breast hyperplasia.
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PTEN mutation, loss of heterozygosity, promoter methylation and expression in colorectal carcinoma: Two hits on the gene?
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PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry.
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PTEN on Chromosome 10 Is Phosphorylated in Primary Effusion Lymphoma and Kaposi's Sarcoma.
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PTEN opposes negative selection and enables oncogenic transformation of pre-B cells.
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PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability.
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PTEN Promoter Methylation in Sporadic Thyroid Carcinomas.
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PTEN promotes intervertebral disc degeneration by regulating nucleus pulposus cell behaviors.
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PTEN protects kidney against acute kidney injury by alleviating apoptosis and promoting autophagy via regulating HIF1-? and mTOR through PI3K/Akt pathway.
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PTEN Protein Loss and Clinical Outcome from Castration-resistant Prostate Cancer Treated with Abiraterone Acetate.
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PTEN Protein Loss and Loss-of-Function Mutations in Gastric Cancers: The Relationship with Microsatellite Instability, EBV, HER2, and PD-L1 Expression.
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PTEN Protein Phosphatase Activity Correlates with Control of Gene Expression and Invasion, a Tumor-Suppressing Phenotype, But Not with AKT Activity.
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PTEN regulates adipose progenitor cell growth, differentiation, and replicative aging.
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PTEN regulates cilia through Dishevelled.
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Pten regulates homeostasis and inflammation-induced migration of myelocytes in zebrafish.
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PTEN regulates matrix synthesis in adult human chondrocytes under oxidative stress.
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PTEN Regulates PDGF Ligand Switch for ?-PDGFR Signaling in Prostate Cancer.
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PTEN regulation of ERK1/2 signaling in cancer.
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PTEN regulation of neural development and CNS stem cells.
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PTEN sensitizes MDA-MB-468 cells to inhibition of MEK/Erk signaling for the blockade of cell proliferation.
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PTEN sequence analysis in endometrial hyperplasia and endometrial carcinoma in Slovak women.
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PTEN signaling in brain: neuropathology and tumorigenesis.
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PTEN signaling pathways in melanoma.
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PTEN status switches cell fate between premature senescence and apoptosis in glioma exposed to ionizing radiation.
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PTEN suppresses breast cancer cell growth by phosphatase activity-dependent G1 arrest followed by cell death.
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PTEN suppresses SPARC-induced pMAPKAPK2 and inhibits SPARC-induced Ser78 HSP27 phosphorylation in glioma.
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PTEN suppresses the oncogenic function of AIB1 through decreasing its protein stability via mechanism involving Fbw7 alpha.
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PTEN tumor suppressor plays less prognostic role than P53 tumor suppressor in diffuse large B-cell lymphoma.
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PTEN Tumor-Suppressor: The Dam of Stemness in Cancer.
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PTEN's regulation of VEGF and VEGFR1 expression and its clinical significance in myeloid leukemia.
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PTEN, NHERF1 and PHLPP form a tumor suppressor network that is disabled in glioblastoma.
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PTEN-5-HT2C coupling: a new target for treating drug addiction.
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PTEN-deficient cancers depend on PIK3CB.
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PTEN-deficient intestinal stem cells initiate intestinal polyposis.
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PTEN-Dependent Stabilization of MTSS1 Inhibits Metastatic Phenotype in Pancreatic Ductal Adenocarcinoma.
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PTEN-L promotes type I interferon responses and antiviral immunity.
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PTEN-opathies: from biological insights to evidence-based precision medicine.
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PTEN/MMAC1 enhances the growth inhibition by anticancer drugs with downregulation of IGF-II expression in gastric cancer cells.
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PTEN/MMAC1 expression in esophageal squamous cell carcinomas.
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PTEN/MMAC1 expression in melanoma resection specimens.
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PTEN/MMAC1 gene mutation is a rare event in soft tissue sarcomas without specific balanced translocations.
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PTEN/MMAC1 in malignant melanoma and its importance for tumor progression.
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PTEN/MMAC1 is infrequently mutated in pT2 and pT3 carcinomas of the prostate.
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PTEN/MMAC1 mutations and EGFR amplification in glioblastomas.
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PTEN/MMAC1 mutations correlate inversely with an altered p53 tumor suppressor gene in gynecologic tumors.
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PTEN/MMAC1 mutations identified in small cell, but not in non-small cell lung cancers.
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PTEN/MMAC1 mutations in endometrial cancers.
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PTEN/MMAC1 mutations in hepatocellular carcinomas.
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PTEN/MMAC1 mutations in hepatocellular carcinomas: somatic inactivation of both alleles in tumors.
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PTEN/MMAC1 mutations in primary glioblastomas and short-term cultures of malignant gliomas.
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PTEN/MMAC1/TEP1 in signal transduction and tumorigenesis.
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PTEN/PI3K/Akt/VEGF signaling and the cross talk to KRIT1, CCM2, and PDCD10 proteins in cerebral cavernous malformations.
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PTEN/PTENP1: 'Regulating the regulator of RTK-dependent PI3K/Akt signalling', new targets for cancer therapy.
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PTEN: A crucial mediator of mitochondria-dependent apoptosis.
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PTEN: a new guardian of the genome.
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PTEN: its deregulation and tumorigenesis.
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PTEN: What we know of the function and regulation of this onco-suppressor factor in bladder cancer?
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PTEN? regulates endocytosis and modulates olfactory function.
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Pulmonary atypical carcinoid in a patient with Cowden syndrome.
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Putting the rap on Akt.
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Quantitative MRI establishes the efficacy of PI3K inhibitor (GDC-0941) multi-treatments in PTEN-deficient mice lymphoma.
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Racial Disparities in the Molecular Landscape of Cancer.
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Radiation-resistant cancer stem-like cell properties are regulated by PTEN through the activity of nuclear ?-catenin in nasopharyngeal carcinoma.
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Radiation/paclitaxel treatment of p53-abnormal non-small cell lung cancer xenograft tumor and associated mechanism.
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RANKL blockade prevents and treats aggressive osteosarcomas.
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Rapamycin promotes autophagy cell death of Kaposi's sarcoma cells through P75NTR activation.
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Rapid Detection of Dynamic PTEN Regulation in Living Cells Using Intramolecular BRET.
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Rapid estrogen signaling negatively regulates PTEN activity through phosphorylation in endometrial cancer cells.
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Reactivation of the tumor suppressor PTEN by mRNA nanoparticles enhances antitumor immunity in preclinical models.
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Reactive Oxygen Species, Superoxide Dimutases, and PTEN-p53-AKT-MDM2 Signaling Loop Network in Mesenchymal Stem/Stromal Cells Regulation.
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Reassembly of Excitable Domains after CNS Axon Regeneration.
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Redox Regulation of PTEN by Peroxiredoxins.
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Redox regulation of the tumor suppressor PTEN by the thioredoxin system and cumene hydroperoxide.
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Redox regulation of tumor suppressor PTEN in cancer and aging (Review).
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Reduced progression of endometrial hyperplasia with oral mTOR inhibition in the Pten heterozygote murine model.
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Reduced PTEN expression and overexpression of miR-17-5p, -19a-3p, -19b-3p, -21-5p, -130b-3p, -221-3p and -222-3p by glioblastoma stem-like cells following irradiation.
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Reduced PTEN protein expression and its prognostic implications in canine and feline mammary tumours.
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Regulating tumor suppressor genes: post-translational modifications.
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Regulation of cancer metabolism by oncogenes and tumor suppressors.
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Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway.
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Regulation of Hematopoietic Cell Development and Function Through Phosphoinositides.
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Regulation of mammary stem/progenitor cells by PTEN/Akt/beta-catenin signaling.
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Regulation of PTEN expression by noncoding RNAs.
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Regulation of PTEN expression in intestinal epithelial cells by c-Jun NH2-terminal kinase activation and nuclear factor-kappaB inhibition.
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Regulation of PTEN expression in neuronal apoptosis.
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Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11.
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Regulation of the PTEN phosphatase.
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Regulation of the tumor suppressor PTEN by natural anticancer compounds.
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Regulatory role of microRNAs on PTEN signaling.
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Relationship between down-regulation of HIC1 and PTEN genes and dysfunction of pancreatic islet cells in diabetic rats.
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Relative reciprocity of NRAS and PTEN/MMAC1 alterations in cutaneous melanoma cell lines.
Neoplasms
Repression of mammosphere formation of human breast cancer cells by soy isoflavone genistein and blueberry polyphenolic acids suggests diet-mediated targeting of cancer stem-like/progenitor cells.
Neoplasms
Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240.
Neoplasms
Restoration of PTEN activity decreases metastases in an orthotopic model of colon cancer.
Neoplasms
Restoration of tumour-growth suppression in vivo via systemic nanoparticle-mediated delivery of PTEN mRNA.
Neoplasms
Restoring E-cadherin-mediated cell-cell adhesion increases PTEN protein level and stability in human breast carcinoma cells.
Neoplasms
Resveratrol Potentiates Growth Inhibitory Effects of Rapamycin in PTEN-deficient Lipoma Cells by Suppressing p70S6 Kinase Activity.
Neoplasms
Retinal astrocytoma in a young male with PTEN hamartoma tumor syndrome.
Neoplasms
Revisiting the Warburg effect: historical dogma versus current understanding.
Neoplasms
Ribosomal DNA copy number loss and sequence variation in cancer.
Neoplasms
RNA-binding protein RBM38 inhibits colorectal cancer progression by partly and competitively binding to PTEN 3'UTR with miR-92a-3p.
Neoplasms
Role and mechanism of PTEN in adiponectin-induced osteogenesis in human bone marrow mesenchymal stem cells.
Neoplasms
Role of phosphatase and tensin homolog in the development of the mammalian auditory system.
Neoplasms
Role of PTEN in Basal Cell Derived Lung Carcinogenesis.
Neoplasms
Role of PTEN in cholera toxin-induced SWO?38 glioma cell differentiation.
Neoplasms
Role of PTEN in Oxidative Stress and DNA Damage in the Liver of Whole-Body Pten Haplodeficient Mice.
Neoplasms
Role of Rap1B and Tumor Suppressor PTEN in the Negative Regulation of Lysophosphatidic Acid-induced Migration by Isoproterenol in Glioma Cells.
Neoplasms
Role of the tumor suppressor PTEN in antioxidant responsive element-mediated transcription and associated histone modifications.
Neoplasms
Role of tumor suppressor molecules in genomic perturbations and damaged DNA repair involved in the pathogenesis of cancer and neurodegeneration (Review).
Neoplasms
Role of tumor suppressor PTEN in tumor necrosis factor alpha-induced inhibition of insulin signaling in murine skeletal muscle C2C12 cells.
Neoplasms
Roles of phosphatase and tensin homolog in skeletal muscle.
Neoplasms
Roles of Polo-like kinase 3 in suppressing tumor angiogenesis.
Neoplasms
ROS enhances CXCR4-mediated functions through inactivation of PTEN in prostate cancer cells.
Neoplasms
RSRC1 suppresses gastric cancer cell proliferation and migration by regulating PTEN expression.
Neoplasms
Saccharomyces cerevisiae-like 1 overexpression is frequent in prostate cancer and has markedly different effects in Ets-related gene fusion-positive and fusion-negative cancers.
Neoplasms
Saturated Fatty Acid-induced cytotoxicity in liver cells does not involve phosphatase and tensin homologue deleted on chromosome 10.
Neoplasms
Screening for germline phosphatase and tensin homolog-mutations in suspected Cowden syndrome and Cowden syndrome-like families among uterine cancer patients.
Neoplasms
Secretory lipophilins: a tale of two species.
Neoplasms
Selective targeting of radiation-resistant tumor-initiating cells.
Neoplasms
Sequence-Dependent Synergistic Inhibition of Human Glioma Cell Lines by Combined Temozolomide and miR-21 Inhibitor Gene Therapy.
Neoplasms
Sequencing the full-length of the phosphatase and tensin homolog (PTEN) gene in hepatocellular carcinoma (HCC) using the 454 GS20 and Illumina GA DNA sequencing platforms.
Neoplasms
Serum Biomarkers for Racial Disparities in Breast Cancer Progression.
Neoplasms
Signals Controlling Un-Differentiated States in Embryonic Stem and Cancer Cells: Role of the Phosphatidylinositol 3' Kinase Pathway.
Neoplasms
Significance of microRNA 21 in gastric cancer.
Neoplasms
Silencing miRNA-1297 suppresses the invasion and migration of prostate cancer cells via targeting modulation of PTEN and blocking of the AKT/ERK pathway.
Neoplasms
Silencing of PTEN inhibits the oxidative stress damage and hippocampal cell apoptosis induced by Sevoflurane through activating MEK1/ERK signaling pathway in infant rats.
Neoplasms
Simultaneous loss of the DLC1 and PTEN tumor suppressors enhances breast cancer cell migration.
Neoplasms
Simvastatin and metformin inhibit cell growth in hepatitis C virus infected cells via mTOR increasing PTEN and autophagy.
Neoplasms
Simvastatin induces apoptosis in PTEN?haploinsufficient lipoma cells.
Neoplasms
Single nucleotide polymorphism in PTEN-Long gene: A risk factor in chronic myeloid leukemia.
Neoplasms
Single nucleotide polymorphisms rs701848 and rs2735343 in PTEN increases cancer risks in an Asian population.
Neoplasms
Single-cell profiling of pediatric T-cell acute lymphoblastic leukemia: Impact of PTEN exon 7 mutation on PI3K/Akt and JAK-STAT signaling pathways.
Neoplasms
SIRT4 regulates PTEN stability through IDE in response to cellular stresses.
Neoplasms
SLFN5 influences proliferation and apoptosis by upregulating PTEN transcription via ZEB1 and inhibits the purine metabolic pathway in breast cancer.
Neoplasms
Small in Size, but Large in Action: microRNAs as Potential Modulators of PTEN in Breast and Lung Cancers.
Neoplasms
Solubility enhancement and targeted delivery of a potent anticancer flavonoid analogue to cancer cells using ligand decorated dendrimer nano-architectures.
Neoplasms
Somatic deletion mapping on chromosome 10 and sequence analysis of PTEN/MMAC1 point to the 10q25-26 region as the primary target in low-grade and high-grade gliomas.
Neoplasms
Somatic Host Cell Alterations in HPV Carcinogenesis.
Neoplasms
Somatic mutation and homozygous deletion of PTEN/MMAC1 gene of 10q23 in renal cell carcinoma.
Neoplasms
Somatic mutation of PTEN in bladder carcinoma.
Neoplasms
Somatic mutation of the PTEN/MMAC1 gene in breast cancers with microsatellite instability.
Neoplasms
Somatic mutations in PIK3CA and activation of AKT in intraductal tubulopapillary neoplasms of the pancreas.
Neoplasms
Somatic mutations of the PTEN/MMAC1 gene in fifteen Japanese endometrial cancers: evidence for inactivation of both alleles.
Neoplasms
Somatic mutations of the PTEN/NMAC1 gene associated with frequent chromosomal loss detected using comparative genomic hybridization in endometrial cancer.
Neoplasms
Special bioactive compounds and functional foods may exhibit neuroprotective effects in patients with dementia (Review).
Neoplasms
Sprouty1 induces a senescence-associated secretory phenotype by regulating NF?B activity: implications for tumorigenesis.
Neoplasms
Stable tumor vessel normalization with pO2 increase and endothelial PTEN activation by inositol trispyrophosphate brings novel tumor treatment.
Neoplasms
STAT3-iNOS Signaling Mediates EGFRvIII-Induced Glial Proliferation and Transformation.
Neoplasms
Steroid hormone intervenes in the endometrial tumorigenesis of pten ablation.
Neoplasms
Stromal PTEN inhibits the expansion of mammary epithelial stem cells through Jagged-1.
Neoplasms
Structural Mechanisms of PTEN Regulation.
Neoplasms
Structural mutation analysis of PTEN and its genotype-phenotype correlations in endometriosis and cancer.
Neoplasms
Structure guided optimization of a fragment hit to imidazopyridine inhibitors of PI3K.
Neoplasms
Studying the Oncosuppressive Functions of PTENP1 as a ceRNA.
Neoplasms
SUMO, PTEN and Tumor Suppression.
Neoplasms
SUMO1 modification of PTEN regulates tumorigenesis by controlling its association with the plasma membrane.
Neoplasms
Suppression of planar cell polarity signaling and migration in glioblastoma by Nrdp1-mediated Dvl polyubiquitination.
Neoplasms
Suppression of PTEN Expression Is Essential for Antiapoptosis and Cellular Transformation by Oncogenic Ras.
Neoplasms
Synergistic effects of Rapamycin and Fluorouracil to treat a gastric tumor in a PTEN conditional deletion mouse model.
Neoplasms
Synergistic interaction between 17-AAG and phosphatidylinositol 3-kinase inhibition in human malignant glioma cells.
Neoplasms
Synergistic tumor suppression by adenovirus-mediated ING4/PTEN double gene therapy for gastric cancer.
Neoplasms
Synthesis and characterization of folate decorated albumin bio-conjugate nanoparticles loaded with a synthetic curcumin difluorinated analogue.
Neoplasms
Synthetic Essentiality of Metabolic Regulator PDHK1 in PTEN-Deficient Cells and Cancers.
Neoplasms
Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors.
Neoplasms
Synthetic Lethal Targeting of PTEN-Deficient Cancer Cells Using Selective Disruption of Polynucleotide Kinase/Phosphatase.
Neoplasms
T-cell lymphomas in T-cell-specific Pten-deficient mice originate in the thymus.
Neoplasms
Targeted Next-generation Sequencing of Advanced Prostate Cancer Identifies Potential Therapeutic Targets and Disease Heterogeneity.
Neoplasms
Targeted sequencing and intracranial outcomes of patients with lung adenocarcinoma brain metastases treated with radiotherapy.
Neoplasms
Targeting Angiogenesis in Prostate Cancer.
Neoplasms
Targeting mTOR in cancer: renal cell is just a beginning.
Neoplasms
Targeting Nicotinamide N-Methyltransferase and miR-449a in EGFR-TKI-Resistant Non-Small-Cell Lung Cancer Cells.
Neoplasms
Targeting nonclassical oncogenes for therapy in T-ALL.
Neoplasms
Targeting PDK1 in cancer.
Neoplasms
Targeting PTEN in Colorectal Cancers.
Neoplasms
Targeting the dysregulated mammalian target of rapamycin pathway in organ transplantation: killing 2 birds with 1 stone.
Neoplasms
Targeting the mTOR pathway using novel ATP?competitive inhibitors, Torin1, Torin2 and XL388, in the treatment of glioblastoma.
Neoplasms
Temporal Evolution and Management of Fast Flow Vascular Anomalies in PTEN Hamartoma Tumor Syndrome.
Neoplasms
TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta.
Neoplasms
TGF-? signaling alters the pattern of liver tumorigenesis induced by Pten inactivation.
Neoplasms
Tgfbr2 inactivation facilitates cellular plasticity and development of Pten-null prostate cancer.
Neoplasms
The adenovirus-mediated transfer of PTEN inhibits the growth of esophageal cancer cells in vitro and in vivo.
Neoplasms
The Akt/mammalian target of rapamycin pathway is activated and associated with adverse prognosis in soft tissue leiomyosarcomas.
Neoplasms
The anticancer effects of curcumin via targeting the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway.
Neoplasms
The association of Phosphatase and tensin homolog (PTEN) deletion and prostate cancer risk: A meta-analysis.
Neoplasms
The association of phosphatase and tensin homolog deleted on chromosome 10 polymorphisms and lifestyle habits with colorectal cancer risk in a Chinese population.
Neoplasms
The association of PTEN hypermethylation and breast cancer: a meta-analysis.
Neoplasms
The clinical correlation of phosphatase and tensin homolog on chromosome 10, phosphorylation of AKT to an activated state, and odontogenic ameloblast-associated protein in gastrointestinal stromal tumors.
Neoplasms
The Clinical Spectrum of PTEN Hamartoma Tumor Syndrome: Exploring the Value of Thyroid Surveillance.
Neoplasms
The combination of curcumin and 5-fluorouracil in cancer therapy.
Neoplasms
The Complex Landscape of PTEN mRNA Regulation.
Neoplasms
The CtBP1-p300-FOXO3a transcriptional complex represses the expression of the apoptotic regulators Bax and Bim in human osteosarcoma cells.
Neoplasms
The deubiquitylase Ataxin-3 restricts PTEN transcription in lung cancer cells.
Neoplasms
The diverse roles of SPOP in prostate cancer and kidney cancer.
Neoplasms
The effect of reactive oxygen species on the synthesis of prostanoids from arachidonic acid.
Neoplasms
The end of KRAS, and other, cancers? A new way forward.
Neoplasms
The Expression and Prognostic Impact of the PI3K/AKT/mTOR Signaling Pathway in Advanced Esophageal Squamous Cell Carcinoma.
Neoplasms
The expression of microRNA-23a regulates acute myocardial infarction in patients and in vitro through targeting PTEN.
Neoplasms
The expression of microRNAs and exposure to environmental contaminants related to human health: a review.
Neoplasms
The expression of PTEN in the development of mouse cochlear lateral wall.
Neoplasms
The expression of PTEN is associated with improved prognosis in patients with ampullary adenocarcinoma after pancreaticoduodenectomy.
Neoplasms
The functional role of tumor suppressor genes in gliomas: clues for future therapeutic strategies.
Neoplasms
The functions and regulation of the PTEN tumour suppressor.
Neoplasms
The functions of tumor suppressor PTEN in innate and adaptive immunity.
Neoplasms
The Impact of Genetic Variants on PTEN Molecular Functions and Cellular Phenotypes.
Neoplasms
The influence of circular RNAs on autophagy and disease progression.
Neoplasms
The intrinsically disordered tails of PTEN and PTEN-L have distinct roles in regulating substrate specificity and membrane activity.
Neoplasms
The Iron-Regulated Metastasis Suppressor NDRG1 Targets NEDD4L, PTEN, and SMAD4 and Inhibits the PI3K and Ras Signaling Pathways.
Neoplasms
The ISG15-specific protease USP18 regulates stability of PTEN.
Neoplasms
The long non?coding RNA CASC7 inhibits growth and invasion of non?small cell lung cancer cells through phosphatase and tensin homolog upregulation via sequestration of miR?92a.
Neoplasms
The LXR-623-induced long non-coding RNA LINC01125 suppresses the proliferation of breast cancer cells via PTEN/AKT/p53 signaling pathway.
Neoplasms
The molecular genetics of central nervous system tumors.
Neoplasms
The multiple layers of non-genetic regulation of PTEN tumour suppressor activity.
Neoplasms
The murine orthologue of the Golgi-localized TPTE protein provides clues to the evolutionary history of the human TPTE gene family.
Neoplasms
The nuclear transport receptor Importin-11 is a tumor suppressor that maintains PTEN protein.
Neoplasms
The p85beta regulatory subunit of PI3K serves as a substrate for PTEN protein phosphatase activity during insulin mediated signaling.
Neoplasms
The phosphatase and tensin homolog regulates epidermal growth factor receptor (EGFR) inhibitor response by targeting EGFR for degradation.
Neoplasms
The phosphatidylinositol 3-kinase inhibitor, PX-866, is a potent inhibitor of cancer cell motility and growth in three-dimensional cultures.
Neoplasms
The phosphoinositide 3-kinase pathway in human cancer: genetic alterations and therapeutic implications.
Neoplasms
The Phosphoinositide 3-Kinase Signaling Pathway as a Therapeutic Target in Grade IV Brain Tumors.
Neoplasms
The Protective Effect of Cu/Zn-SOD Against Oxidative Stress After PTEN Deletion.
Neoplasms
The protein phosphatase activity of PTEN is essential for regulating neural stem cell differentiation.
Neoplasms
The pseudogene derived from long non-coding RNA DUXAP10 promotes colorectal cancer cell growth through epigenetically silencing of p21 and PTEN.
Neoplasms
The PTEN Conundrum: How to Target PTEN-Deficient Prostate Cancer.
Neoplasms
The PTEN tumor suppressor gene and its role in lymphoma pathogenesis.
Neoplasms
The PTEN Tumor Suppressor Gene in Soft Tissue Sarcoma.
Neoplasms
The PTEN/MMAC1 tumor suppressor induces cell death that is rescued by the AKT/protein kinase B oncogene.
Neoplasms
The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway.
Neoplasms
The PTEN?PI3K Axis in Cancer.
Neoplasms
The relationship between and clinical significance of MicroRNA-32 and phosphatase and tensin homologue expression in colorectal cancer.
Neoplasms
The relevance of PTEN-AKT in relation to NOTCH1-directed treatment strategies in T-cell acute lymphoblastic leukemia.
Neoplasms
The role of PI3K/AKT/FOXO signaling in psoriasis.
Neoplasms
The role of PTEN - HCV core interaction in hepatitis C virus replication.
Neoplasms
The role of PTEN in prostate cancer cell tropism to the bone micro-environment.
Neoplasms
The Role of PTEN in Tumor Angiogenesis.
Neoplasms
The roles of microbial products in the development of colorectal cancer: a review.
Neoplasms
The Skin in Cowden Syndrome.
Neoplasms
The soybean peptide lunasin promotes apoptosis of mammary epithelial cells via induction of tumor suppressor PTEN: similarities and distinct actions from soy isoflavone genistein.
Neoplasms
The tumor suppressor phosphatase and tensin homolog protein (PTEN) is negatively regulated by NF-?b p50 homodimers and involves histone 3 methylation/deacetylation in UROtsa cells chronically exposed to monomethylarsonous acid.
Neoplasms
The tumor suppressor protein PTEN inhibits rat hepatic stellate cell activation.
Neoplasms
The Tumor Suppressor PTEN as Molecular Switch Node Regulating Cell Metabolism and Autophagy: Implications in Immune System and Tumor Microenvironment.
Neoplasms
The tumor suppressor PTEN is exported in exosomes and has phosphatase activity in recipient cells.
Neoplasms
The Tumor Suppressor PTEN Is Necessary for Human Sprouty 2-mediated Inhibition of Cell Proliferation.
Neoplasms
The tumor suppressor PTEN regulates motor responses to striatal dopamine in normal and Parkinsonian animals.
Neoplasms
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate.
Neoplasms
Therapeutic targeting of cancers with loss of PTEN function.
Neoplasms
Thidiazuron suppresses breast cancer progression via targeting miR-132 and miR-202-5p/PTEN axis mediated dysregulation of PI3K/AKT signaling pathway.
Neoplasms
Thyroid involvement in two patients with Bannayan-Riley-Ruvalcaba syndrome.
Neoplasms
Thyroid Nodules and Cancer in Children with PTEN Hamartoma Tumor Syndrome.
Neoplasms
Thyroid pathology in PTEN-hamartoma tumor syndrome: characteristic findings of a distinct entity.
Neoplasms
Tissue distribution and developmental changes of PTEN in the immune organs of chicken and effect of IBDV infection on it.
Neoplasms
Tissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression.
Neoplasms
TMPRSS2-ERG Fusions Are Strongly Linked to Young Patient Age in Low-grade Prostate Cancer.
Neoplasms
Transcriptional activation of p21WAF1 by PTEN/MMAC1 tumor suppressor.
Neoplasms
Transcriptional analysis of the PTEN/MMAC1 pseudogene, psiPTEN.
Neoplasms
Transcriptomic Profiling of Circulating HLA-DR- Myeloid Cells, Compared with HLA-DR+ Myeloid Antigen-presenting Cells.
Neoplasms
Translational Nanomedicine Boosts Anti-PD1 Therapy to Eradicate Orthotopic PTEN-Negative Glioblastoma.
Neoplasms
Treatment of triple-negative metastatic breast cancer: toward individualized targeted treatments or chemosensitization?
Neoplasms
Treatment with PTEN-Long protein inhibits hepatitis C virus replication.
Neoplasms
Treg Destabilization and Reprogramming: Implications for Cancer Immunotherapy.
Neoplasms
TRIM37 Mediates Chemoresistance and Maintenance of Stemness in Pancreatic Cancer Cells via Ubiquitination of PTEN and Activation of the AKT-GSK-3?-?-Catenin Signaling Pathway.
Neoplasms
Tumor suppression by PTEN requires the activation of the PKR-eIF2alpha phosphorylation pathway.
Neoplasms
Tumor suppression effects of bilberry extracts and enzymatically modified isoquercitrin in early preneoplastic liver cell lesions induced by piperonyl butoxide promotion in a two-stage rat hepatocarcinogenesis model.
Neoplasms
Tumor Suppressor PTEN in Breast Cancer: Heterozygosity, Mutations and Protein Expression.
Neoplasms
Tumor suppressor PTEN inhibition of cell invasion, migration, and growth: differential involvement of focal adhesion kinase and p130Cas.
Neoplasms
Tumor-suppressor NF?B2 p100 interacts with ERK2 and stabilizes PTEN mRNA via inhibition of miR-494.
Neoplasms
Tumor-suppressor PTEN affects tau phosphorylation, aggregation, and binding to microtubules.
Neoplasms
Type 1 insulin-like growth factor regulates MT1-MMP synthesis and tumor invasion via PI 3-kinase/Akt signaling.
Neoplasms
Understanding the tumor suppressor PTEN in chronic alcoholism and hepatocellular carcinoma.
Neoplasms
Unique roles of estrogen-dependent Pten control in epithelial cell homeostasis of mouse vagina.
Neoplasms
Unsaturated fatty acids inhibit the expression of tumor suppressor phosphatase and tensin homolog (PTEN) via microRNA-21 up-regulation in hepatocytes.
Neoplasms
Up-regulation of PTEN via LPS/AP-1/NF-?B pathway inhibits trophoblast invasion contributing to preeclampsia.
Neoplasms
Upregulation of DJ-1 expression in melanoma regulates PTEN/AKT pathway for cell survival and migration.
Neoplasms
Upregulation of pAKT(Ser473) expression is involved in progression of HPV-positive oropharyngeal squamous cell carcinoma.
Neoplasms
Upregulation of PTEN by peroxynitrite contributes to cytokine-induced apoptosis in pancreatic beta-cells.
Neoplasms
Upregulation of PTEN suppresses invasion in Tca8113 tongue cancer cells through repression of epithelial-mesenchymal transition (EMT).
Neoplasms
Ursodeoxycholic acid inhibits intimal hyperplasia, vascular smooth muscle cell excessive proliferation, migration via blocking miR-21/PTEN/AKT/mTOR signaling pathway.
Neoplasms
Use of a genetically engineered mouse model as a preclinical tool for HER2 breast cancer.
Neoplasms
Using quantitative proteomic analysis to understand genotype specific intrinsic drug resistance in melanoma.
Neoplasms
V-ATPase-associated prorenin receptor is upregulated in prostate cancer after PTEN loss.
Neoplasms
Valproic acid resensitizes cisplatin-resistant ovarian cancer cells.
Neoplasms
Variable expressivity and novel PTEN mutations in Cowden syndrome.
Neoplasms
Why is PTEN an important tumor suppressor?
Neoplasms
Wild-type phosphatase and tensin homolog deleted on chromosome 10 improved the sensitivity of cells to rapamycin through regulating phosphorylation of Akt in esophageal squamous cell carcinoma.
Neoplasms
WNT/?-catenin signaling regulates mitochondrial activity to alter the oncogenic potential of melanoma in a PTEN-dependent manner.
Neoplasms
WWP1 Gain-of-Function Inactivation of PTEN in Cancer Predisposition.
Neoplasms
WWP2 is a physiological ubiquitin ligase for phosphatase and tensin homolog (PTEN) in mice.
Neoplasms
WWP2 is overexpressed in human oral cancer, determining tumor size and poor prognosis in patients: downregulation of WWP2 inhibits the AKT signaling and tumor growth in mice.
Neoplasms
[Expression of epidermal growth factor receptor and PTEN in malignancy brain tumors]
Neoplasms
[Expression of PTEN and its correlation with angiogenesis in gastric carcinoma]
Neoplasms
[Hereditary colorectal cancer : An update on genetics and entities in terms of differential diagnosis].
Neoplasms
[Mutation and expression of tumor suppressor gene phosphatase and tensin homolog deleted in chromosome 10 in oral squamous cell carcinoma.]
Neoplasms
[Phosphatase and tensin homolog deleted on chromosome ten deficiency sensitizes tumor cells to lithium chloride treatment].
Neoplasms
[PTEN/MMAC1 is apparently not a relevant tumor suppressor gene in development of hereditary breast carcinoma]
Neoplasms
[Research progress of suppressor gene PTEN].
Neoplasms, Germ Cell and Embryonal
Differential Akt signalling in non-seminomatous testicular germ cell tumors.
Neoplasms, Germ Cell and Embryonal
miRNA-1297 induces cell proliferation by targeting phosphatase and tensin homolog in testicular germ cell tumor cells.
Neoplasms, Squamous Cell
Infrequent genetic alterations of the tumor suppressor gene PTEN/MMAC1 in squamous cell carcinoma of the oral cavity.
Nephritis
Expression of PTEN-long nephritis and its effect on renal inflammation.
Nerve Sheath Neoplasms
Conditional Inactivation of Pten with EGFR Overexpression in Schwann Cells Models Sporadic MPNST.
Nerve Sheath Neoplasms
PTEN and NF1 inactivation in Schwann cells produces a severe phenotype in the peripheral nervous system that promotes the development and malignant progression of peripheral nerve sheath tumors.
Nervous System Diseases
Nuclear PTEN deficiency causes microcephaly with decreased neuronal soma size and increased seizure susceptibility.
Nervous System Malformations
Lhermitte-Duclos disease with neurofibrillary tangles in heterotopic cerebral grey matter.
Neuralgia
Involvement of phosphatase and tensin homolog deleted from chromosome 10 in rodent model of neuropathic pain.
Neurilemmoma
Clinicopathologic and Molecular Analysis of a Choroidal Pigmented Schwannoma in the Context of a PTEN Hamartoma Tumor Syndrome.
Neurilemmoma
Insulin-like growth factor-binding protein-1 (IGFBP-1) regulates human schwannoma proliferation, adhesion and survival.
Neuroblastoma
Activation of the phosphatidylinositol 3'-kinase/AKT pathway in neuroblastoma and its regulation by thioredoxin 1.
Neuroblastoma
Analysis of PTEN/MMAC1 alteration in neuroblastoma.
Neuroblastoma
Detecting the spectrum of multigene mutations in non-small cell lung cancer by Snapshot assay.
Neuroblastoma
Examination of mutations in BRAF, NRAS, and PTEN in primary cutaneous melanoma.
Neuroblastoma
GDNF family receptor alpha 2 promotes neuroblastoma cell proliferation by interacting with PTEN.
Neuroblastoma
Heterogeneity in the colorectal primary tumor and the synchronous resected liver metastases prior to and after treatment with an anti-EGFR monoclonal antibody.
Neuroblastoma
Hotspot Mutations Detectable by Next-generation Sequencing in Exhaled Breath Condensates from Patients with Lung Cancer.
Neuroblastoma
Integrin-linked kinase regulates phosphatase and tensin homologue activity to promote tumorigenesis in neuroblastoma cells.
Neuroblastoma
LncRNA cancer susceptibility candidate (CASC7) upregulates phosphatase and tensin homolog by downregulating miR-10a to inhibit neuroblastoma cell proliferation.
Neuroblastoma
Longitudinal Cell-Free DNA Analysis in Patients with Small Cell Lung Cancer Reveals Dynamic Insights into Treatment Efficacy and Disease Relapse.
Neuroblastoma
OncomiRs: the discovery and progress of microRNAs in cancers.
Neuroblastoma
Pleckstrin homology domain-interacting protein (PHIP) as a marker and mediator of melanoma metastasis.
Neuroblastoma
PTEN/MMAC1 overexpression decreases insulin-like growth factor-I-mediated protection from apoptosis in neuroblastoma cells.
Neuroblastoma
Suppression of miR-19b enhanced the cytotoxic effects of mTOR inhibitors in human neuroblastoma cells.
Neurodegenerative Diseases
A pilot study on the effect of lactoferrin on Alzheimer's disease pathological sequelae: Impact of the p-Akt/PTEN pathway.
Neurodegenerative Diseases
PTEN activation contributes to neuronal and synaptic engulfment by microglia in tauopathy.
Neuroectodermal Tumors, Primitive
The regulatory role of aberrant Phosphatase and Tensin Homologue and Liver Kinase B1 on AKT/mTOR/c-Myc axis in pancreatic neuroendocrine tumors.
Neuroendocrine Tumors
Expression of PTEN and mTOR in pancreatic neuroendocrine tumors.
Neuroendocrine Tumors
Loss of PTEN and Increased pAKT Expression Distinguishes Aggressive Low-grade Neuroendocrine Tumors.
Neuroendocrine Tumors
The regulatory role of aberrant Phosphatase and Tensin Homologue and Liver Kinase B1 on AKT/mTOR/c-Myc axis in pancreatic neuroendocrine tumors.
Neurofibromatoses
Conditional Inactivation of Nf1 and Pten in Schwann Cells Results in Abnormal Neuromuscular Junction Maturation.
Neurofibromatoses
Diffuse intestinal ganglioneuromatosis an uncommon manifestation of Cowden syndrome.
Neurofibromatoses
Finding a better drug for epilepsy: the mTOR pathway as an antiepileptogenic target.
Neurofibromatoses
Pathogenic and likely pathogenic variants in PALB2, CHEK2, and other known breast cancer susceptibility genes among 1054 BRCA-negative Hispanics with breast cancer.
Neurofibromatosis 1
Conditional Inactivation of Nf1 and Pten in Schwann Cells Results in Abnormal Neuromuscular Junction Maturation.
Neurofibromatosis 1
Diffuse intestinal ganglioneuromatosis an uncommon manifestation of Cowden syndrome.
Neurofibromatosis 1
Dysregulation of Mammalian Target of Rapamycin Signaling in Mouse Models of Autism.
Neurofibromatosis 1
Finding a better drug for epilepsy: the mTOR pathway as an antiepileptogenic target.
Neurofibromatosis 1
mTOR, a Potential Target to Treat Autism Spectrum Disorder.
Neurofibromatosis 1
Pathogenic and likely pathogenic variants in PALB2, CHEK2, and other known breast cancer susceptibility genes among 1054 BRCA-negative Hispanics with breast cancer.
Neurofibromatosis 1
PTEN and NF1 inactivation in Schwann cells produces a severe phenotype in the peripheral nervous system that promotes the development and malignant progression of peripheral nerve sheath tumors.
Neuroinflammatory Diseases
Modulation of Type-I Interferon Response by hsa-miR-374b-5p During Japanese Encephalitis Virus Infection in Human Microglial Cells.
Neuroinflammatory Diseases
Phosphatase and Tensin Homolog Deleted on Chromosome Ten Knockdown Attenuates Cognitive Deficits by Inhibiting Neuroinflammation in a Mouse Model of Perioperative Neurocognitive Disorder.
Neuroma, Acoustic
MicroRNA-21 Overexpression Contributes to Vestibular Schwannoma Cell Proliferation and Survival.
Nevus
Clinical and sonographic features of pediatric soft-tissue vascular anomalies part 2: vascular malformations.
Nevus
Congenital Limb Overgrowth Syndromes Associated with Vascular Anomalies.
Nevus
Expression of activated Akt and PTEN in malignant melanomas: relationship with clinical outcome.
Nevus
Expression of HSP 90, PTEN and Bcl-2 in conjunctival melanoma.
Nevus
Expression of Phosphatase and Tensin Homologue, phospho-Akt, and p53 in Acral Benign and Malignant Melanocytic Neoplasms (Benign Nevi, Dysplastic Nevi, and Acral Melanomas).
Nevus, Pigmented
PTEN/MMAC1 expression in melanoma resection specimens.
Nijmegen Breakage Syndrome
Association of Single-Nucleotide Polymorphisms in Monoubiquitinated FANCD2-DNA Damage Repair Pathway Genes With Breast Cancer in the Chinese Population.
Non-alcoholic Fatty Liver Disease
Oral intake of genetically engineered high-carotenoid corn ameliorates hepatomegaly and hepatic steatosis in PTEN haploinsufficient mice.
Non-alcoholic Fatty Liver Disease
Pathogenesis and significance of hepatitis C virus steatosis: an update on survival strategy of a successful pathogen.
Non-alcoholic Fatty Liver Disease
The ménage à trois of autophagy, lipid droplets and liver disease.
Obesity
Exercise Counterbalances Rho/ROCK2 Signaling Impairment in the Skeletal Muscle and Ameliorates Insulin Sensitivity in Obese Mice.
Obesity
The PI3K pathway preserves metabolic health through MARCO-dependent lipid uptake by adipose tissue macrophages.
Oligodendroglioma
Mechanisms of action of rapamycin in gliomas.
Oligodendroglioma
Molecular genetic analysis of non-astrocytic gliomas.
Oligodendroglioma
Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11.
Optic Atrophy, Autosomal Dominant
Curcumin prevents cisplatin-induced renal alterations in mitochondrial bioenergetics and dynamic.
Optic Nerve Injuries
Lipidomics dataset of PTEN deletion-induced optic nerve regeneration mouse model.
Optic Nerve Injuries
Nipradilol Promotes Axon Regeneration Through S-Nitrosylation of PTEN in Retinal Ganglion Cells.
Optic Nerve Injuries
Viral vector-based improvement of optic nerve regeneration: characterization of individual axons' growth patterns and synaptogenesis in a visual target.
Oral Manifestations
Oral manifestations of phosphatase and tensin homolog hamartoma tumor syndrome: a report of three cases.
Oral Submucous Fibrosis
PTEN and ?-SMA Expression and Diagnostic Role in Oral Submucous Fibrosis and Oral Squamous Cell Carcinoma with Concomitant Oral Submucous Fibrosis.
Osteosarcoma
Association between PTEN and clinical-pathological features of osteosarcoma.
Osteosarcoma
Copy number gains in EGFR and copy number losses in PTEN are common events in osteosarcoma tumors.
Osteosarcoma
Efficient miRNA Inhibitor with GO-PEI Nanosheets for Osteosarcoma Suppression by Targeting PTEN.
Osteosarcoma
Expression of NF-?B and PTEN in osteosarcoma and its clinical significance.
Osteosarcoma
Long non-coding RNA phosphatase and tensin homolog pseudogene 1 suppresses osteosarcoma cell growth via the phosphoinositide 3-kinase/protein kinase B signaling pathway.
Osteosarcoma
MicroRNA-214 regulates osteosarcoma survival and growth by directly targeting phosphatase and tensin homolog.
Osteosarcoma
miR-155 Affects Osteosarcoma MG-63 Cell Autophagy Induced by Adriamycin Through Regulating PTEN-PI3K/AKT/mTOR Signaling Pathway.
Osteosarcoma
MiR-19a regulates the cell growth and apoptosis of osteosarcoma stem cells by targeting PTEN.
Osteosarcoma
Novel Germline
Osteosarcoma
SLC25A22 Promotes Proliferation and Metastasis of Osteosarcoma Cells via the PTEN Signaling Pathway.
Osteosarcoma
Small molecule TSC01682 inhibits osteosarcoma cell growth by specifically disrupting the CUL4B-DDB1 interaction and decreasing the ubiquitination of CRL4B E3 ligase substrates.
Osteosarcoma
The CtBP1-p300-FOXO3a transcriptional complex represses the expression of the apoptotic regulators Bax and Bim in human osteosarcoma cells.
Osteosarcoma
[Effect of Parkinson's disease-relevant protein DJ-1 on cell proliferation, apoptosis, invasion and migration in human osteosarcoma cells].
Ovarian Neoplasms
ABT-737 and pictilisib synergistically enhance pitavastatin-induced apoptosis in ovarian cancer cells.
Ovarian Neoplasms
E-cadherin inhibits tumor cell growth by suppressing PI3K/Akt signaling via ?-catenin-Egr1-mediated PTEN expression.
Ovarian Neoplasms
Expression levels of PTEN, HIF-1?, and VEGF as prognostic factors in ovarian cancer.
Ovarian Neoplasms
Frequent PTEN/MMAC mutations in endometrioid but not serous or mucinous epithelial ovarian tumors.
Ovarian Neoplasms
METTL3-mediated maturation of miR-126-5p promotes ovarian cancer progression via PTEN-mediated PI3K/Akt/mTOR pathway.
Ovarian Neoplasms
MicroRNA-106a regulates phosphatase and tensin homologue expression and promotes the proliferation and invasion of ovarian cancer cells.
Ovarian Neoplasms
miR-205 regulates the proliferation and invasion of ovarian cancer cells via suppressing PTEN/SMAD4 expression.
Ovarian Neoplasms
miR-214 targets the PTEN-mediated PI3K/Akt signaling pathway and regulates cell proliferation and apoptosis in ovarian cancer.
Ovarian Neoplasms
Mutation analysis of the putative tumor suppressor PTEN/MMAC1 in human ovarian cancer.
Ovarian Neoplasms
Overcoming cisplatin resistance by targeting the MTDH-PTEN interaction in ovarian cancer with sera derived from rats exposed to Guizhi Fuling wan extract.
Ovarian Neoplasms
Pathogenic and likely pathogenic variants in PALB2, CHEK2, and other known breast cancer susceptibility genes among 1054 BRCA-negative Hispanics with breast cancer.
Ovarian Neoplasms
Phosphatase and Tensin Homolog Is a Potential Target for Ovarian Cancer Sensitization to Cytotoxic Agents.
Ovarian Neoplasms
Recombinant adenovirus-mediated overexpression of PTEN and KRT10 improves cisplatin resistance of ovarian cancer in vitro and in vivo.
Ovarian Neoplasms
Structural mutation analysis of PTEN and its genotype-phenotype correlations in endometriosis and cancer.
Ovarian Neoplasms
Upregulation of microRNA-18b induces phosphatase and tensin homolog to accelerate the migration and invasion abilities of ovarian cancer.
Pancreatic Intraductal Neoplasms
Somatic mutations in PIK3CA and activation of AKT in intraductal tubulopapillary neoplasms of the pancreas.
Pancreatic Neoplasms
A blockade of PD-L1 produced antitumor and antimetastatic effects in an orthotopic mouse pancreatic cancer model via the PI3K/Akt/mTOR signaling pathway.
Pancreatic Neoplasms
Akt activation by arachidonic acid metabolism occurs via oxidation and inactivation of PTEN tumor suppressor.
Pancreatic Neoplasms
Analysis of PTEN/MMAC1 alterations in aerodigestive tract tumors.
Pancreatic Neoplasms
miR-486 Promotes Capan-2 Pancreatic Cancer Cell Proliferation by Targeting Phosphatase and Tensin Homolog Deleted on Chromosome 10 (PTEN).
Pancreatic Neoplasms
Peroxisome proliferator-activated receptor-? inhibits pancreatic cancer cell invasion and metastasis via regulating MMP-2 expression through PTEN.
Pancreatic Neoplasms
RAS/ERK modulates TGFbeta-regulated PTEN expression in human pancreatic adenocarcinoma cells.
Pancreatic Neoplasms
The role of oxysterol binding protein-related protein 5 in pancreatic cancer.
Pancreatic Neoplasms
[Exogenous PTEN enhances apoptosis in pancreas cancer cell line ASPC-1 induced by hypoxia]
Papilloma
Dysregulated Expression of Phosphorylated Epidermal Growth Factor Receptor and Phosphatase and Tensin Homologue in Canine Cutaneous Papillomas and Squamous Cell Carcinomas.
Papilloma
Molecular carcinogenesis in equine penile cancer: A potential animal model for human penile cancer.
Papilloma
Overexpression of PTEN/MMAC1 and decreased activation of Akt in human papillomavirus-infected laryngeal papillomas.
Papilloma
PTEN is a negative regulator of STAT3 activation in human papillomavirus-infected cells.
Parasitic Diseases
Overexpression of phosphatase and tensin homolog improves fitness and decreases Plasmodium falciparum development in Anopheles stephensi.
Parkinson Disease
Analysis of the regulatory and catalytic domains of PTEN-induced kinase-1 (PINK1).
Parkinson Disease
Clinically reported heterozygous mutations in the PINK1 kinase domain exert a gene dosage effect.
Parkinson Disease
Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: analysis of substrate specificity and impact of mutations.
Parkinson Disease
e-Cadherin in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Parkinson Disease.
Parkinson Disease
Elevated nuclear phosphatase and tensin homolog (PTEN) and altered insulin signaling in substantia nigral region of patients with Parkinson's disease.
Parkinson Disease
Loss of Non-Apoptotic Role of Caspase-3 in the PINK1 Mouse Model of Parkinson's Disease.
Parkinson Disease
Microtubule Affinity-regulating Kinase 2 (MARK2) Turns on Phosphatase and Tensin Homolog (PTEN)-induced Kinase 1 (PINK1) at Thr-313, a Mutation Site in Parkinson Disease: EFFECTS ON MITOCHONDRIAL TRANSPORT.
Parkinson Disease
Mitochondrial Protein PINK1 Positively Regulates RLR Signaling.
Parkinson Disease
Parkin stabilizes PINK1 through direct interaction.
Parkinson Disease
PINK1 signaling in mitochondrial homeostasis and in aging (Review).
Parkinson Disease
PINK1 suppresses alpha-synuclein-induced neuronal injury: a novel mechanism in protein phosphatase 2A activation.
Parkinson Disease
PINK1-dependent recruitment of Parkin to mitochondria in mitophagy.
Parkinson Disease
PINK1/Parkin Mediated Mitophagy, Ca2+ Signalling, and ER-Mitochondria Contacts in Parkinson's Disease.
Parkinson Disease
The identified clinical features of Parkinson's disease in homo-, heterozygous and digenic variants of PINK1.
Parkinson Disease
[Effect of Parkinson's disease-relevant protein DJ-1 on cell proliferation, apoptosis, invasion and migration in human osteosarcoma cells].
Peutz-Jeghers Syndrome
Clinical and Histologic Overlap and Distinction Among Various Hamartomatous Polyposis Syndromes.
Peutz-Jeghers Syndrome
Hamartomatous polyposis syndromes.
Peutz-Jeghers Syndrome
[Hereditary colorectal cancer : An update on genetics and entities in terms of differential diagnosis].
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase deficiency
3-Phosphoinositide-dependent protein kinase-1 as an emerging target in the management of breast cancer.
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase deficiency
c-Myc phosphorylation by PKC? represses prostate tumorigenesis.
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase deficiency
Phosphatase and tensin homolog deficiency and resistance to trastuzumab and chemotherapy.
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase deficiency
Phosphatase and tensin homologue deficiency in glioblastoma confers resistance to radiation and temozolomide that is reversed by the protease inhibitor nelfinavir.
Pituitary Neoplasms
Correlation of NEDD4-1 and PTEN expression with the invasive capacity of pituitary adenomas.
Pituitary Neoplasms
Expression and clinical significance of EGR-1 and PTEN in the pituitary tumors of elderly patients.
Pituitary Neoplasms
MicroRNA-106b promotes pituitary tumor cell proliferation and invasion through PI3K/AKT signaling pathway by targeting PTEN.
Pituitary Neoplasms
Phosphatase and tensin homologue and pituitary tumor-transforming gene in pituitary adenomas. Clinical-pathologic and immunohistochemical analysis.
Polycystic Ovary Syndrome
Association of genetic variations in phosphatase and tensin homolog (PTEN) gene with polycystic ovary syndrome in South Indian women: a case control study.
Polyhydramnios
Finding a better drug for epilepsy: the mTOR pathway as an antiepileptogenic target.
Pre-Eclampsia
Up-regulation of PTEN via LPS/AP-1/NF-?B pathway inhibits trophoblast invasion contributing to preeclampsia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Control of amino acid transport coordinates metabolic reprogramming in T-cell malignancy.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Enhancer of zeste homolog 2 is overexpressed and contributes to epigenetic inactivation of p21 and phosphatase and tensin homolog in B-cell acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
FAK mediates a compensatory survival signal parallel to PI3K-AKT in PTEN-null T-ALL cells.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Notch1 receptor regulates AKT protein activation loop (Thr308) dephosphorylation through modulation of the PP2A phosphatase in phosphatase and tensin homolog (PTEN)-null T-cell acute lymphoblastic leukemia cells.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
PTEN microdeletions in T-cell acute lymphoblastic leukemia are caused by illegitimate RAG-mediated recombination events.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Repression of BIM mediates survival signaling by MYC and AKT in high-risk T-cell acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Synergistic activity of rapamycin and dexamethasone in vitro and in vivo in acute lymphoblastic leukemia via cell-cycle arrest and apoptosis.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
The relevance of PTEN-AKT in relation to NOTCH1-directed treatment strategies in T-cell acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Expression and Significance of PTEN and Survivin in Acute Lymphoblastic Leukemia].
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Clinical-Grade Peptide-Based Inhibition of CK2 Blocks Viability and Proliferation of T-ALL Cells and Counteracts IL-7 Stimulation and Stromal Support.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor (2S)-1-(1H-Indol-3-yl)-3-[5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxypropan2-amine (A443654) in T-cell acute lymphoblastic leukemia.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Single-cell profiling of pediatric T-cell acute lymphoblastic leukemia: Impact of PTEN exon 7 mutation on PI3K/Akt and JAK-STAT signaling pathways.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Suppression of leukemia development caused by PTEN loss.
Primary Ovarian Insufficiency
Hippo signaling in the ovary and polycystic ovarian syndrome.
Primary Ovarian Insufficiency
Intraovarian control of early folliculogenesis.
Primary Ovarian Insufficiency
Mutational analysis of the PTEN gene in women with premature ovarian failure.
Prostatic Intraepithelial Neoplasia
Additive Effect of Zfhx3/Atbf1 and Pten Deletion on Mouse Prostatic Tumorigenesis.
Prostatic Intraepithelial Neoplasia
Methylseleninic Acid Superactivates p53-Senescence Cancer Progression Barrier in Prostate Lesions of Pten-Knockout Mouse.
Prostatic Intraepithelial Neoplasia
Proteomic and transcriptomic profiling of Pten gene-knockout mouse model of prostate cancer.
Prostatic Neoplasms
10q23.3 loss of heterozygosity is higher in lymph node-positive (pT2-3,N+) versus lymph node-negative (pT2-3,N0) prostate cancer.
Prostatic Neoplasms
2',4'-dihydroxychalcone, a flavonoid isolated from Herba oxytropis, suppresses PC-3 human prostate cancer cell growth by induction of apoptosis.
Prostatic Neoplasms
A multicenter study shows PTEN deletion is strongly associated with seminal vesicle involvement and extracapsular extension in localized prostate cancer.
Prostatic Neoplasms
A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis.
Prostatic Neoplasms
A phase I dose-escalation study of enzalutamide in combination with the AKT inhibitor AZD5363 (capivasertib) in patients with metastatic castration-resistant prostate cancer.
Prostatic Neoplasms
A Phase II Trial of Temsirolimus in Men With Castration-Resistant Metastatic Prostate Cancer.
Prostatic Neoplasms
Activation of Mammalian Target of Rapamycin Signaling Pathway Markers in Minute Adenocarcinoma of the Prostate.
Prostatic Neoplasms
Additive Effect of Zfhx3/Atbf1 and Pten Deletion on Mouse Prostatic Tumorigenesis.
Prostatic Neoplasms
Adiponectin signals in prostate cancer cells through Akt to activate the mammalian target of rapamycin pathway.
Prostatic Neoplasms
AKT and cytosolic phospholipase A2? form a positive loop in prostate cancer cells.
Prostatic Neoplasms
AKT-mediated stabilization of histone methyltransferase WHSC1 promotes prostate cancer metastasis.
Prostatic Neoplasms
Aloe-emodin suppresses prostate cancer by targeting the mTOR complex 2.
Prostatic Neoplasms
Alternative pathways to prostate carcinoma activate prostate stem cell antigen expression.
Prostatic Neoplasms
Blocked autophagy using lysosomotropic agents sensitizes resistant prostate tumor cells to the novel Akt inhibitor AZD5363.
Prostatic Neoplasms
Cancer genetics-guided discovery of serum biomarker signatures for diagnosis and prognosis of prostate cancer.
Prostatic Neoplasms
Cdc6 and cyclin E2 are PTEN-regulated genes associated with human prostate cancer metastasis.
Prostatic Neoplasms
Chromatin remodeling ATPase BRG1 and PTEN are synthetic lethal in prostate cancer.
Prostatic Neoplasms
Clinical Utility and Biologic Implications of Phosphatase and Tensin Homolog (PTEN) and ETS-related Gene (ERG) in Prostate Cancer.
Prostatic Neoplasms
Combination of PTEN gene therapy and radiation inhibits the growth of human prostate cancer xenografts.
Prostatic Neoplasms
Concomitant loss of EAF2/U19 and Pten synergistically promotes prostate carcinogenesis in the mouse model.
Prostatic Neoplasms
Conditional PTEN-deficient mice as a prostate cancer chemoprevention model.
Prostatic Neoplasms
COUP-TFII inhibits TGF-?-induced growth barrier to promote prostate tumorigenesis.
Prostatic Neoplasms
CXCR4 and PTEN are involved in the anti-metastatic regulation of anethole in DU145 prostate cancer cells.
Prostatic Neoplasms
Diagnostic value of 68Ga-PSMA PET/CT for detection of PTEN expression in prostate cancer: a pilot study.
Prostatic Neoplasms
Discovery and functional characterization of a neomorphic PTEN mutation.
Prostatic Neoplasms
Effect of Preanalytic Variables on an Automated PTEN Immunohistochemistry Assay for Prostate Cancer.
Prostatic Neoplasms
Enhanced growth inhibition of prostate cancer in vitro and in vivo by a recombinant adenovirus-mediated dual-aptamer modified drug delivery system.
Prostatic Neoplasms
Epigenetic modulation of PTEN expression during antiandrogenic therapies in human prostate cancer.
Prostatic Neoplasms
Eupafolin suppresses prostate cancer by targeting phosphatidylinositol 3-kinase-mediated Akt signaling.
Prostatic Neoplasms
Expression and significance of PTEN and Claudin-3 in prostate cancer.
Prostatic Neoplasms
Four MicroRNAs Promote Prostate Cell Proliferation with Regulation of PTEN and Its Downstream Signals In Vitro.
Prostatic Neoplasms
Frequency of PTEN alterations, TMPRSS2-ERG fusion and their association in prostate cancer.
Prostatic Neoplasms
Frequent inactivation of PTEN/MMAC1 in primary prostate cancer.
Prostatic Neoplasms
Genomic deletion of PTEN is associated with tumor progression and early PSA recurrence in ERG fusion-positive and fusion-negative prostate cancer.
Prostatic Neoplasms
Genomic Rearrangements of PTEN in Prostate Cancer.
Prostatic Neoplasms
Heterogeneity and chronology of PTEN deletion and ERG fusion in prostate cancer.
Prostatic Neoplasms
High Efficacy of Combination Therapy Using PI3K/AKT Inhibitors with Androgen Deprivation in Prostate Cancer Preclinical Models.
Prostatic Neoplasms
High throughput assessment of biomarkers in tissue microarrays using artificial intelligence: PTEN loss as a proof-of-principle in multi-center prostate cancer cohorts.
Prostatic Neoplasms
IL-6/STAT3/ARF: the guardians of senescence, cancer progression and metastasis in prostate cancer.
Prostatic Neoplasms
In prostate cancer needle biopsies, detections of PTEN loss by fluorescence in situ hybridization (FISH) and by immunohistochemistry (IHC) are concordant and show consistent association with upgrading.
Prostatic Neoplasms
In silico approach of naringin as potent phosphatase and tensin homolog (PTEN) protein agonist against prostate cancer.
Prostatic Neoplasms
Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression.
Prostatic Neoplasms
Increased expression of miR-153 predicts poor prognosis for patients with prostate cancer.
Prostatic Neoplasms
Inflammation-associated pathologies in a case of prostate schistosomiasis: Implications for a causal role in prostate carcinogenesis.
Prostatic Neoplasms
Inhibitors of mTOR reverse doxorubicin resistance conferred by PTEN status in prostate cancer cells.
Prostatic Neoplasms
Interfocal heterogeneity of PTEN/MMAC1 gene alterations in multiple metastatic prostate cancer tissues.
Prostatic Neoplasms
Is STAT3 and PTEN Expression Altered in Canine Prostate Cancer?
Prostatic Neoplasms
JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate.
Prostatic Neoplasms
Klf5 deletion promotes Pten deletion-initiated luminal-type mouse prostate tumors through multiple oncogenic signaling pathways.
Prostatic Neoplasms
Knockdown of Phospholipase C? (PLC?) Inhibits Cell Proliferation via Phosphatase and Tensin Homolog Deleted on Chromosome 10 (PTEN)/AKT Signaling Pathway in Human Prostate Cancer.
Prostatic Neoplasms
Long-term androgen-ablation causes increased resistance to PI3K/Akt pathway inhibition in prostate cancer cells.
Prostatic Neoplasms
Loss of neutral endopeptidase and activation of protein kinase B (Akt) is associated with prostate cancer progression.
Prostatic Neoplasms
Methylseleninic Acid Superactivates p53-Senescence Cancer Progression Barrier in Prostate Lesions of Pten-Knockout Mouse.
Prostatic Neoplasms
miR-20b promotes cellular proliferation and migration by directly regulating phosphatase and tensin homolog in prostate cancer.
Prostatic Neoplasms
Mutations of PTEN/MMAC1 in primary prostate cancers from Chinese patients.
Prostatic Neoplasms
Organ-specific regulation of CHD1 by acute PTEN and p53 loss in mice.
Prostatic Neoplasms
Pathological effects of prostate cancer correlate with neuroendocrine differentiation and PTEN expression after bicalutamide monotherapy.
Prostatic Neoplasms
Paucity of PD-L1 expression in prostate cancer: innate and adaptive immune resistance.
Prostatic Neoplasms
Pharmacological targeting of the integrated protein kinase B, phosphatase and tensin homolog deleted on chromosome 10, and transforming growth factor-beta pathways in prostate cancer.
Prostatic Neoplasms
Phase 2 trial of single-agent everolimus in chemotherapy-naive patients with castration-resistant prostate cancer (SAKK 08/08).
Prostatic Neoplasms
Phase Ib dose-finding study of abiraterone acetate plus buparlisib (BKM120) or dactolisib (BEZ235) in patients with castration-resistant prostate cancer.
Prostatic Neoplasms
Predicting high risk disease using serum and DNA biomarkers.
Prostatic Neoplasms
Prognostic value of ERG, PTEN, CRISP3 and SPINK1 in predicting biochemical recurrence in prostate cancer.
Prostatic Neoplasms
Prognostic value of PTEN in de novo diagnosed metastatic prostate cancer.
Prostatic Neoplasms
Prognostic value of PTEN loss in men with conservatively managed localised prostate cancer.
Prostatic Neoplasms
Prostate-specific G-protein-coupled receptor collaborates with loss of PTEN to promote prostate cancer progression.
Prostatic Neoplasms
Prostatic inflammation enhances basal-to-luminal differentiation and accelerates initiation of prostate cancer with a basal cell origin.
Prostatic Neoplasms
Proteomic and transcriptomic profiling of Pten gene-knockout mouse model of prostate cancer.
Prostatic Neoplasms
PTEN and ERG detection in multiparametric magnetic resonance imaging/ultrasound fusion targeted prostate biopsy compared to systematic biopsy.
Prostatic Neoplasms
PTEN deletion drives aberrations of DNA methylome and transcriptome in different stages of prostate cancer.
Prostatic Neoplasms
PTEN Expression in Prostate Cancer: Relationship With Clinicopathologic Features and Multiparametric MRI Findings.
Prostatic Neoplasms
PTEN Loss in a Prostate Cancer Cohort From Jordan.
Prostatic Neoplasms
PTEN losses exhibit heterogeneity in multifocal prostatic adenocarcinoma and are associated with higher Gleason grade.
Prostatic Neoplasms
PTEN Protein Loss and Clinical Outcome from Castration-resistant Prostate Cancer Treated with Abiraterone Acetate.
Prostatic Neoplasms
PTEN/MMAC1 is infrequently mutated in pT2 and pT3 carcinomas of the prostate.
Prostatic Neoplasms
PTEN/MMAC1 mutations in prostate cancer.
Prostatic Neoplasms
Recurrent prostate cancer genomic alterations predict response to brachytherapy treatment.
Prostatic Neoplasms
Restoration of tumour-growth suppression in vivo via systemic nanoparticle-mediated delivery of PTEN mRNA.
Prostatic Neoplasms
Resveratrol and pterostilbene as a microRNA-mediated chemopreventive and therapeutic strategy in prostate cancer.
Prostatic Neoplasms
ROS enhances CXCR4-mediated functions through inactivation of PTEN in prostate cancer cells.
Prostatic Neoplasms
Silencing miRNA-1297 suppresses the invasion and migration of prostate cancer cells via targeting modulation of PTEN and blocking of the AKT/ERK pathway.
Prostatic Neoplasms
Somatic mutation of PTEN in bladder carcinoma.
Prostatic Neoplasms
Sprouty2, PTEN, and PP2A interact to regulate prostate cancer progression.
Prostatic Neoplasms
The 17-Gene Genomic Prostate Score Assay Predicts Outcome After Radical Prostatectomy Independent of PTEN Status.
Prostatic Neoplasms
The association of Phosphatase and tensin homolog (PTEN) deletion and prostate cancer risk: A meta-analysis.
Prostatic Neoplasms
The diverse roles of SPOP in prostate cancer and kidney cancer.
Prostatic Neoplasms
The influence of growth hormone/insulin-like growth factor deficiency on prostatic dysplasia in pbARR2-Cre, PTEN knockout mice.
Prostatic Neoplasms
The p85beta regulatory subunit of PI3K serves as a substrate for PTEN protein phosphatase activity during insulin mediated signaling.
Prostatic Neoplasms
The protein kinase C super-family member PKN is regulated by mTOR and influences differentiation during prostate cancer progression.
Prostatic Neoplasms
The PTEN Conundrum: How to Target PTEN-Deficient Prostate Cancer.
Prostatic Neoplasms
The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway.
Prostatic Neoplasms
The role of PTEN in prostate cancer cell tropism to the bone micro-environment.
Prostatic Neoplasms
Uncoupling of the epidermal growth factor receptor from downstream signal transduction molecules guides the acquired resistance to gefitinib in prostate cancer cells.
Prostatic Neoplasms
V-ATPase-associated prorenin receptor is upregulated in prostate cancer after PTEN loss.
Proteus Syndrome
Clinical and sonographic features of pediatric soft-tissue vascular anomalies part 2: vascular malformations.
Proteus Syndrome
Congenital Limb Overgrowth Syndromes Associated with Vascular Anomalies.
Proteus Syndrome
Phosphatase and Tensin Homolog Hamartoma Tumor Syndrome: A Case Report.
Psoriasis
Nuclear factor-?B pathway activation and phosphatase and tensin homolog downregulation in psoriasis.
Psoriasis
The role of PI3K/AKT/FOXO signaling in psoriasis.
Pulmonary Arterial Hypertension
Prostaglandin E1 Attenuates Pulmonary Artery Remodeling by Activating Phosphorylation of CREB and the PTEN Signaling Pathway.
Pulmonary Disease, Chronic Obstructive
Cigarette smoke extract amplifies NADPH oxidase-dependent ROS production to inactivate PTEN by oxidation in BEAS-2B cells.
Pulmonary Disease, Chronic Obstructive
Decreased phosphatase PTEN amplifies PI3K signaling and enhances proinflammatory cytokine release in COPD.
Pulmonary Disease, Chronic Obstructive
PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis.
Rectal Neoplasms
KRAS Mutation Status and Clinical Outcome of Preoperative Chemoradiation With Cetuximab in Locally Advanced Rectal Cancer: A Pooled Analysis of 2 Phase II Trials.
Rectal Neoplasms
[Expression of phosphatase and tensin homolog in lower rectal cancer on neoadjuvant chemoradiotherapy].
Reperfusion Injury
MicroRNA-687 Induced by Hypoxia-Inducible Factor-1 Targets Phosphatase and Tensin Homolog in Renal Ischemia-Reperfusion Injury.
Reperfusion Injury
PTEN inhibitors cause a negative inotropic and chronotropic effect in mice.
Reperfusion Injury
[Protective role of PTEN inhibition against liver ischemia-reperfusion injury in mice and its underlying mechanisms].
Retinal Diseases
PTEN Expression Regulates Gap Junction Connectivity in the Retina.
Retinoblastoma
Arterialization of a vein graft promotes cell cycle progression through Akt and p38 mitogen-activated protein kinase pathways: impact of the preparation procedure.
Retinoblastoma
Bevacizumab plus 5-fluorouracil induce growth suppression in the CWR-22 and CWR-22R prostate cancer xenografts.
Retinoblastoma
Beyond Trophic Factors: Exploiting the Intrinsic Regenerative Properties of Adult Neurons.
Retinoblastoma
Evasion of anti-growth signaling: a key step in tumorigenesis and potential target for treatment and prophylaxis by natural compounds.
Retinoblastoma
Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines.
Retinoblastoma
Longitudinal Cell-Free DNA Analysis in Patients with Small Cell Lung Cancer Reveals Dynamic Insights into Treatment Efficacy and Disease Relapse.
Retinoblastoma
MED12 exon 2 mutation is uncommon in intravenous leiomyomatosis: clinicopathologic features and molecular study.
Retinoblastoma
Mice lacking dystrophin or alpha sarcoglycan spontaneously develop embryonal rhabdomyosarcoma with cancer-associated p53 mutations and alternatively spliced or mutant Mdm2 transcripts.
Retinoblastoma
Mitogenic signaling and the relationship to cell cycle regulation in astrocytomas.
Retinoblastoma
Proteome profile changes that are differentially regulated by lipid and protein phosphatase activities of tumor suppressor PTEN in PTEN-expressing U-87 MG human glioblastoma cells.
Retinoblastoma
Regulating tumor suppressor genes: post-translational modifications.
Retinoblastoma
Regulation of cancer metabolism by oncogenes and tumor suppressors.
Retinoblastoma
Targeted Next-generation Sequencing of Advanced Prostate Cancer Identifies Potential Therapeutic Targets and Disease Heterogeneity.
Rett Syndrome
Dysregulation of Mammalian Target of Rapamycin Signaling in Mouse Models of Autism.
Sarcoma
A versatile modular vector system for rapid combinatorial mammalian genetics.
Sarcoma
Cancer gene panel analysis of cultured circulating tumor cells and primary tumor tissue from patients with breast cancer.
Sarcoma
Concordance of Predictive Markers for EGFR Inhibitors in Primary Tumors and Metastases in Colorectal Cancer: A Review.
Sarcoma
Conjunctival Melanoma: Genetic and Epigenetic Insights of a Distinct Type of Melanoma.
Sarcoma
Detecting the spectrum of multigene mutations in non-small cell lung cancer by Snapshot assay.
Sarcoma
EGFR, KRAS, BRAF, PTEN, and PIK3CA mutation in plasma of small cell lung cancer patients.
Sarcoma
Evolutionary etiology of high-grade astrocytomas.
Sarcoma
Expression Patterns of Growth and Survival Genes with Prognostic Implications in Advanced Pancreatic Cancer.
Sarcoma
Genetic alterations in the RAS/RAF/mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt signaling pathways in the follicular variant of papillary thyroid carcinoma.
Sarcoma
Hotspot Mutations Detectable by Next-generation Sequencing in Exhaled Breath Condensates from Patients with Lung Cancer.
Sarcoma
Identification of key microRNAs, transcription factors and genes associated with congenital obstructive nephropathy in a mouse model of megabladder.
Sarcoma
Molecular association of functioning stroma with carcinoma cells in the ovary: A preliminary study.
Sarcoma
Next-generation sequencing-based identification of EGFR and NOTCH2 complementary mutations in non-small cell lung cancer.
Sarcoma
Prevalence and prognostic influence of genomic changes of EGFR pathway markers in synovial sarcoma.
Sarcoma
PTEN/MMAC1 gene mutation is a rare event in soft tissue sarcomas without specific balanced translocations.
Sarcoma
The PTEN Tumor Suppressor Gene in Soft Tissue Sarcoma.
Sarcoma
Utilization of Unlabeled Probes for the Detection of Fibroblast Growth Factor Receptor 2 Exons 7 and 12 Mutations in Endometrial Carcinoma.
Scleroderma, Diffuse
Fibrosis caused by loss of PTEN expression by fibroblasts is crucially dependent on CCN2.
Scleroderma, Systemic
Fibrosis caused by loss of PTEN expression by fibroblasts is crucially dependent on CCN2.
Scleroderma, Systemic
Role of the mTOR pathway in minor salivary gland changes in Sjogren's syndrome and systemic sclerosis.
Seizures
Therapeutic inhibition of mTORC2 rescues the behavioral and neurophysiological abnormalities associated with Pten-deficiency.
Seminoma
Estrogen receptor beta (ER?) produces autophagy and necroptosis in human seminoma cell line through the binding of the Sp1 on the phosphatase and tensin homolog deleted from chromosome 10 (PTEN) promoter gene.
Seminoma
Seminoma component of mixed testicular germ cell tumor shows a higher incidence of loss of heterozygosity than pure-type seminoma.
Sjogren's Syndrome
Role of the mTOR pathway in minor salivary gland changes in Sjogren's syndrome and systemic sclerosis.
Skin Neoplasms
Role of vitamin D3 in modulation of ?Np63? expression during UVB induced tumor formation in SKH-1 mice.
Small Cell Lung Carcinoma
Alterations of PTEN/MMAC1, a candidate tumor suppressor gene, and its homologue, PTH2, in small cell lung cancer cell lines.
Small Cell Lung Carcinoma
Concurrent epidermal growth factor receptor T790M secondary mutation and epithelial-mesenchymal transition in a lung adenocarcinoma patient with EGFR-TKI drug resistance.
Small Cell Lung Carcinoma
PTEN/MMAC1 mutations identified in small cell, but not in non-small cell lung cancers.
Spinal Cord Injuries
AAVshRNA-mediated suppression of PTEN in adult rats in combination with salmon fibrin administration enables regenerative growth of corticospinal axons and enhances recovery of voluntary motor function after cervical spinal cord injury.
Spinal Cord Injuries
Conditional genetic deletion of PTEN after a spinal cord injury enhances regenerative growth of CST axons and motor function recovery in mice.
Spinal Cord Injuries
Intranasal Delivery of Mesenchymal Stem Cell Derived Exosomes Loaded with Phosphatase and Tensin Homolog siRNA Repairs Complete Spinal Cord Injury.
Spinal Cord Injuries
ISP and PAP4 peptides promote motor functional recovery after peripheral nerve injury.
Spinal Cord Injuries
Long-term consequences of conditional genetic deletion of PTEN in the sensorimotor cortex of neonatal mice.
Spinal Cord Injuries
MicroRNA-92a-3p enhances functional recovery and suppresses apoptosis after spinal cord injury via targeting phosphatase and tensin homolog.
Spinal Cord Injuries
PTEN expression in astrocytic processes after spinal cord injury.
Spinal Cord Injuries
Systemic bisperoxovanadium activates Akt/mTOR, reduces autophagy, and enhances recovery following cervical spinal cord injury.
Squamous Cell Carcinoma of Head and Neck
Analysis of PTEN/MMAC1 alterations in aerodigestive tract tumors.
Squamous Cell Carcinoma of Head and Neck
Circulating microRNA-21 (MIR-21) and phosphatase and tensin homolog (PTEN) are promising novel biomarkers for detection of oral squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Correlation between PTEN gene polymorphism and oral squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Detection of new PTEN/MMAC1 mutations in head and neck squamous cell carcinomas with loss of chromosome 10.
Squamous Cell Carcinoma of Head and Neck
Genotypic analysis of tumor suppressor genes PTEN/MMAC1 and p53 in head and neck squamous cell carcinomas.
Squamous Cell Carcinoma of Head and Neck
Hypoxic niches are endowed with a protumorigenic mechanism that supersedes the protective function of PTEN.
Squamous Cell Carcinoma of Head and Neck
Immunohistochemical expression of phosphatase and tensin homolog in histologic gradings of oral squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Loss of heterozygosity at 10q in tumors of the upper respiratory tract is associated with poor prognosis.
Squamous Cell Carcinoma of Head and Neck
Mammalian target of rapamycin inhibitors as possible adjuvant therapy for microscopic residual disease in head and neck squamous cell cancer.
Squamous Cell Carcinoma of Head and Neck
Phosphatase and tensin homolog overexpression decreases proliferation and invasion and increases apoptosis in oral squamous cell carcinoma cells.
Squamous Cell Carcinoma of Head and Neck
Phosphorylated mammalian target of rapamycin is associated with an adverse outcome in oral squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
PI3K/AKT/mTOR signaling as a molecular target in head and neck cancer.
Squamous Cell Carcinoma of Head and Neck
Poor prognostic clinicopathologic features correlate with VEGF expression but not with PTEN expression in squamous cell carcinoma of the larynx.
Squamous Cell Carcinoma of Head and Neck
PTEN and ?-SMA Expression and Diagnostic Role in Oral Submucous Fibrosis and Oral Squamous Cell Carcinoma with Concomitant Oral Submucous Fibrosis.
Squamous Cell Carcinoma of Head and Neck
PTEN Is Associated With Worse Local Control in Early Stage Supraglottic Laryngeal Cancer Treated With Radiotherapy.
Squamous Cell Carcinoma of Head and Neck
[Mutation and expression of tumor suppressor gene phosphatase and tensin homolog deleted in chromosome 10 in oral squamous cell carcinoma.]
Starvation
Increased expression of Mcl-1 is required for protection against serum starvation in phosphatase and tensin homologue on chromosome 10 null mouse embryonic fibroblasts, but repression of Bim is favored in human glioblastomas.
Stomach Neoplasms
Acetyl-11-keto-?-boswellic acid inhibits proliferation and induces apoptosis of gastric cancer cells through the phosphatase and tensin homolog /Akt/ cyclooxygenase-2 signaling pathway.
Stomach Neoplasms
Activation of phospholipase C-?1 and translocation of phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase contribute to GL-V9-induced apoptosis in human gastric cancer cells.
Stomach Neoplasms
An increase in galectin-3 causes cellular unresponsiveness to IFN-?-induced signal transduction and growth inhibition in gastric cancer cells.
Stomach Neoplasms
Analysis of PTEN/MMAC1 alterations in aerodigestive tract tumors.
Stomach Neoplasms
CDX2 inhibits invasion and migration of gastric cancer cells by phosphatase and tensin homologue deleted from chromosome 10/Akt signaling pathway.
Stomach Neoplasms
CircPSMC3 suppresses the proliferation and metastasis of gastric cancer by acting as a competitive endogenous RNA through sponging miR-296-5p.
Stomach Neoplasms
Concomitant modulation of PTEN and Livin in gastric cancer treatment.
Stomach Neoplasms
Downregulation of MicroRNA-147 Inhibits Cell Proliferation and Increases the Chemosensitivity of Gastric Cancer Cells to 5-Fluorouracil by Directly Targeting PTEN.
Stomach Neoplasms
Downregulation of microRNA-193-3p inhibits tumor proliferation migration and chemoresistance in human gastric cancer by regulating PTEN gene.
Stomach Neoplasms
Enhanced antiproliferative activity of antibody-functionalized polymeric nanoparticles for targeted delivery of anti-miR-21 to HER2 positive gastric cancer.
Stomach Neoplasms
High miR-718 Suppresses Phosphatase and Tensin Homolog (PTEN) Expression and Correlates to Unfavorable Prognosis in Gastric Cancer.
Stomach Neoplasms
Increased Gastric Cancer Risk with PTEN IVS4 Polymorphism in a Turkish Population.
Stomach Neoplasms
Low expression of PTEN is essential for maintenance of a malignant state in human gastric adenocarcinoma via upregulation of p?AURKA mediated by activation of AURKA.
Stomach Neoplasms
Micro-RNA 205-5p is Involved in the Progression of Gastric Cancer and Targets Phosphatase and Tensin Homolog (PTEN) in SGC-7901 Human Gastric Cancer Cells.
Stomach Neoplasms
Microrna-136 promotes proliferation and invasion ingastric cancer cells through Pten/Akt/P-Akt signaling pathway.
Stomach Neoplasms
MicroRNA-197 inhibits gastric cancer progression by directly targeting metadherin.
Stomach Neoplasms
MicroRNA-21 stimulates gastric cancer growth and invasion by inhibiting the tumor suppressor effects of programmed cell death protein 4 and phosphatase and tensin homolog.
Stomach Neoplasms
NF-kappaB-dependent microRNA-425 upregulation promotes gastric cancer cell growth by targeting PTEN upon IL-1? induction.
Stomach Neoplasms
Polymorphisms in lncRNA PTENP1 and the Risk of Gastric Cancer in a Chinese Population.
Stomach Neoplasms
Prognostic importance of PTEN, EGFR, HER-2, and IGF-1R in gastric cancer patients treated with postoperative chemoradiation
Stomach Neoplasms
PTEN, a Barrier for Proliferation and Metastasis of Gastric Cancer Cells: From Molecular Pathways to Targeting and Regulation.
Stomach Neoplasms
PTEN/MMAC1 enhances the growth inhibition by anticancer drugs with downregulation of IGF-II expression in gastric cancer cells.
Stomach Neoplasms
Suppression of gastric cancer growth by adenovirus-mediated transfer of the PTEN gene.
Stomach Neoplasms
Vitamin D stimulates apoptosis in gastric cancer cells in synergy with trichostatin A /sodium butyrate-induced and 5-aza-2'-deoxycytidine-induced PTEN upregulation.
Stomach Ulcer
Effect of the IGF-1/PTEN/Akt/FoxO signaling pathway on the development and healing of water immersion and restraint stress-induced gastric ulcers in rats.
Stroke
Bisperoxovanadium mediates neuronal protection through inhibition of PTEN and activation of PI3K/AKT-mTOR signaling following traumatic spinal injuries.
Stroke
Delayed administration of a PTEN inhibitor BPV improves functional recovery after experimental stroke.
Stroke
Dual neuroprotective signaling mediated by downregulating two distinct phosphatase activities of PTEN.
Stroke
MicroRNA cluster miR-17-92 Cluster in Exosomes Enhance Neuroplasticity and Functional Recovery After Stroke in Rats.
Sturge-Weber Syndrome
Clinical and sonographic features of pediatric soft-tissue vascular anomalies part 2: vascular malformations.
Sturge-Weber Syndrome
Congenital Limb Overgrowth Syndromes Associated with Vascular Anomalies.
Subarachnoid Hemorrhage
Administration of a PTEN inhibitor BPV(pic) attenuates early brain injury via modulating AMPA receptor subunits after subarachnoid hemorrhage in rats.
Subarachnoid Hemorrhage
Treatment with sodium orthovanadate reduces blood-brain barrier disruption via phosphatase and tensin homolog deleted on chromosome 10 (PTEN) phosphorylation in experimental subarachnoid hemorrhage.
Telangiectasia, Hereditary Hemorrhagic
Parkes Weber syndrome, vein of Galen aneurysmal malformation, and other fast-flow vascular anomalies are caused by RASA1 mutations.
Telangiectasis
Parkes Weber syndrome, vein of Galen aneurysmal malformation, and other fast-flow vascular anomalies are caused by RASA1 mutations.
Telangiectasis
Pathogenic and likely pathogenic variants in PALB2, CHEK2, and other known breast cancer susceptibility genes among 1054 BRCA-negative Hispanics with breast cancer.
Testicular Neoplasms
Dysregulation of WNT/CTNNB1 and PI3K/AKT signaling in testicular stromal cells causes granulosa cell tumor of the testis.
Thymoma
A common variation of the PTEN gene is associated with peripheral insulin resistance.
Thymoma
An Immunohistochemical Study of the PTEN/AKT Pathway Involvement in Canine and Feline Mammary Tumors.
Thymoma
Cardioprotective MicroRNAs.
Thymoma
Combined Effects of Genetic Variants of the PTEN, AKT1, MDM2 and p53 Genes on the Risk of Nasopharyngeal Carcinoma.
Thymoma
Expression Patterns of Growth and Survival Genes with Prognostic Implications in Advanced Pancreatic Cancer.
Thymoma
Genetic variations in the PI3K/PTEN/AKT/mTOR pathway are associated with clinical outcomes in esophageal cancer patients treated with chemoradiotherapy.
Thymoma
Green tea polyphenols improve cardiac muscle mRNA and protein levels of signal pathways related to insulin and lipid metabolism and inflammation in insulin-resistant rats.
Thymoma
Metastasis suppressor protein 1 regulated by PTEN suppresses invasion, migration, and EMT of gastric carcinoma by inactivating PI3K/AKT signaling.
Thymoma
microRNA-22 attenuates neuronal cell apoptosis in a cell model of traumatic brain injury.
Thymoma
miR-144/451 Promote Cell Proliferation via Targeting PTEN/AKT Pathway in Insulinomas.
Thymoma
PRDX1 activates autophagy via the PTEN-AKT signaling pathway to protect against cisplatin-induced spiral ganglion neuron damage.
Thyroid Cancer, Papillary
Mutation analysis of PTEN/MMAC 1 in sporadic thyroid tumors.
Thyroid Neoplasms
Balancing Proliferation and Connectivity in PTEN-associated Autism Spectrum Disorder.
Thyroid Neoplasms
Frequent Gastrointestinal Polyps and Colorectal Adenocarcinomas in a Prospective Series of PTEN Mutation Carriers.
Thyroid Neoplasms
miR-17-5p knockdown inhibits proliferation, autophagy and promotes apoptosis in thyroid cancer via targeting PTEN.
Thyroid Neoplasms
Mutation analysis of PTEN/MMAC 1 in sporadic thyroid tumors.
Thyroid Neoplasms
PTEN Lipid Phosphatase Activity and Proper Subcellular Localization Are Necessary and Sufficient for Down-Regulating AKT Phosphorylation in the Nucleus in Cowden Syndrome.
Thyroid Neoplasms
PTEN Promoter Methylation in Sporadic Thyroid Carcinomas.
Thyroid Neoplasms
Thyroid involvement in two patients with Bannayan-Riley-Ruvalcaba syndrome.
Thyroid Nodule
Diagnostic significance of DNA methylation of PTEN and DAPK in thyroid tumors.
Thyroiditis
Thyroid involvement in two patients with Bannayan-Riley-Ruvalcaba syndrome.
Tics
Different response of human glioma tumor-initiating cells to epidermal growth factor receptor kinase inhibitors.
Tics
Selective targeting of radiation-resistant tumor-initiating cells.
Tics
Wnt/?-catenin activation and macrophage induction during liver cancer development following steatosis.
Tongue Neoplasms
Preventive Effect of Lactobacillus fermentum CQPC08 on 4-Nitroquineline-1-Oxide Induced Tongue Cancer in C57BL/6 Mice.
transaldolase deficiency
Systemic lupus erythematosus in a girl with PTEN variant and transaldolase deficiency: a novel phenotype.
Tremor
Multifocal demyelinating motor neuropathy and hamartoma syndrome associated with a de novo PTEN mutation.
Triple Negative Breast Neoplasms
DCAF13 promotes triple-negative breast cancer metastasis by mediating DTX3 mRNA degradation.
Triple Negative Breast Neoplasms
Exploiting Chromosomal Instability of PTEN-Deficient Triple-Negative Breast Cancer Cell Lines for the Sensitization against PARP1 Inhibition in a Replication-Dependent Manner.
Triple Negative Breast Neoplasms
Non-Specific Blocking of miR-17-5p Guide Strand in Triple Negative Breast Cancer Cells by Amplifying Passenger Strand Activity.
Triple Negative Breast Neoplasms
PI3K inhibition enhances the anti-tumor effect of eribulin in triple negative breast cancer.
Triple Negative Breast Neoplasms
Treatment of triple-negative metastatic breast cancer: toward individualized targeted treatments or chemosensitization?
Tuberous Sclerosis
Akt and mTORC1 Have Different Roles During Liver Tumorigenesis in Mice.
Tuberous Sclerosis
Developmental regulation of the activation of signaling components leading to translation initiation in skeletal muscle of neonatal pigs.
Tuberous Sclerosis
Dysregulation of Mammalian Target of Rapamycin Signaling in Mouse Models of Autism.
Tuberous Sclerosis
Finding a better drug for epilepsy: the mTOR pathway as an antiepileptogenic target.
Tuberous Sclerosis
Immunohistochemical Analysis of mTOR Pathway-Related Proteins in Kaposiform Hemangioendothelioma.
Tuberous Sclerosis
Macrophage-derived extracellular vesicles mediate smooth muscle hyperplasia: role of altered miRNA cargo in response to HIV infection and substance abuse.
Tuberous Sclerosis
mTOR, a Potential Target to Treat Autism Spectrum Disorder.
Tuberous Sclerosis
Pancreatic endocrine tumors: expression profiling evidences a role for AKT-mTOR pathway.
Tuberous Sclerosis
Plasticity and mTOR: towards restoration of impaired synaptic plasticity in mTOR-related neurogenetic disorders.
Tuberous Sclerosis
Postnatal ontogeny of skeletal muscle protein synthesis in pigs.
Tuberous Sclerosis
Role of AMP-Activated Protein Kinase in Cancer Therapy.
Tuberous Sclerosis
Targeting phosphatidylinositol 3 kinase (PI3K)-Akt beyond rapalogs.
Tuberous Sclerosis
Targeting phosphoinositide 3-kinase: moving towards therapy.
Tuberous Sclerosis
The mTORC1 effectors S6K1 and 4E-BP play different roles in CNS axon regeneration.
Tuberous Sclerosis
Transforming Growth Factor-? Signaling Participates in the Maintenance of the Primordial Follicle Pool in the Mouse Ovary.
Tuberous Sclerosis
Unrestrained mammalian target of rapamycin complexes 1 and 2 increase expression of phosphatase and tensin homolog deleted on chromosome 10 to regulate phosphorylation of Akt kinase.
Urinary Bladder Neoplasms
?-elemene induced anticancer effect in bladder cancer through upregulation of PTEN and suppression of AKT phosphorylation.
Urinary Bladder Neoplasms
Bladder cancer cell?secreted exosomal miR?21 activates the PI3K/AKT pathway in macrophages to promote cancer progression.
Urinary Bladder Neoplasms
Genome-Wide Screen of miRNAs and Targeting mRNAs Reveals the Negatively Regulatory Effect of miR-130b-3p on PTEN by PI3K and Integrin ?1 Signaling Pathways in Bladder Carcinoma.
Urinary Bladder Neoplasms
Heterogeneity of PTEN and PPAR-? in cancer and their prognostic application to bladder cancer.
Urinary Bladder Neoplasms
Inhibition of cholesterol metabolism underlies synergy between mTOR pathway inhibition and chloroquine in bladder cancer cells.
Urinary Bladder Neoplasms
Long noncoding RNA MAGI2-AS3 inhibits bladder cancer progression through MAGI2/PTEN/epithelial-mesenchymal transition (EMT) axis.
Urinary Bladder Neoplasms
MicroRNA-21 could be a molecular marker to predict the recurrence of nonmuscle invasive bladder cancer.
Urinary Bladder Neoplasms
MicroRNA-34a inhibits bladder cancer cell migration and invasion, and upregulates PTEN expression.
Urinary Bladder Neoplasms
microRNA-495 promotes bladder cancer cell growth and invasion by targeting phosphatase and tensin homolog.
Urinary Bladder Neoplasms
Point mutation and homozygous deletion of PTEN/MMAC1 in primary bladder cancers.
Urinary Bladder Neoplasms
Somatic mutation of PTEN in bladder carcinoma.
Uterine Cervical Neoplasms
Correlation Between Single Nucleotide Polymorphisms of an miRNA Binding Site in the 3'UTR of PTEN and Risk of Cervical Cancer Among the Han Chinese.
Uterine Cervical Neoplasms
Folic acid conjugated polymeric micelles loaded with a curcumin difluorinated analog for targeting cervical and ovarian cancers.
Uterine Cervical Neoplasms
Long noncoding RNA ALOX12-AS1 inhibits cervical cancer cells proliferation via targeting miR-3171.
Uterine Cervical Neoplasms
MicroRNA?10a enhances the metastatic potential of cervical cancer cells by targeting phosphatase and tensin homologue.
Uterine Cervical Neoplasms
MicroRNA?494 promotes cervical cancer proliferation through the regulation of PTEN.
Uterine Cervical Neoplasms
Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in cervical cancer.
Uterine Cervical Neoplasms
Nuclear factor-?B-dependent microRNA-130a upregulation promotes cervical cancer cell growth by targeting phosphatase and tensin homolog.
Uterine Cervical Neoplasms
Serum miR-486-5p as a diagnostic marker in cervical cancer: with investigation of potential mechanisms.
Uterine Cervical Neoplasms
Silymarin Inhibits Cervical Cancer Cell Through an Increase of Phosphatase and Tensin Homolog.
Uterine Neoplasms
Abnormal structure and expression of PTEN/MMAC1 gene in human uterine cancers.
Uveitis, Intermediate
Intermediate uveitis in a child with phosphatase and tensin homolog gene mutation and Bannayan-Riley-Ruvalcaba syndrome.
Vaccinia
Structural and functional analysis of PTPMT1, a phosphatase required for cardiolipin synthesis.
Vascular Malformations
Clinical and sonographic features of pediatric soft-tissue vascular anomalies part 2: vascular malformations.
Vitiligo
Mesenchymal stem cells promote human melanocytes proliferation and resistance to apoptosis through PTEN pathway in vitiligo.
von Hippel-Lindau Disease
Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis.
Werner Syndrome
Molecular mutation characteristics of mismatch and homologous recombination repair genes in gastrointestinal cancer.
Wilms Tumor
Aberrant expression and mechanism of miR-130b-3p/phosphatase and tensin homolog in nephroblastoma in children.
Wilms Tumor
Loss of PTEN/MMAC1 activity is a rare and late event in the pathogenesis of nephroblastomas.
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3.1.3.67 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
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The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). 
