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Information on EC 3.1.3.64 - phosphatidylinositol-3-phosphatase and Organism(s) Caenorhabditis elegans

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EC Tree
     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.3 Phosphoric-monoester hydrolases
                3.1.3.64 phosphatidylinositol-3-phosphatase
IUBMB Comments
This enzyme still works when the 2,3-bis(acyloxy)propyl group is removed, i.e., it hydrolyses Ins(1,3)P2 to Ins-1-P.
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This record set is specific for:
Caenorhabditis elegans
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Word Map
The taxonomic range for the selected organisms is: Caenorhabditis elegans
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
ptdins3p, myotubularin, mtmr2, mtmr3, mtmr14, mtmr6, mtmr4, mtmr13, mtmr7, myotubularin-related protein, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D-myo-inositol 1,3-bisphosphate 3-phosphohydrolase
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-
-
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inositol 1,3-bisphosphate phosphatase
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-
-
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inositol-1,3-bisphosphate 3-phosphatase
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-
-
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inositol-polyphosphate 3-phosphatase
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-
-
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phosphatase, phosphatidylinositol 3-
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-
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phosphatidyl-3-phosphate 3-phosphohydrolase
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-
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phosphoinositide 3-phosphatase
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-
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PtdIns 3-phosphatase
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-
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-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of phosphoric ester
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PATHWAY SOURCE
PATHWAYS
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-, -, -
SYSTEMATIC NAME
IUBMB Comments
1-phosphatidyl-1D-myo-inositol-3-phosphate 3-phosphohydrolase
This enzyme still works when the 2,3-bis(acyloxy)propyl group is removed, i.e., it hydrolyses Ins(1,3)P2 to Ins-1-P.
CAS REGISTRY NUMBER
COMMENTARY hide
122653-77-4
formerly, EC 3.1.3.65
124248-47-1
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
phosphatidylinositol 3,5-bisphosphate + H2O
phosphatidylinositol 5-phosphate + phosphate
show the reaction diagram
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-
-
?
phosphatidylinositol 3-phosphate + H2O
phosphatidylinositol + phosphate
show the reaction diagram
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-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
-
inactivating mtm-1, blocks phagosome maturation
physiological function
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
MTMR1_CAEEL
588
0
67593
Swiss-Prot
other Location (Reliability: 2)
MTMR3_CAEEL
1006
0
113614
Swiss-Prot
other Location (Reliability: 2)
MTMR6_CAEEL
676
0
77309
Swiss-Prot
other Location (Reliability: 2)
G5EBF2_CAEEL
782
0
88304
TrEMBL
other Location (Reliability: 4)
MTMR9_CAEEL
569
0
64537
Swiss-Prot
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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Bolis, A.; Zordan, P.; Coviello, S.; Bolino, A.
Myotubularin-related (MTMR) phospholipid phosphatase proteins in the peripheral nervous system
Mol. Neurobiol.
35
308-316
2007
Chlorocebus aethiops, Caenorhabditis elegans, Caenorhabditis elegans (Q965W9), Homo sapiens, Mus musculus, Mus musculus (Q9Z2C4), Rattus norvegicus
Manually annotated by BRENDA team
Lu, N.; Shen, Q.; Mahoney, T.R.; Neukomm, L.J.; Wang, Y.; Zhou, Z.
Two PI 3-kinases and one PI 3-phosphatase together establish the cyclic waves of phagosomal PtdIns(3)P critical for the degradation of apoptotic cells
PLoS Biol.
10
e1001245
2012
Caenorhabditis elegans
Manually annotated by BRENDA team