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Information on EC 3.1.3.48 - protein-tyrosine-phosphatase and Organism(s) Rattus norvegicus
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EC Tree
3.1.3.48 protein-tyrosine-phosphataseIUBMB Comments
Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2, non-specific protein-tyrosine kinase.
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Word Map
- 3.1.3.48
- pp2a
- mapks
- autoimmune
- erk
- cyclin
- leukemia
- endothelial
- ras
-
signal-regulated
- lysosomal
-
okadaic
- t-cells
- metastasis
-
checkpoint
- sirna
- obesity
- myeloid
- 3-kinase
- adaptor
- arthritis
- vanadate
- stat3
- tumorigenesis
- prostate
- mellitus
- phosphatidylinositol
-
cyclin-dependent
- c-jun
- pkc
-
rheumatoid
-
tyrosine-phosphorylated
-
hyperphosphorylation
-
nonreceptor
- chk1
-
cytochemical
- autophosphorylation
-
receptor-like
- genistein
- irs-1
-
insulin-stimulated
- phosphopeptide
-
tartrate-resistant
- grb2
- c-src
- jak2
- fyn
- paxillin
- substrate-1
-
myelomonocytic
-
polo-like
- medicine
- pharmacology
- diagnostics
- drug development
The taxonomic range for the selected organisms is: Rattus norvegicus
The enzyme appears in selected viruses and cellular organisms
The enzyme appears in selected viruses and cellular organisms
Synonyms
ptp1b, protein tyrosine phosphatase, shp-1, shp-2, tyrosine phosphatase, protein phosphatase 2a, acid phosphatase activity, mkp-1, cdc25a, ptpn22, 
more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
70Z-SHP
-
-
-
-
Brain-derived phosphatase
-
-
-
-
BVP
-
-
-
-
CD148 antigen
-
-
-
-
CD45
-
-
-
-
CD45 antigen
-
-
-
-
Cdc25-like protein
-
-
-
-
CDK2-associated dual specificity phosphatase
-
-
-
-
Ch-1PTPase
-
-
-
-
CPTP1
-
-
-
-
DLAR
-
-
-
-
Dual specificity phosphatase Cdc25A
-
-
-
-
Dual specificity phosphatase Cdc25B
-
-
-
-
Dual specificity phosphatase Cdc25C
-
-
-
-
Dual specificity protein phosphatase hVH1
-
-
-
-
Dual specificity protein phosphatase hVH2
-
-
-
-
Dual specificity protein phosphatase hVH3
-
-
-
-
Dual specificity protein phosphatase PYST1
-
-
-
-
Dual specificity protein phosphatase PYST2
-
-
-
-
Dual specificity protein phosphatase VHR
-
-
-
-
Dual-specificity tyrosine phosphatase TS-DSP6
-
-
-
-
Dual-specificity tyrosine phosphatase YVH1
-
-
-
-
ES cell phosphatase
-
-
-
-
HCP
-
-
-
-
Hematopoietic cell protein-tyrosine phosphatase
-
-
-
-
Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP
-
-
-
-
Hematopoietic protein-tyrosine phosphatase
-
-
-
-
HEPTP
-
-
-
-
HPTP beta-like tyrosine phosphatase
-
-
-
-
HPTP eta
-
-
-
-
hPTPE1
-
-
-
-
ICAAR
-
-
-
-
Islet cell autoantigen related protein
-
-
-
-
kinase associated phosphatase
-
-
-
-
L-CA
-
-
-
-
Late protein H1
-
-
-
-
LCA
-
-
-
-
LCA-related phosphatase
-
-
-
-
Leukocyte antigen related
-
-
-
-
Low molecular weight cytosolic acid phosphatase
-
-
-
-
LRP
-
-
-
-
Lymphoid phosphatase
-
-
-
-
LyP
-
-
-
-
M1851
-
-
-
-
MAP-kinase phosphatase CPG21
-
-
-
-
MEG
-
-
-
-
Mitosis initiation protein
-
-
-
-
Mitosis initiation protein MIH1
-
-
-
-
Mitotic inducer homolog
-
-
-
-
MKP-1 like protein tyrosine phosphatase
-
-
-
-
MPTP
-
-
-
-
MPTP-PEST
-
-
-
-
NC-PTPCOM1
-
-
-
-
Neural-specific protein-tyrosine phosphatase
-
-
-
-
ORF5
-
-
-
-
OST-PTP
-
-
-
-
P19-PTP
-
-
-
-
P80
-
-
-
-
PC12-PTP1
-
-
-
-
Phogrin
-
-
-
-
Phosphacan
-
-
-
-
phosphatase, phosphoprotein (phosphotyrosine)
-
-
-
-
phosphatase, phosphotyrosine
-
-
-
-
phosphoprotein phosphatase (phosphotyrosine)
-
-
-
-
phosphotyrosine histone phosphatase
-
-
-
-
phosphotyrosine phosphatase
-
-
-
-
Phosphotyrosine phosphatase 13
-
-
-
-
phosphotyrosine protein phosphatase
-
-
-
-
phosphotyrosylprotein phosphatase
-
-
-
-
protein phosphotyrosine phosphatase
-
-
-
-
Protein tyrosine phosphatase-NP
-
-
-
-
Protein-protein-tyrosine phosphatase HA2
-
-
-
-
Protein-tyrosine phosphatase 1B
-
-
-
-
Protein-tyrosine phosphatase 1C
-
-
-
-
Protein-tyrosine phosphatase 1E
-
-
-
-
Protein-tyrosine phosphatase 2C
-
-
-
-
Protein-tyrosine phosphatase 2E
-
-
-
-
Protein-tyrosine phosphatase 3CH134
-
-
-
-
Protein-tyrosine phosphatase CL100
-
-
-
-
Protein-tyrosine phosphatase D1
-
-
-
-
Protein-tyrosine phosphatase ERP
-
-
-
-
Protein-tyrosine phosphatase G1
-
-
-
-
Protein-tyrosine phosphatase H1
-
-
-
-
Protein-tyrosine phosphatase LC-PTP
-
-
-
-
Protein-tyrosine phosphatase MEG1
-
-
-
-
Protein-tyrosine phosphatase MEG2
-
-
-
-
Protein-tyrosine phosphatase P19
-
-
-
-
Protein-tyrosine phosphatase PCPTP1
-
-
-
-
Protein-tyrosine phosphatase pez
-
-
-
-
Protein-tyrosine phosphatase PTP-RL10
-
-
-
-
Protein-tyrosine phosphatase PTP36
-
-
-
-
Protein-tyrosine phosphatase PTPL1
-
-
-
-
Protein-tyrosine phosphatase striatum-enriched
-
-
-
-
Protein-tyrosine phosphatase SYP
-
-
-
-
Protein-tyrosine-phosphatase SL
-
-
-
-
Protein-tyrosine-phosphate phosphohydrolase
-
-
-
-
PTP IA-2beta
-
-
-
-
PTP-1B
-
-
-
-
PTP-1C
-
-
-
-
PTP-1D
-
-
-
-
PTP-2C
-
-
-
-
PTP-BAS
-
-
-
-
PTP-E1
-
-
-
-
PTP-H1
-
-
-
-
PTP-HA2
-
-
-
-
PTP-NP
-
-
-
-
PTP-SH2beta
-
-
-
-
PTP1C
-
-
-
-
PTP1D
-
-
-
-
PTP2C
-
-
-
-
PTPase YVH1
-
-
-
-
PTPase-MEG1
-
-
-
-
PTPase-MEG2
-
-
-
-
PTPG1
-
-
-
-
PTPN6
-
-
-
-
PTPNE6
-
-
-
-
PY protein phosphatase
-
-
-
-
R-PTP-alpha
-
-
-
-
R-PTP-beta
-
-
-
-
R-PTP-delta
-
-
-
-
R-PTP-epsilon
-
-
-
-
R-PTP-eta
-
-
-
-
R-PTP-gamma
-
-
-
-
R-PTP-kappa
-
-
-
-
R-PTP-mu
-
-
-
-
R-PTP-zeta
-
-
-
-
Receptor-linked protein-tyrosine phosphatase 10D
-
-
-
-
Receptor-linked protein-tyrosine phosphatase 99A
-
-
-
-
RNA/RNP complex-intereracting phosphatase
-
-
-
-
ROL B protein
-
-
-
-
RPTPalpha
-
-
-
-
SH-PTP1
-
-
-
-
SH-PTP2
-
-
-
-
SH-PTP3
-
-
-
-
SHP
-
-
-
-
Small tyrosine phosphatase
-
-
-
-
Small, acidic phosphotyrosine protein phosphatase
-
-
-
-
STEP
STEP33
-
STEP is processed into a 33 kDa isoform by calpain-mediated cleavage, STEP33 retains catalytic activity but is unable to bind to phosphorylated ERK
String protein
-
-
-
-
Syp
-
-
-
-
T-cell protein-tyrosine phosphatase
-
-
-
-
T-DSP11
-
-
-
-
T200
-
-
-
-
TCPTP
Testis-and skeletal-muscle-specific DSP
-
-
-
-
tyrosine O-phosphate phosphatase
-
-
-
-
Tyrosine phosphatase CBPTP
-
-
-
-
tyrosylprotein phosphatase
-
-
-
-
[phosphotyrosine]protein phosphatase
-
-
-
-
STEP
-
-
-
-
TCPTP
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of phosphoric ester
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
protein-tyrosine-phosphate phosphohydrolase
Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2, non-specific protein-tyrosine kinase.
CAS REGISTRY NUMBER
COMMENTARY
79747-53-8
-
97162-86-2
-
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
4-methylumbelliferyl phosphate + H2O
4-methylumbelliferone + phosphate
-
-
-
-
?
phosphorylated ERK + H2O
ERK + phosphate
-
the cleavage of STEP leads to a catalytically active form, but this cleaved form no longer binds to and dephosphorylates its substrate phosphorylated ERK
-
-
?
phosphorylated extracellular signal-regulated kinase 1 + H2O
extracellular signal-regulated kinase 1 + phosphate
-
-
-
-
?
phosphorylated extracellular signal-regulated kinase 2 + H2O
extracellular signal-regulated kinase 2 + phosphate
-
-
-
-
?
[a protein]-tyrosine phosphate + H2O
[a protein]-tyrosine + phosphate
-
-
-
-
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
-
-
-
-
?
additional information
?
-
-
acts specifically on phosphorylated tyrosine
-
?
additional information
?
-
-
protein-tyrosine phosphatases are signaling molecules that are involved in numerous cellular mechanisms such as cell growth and proliferation, cell cycle regulation, and cytoskeletal integrity
-
-
?
additional information
?
-
-
LAR, PTPalpha and PTP1B may act upon cell surface insulin receptors
-
?
additional information
?
-
-
enzyme activity is correlated with sperm thiol status and tyrosine phosphorylation of sperm proteins during maturation is promoted by thiol oxidation and diminished enzyme
-
-
?
additional information
?
-
-
enzyme isoform Shp2 is required for complete activation of mitogen-activated protein kinases MAPKs by brain-derived neurotropic factor
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
[a protein]-tyrosine phosphate + H2O
[a protein]-tyrosine + phosphate
-
-
-
-
?
additional information
?
-
-
protein-tyrosine phosphatases are signaling molecules that are involved in numerous cellular mechanisms such as cell growth and proliferation, cell cycle regulation, and cytoskeletal integrity
-
-
?
additional information
?
-
-
LAR, PTPalpha and PTP1B may act upon cell surface insulin receptors
-
?
additional information
?
-
-
enzyme activity is correlated with sperm thiol status and tyrosine phosphorylation of sperm proteins during maturation is promoted by thiol oxidation and diminished enzyme
-
-
?
additional information
?
-
-
enzyme isoform Shp2 is required for complete activation of mitogen-activated protein kinases MAPKs by brain-derived neurotropic factor
-
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
JTT-551
-
i.e. monosodium (([5-(1,1-dimethylethyl)thiazol-2-yl]methyl) ([(4-(4-[4-(1-propylbutyl)phenoxy]methyl)phenyl)thiazol-2-yl]methyl)amino)acetate, a specific protein tyrosine phosphatase 1B inhibitor in vitro and in vivo, mixed-type inhibition mode versus PTPB1, overview. The inhibitor shows a hypoglycaemic effect in rat L6 cells, overview
N-(4-([(6-methoxy-1,3-benzothiazol-2-yl)amino]sulfonyl)phenyl)acetamide
-
-
N-(6-ethoxy-1,3-benzothiazol-2-yl)-4-nitrobenzene sulfonamide
-
linear mixed-type inhibition, shows in vivo antihyperglycemic activity
N-(6-methyl-1,3-benzothiazol-2-yl)-4-nitrobenzenesulfonamide
-
linear mixed-type inhibition, shows in vivo antihyperglycemic activity
potassium bisperoxo(1,10-phenanthroline)oxovanadate(V)
-
i.e. [bpV(phen)], the peroxovanadium compound is a stable, potent and selective protein tyrosine phosphatase inhibitor. It protects dorsal column sensory axons and white matter and rescues sensory-evoked potentials in vivo after treatement with PTP or spinal cord injury, overview
additional information
-
in absence of externally added Ca2+, no effect of ethylene glycol bis(2-amino-ethylether) N,N,N,N-tetracetic acid or trifluoperazine. Not inhibitory: okadaic acid
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
pI VALUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
7.2
-
calculated, recombinant catalytic domain of protein tyrosine phosphatase ny, His-tag free
7.3
-
isoelectric focusing, recombinant catalytic domain of protein tyrosine phosphatase ny, His-tag free
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
alternative splicing produces 3 isoforms: PTPxi-A, the full-length form, PTPxi-B, the short form and PTPxi-S an extracellular variant
-
-
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
-
epididymal spermatozoon, changes in thiol status during sperm maturation affect enzyme protein levels and activity. Tyrosine phosphorylation is significantly increased in several sperm tails during maturation. Enzyme activity is higher in the caput spermatozoa, which have a high thiol content, than in the cauda spermatozoa, with low thiol content
-
in global cerebral ischemia STEP mRNA is selectively down-regulated in brain areas susceptible to ischemic damage, while in regions of the brain that are relatively resistant to ischemic damage STEP mRNA levels are increased
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
-
isoforms STEP46 and STEP33 are found predominantly in the cytoplasmic fraction
-
there is a significant processing of STEP after ischemia to generate a novel species, STEP33, resulting in a redistribution of STEP from membrane-bound to soluble compartments
-
additional information
-
detailed study on subcellular distribution of isozymes
-
-
the PTPase family contains both cell surface transmembrane receptor forms and cytolasmic nonreceptor forms. The receptor forms generally have an extracellular domain, a single transmembrane region, and one or two cytoplasmic PTPase domains. The intracellular PTPases contain a single catalytic domain and various amino- or carboxy-terminal extensions including SH2-domains that may have targeting or regulatory functions. The catalytic domain is the only structural element with an amino acid sequence identical among all PTPases from bacteria to mammals
-
the majority of STEP61 is found in membrane-bound compartments
-
the PTPase family contains both cell surface transmembrane receptor forms and cytoplasmic nonreceptor forms. The receptor forms generally have an extracellular domain, a single transmembrane region, and one or two cytoplasmic PTPase domains. The intracellular PTPases contain a single catalytic domain and various amino- or carboxy-terminal extensions including SH2-domains that may have targeting or regulatory functions. The catalytic domain is the only structural element with an amino acid sequence identical among all PTPases from bacteria to mammals
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
malfunction
-
protein tyrosine phosphatases inactivate neurotrophic factor receptors and downstream intracellular signaling molecules causing neurodegeneration and loss of sensoric functions, overview
physiological function
-
protein tyrosine phosphatase-PEST regulates mast cell-activating signals in protein tyrosine phosphatase activity-dependent and -independent manners
additional information
-
small-molecule protein tyrosine phosphatase inhibition is a neuroprotective treatment after spinal cord injury in adult rats
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). EPM2A_RAT
331
0
37144
Swiss-Prot
Mitochondrion (Reliability: 4)
PPAC_RAT
158
0
18152
Swiss-Prot
other Location (Reliability: 3)
PPAP_RAT
381
0
43739
Swiss-Prot
Secretory Pathway (Reliability: 1)
DUS26_RAT
211
0
23947
Swiss-Prot
Mitochondrion (Reliability: 2)
CDKN3_RAT
212
0
23774
Swiss-Prot
other Location (Reliability: 1)
PTPRA_RAT
796
1
90260
Swiss-Prot
Secretory Pathway (Reliability: 1)
PTPRC_RAT
1273
2
143269
Swiss-Prot
Secretory Pathway (Reliability: 1)
PTPRE_RAT
699
1
80734
Swiss-Prot
Secretory Pathway (Reliability: 1)
PTPRF_RAT
1898
1
211494
Swiss-Prot
Secretory Pathway (Reliability: 2)
SSH3_RAT
652
0
72071
Swiss-Prot
Mitochondrion (Reliability: 3)
PTPM1_RAT
193
0
21886
Swiss-Prot
Secretory Pathway (Reliability: 5)
PTPR2_RAT
1004
0
111863
Swiss-Prot
Secretory Pathway (Reliability: 2)
DUS4_RAT
395
0
43187
Swiss-Prot
other Location (Reliability: 2)
DUS5_RAT
384
0
42094
Swiss-Prot
Mitochondrion (Reliability: 5)
DUS6_RAT
381
0
42319
Swiss-Prot
other Location (Reliability: 2)
DUS7_RAT
419
0
45067
Swiss-Prot
Mitochondrion (Reliability: 4)
MPIP1_RAT
525
0
59218
Swiss-Prot
other Location (Reliability: 5)
MPIP2_RAT
574
0
64287
Swiss-Prot
Mitochondrion (Reliability: 5)
PGP_RAT
321
0
34601
Swiss-Prot
other Location (Reliability: 2)
PTN5_RAT
369
0
42366
Swiss-Prot
other Location (Reliability: 1)
PTN6_RAT
613
0
69578
Swiss-Prot
other Location (Reliability: 4)
PTN7_RAT
359
0
40314
Swiss-Prot
Mitochondrion (Reliability: 5)
PTN9_RAT
593
0
67962
Swiss-Prot
other Location (Reliability: 2)
DUS29_RAT
215
0
24073
Swiss-Prot
other Location (Reliability: 2)
MTMR3_RAT
1194
0
133500
Swiss-Prot
other Location (Reliability: 3)
PTPRR_RAT
656
1
73907
Swiss-Prot
Secretory Pathway (Reliability: 3)
PTPRS_RAT
1907
2
211931
Swiss-Prot
Secretory Pathway (Reliability: 2)
PTPRV_RAT
1711
0
187293
Swiss-Prot
Secretory Pathway (Reliability: 1)
PTPRZ_RAT
2316
1
255342
Swiss-Prot
Secretory Pathway (Reliability: 1)
DUS12_RAT
339
0
37196
Swiss-Prot
other Location (Reliability: 2)
DUS15_RAT
236
0
26309
Swiss-Prot
other Location (Reliability: 3)
PTN11_RAT
593
0
68033
Swiss-Prot
other Location (Reliability: 4)
TP4A1_RAT
173
0
19815
Swiss-Prot
Mitochondrion (Reliability: 4)
TP4A2_RAT
167
0
19127
Swiss-Prot
other Location (Reliability: 2)
DUS18_RAT
204
0
22754
Swiss-Prot
other Location (Reliability: 4)
DUS1_RAT
367
0
39541
Swiss-Prot
other Location (Reliability: 3)
PTPRQ_RAT
2302
1
256824
Swiss-Prot
Secretory Pathway (Reliability: 1)
PTN1_RAT
432
1
49674
Swiss-Prot
other Location (Reliability: 1)
PTN20_RAT
421
0
48580
Swiss-Prot
other Location (Reliability: 2)
PTN21_RAT
1175
0
133412
Swiss-Prot
Mitochondrion (Reliability: 2)
PTN23_RAT
1499
0
163454
Swiss-Prot
other Location (Reliability: 2)
PTN2_RAT
416
1
48446
Swiss-Prot
other Location (Reliability: 1)
F1LQS5_RAT
575
0
64786
TrEMBL
Mitochondrion (Reliability: 5)
A0A0G2K1N1_RAT
1505
2
168865
TrEMBL
Secretory Pathway (Reliability: 2)
F1MAG7_RAT
1380
2
155262
TrEMBL
other Location (Reliability: 4)
A0A8I5YC57_RAT
1188
1
134192
TrEMBL
Secretory Pathway (Reliability: 3)
A0A8I6AS60_RAT
558
0
60942
TrEMBL
other Location (Reliability: 3)
A5I9F0_RAT
1439
1
162183
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8I6AF61_RAT
212
0
23287
TrEMBL
other Location (Reliability: 2)
Q91WZ1_RAT
198
0
21582
TrEMBL
other Location (Reliability: 3)
O54857_RAT
403
0
47118
TrEMBL
other Location (Reliability: 2)
F1LP13_RAT
1442
1
161048
TrEMBL
Secretory Pathway (Reliability: 1)
Q66HJ7_RAT
796
1
90198
TrEMBL
Secretory Pathway (Reliability: 1)
F7F9Z5_RAT
1215
2
137396
TrEMBL
Mitochondrion (Reliability: 3)
A0A8I6A1C0_RAT
1390
1
156766
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8I5ZW41_RAT
1465
0
164416
TrEMBL
Secretory Pathway (Reliability: 1)
Q62884_RAT
1216
1
134276
TrEMBL
Secretory Pathway (Reliability: 2)
A0A8I5ZTX8_RAT
556
0
63240
TrEMBL
other Location (Reliability: 2)
A0A8I5ZVM7_RAT
1898
1
211397
TrEMBL
Secretory Pathway (Reliability: 2)
A0A8I6A077_RAT
561
0
61765
TrEMBL
other Location (Reliability: 4)
A0A8I6B402_RAT
616
0
66924
TrEMBL
other Location (Reliability: 1)
A0A0G2K163_RAT
623
0
70695
TrEMBL
other Location (Reliability: 3)
Q8CIN3_RAT
1426
1
159196
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0G2K2N0_RAT
1189
0
134786
TrEMBL
Mitochondrion (Reliability: 2)
A0A8I6ATT5_RAT
2309
1
254461
TrEMBL
Secretory Pathway (Reliability: 1)
M0RA99_RAT
1452
1
162885
TrEMBL
other Location (Reliability: 5)
A0A8I6A1V1_RAT
1912
1
214510
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8I5ZT59_RAT
595
0
67620
TrEMBL
other Location (Reliability: 4)
B0BNC1_RAT
158
0
17910
TrEMBL
other Location (Reliability: 3)
D3ZTG5_RAT
2004
1
224608
TrEMBL
Secretory Pathway (Reliability: 1)
Q4JFL6_RAT
1261
2
140353
TrEMBL
Secretory Pathway (Reliability: 2)
A0A0G2JVR0_RAT
783
0
88974
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8I6A599_RAT
873
0
100100
TrEMBL
Mitochondrion (Reliability: 2)
A0A0G2K3H0_RAT
1430
2
160586
TrEMBL
other Location (Reliability: 4)
D3ZVI5_RAT
592
0
64442
TrEMBL
other Location (Reliability: 2)
A0A8I6AF78_RAT
1898
1
211163
TrEMBL
other Location (Reliability: 5)
Q4JFL8_RAT
1501
2
168284
TrEMBL
Secretory Pathway (Reliability: 2)
A0A8I5ZTK5_RAT
1198
0
134004
TrEMBL
other Location (Reliability: 1)
F1LXJ9_RAT
1454
1
163031
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8I6AFY1_RAT
1216
0
135797
TrEMBL
other Location (Reliability: 3)
A0A0G2K064_RAT
612
0
69515
TrEMBL
other Location (Reliability: 2)
A0A0G2JT62_RAT
1907
1
212753
TrEMBL
Secretory Pathway (Reliability: 2)
A0A8I6AT43_RAT
1195
0
133343
TrEMBL
other Location (Reliability: 1)
G3V7L2_RAT
395
0
43173
TrEMBL
other Location (Reliability: 2)
G3V9L3_RAT
211
0
23115
TrEMBL
other Location (Reliability: 2)
A0A8I5ZPJ0_RAT
1469
1
165353
TrEMBL
Secretory Pathway (Reliability: 1)
Q64641_RAT
649
2
74173
TrEMBL
other Location (Reliability: 3)
G3V6B9_RAT
933
0
106555
TrEMBL
Mitochondrion (Reliability: 1)
A0A8I5Y7F9_RAT
411
1
47632
TrEMBL
other Location (Reliability: 1)
A0A0G2QC31_RAT
584
0
65173
TrEMBL
other Location (Reliability: 4)
M0RB22_RAT
1899
1
212856
TrEMBL
other Location (Reliability: 3)
Q4JFC6_RAT
1290
1
145468
TrEMBL
other Location (Reliability: 1)
A0A0G2K561_RAT
1341
1
149575
TrEMBL
other Location (Reliability: 2)
Q64622_RAT
68
1
8194
TrEMBL
Mitochondrion (Reliability: 5)
D3ZSL5_RAT
850
0
95215
TrEMBL
other Location (Reliability: 1)
A0A8I5Y8V2_RAT
1134
0
126290
TrEMBL
other Location (Reliability: 1)
A0A8I5ZVY1_RAT
1169
0
132411
TrEMBL
Mitochondrion (Reliability: 2)
A0A096MJA1_RAT
967
0
108937
TrEMBL
other Location (Reliability: 3)
D4ADT2_RAT
455
0
50896
TrEMBL
other Location (Reliability: 3)
Q64642_RAT
405
1
45629
TrEMBL
other Location (Reliability: 4)
A0A8I6GI01_RAT
618
0
71006
TrEMBL
Mitochondrion (Reliability: 3)
A0A8I5ZQN2_RAT
1506
1
169501
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8I6GIX5_RAT
549
0
62150
TrEMBL
Mitochondrion (Reliability: 5)
A0A0G2K3I9_RAT
145
0
15970
TrEMBL
other Location (Reliability: 1)
A0A8I6AAN8_RAT
1207
0
135122
TrEMBL
other Location (Reliability: 1)
A0A8I5ZXS3_RAT
339
0
38335
TrEMBL
Mitochondrion (Reliability: 5)
Q5XIN2_RAT
198
1
22499
TrEMBL
other Location (Reliability: 3)
Q499N7_RAT
597
0
67778
TrEMBL
other Location (Reliability: 4)
A0A8I6A3Q2_RAT
1205
0
134430
TrEMBL
other Location (Reliability: 2)
A0A8J8YBN3_RAT
805
1
91214
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8I5ZXU5_RAT
1916
2
213072
TrEMBL
Secretory Pathway (Reliability: 2)
A0A8I6AKL4_RAT
152
0
17298
TrEMBL
other Location (Reliability: 4)
A0A8I6GIT8_RAT
1140
0
129687
TrEMBL
Mitochondrion (Reliability: 2)
Q56A30_RAT
369
0
42338
TrEMBL
other Location (Reliability: 1)
G3V8T0_RAT
525
0
59076
TrEMBL
other Location (Reliability: 5)
A0A8I5ZUL2_RAT
935
0
106055
TrEMBL
other Location (Reliability: 2)
Z4YNF4_RAT
159
0
18215
TrEMBL
other Location (Reliability: 3)
Q64653_RAT
96
0
10922
TrEMBL
other Location (Reliability: 2)
A0A8I6A6R5_RAT
1920
1
215325
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8I5ZXQ0_RAT
1483
1
166584
TrEMBL
other Location (Reliability: 5)
F1LX86_RAT
639
0
69438
TrEMBL
other Location (Reliability: 1)
Q8CIN1_RAT
1168
1
130032
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8I6AMN9_RAT
572
0
62590
TrEMBL
other Location (Reliability: 1)
Q62988_RAT
142
0
16464
TrEMBL
other Location (Reliability: 1)
Q2YDV1_RAT
414
0
44780
TrEMBL
other Location (Reliability: 5)
Q5M863_RAT
318
0
34520
TrEMBL
other Location (Reliability: 5)
Q6LDZ3_RAT
962
1
109934
TrEMBL
other Location (Reliability: 3)
A0A0G2K1T5_RAT
533
0
58269
TrEMBL
other Location (Reliability: 3)
E9PTB7_RAT
1285
1
141629
TrEMBL
other Location (Reliability: 3)
A0A8I5Y9L5_RAT
730
1
84033
TrEMBL
Mitochondrion (Reliability: 3)
Q6UN47_RAT
531
0
58065
TrEMBL
other Location (Reliability: 3)
A0A8I6AM78_RAT
1708
0
187277
TrEMBL
Secretory Pathway (Reliability: 1)
Q4JFL7_RAT
1495
2
167524
TrEMBL
Secretory Pathway (Reliability: 2)
A0A8I6AEM0_RAT
1897
1
212729
TrEMBL
Secretory Pathway (Reliability: 1)
Q62797_RAT
1216
2
137611
TrEMBL
Secretory Pathway (Reliability: 3)
A0A8I5ZV35_RAT
2000
1
224208
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8I5ZZK7_RAT
2273
0
250241
TrEMBL
other Location (Reliability: 2)
A0A0G2JZ01_RAT
602
0
66097
TrEMBL
other Location (Reliability: 3)
A0A8I6AMP6_RAT
120
0
13772
TrEMBL
other Location (Reliability: 3)
A0A8I6AGT7_RAT
168
0
18741
TrEMBL
other Location (Reliability: 2)
D3ZRE9_RAT
188
0
20579
TrEMBL
other Location (Reliability: 1)
F1LMY3_RAT
2316
1
255371
TrEMBL
Secretory Pathway (Reliability: 1)
F1M8J3_RAT
1711
0
187284
TrEMBL
Secretory Pathway (Reliability: 1)
B5DFF7_RAT
185
0
20468
TrEMBL
other Location (Reliability: 1)
A0A0G2K8V0_RAT
1490
1
167670
TrEMBL
Secretory Pathway (Reliability: 1)
G3V9S3_RAT
2460
0
271047
TrEMBL
other Location (Reliability: 2)
A0A0G2JYG7_RAT
549
1
62015
TrEMBL
other Location (Reliability: 3)
A0A8I5ZN71_RAT
763
0
85534
TrEMBL
other Location (Reliability: 4)
A0A0G2K1K1_RAT
2445
0
269443
TrEMBL
other Location (Reliability: 2)
A0A8I6A6L8_RAT
2266
0
249732
TrEMBL
other Location (Reliability: 2)
A0A8I5ZLG1_RAT
1170
0
130946
TrEMBL
other Location (Reliability: 1)
F1LQQ5_RAT
1018
0
114607
TrEMBL
other Location (Reliability: 3)
G3V6L5_RAT
656
1
73968
TrEMBL
Secretory Pathway (Reliability: 3)
A0A0G2JUZ7_RAT
2302
1
256684
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8I6G9U8_RAT
1623
1
181130
TrEMBL
Secretory Pathway (Reliability: 2)
A0A0G2JTB7_RAT
1175
0
133439
TrEMBL
Mitochondrion (Reliability: 2)
G3V8P4_RAT
1904
1
212128
TrEMBL
Secretory Pathway (Reliability: 2)
A0A8I6G7Q4_RAT
166
0
19021
TrEMBL
other Location (Reliability: 3)
A0A8I6AB94_RAT
335
0
37053
TrEMBL
other Location (Reliability: 2)
A0A8I6GK94_RAT
1352
1
148371
TrEMBL
other Location (Reliability: 3)
A0A8I5ZUR1_RAT
500
0
56202
TrEMBL
other Location (Reliability: 5)
A0A8I6A6D9_RAT
1413
1
157876
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8I6AU71_RAT
414
0
48501
TrEMBL
other Location (Reliability: 3)
A0A8I6ARV6_RAT
217
0
24365
TrEMBL
other Location (Reliability: 3)
A0A0G2K8C7_RAT
1206
0
134977
TrEMBL
other Location (Reliability: 3)
A0A8I5ZXS1_RAT
2238
1
250168
TrEMBL
Secretory Pathway (Reliability: 2)
G3V7Q4_RAT
766
0
85984
TrEMBL
other Location (Reliability: 4)
A0A8I6A7K8_RAT
538
0
61016
TrEMBL
Mitochondrion (Reliability: 5)
Q5FWV8_RAT
369
0
41569
TrEMBL
other Location (Reliability: 1)
A0A0G2K2W0_RAT
2240
1
250305
TrEMBL
Secretory Pathway (Reliability: 3)
A0A8I6A789_RAT
1505
1
169341
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8I5ZQW7_RAT
153
0
17612
TrEMBL
other Location (Reliability: 2)
F1LPJ1_RAT
1486
1
167247
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0G2JXZ9_RAT
1289
1
141917
TrEMBL
other Location (Reliability: 3)
A0A8I6AFL3_RAT
1455
1
163134
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8I5YBL2_RAT
932
0
105554
TrEMBL
Mitochondrion (Reliability: 3)
A0A0G2JWT3_RAT
558
0
60928
TrEMBL
other Location (Reliability: 3)
A0A8I6AMA6_RAT
410
1
47721
TrEMBL
other Location (Reliability: 1)
D3ZHX6_RAT
496
0
54433
TrEMBL
other Location (Reliability: 1)
D3ZW40_RAT
1191
0
132943
TrEMBL
other Location (Reliability: 1)
A0A8I6AR92_RAT
535
0
60091
TrEMBL
Mitochondrion (Reliability: 5)
A0A8I6A7V1_RAT
585
0
63805
TrEMBL
other Location (Reliability: 1)
M0R711_RAT
1903
2
211773
TrEMBL
Secretory Pathway (Reliability: 2)
E9PTJ3_RAT
658
0
71556
TrEMBL
other Location (Reliability: 2)
G3V9T9_RAT
613
0
69618
TrEMBL
other Location (Reliability: 4)
Q63683_RAT
367
0
39616
TrEMBL
other Location (Reliability: 3)
Q8CIN2_RAT
1397
1
156024
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8I6AUL6_RAT
719
1
82714
TrEMBL
other Location (Reliability: 5)
F1LPJ5_RAT
384
0
42130
TrEMBL
Mitochondrion (Reliability: 5)
PDB
SCOP
CATH
UNIPROT
ORGANISM
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
190000
-
receptor-type protein tyrosine phosphatase, isoform RPTPgamma-A, treatment with N-glycanase reduce the value to 175000 Da
41000
-
x * 41000, SDS-PAGE, recombinant catalytic domain of protein tyrosine phosphatase ny, His-tag free
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
-
consists of two tandemly repeated phosphatase domains in the cytoplasmic region, domain CD1 is enzymatically active and is influenced by the catalytically inactive domain CD2
?
-
x * 41000, SDS-PAGE, recombinant catalytic domain of protein tyrosine phosphatase ny, His-tag free
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
glycoprotein
-
receptor-type protein tyrosine phosphatase, isoforms RPTPgamma-A, RPTPgamma-B, RPTPgamma-C, RPTPgamma-S are glycoproteins
phosphoprotein
-
aggregation of the high-affinity IgE receptor FceRI induces the phosphorylation of PTP-PEST at Ser39, thus resulting in the suppression of enzyme activity
side-chain modification
-
alternative splicing of the brain enzyme produces 3 isoforms: PTPxi-A, the full-length form, PTPxi-B, the short form and PTPxi-S an extracellular variant, all three variants are chondroitin sulfate proteoglycans
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
hanging drop vapour diffusion method with 20% PEG 10000, 0.1 M MES pH 6.5
-
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
-
enzyme activity is significantly suppressed in the liver microsomes of regucalcin transgenic rats
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
recombinant His-tagged catalytic domain of protein tyrosine phosphatase ny
-
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
receptor-type protein tyrosine phosphatase, isoforms RPTPgamma-A, RPTPgamma-B, RPTPgamma-C, RPTPgamma-S, expression in COS7 cells
-
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
PTP-PEST mRNA expression is significantly induced upon the high-affinity IgE receptor FceRI-crosslinking
-
APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
medicine
-
PTPalpha and PTP1B responsible for counteraction of insulin signaling, LAR and PTPalpha may act upon cell surface insulin receptors
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Tamura, S.; Suzuki, Y.; Kikuchi, K.; Tsuiki, S.
Identification and characterization of Mg2+-dependent phosphotyrosyl protein phosphatase from rat liver cytosol
Biochem. Biophys. Res. Commun.
140
212-218
1986
Rattus norvegicus
Okada, M.; Owada, K.; Nakagawa, H.
[Phosphotyrosine]protein phosphatase in rat brain. A major [phosphotyrosine]protein phosphatase is a 23 kDa protein distinct from acid phosphatase
Biochem. J.
239
155-162
1986
Rattus norvegicus
Brunati, A.M.; Pinna, L.A.
Isolation and partial characterization of distinct species of phosphotyrosyl protein phosphatases from rat spleen
Biochem. Biophys. Res. Commun.
133
929-936
1985
Rattus norvegicus
Gallis, B.; Bornstein, P.; Brautigan., D.L.
Tyrosylprotein kinase and phosphatase activities in membrane vesicles from normal and Rous sarcoma virus-transformed rat cells
Proc. Natl. Acad. Sci. USA
78
6689-6693
1981
Rattus norvegicus
Foulkes, J.G.; Howard, R.F.; Ziemiecki, A.
Detection of a novel mammalian protein phosphatase with activity for phosphotyrosine
FEBS Lett.
130
197-200
1981
Rattus norvegicus
Foulkes, J.G.
Phosphotyrosyl-protein phosphatases
Curr. Top. Microbiol. Immunol.
107
163-180
1983
Gallus gallus, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus
Nishiwaki, T.; Maeda, N.; Noda, M.
Characterization and developmental regulation of proteoglycan-type protein-tyrosine phosphatase xi/RPTPbeta isoforms
J. Biochem.
123
458-467
1998
Rattus norvegicus
Shintani, T.; Maeda, N.; Nishiwaki, T.; Noda, M.
Characterization of rat receptor-like protein tyrosine phosphatase gamma isoforms
Biochem. Biophys. Res. Commun.
230
419-4235
1997
Rattus norvegicus
Zhang, Z.Y.
Kinetic and mechanistic characterization of a mammalian protein-tyrosine phosphatase, PTP1
J. Biol. Chem.
270
11199-11204
1995
Rattus norvegicus
Pot, D.A.; Woodford, T.A.; Remboutsika, E.; Haun, R.S.; Dixon, J.E.
Cloning, bacterial expression, purification, and characterization of the cytoplasmic domain of rat LAR, a receptor-like protein tyrosine phosphatase
J. Biol. Chem.
266
19688-19696
1991
Rattus norvegicus (Q64604)
Chengalvala, M.V.; Bapat, A.R.; Hurlburt, W.W.; Kostek, B.; Gonder, D.S.; Mastroeni, R.A.; Frail, D.E.
Biochemical characterization of osteo-testicular protein tyrosine phosphatase and its functional significance in rat primary osteoblasts
Biochemistry
40
814-821
2001
Rattus norvegicus
Calera, M.R.; Vallega, G.; Pilch, P.F.
Dynamics of protein-tyrosine phosphatases in rat adipocytes
J. Biol. Chem.
275
6308-6312
2000
Rattus norvegicus
Seligman, J.; Zipser, Y.; Kosower, N.S.
Tyrosine phosphorylation, thiol status, and protein tyrosine phosphatase in rat epididymal spermatozoa
Biol. Reprod.
71
1009-1015
2004
Rattus norvegicus
Fukaya, Y.; Yamaguchi, M.
Characterization of protein tyrosine phosphatase activity in rat liver microsomes: suppressive effect of endogenous regucalcin in transgenic rats
Int. J. Mol. Med.
14
427-432
2004
Rattus norvegicus
Easton, J.B.; Royer, A.R.; Middlemas, D.S.
The protein tyrosine phosphatase, Shp2, is required for the complete activation of the RAS/MAPK pathway by brain-derived neurotrophic factor
J. Neurochem.
97
834-845
2006
Rattus norvegicus
Santos, M.A.; Santos, S.M.; Matozo, H.C.; Portugal, R.V.; Iuliano, R.; Fusco, A.; Polikarpov, I.
Expression, purification, and characterization of rat protein tyrosine phosphatase eta catalytic domain
Protein Expr. Purif.
41
113-120
2005
Rattus norvegicus
Matozo, H.C.; Nascimento, A.S.; Santos, M.A.; Iuliano, R.; Fusco, A.; Polikarpov, I.
Crystallization and preliminary X-ray diffraction analysis of rat protein tyrosine phosphatase eta
Acta Crystallogr. Sect. F
62
923-925
2006
Rattus norvegicus
Noordman, Y.E.; Jansen, P.A.; Hendriks, W.J.
Tyrosine-specific MAPK phosphatases and the control of ERK signaling in PC12 cells
J. Mol. Signal.
1
2006
2006
Mus musculus, Rattus norvegicus
Braithwaite, S.P.; Xu, J.; Leung, J.; Urfer, R.; Nikolich, K.; Oksenberg, D.; Lombroso, P.J.; Shamloo, M.
Expression and function of striatal enriched protein tyrosine phosphatase is profoundly altered in cerebral ischemia
Eur. J. Neurosci.
27
2444-2452
2008
Rattus norvegicus
Navarrete-Vazquez, G.; Paoli, P.; Leon-Rivera, I.; Villalobos-Molina, R.; Medina-Franco, J.L.; Ortiz-Andrade, R.; Estrada-Soto, S.; Camici, G.; Diaz-Coutino, D.; Gallardo-Ortiz, I.; Martinez-Mayorga, K.; Moreno-Diaz, H.
Synthesis, in vitro and computational studies of protein tyrosine phosphatase 1B inhibition of a small library of 2-arylsulfonylaminobenzothiazoles with antihyperglycemic activity
Bioorg. Med. Chem.
17
3332-3341
2009
Rattus norvegicus
Fukuda, S.; Ohta, T.; Sakata, S.; Morinaga, H.; Ito, M.; Nakagawa, Y.; Tanaka, M.; Matsushita, M.
Pharmacological profiles of a novel protein tyrosine phosphatase 1B inhibitor, JTT-551
Diabetes Obes. Metab.
12
299-306
2010
Homo sapiens, Mus musculus, Rattus norvegicus
Nakashima, S.; Arnold, S.A.; Mahoney, E.T.; Sithu, S.D.; Zhang, Y.P.; D'Souza, S.E.; Shields, C.B.; Hagg, T.
Small-molecule protein tyrosine phosphatase inhibition as a neuroprotective treatment after spinal cord injury in adult rats
J. Neurosci.
28
7293-7303
2008
Rattus norvegicus
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