Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 3.1.3.48 - protein-tyrosine-phosphatase and Organism(s) Drosophila melanogaster

for references in articles please use BRENDA:EC3.1.3.48
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.3 Phosphoric-monoester hydrolases
                3.1.3.48 protein-tyrosine-phosphatase
IUBMB Comments
Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2, non-specific protein-tyrosine kinase.
Specify your search results
Select one or more organisms in this record: ?
This record set is specific for:
Drosophila melanogaster
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
hide
The taxonomic range for the selected organisms is: Drosophila melanogaster
The enzyme appears in selected viruses and cellular organisms
Synonyms
ptp1b, protein tyrosine phosphatase, shp-1, shp-2, tyrosine phosphatase, protein phosphatase 2a, acid phosphatase activity, mkp-1, cdc25a, ptpn22, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
70Z-SHP
-
-
-
-
Brain-derived phosphatase
-
-
-
-
BVP
-
-
-
-
CD148 antigen
-
-
-
-
CD45
-
-
-
-
CD45 antigen
-
-
-
-
Cdc25-like protein
-
-
-
-
CDK2-associated dual specificity phosphatase
-
-
-
-
Ch-1PTPase
-
-
-
-
CPTP1
-
-
-
-
DLAR
-
-
-
-
dPTP61F
-
dPTP61F plays a central role in counteracting PTK-mediated signaling pathways as well as in regulating actin reorganization and remodeling through tyrosine dephosphorylation of critical substrates in Drosophila
Dual specificity phosphatase Cdc25A
-
-
-
-
Dual specificity phosphatase Cdc25B
-
-
-
-
Dual specificity phosphatase Cdc25C
-
-
-
-
Dual specificity protein phosphatase hVH1
-
-
-
-
Dual specificity protein phosphatase hVH2
-
-
-
-
Dual specificity protein phosphatase hVH3
-
-
-
-
Dual specificity protein phosphatase PYST1
-
-
-
-
Dual specificity protein phosphatase PYST2
-
-
-
-
Dual specificity protein phosphatase VHR
-
-
-
-
Dual-specificity tyrosine phosphatase TS-DSP6
-
-
-
-
Dual-specificity tyrosine phosphatase YVH1
-
-
-
-
ES cell phosphatase
-
-
-
-
HCP
-
-
-
-
Hematopoietic cell protein-tyrosine phosphatase
-
-
-
-
Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP
-
-
-
-
Hematopoietic protein-tyrosine phosphatase
-
-
-
-
HEPTP
-
-
-
-
HPTP beta-like tyrosine phosphatase
-
-
-
-
HPTP eta
-
-
-
-
hPTPE1
-
-
-
-
ICAAR
-
-
-
-
Islet cell autoantigen related protein
-
-
-
-
kinase associated phosphatase
-
-
-
-
L-CA
-
-
-
-
Late protein H1
-
-
-
-
LCA
-
-
-
-
LCA-related phosphatase
-
-
-
-
Leukocyte antigen related
-
-
-
-
Low molecular weight cytosolic acid phosphatase
-
-
-
-
LRP
-
-
-
-
Lymphoid phosphatase
-
-
-
-
LyP
-
-
-
-
M1851
-
-
-
-
MAP-kinase phosphatase CPG21
-
-
-
-
MEG
-
-
-
-
Mitosis initiation protein
-
-
-
-
Mitosis initiation protein MIH1
-
-
-
-
Mitotic inducer homolog
-
-
-
-
MKP-1 like protein tyrosine phosphatase
-
-
-
-
MPTP
-
-
-
-
MPTP-PEST
-
-
-
-
NC-PTPCOM1
-
-
-
-
Neural-specific protein-tyrosine phosphatase
-
-
-
-
ORF5
-
-
-
-
OST-PTP
-
-
-
-
P19-PTP
-
-
-
-
P80
-
-
-
-
PC12-PTP1
-
-
-
-
Phogrin
-
-
-
-
Phosphacan
-
-
-
-
phosphatase, phosphoprotein (phosphotyrosine)
-
-
-
-
phosphatase, phosphotyrosine
-
-
-
-
phosphoprotein phosphatase (phosphotyrosine)
-
-
-
-
phosphotyrosine histone phosphatase
-
-
-
-
phosphotyrosine phosphatase
-
-
-
-
Phosphotyrosine phosphatase 13
-
-
-
-
phosphotyrosine protein phosphatase
-
-
-
-
phosphotyrosylprotein phosphatase
-
-
-
-
protein phosphotyrosine phosphatase
-
-
-
-
protein tyrosine phosphatase
-
-
Protein tyrosine phosphatase-NP
-
-
-
-
Protein-protein-tyrosine phosphatase HA2
-
-
-
-
Protein-tyrosine phosphatase 1B
-
-
-
-
Protein-tyrosine phosphatase 1C
-
-
-
-
Protein-tyrosine phosphatase 1E
-
-
-
-
Protein-tyrosine phosphatase 2C
-
-
-
-
Protein-tyrosine phosphatase 2E
-
-
-
-
Protein-tyrosine phosphatase 3CH134
-
-
-
-
Protein-tyrosine phosphatase CL100
-
-
-
-
Protein-tyrosine phosphatase D1
-
-
-
-
Protein-tyrosine phosphatase ERP
-
-
-
-
Protein-tyrosine phosphatase G1
-
-
-
-
Protein-tyrosine phosphatase H1
-
-
-
-
Protein-tyrosine phosphatase LC-PTP
-
-
-
-
Protein-tyrosine phosphatase MEG1
-
-
-
-
Protein-tyrosine phosphatase MEG2
-
-
-
-
Protein-tyrosine phosphatase P19
-
-
-
-
Protein-tyrosine phosphatase PCPTP1
-
-
-
-
Protein-tyrosine phosphatase pez
-
-
-
-
Protein-tyrosine phosphatase PTP-RL10
-
-
-
-
Protein-tyrosine phosphatase PTP36
-
-
-
-
Protein-tyrosine phosphatase PTPL1
-
-
-
-
Protein-tyrosine phosphatase striatum-enriched
-
-
-
-
Protein-tyrosine phosphatase SYP
-
-
-
-
Protein-tyrosine-phosphatase SL
-
-
-
-
Protein-tyrosine-phosphate phosphohydrolase
-
-
-
-
PTP IA-2beta
-
-
-
-
PTP-1B
-
-
-
-
PTP-1C
-
-
-
-
PTP-1D
-
-
-
-
PTP-2C
-
-
-
-
PTP-BAS
-
-
-
-
PTP-E1
-
-
-
-
PTP-H1
-
-
-
-
PTP-HA2
-
-
-
-
PTP-NP
-
-
-
-
PTP-SH2beta
-
-
-
-
PTP1C
-
-
-
-
PTP1D
-
-
-
-
PTP2C
-
-
-
-
PTPase YVH1
-
-
-
-
PTPase-MEG1
-
-
-
-
PTPase-MEG2
-
-
-
-
PTPG1
-
-
-
-
PTPN6
-
-
-
-
PTPNE6
-
-
-
-
PY protein phosphatase
-
-
-
-
R-PTP-alpha
-
-
-
-
R-PTP-beta
-
-
-
-
R-PTP-delta
-
-
-
-
R-PTP-epsilon
-
-
-
-
R-PTP-eta
-
-
-
-
R-PTP-gamma
-
-
-
-
R-PTP-kappa
-
-
-
-
R-PTP-mu
-
-
-
-
R-PTP-zeta
-
-
-
-
Receptor-linked protein-tyrosine phosphatase 10D
-
-
-
-
Receptor-linked protein-tyrosine phosphatase 99A
-
-
-
-
RNA/RNP complex-intereracting phosphatase
-
-
-
-
ROL B protein
-
-
-
-
RPTPalpha
-
-
-
-
SH-PTP1
-
-
-
-
SH-PTP2
-
-
-
-
SH-PTP3
-
-
-
-
SHP
-
-
-
-
Small tyrosine phosphatase
-
-
-
-
Small, acidic phosphotyrosine protein phosphatase
-
-
-
-
STEP
-
-
-
-
String protein
-
-
-
-
Syp
-
-
-
-
T-cell protein-tyrosine phosphatase
-
-
-
-
T-DSP11
-
-
-
-
T200
-
-
-
-
TCPTP
-
-
-
-
Testis-and skeletal-muscle-specific DSP
-
-
-
-
tyrosine O-phosphate phosphatase
-
-
-
-
Tyrosine phosphatase CBPTP
-
-
-
-
tyrosylprotein phosphatase
-
-
-
-
[phosphotyrosine]protein phosphatase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of phosphoric ester
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
protein-tyrosine-phosphate phosphohydrolase
Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2, non-specific protein-tyrosine kinase.
CAS REGISTRY NUMBER
COMMENTARY hide
79747-53-8
-
97162-86-2
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
phosphorylated Abelson interacting protein + H2O
Abelson interacting protein + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated Abl tyrosine kinase + H2O
Abl tyrosine kinase + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated Ack protein + H2O
Ack protein + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated Down syndrome cell adhesion molecule + H2O
Down syndrome cell adhesion molecule + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated eukaryotic-initiation-factor-4G + H2O
eukaryotic-initiation-factor-4G + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated fragile X related + H2O
fragile X related + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated HEM protein + H2O
HEM protein + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated hepatocyte growth factor regulated tyrosine kinase substrate + H2O
hepatocyte growth factor regulated tyrosine kinase substrate + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated Hsc-70-4 + H2O
Hsc-70-4 + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated IGF-II mRNA-binding protein + H2O
IGF-II mRNA-binding protein + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated Lasp protein + H2O
Lasp protein + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated PDGF- and VEGF-receptor related + H2O
PDGF- and VEGF-receptor related + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated poly(A)-binding protein + H2O
poly(A)-binding protein + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated polychaetoid + H2O
polychaetoid + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated rasputin + H2O
rasputin + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated RhoGAP15B + H2O
RhoGAP15B + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated SCAR + H2O
SCAR + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated SH3PX1 + H2O
SH3PX1 + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated specifically Rac1-associated protein 1 + H2O
specifically Rac1-associated protein 1 + phosphate
show the reaction diagram
-
-
-
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
-
no effect
Mn2+
-
no effect
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1-p-Bromotetramisole oxalate
-
tetramizole no effect
L-phenylalanine
-
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7 - 7.5
-
phosphate transfer
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
PRL1_DROME
176
0
19973
Swiss-Prot
other Location (Reliability: 3)
MPIP_DROME
479
0
54095
Swiss-Prot
other Location (Reliability: 1)
PTP10_DROME
1990
2
222740
Swiss-Prot
Mitochondrion (Reliability: 2)
PPAC1_DROME
155
0
17556
Swiss-Prot
other Location (Reliability: 5)
PPAC2_DROME
164
0
18541
Swiss-Prot
Mitochondrion (Reliability: 3)
PTPM1_DROME
200
0
23156
Swiss-Prot
other Location (Reliability: 5)
EYA_DROME
766
0
80657
Swiss-Prot
other Location (Reliability: 2)
DUSK3_DROME
411
0
45792
Swiss-Prot
other Location (Reliability: 2)
DUSK4_DROME
387
0
43742
Swiss-Prot
other Location (Reliability: 4)
TWINE_DROME
426
0
48320
Swiss-Prot
other Location (Reliability: 1)
LAR_DROME
2029
0
229056
Swiss-Prot
Secretory Pathway (Reliability: 1)
PTP61_DROME
548
1
62105
Swiss-Prot
other Location (Reliability: 2)
PTP69_DROME
1462
1
167460
Swiss-Prot
Secretory Pathway (Reliability: 1)
PTP99_DROME
1301
1
145396
Swiss-Prot
Secretory Pathway (Reliability: 1)
SSH_DROME
1045
0
114997
Swiss-Prot
other Location (Reliability: 2)
CSW_DROME
845
0
92975
Swiss-Prot
other Location (Reliability: 3)
Q9VLW7_DROME
1052
0
115423
TrEMBL
other Location (Reliability: 1)
A8DZ18_DROME
2011
0
227414
TrEMBL
other Location (Reliability: 3)
Q8IRS0_DROME
1607
2
182287
TrEMBL
other Location (Reliability: 5)
Q8SXF8_DROME
206
0
23329
TrEMBL
Mitochondrion (Reliability: 4)
Q9W2F3_DROME
1377
0
152975
TrEMBL
other Location (Reliability: 2)
E1JJE4_DROME
1615
2
183075
TrEMBL
other Location (Reliability: 5)
M9ND38_DROME
676
0
70469
TrEMBL
other Location (Reliability: 3)
X2JEB8_DROME
235
0
26832
TrEMBL
other Location (Reliability: 5)
Q24495_DROME
1767
2
200121
TrEMBL
other Location (Reliability: 5)
M9PDF7_DROME
1927
0
217713
TrEMBL
Secretory Pathway (Reliability: 1)
M9PFW0_DROME
411
0
45792
TrEMBL
other Location (Reliability: 2)
A8JV04_DROME
1241
0
137544
TrEMBL
other Location (Reliability: 2)
Q8SX38_DROME
343
0
40807
TrEMBL
other Location (Reliability: 3)
M9PBC2_DROME
426
0
48320
TrEMBL
other Location (Reliability: 1)
A8JUQ2_DROME
226
0
25702
TrEMBL
other Location (Reliability: 5)
Q9V3L4_DROME
509
0
58432
TrEMBL
other Location (Reliability: 4)
E3CTN5_DROME
1146
1
128671
TrEMBL
other Location (Reliability: 1)
M9MS42_DROME
790
0
84895
TrEMBL
other Location (Reliability: 2)
M9PD76_DROME
2032
0
229341
TrEMBL
Secretory Pathway (Reliability: 1)
Q7KMQ6_DROME
514
0
58953
TrEMBL
other Location (Reliability: 4)
M9PG93_DROME
1941
0
219393
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0B4LHX7_DROME
369
0
39487
TrEMBL
Mitochondrion (Reliability: 4)
E1JHB2_DROME
700
0
78187
TrEMBL
other Location (Reliability: 1)
Q9Y0B6_DROME
418
0
48067
TrEMBL
other Location (Reliability: 4)
Q5U0V6_DROME
693
0
77461
TrEMBL
other Location (Reliability: 1)
Q8MLR7_DROME
761
0
87047
TrEMBL
other Location (Reliability: 2)
Q7YU03_DROME
1250
0
138616
TrEMBL
other Location (Reliability: 2)
X2JCK2_DROME
1761
2
199357
TrEMBL
other Location (Reliability: 5)
A0A0B4JDF4_DROME
922
0
103853
TrEMBL
other Location (Reliability: 3)
X2J9T8_DROME
690
0
77114
TrEMBL
other Location (Reliability: 1)
M9NCY3_DROME
1912
0
216357
TrEMBL
other Location (Reliability: 3)
Q9W1Q6_DROME
689
0
78751
TrEMBL
other Location (Reliability: 2)
Q9W323_DROME
827
0
89284
TrEMBL
other Location (Reliability: 2)
Q8IRM7_DROME
797
0
85757
TrEMBL
other Location (Reliability: 1)
A1ZAS8_DROME
754
0
83892
TrEMBL
other Location (Reliability: 2)
Q8SXB2_DROME
1064
1
120525
TrEMBL
other Location (Reliability: 5)
Q8IRJ0_DROME
856
0
95557
TrEMBL
Secretory Pathway (Reliability: 2)
Q9W324_DROME
802
0
86532
TrEMBL
Mitochondrion (Reliability: 4)
Q59E68_DROME
597
0
64629
TrEMBL
other Location (Reliability: 3)
Q9NGL1_DROME
203
0
22848
TrEMBL
Mitochondrion (Reliability: 3)
Q9VAL5_DROME
1397
2
157337
TrEMBL
Secretory Pathway (Reliability: 3)
Q8WSF2_DROME
973
0
109113
TrEMBL
Mitochondrion (Reliability: 4)
Q8IRM6_DROME
498
0
53329
TrEMBL
other Location (Reliability: 1)
Q9W0R3_DROME
974
0
109667
TrEMBL
Mitochondrion (Reliability: 4)
Q9W4F5_DROME
1767
2
200075
TrEMBL
other Location (Reliability: 5)
M9PDR3_DROME
1935
0
218481
TrEMBL
Secretory Pathway (Reliability: 1)
M9PGI1_DROME
894
0
98260
TrEMBL
Secretory Pathway (Reliability: 2)
Q9VHV8_DROME
476
0
51271
TrEMBL
other Location (Reliability: 3)
A1ZAB3_DROME
1433
2
160062
TrEMBL
Secretory Pathway (Reliability: 2)
M9PG13_DROME
497
0
54805
TrEMBL
other Location (Reliability: 2)
Q9NDR1_DROME
747
0
83074
TrEMBL
other Location (Reliability: 2)
Q8IRH4_DROME
431
1
48517
TrEMBL
other Location (Reliability: 2)
A0A1B2AJ78_DROME
164
0
18541
TrEMBL
Mitochondrion (Reliability: 3)
Q9VWN2_DROME
206
0
23299
TrEMBL
Mitochondrion (Reliability: 4)
Q7KK51_DROME
639
0
72909
TrEMBL
other Location (Reliability: 3)
D2NUJ1_DROME
155
0
17556
TrEMBL
other Location (Reliability: 5)
A0A0B4KI54_DROME
479
0
54095
TrEMBL
other Location (Reliability: 1)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
61000
-
nucleus-localized enzyme form, calculated from amino acid sequence
62100
-
membrane-localized enzyme form, calculated from amino acid sequence
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
C237S
-
catalytically dead mutant
D203A
-
substrate-trapping mutant
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
Ni-NTA Sepharose column chromatography
-
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli BL21 DE3 cells
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Fukami, Y.; Lipman, F.
Purification of a specific reversible tyrosine-O-phosphate phosphatase
Proc. Natl. Acad. Sci. USA
79
4275-4279
1982
Drosophila melanogaster
Manually annotated by BRENDA team
Foulkes, J.G.
Phosphotyrosyl-protein phosphatases
Curr. Top. Microbiol. Immunol.
107
163-180
1983
Gallus gallus, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Chang, Y.C.; Lin, S.Y.; Liang, S.Y.; Pan, K.T.; Chou, C.C.; Chen, C.H.; Liao, C.L.; Khoo, K.H.; Meng, T.C.
Tyrosine phosphoproteomics and identification of substrates of protein tyrosine phosphatase dPTP61F in Drosophila S2 cells by mass spectrometry-based substrate trapping strategy
J. Proteome Res.
7
1055-1066
2008
Drosophila melanogaster
Manually annotated by BRENDA team