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Information on EC 3.1.3.48 - protein-tyrosine-phosphatase and Organism(s) Caenorhabditis elegans

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EC Tree
     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.3 Phosphoric-monoester hydrolases
                3.1.3.48 protein-tyrosine-phosphatase
IUBMB Comments
Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2, non-specific protein-tyrosine kinase.
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Caenorhabditis elegans
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The taxonomic range for the selected organisms is: Caenorhabditis elegans
The enzyme appears in selected viruses and cellular organisms
Synonyms
ptp1b, protein tyrosine phosphatase, shp-1, shp-2, tyrosine phosphatase, protein phosphatase 2a, acid phosphatase activity, mkp-1, cdc25a, ptpn22, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
70Z-SHP
-
-
-
-
Brain-derived phosphatase
-
-
-
-
BVP
-
-
-
-
CD148 antigen
-
-
-
-
CD45
-
-
-
-
CD45 antigen
-
-
-
-
Cdc25-like protein
-
-
-
-
CDK2-associated dual specificity phosphatase
-
-
-
-
Ch-1PTPase
-
-
-
-
CPTP1
-
-
-
-
DLAR
-
-
-
-
Dual specificity phosphatase Cdc25A
-
-
-
-
Dual specificity phosphatase Cdc25B
-
-
-
-
Dual specificity phosphatase Cdc25C
-
-
-
-
Dual specificity protein phosphatase hVH1
-
-
-
-
Dual specificity protein phosphatase hVH2
-
-
-
-
Dual specificity protein phosphatase hVH3
-
-
-
-
Dual specificity protein phosphatase PYST1
-
-
-
-
Dual specificity protein phosphatase PYST2
-
-
-
-
Dual specificity protein phosphatase VHR
-
-
-
-
Dual-specificity tyrosine phosphatase TS-DSP6
-
-
-
-
Dual-specificity tyrosine phosphatase YVH1
-
-
-
-
ES cell phosphatase
-
-
-
-
HCP
-
-
-
-
Hematopoietic cell protein-tyrosine phosphatase
-
-
-
-
Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP
-
-
-
-
Hematopoietic protein-tyrosine phosphatase
-
-
-
-
HEPTP
-
-
-
-
HPTP beta-like tyrosine phosphatase
-
-
-
-
HPTP eta
-
-
-
-
hPTPE1
-
-
-
-
ICAAR
-
-
-
-
Islet cell autoantigen related protein
-
-
-
-
kinase associated phosphatase
-
-
-
-
L-CA
-
-
-
-
Late protein H1
-
-
-
-
LCA
-
-
-
-
LCA-related phosphatase
-
-
-
-
Leukocyte antigen related
-
-
-
-
Low molecular weight cytosolic acid phosphatase
-
-
-
-
LRP
-
-
-
-
Lymphoid phosphatase
-
-
-
-
LyP
-
-
-
-
M1851
-
-
-
-
MAP-kinase phosphatase CPG21
-
-
-
-
MEG
-
-
-
-
Mitosis initiation protein
-
-
-
-
Mitosis initiation protein MIH1
-
-
-
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Mitotic inducer homolog
-
-
-
-
MKP-1 like protein tyrosine phosphatase
-
-
-
-
MPTP
-
-
-
-
MPTP-PEST
-
-
-
-
NC-PTPCOM1
-
-
-
-
Neural-specific protein-tyrosine phosphatase
-
-
-
-
ORF5
-
-
-
-
OST-PTP
-
-
-
-
P19-PTP
-
-
-
-
P80
-
-
-
-
PC12-PTP1
-
-
-
-
Phogrin
-
-
-
-
Phosphacan
-
-
-
-
phosphatase, phosphoprotein (phosphotyrosine)
-
-
-
-
phosphatase, phosphotyrosine
-
-
-
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phosphoprotein phosphatase (phosphotyrosine)
-
-
-
-
phosphotyrosine histone phosphatase
-
-
-
-
phosphotyrosine phosphatase
-
-
-
-
Phosphotyrosine phosphatase 13
-
-
-
-
phosphotyrosine protein phosphatase
-
-
-
-
phosphotyrosylprotein phosphatase
-
-
-
-
protein phosphotyrosine phosphatase
-
-
-
-
Protein tyrosine phosphatase-NP
-
-
-
-
Protein-protein-tyrosine phosphatase HA2
-
-
-
-
Protein-tyrosine phosphatase 1B
-
-
-
-
Protein-tyrosine phosphatase 1C
-
-
-
-
Protein-tyrosine phosphatase 1E
-
-
-
-
Protein-tyrosine phosphatase 2C
-
-
-
-
Protein-tyrosine phosphatase 2E
-
-
-
-
Protein-tyrosine phosphatase 3CH134
-
-
-
-
Protein-tyrosine phosphatase CL100
-
-
-
-
Protein-tyrosine phosphatase D1
-
-
-
-
Protein-tyrosine phosphatase ERP
-
-
-
-
Protein-tyrosine phosphatase G1
-
-
-
-
Protein-tyrosine phosphatase H1
-
-
-
-
Protein-tyrosine phosphatase LC-PTP
-
-
-
-
Protein-tyrosine phosphatase MEG1
-
-
-
-
Protein-tyrosine phosphatase MEG2
-
-
-
-
Protein-tyrosine phosphatase P19
-
-
-
-
Protein-tyrosine phosphatase PCPTP1
-
-
-
-
Protein-tyrosine phosphatase pez
-
-
-
-
Protein-tyrosine phosphatase PTP-RL10
-
-
-
-
Protein-tyrosine phosphatase PTP36
-
-
-
-
Protein-tyrosine phosphatase PTPL1
-
-
-
-
Protein-tyrosine phosphatase striatum-enriched
-
-
-
-
Protein-tyrosine phosphatase SYP
-
-
-
-
Protein-tyrosine-phosphatase SL
-
-
-
-
Protein-tyrosine-phosphate phosphohydrolase
-
-
-
-
PTP IA-2beta
-
-
-
-
PTP-1B
-
-
-
-
PTP-1C
-
-
-
-
PTP-1D
-
-
-
-
PTP-2C
-
-
-
-
PTP-BAS
-
-
-
-
PTP-E1
-
-
-
-
PTP-H1
-
-
-
-
PTP-HA2
-
-
-
-
PTP-NP
-
-
-
-
PTP-SH2beta
-
-
-
-
PTP1C
-
-
-
-
PTP1D
-
-
-
-
PTP2C
-
-
-
-
PTPase YVH1
-
-
-
-
PTPase-MEG1
-
-
-
-
PTPase-MEG2
-
-
-
-
PTPG1
-
-
-
-
PTPN6
-
-
-
-
PTPNE6
-
-
-
-
PY protein phosphatase
-
-
-
-
R-PTP-alpha
-
-
-
-
R-PTP-beta
-
-
-
-
R-PTP-delta
-
-
-
-
R-PTP-epsilon
-
-
-
-
R-PTP-eta
-
-
-
-
R-PTP-gamma
-
-
-
-
R-PTP-kappa
-
-
-
-
R-PTP-mu
-
-
-
-
R-PTP-zeta
-
-
-
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Receptor-linked protein-tyrosine phosphatase 10D
-
-
-
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Receptor-linked protein-tyrosine phosphatase 99A
-
-
-
-
RNA/RNP complex-intereracting phosphatase
-
-
-
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ROL B protein
-
-
-
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RPTPalpha
-
-
-
-
SH-PTP1
-
-
-
-
SH-PTP2
-
-
-
-
SH-PTP3
-
-
-
-
SHP
-
-
-
-
Small tyrosine phosphatase
-
-
-
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Small, acidic phosphotyrosine protein phosphatase
-
-
-
-
STEP
-
-
-
-
String protein
-
-
-
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Syp
-
-
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T-cell protein-tyrosine phosphatase
-
-
-
-
T-DSP11
-
-
-
-
T200
-
-
-
-
TCPTP
-
-
-
-
Testis-and skeletal-muscle-specific DSP
-
-
-
-
tyrosine O-phosphate phosphatase
-
-
-
-
Tyrosine phosphatase CBPTP
-
-
-
-
tyrosylprotein phosphatase
-
-
-
-
[phosphotyrosine]protein phosphatase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of phosphoric ester
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
protein-tyrosine-phosphate phosphohydrolase
Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2, non-specific protein-tyrosine kinase.
CAS REGISTRY NUMBER
COMMENTARY hide
79747-53-8
-
97162-86-2
-
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
EAK6_CAEEL
405
0
48334
Swiss-Prot
other Location (Reliability: 2)
PTEN_CAEEL
962
0
110329
Swiss-Prot
other Location (Reliability: 2)
YKCA_CAEEL
441
0
49492
Swiss-Prot
other Location (Reliability: 2)
MPIP3_CAEEL
316
0
36469
Swiss-Prot
other Location (Reliability: 1)
VHP1_CAEEL
657
0
71003
Swiss-Prot
Secretory Pathway (Reliability: 5)
DEP1_CAEEL
1367
1
152873
Swiss-Prot
Secretory Pathway (Reliability: 1)
PTP2_CAEEL
668
0
76743
Swiss-Prot
other Location (Reliability: 3)
TENSH_CAEEL
1354
0
151404
Swiss-Prot
other Location (Reliability: 2)
PTP1_CAEEL
1026
0
115094
Swiss-Prot
other Location (Reliability: 3)
EYA1_CAEEL
503
0
54522
Swiss-Prot
other Location (Reliability: 1)
MPIP1_CAEEL
604
0
67892
Swiss-Prot
other Location (Reliability: 1)
MPIP2_CAEEL
480
0
55737
Swiss-Prot
other Location (Reliability: 2)
DUSL_CAEEL
381
0
42174
Swiss-Prot
other Location (Reliability: 2)
MTMR3_CAEEL
1006
0
113614
Swiss-Prot
other Location (Reliability: 2)
PTPR_CAEEL
1409
0
159956
Swiss-Prot
Secretory Pathway (Reliability: 1)
CDC14_CAEEL
709
0
79740
Swiss-Prot
other Location (Reliability: 2)
LAR_CAEEL
2200
1
246620
Swiss-Prot
Mitochondrion (Reliability: 2)
PTP4_CAEEL
1159
1
131423
Swiss-Prot
Secretory Pathway (Reliability: 2)
PTP5_CAEEL
359
0
41111
Swiss-Prot
Mitochondrion (Reliability: 4)
YK13_CAEEL
398
0
44926
Swiss-Prot
other Location (Reliability: 2)
Q21762_CAEEL
278
0
32250
TrEMBL
other Location (Reliability: 2)
A0A2C9C380_CAEEL
661
0
71489
TrEMBL
Secretory Pathway (Reliability: 4)
A0A5S9MM89_CAEEL
1899
1
213247
TrEMBL
Secretory Pathway (Reliability: 1)
L8E6H9_CAEEL
2248
0
251789
TrEMBL
Secretory Pathway (Reliability: 5)
A0A0K3AXQ4_CAEEL
458
0
53304
TrEMBL
other Location (Reliability: 1)
V6CIQ1_CAEEL
2070
1
232040
TrEMBL
Mitochondrion (Reliability: 2)
Q9XXK8_CAEEL
272
0
30652
TrEMBL
other Location (Reliability: 4)
A0A5S9MN58_CAEEL
1875
1
210580
TrEMBL
Secretory Pathway (Reliability: 1)
A0A1I6CMB8_CAEEL
1431
0
162559
TrEMBL
Secretory Pathway (Reliability: 1)
V6CJV7_CAEEL
2094
1
234708
TrEMBL
Mitochondrion (Reliability: 2)
L8E6W1_CAEEL
2204
1
246845
TrEMBL
Mitochondrion (Reliability: 2)
G5EDC5_CAEEL
2009
1
225384
TrEMBL
Secretory Pathway (Reliability: 1)
A7WK41_CAEEL
164
0
18645
TrEMBL
other Location (Reliability: 3)
G5EE54_CAEEL
1985
1
222716
TrEMBL
Secretory Pathway (Reliability: 1)
Q8I120_CAEEL
1216
0
137834
TrEMBL
other Location (Reliability: 1)
L8E6Z3_CAEEL
1247
1
141304
TrEMBL
Secretory Pathway (Reliability: 2)
A0A0K3ASE2_CAEEL
373
0
43620
TrEMBL
Mitochondrion (Reliability: 3)
L8E7X5_CAEEL
2224
0
249121
TrEMBL
Secretory Pathway (Reliability: 5)