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Information on EC 3.1.3.48 - protein-tyrosine-phosphatase and Organism(s) Bos taurus

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EC Tree
     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.3 Phosphoric-monoester hydrolases
                3.1.3.48 protein-tyrosine-phosphatase
IUBMB Comments
Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2, non-specific protein-tyrosine kinase.
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This record set is specific for:
Bos taurus
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Word Map
The taxonomic range for the selected organisms is: Bos taurus
The enzyme appears in selected viruses and cellular organisms
Synonyms
ptp1b, protein tyrosine phosphatase, shp-1, shp-2, tyrosine phosphatase, protein phosphatase 2a, acid phosphatase activity, mkp-1, cdc25a, ptpn22, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
70Z-SHP
-
-
-
-
Brain-derived phosphatase
-
-
-
-
BVP
-
-
-
-
CD148 antigen
-
-
-
-
CD45
-
-
-
-
CD45 antigen
-
-
-
-
Cdc25-like protein
-
-
-
-
CDK2-associated dual specificity phosphatase
-
-
-
-
Ch-1PTPase
-
-
-
-
CPTP1
-
-
-
-
DLAR
-
-
-
-
Dual specificity phosphatase Cdc25A
-
-
-
-
Dual specificity phosphatase Cdc25B
-
-
-
-
Dual specificity phosphatase Cdc25C
-
-
-
-
Dual specificity protein phosphatase hVH1
-
-
-
-
Dual specificity protein phosphatase hVH2
-
-
-
-
Dual specificity protein phosphatase hVH3
-
-
-
-
Dual specificity protein phosphatase PYST1
-
-
-
-
Dual specificity protein phosphatase PYST2
-
-
-
-
Dual specificity protein phosphatase VHR
-
-
-
-
Dual-specificity tyrosine phosphatase TS-DSP6
-
-
-
-
Dual-specificity tyrosine phosphatase YVH1
-
-
-
-
ES cell phosphatase
-
-
-
-
HCP
-
-
-
-
Hematopoietic cell protein-tyrosine phosphatase
-
-
-
-
Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP
-
-
-
-
Hematopoietic protein-tyrosine phosphatase
-
-
-
-
HEPTP
-
-
-
-
HPTP beta-like tyrosine phosphatase
-
-
-
-
HPTP eta
-
-
-
-
hPTPE1
-
-
-
-
ICAAR
-
-
-
-
Islet cell autoantigen related protein
-
-
-
-
kinase associated phosphatase
-
-
-
-
L-CA
-
-
-
-
Late protein H1
-
-
-
-
LCA
-
-
-
-
LCA-related phosphatase
-
-
-
-
Leukocyte antigen related
-
-
-
-
Low molecular weight cytosolic acid phosphatase
-
-
-
-
LRP
-
-
-
-
Lymphoid phosphatase
-
-
-
-
LyP
-
-
-
-
M1851
-
-
-
-
MAP-kinase phosphatase CPG21
-
-
-
-
MEG
-
-
-
-
Mitosis initiation protein
-
-
-
-
Mitosis initiation protein MIH1
-
-
-
-
Mitotic inducer homolog
-
-
-
-
MKP-1 like protein tyrosine phosphatase
-
-
-
-
MPTP
-
-
-
-
MPTP-PEST
-
-
-
-
NC-PTPCOM1
-
-
-
-
Neural-specific protein-tyrosine phosphatase
-
-
-
-
ORF5
-
-
-
-
OST-PTP
-
-
-
-
P19-PTP
-
-
-
-
P80
-
-
-
-
PC12-PTP1
-
-
-
-
Phogrin
-
-
-
-
Phosphacan
-
-
-
-
phosphatase, phosphoprotein (phosphotyrosine)
-
-
-
-
phosphatase, phosphotyrosine
-
-
-
-
phosphoprotein phosphatase (phosphotyrosine)
-
-
-
-
phosphotyrosine histone phosphatase
-
-
-
-
phosphotyrosine phosphatase
-
-
-
-
Phosphotyrosine phosphatase 13
-
-
-
-
phosphotyrosine protein phosphatase
-
-
-
-
phosphotyrosylprotein phosphatase
-
-
-
-
protein phosphotyrosine phosphatase
-
-
-
-
Protein tyrosine phosphatase-NP
-
-
-
-
Protein-protein-tyrosine phosphatase HA2
-
-
-
-
Protein-tyrosine phosphatase 1B
-
-
-
-
Protein-tyrosine phosphatase 1C
-
-
-
-
Protein-tyrosine phosphatase 1E
-
-
-
-
Protein-tyrosine phosphatase 2C
-
-
-
-
Protein-tyrosine phosphatase 2E
-
-
-
-
Protein-tyrosine phosphatase 3CH134
-
-
-
-
Protein-tyrosine phosphatase CL100
-
-
-
-
Protein-tyrosine phosphatase D1
-
-
-
-
Protein-tyrosine phosphatase ERP
-
-
-
-
Protein-tyrosine phosphatase G1
-
-
-
-
Protein-tyrosine phosphatase H1
-
-
-
-
Protein-tyrosine phosphatase LC-PTP
-
-
-
-
Protein-tyrosine phosphatase MEG1
-
-
-
-
Protein-tyrosine phosphatase MEG2
-
-
-
-
Protein-tyrosine phosphatase P19
-
-
-
-
Protein-tyrosine phosphatase PCPTP1
-
-
-
-
Protein-tyrosine phosphatase pez
-
-
-
-
Protein-tyrosine phosphatase PTP-RL10
-
-
-
-
Protein-tyrosine phosphatase PTP36
-
-
-
-
Protein-tyrosine phosphatase PTPL1
-
-
-
-
Protein-tyrosine phosphatase striatum-enriched
-
-
-
-
Protein-tyrosine phosphatase SYP
-
-
-
-
Protein-tyrosine-phosphatase SL
-
-
-
-
Protein-tyrosine-phosphate phosphohydrolase
-
-
-
-
PTP IA-2beta
-
-
-
-
PTP-1B
-
-
-
-
PTP-1C
-
-
-
-
PTP-1D
-
-
-
-
PTP-2C
-
-
-
-
PTP-BAS
-
-
-
-
PTP-E1
-
-
-
-
PTP-H1
-
-
-
-
PTP-HA2
-
-
-
-
PTP-NP
-
-
-
-
PTP-SH2beta
-
-
-
-
PTP1C
-
-
-
-
PTP1D
-
-
-
-
PTP2C
-
-
-
-
PTPase YVH1
-
-
-
-
PTPase-MEG1
-
-
-
-
PTPase-MEG2
-
-
-
-
PTPG1
-
-
-
-
PTPN6
-
-
-
-
PTPNE6
-
-
-
-
PY protein phosphatase
-
-
-
-
R-PTP-alpha
-
-
-
-
R-PTP-beta
-
-
-
-
R-PTP-delta
-
-
-
-
R-PTP-epsilon
-
-
-
-
R-PTP-eta
-
-
-
-
R-PTP-gamma
-
-
-
-
R-PTP-kappa
-
-
-
-
R-PTP-mu
-
-
-
-
R-PTP-zeta
-
-
-
-
Receptor-linked protein-tyrosine phosphatase 10D
-
-
-
-
Receptor-linked protein-tyrosine phosphatase 99A
-
-
-
-
RNA/RNP complex-intereracting phosphatase
-
-
-
-
ROL B protein
-
-
-
-
RPTPalpha
-
-
-
-
SH-PTP1
-
-
-
-
SH-PTP2
-
-
-
-
SH-PTP3
-
-
-
-
SHP
-
-
-
-
Small tyrosine phosphatase
-
-
-
-
Small, acidic phosphotyrosine protein phosphatase
-
-
-
-
STEP
-
-
-
-
String protein
-
-
-
-
Syp
-
-
-
-
T-cell protein-tyrosine phosphatase
-
-
-
-
T-DSP11
-
-
-
-
T200
-
-
-
-
TCPTP
-
-
-
-
Testis-and skeletal-muscle-specific DSP
-
-
-
-
tyrosine O-phosphate phosphatase
-
-
-
-
Tyrosine phosphatase CBPTP
-
-
-
-
tyrosylprotein phosphatase
-
-
-
-
[phosphotyrosine]protein phosphatase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of phosphoric ester
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
protein-tyrosine-phosphate phosphohydrolase
Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2, non-specific protein-tyrosine kinase.
CAS REGISTRY NUMBER
COMMENTARY hide
79747-53-8
-
97162-86-2
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
1-naphthyl phosphate + H2O
1-naphthol + phosphate
show the reaction diagram
-
89.3% of the activity with 4-nitrophenyl phosphate, lung enzyme
-
-
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
show the reaction diagram
FMN + H2O
?
show the reaction diagram
-
lung enzyme
-
-
?
FMN + H2O
? + phosphate
show the reaction diagram
-
71.8% of the activity with 4-nitrophenyl phosphate, lung enzyme
-
-
?
phosphotyrosine + H2O
tyrosine + phosphate
show the reaction diagram
phosphotyrosyl-casein + H2O
? + phosphate
show the reaction diagram
-
-
-
-
?
poly(Glu,Tyr) + H2O
? + phosphate
show the reaction diagram
-
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
FMN + H2O
?
show the reaction diagram
-
lung enzyme
-
-
?
phosphotyrosine + H2O
tyrosine + phosphate
show the reaction diagram
-
lung enzyme
-
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Ca2+
-
-
Cu2+
-
lung enzyme
diphosphate
-
-
Fe2+
-
lung enzyme
H3VO4
-
-
L-Tartrate
-
no inhibition of lung enzyme
Mn2+
-
-
n-dodecyl trimethylammonium bromide
-
pH 7.0, inactivation at concentration 10fold higher than critical micellar concentration
n-hexadecyl trimethylammonium bromide
-
pH 7.0, inactivation at concentration 10fold higher than critical micellar concentration
n-tetradecyl trimethylammonium bromide
-
pH 7.0, inactivation at concentration 10fold higher than critical micellar concentration
Ni2+
-
-
p-chloromercuribenzoate
-
lung enzyme
phosphate
-
-
sodium decylsulfate
-
at concentration 10fold lower than critical micellar concentration, complete inactivation. Inactivation is independent of pH-value, irreversible and not affected by NaCl. Presence of phosphate protects
sodium dodecylsulfate
-
at concentration 10fold lower than critical micellar concentration, complete inactivation. Inactivation is independent of pH-value, irreversible and not affected by NaCl. Presence of phosphate protects
sodium octylsulfate
-
at concentration 10fold lower than critical micellar concentration, complete inactivation. Inactivation is independent of pH-value, irreversible and not affected by NaCl. Presence of phosphate protects
Sodium tetradecylsulfate
-
at concentration 10fold lower than critical micellar concentration, complete inactivation. Inactivation is independent of pH-value, irreversible and not affected by NaCl. Presence of phosphate protects
Zn2+
-
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
EDTA
-
activation
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.014 - 0.44
4-nitrophenyl phosphate
0.012 - 0.36
phosphotyrosine
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.0975
-
-
47
-
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5.5
-
substrate 4-nitrophenyl phosphate
6
-
phosphotyrosine
6.5 - 7
-
-
7
-
substrate phosphotyrosyl histone
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
-
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
DUS10_BOVIN
482
0
52389
Swiss-Prot
other Location (Reliability: 3)
MPIP3_BOVIN
477
0
53794
Swiss-Prot
other Location (Reliability: 3)
PPAP_BOVIN
387
0
44622
Swiss-Prot
Secretory Pathway (Reliability: 3)
DUS26_BOVIN
211
0
23767
Swiss-Prot
Mitochondrion (Reliability: 2)
DUS29_BOVIN
219
0
24984
Swiss-Prot
other Location (Reliability: 1)
AUXI_BOVIN
910
0
99512
Swiss-Prot
other Location (Reliability: 1)
PTPRF_BOVIN
1898
1
211382
Swiss-Prot
Secretory Pathway (Reliability: 1)
DUS6_BOVIN
381
0
42307
Swiss-Prot
other Location (Reliability: 2)
EYA2_BOVIN
537
0
58807
Swiss-Prot
other Location (Reliability: 3)
MPIP1_BOVIN
525
0
59142
Swiss-Prot
other Location (Reliability: 5)
PGP_BOVIN
321
0
34320
Swiss-Prot
other Location (Reliability: 2)
DUS14_BOVIN
198
0
22237
Swiss-Prot
Mitochondrion (Reliability: 5)
DUS18_BOVIN
188
0
21028
Swiss-Prot
Mitochondrion (Reliability: 3)
PPAC_BOVIN
158
0
18055
Swiss-Prot
other Location (Reliability: 4)
TP4A3_BOVIN
173
0
19511
Swiss-Prot
Mitochondrion (Reliability: 4)
F1MP45_BOVIN
706
1
81040
TrEMBL
Secretory Pathway (Reliability: 1)
A0A3Q1M4S8_BOVIN
352
0
38153
TrEMBL
other Location (Reliability: 3)
A0A3Q1MCH6_BOVIN
147
0
17026
TrEMBL
other Location (Reliability: 3)
F1MM08_BOVIN
394
0
42968
TrEMBL
other Location (Reliability: 1)
A0A3Q1LUF3_BOVIN
622
0
67506
TrEMBL
other Location (Reliability: 1)
E1B755_BOVIN
3372
1
378776
TrEMBL
Secretory Pathway (Reliability: 4)
Q2T9T8_BOVIN
198
0
22357
TrEMBL
Mitochondrion (Reliability: 5)
F1MME1_BOVIN
1445
1
162955
TrEMBL
Secretory Pathway (Reliability: 1)
A0A3Q1NCC1_BOVIN
539
0
60354
TrEMBL
other Location (Reliability: 3)
Q3SZ14_BOVIN
339
0
37610
TrEMBL
Mitochondrion (Reliability: 5)
A0A3Q1MFX5_BOVIN
1175
0
130024
TrEMBL
other Location (Reliability: 1)
E1BDH9_BOVIN
1386
0
155919
TrEMBL
Mitochondrion (Reliability: 5)
A0A3Q1N088_BOVIN
1120
0
124738
TrEMBL
other Location (Reliability: 1)
A6QPE0_BOVIN
339
0
38362
TrEMBL
other Location (Reliability: 4)
A5D980_BOVIN
593
0
67389
TrEMBL
other Location (Reliability: 5)
A0A3Q1MLA3_BOVIN
398
0
44966
TrEMBL
other Location (Reliability: 2)
A0A3Q1MU34_BOVIN
1502
1
168558
TrEMBL
Secretory Pathway (Reliability: 1)
F1MJR2_BOVIN
1740
1
195448
TrEMBL
Secretory Pathway (Reliability: 4)
A0A3Q1N8W9_BOVIN
462
0
51498
TrEMBL
other Location (Reliability: 3)
E1BEZ8_BOVIN
1190
0
134928
TrEMBL
Mitochondrion (Reliability: 2)
Q3T151_BOVIN
388
0
45151
TrEMBL
other Location (Reliability: 1)
A0A3Q1MNB6_BOVIN
444
0
48299
TrEMBL
Mitochondrion (Reliability: 4)
F1ME76_BOVIN
198
0
22341
TrEMBL
Mitochondrion (Reliability: 5)
A0A3Q1LI10_BOVIN
813
2
91996
TrEMBL
other Location (Reliability: 4)
A0A3Q1MCU3_BOVIN
574
0
64377
TrEMBL
other Location (Reliability: 2)
F1N008_BOVIN
1214
2
138055
TrEMBL
other Location (Reliability: 3)
A6QNL1_BOVIN
806
1
91856
TrEMBL
Secretory Pathway (Reliability: 1)
Q2KJE3_BOVIN
367
0
39528
TrEMBL
other Location (Reliability: 3)
A0A3Q1M0H5_BOVIN
1295
1
144742
TrEMBL
other Location (Reliability: 2)
A0A3Q1LZM0_BOVIN
1436
1
161017
TrEMBL
Secretory Pathway (Reliability: 1)
A0A3Q1ME68_BOVIN
1385
0
155875
TrEMBL
Mitochondrion (Reliability: 5)
A0A3Q1M5Q9_BOVIN
1907
1
212547
TrEMBL
Secretory Pathway (Reliability: 1)
F1MWL1_BOVIN
758
0
85176
TrEMBL
other Location (Reliability: 3)
A0A3Q1LYR4_BOVIN
1191
2
135088
TrEMBL
other Location (Reliability: 2)
A0A3Q1M345_BOVIN
577
0
63227
TrEMBL
Mitochondrion (Reliability: 5)
A0A3Q1MTQ9_BOVIN
1174
0
130723
TrEMBL
other Location (Reliability: 2)
A0A3Q1M7K4_BOVIN
128
0
14348
TrEMBL
other Location (Reliability: 2)
A0A3Q1ME23_BOVIN
591
0
64439
TrEMBL
other Location (Reliability: 1)
A0A3Q1LNQ8_BOVIN
321
0
36018
TrEMBL
other Location (Reliability: 4)
A0A3Q1M2R4_BOVIN
528
0
57808
TrEMBL
other Location (Reliability: 3)
A0A3Q1NJQ5_BOVIN
527
0
57748
TrEMBL
other Location (Reliability: 1)
F1MP34_BOVIN
314
0
34118
TrEMBL
other Location (Reliability: 3)
A0A3Q1N8V6_BOVIN
158
0
18087
TrEMBL
other Location (Reliability: 5)
A0A3Q1MH23_BOVIN
1798
1
201977
TrEMBL
Secretory Pathway (Reliability: 1)
A0A3Q1LUB1_BOVIN
1900
1
213184
TrEMBL
Secretory Pathway (Reliability: 1)
F1MI99_BOVIN
367
0
39544
TrEMBL
other Location (Reliability: 3)
A0A3Q1M1G8_BOVIN
545
0
59287
TrEMBL
other Location (Reliability: 1)
E1BFE2_BOVIN
2212
1
248345
TrEMBL
Secretory Pathway (Reliability: 3)
A0A3Q1LP12_BOVIN
1440
1
161049
TrEMBL
Secretory Pathway (Reliability: 2)
A0A3Q1LF97_BOVIN
324
0
34414
TrEMBL
other Location (Reliability: 3)
A0A3Q1MR31_BOVIN
194
0
22119
TrEMBL
other Location (Reliability: 1)
A0A3Q1LWJ9_BOVIN
869
0
99066
TrEMBL
other Location (Reliability: 2)
A5PK37_BOVIN
331
0
36834
TrEMBL
Mitochondrion (Reliability: 4)
A0A3Q1MEZ7_BOVIN
566
0
61717
TrEMBL
other Location (Reliability: 2)
E1BL76_BOVIN
533
0
60002
TrEMBL
other Location (Reliability: 2)
F1MJS9_BOVIN
1243
0
139450
TrEMBL
other Location (Reliability: 2)
G3MXS7_BOVIN
1385
1
154475
TrEMBL
Secretory Pathway (Reliability: 2)
A0A3Q1LMN3_BOVIN
542
0
60640
TrEMBL
other Location (Reliability: 2)
Q2T9T7_BOVIN
203
0
22555
TrEMBL
other Location (Reliability: 1)
A6QQH5_BOVIN
146
0
16456
TrEMBL
other Location (Reliability: 1)
A0A3Q1MQY4_BOVIN
1197
0
133029
TrEMBL
other Location (Reliability: 1)
F1MD22_BOVIN
1446
1
162332
TrEMBL
Secretory Pathway (Reliability: 1)
A0A3Q1LSB0_BOVIN
554
0
60649
TrEMBL
other Location (Reliability: 3)
A0A3Q1LRR1_BOVIN
1203
0
133082
TrEMBL
other Location (Reliability: 1)
A6QLS1_BOVIN
368
0
40561
TrEMBL
other Location (Reliability: 2)
A0A3Q1LHW5_BOVIN
1211
0
134516
TrEMBL
other Location (Reliability: 2)
A0A3Q1MK12_BOVIN
792
1
89707
TrEMBL
Secretory Pathway (Reliability: 2)
A0A3Q1MJ50_BOVIN
1812
1
202724
TrEMBL
Secretory Pathway (Reliability: 1)
A0A3Q1LZ43_BOVIN
1488
1
167593
TrEMBL
Secretory Pathway (Reliability: 1)
A0A3Q1MZF8_BOVIN
1998
1
221888
TrEMBL
other Location (Reliability: 2)
F1MQM7_BOVIN
457
0
49663
TrEMBL
Mitochondrion (Reliability: 3)
A0A3Q1M8J7_BOVIN
3386
1
380474
TrEMBL
Secretory Pathway (Reliability: 4)
A0A3Q1MVR1_BOVIN
1279
1
140619
TrEMBL
other Location (Reliability: 2)
F1MGK4_BOVIN
573
0
62584
TrEMBL
other Location (Reliability: 1)
A7YY43_BOVIN
185
0
20504
TrEMBL
other Location (Reliability: 1)
Q32PC4_BOVIN
167
0
18659
TrEMBL
other Location (Reliability: 1)
A0A3Q1LTI8_BOVIN
1493
1
167604
TrEMBL
Secretory Pathway (Reliability: 1)
A0A3Q1LV53_BOVIN
1395
0
156478
TrEMBL
Mitochondrion (Reliability: 5)
A0A3Q1MFX2_BOVIN
589
0
64347
TrEMBL
other Location (Reliability: 2)
A0A3Q1MEV5_BOVIN
152
0
16869
TrEMBL
other Location (Reliability: 2)
F1MM04_BOVIN
1166
1
128586
TrEMBL
other Location (Reliability: 2)
A0A3Q1N3J5_BOVIN
1982
1
220101
TrEMBL
other Location (Reliability: 2)
E1BPU9_BOVIN
1477
1
165989
TrEMBL
Secretory Pathway (Reliability: 1)
A0A3Q1LRQ3_BOVIN
1187
2
134707
TrEMBL
other Location (Reliability: 1)
A0A3Q1M422_BOVIN
1905
1
213427
TrEMBL
Secretory Pathway (Reliability: 1)
A0A3Q1MJQ2_BOVIN
1589
1
177782
TrEMBL
other Location (Reliability: 2)
A0A3Q1MPM2_BOVIN
398
0
46350
TrEMBL
other Location (Reliability: 1)
E1BPA0_BOVIN
801
1
90723
TrEMBL
Secretory Pathway (Reliability: 2)
A0A3Q1MQL1_BOVIN
1485
1
166921
TrEMBL
Secretory Pathway (Reliability: 1)
E1BJR7_BOVIN
926
0
105733
TrEMBL
Mitochondrion (Reliability: 2)
A0A3Q1MEV4_BOVIN
737
0
82856
TrEMBL
other Location (Reliability: 3)
E1BIU8_BOVIN
1922
1
213829
TrEMBL
Secretory Pathway (Reliability: 1)
Q5E9G5_BOVIN
410
0
46454
TrEMBL
other Location (Reliability: 2)
A0A3Q1LHJ6_BOVIN
1198
1
136104
TrEMBL
other Location (Reliability: 3)
A6QQD4_BOVIN
539
0
60390
TrEMBL
other Location (Reliability: 3)
Q58D75_BOVIN
312
0
35285
TrEMBL
other Location (Reliability: 3)
A0A452DIT8_BOVIN
1796
1
200291
TrEMBL
Secretory Pathway (Reliability: 1)
A0A3Q1M5K4_BOVIN
639
0
69399
TrEMBL
other Location (Reliability: 1)
A0A3Q1LU97_BOVIN
583
0
66266
TrEMBL
Mitochondrion (Reliability: 5)
F1MW70_BOVIN
345
0
38266
TrEMBL
other Location (Reliability: 2)
A0A3Q1MA02_BOVIN
1154
0
127678
TrEMBL
other Location (Reliability: 1)
A5PKF8_BOVIN
655
1
73669
TrEMBL
Secretory Pathway (Reliability: 3)
G5E541_BOVIN
339
0
38293
TrEMBL
other Location (Reliability: 4)
A5PK96_BOVIN
158
0
18169
TrEMBL
other Location (Reliability: 4)
F1N376_BOVIN
613
0
68979
TrEMBL
Mitochondrion (Reliability: 5)
A0A3Q1MQX4_BOVIN
3183
1
357761
TrEMBL
Secretory Pathway (Reliability: 4)
A0A3Q1NN38_BOVIN
521
0
58941
TrEMBL
other Location (Reliability: 2)
Q3SZ94_BOVIN
158
0
18125
TrEMBL
other Location (Reliability: 4)
F1N339_BOVIN
593
0
68010
TrEMBL
other Location (Reliability: 4)
A0A3Q1M9X9_BOVIN
1147
0
130136
TrEMBL
Mitochondrion (Reliability: 2)
F1MFJ3_BOVIN
1324
1
147975
TrEMBL
other Location (Reliability: 2)
A0A3Q1N339_BOVIN
2316
1
254138
TrEMBL
Secretory Pathway (Reliability: 1)
E1BIH4_BOVIN
944
0
107379
TrEMBL
Mitochondrion (Reliability: 4)
A6QQN2_BOVIN
425
1
49038
TrEMBL
other Location (Reliability: 1)
A5D982_BOVIN
388
0
45103
TrEMBL
other Location (Reliability: 1)
A0A452DIF1_BOVIN
512
0
57717
TrEMBL
other Location (Reliability: 5)
A0A3Q1LMJ6_BOVIN
934
0
106242
TrEMBL
other Location (Reliability: 2)
Q1KZG2_BOVIN
1399
2
156731
TrEMBL
Secretory Pathway (Reliability: 1)
F1MGK5_BOVIN
2323
1
255048
TrEMBL
Secretory Pathway (Reliability: 1)
A0A3Q1LNY4_BOVIN
1882
1
209432
TrEMBL
Secretory Pathway (Reliability: 1)
F1MKX9_BOVIN
618
0
67343
TrEMBL
other Location (Reliability: 2)
A0A3Q1M739_BOVIN
597
0
67821
TrEMBL
other Location (Reliability: 2)
E1BD15_BOVIN
645
0
70020
TrEMBL
other Location (Reliability: 1)
Q28006_BOVIN
2484
0
276385
TrEMBL
other Location (Reliability: 2)
A0A3Q1MJB0_BOVIN
1405
0
157759
TrEMBL
Mitochondrion (Reliability: 5)
F1MRH9_BOVIN
1131
0
126747
TrEMBL
Mitochondrion (Reliability: 2)
F1MEZ2_BOVIN
380
0
41589
TrEMBL
Mitochondrion (Reliability: 3)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
17800
-
x * 17800, SDS-PAGE
50000
-
gel filtration
52000
-
1 * 52000, SDS-PAGE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
-
x * 17800, SDS-PAGE
monomer
-
1 * 52000, SDS-PAGE
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
60
-
20% loss of activity after 30 min
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
very susceptible to proteolytic degradation
-
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
4°C, stable for at least 4 months
-
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
separation of seven cytosolic enzymes
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Lim Tung, H.Y.; Reed, L.J.
Identification and purification of a cytosolic phosphotyrosyl protein phosphatase from bovine spleen
Anal. Biochem.
161
412-419
1987
Bos taurus
Manually annotated by BRENDA team
Lau, K.H.W.; Farley, J.R.; Baylink, D.J.
Phosphotyrosyl-specific protein phosphatase activity of a bovine skeletal acid phosphatase isoenzyme. Comparison with the phosphotyrosyl protein phosphatase activity of skeletal alkaline phosphatase
J. Biol. Chem.
260
4653-4660
1985
Bos taurus
Manually annotated by BRENDA team
Chernoff, J.; Li, H.C.
Multiple forms of phosphotyrosyl- and phosphoseryl-protein phosphatase from cardiac muscle: partial purification and characterization of an EDTA-stimulated phosphotyrosyl-protein phosphatase
Arch. Biochem. Biophys.
226
517-530
1983
Bos taurus
Manually annotated by BRENDA team
Buzalaf, M.A.R.; Taga, E.M.; Granjeiro, J.M.; Ferreira, C.V.; Lourencao, V.A.; Ortega, M.M.; Poletto, D.W.; Aoyama, H.
Kinetic characterization of bovine lung low-molecular-weight protein tyrosine phosphatase
Exp. Lung Res.
24
269-272
1998
Bos taurus
Manually annotated by BRENDA team
Ingebritsen, T.S.
Resolution and characterization of multiple protein-tyrosine phosphatase activities
Methods Enzymol.
201
201451-465
1991
Bos taurus
-
Manually annotated by BRENDA team
Singh, T.J.
Characterization of a bovine brain magnesium-dependent phosphotyrosine protein phosphatase that is inhibited by micromolar concentrations of calcium
Biochem. Biophys. Res. Commun.
167
621-627
1990
Bos taurus
Manually annotated by BRENDA team
Granjeiro, J.M.; Miranda, M.A.; da Gloria, S.T.M.M.; Ferreira, C.V.; Taga, E.M.; Aoyama, H.; Volpe, P.L.
Effect of homologous series of n-alkyl sulfates and n-alkyl trimethylammonium bromides on low molecular mass protein tyrosine phosphatase activity
Mol. Cell. Biochem.
265
133-140
2004
Bos taurus
Manually annotated by BRENDA team