Information on EC 3.1.3.48 - protein-tyrosine-phosphatase and Organism(s) Drosophila melanogaster

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This record set is specific for:
Drosophila melanogaster


The taxonomic range for the selected organisms is: Drosophila melanogaster

The enzyme appears in selected viruses and cellular organisms

EC NUMBER
COMMENTARY hide
3.1.3.48
-
RECOMMENDED NAME
GeneOntology No.
protein-tyrosine-phosphatase
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of phosphoric ester
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
protein-tyrosine-phosphate phosphohydrolase
Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2, non-specific protein-tyrosine kinase.
CAS REGISTRY NUMBER
COMMENTARY hide
79747-53-8
-
97162-86-2
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
phosphorylated Abelson interacting protein + H2O
Abelson interacting protein + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated Abl tyrosine kinase + H2O
Abl tyrosine kinase + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated Ack protein + H2O
Ack protein + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated Down syndrome cell adhesion molecule + H2O
Down syndrome cell adhesion molecule + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated eukaryotic-initiation-factor-4G + H2O
eukaryotic-initiation-factor-4G + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated fragile X related + H2O
fragile X related + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated HEM protein + H2O
HEM protein + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated hepatocyte growth factor regulated tyrosine kinase substrate + H2O
hepatocyte growth factor regulated tyrosine kinase substrate + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated Hsc-70-4 + H2O
Hsc-70-4 + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated IGF-II mRNA-binding protein + H2O
IGF-II mRNA-binding protein + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated Lasp protein + H2O
Lasp protein + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated PDGF- and VEGF-receptor related + H2O
PDGF- and VEGF-receptor related + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated poly(A)-binding protein + H2O
poly(A)-binding protein + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated polychaetoid + H2O
polychaetoid + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated rasputin + H2O
rasputin + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated RhoGAP15B + H2O
RhoGAP15B + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated SCAR + H2O
SCAR + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated SH3PX1 + H2O
SH3PX1 + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated specifically Rac1-associated protein 1 + H2O
specifically Rac1-associated protein 1 + phosphate
show the reaction diagram
-
-
-
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
-
no effect
Mn2+
-
no effect
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1-p-Bromotetramisole oxalate
-
tetramizole no effect
L-phenylalanine
-
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7 - 7.5
-
phosphate transfer
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
61000
-
nucleus-localized enzyme form, calculated from amino acid sequence
62100
-
membrane-localized enzyme form, calculated from amino acid sequence
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Ni-NTA Sepharose column chromatography
-
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli BL21 DE3 cells
-
ENGINEERING
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
C237S
-
catalytically dead mutant
D203A
-
substrate-trapping mutant