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Information on EC 3.1.3.36 - phosphoinositide 5-phosphatase and Organism(s) Drosophila melanogaster

for references in articles please use BRENDA:EC3.1.3.36
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EC Tree
     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.3 Phosphoric-monoester hydrolases
                3.1.3.36 phosphoinositide 5-phosphatase
IUBMB Comments
These enzymes can also remove the 5-phosphate from Ins(1,4,5)P3 and/or Ins(1,3,4,5)P4. They are a diverse family of enzymes, with differing abilities to catalyse two or more of the four reactions listed. They are thought to use inositol lipids rather than inositol phosphates as substrates in vivo. All of them can use either or both of PtdIns(4,5)P2 and PtdIns(3,4,5)P3 as substrates; this is the main property that distinguishes them from EC 3.1.3.56, inositol-polyphosphate 5-phosphatase.
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Drosophila melanogaster
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The taxonomic range for the selected organisms is: Drosophila melanogaster
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
ship2, ship1, ocrl1, synaptojanin, inpp5e, synj1, phosphoinositide phosphatase, inositol polyphosphate 5-phosphatase, inositol 5-phosphatase, ci-vsp, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5PTase
-
-
-
-
diphosphoinositide phosphatase
-
-
-
-
dOCRL
-
orthologue of the human oculocerebrorenal syndrome of Lowe 1, i.e. OCRL1
inositol 5-phosphatase
-
-
inositol triphosphate 5-phosphomonoesterase
-
-
-
-
Lowe's oculocerebrorenal syndrome protein
-
-
-
-
OCRL protein
-
-
-
-
p150
-
-
-
-
phosphatase, triphosphoinositide
-
-
-
-
phosphatidyl 4,5-bisphosphate-specific phosphomonoesterase
-
-
-
-
phosphatidyl bisphosphate phosphatase
-
-
-
-
phosphatidyl-inositol 4,5-bisphosphate 5-phosphatase
-
-
-
-
phosphatidyl-myo-inositol-4,5-bisphosphate phosphatase
-
-
-
-
phosphatidyl-myo-inositol-4,5-bisphosphate phosphohydrolase
-
-
-
-
phosphatidylinositol 4,5-bisphosphate phosphatase
-
-
-
-
phosphatidylinositol-bisphosphatase
-
-
-
-
Phosphoinositide 5-phosphatase
-
-
-
-
PIP2 phosphatase
PtdIns(4,5)P2 5-phosphatase
-
-
-
-
Synaptojanin
-
-
-
-
triphosphoinositide phosphatase
-
-
-
-
triphosphoinositide phosphomonoesterase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of phosphoric ester
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-
SYSTEMATIC NAME
IUBMB Comments
phosphatidyl-myo-inositol-4,5-bisphosphate 4-phosphohydrolase
These enzymes can also remove the 5-phosphate from Ins(1,4,5)P3 and/or Ins(1,3,4,5)P4. They are a diverse family of enzymes, with differing abilities to catalyse two or more of the four reactions listed. They are thought to use inositol lipids rather than inositol phosphates as substrates in vivo. All of them can use either or both of PtdIns(4,5)P2 and PtdIns(3,4,5)P3 as substrates; this is the main property that distinguishes them from EC 3.1.3.56, inositol-polyphosphate 5-phosphatase.
CAS REGISTRY NUMBER
COMMENTARY hide
9036-01-5
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate
show the reaction diagram
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate
show the reaction diagram
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
-
dOCRL is associated with endosomes
Manually annotated by BRENDA team
-
dOCRL dephosphorylates PI(4,5)P2 on internal membranes
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
physiological function
-
dOCRL is essential for cytokinesis and cell division, it dephosphorylates phosphatidylinositol-4,5-bisphosphate on internal membranes to restrict this phosphoinositide at the plasma membrane and thereby regulates cleavage furrow formation and ingression. dOCRL is required for proper furrowing of the contractile ring and proper assembly
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
INP5E_DROME
747
0
82590
Swiss-Prot
other Location (Reliability: 4)
O46094_DROME
850
0
97530
TrEMBL
other Location (Reliability: 2)
Q5U0V7_DROME
1218
0
134599
TrEMBL
other Location (Reliability: 3)
A0A0B4K7D8_DROME
348
0
39669
TrEMBL
Secretory Pathway (Reliability: 1)
Q8MR94_DROME
959
0
105687
TrEMBL
other Location (Reliability: 4)
M9PHS8_DROME
519
0
60183
TrEMBL
other Location (Reliability: 1)
Q7K161_DROME
357
0
40498
TrEMBL
Secretory Pathway (Reliability: 1)
Q9VXE7_DROME
508
0
58973
TrEMBL
other Location (Reliability: 1)
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ben El Kadhi, K.; Roubinet, C.; Solinet, S.; Emery, G.; Carreno, S.
The inositol 5-phosphatase dOCRL controls PI(4,5)P2 homeostasis and is necessary for cytokinesis
Curr. Biol.
21
1074-1079
2011
Drosophila melanogaster
Manually annotated by BRENDA team
Fabian, L.; Wei, H.; Rollins, J.; Noguchi, T.; Blankenship, J.; Bellamkonda, K.; Polevoy, G.; Gervais, L.; Guichet, A.; Fuller, M.; Brill, J.
Phosphatidylinositol 4,5-bisphosphate directs spermatid cell polarity and exocyst localization in Drosophila
Mol. Biol. Cell
21
1546-1555
2010
Drosophila melanogaster
Manually annotated by BRENDA team