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Information on EC 3.1.3.16 - protein-serine/threonine phosphatase and Organism(s) Caenorhabditis elegans
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3.1.3.16 protein-serine/threonine phosphataseIUBMB Comments
A group of enzymes removing the serine- or threonine-bound phosphate group from a wide range of phosphoproteins, including a number of enzymes that have been phosphorylated under the action of a kinase (cf. EC 3.1.3.48 protein-tyrosine-phosphatase). The spleen enzyme also acts on phenolic phosphates and phosphamides (cf. EC 3.9.1.1, phosphoamidase).
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Word Map
- 3.1.3.16
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cyclosporine
- phosphatases
- tacrolimus
-
rejection
-
okadaic
- mycophenolate
-
allograft
- cardiac
- steroid
-
corticosteroid
- mofetil
- rapamycin
-
nephrotoxicity
- nfat
- sirolimus
- agonist
- t-cells
- creatinine
- hypertrophy
- mapks
- glycogen
- synaptic
- mtor
-
glomerular
- pkc
- platelet
-
ca2+-dependent
- hypertension
- episode
- erk
-
atopic
- cardiomyocytes
- nephropathy
-
everolimus
- dermatitis
- myocytes
-
trough
-
hyperphosphorylation
- azathioprine
-
posttransplant
-
prophylaxis
-
allogeneic
- proteinuria
- camkii
-
post-transplantation
- graft-versus-host
- rituximab
- cyclophilins
-
biopsy-proven
- prednisone
- diagnostics
- analysis
- drug development
- medicine
The taxonomic range for the selected organisms is: Caenorhabditis elegans
The enzyme appears in selected viruses and cellular organisms
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
Synonyms
calcineurin, protein phosphatase, pac-1, dusp1, dusp6, serine/threonine phosphatase, pp2ac, ppm1d, phosphoprotein phosphatase, laforin, 
more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
3-hydroxy 3-methylglutaryl CoenzymeA reductase phosphatase
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-
-
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Aspergillus awamori acid protein phosphatase
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-
-
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BCKDH phosphatase
-
-
-
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branched-chain alpha-keto acid dehydrogenase phosphatase
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-
-
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calcineurin
Calcineurin A1
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-
-
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Calcineurin A2
-
-
-
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CaM-kinase phosphatase
-
-
-
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CaMKPase
-
-
-
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casein phosphatase
-
-
-
-
DRES10
-
-
-
-
Fibroblast growth factor inducible protein 13
-
-
-
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FIN13
-
-
-
-
Flap wing protein
-
-
-
-
HMG-CoA reductase phosphatase
-
-
-
-
Magnesium-dependent calcium inhibitable phosphatase
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-
-
-
MCPP
-
-
-
-
Microtubule star protein
-
-
-
-
phosphatase 2A
-
-
-
-
phosphatase 2B
-
-
-
-
phosphatase C-II
-
-
-
-
Phosphatase esp1
-
-
-
-
phosphatase H-II
-
-
-
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phosphatase I
-
-
-
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phosphatase IB
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-
-
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phosphatase II
-
-
-
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phosphatase III
-
-
-
-
phosphatase IV
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-
-
-
phosphatase SP
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-
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phosphoglycerate mutase 5
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PGAM5 lacks PGAM activity and instead associates with signal-regulating kinase 1 and acts as a specific protein Ser/Thr phosphatase that activates apoptosis signal-regulating kinase 1, PGAM5 is a protein Ser/Thr phosphatase unrelated to the other known families of Ser/Thr phosphatases
phosphoprotein phosphatase
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-
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phosphopyruvate dehydrogenase phosphatase
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-
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phosphospectrin phosphatase
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-
-
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PK-Pase
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-
-
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polycation modulated (PCM-) phosphatase
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-
-
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PP-1A
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-
-
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PP-1B
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-
-
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PP-1G
-
-
-
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PP2A-alpha
-
-
-
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PP2A-beta
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-
-
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PP2C
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-
-
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PP2C-alpha
-
-
-
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PP2C-beta
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-
-
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PP2C-delta
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-
-
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PP2C-gamma
-
-
-
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Pp4
PP5
-
-
-
-
PP6
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-
-
-
PPEF
-
-
-
-
PPN
-
-
-
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PPT
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-
-
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protein D phosphatase
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-
-
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protein phosphatase
-
-
-
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Protein phosphatase 1A
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-
-
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Protein phosphatase 1B
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-
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Protein phosphatase 1C
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-
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Protein phosphatase magnesium-dependent 1 delta
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-
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Protein phosphatase magnesium-dependent 1 gamma
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-
-
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Protein phosphatase with EF calcium-binding domain
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-
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PSPase
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-
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Retinal degeneration C protein
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-
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small CTD phosphatase-like-1
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the protein contains a C-terminal domain phosphatase type domain
Suppressor protein SDS21
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-
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calcineurin
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-
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Pp4
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of phosphoric ester
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-
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SYSTEMATIC NAME
IUBMB Comments
protein-serine/threonine-phosphate phosphohydrolase
A group of enzymes removing the serine- or threonine-bound phosphate group from a wide range of phosphoproteins, including a number of enzymes that have been phosphorylated under the action of a kinase (cf. EC 3.1.3.48 protein-tyrosine-phosphatase). The spleen enzyme also acts on phenolic phosphates and phosphamides (cf. EC 3.9.1.1, phosphoamidase).
CAS REGISTRY NUMBER
COMMENTARY
9025-75-6
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
phosphorylated apoptosis signal-regulating kinase 1 + H2O
apoptosis signal-regulating kinase 1 + phosphate
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PGAM5 acts as a specific protein Ser/Thr phosphatase that activates apoptosis signal-regulating kinase 1 by dephosphorylation of inhibitory sites (phosphorylation of Thr-838), PGAM5 serves as a specialized activator of apoptosis signal-regulating kinase 1
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-
?
UNC-89 + H2O
?
-
the protein kinase 2 region of UNC-89 specifically interacts with SCPL-1
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-
?
additional information
?
-
-
the holoenzyme plays a role in organelle assembly and is essential for maturation of the centrosome, overview, PP4 depletion results in disrupted centrosome maturation and a decreased number of chiasmata between homologous chromosomes during meiosis in oocytes
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-
?
additional information
?
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GST-tagged PGAM5 does not dephosphorylate phospho-Tyr peptides (like END-pYINASL or DADEpYLIPQQG)
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-
?
additional information
?
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HLH-11, a member of basic helix-loop-helix proteins, binds to calcineurin catalytic subunit Tax-6, probably regulating TAX-6 as a transcription factor and/or a functional regulator. HLH-11 is involved in regulation of many developmental processes such as cell proliferation and differentiation, sex determination and myogenesis, HLH-11 deletion phenotype, overview
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-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
-
-
the holoenzyme plays a role in organelle assembly and is essential for maturation of the centrosome, overview, PP4 depletion results in disrupted centrosome maturation and a decreased number of chiasmata between homologous chromosomes during meiosis in oocytes
-
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Ca2+
Ca2+
-
between one and two Ca2+ ions/protein, bound in the EF-hands of the protein
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
-
SCPL-1 is not inhibited by the typical phosphatase inhibitors NaF, BeCl2, AlCl3, and Na3VO4
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Calmodulin
-
calcineurin is a Ca2+/calmodulin-activated Ser/Thr phosphatase
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
-
membrane-associated, N-terminus is neccessary for membrane association
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
physiological function
physiological function
-
PGAM5 is an evolutionarily conserved activator of apoptosis signal-regulating kinase 1
physiological function
-
calcineurin play roles in various signaling pathways such as fertility, movement, body size regulation and serotonin-mediated egg laying
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). FEM2_CAEEL
449
0
50898
Swiss-Prot
other Location (Reliability: 1)
PTEN_CAEEL
962
0
110329
Swiss-Prot
other Location (Reliability: 2)
PP2A_CAEEL
318
0
36302
Swiss-Prot
other Location (Reliability: 1)
SSU72_CAEEL
197
0
22775
Swiss-Prot
other Location (Reliability: 5)
YT91_CAEEL
364
0
41208
Swiss-Prot
other Location (Reliability: 1)
GLC7A_CAEEL
329
0
37205
Swiss-Prot
other Location (Reliability: 2)
GLC7B_CAEEL
333
0
37792
Swiss-Prot
other Location (Reliability: 2)
GLC7C_CAEEL
305
0
34596
Swiss-Prot
other Location (Reliability: 3)
GLC7D_CAEEL
305
0
34584
Swiss-Prot
other Location (Reliability: 3)
PHLPP_CAEEL
1126
0
128125
Swiss-Prot
other Location (Reliability: 3)
PPM1A_CAEEL
468
0
51899
Swiss-Prot
other Location (Reliability: 3)
PPP5_CAEEL
496
0
56462
Swiss-Prot
other Location (Reliability: 2)
PP2B_CAEEL
542
0
61505
Swiss-Prot
other Location (Reliability: 2)
PP2C2_CAEEL
356
0
39064
Swiss-Prot
other Location (Reliability: 1)
PP4C1_CAEEL
333
0
37359
Swiss-Prot
other Location (Reliability: 2)
PP4C2_CAEEL
321
0
36306
Swiss-Prot
other Location (Reliability: 1)
PPM1G_CAEEL
491
0
53142
Swiss-Prot
other Location (Reliability: 1)
DUSL_CAEEL
381
0
42174
Swiss-Prot
other Location (Reliability: 2)
PPE_CAEEL
707
0
80330
Swiss-Prot
other Location (Reliability: 5)
FCP1_CAEEL
659
0
74412
Swiss-Prot
other Location (Reliability: 1)
YSD1_CAEEL
454
0
51755
Swiss-Prot
other Location (Reliability: 1)
PGAM5_CAEEL
284
0
32490
Swiss-Prot
Secretory Pathway (Reliability: 3)
YY06_CAEEL
454
0
51597
Swiss-Prot
other Location (Reliability: 2)
CNEP1_CAEEL
246
1
28414
Swiss-Prot
Secretory Pathway (Reliability: 3)
PPP6_CAEEL
331
0
37388
Swiss-Prot
other Location (Reliability: 1)
RPAP2_CAEEL
455
0
52438
Swiss-Prot
other Location (Reliability: 1)
SCPL1_CAEEL
491
0
54372
Swiss-Prot
other Location (Reliability: 2)
Q27501_CAEEL
329
0
37221
TrEMBL
other Location (Reliability: 2)
Q4R171_CAEEL
300
0
33964
TrEMBL
other Location (Reliability: 2)
O45001_CAEEL
364
0
41570
TrEMBL
other Location (Reliability: 1)
O16334_CAEEL
333
0
38032
TrEMBL
Secretory Pathway (Reliability: 3)
Q27500_CAEEL
384
0
43316
TrEMBL
other Location (Reliability: 2)
Q9XW33_CAEEL
375
0
43031
TrEMBL
other Location (Reliability: 2)
P91273_CAEEL
383
0
43552
TrEMBL
other Location (Reliability: 2)
G5EC18_CAEEL
349
0
39746
TrEMBL
other Location (Reliability: 4)
Q9U3L7_CAEEL
316
0
35803
TrEMBL
other Location (Reliability: 3)
O18183_CAEEL
330
0
35292
TrEMBL
Mitochondrion (Reliability: 3)
O44507_CAEEL
383
0
42677
TrEMBL
other Location (Reliability: 2)
K8FE09_CAEEL
319
0
35554
TrEMBL
other Location (Reliability: 2)
Q21840_CAEEL
362
0
41318
TrEMBL
other Location (Reliability: 2)
Q9XVD6_CAEEL
384
0
43267
TrEMBL
other Location (Reliability: 2)
A0A0K3AU53_CAEEL
459
0
52056
TrEMBL
other Location (Reliability: 4)
W6RTP7_CAEEL
253
0
28390
TrEMBL
other Location (Reliability: 3)
Q27528_CAEEL
343
0
39142
TrEMBL
other Location (Reliability: 3)
P91569_CAEEL
296
0
34310
TrEMBL
Mitochondrion (Reliability: 1)
W6SBL5_CAEEL
204
0
22584
TrEMBL
Mitochondrion (Reliability: 5)
Q95020_CAEEL
105
0
12158
TrEMBL
other Location (Reliability: 4)
O62272_CAEEL
364
0
41162
TrEMBL
other Location (Reliability: 1)
Q4W5Q9_CAEEL
333
0
37546
TrEMBL
other Location (Reliability: 2)
Q7JK71_CAEEL
169
0
19397
TrEMBL
other Location (Reliability: 1)
Q27475_CAEEL
329
0
37336
TrEMBL
other Location (Reliability: 2)
G4SR74_CAEEL
306
0
34969
TrEMBL
other Location (Reliability: 3)
Q27494_CAEEL
368
0
42652
TrEMBL
other Location (Reliability: 1)
Q27495_CAEEL
329
0
37928
TrEMBL
other Location (Reliability: 2)
Q9U395_CAEEL
371
0
42243
TrEMBL
other Location (Reliability: 1)
Q9U3P4_CAEEL
384
0
43257
TrEMBL
other Location (Reliability: 3)
G5ECL6_CAEEL
327
0
36879
TrEMBL
other Location (Reliability: 2)
Q27496_CAEEL
363
0
41896
TrEMBL
other Location (Reliability: 1)
PDB
SCOP
CATH
UNIPROT
ORGANISM
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
-
several catalytic subunit and regulatory subunit forms, properties and interactions, overview
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
-
PP4 knockdown by PPP4c catalytic subunit-RNAi interference leads to a semi-lethal phenotype with abberations in formation of spindles in mitosis and also in sperm meiosis
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
co-expression of cacineurin with HLH-11 and interaction analysis using the yeast two-hybrid system
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ramulu, P.; Nathans, J.
Cellular and subcellular localization, N-terminal acylation, and calcium binding of Caenorhabditis elegans protein phosphatase with EF-hands
J. Biol. Chem.
276
25127-25135
2001
Caenorhabditis elegans
Cohen, P.T.; Philp, A.; Vazquez-Martin, C.
Protein phosphatase 4 - from obscurity to vital functions
FEBS Lett.
579
3278-3286
2005
Arabidopsis thaliana, Saccharomyces cerevisiae, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens
Qadota, H.; McGaha, L.A.; Mercer, K.B.; Stark, T.J.; Ferrara, T.M.; Benian, G.M.
A novel protein phosphatase is a binding partner for the protein kinase domains of UNC-89 (obscurin) in Caenorhabditis elegans
Mol. Biol. Cell
19
2424-2432
2008
Caenorhabditis elegans
Takeda, K.; Komuro, Y.; Hayakawa, T.; Oguchi, H.; Ishida, Y.; Murakami, S.; Noguchi, T.; Kinoshita, H.; Sekine, Y.; Iemura, S.; Natsume, T.; Ichijo, H.
Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1
Proc. Natl. Acad. Sci. USA
106
12301-12305
2009
Caenorhabditis elegans, Drosophila melanogaster
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