Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
endonucleolytic cleavage near pyrimidine dimers to products with 5'-phosphate
endonucleolytic cleavage near pyrimidine dimers to products with 5'-phosphate
-
-
-
-
endonucleolytic cleavage near pyrimidine dimers to products with 5'-phosphate
specific for cis-syn cyclobutane pyrimidine dimers
-
endonucleolytic cleavage near pyrimidine dimers to products with 5'-phosphate
specific for cis-syn cyclobutane pyrimidine dimers
Tequatrovirus T4
-
endonucleolytic cleavage near pyrimidine dimers to products with 5'-phosphate
cleavage on the 5'-side of dimers
-
endonucleolytic cleavage near pyrimidine dimers to products with 5'-phosphate
cleavage on the 5'-side of dimers
-
endonucleolytic cleavage near pyrimidine dimers to products with 5'-phosphate
cleavage on the 5'-side of dimers
Tequatrovirus T4
-
endonucleolytic cleavage near pyrimidine dimers to products with 5'-phosphate
salt concentrations of more than 40 mM cause the endonuclease V to shift into a distributive search mechanism instead of the processive mechanism
Tequatrovirus T4
-
endonucleolytic cleavage near pyrimidine dimers to products with 5'-phosphate
cleavage on the 3'-side of the apyrimidinic site
Tequatrovirus T4
-
endonucleolytic cleavage near pyrimidine dimers to products with 5'-phosphate
minimum chain length: longer than 10 nucleotides
-
endonucleolytic cleavage near pyrimidine dimers to products with 5'-phosphate
minimum chain length: longer than 10 nucleotides
Tequatrovirus T4
-
endonucleolytic cleavage near pyrimidine dimers to products with 5'-phosphate
Py-Py correndonuclease I creates a terminus which is more single-stranded in character than that produced by Py-Py correndonuclease II
-
endonucleolytic cleavage near pyrimidine dimers to products with 5'-phosphate
dsDNA is an effective substrate vor Py-Py correndonucleases I and II, only correndonuclease I can degrade ssDNA
-
endonucleolytic cleavage near pyrimidine dimers to products with 5'-phosphate
for DNA repair the combined action of Py-Py correndonuclease I and II is necessary
-
endonucleolytic cleavage near pyrimidine dimers to products with 5'-phosphate
2-step mechanism, pyrimidine dimer-DNA glycosylase and an apurinic/apyrimidinic endonuclease
Tequatrovirus T4
-
170694, 170695, 170697, 170698, 170699, 170700, 170701, 170703, 170706, 170713, 170714
endonucleolytic cleavage near pyrimidine dimers to products with 5'-phosphate
processive
-
endonucleolytic cleavage near pyrimidine dimers to products with 5'-phosphate
processive
Tequatrovirus T4
-
endonucleolytic cleavage near pyrimidine dimers to products with 5'-phosphate
beta-elimination mechanism, imino intermediate
-
endonucleolytic cleavage near pyrimidine dimers to products with 5'-phosphate
beta-elimination mechanism, imino intermediate
Tequatrovirus T4
-
endonucleolytic cleavage near pyrimidine dimers to products with 5'-phosphate
damaged DNA substrate recognition mechanism, 2 distinct catalytic activities: cleavage of the glycosyl bond at the 5'side of pyrimidine dimer and subsequent scission of the phosphodiester bond at the 3' position of an abasic site through beta-elimination, the enzyme also scans nontarget sequences to search for lesions in DNA duplexes, glycosylase active site involves the catalytic residues Arg3, Glu23, Arg22, and Arg26 and the amino terminus which forms an imino-covalent intermediate with C1' of the 5' side of the thymidine-dimer
Tequatrovirus T4
-
endonucleolytic cleavage near pyrimidine dimers to products with 5'-phosphate
substrate recognition mechanism: 2 flexible loops are involved in binding and scanning along DNA duplex to search for thymidine dimers within UV-damaged DNA, residues Arg22, Glu23, Thr88 are involved in DNA binding and catalysis, and the regions of Lys45-Phe60 and Lys86-Asp92 are involved in DNA binding and scanning
Tequatrovirus T4
endonucleolytic cleavage near pyrimidine dimers to products with 5'-phosphate
reaction mechanisms of UvrA, UvrB, and UvrC
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
bacteriophage lambda DNA + H2O
oligonucleotides
-
UV irradiated
-
?
ColE1 DNA + H2O
oligonucleotides
Tequatrovirus T4
-
UV-irradiated, superhelical
-
?
damaged DNA containing nucleotide cross-links + H2O
?
DNA 14mer containing a TT-dimer + H2O
?
Tequatrovirus T4
-
-
-
-
?
DNA 18mer containing a TT-dimer + H2O
?
Tequatrovirus T4
-
-
-
-
?
DNA containing apurinic/apyrimidinic sites + H2O
?
DNA with a C8 guanine adduct of N-acetyl-2-aminofluorene + H2O
?
-
-
-
-
?
DNA with gamma-radiation-induced cross-linked guanine-thymine tandem lesion G[8,5-Me]T + H2O
?
-
the DNA substrate contains a covalent bond between C8 of the guanine and the 5-methyl carbon of the 3'-thymine, formed by X-radiation
-
-
?
DNA with gamma-radiation-induced cross-linked thymine-thymine lesion T[6,4]T + H2O
?
-
6-4 pyrimidine-pyrimidone photoproduct
-
-
?
dsDNA + H2O
?
Tequatrovirus T4
-
excision of cyclobutane pyrimidine dimers TT and TU, the latter being a cis-syn cyclobutane thymine-uracil dimer, produced within duplex DNA by UV radiation with equal efficiency, U is derived from C which becomes deaminated by UV radiation
-
-
?
E. coli DNA + H2O
oligonucleotides
E. coli plasmid DNA
oligonucleotides
Tequatrovirus T4
-
UV-irradiated
-
?
glycosylated DNA + H2O
oligonucleotides
Tequatrovirus T4
-
UV-irradiated, cleaves also nonglycosylated DNA
-
?
Haemophilus influenzae DNA + H2O
oligonucleotides
-
UV irradiated
-
?
M-13 DNA + H2O
oligonucleotides
Tequatrovirus T4
-
UV-irradiated, single-stranded DNA
-
?
Micrococcus luteus DNA + H2O
oligonucleotides
-
UV irradiated
-
?
native DNA + H2O
oligonucleotides
oligodeoxyribonucleotides
oligonucleotides
oligonucleotide DNA + H2O
?
pBR322 DNA + H2O
oligonucleotides
PBS1 DNA
oligonucleotides
poly(dA)-poly(dT) + H2O
oligonucleotides
poly(dI)-poly(dC) + H2O
oligonucleotides
-
UV irradiated, in 50 mM phosphate or 10 mM Tris-HCl supplemented with 100 mM NaCl
-
?
SPO1 DNA
oligonucleotides
supercoiled DNA + H2O
?
-
-
-
-
?
superhelical DNA + H2O
oligonucleotides
Tequatrovirus T4
-
UV-irradiated, cleaves also linear DNA
-
?
T4 DNA
oligonucleotides
Tequatrovirus T4
-
UV-irradiated
-
?
T7 DNA + H2O
oligonucleotides
Tequatrovirus T4
-
UV-irradiated
-
?
UV-damaged DNA containing cyclobutane pyrimidine dimers
?
UV-radiation damaged DNA + H2O
?
UV-radiation damaged PM2 phage DNA + H2O
?
additional information
?
-
damaged DNA containing nucleotide cross-links + H2O
?
-
initiation of nucleotide excision repair of DNA-polypeptide cross-links by the UvrABC nuclease
-
-
?
damaged DNA containing nucleotide cross-links + H2O
?
-
initiation of nucleotide excision repair of DNA-polypeptide cross-links by the UvrABC nuclease, engineering of DNA-peptide or DNA-protein cross-links via linkage at an acrolein-derived gamma-hydroxypropanodeoxyguanosine adduct and an apurinic/apyrimidinic site, the linked peptides are KWKK and KFHEKHHSHRGY, and the protein is the 16 kDa T4 pyrimidine dimer glycosylase/apurinic/apyrimidinic site lyase, incision at the eighth phosphodiester bond 5' of the lesion
-
-
?
damaged DNA containing nucleotide cross-links + H2O
?
-
initiation of nucleotide excision repair of DNA-polypeptide cross-links by the UvrABC nuclease
-
-
?
damaged DNA containing nucleotide cross-links + H2O
?
-
initiation of nucleotide excision repair of DNA-polypeptide cross-links by the UvrABC nuclease, engineering of DNA-peptide or DNA-protein cross-links via linkage at an acrolein-derived gamma-hydroxypropanodeoxyguanosine adduct and an apurinic/apyrimidinic site, the linked peptides are KWKK and KFHEKHHSHRGY, and the protein is the 16 kDa T4 pyrimidine dimer glycosylase/apurinic/apyrimidinic site lyase, incision at the eighth phosphodiester bond 5' of the lesion
-
-
?
DNA + H2O
?
-
-
-
-
?
DNA + H2O
?
Tequatrovirus T4
-
-
170694, 170695, 170696, 170697, 170698, 170699, 170700, 170701, 170702, 170703, 170704, 170705, 170706, 170712, 170713, 170714, 170715 -
-
?
DNA + H2O
?
Tequatrovirus T4
-
application of the enzyme to humans suffering the disease xeroderma pigmentosum due to DNA damage by UV radiation reverses the defective repair in these cells, the enzyme influences DNA repair, mutagenesis, and cell signaling, enhanced DNA repair of cyclobutane pyrimidine dimers changes the biological response to UV-B radiation, overview
-
-
?
DNA + H2O
?
Tequatrovirus T4
-
first reaction step of the repair pathway to excise pyrimidine-dimers
-
-
?
DNA + H2O
?
Tequatrovirus T4
-
excision of pyrimidine dimers produced within duplex DNA by UV radiation
-
-
?
DNA + H2O
?
Tequatrovirus T4
excision of pyrimidine dimers produced within duplex DNA by UV radiation, specific for thymine-dimers, interaction with wild-type and duplex DNA, overview
-
-
?
DNA + H2O
?
Tequatrovirus T4
-
excision of thymine dimers produced within duplex DNA by UV radiation
-
-
?
DNA containing apurinic/apyrimidinic sites + H2O
?
-
the enzyme is endonucleolytically active on AP sites generated from pyrimidine dimers cleaving phosphodiester bonds of the damaged DNAs with broad specificity
-
-
?
DNA containing apurinic/apyrimidinic sites + H2O
?
-
the enzyme is endonucleolytically active on AP sites generated from pyrimidine dimers cleaving phosphodiester bonds of the damaged DNAs with broad specificity
-
-
?
E. coli DNA + H2O
oligonucleotides
-
UV-irradiated dsDNA
-
?
E. coli DNA + H2O
oligonucleotides
-
UV-irradiated dsDNA
-
?
E. coli DNA + H2O
oligonucleotides
Tequatrovirus T4
-
-
-
?
E. coli DNA + H2O
oligonucleotides
Tequatrovirus T4
-
single-stranded DNA
-
?
E. coli DNA + H2O
oligonucleotides
Tequatrovirus T4
-
single-stranded DNA
-
?
E. coli DNA + H2O
oligonucleotides
Tequatrovirus T4
-
UV-irradiated dsDNA
-
?
E. coli DNA + H2O
oligonucleotides
Tequatrovirus T4
-
UV-irradiated dsDNA
-
?
native DNA + H2O
oligonucleotides
Tequatrovirus T4
-
E. coli DNA in vivo
-
?
native DNA + H2O
oligonucleotides
Tequatrovirus T4
-
E. coli DNA in vivo
-
?
oligodeoxyribonucleotides
oligonucleotides
-
dimer containing 49mer
-
?
oligodeoxyribonucleotides
oligonucleotides
-
50-bp
-
?
oligodeoxyribonucleotides
oligonucleotides
Tequatrovirus T4
-
UV-irradiated, 14mer and 18mer, single-stranded oligomers are a poorer substrate than the corresponding duplexes
-
?
oligodeoxyribonucleotides
oligonucleotides
Tequatrovirus T4
-
14mer containing a TT-dimer, duplex
-
?
oligonucleotide DNA + H2O
?
-
-
-
-
?
oligonucleotide DNA + H2O
?
-
-
-
-
?
pBR322 DNA + H2O
oligonucleotides
Tequatrovirus T4
-
UV-irradiated
-
?
pBR322 DNA + H2O
oligonucleotides
Tequatrovirus T4
-
UV-irradiated
-
?
PBS1 DNA
oligonucleotides
Tequatrovirus T4
-
UV irradiated, contains uracil instead of thymine
-
?
PBS1 DNA
oligonucleotides
Tequatrovirus T4
-
UV irradiated, contains uracil instead of thymine
-
?
poly(dA)-poly(dT) + H2O
oligonucleotides
-
in Tris buffer
-
-
?
poly(dA)-poly(dT) + H2O
oligonucleotides
Tequatrovirus T4
-
poly(dA)-poly(dT,dU) treated with uracil-DNA glycosylase, endonuclease acts specifically on double-strands
-
?
poly(dA)-poly(dT) + H2O
oligonucleotides
Tequatrovirus T4
-
UV-irradiated
-
?
poly(dA)-poly(dT) + H2O
oligonucleotides
Tequatrovirus T4
-
UV-irradiated
-
?
poly(dA)-poly(dT) + H2O
oligonucleotides
Tequatrovirus T4
-
UV-irradiated
length is less than 15 nucleotides
?
SPO1 DNA
oligonucleotides
Tequatrovirus T4
-
UV irradiated, contains 5-hydroxymethyluracil instead of thymine
-
?
SPO1 DNA
oligonucleotides
Tequatrovirus T4
-
UV irradiated, contains 5-hydroxymethyluracil instead of thymine
-
?
UV-damaged DNA containing cyclobutane pyrimidine dimers
?
Tequatrovirus T4
-
the T4 enzyme, in so called T4N5 liposomes, repairs UV radiation-induced cyclobutane pyrimidine dimers in DNA of epidermal dendritic cells of human skin which reduces the infiltration of macrophages into irradiated human epidermis and leads to memory immunosuppression in humans, overview
-
-
?
UV-damaged DNA containing cyclobutane pyrimidine dimers
?
Tequatrovirus T4
-
the T4 enzyme, in so called T4N5 liposomes, repairs UV radiation-induced cyclobutane pyrimidine dimers in DNA of epidermal dendritic cells of human skin
-
-
?
UV-radiation damaged DNA + H2O
?
-
the enzyme endonucleolytically nicks UV-irradiated DNA and cleaves phosphodiester bonds of the damaged DNAs with broad substrate specificity, higher activity with supercoiled, damaged DNA compared to relaxed, damaged DNA
-
-
?
UV-radiation damaged DNA + H2O
?
-
the enzyme is endonucleolytically nicks UV-irradiated DNA and cleaving phosphodiester bonds of the damaged DNAs with broad substrate specificity, higher activity with supercoiled, damaged DNA compared to relaxed, damaged DNA
-
-
?
UV-radiation damaged PM2 phage DNA + H2O
?
-
the DNA contains thymine glycol
-
-
?
UV-radiation damaged PM2 phage DNA + H2O
?
-
the DNA contains thymine glycol
-
-
?
X174 DNA + H2O
RFII
-
-
-
?
X174 DNA + H2O
RFII
-
UV-irradiated, denatured DNA: substrate for Py-Py correndonuclease I only
-
?
X174 DNA + H2O
RFII
-
UV irradiated RFI of phage X174 containing apurinic sites
-
?
X174 DNA + H2O
RFII
-
UV irradiated RFI of phage X174 containing apurinic sites
-
?
X174 DNA + H2O
RFII
-
UV irradiated RFI of phage X174 containing apurinic sites
-
?
X174 DNA + H2O
RFII
Tequatrovirus T4
-
UV irradiated RFI of phage X174 containing apurinic sites
RFII, i.e. nicked circular DNA
?
additional information
?
-
-
the enzyme is involved in nucleotide excision repair of damaged DNA removing various types of bulky and distorting DNA adducts induced by UV radiation, process initiation is performed by UvrA, nicking by UvrB, which also recruits UvrC that catalyzes both the 3' and 5' incisions
-
-
?
additional information
?
-
-
the enzyme is involved in nucleotide excision repair of damaged DNA removing various types of bulky and distorting DNA adducts induced by UV radiation, process initiation is performed by UvrA, nicking by UvrB, which also recruits UvrC that catalyzes both the 3' and 5' incisions, substrate recognition and reaction mechanism, overview
-
-
?
additional information
?
-
-
enzyme detects apurinic/apyrimidinic site base paired with adenine
-
-
?
additional information
?
-
-
enzyme detects cyclobutane pyrimidine dimers (DNA lesions) caused by UVA irradiation
-
-
?
additional information
?
-
-
UVA light directly generates a significant number of cyclobutane pyrimidine dimers as detected by a combined action of endonuclease IV and T4 endonuclease V
-
-
?
additional information
?
-
-
not: OsO4-treated DNA
-
-
?
additional information
?
-
-
not: x-irradiated, psoralen-crosslinked or alkylated DNA
-
-
?
additional information
?
-
-
not: x-irradiated, psoralen-crosslinked or alkylated DNA
-
-
?
additional information
?
-
-
not: substrates containing a trans-syn-I, (6-4), or Dewar thymine dimer, a 5,6-dihydrouracil lesion or an A:G or A:C mismatch
-
-
?
additional information
?
-
-
the enzyme initiates repair of deaminated bases in damaged DNA by making a nucleolytic incision one nucleotide away from the 3' side of the lesion
-
-
?
additional information
?
-
-
substrate specificity, the enzyme performs single-turnover on cleavage of double-stranded or single-stranded deoxynucleotide-containing DNA, the enzyme cleaves deoxyinosine- or deoxyxanthosine-containing DNA with similar nicking activity for the substrates, tight binding to nicking products, deoxyuridine-containing DNA is only slightly acepted as substrate when it is in excess, the active site of the enzyme can accomodate pyrimidine-containing mismatches, the plastic nature of the active site allows the enzyme to enfold both pyrimidine and purine deaminated lesions or base pair mismatches, overview
-
-
?
additional information
?
-
-
the enzyme initiates repair of deaminated bases in damaged DNA by making a nucleolytic incision one nucleotide away from the 3' side of the lesion
-
-
?
additional information
?
-
-
substrate specificity, the enzyme performs single-turnover on cleavage of double-stranded or single-stranded deoxynucleotide-containing DNA, the enzyme cleaves deoxyinosine- or deoxyxanthosine-containing DNA with similar nicking activity for the substrates, tight binding to nicking products, deoxyuridine-containing DNA is only slightly acepted as substrate when it is in excess, the active site of the enzyme can accomodate pyrimidine-containing mismatches, the plastic nature of the active site allows the enzyme to enfold both pyrimidine and purine deaminated lesions or base pair mismatches, overview
-
-
?
additional information
?
-
Tequatrovirus T4
-
not: unirradiated or heat-denatured DNA
-
-
?
additional information
?
-
Tequatrovirus T4
-
not: 5-thyminyl-5,6-dihydrothymine-containing DNA
-
-
?
additional information
?
-
Tequatrovirus T4
-
not: 5-thyminyl-5,6-dihydrothymine-containing DNA
-
-
?
additional information
?
-
Tequatrovirus T4
-
not: DNA exposed to ionizing radiation, methyl methane sulfonate, nitrogen mustard, mitomycin C, 4-nitroquinoline-1-oxide
-
-
?
additional information
?
-
Tequatrovirus T4
-
not: DNA damaged by 4-nitroquinoline-N-oxide or methyl methanesulfonate
-
-
?
additional information
?
-
Tequatrovirus T4
-
psoralen-mediated interstrand cross-links
-
-
?
additional information
?
-
Tequatrovirus T4
enzyme binds to wild-type and damaged DNA
-
-
?
additional information
?
-
Tequatrovirus T4
-
synthesis of cis-syn cyclobutane thymine-uracil dimer, determination of cyclobutane dimer structure by NMR spectroscopy
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Ca2+
-
inhibits both Py-Py correndonucleases
CH2O
Tequatrovirus T4
-
total inhibition if 4.4 methylations per molecule are present
EDTA
-
inhibits Py-Py correndonuclease II at concentrations above 20 mM
KCl
-
Py-Py correndonuclease II loses 75% of activity in presence of 100 mM
NaCNBH3
Tequatrovirus T4
-
total inhibition if 4.4 methylations per molecule are present
p-chloromercuribenzoate
Tequatrovirus T4
-
70-80% inhibition in presence of 0.0004 M
p-chloromercuriphenylsulfonic acid
Tequatrovirus T4
-
20-25% inhibition in presence of 0.0001 M
Zn2+
-
inhibits both Py-Py correndonucleases
Mg2+
-
inhibits the enzyme activity with DNA containing apurinic/apyrimidinic sites, but not with UV-radiation damaged DNA
Mg2+
-
Py-Py correndonuclease II loses 75% of activity in presence of 15 mM
Mg2+
-
inhibits the enzyme activity with DNA containing apurinic/apyrimidinic sites, but not with UV-radiation damaged DNA
Mg2+
Tequatrovirus T4
-
in presence of 10 mM MgCl2: 10% of the activity observed in presence of 10 mM EDTA
NaBH4
-
complexes are formed at a concentration of more than 10 mM NaBH4; leads to a covalently linked enzyme-substrate product
NaBH4
Tequatrovirus T4
-
inhibits degradation of the glycosylase product, reduces aldehyde moiety of the apyrimidinic sites to alcohol which results in resistance to endonuclease
NaBH4
Tequatrovirus T4
-
leads to a covalently linked enzyme-substrate product
NaCl
-
Py-Py correndonuclease II loses 75% of activity in presence of 100 mM
NaCl
Tequatrovirus T4
-
inhibits endonuclease activity
NaCN
-
50% inhibition occurs in presence of around 6 mM NaCN; reacts with imino intermediate
NaCN
Tequatrovirus T4
-
reacts with imino intermediate
additional information
-
the enzyme is sensitive to high salt concentrations
-
additional information
Tequatrovirus T4
-
endonuclease activity not affected by: -SH-group inhibitors, caffeine, tRNA
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Acute Lung Injury
Ribosomal Protein S3 Gene Silencing Protects Against Cigarette Smoke-Induced Acute Lung Injury.
Adenocarcinoma
Differential gene expression in human lung adenocarcinomas and squamous cell carcinomas.
Asthma
Ribosomal protein S3 gene silencing protects against experimental allergic asthma.
Atypical Squamous Cells of the Cervix
MoSnt2-dependent deacetylation of histone H3 mediates MoTor-dependent autophagy and plant infection by the rice blast fungus Magnaporthe oryzae.
Bacterial Infections
Ribosomal protein s3: a multifunctional target of attaching/effacing bacterial pathogens.
Bacterial Infections
SseL Deubiquitinates RPS3 to Inhibit Its Nuclear Translocation.
Breast Neoplasms
Evaluation of the association of heterozygous germline variants in NTHL1 with breast cancer predisposition: an international multi-center study of 47,180 subjects.
Breast Neoplasms
Ribosomal protein S3 regulates XIAP expression independently of the NF-?B pathway in breast cancer cells.
Carcinogenesis
Formation of trans-4-hydroxy-2-nonenal- and other enal-derived cyclic DNA adducts from omega-3 and omega-6 polyunsaturated fatty acids and their roles in DNA repair and human p53 gene mutation.
Carcinoma
Chemoprevention of nonmelanoma skin cancer.
Carcinoma
Differential gene expression in human lung adenocarcinomas and squamous cell carcinomas.
Carcinoma
Measurement of oxidative DNA damage induced by mainstream cigarette smoke in cultured NCI-H292 human pulmonary carcinoma cells.
Carcinoma
T4 endonuclease V: review and application to dermatology.
Carcinoma, Basal Cell
Chemoprevention of nonmelanoma skin cancer.
Carcinoma, Basal Cell
T4 endonuclease V: review and application to dermatology.
Carcinoma, Non-Small-Cell Lung
Phosphorylation of ribosomal protein S3 and antiapoptotic TRAF2 protein mediates radioresistance in non-small cell lung cancer cells.
Carcinoma, Squamous Cell
Differential gene expression in human lung adenocarcinomas and squamous cell carcinomas.
Cockayne Syndrome
Cyclobutane pyrimidine dimers do not fully explain the mutagenicity induced by UVA in Chinese hamster cells.
Cockayne Syndrome
Defective repair of 5-hydroxy-2'-deoxycytidine in Cockayne syndrome cells and its complementation by Escherichia coli formamidopyrimidine DNA glycosylase and endonuclease III.
Cockayne Syndrome
Oxidatively damaged DNA repair defect in cockayne syndrome and its complementation by heterologous repair proteins.
Cockayne Syndrome
The basal levels of 8-oxoG and other oxidative modifications in intact mitochondrial DNA are low even in repair-deficient (Ogg1(-/-)/Csb(-/-)) mice.
Colonic Neoplasms
Ribosomal protein S3 selectively affects colon cancer growth by modulating the levels of p53 and lactate dehydrogenase.
deoxyribonuclease (pyrimidine dimer) deficiency
Pathogen DNA as target for host-generated oxidative stress: role for repair of bacterial DNA damage in Helicobacter pylori colonization.
Dermatitis, Contact
Pyrimidine dimers in DNA initiate systemic immunosuppression in UV-irradiated mice.
Erythema
Topical treatment with liposomes containing T4 endonuclease V protects human skin in vivo from ultraviolet-induced upregulation of interleukin-10 and tumor necrosis factor-alpha.
Fanconi Anemia
Chromosomal instability of fanconi anemia cells is not the consequence of a defective repair activity of the ribosomal protein S3.
Fibrosarcoma
Reduction of invasion in human fibrosarcoma cells by ribosomal protein S3 in conjunction with Nm23-H1 and ERK.
Heart Failure
A novel mtDNA repair fusion protein attenuates maladaptive remodeling and preserves cardiac function in heart failure.
Hepatitis
Evidence of alterations in base excision repair of oxidative DNA damage during spontaneous hepatocarcinogenesis in Long Evans Cinnamon rats.
Ichthyosis
Effect of topically applied T4 endonuclease V in liposomes on skin cancer in xeroderma pigmentosum: a randomised study. Xeroderma Pigmentosum Study Group.
Infections
Pathogen DNA as target for host-generated oxidative stress: role for repair of bacterial DNA damage in Helicobacter pylori colonization.
Infections
Removal of T4 endonuclease V-sensitive sites from SV40 DNA after exposure to ultraviolet light.
Keratosis, Actinic
Chemoprevention of nonmelanoma skin cancer.
Keratosis, Actinic
DNA repair, immunosuppression, and skin cancer.
Keratosis, Actinic
T4 endonuclease V: review and application to dermatology.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Puncta intended: connecting the dots between autophagy and cell stress networks.
Lung Injury
Mitochondrial Targeted Endonuclease III DNA Repair Enzyme Protects against Ventilator Induced Lung Injury in Mice.
Lung Neoplasms
Phosphorylation of ribosomal protein S3 and antiapoptotic TRAF2 protein mediates radioresistance in non-small cell lung cancer cells.
Lung Neoplasms
RNF138-mediated ubiquitination of rpS3 is required for resistance of glioblastoma cells to radiation-induced apoptosis.
Lymphoma
Different roles of Fpg and Endo III on catechol-induced DNA damage in extended-term cultures of human lymphocytes and L5178Y mouse lymphoma cells.
Melanoma
Enhancement of DNA repair using topical T4 endonuclease V does not inhibit melanoma formation in Cdk4/Tyr-Nras mice following neonatal UVR.
Melanoma
Melanoma chemoprevention.
Melanoma
RPS3 regulates melanoma cell growth and apoptosis by targeting Cyto C/Ca2+/MICU1 dependent mitochondrial signaling.
Melanoma
Treatment of human melanocytes and S91 melanoma cells with the DNA repair enzyme T4 endonuclease V enhances melanogenesis after ultraviolet irradiation.
Neoplasm Metastasis
Changes of Ribosomal Protein S3 Immunoreactivity and Its New Expression in Microglia in the Mice Hippocampus After Lipopolysaccharide Treatment.
Neoplasm Metastasis
Dissociation of MIF-rpS3 complex and sequential NF-?B activation is involved in IR-induced metastatic conversion of NSCLC.
Neoplasm Metastasis
New role of human ribosomal protein S3: Regulation of cell cycle via phosphorylation by cyclin-dependent kinase 2.
Neoplasms
A novel TLR4 binding protein, 40S ribosomal protein S3, has potential utility as an adjuvant in a dendritic cell-based vaccine.
Neoplasms
Fucosylated Proteome Profiling Identifies a Fucosylated, Non-Ribosomal, Stress-Responsive Species of Ribosomal Protein S3.
Neoplasms
Lung cancer in smoking patients inversely alters the activity of hOGG1 and hNTH1.
Neoplasms
Ribosomal protein S3 (rpS3) secreted from various cancer cells is N-linked glycosylated.
Neoplasms
Ribosomal protein S3 is secreted as a homodimer in cancer cells.
Neoplasms
Sequence specificity of Cr(III)-DNA adduct formation in the p53 gene: NGG sequences are preferential adduct-forming sites.
Neoplasms
Strand-specific removal of cyclobutane pyrimidine dimers from the p53 gene in the epidermis of UVB-irradiated hairless mice.
Neoplasms
The human endonuclease III enzyme is a relevant target to potentiate cisplatin cytotoxicity in Y-box-binding protein-1 overexpressing tumor cells.
Neoplasms
Topical treatment with liposomes containing T4 endonuclease V protects human skin in vivo from ultraviolet-induced upregulation of interleukin-10 and tumor necrosis factor-alpha.
Neoplasms
Topical treatment with OGG1 enzyme affects UVB-induced skin carcinogenesis.
Osteosarcoma
Ribosomal protein S3 regulates GLI2-mediated osteosarcoma invasion.
Ovarian Neoplasms
Puncta intended: connecting the dots between autophagy and cell stress networks.
Photosensitivity Disorders
Increased base change mutations at G:C pairs in Escherichia coli deficient in endonuclease III and VIII.
Plague
Glutathionylation of Yersinia pestis LcrV and Its Effects on Plague Pathogenesis.
Reperfusion Injury
A novel mtDNA repair fusion protein attenuates maladaptive remodeling and preserves cardiac function in heart failure.
Sarcoma
Escherichia coli virulence protein NleH1 interaction with the v-Crk sarcoma virus CT10 oncogene-like protein (CRKL) governs NleH1 inhibition of the ribosomal protein S3 (RPS3)/nuclear factor ?B (NF-?B) pathway.
Skin Neoplasms
DNA repair, immunosuppression, and skin cancer.
Skin Neoplasms
Effect of topically applied T4 endonuclease V in liposomes on skin cancer in xeroderma pigmentosum: a randomised study. Xeroderma Pigmentosum Study Group.
Skin Neoplasms
Measurement of UVB-Induced DNA damage and its consequences in models of immunosuppression.
Skin Neoplasms
Topical treatment with OGG1 enzyme affects UVB-induced skin carcinogenesis.
Starvation
Phosphorylated and other modified forms of eukaryotic ribosomal protein S3 analysed by two-dimensional gel electrophoresis.
Sunburn
SKH-1 hairless mice repair UV-induced pyrimidine dimers in epidermal DNA.
Sunburn
Topical treatment with liposomes containing T4 endonuclease V protects human skin in vivo from ultraviolet-induced upregulation of interleukin-10 and tumor necrosis factor-alpha.
Triple Negative Breast Neoplasms
Puncta intended: connecting the dots between autophagy and cell stress networks.
Tuberous Sclerosis
Identification of functional elements in the bidirectional promoter of the mouse Nthl1 and Tsc2 genes.
Ventilator-Induced Lung Injury
Mitochondrial Targeted Endonuclease III DNA Repair Enzyme Protects against Ventilator Induced Lung Injury in Mice.
Xeroderma Pigmentosum
A cell-free assay measuring repair DNA synthesis in human fibroblasts.
Xeroderma Pigmentosum
DNA repair synthesis in human fibroblasts requires DNA polymerase delta.
Xeroderma Pigmentosum
Effect of topically applied T4 endonuclease V in liposomes on skin cancer in xeroderma pigmentosum: a randomised study. Xeroderma Pigmentosum Study Group.
Xeroderma Pigmentosum
Enhanced DNA repair of cyclobutane pyrimidine dimers changes the biological response to UV-B radiation.
Xeroderma Pigmentosum
Enhancement of ultraviolet-DNA repair in denV gene transfectants and T4 endonuclease V-liposome recipients.
Xeroderma Pigmentosum
Low-level DNA exchanges in normal human and xeroderma pigmentosum cells after UV irradiation.
Xeroderma Pigmentosum
Measurement of UVB-Induced DNA damage and its consequences in models of immunosuppression.
Xeroderma Pigmentosum
Microinjection of T4 endonuclease V produced by a synthetic denV gene stimulates unscheduled DNA synthesis in both xeroderma pigmentosum and normal cells.
Xeroderma Pigmentosum
Phage T4 endonuclease V stimulates DNA repair replication in isolated nuclei from ultraviolet-irradiated human cells, including xeroderma pigmentosum fibroblasts.
Xeroderma Pigmentosum
Restoration of ultraviolet-induced unscheduled DNA synthesis of xeroderma pigmentosum cells by the concomitant treatment with bacteriophage T4 endonuclease V and HVJ (Sendai virus).
Xeroderma Pigmentosum
Specific action of T4 endonuclease V on damaged DNA in xeroderma pigmentosum cells in vivo.
Xeroderma Pigmentosum
Therapeutics of xeroderma pigmentosum: A PRISMA-compliant systematic review.
Xeroderma Pigmentosum
[Restoration of ultraviolet-induced unsceduled DNA synthesis of xeroderma pigmentosum cells by insertion of T4 endonuclease V utilizing HVJ (AUTHOR'S TRANSL)]
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
A26Q
Tequatrovirus T4
-
not processive
A3D
Tequatrovirus T4
-
AP-specific nicking possible, low level of dimer specific nicking
A3E
Tequatrovirus T4
-
AP-specific nicking possible, low level of dimer specific nicking
A3K
Tequatrovirus T4
-
substantial level of AP- and dimer specific nicking, not processive
A3L
Tequatrovirus T4
-
substantial level of AP- and dimer specific nicking, not processive
A3Q
Tequatrovirus T4
-
substantial level of AP- and dimer specific nicking, not processive
DELTAC127
Tequatrovirus T4
-
C127-truncated, total loss of activity
G133D
Tequatrovirus T4
-
impaired ability to bind dimer-containing DNA
K130L
Tequatrovirus T4
-
almost same activity as wild-type
K33Q
Tequatrovirus T4
-
in combination with A26Q, not processive
R3Q
Tequatrovirus T4
-
active site mutant, retains full substrate binding ability but shows complex structure differences, crystal structure determination with a bound DNA duplex in comparison to the wild-type enzyme
T127M
Tequatrovirus T4
-
almost same activity as wild-type, Km value in the same order as that of wild-type
T2P
Tequatrovirus T4
-
lack of dimer-specific glycosylase and nicking activity
T2S
Tequatrovirus T4
-
wild-type level of dimer-specific glycosylase and nicking activity
T2V
Tequatrovirus T4
-
intermediate activity level of dimer-specific glycosylase and nicking activity
W128A
Tequatrovirus T4
-
total loss of activity
Y129A
Tequatrovirus T4
-
total loss of activity
Y131A
Tequatrovirus T4
-
only slight activity remains
Y132A
Tequatrovirus T4
-
only slight activity remains
D35A
-
site-directed mutagenesis, the mutant shows no deoxyinosine cleavage activity
D35A
-
site-directed mutagenesis, the mutant shows no deoxyinosine cleavage activity
-
E23D
Tequatrovirus T4
-
no detectable N-glycosylase activity on pyrimidine dimers, partial retention of AP-lyase activity
E23D
Tequatrovirus T4
-
active site mutant, retains full substrate binding ability but shows complex structure differences, crystal structure determination with a bound DNA duplex in comparison to the wild-type enzyme
E23Q
Tequatrovirus T4
-
no detectable N-glycosylase activity on pyrimidine dimers, loss of AP-lyase activity
E23Q
Tequatrovirus T4
-
active site mutant, retains full substrate binding ability but shows complex structure differences, crystal structure determination with a bound DNA duplex in comparison to the wild-type enzyme
E23Q
Tequatrovirus T4
enzyme mutant-substrate complex structure
K130G
Tequatrovirus T4
-
diminished capacity to make complete incisions, significantly decreased intracellular accumulation
K130G
Tequatrovirus T4
-
low dimer-specific binding activity, AP-endonuclease function several times as efficient as that of the wild-type
K130H
Tequatrovirus T4
-
diminished capacity to make complete incisions, slight decreased intracellular accumulation
K130H
Tequatrovirus T4
-
low dimer-specific binding activity, wild-type lyase activity, reduced glycosylase activity
W128S
Tequatrovirus T4
-
only slight activity remains
W128S
Tequatrovirus T4
-
wild-type glycosylase but virtually no AP-lyase activity
Y129N
Tequatrovirus T4
-
-
Y129N
Tequatrovirus T4
-
dimer-specific binding and nicking abolished, apurinic-specific nicking abolished
Y131N
Tequatrovirus T4
-
in combination with Y129N, dimer-specific binding and nicking abolished, ability for apurinic-specific nicking retained
Y131N
Tequatrovirus T4
-
in combination with Y129N, wild-type lyase activity retained, diminished dimer-specific binding and N-glycosylase activity
additional information
Tequatrovirus T4
-
deletion of Arg 3, only marginal level of AP specificity, no other detectable activity
additional information
Tequatrovirus T4
-
insertion of Gly between the first 2 amino acids, lack of dimer-specific glycosylase and nicking activity
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-12°C, in 12% glycerol, inactivates the enzyme
Tequatrovirus T4
-
-20°C, addition of an equal value of glycerol
Tequatrovirus T4
-
-20°C, addition of an equal value of glycerol, 1 ml aliquots
-
-20°C, in 50% glycerol, complete inactivation in 3-4 weeks
-
-70C, purified enzyme, 20 mM Tris-HCl, pH 8.0, 0.1 mM EDTA, 0.01% Triton X-100, 50 mM KCl, 6 months, loss of 55% activity
4°C, in 10 mM Tris-HCl buffer, pH 8.0, with 3% polyethylene glycol and 0.1 mM EDTA
Tequatrovirus T4
-
4°C, in 50 mM Tris-HCl, pH 7.5, containing 10% ethylene glycol or 3% polyethylene glycol, storage for several months
Tequatrovirus T4
-
4°C, stock enzyme-containing cell extracts
Tequatrovirus T4
-
freezing, leads to inactivation
Tequatrovirus T4
-
in liquid nitrogen, for minimal inactivation
-
in liquid nitrogen, for minimal inactivation, freeze-thawing does not inactivate either Py-Py correndonuclease
-
-70C, purified enzyme, 20 mM Tris-HCl, pH 8.0, 0.1 mM EDTA, 0.01% Triton X-100, 50 mM KCl, 6 months, loss of 55% activity
-
-70C, purified enzyme, 20 mM Tris-HCl, pH 8.0, 0.1 mM EDTA, 0.01% Triton X-100, 50 mM KCl, 6 months, loss of 55% activity
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Nakabeppu, Y.; Yamashita, K.; Sekiguchi, M.
Purification and characterization of normal and mutant forms of T4 endonuclease V
J. Biol. Chem.
257
2556-2562
1982
Tequatrovirus T4
brenda
Nakatsu, Y.; Nakabeppu, Y.; Sekiguchi, M.
Action of T4 endonuclease V on polydeoxyribonucleotides with apyrimidinic or apurinic sites
J. Biochem.
91
2057-2065
1982
Tequatrovirus T4
brenda
Minton, K.; Durphy, M.; Taylor, R.; Friedberg, E.C.
The ultraviolet endonuclease of bacteriophage T4. Further characterization
J. Biol. Chem.
250
2823-2829
1975
Tequatrovirus T4
brenda
Recinos , A.; Lloyd, R.S.
Site-directed mutagenesis of the T4 endonuclease V gene: role of lysine-130
Biochemistry
27
1832-1838
1988
Tequatrovirus T4
brenda
Stump, D.G.; Lloyd, R.S.
Site-directed mutagenesis of the T4 endonuclease V gene: role of tyrosine-129 and -131 in pyrimidine dimer-specific binding
Biochemistry
27
1839-1843
1988
Tequatrovirus T4
brenda
Morikawa, K.; Tsujimoto, M.; Ikehara, M.
Preliminary crystallographic study of pyrimidine dimer-specific excision-repair enzyme from bacteriophage T4
J. Mol. Biol.
202
683-684
1988
Tequatrovirus T4
brenda
Dowd, D.R.; Lloyd, R.S.
Site-directed mutagenesis of the T4 endonuclease V gene: the role of arginine-3 in the target search
Biochemistry
28
8699-8705
1989
Tequatrovirus T4
brenda
Gruskin, E.A.; Lloyd, R.S.
Molecular analysis of plasmid DNA repair within ultraviolet-irradiated Escherichia coli. I. T4 endonuclease V-initiated excision repair
J. Biol. Chem.
263
12728-12737
1988
Tequatrovirus T4
brenda
Inaoka, T.; Ishida, M.; Ohtsuka, E.
Affinity of single- or double-stranded oligodeoxyribonucleotides containing a thymine photodimer for T4 endonuclease V
J. Biol. Chem.
264
2609-2614
1989
Tequatrovirus T4
brenda
Ishida, M.; Kanamori, Y.; Hori, N.; Inaoka, T.; Ohtsuka, E.
In vitro and in vivo activities of T4 endonuclease V mutants altered in the C-terminal aromatic region
Biochemistry
29
3817-3821
1990
Tequatrovirus T4
brenda
Makino, F.; Tanooka, H.; Sekiguchi, M.
Action of T4 endonuclease V on DNA containing various photoproducts
J. Biochem.
82
1567-1573
1977
Tequatrovirus T4
brenda
Sato, K.; Sekiguchi, M.
Studies on temperature-dependent ultraviolet light-sensitive mutants of bacteriophage T4: the structural gene for T4 endonuclease V
J. Mol. Biol.
102
15-26
1976
Tequatrovirus T4
brenda
Nakabeppu, Y.; Sekiguchi, M.
Physical association of pyrimidine dimer DNA glycosylase and apurinic/apyrimidinic DNA endonuclease essential for repair of ultraviolet-damaged DNA
Proc. Natl. Acad. Sci. USA
78
2742-2746
1981
Tequatrovirus T4
brenda
Riazuddin, S.; Grossman, L.
Micrococcus luteus correndonucleases. I. resolution and purification of two endonucleases specific for DNA containing pyrimidine dimers
J. Biol. Chem.
252
6280-6286
1977
Micrococcus luteus
brenda
Riazuddin, S.; Grossman, L.
Micrococcus luteus correndonucleases. II. Mechanism of action of two endonucleases specific for DNA containing pyrimidine dimers
J. Biol. Chem.
252
6287-6293
1977
Micrococcus luteus
brenda
Riazuddin, S.; Grossman, L.
Micrococcus luteus correndonucleases. III. Evidence for involvement in repair in vivo of two endonucleases specific for DNA containing pyrimidine dimers
J. Biol. Chem.
252
6294-6298
1977
Micrococcus luteus
brenda
Braun, A.G.; Radman, M.; Grossman, L.
Enzymatic repair of DNA: Sites of hydrolysis by the Escherichia coli endonuclease specific for pyrimidine dimers (correndonuclease II)
Biochemistry
15
4116-4120
1976
Escherichia coli
brenda
Riazuddin, S.
Purification and properties of pyrimidine dimer specific endonucleases from Micrococcus luteus
Methods Enzymol.
65
185-191
1980
Micrococcus luteus
brenda
Friedberg, E.C.; Ganesan, A.K.; Seawell, P.C.
Purification and properties of a pyrimidine dimer-specific endonuclease from E. coli infected with bacteriophage T4
Methods Enzymol.
65
191-201
1980
Tequatrovirus T4
brenda
Valerie, K.
Replacing tryptophan-128 of T4 endonuclease V with a serine residue results in decreased enzymatic activity in vitro and in vivo
Nucleic Acids Res.
23
3764-3770
1995
Tequatrovirus T4
brenda
Latham, K.A.; Lloyd, R.S.
T4 endonuclease V, perspectives on catalysis
Ann. N. Y. Acad. Sci.
726
181-197
1994
Tequatrovirus T4
brenda
Kibitel, J.T.; Yee, V.; Yarosh, D.B.
Enhancment of ultraviolet-DNA repair in denV-gene transfectants and T4 endonuclease V-liposome recipients
Photochem. Photobiol.
54
753-760
1991
Tequatrovirus T4
brenda
Shiota, S.; Nakayama, H.
UV endonuclease of Micrococcus luteus, a cyclobutane pyrimidine dimer-DNA glycosylase/abasic lyase: Cloning and characterization of the gene
Proc. Natl. Acad. Sci. USA
94
593-598
1997
Micrococcus luteus
brenda
Piersen, C.E.; Prince, M.A.; Augustine, M.L.; Dodson, M.L.; Lloyd, R.S.
Purification and cloning of Micrococcus luteus ultraviolet endonuclease, an N-glycosylase/abasic lyase that proceeds via an imino enzyme-DNA intermediate
J. Biol. Chem.
270
23475-23484
1995
Micrococcus luteus
brenda
Ahn, H.C.; Ohkubo, T.; Iwai, S.; Morikawa, K.; Lee, B.J.
Interaction of T4 endonuclease V with DNA: importance of the flexible loop regions in protein-DNA interaction
J. Biol. Chem.
278
30985-30992
2003
Tequatrovirus T4 (P04418)
brenda
Morikawa, K.; Shirakawa, M.
Three-dimensional structural views of damaged-DNA recognition: T4 endonuclease V, E. coli Vsr protein, and human nucleotide excision repair factor XPA
Mutat. Res.
460
257-275
2000
Tequatrovirus T4
brenda
Yarosh, D.B.
Enhanced DNA repair of cyclobutane pyrimidine dimers changes the biological response to UV-B radiation
Mutat. Res.
509
221-226
2002
Tequatrovirus T4
brenda
Takasawa, K.; Masutani, C.; Hanaoka, F.; Iwai, S.
Chemical synthesis and translesion replication of a cis-syn cyclobutane thymine-uracil dimer
Nucleic Acids Res.
32
1738-1745
2004
Tequatrovirus T4
brenda
Kim Sang, H.; Lee Jae, Y.; Kim, J.
Characterization of a wide range base-damage-endonuclease activity of mammalian rpS3
Biochem. Biophys. Res. Commun.
328
962-967
2005
Homo sapiens, Mus musculus
brenda
Minko, I.G.; Kurtz, A.J.; Croteau, D.L.; Van Houten, B.; Harris, T.M.; Lloyd, R.S.
Initiation of repair of DNA-polypeptide cross-links by the UvrABC nuclease
Biochemistry
44
3000-3009
2005
[Bacillus] caldotenax, Thermotoga maritima
brenda
Feng, H.; Klutz, A.; Cao, W.
Active site plasticity of endonuclease V from Salmonella typhimurium
Biochemistry
44
675-683
2005
Salmonella enterica subsp. enterica serovar Typhimurium, Salmonella enterica subsp. enterica serovar Typhimurium 14028
brenda
Yang, Z.; Colis, L.C.; Basu, A.K.; Zou, Y.
Recognition and incision of gamma-radiation-induced cross-linked guanine-thymine tandem lesion G[8,5-Me]T by UvrABC nuclease
Chem. Res. Toxicol.
18
1339-1346
2005
Escherichia coli
brenda
Kuchel, J.M.; Barnetson, R.S.; Halliday, G.M.
Cyclobutane pyrimidine dimer formation is a molecular trigger for solar-simulated ultraviolet radiation-induced suppression of memory immunity in humans
Photochem. Photobiol. Sci.
4
577-582
2005
Tequatrovirus T4
brenda
Jiang, Y.; Rabbi, M.; Kim, M.; Ke, C.; Lee, W.; Clark, R.L.; Mieczkowski, P.A.; Marszalek, P.E.
UVA generates pyrimidine dimers in DNA directly
Biophys. J.
96
1151-1158
2009
Escherichia coli
brenda
Hacker, E.; Muller, H.K.; Hayward, N.; Fahey, P.; Walker, G.
Enhancement of DNA repair using topical T4 endonuclease V does not inhibit melanoma formation in Cdk4(R24C/R24C)/Tyr-Nras(Q61K) mice following neonatal UVR
Pigment Cell Melanoma Res.
23
121-128
2010
Mus musculus
brenda