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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
3-hydroxy-3-methylglutaryl-coa hydrolase, beta-hydroxy-beta-methylglutaryl coenzyme a hydrolase,
more
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3-hydroxy-3-methylglutaryl-CoA hydrolase
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beta-hydroxy-beta-methylglutaryl coenzyme A deacylase
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beta-hydroxy-beta-methylglutaryl coenzyme A hydrolase
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hydrolase, hydroxymethylglutaryl coenzyme A
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hydroxymethylglutaryl coenzyme A deacylase
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(S)-3-hydroxy-3-methylglutaryl-CoA + H2O = CoA + 3-hydroxy-3-methylglutarate
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hydrolysis of thioester
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(S)-3-hydroxy-3-methylglutaryl-CoA hydrolase
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(S)-3-hydroxy-3-methylglutaryl-CoA + H2O
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(S)-3-hydroxy-3-methylglutaryl-CoA + H2O
CoA + 3-hydroxy-3-methylglutarate
(S)-3-hydroxy-3-methylglutaryl-CoA + H2O
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(S)-3-hydroxy-3-methylglutaryl-CoA + H2O
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(S)-3-hydroxy-3-methylglutaryl-CoA + H2O
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(S)-3-hydroxy-3-methylglutaryl-CoA + H2O
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(S)-3-hydroxy-3-methylglutaryl-CoA + H2O
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(S)-3-hydroxy-3-methylglutaryl-CoA + H2O
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(S)-3-hydroxy-3-methylglutaryl-CoA + H2O
CoA + 3-hydroxy-3-methylglutarate
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(S)-3-hydroxy-3-methylglutaryl-CoA + H2O
CoA + 3-hydroxy-3-methylglutarate
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(S)-3-hydroxy-3-methylglutaryl-CoA + H2O
CoA + 3-hydroxy-3-methylglutarate
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(S)-3-hydroxy-3-methylglutaryl-CoA + H2O
CoA + 3-hydroxy-3-methylglutarate
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(S)-3-hydroxy-3-methylglutaryl-CoA + H2O
CoA + 3-hydroxy-3-methylglutarate
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(S)-3-hydroxy-3-methylglutaryl-CoA + H2O
CoA + 3-hydroxy-3-methylglutarate
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(S)-3-hydroxy-3-methylglutaryl-CoA + H2O
CoA + 3-hydroxy-3-methylglutarate
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(S)-3-hydroxy-3-methylglutaryl-CoA + H2O
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(S)-3-hydroxy-3-methylglutaryl-CoA + H2O
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(S)-3-hydroxy-3-methylglutaryl-CoA + H2O
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(S)-3-hydroxy-3-methylglutaryl-CoA + H2O
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(S)-3-hydroxy-3-methylglutaryl-CoA + H2O
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(S)-3-hydroxy-3-methylglutaryl-CoA + H2O
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(S)-3-hydroxy-3-methylglutaryl-CoA + H2O
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Starvation
Formation and utilization of 3-hydroxy-3-methylglutarate in liver mitochondria of starved and streptozotocin-diabetic rats.
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0.27 - 0.83
(S)-3-hydroxy-3-methylglutaryl-CoA
0.27
(S)-3-hydroxy-3-methylglutaryl-CoA
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microsomal
0.83
(S)-3-hydroxy-3-methylglutaryl-CoA
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soluble enzyme
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brenda
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brenda
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brenda
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brenda
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brenda
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brenda
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brenda
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brenda
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brenda
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brenda
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brenda
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brenda
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brenda
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brenda
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ACOT8_HUMAN
319
0
35914
Swiss-Prot
other Location (Reliability: 2)
ACOT8_MOUSE
320
0
35827
Swiss-Prot
other Location (Reliability: 1)
ACOT8_RAT
320
0
36003
Swiss-Prot
other Location (Reliability: 1)
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20
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without substrate, microsomal, 31% loss of activity after 15 min
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without substrate, cytoplasm, 25% loss of activity after 30 min, microsomal, 50% loss of activity after 5 min
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microsomal, 6 h stable
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-15°C, crude enzyme, 2 days, 40% loss of activity
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Sipat, A.B.; Sabine, J.R.
beta-hydroxy-beta-methylglutaryl coenzyme A hydrolase of rat liver
Biochim. Biophys. Acta
666
181-190
1981
Rattus norvegicus
brenda
Dekker, E.E.; Schlesinger, M.J.; Coon, M.
beta-Hydroxy-beta-methylglutaryl coenzyme A deacylase
J. Biol. Chem.
233
434-438
1958
Gallus gallus, Escherichia coli, Neurospora crassa, Sus scrofa, Tetrahymena pyriformis
brenda
Deana, R.; Fabbro, M.; Rigoni, F.
Formation and utilization of 3-hydroxy-3-methylglutarate in liver mitochondria of starved and streptozotocin-diabetic rats
Biochem. J.
172
371-375
1978
Rattus norvegicus
brenda
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