Reference on EC 3.1.2.22 - palmitoyl[protein] hydrolase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Cho, S.; Dawson, G.
Enzymatic and molecular biological analysis of palmitoyl protein thioesterase deficiency in infantile neuronal ceroid lipofuscinosis
J. Neurochem.
71
323-329
1998
Homo sapiens
Hellsten, E.; Vesa, J.; Olkkonen, V.M.; Jalanko, A.; Peltonen, L.
Human palmitoyl protein thioesterase: evidence for lysosomal targeting of the enzyme and disturbed cellular routing in infantile neuronal ceroid lipofuscinosis
EMBO J.
15
5240-5245
1996
Homo sapiens
Vesa, J.; Hellsten, E.; Verkruyse, L.A.; Camp, L.A.; Rapola, J.; Santavuori, P.; Hofmann, S.L.; Peltonen, L.
Mutations in the palmitoyl protein thioesterase gene causing infantile neuronal ceroid lipofuscinosis
Nature
376
584-587
1995
Homo sapiens
Schriner, J.E.; Yi, W.; Hofmann, S.L.
cDNA and genomic cloning of human palmitoyl-protein thioesterase (PPT), the enzyme defective in infantile neuronal ceroid lipofuscinosis
Genomics
34
317-4322
1996
Homo sapiens (P50897), Homo sapiens
Verkruyse, L.A.; Hofmann, S.L.
Lysosomal targeting of palmitoyl-protein thioesterase
J. Biol. Chem.
271
15831-15836
1996
Homo sapiens
Camp, L.A.; Hofmann, S.L.
Assay and isolation of palmitoyl-protein thioesterase from bovine brain using palmitoylated H-Ras as substrate
Methods Enzymol.
250
336-347
1995
Bos taurus
Camp, L.A.; Hofmann, S.L.
Purification and properties of a palmitoyl-protein thioesterase that cleaves palmitate from H-Ras
J. Biol. Chem.
268
22566-22574
1993
Bos taurus
Slea, D.E.; Sohar, I.; Lackland, H.; Majercak, J.; Lobel, P.
Rat brain contains high levels of mannose-6-phosphorylated glycoproteins including enzymes and palmitoyl-protein thioesterase, an enzyme implicated in infantile neuronal lipofuscinosis
J. Biol. Chem.
271
19191-19198
1996
Rattus norvegicus
Lu, J.Y.; Verkruyse, L.A.; Hofmann, S.L.
Lipid thioesters derived from acylated proteins accumulate in infantile neuronal ceroid lipofuscinosis: correction of the defect in lymphoblasts by recombinant palmitoyl-protein thioesterase
Proc. Natl. Acad. Sci. USA
93
10046-10050
1996
Homo sapiens
Michel, J.B.; Michel, T.
The role of palmitoyl-protein thioesterase in the palmitoylation of endothelial nitric oxide synthetase
FEBS Lett.
405
356-362
1997
Bos taurus
Meng, L.; Sin, N.; Crews, C.M.
The antiproliferative agent didemnin B uncompetitively inhibits palmitoyl protein thioesterase
Biochemistry
37
10488-10492
1998
Homo sapiens
Lu, J.Y.; Verkruyse, L.A.; Hofmann, S.L.
The effects of lysosomotropic agents on normal and INCL cells provide further evidence for the lysosomal nature of palmitoyl-protein thioesterase function
Biochim. Biophys. Acta
1583
35-44
2002
Homo sapiens
Lukacs, Z.; Santavuori, P.; Keil, A.; Steinfeld, R.; Kohlschutter, A.
Rapid and simple assay for the determination of tripeptidyl peptidase and palmitoyl protein thioesterase activities in dried blood spots
Clin. Chem.
49
509-512
2003
Homo sapiens
Cho, S.K.; Hofmann, S.L.
pdf1, a palmitoyl protein thioesterase 1 ortholog in Schizosaccharomyces pombe: a yeast model of infantile Batten disease
Eukaryot. Cell
3
302-310
2004
Schizosaccharomyces pombe (O59747), Schizosaccharomyces pombe
Das, A.K.; Lu, J.Y.; Hofmann, S.L.
Biochemical analysis of mutations in palmitoyl-protein thioesterase causing infantile and late-onset forms of neuronal ceroid lipofuscinosis
Hum. Mol. Genet.
10
1431-1439
2001
Homo sapiens
Lehtovirta, M.; Kyttala, A.; Eskelinen, E.L.; Hess, M.; Heinonen, O.; Jalanko, A.
Palmitoyl protein thioesterase (PPT) localizes into synaptosomes and synaptic vesicles in neurons: implications for infantile neuronal ceroid lipofuscinosis (INCL)
Hum. Mol. Genet.
10
69-75
2001
Homo sapiens, Mus musculus
Waliany, S.; Das, A.K.; Gaben, A.; Wisniewski, K.E.; Hofmann, S.L.
Identification of three novel mutations of the palmitoyl-protein thioesterase-1 (PPT1) gene in children with neuronal ceroid-lipofuscinosis
Hum. Mutat.
15
206-207
2000
Homo sapiens
Salonen, T.; Jarvela, I.; Peltonen, L.; Jalanko, A.
Detection of eight novel palmitoyl protein thioesterase (PPT) mutations underlying infantile neuronal ceroid lipofuscinosis (INCL;CLN1)
Hum. Mutat.
15
273-279
2000
Homo sapiens
Calero, G.; Gupta, P.; Nonato, M.C.; Tandel, S.; Biehl, E.R.; Hofmann, S.L.; Clardy, J.
The crystal structure of palmitoyl protein thioesterase-2 (PPT2) reveals the basis for divergent substrate specificities of the two lysosomal thioesterases, PPT1 and PPT2
J. Biol. Chem.
278
37957-37964
2003
Homo sapiens
Ahtiainen, L.; Van Diggelen, O.P.; Jalanko, A.; Kopra, O.
Palmitoyl protein thioesterase 1 is targeted to the axons in neurons
J. Comp. Neurol.
455
368-377
2003
Mus musculus
Salonen, T.; Heinonen-Kopra, O.; Vesa, J.; Jalanko, A.
Neuronal trafficking of palmitoyl protein thioesterase provides an excellent model to study the effects of different mutations which cause infantile neuronal ceroid lipofuscinocis
Mol. Cell. Neurosci.
18
131-140
2001
Homo sapiens
Suopanki, J.; Tyynela, J.; Baumann, M.; Haltia, M.
The expression of palmitoyl-protein thioesterase is developmentally regulated in neural tissues but not in nonneural tissues
Mol. Genet. Metab.
66
290-293
1999
Rattus norvegicus
Suopanki, J.; Lintunen, M.; Lahtinen, H.; Haltia, M.; Panula, P.; Baumann, M.; Tyynela, J.
Status epilepticus induces changes in the expression and localization of endogenous palmitoyl-protein thioesterase 1
Neurobiol. Dis.
10
247-257
2002
Rattus norvegicus
Suopanki, J.; Tyynela, J.; Baumann, M.; Haltia, M.
Palmitoyl-protein thioesterase, an enzyme implicated in neurodegeneration, is localized in neurons and is developmentally regulated in rat brain
Neurosci. Lett.
265
53-56
1999
Rattus norvegicus
Bellizzi, J.J., 3rd; Widom, J.; Kemp, C.; Lu, J.Y.; Das, A.K.; Hofmann, S.L.; Clardy, J.
The crystal structure of palmitoyl protein thioesterase 1 and the molecular basis of infantile neuronal ceroid lipofuscinosis
Proc. Natl. Acad. Sci. USA
97
4573-4578
2000
Homo sapiens
Kohan, R.; Noher de Halac, I.; Anzolini, V.T.; Cismondi, A.; Oller Ramirez, A.M.; Capra, A.P.; Dodelson de Kremer, R.
Palmitoyl protein thioesterase 1 (PPT1) and tripeptidyl peptidase-I (TPP-I) are expressed in the human saliva. A reliable and non-invasive source for the diagnosis of infantile (CLN1) and late infantile (CLN2) neuronal ceroid lipofuscinoses
Clin. Biochem.
38
492-494
2005
Homo sapiens
Zhang, Z.; Lee, Y.C.; Kim, S.J.; Choi, M.S.; Tsai, P.C.; Xu, Y.; Xiao, Y.J.; Zhang, P.; Heffer, A.; Mukherjee, A.B.
Palmitoyl-protein thioesterase-1 deficiency mediates the activation of the unfolded protein response and neuronal apoptosis in INCL
Hum. Mol. Genet.
15
337-346
2005
Mus musculus
Porter, M.Y.; Turmaine, M.; Mole, S.E.
Identification and characterization of Caenorhabditis elegans palmitoyl protein thioesterase 1
J. Neurosci. Res.
79
836-848
2005
Caenorhabditis elegans
Lyly, A.; von Schantz, C.; Salonen, T.; Kopra, O.; Saarela, J.; Jauhiainen, M.; Kyttaelae, A.; Jalanko, A.
Glycosylation, transport, and complex formation of palmitoyl protein thioesterase 1 (PPT1) - distinct characteristics in neurons
BMC Cell Biol.
8
22
2007
Homo sapiens (P50897)
Buff, H.; Smith, A.C.; Korey, C.A.
Genetic modifiers of Drosophila palmitoyl-protein thioesterase 1-induced degeneration
Genetics
176
209-220
2007
Drosophila sp. (in: flies)
Bannan, B.A.; Van Etten, J.; Kohler, J.A.; Tsoi, Y.; Hansen, N.M.; Sigmon, S.; Fowler, E.; Buff, H.; Williams, T.S.; Ault, J.G.; Glaser, R.L.; Korey, C.A.
The Drosophila protein palmitoylome: Characterizing palmitoyl-thioesterases and DHHC palmitoyl-transferases
Fly
2
198-214
2008
Drosophila melanogaster
Kim, S.J.; Zhang, Z.; Sarkar, C.; Tsai, P.C.; Lee, Y.C.; Dye, L.; Mukherjee, A.B.
Palmitoyl protein thioesterase-1 deficiency impairs synaptic vesicle recycling at nerve terminals, contributing to neuropathology in humans and mice
J. Clin. Invest.
118
3075-3086
2008
Homo sapiens, Mus musculus
Hirano, T.; Kishi, M.; Sugimoto, H.; Taguchi, R.; Obinata, H.; Ohshima, N.; Tatei, K.; Izumi, T.
Thioesterase activity and subcellular localization of acylprotein thioesterase 1/lysophospholipase 1
Biochim. Biophys. Acta
1791
797-805
2009
Homo sapiens (O75608), Homo sapiens
Tardy, C.; Sabourdy, F.; Garcia, V.; Jalanko, A.; Therville, N.; Levade, T.; Andrieu-Abadie, N.
Palmitoyl protein thioesterase 1 modulates tumor necrosis factor alpha-induced apoptosis
Biochim. Biophys. Acta
1793
1250-1258
2009
Mus musculus, Homo sapiens (P50897), Homo sapiens
Takano, K.; Shimono, M.; Shiota, N.; Kato, A.; Tomioka, S.; Oka, A.; Ohno, K.; Sathou, H.
Infantile neuronal ceroid lipofuscinosis: The first reported case in Japan diagnosed by palmitoyl-protein thioesterase enzyme activity deficiency
Brain Dev.
30
370-373
2008
Homo sapiens
Macauley, S.L.; Wozniak, D.F.; Kielar, C.; Tan, Y.; Cooper, J.D.; Sands, M.S.
Cerebellar pathology and motor deficits in the palmitoyl protein thioesterase 1-deficient mouse
Exp. Neurol.
217
124-135
2009
Mus musculus
Lu, J.Y.; Hu, J.; Hofmann, S.L.
Human recombinant palmitoyl-protein thioesterase-1 (PPT1) for preclinical evaluation of enzyme replacement therapy for infantile neuronal ceroid lipofuscinosis
Mol. Genet. Metab.
99
374-378
2010
Homo sapiens
Saja, S.; Buff, H.; Smith, A.C.; Williams, T.S.; Korey, C.A.
Identifying cellular pathways modulated by Drosophila palmitoyl-protein thioesterase 1 function
Neurobiol. Dis.
40
135-145
2010
Drosophila melanogaster, Drosophila sp. (in: flies)
Sanders, D.N.; Farias, F.H.; Johnson, G.S.; Chiang, V.; Cook, J.R.; OBrien, D.P.; Hofmann, S.L.; Lu, J.Y.; Katz, M.L.
A mutation in canine PPT1 causes early onset neuronal ceroid lipofuscinosis in a Dachshund
Mol. Genet. Metab.
100
349-356
2010
Canis lupus familiaris (Q5JZR0), Canis lupus familiaris
Chu-LaGraff, Q.; Blanchette, C.; OHern, P.; Denefrio, C.
The Batten disease Palmitoyl Protein Thioesterase 1 gene regulates neural specification and axon connectivity during Drosophila embryonic development
PLoS ONE
5
e14402
2010
Drosophila melanogaster
Aby, E.; Gumps, K.; Roth, A.; Sigmon, S.; Jenkins, S.E.; Kim, J.J.; Kramer, N.J.; Parfitt, K.D.; Korey, C.A.
Mutations in palmitoyl-protein thioesterase 1 alter exocytosis and endocytosis at synapses in Drosophila larvae
Fly
7
267-279
2014
Drosophila melanogaster (Q9W3C7), Drosophila melanogaster
Hu, J.; Lu, J.Y.; Wong, A.M.; Hynan, L.S.; Birnbaum, S.G.; Yilmaz, D.S.; Streit, B.M.; Lenartowicz, E.M.; Thompson, T.C.; Cooper, J.D.; Hofmann, S.L.
Intravenous high-dose enzyme replacement therapy with recombinant palmitoyl-protein thioesterase reduces visceral lysosomal storage and modestly prolongs survival in a preclinical mouse model of infantile neuronal ceroid lipofuscinosis
Mol. Genet. Metab.
107
213-221
2012
Mus musculus
Liu, Y.; Zhao, W.; Gu, G.; Lu, L.; Feng, J.; Guo, Q.; Ding, Z.
Palmitoyl-protein thioesterase 1 (PPT1): an obesity-induced rat testicular marker of reduced fertility
Mol. Reprod. Dev.
81
55-65
2014
Rattus norvegicus (P45479)
Spinelli, M.; Fusco, S.; Grassi, C.
Nutrient-dependent changes of protein palmitoylation Impact on nuclear enzymes and regulation of gene expression
Int. J. Mol. Sci.
19
E3820
2018
Homo sapiens
-
Scifo, E.; Szwajda, A.; Soliymani, R.; Pezzini, F.; Bianchi, M.; Dapkunas, A.; Debski, J.; Uusi-Rauva, K.; Dadlez, M.; Gingras, A.C.; Tyynelae, J.; Simonati, A.; Jalanko, A.; Baumann, M.H.; Lalowski, M.
Proteomic analysis of the palmitoyl protein thioesterase 1 interactome in SH-SY5Y human neuroblastoma cells
J. Proteomics
123
42-53
2015
Homo sapiens (P50897), Homo sapiens
Shyng, C.; Macauley, S.L.; Dearborn, J.T.; Sands, M.S.
Widespread expression of a membrane-tethered version of the soluble lysosomal enzyme palmitoyl protein thioesterase-1
JIMD Rep.
36
85-92
2017
Homo sapiens
Meyer, M.; Kovacs, A.D.; Pearce, D.A.
Decreased sensitivity of palmitoyl protein thioesterase 1-deficient neurons to chemical anoxia
Metab. Brain Dis.
32
275-279
2017
Mus musculus (Q88531)
Dearborn, J.T.; Ramachandran, S.; Shyng, C.; Lu, J.Y.; Thornton, J.; Hofmann, S.L.; Sands, M.S.
Histochemical localization of palmitoyl protein thioesterase-1 activity
Mol. Genet. Metab.
117
210-216
2016
Mus musculus
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