Information on EC 3.1.2.15 - ubiquitin thiolesterase

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The expected taxonomic range for this enzyme is: Oryctolagus cuniculus

EC NUMBER
COMMENTARY
3.1.2.15
-
RECOMMENDED NAME
GeneOntology No.
ubiquitin thiolesterase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
hydrolysis of thioester
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ubiquitin-C-terminal-thioester hydrolase
Acts on esters formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin. Also acts on AMP-ubiquitin. May be the same as EC 3.4.19.12, ubiquitinyl hydrolase 1.
CAS REGISTRY NUMBER
COMMENTARY
86480-67-3
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ubiquitin-AMP + H2O
ubiquitin + AMP
show the reaction diagram
-
-
-
-
?
ubiquitin-dithiothreitol thiolester + H2O
ubiquitin + dithiothreitol
show the reaction diagram
-
thiolester between ubiquitin carboxyl terminus and dithiothreitol
-
?
ubiquitin-glutathione thiolester + H2O
ubiquitin + glutathione
show the reaction diagram
-
thiolester between ubiquitin carboxyl terminus and glutathione
-
-
?
INHIBITORS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
iodoacetamide
-
ubiquitin protects
ubiquitin
-
product inhibition
SPECIFIC ACTIVITY [µmol/min/mg]
SPECIFIC ACTIVITY MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
additional information
-
-
-
pH OPTIMUM
pH MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
7.6
-
-
assay at
TEMPERATURE OPTIMUM
TEMPERATURE OPTIMUM MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
37
-
-
assay at
SOURCE TISSUE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
SOURCE
MOLECULAR WEIGHT
MOLECULAR WEIGHT MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
30000
-
-
gel filtration
Purification/COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE