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Information on EC 3.1.13.4 - poly(A)-specific ribonuclease and Organism(s) Drosophila melanogaster

for references in articles please use BRENDA:EC3.1.13.4
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This record set is specific for:
Drosophila melanogaster
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The taxonomic range for the selected organisms is: Drosophila melanogaster
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Reaction Schemes
exonucleolytic cleavage of poly(A) to 5'-AMP
Synonyms
deadenylase, ccr4-not complex, parn, poly(a)-specific ribonuclease, rnase as, pnldc1, cytoplasmic deadenylase, poly(a) nuclease, 3'-exoribonuclease, ccr4-associated factor 1, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
2',3'-exoribonuclease
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-
-
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3'-exoribonuclease
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-
-
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CCR4 deadenylase complex
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nuclease, polyadenylate-specific exoribo-
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-
-
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PAB1P-dependent poly(A)-nuclease
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-
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poly(A)-specific 3'-exoribonuclease
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-
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poly(A)-specific mRNA exoribonuclease
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-
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-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of phosphoric ester
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-
-
-
CAS REGISTRY NUMBER
COMMENTARY hide
110541-21-4
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215797-47-0
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
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Bic-C activates CCR4-dependent deadenylation of specific mRNAs during early oogenesis. Bic-C binds specific segments of the Bic-C 50 untranslated region and negatively regulates its own expression by binding directly to NOT3/5, a component of the CCR4 core deadenylase complex. CCR4-HA and NOT3/5 form an RNase-resistant complex with Bic-C
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
PAN2_DROME
1241
0
138968
Swiss-Prot
other Location (Reliability: 1)
Q8IMX0_DROME
358
0
41006
TrEMBL
other Location (Reliability: 2)
Q8I0I5_DROME
293
0
33479
TrEMBL
other Location (Reliability: 1)
Q7K126_DROME
844
0
92368
TrEMBL
other Location (Reliability: 2)
E2QCN4_DROME
2492
0
279869
TrEMBL
other Location (Reliability: 3)
A0A0B4LEY4_DROME
1240
0
138880
TrEMBL
other Location (Reliability: 1)
A8DY81_DROME
2505
0
281141
TrEMBL
other Location (Reliability: 3)
A0A6M3Q6V5_DROME
341
0
38708
TrEMBL
other Location (Reliability: 3)
X2JCC3_DROME
361
0
40745
TrEMBL
other Location (Reliability: 3)
Q9VTS4_DROME
297
0
34025
TrEMBL
other Location (Reliability: 3)
A8DY80_DROME
2503
0
280886
TrEMBL
other Location (Reliability: 3)
A8DY82_DROME
2220
0
249761
TrEMBL
other Location (Reliability: 4)
A0A0B4LEZ3_DROME
2511
0
281682
TrEMBL
Secretory Pathway (Reliability: 5)
Q7K112_DROME
552
0
63242
TrEMBL
other Location (Reliability: 2)
Q8IGD6_DROME
293
0
33478
TrEMBL
other Location (Reliability: 1)
Q8IMX1_DROME
567
0
65047
TrEMBL
other Location (Reliability: 2)
E1JHY7_DROME
357
0
40198
TrEMBL
other Location (Reliability: 1)
A0A0B4LHS9_DROME
579
0
59271
TrEMBL
Mitochondrion (Reliability: 3)
Q9VCB6_DROME
545
0
62383
TrEMBL
other Location (Reliability: 3)
Q8MR41_DROME
271
0
30211
TrEMBL
other Location (Reliability: 1)
Q8MTZ5_DROME
566
0
64808
TrEMBL
other Location (Reliability: 2)
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Chicoine, J.; Benoit, P.; Gamberi, C.; Paliouras, M.; Simonelig, M.; Lasko, P.
Bicaudal-C recruits CCR4-NOT deadenylase to target mRNAs and regulates oogenesis, cytoskeletal organization, and its own expression
Dev. Cell
13
691-704
2007
Drosophila melanogaster
Manually annotated by BRENDA team