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Information on EC 3.1.1.98 - [Wnt protein] O-palmitoleoyl-L-serine hydrolase and Organism(s) Danio rerio

for references in articles please use BRENDA:EC3.1.1.98
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EC Tree
IUBMB Comments
The enzyme removes the palmitoleate modification that is introduced to specific L-serine residues in Wnt proteins by EC 2.3.1.250, [Wnt protein]-O-palmitoleoyl transferase.
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This record set is specific for:
Danio rerio
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Word Map
The taxonomic range for the selected organisms is: Danio rerio
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
[Wnt]-O-(9Z)-hexadec-9-enoyl-L-serine
+
=
[Wnt]-L-serine
+
Synonyms
notum, notum 1a, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Notum
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
[Wnt]-O-(9Z)-hexadec-9-enoyl-L-serine acylhydrolase
The enzyme removes the palmitoleate modification that is introduced to specific L-serine residues in Wnt proteins by EC 2.3.1.250, [Wnt protein]-O-palmitoleoyl transferase.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
expression of Notum1a first appears around the blastoderm margin prior to the onset of gastrulation
Manually annotated by BRENDA team
at 24 h post fertilization, expression is particularly pronounced in the central nervous system, including the dorsal neural tube and the midbrain-hindbrain boundary
Manually annotated by BRENDA team
Notum1a is expressed in the lateral edges and midline of the posterior neural plate. During segmentation, it is expressed in stripes at the lateral edges and adjacent to the midline of the neural plate
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
Notum1a contributes to a self-regulatory loop that restricts Wnt/betA-catenin signaling. Notum 1a does not interact with Glypican 4, an essential component of the Wnt/planar cell polarity pathway, but plays specific role in the developing vertebrate embryo. In cultured cells, Notum1a inhibits Wnt/beta-catenin signaling
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
NOT1A_DANRE
500
1
56715
Swiss-Prot
Secretory Pathway (Reliability: 2)
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
Notum1a expression requires Wnt/beta-catenin signaling
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Flowers, G.P.; Topczewska, J.M.; Topczewski, J.
A zebrafish Notum homolog specifically blocks the Wnt/beta-catenin signaling pathway
Development
139
2416-2425
2012
Danio rerio (C5H5C4), Danio rerio
Manually annotated by BRENDA team