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EC Tree
The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
diphthine methyl ester-[translation elongation factor 2]
+
=
diphthine-[translation elongation factor 2]
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Synonyms
wdr85, ybr246w,
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Dph7
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diphthine methyl ester acylhydrolase
The protein is only present in eukaryotes.
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diphthine methyl ester-[translation elongation factor 2] + H2O
diphthine-[translation elongation factor 2] + methanol
diphthine methyl ester-[translation elongation factor 2] + H2O
diphthine-[translation elongation factor 2] + methanol
the enzyme is involved in diphthamide biosynthesis pathway
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-
?
diphthine methyl ester-[translation elongation factor 2] + H2O
diphthine-[translation elongation factor 2] + methanol
diphthine methyl ester i.e. 2-[(3S)-3-carboxy methyl ester-3-(trimethylammonio)propyl]-L-histidine
diphthine i.e. 2-[(3S)-3-carboxy-3-(trimethylammonio)propyl]-L-histidine
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?
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diphthine methyl ester-[translation elongation factor 2] + H2O
diphthine-[translation elongation factor 2] + methanol
the enzyme is involved in diphthamide biosynthesis pathway
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-
?
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Lymphoma
A Modified Form of Diphthamide Causes Immunotoxin Resistance in a Lymphoma Cell Line with Deletion of WDR85.
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SwissProt
brenda
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metabolism
the enzyme is involved in diphthamide biosynthesis pathway
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DPH7_HUMAN
452
0
50575
Swiss-Prot
other Location (Reliability: 3)
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Lin, Z.; Su, X.; Chen, W.; Ci, B.; Zhang, S.; Lin, H.
Dph7 catalyzes a previously unknown demethylation step in diphthamide biosynthesis
J. Am. Chem. Soc.
136
6179-6182
2014
Homo sapiens (Q9BTV6), Homo sapiens, Saccharomyces cerevisiae (P38332), Saccharomyces cerevisiae ATCC 204508 (P38332)
brenda
3.1.1.97 methylated diphthine methylhydrolase
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The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). 
