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IUBMB CommentsActs on a number of benzyl esters of substituted phenyl propanoates, and on the benzyl esters of phenylalanine and tyrosine.
The expected taxonomic range for this enzyme is: Aspergillus niger
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cetraxate benzyl ester + H2O = cetraxate + benzyl alcohol
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hydrolysis of carboxylic ester
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cetraxate-benzyl-ester benzylhydrolase
Acts on a number of benzyl esters of substituted phenyl propanoates, and on the benzyl esters of phenylalanine and tyrosine.
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benzyl esters of substituted phenyl propanoates + H2O
benzyl alcohol + substituted phenyl propanoate
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benzyl esters of aliphatic and aromatic carboxylic acids, benzyl esters of phenylalanine Phe-By and tyrosine Tyr-By are hydrolyzed
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cetraxate benzyl ester + H2O
cetraxate + benzyl alcohol
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L-Phe benzyl ester + H2O
benzyl alcohol + L-phenylalanine
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L-Tyr benzyl ester + H2O
benzyl alcohol + L-tyrosine
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additional information
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enzyme shows no cellulase, protease or lipase activity, does not hydrolyze ester groups such as Tyr-Me, Tyr-tert-Bu, 1-Me, 1-iso-Pro and 1 Ph
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cetraxate benzyl ester + H2O
cetraxate + benzyl alcohol
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L-Phe benzyl ester + H2O
benzyl alcohol + L-phenylalanine
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L-Tyr benzyl ester + H2O
benzyl alcohol + L-tyrosine
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Ca2+
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1.0 mM, 71% relative residual activity
Co2+
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1.0 mM, 68% relative residual activity
Cu2+
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1.0 mM, 72% relative residual activity
diisopropyl phosphofluoridate
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9% relative residual activity
Fe2+
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1.0 mM, 81% relative residual activity
Hg2+
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9% relative residual activity
Mg2+
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1.0 mM, 64% relative residual activity
Mn2+
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1.0 mM, 79% relative residual activity
Ni2+
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1.0 mM, 67% relative residual activity
o-phenanthroline
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80% relative residual activity
Zn2+
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1.0 mM, 70% relative residual activity
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4
benzyl cetraxate
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pH 4.5, 30°C
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additional information
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specific activity 791 units/mg
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4.5
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for debenzylating substrate
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5.3
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isoelectric focusing, carrier ampholite, pH range from 3.5-10.0 at 200 V for 30 min and 700 V for 90 min
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brenda
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Sumizyme AC, Shin-Nippon Chemical Industries Co., Ltd., cellulase activity 2-5 unit/mg
brenda
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monomer
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1 * 35000, SDS-PAGE
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4 - 7
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stable in this range
643849
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40
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stable at temperatures below
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medicine
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cetraxate hydrochloride is a widely used antiulcer agent industrially produced
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Kuroda, H.; Miyadera, A.; Imura, A.; Suzuki, A.
Partial purification, and some properties and reactivities of cetraxate benzyl ester hydrochloride-hydrolyzing enzyme
Chem. Pharm. Bull.
37
2929-2932
1989
Aspergillus niger
brenda
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