Information on EC 3.1.1.7 - acetylcholinesterase

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The expected taxonomic range for this enzyme is: Eukaryota

EC NUMBER
COMMENTARY
3.1.1.7
-
RECOMMENDED NAME
GeneOntology No.
acetylcholinesterase
-
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
acetylcholine + H2O = choline + acetate
show the reaction diagram
-
-
-
-
acetylcholine + H2O = choline + acetate
show the reaction diagram
mechanism
-
acetylcholine + H2O = choline + acetate
show the reaction diagram
mechanism
-
acetylcholine + H2O = choline + acetate
show the reaction diagram
mathematical modelling of mechanism
-
acetylcholine + H2O = choline + acetate
show the reaction diagram
computer-modelled comparison of ordered uni bi and ki kinetic mechanism. ki model is accurate at equilibrium and when the inhibitor concentration is well below its Kd value
-
acetylcholine + H2O = choline + acetate
show the reaction diagram
formation of the trigonal bipyramidal transition state
-
acetylcholine + H2O = choline + acetate
show the reaction diagram
reaction mechanism, structure-function relationship analysis, binding structure and mechanism of substrate and product at both the peripheral and active sites, overview
-
acetylcholine + H2O = choline + acetate
show the reaction diagram
reaction mechanism, active site structure, the catalytic triad comprises the residues Ser203, His447, Glu334, residues Ser203 and His447 are directly involved in the reaction, serving as nucleophilic attacking group and general acid base catalytic elements, respectively, at the acylation stage of the enzymatic reaction. Modern molecular modeling using tools including molecular docking, molecular dynamics (MD), quantum chemistry and the combined quantum mechanical-molecular mechanical method, overview
-
acetylcholine + H2O = choline + acetate
show the reaction diagram
the mechanism for AChE-catalyzed hydrolysis of substrate is formation of the first tetrahedral intermediate via nucleophilic attack of the active site serine
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of carboxylic ester
-
-
-
-
transacetylation
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Glycerophospholipid metabolism
-
-
SYSTEMATIC NAME
IUBMB Comments
acetylcholine acetylhydrolase
Acts on a variety of acetic esters; also catalyses transacetylations.
SYNONYMS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
AcCholE
-
-
-
-
ACE-1
-
gene name
ace2-type acetylcholinesterase
-
acetyl beta-methylcholinesterase
-
-
-
-
acetyl cholinesterase
-
-
acetylcholine acetylhydrolase
-
-
acetylcholine esterase
-
-
-
-
acetylcholine hydrolase
-
-
-
-
acetylcholinesterase
-
-
acetylcholinesterase
-
-
acetylcholinesterase
-
-
acetylcholinesterase
-
-
acetylcholinesterase 1
-
-
acetylcholinesterase 1
-
-
acetylcholinesterase 2
-
-
acetylcholinesterase-1
-
-
acetylthiocholinesterase
-
-
-
-
AChE
-
-
-
-
AChE
-
-
AChE
Cimex lectularius Bedbug
-
-
-
AChE
Hydra magnipapillata 105
-
-
-
AChE
-
-
AChE1
-
isoform
AChE1
-
isoform
AChE2
-
isoform
AChE2
-
isoform
choline esterase I
-
-
-
-
cholinesterase
-
-
-
-
cholinesterase
-
-
cholinesterase
-
-
cholinesterase 2
-
-
esterase, acetyl choline
-
-
-
-
true cholinesterase
-
-
-
-
type VI-S AChE
-
-
membrane-bound acetylcholinesterase
-
-
additional information
-
cf. EC 3.1.1.8
additional information
-
the enzyme belongs to the superfamily of alpha/beta-hydrolase fold proteins
CAS REGISTRY NUMBER
COMMENTARY
9000-81-1
-
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
yellow fever mosquito
-
-
Manually annotated by BRENDA team
razorbill
-
-
Manually annotated by BRENDA team
Malaria mosquito
-
-
Manually annotated by BRENDA team
cotton aphid
-
-
Manually annotated by BRENDA team
German cockroach
-
-
Manually annotated by BRENDA team
immobilised on a Langmuir-Blodgett proteo-glycolipidic bilayer
-
-
Manually annotated by BRENDA team
male and female Hartley guinea pigs
-
-
Manually annotated by BRENDA team
peacock bass
-
-
Manually annotated by BRENDA team
Cimex lectularius Bedbug
Bedbug
-
-
Manually annotated by BRENDA team
carboxylesterase 1 fragment
UniProt
Manually annotated by BRENDA team
carboxylesterase 2 fragment
UniProt
Manually annotated by BRENDA team
carboxylesterase 3 fragment
UniProt
Manually annotated by BRENDA team
Hong Kong oyster
-
-
Manually annotated by BRENDA team
Nothern house mosquito
-
-
Manually annotated by BRENDA team
recombinant enzyme, wild-type and truncated mutants
-
-
Manually annotated by BRENDA team
Drosophila melanogaster MH19
strain MH19
-
-
Manually annotated by BRENDA team
type VI-S enzyme
-
-
Manually annotated by BRENDA team
cotton aphid
-
-
Manually annotated by BRENDA team
Atlantic puffin
-
-
Manually annotated by BRENDA team
blood-sucking stomach worm of domestic animals
-
-
Manually annotated by BRENDA team
multi-colored Asian ladybird beetle
-
-
Manually annotated by BRENDA team
eight different Egyptian strains EA2, EB6, EB7, EG7, EG8, EG9, EK1 and EK2, different isozymes, i.e. AChE1A, isozyme pattern
-
-
Manually annotated by BRENDA team
commercial preparation
-
-
Manually annotated by BRENDA team
R-isoform, expression in Nicotiana benthamiana, or commercial preparation
-
-
Manually annotated by BRENDA team
recombinant protein
-
-
Manually annotated by BRENDA team
vitiligo patients with almost absent acetylcholinesterase
-
-
Manually annotated by BRENDA team
strain 105
-
-
Manually annotated by BRENDA team
Hydra magnipapillata 105
strain 105
-
-
Manually annotated by BRENDA team
populations from Sichuan Province, Hubei Province and Chongqing Municipality
-
-
Manually annotated by BRENDA team
collected from Huanghua and Pingshan County
-
-
Manually annotated by BRENDA team
Australian sheep blowfly
UniProt
Manually annotated by BRENDA team
sea urchins collected from St. Joseph Bay, Florida in May of 2006
-
-
Manually annotated by BRENDA team
exon 2; rhesus macaque; exon 3; rhesus macaque; exon 4; rhesus macaque; exon 6; rhesus macaque
UniProt
Manually annotated by BRENDA team
exon 5; rhesus macaque
SwissProt
Manually annotated by BRENDA team
isoforms G1 and G4
-
-
Manually annotated by BRENDA team
male Balb-c mice
-
-
Manually annotated by BRENDA team
male BALB/c mice, C57BL/6 mice with a7nAChR deficiency and wild-type littermates
-
-
Manually annotated by BRENDA team
male C57BL6/J mice
-
-
Manually annotated by BRENDA team
male ICR mice
-
-
Manually annotated by BRENDA team
recombinant enzyme
-
-
Manually annotated by BRENDA team
Swiss adult male mice
-
-
Manually annotated by BRENDA team
treated with scopolamine
-
-
Manually annotated by BRENDA team
3 forms monomer/dimer/tetramer
-
-
Manually annotated by BRENDA team
house-fly, 5 forms
-
-
Manually annotated by BRENDA team
housefly, variants insensitive to organophosphate and carbmate insecticides
SwissProt
Manually annotated by BRENDA team
mussel
-
-
Manually annotated by BRENDA team
Nephotettix cincticeps Uhler
strains susceptible and resistant to carbamate and organophosphorus insecticides
-
-
Manually annotated by BRENDA team
albino rabbit
-
-
Manually annotated by BRENDA team
American cockroach
-
-
Manually annotated by BRENDA team
male Albino Charles Foster rats
-
-
Manually annotated by BRENDA team
male Wistar
-
-
Manually annotated by BRENDA team
whole-body hypothermia increases the degree of substrate inhibition of enzyme, its maximum rate and its Km-value
-
-
Manually annotated by BRENDA team
Wistar rats
-
-
Manually annotated by BRENDA team
several molecular forms
-
-
Manually annotated by BRENDA team
greenbug aphid
-
-
Manually annotated by BRENDA team
White Landrace pig and Goettingen minipig
-
-
Manually annotated by BRENDA team
isozyme ChE2
UniProt
Manually annotated by BRENDA team
type VI-S AChE
UniProt
Manually annotated by BRENDA team
flour beetle
-
-
Manually annotated by BRENDA team
common guillemot
-
-
Manually annotated by BRENDA team
desert cobra
-
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
physiological function
-
hydrolysis of acetylcholine by acetylcholinesterase is a key process for the regulation of the neutral response system
physiological function
-
AChE is a pivotal enzyme in the cholinergic nervous system. Its primary function is to catalyze hydrolysis of released acetylcholine and thus maintain homeostasis of this neurotransmitter in the central and peripheral nervous systems
physiological function
-
isoform AChE1 plays a major role in postsynaptic transmission
physiological function
-
isoform AChE2 is responsible for synaptic transmission. Isoform AChE1 plays a protective role against xenobiotics
malfunction
-
Alzheimer's disease, a neurodegenerative disease characterized by a low concentration of acetylcholine in the hippocampus and cortex, is the leading cause of dementia among older people
additional information
-
regeneration is controlled by the non-neuronal cholinergic system in Hydra
additional information
Hydra magnipapillata 105
-
regeneration is controlled by the non-neuronal cholinergic system in Hydra
-
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2,6-dichloro-3'-methylindophenylacetate + H2O
2,6-dichloro-3'-methylindophenol + acetate
show the reaction diagram
-
-
-
?
2,6-dichloro-3'-methylindophenylacetate + H2O
2,6-dichloro-3'-methylindophenol + acetate
show the reaction diagram
-
weak substrate
-
?
2,6-dichlorophenolindophenylacetate + H2O
2,6-dichlorophenolindophenol + acetate
show the reaction diagram
-
-
-
?
2-methoxyacetylthiocholine + H2O
thiocholine + 2-methoxyacetate
show the reaction diagram
-
recombinant enzyme shows about 12% activity compared to acetylthiocholine
-
?
2-methoxyacetylthiocholine + H2O
thiocholine + 2-methoxyacetate
show the reaction diagram
recombinant enzyme shows about 65% activity compared to acetylthiocholine
-
?
3',5'-dichloro-2'-methylindophenylacetate + H2O
3',5'-dichloro-2'-methylindophenol + acetate
show the reaction diagram
-
weak substrate
-
?
3',5'-dichlorophenolindophenylacetate + H2O
3',5'-dichlorophenolindophenol + acetate
show the reaction diagram
-
weak substrate
-
?
3-(acetamido)-N,N,N-trimethylanilinium + H2O
?
show the reaction diagram
-
slow hydrolysis
-
-
?
3-(acetamido)-N,N,N-trimethylanilinum + H2O
?
show the reaction diagram
-
ATMA
-
-
?
3-methylbutyrylthiocholine + H2O
thiocholine + 3-methylbutyrate
show the reaction diagram
-
recombinant enzyme shows about 1% activity compared to acetylthiocholine
-
?
3-methylbutyrylthiocholine + H2O
thiocholine + 3-methylbutyrate
show the reaction diagram
recombinant enzyme shows less than 1% activity compared to acetylthiocholine
-
?
acetyl(beta-methyl)thiocholine iodide + H2O
1-methyl(thio)choline iodide + acetate
show the reaction diagram
-
-
-
?
acetyl-(beta-methyl)thiocholine + H2O
(beta-methyl)thiocholine + acetate
show the reaction diagram
-
-
-
?
acetyl-(beta-methyl)thiocholine iodide + H2O
acetate + methylthiocholine iodide
show the reaction diagram
-
-
-
?
acetyl-beta-methyl-thiocholine + H2O
beta-methyl-thiocholine + acetate
show the reaction diagram
-
-
-
?
acetyl-beta-methylcholine + H2O
methylcholine + acetate
show the reaction diagram
-
-
-
?
acetyl-beta-methylthiocholine + H2O
beta-methylthiocholine + acetate
show the reaction diagram
-
-
-
?
acetyl-beta-methylthiocholine + H2O
? + acetate
show the reaction diagram
-
-
-
?
acetyl-homo-thiocholine + H2O
?
show the reaction diagram
-
recombinant enzyme shows less than 10% activity compared to acetylthiocholine
-
-
?
acetyl-homo-thiocholine + H2O
?
show the reaction diagram
recombinant enzyme shows less than 10% activity compared to acetylthiocholine
-
-
?
acetyl-[beta-methyl]thiocholine + H2O
acetate + [beta-methyl]thiocholine
show the reaction diagram
-
-
-
?
acetyl-[beta-methyl]thiocholine + H2O
acetate + [beta-methyl]thiocholine
show the reaction diagram
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
acetylcholinesterase plays in vivo a key role in cholinergic transmission by catalysing the rapid hydrolysis of the neurotransmitter acetylcholine into acetate and choline
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
acetylcholine protects cardiomyocytes from prolonged hypoxia through activation of the PI3K/Akt/HIF-1alpha/VEGF pathway and that cardiomyocyte-derived VEGF promotes angiogenesis in a paracrine fashion
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
Cimex lectularius Bedbug
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
esteratic and anionic subsites act together to achieve substrate binding specificity
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
key enzyme in the central and peripheral nervous systems where it is responsible for the hydrolysis of neurotransmitter acetylcholine into choline and acetate
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
the enzyme might be involved in slowing of neurodegeneration in Alzheimer’s and Parkinson’s diseases, overview
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
substrate traffic in AChE involves at least two binding sites, the catalytic and peripheral anionic sites, which are allosterically related and involved in substrate inhibition, structure-function relationship analysis, overview
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
fast hydrolysis
-
?
acetylcholine + H2O
?
show the reaction diagram
-
-
-
-
-
acetylcholine + H2O
?
show the reaction diagram
-
-
-
-
-
acetylcholine + H2O
?
show the reaction diagram
-
-
-
-
-
acetylcholine + H2O
?
show the reaction diagram
-
inactivation of transmitter substance operating in cholinergic neurotransmission
-
-
-
acetylcholine + H2O
?
show the reaction diagram
-
inactivation of transmitter substance operating in cholinergic neurotransmission
-
-
-
acetylcholine + H2O
?
show the reaction diagram
-
inactivation of transmitter substance operating in cholinergic neurotransmission
-
-
-
acetylcholine + H2O
?
show the reaction diagram
-
inactivation of transmitter substance operating in cholinergic neurotransmission
-
-
-
acetylcholine + H2O
?
show the reaction diagram
-
inactivation of transmitter substance operating in cholinergic neurotransmission
-
-
-
acetylcholine + H2O
?
show the reaction diagram
-
inactivation of transmitter substance operating in cholinergic neurotransmission
-
-
-
acetylcholine + H2O
?
show the reaction diagram
-
inactivation of transmitter substance operating in cholinergic neurotransmission
-
-
-
acetylcholine + H2O
?
show the reaction diagram
-
inactivation of transmitter substance operating in cholinergic neurotransmission
-
-
-
acetylcholine + H2O
?
show the reaction diagram
-
synaptic transmission, termination of impulse transmission at cholinergic synapses by hydrolysis
-
-
-
acetylcholine + H2O
?
show the reaction diagram
Drosophila melanogaster MH19
-
-
-
-
-
acetylcholine chloride + H2O
choline chloride + acetate
show the reaction diagram
-
-
-
?
acetylcholine chloride + H2O
acetate + choline chloride
show the reaction diagram
-
-
-
?
acetylcholine iodide + H2O
acetate + choline iodide
show the reaction diagram
-
-
-
?
acetylcholine iodide + H2O
acetate + choline iodide
show the reaction diagram
-
-
-
?
acetylcholine iodide + H2O
acetate + choline iodide
show the reaction diagram
-
-
-
?
acetylcholine iodide + H2O
acetate + choline iodide
show the reaction diagram
-
-
-
?
acetylcholine iodide + H2O
acetate + choline iodide
show the reaction diagram
-
-
-
?
acetylcholine iodide + H2O
acetate + choline iodide
show the reaction diagram
-
-
-
?
acetylcholine iodide + H2O
acetate + choline iodide
show the reaction diagram
-
-
-
?
acetylcholine iodide + H2O
acetate + choline iodide
show the reaction diagram
-
-
-
?
acetylcholine iodide + H2O
acetate + choline iodide
show the reaction diagram
-
-
-
?
acetylcholine iodide + H2O
acetate + choline iodide
show the reaction diagram
-
-
-
?
acetylcholine iodide + H2O
acetate + choline iodide
show the reaction diagram
-
-
-
?
acetylcholine iodide + H2O
acetate + choline iodide
show the reaction diagram
-
-
-
-
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
detection using 5,5'-dithiobis(2-nitrobenzoic acid)
-
?
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
most efficiently hydrolyzed substrate
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
Nephotettix cincticeps Uhler
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
best substrate
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
best substrate
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
best substrate
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
best substrate
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
best substrate
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
preferred substrate
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
100% activity
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
100% activity
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
catalytic residues are Ser200 and Trp84
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
fast hydrolysis
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
isoform AChE2 has approximately 2500fold greater catalytic efficiency toward acetylthiocholine and butyrylthiocholine than isoform AChE1
-
?
acetylthiocholine chloride + H2O
thiocholine chloride + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine chloride + H2O
acetate + thiocholine chloride
show the reaction diagram
-
-
-
?
acetylthiocholine iodide + H2O
acetate + thiocholine iodide
show the reaction diagram
-
-
-
?
acetylthiocholine iodide + H2O
acetate + thiocholine iodide
show the reaction diagram
-
-
-
?
acetylthiocholine iodide + H2O
acetate + thiocholine iodide
show the reaction diagram
-
-
-
?
acetylthiocholine iodide + H2O
acetate + thiocholine iodide
show the reaction diagram
-
-
-
?
acetylthiocholine iodide + H2O
acetate + thiocholine iodide
show the reaction diagram
-
-
-
?
acetylthiocholine iodide + H2O
acetate + thiocholine iodide
show the reaction diagram
detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB
-
?
acetylthiocholine iodide + H2O
acetate + thiocholine iodide
show the reaction diagram
-
detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB
-
?
acetylthiocholine iodide + H2O
acetate + thiocholine iodide
show the reaction diagram
-
detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB
-
?
acetylthiocholine iodide + H2O
acetate + thiocholine iodide
show the reaction diagram
-
detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB
-
?
acetylthiocholine iodide + H2O
acetate + thiocholine iodide
show the reaction diagram
-
detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB
-
?
acetylthiocholine iodide + H2O
acetate + thiocholine iodide
show the reaction diagram
-
detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB
-
?
acetylthiocholine iodide + H2O
acetate + thiocholine iodide
show the reaction diagram
-
detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB
-
?
acetylthiocholine iodide + H2O
thiocholine iodide + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine iodide + H2O
thiocholine iodide + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine iodide + H2O
thiocholine iodide + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine iodide + H2O
thiocholine iodide + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine iodide + H2O
thiocholine iodide + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine iodide + H2O
thiocholine iodide + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine iodide + H2O
thiocholine iodide + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine iodide + H2O
thiocholine iodide + acetate
show the reaction diagram
-
-
?
acetylthiocholine iodide + H2O
thiocholine iodide + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine iodide + H2O
thiocholine iodide + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine iodide + H2O
thiocholine iodide + acetate
show the reaction diagram
-
preferred substrate
-
?
acetylthiocholine iodide + H2O
thiocholine iodide + acetate
show the reaction diagram
-
highly preferred substrate
-
?
acetylthiocholine iodide + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine iodide + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
alkyl methylphosphonfluoridate + H2O
?
show the reaction diagram
-
oxime-assisted catalysis of organophosphates by AChE, mechanism, reaction system, overview
-
-
?
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
show the reaction diagram
-
-
-
?
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
show the reaction diagram
-
-
-
?
alpha-naphthyl acetate + H2O
naphthol + acetate
show the reaction diagram
-
-
-
?
aryl-acyl-amides + H2O
?
show the reaction diagram
-
-
-
-
?
benzoylthiocholine + H2O
thiocholine + benzoate
show the reaction diagram
-
recombinant enzyme shows about 1% activity compared to acetylthiocholine
-
?
benzoylthiocholine + H2O
thiocholine + benzoate
show the reaction diagram
recombinant enzyme shows about 1% activity compared to acetylthiocholine
-
?
benzoylthiocholine iodide + H2O
thiocholine iodide + benzoate
show the reaction diagram
-
22.2% activity compared to acetylthiocholine
-
?
butylthiocholine + H2O
thiocholine + butanol
show the reaction diagram
-
-
-
?
butyrylthiocholine + H2O
butyrate + thiocholine
show the reaction diagram
-
-
-
?
butyrylthiocholine + H2O
butyrate + thiocholine
show the reaction diagram
-
-
-
?
butyrylthiocholine + H2O
butyrate + thiocholine
show the reaction diagram
-
-
-
?
butyrylthiocholine + H2O
butyrate + thiocholine
show the reaction diagram
-
-
-
?
butyrylthiocholine + H2O
butyrate + thiocholine
show the reaction diagram
-
-
-
?
butyrylthiocholine + H2O
butyrate + thiocholine
show the reaction diagram
-
-
-
?
butyrylthiocholine + H2O
butyrate + thiocholine
show the reaction diagram
-
-
-
?
butyrylthiocholine + H2O
butyrate + thiocholine
show the reaction diagram
-
-
-
?
butyrylthiocholine + H2O
butyrate + thiocholine
show the reaction diagram
-
-
?
butyrylthiocholine + H2O
butyrate + thiocholine
show the reaction diagram
-
-
?
butyrylthiocholine + H2O
butyrate + thiocholine
show the reaction diagram
-
-
?
butyrylthiocholine + H2O
butyrate + thiocholine
show the reaction diagram
Nephotettix cincticeps Uhler
-
-
-
?
butyrylthiocholine + H2O
butyrate + thiocholine
show the reaction diagram
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
worst substrate
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
native enzyme shows about 50% activity and recombinant enzyme shows about 45% activity compared to acetylthiocholine
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
recombinant enzyme shows about 3% activity compared to acetylthiocholine
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
isoform AChE2 has approximately 2500fold greater catalytic efficiency toward acetylthiocholine and butyrylthiocholine than isoform AChE1
-
?
butyrylthiocholine + H2O
thiocholine + butanoate
show the reaction diagram
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butanoate
show the reaction diagram
-
-
very bad substrate
?
butyrylthiocholine iodide + H2O
thiocholine iodide + butyrate
show the reaction diagram
-
-
-
?
butyrylthiocholine iodide + H2O
thiocholine iodide + butyrate
show the reaction diagram
-
-
-
?
butyrylthiocholine iodide + H2O
thiocholine iodide + butyrate
show the reaction diagram
-
-
?
butyrylthiocholine iodide + H2O
thiocholine iodide + butyrate
show the reaction diagram
-
low activity
-
?
butyrylthiocholine iodide + H2O
thiocholine iodide + butyrate
show the reaction diagram
-
41.7% activity compared to acetylthiocholine
-
?
carbachol + H2O
?
show the reaction diagram
-
slow hydrolysis
-
-
?
cyclopentylcarbonylthiocholine + H2O
thiocholine + cyclopentanecarboxylate
show the reaction diagram
-
recombinant enzyme shows about 4% activity compared to acetylthiocholine
-
?
cyclopentylcarbonylthiocholine + H2O
thiocholine + cyclopentanecarboxylate
show the reaction diagram
recombinant enzyme shows less than 1% activity compared to acetylthiocholine
-
?
cyclopropylcarbonylthiocholine + H2O
thiocholine + cyclopropanecarboxylate
show the reaction diagram
-
recombinant enzyme shows about 4% activity compared to acetylthiocholine
-
?
cyclopropylcarbonylthiocholine + H2O
thiocholine + cyclopropanecarboxylate
show the reaction diagram
recombinant enzyme shows about 5% activity compared to acetylthiocholine
-
?
diisopropyl phosphofluoridate + H2O
?
show the reaction diagram
-
mutant G117H, no activity with the wild-type enzyme
-
-
?
diisopropyl phosphofluoridate + H2O
?
show the reaction diagram
-
mutant G122H/Y124Q/S125T, no activity with the wild-type enzyme
-
-
?
echothiophate + H2O
?
show the reaction diagram
-
mutant G117H, no activity with the wild-type enzyme
-
-
?
echothiophate + H2O
?
show the reaction diagram
-
mutant G122H/Y124Q/S125T, no activity with the wild-type enzyme
-
-
?
edrophonium chloride + H2O
?
show the reaction diagram
-
-
-
-
?
hexanoylthiocholine + H2O
thiocholine + hexanoate
show the reaction diagram
-
recombinant enzyme shows about 6% activity compared to acetylthiocholine
-
?
hexanoylthiocholine + H2O
thiocholine + hexanoate
show the reaction diagram
recombinant enzyme shows less than 1% activity compared to acetylthiocholine
-
?
indophenylacetate + H2O
indophenol + acetate
show the reaction diagram
-
-
-
?
isobutyrylthiocholine + H2O
thiocholine + isobutyrate
show the reaction diagram
recombinant enzyme shows about 15% activity compared to acetylthiocholine
-
?
isobutyrylthiocholine + H2O
thiocholine + isobutyrate
show the reaction diagram
-
recombinant enzyme shows about 2% activity compared to acetylthiocholine
-
?
Leu + Arg
Tyr + Gly
show the reaction diagram
-
-
-
?
Leu + Met
substance P
show the reaction diagram
-
-
-
?
neuropeptides + H2O
?
show the reaction diagram
-
degradation
-
-
-
paraoxon + H2O
?
show the reaction diagram
-
mutant G117H, no activity with the wild-type enzyme
-
-
?
paraoxon + H2O
?
show the reaction diagram
-
mutant G122H/Y124Q/S125T, no activity with the wild-type enzyme
-
-
?
pentanoylthiocholine + H2O
thiocholine + pentanoate
show the reaction diagram
-
recombinant enzyme shows about 5% activity compared to acetylthiocholine
-
?
pentanoylthiocholine + H2O
thiocholine + pentanoate
show the reaction diagram
recombinant enzyme shows about 5% activity compared to acetylthiocholine
-
?
Phe + Leu
Gly + Gly + Gly
show the reaction diagram
-
-
-
?
phenylacetylthiocholine + H2O
thiocholine + phenylacetate
show the reaction diagram
recombinant enzyme shows about 3% activity compared to acetylthiocholine
-
?
phenylacetylthiocholine + H2O
thiocholine + phenylacetate
show the reaction diagram
-
recombinant enzyme shows about 7% activity compared to acetylthiocholine
-
?
pivaloylthiocholine + H2O
thiocholine + pivalate
show the reaction diagram
-
recombinant enzyme shows about 5% activity compared to acetylthiocholine
-
?
pivaloylthiocholine + H2O
thiocholine + pivalate
show the reaction diagram
recombinant enzyme shows less than 1% activity compared to acetylthiocholine
-
?
propionylcholine chloride + H2O
choline chloride + propionate
show the reaction diagram
-
-
-
?
propionylthiocholine + H2O
propanoate + thiocholine
show the reaction diagram
-
-
-
?
propionylthiocholine + H2O
propanoate + thiocholine
show the reaction diagram
-
-
-
?
propionylthiocholine + H2O
propanoate + thiocholine
show the reaction diagram
-
-
-
?
propionylthiocholine + H2O
propanoate + thiocholine
show the reaction diagram
-
-
-
?
propionylthiocholine + H2O
propanoate + thiocholine
show the reaction diagram
-
-
-
?
propionylthiocholine + H2O
propanoate + thiocholine
show the reaction diagram
-
-
-
?
propionylthiocholine + H2O
propanoate + thiocholine
show the reaction diagram
Nephotettix cincticeps Uhler
-
-
-
?
propionylthiocholine + H2O
propanoate + thiocholine
show the reaction diagram
-
-
-
?
propionylthiocholine + H2O
propanoate + thiocholine
show the reaction diagram
-
preferred over acetylthiocholine
-
?
propionylthiocholine + H2O
thiocholine + propionate
show the reaction diagram
-
-
-
?
propionylthiocholine + H2O
thiocholine + propionate
show the reaction diagram
-
-
-
?
propionylthiocholine + H2O
thiocholine + propionate
show the reaction diagram
-
-
-
?
propionylthiocholine + H2O
thiocholine + propionate
show the reaction diagram
-
-
-
?
propionylthiocholine + H2O
thiocholine + propionate
show the reaction diagram
-
-
-
?
propionylthiocholine + H2O
thiocholine + propionate
show the reaction diagram
-
-
?
propionylthiocholine + H2O
thiocholine + propionate
show the reaction diagram
-
good substrate
-
?
propionylthiocholine + H2O
thiocholine + propionate
show the reaction diagram
native and recombinant enzyme show about 70% activity compared to acetylthiocholine
-
?
propionylthiocholine + H2O
thiocholine + propionate
show the reaction diagram
-
recombinant enzyme shows about 52% activity compared to acetylthiocholine
-
?
propionylthiocholine chloride + H2O
thiocholine chloride + propionate
show the reaction diagram
-
-
-
?
propionylthiocholine iodide + H2O
thiocholine iodide + propionate
show the reaction diagram
-
-
-
?
propionylthiocholine iodide + H2O
thiocholine iodide + propionate
show the reaction diagram
-
-
-
?
propionylthiocholine iodide + H2O
thiocholine iodide + propionate
show the reaction diagram
-
-
?
propionylthiocholine iodide + H2O
thiocholine iodide + propionate
show the reaction diagram
-
preferred substrate
-
?
propionylthiocholine iodide + H2O
thiocholine iodide + propionate
show the reaction diagram
-
74.6% activity compared to acetylthiocholine
-
?
propylthiocholine + H2O
thiocholine + propanol
show the reaction diagram
-
-
-
?
S-acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB
-
?
S-acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB
-
?
S-acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB
-
?
S-acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB
-
?
S-acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB
-
?
S-acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB
-
?
S-acetylthiocholine iodide + H2O
acetate + thiocholine iodide
show the reaction diagram
-
detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB
-
?
S-acetylthiocholine iodide + H2O
acetate + thiocholine iodide
show the reaction diagram
-
detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB
-
?
S-acetylthiocholine iodide + H2O
acetate + thiocholine iodide
show the reaction diagram
-
detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB
-
?
S-acetylthiocholine iodide + H2O
acetate + thiocholine iodide
show the reaction diagram
-
detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB
-
?
S-acetylthiocholine iodide + H2O
acetate + thiocholine iodide
show the reaction diagram
-
detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB
-
?
S-acetylthiocholine iodide + H2O
acetate + thiocholine iodide
show the reaction diagram
-
detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB
-
?
S-acetylthiocholine iodide + H2O
acetate + thiocholine iodide
show the reaction diagram
detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB, the enzyme contains a Ser, Glu, and His catalytic triad, overview
-
?
S-butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
?
S-butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
?
S-butyrylthiocholine iodide + H2O
thiocholine iodide + butyrate
show the reaction diagram
-
-
-
?
succinyldicholine + H2O
2 choline + succinate
show the reaction diagram
-
-
-
?
[leu5] enkephalin + H2O
Tyr + Leu
show the reaction diagram
-
-
-
?
[met5] enkephalins + H2O
Tyr + Met
show the reaction diagram
-
-
-
?
methylthiocholine + H2O
thiocholine + methanol
show the reaction diagram
-
-
-
?
additional information
?
-
-
-
-
-
-
additional information
?
-
-
-
-
-
-
additional information
?
-
-
-
-
-
-
additional information
?
-
-
-
-
-
-
additional information
?
-
-
-
-
-
-
additional information
?
-
-
acts on a variety of acetic acid esters, also catalyzes transacetylation
-
-
-
additional information
?
-
-
not: beta-endorphin, angiotensin, oxytoxin, vasopressin
-
-
-
additional information
?
-
-
complex with fasciculin-2 exhibits hydrolytic activity in a buryrylcholinesterase-like kinetics, the switch appears to be a consequence of steric obstruction, but also the consequence of subtle rapid conformational changes around the catalytic site
-
-
?
additional information
?
-
-
pivotal role in the cholinergic system, rapid termination of nerve impulse transmission
-
-
?
additional information
?
-
pivotal role in the cholinergic system, rapid termination of nerve impulse transmission
-
-
?
additional information
?
-
-
no substrate: S-butyrylthiocholine
-
-
-
additional information
?
-
-
calcium-activated BuchE, EC 3.1.1.8, acts as a major protective mechanism against suicide inhibition of AchE by organophosphates in this non-neuronal tissue, overview
-
-
-
additional information
?
-
-
the enzyme is involved in the morphogenetic processes of neuronal and non-neuronal tissues
-
-
-
additional information
?
-
-
the reactivation of nerve agent-inhibited acetylcholinesterase by oxime is the most important step in the treatment of nerve agent poisoning, overview
-
-
-
additional information
?
-
-
lethal effects due to enzyme inhibition in vivo appear at inhibition levels over 50%
-
-
-
additional information
?
-
-
substrate and product trafficking through the active center gorge of the enzyme analyzed by crystallography and equilibrium binding, binding structures, overview
-
-
-
additional information
?
-
-
acetylcholinesterase is a serine hydrolase that catalyze the hydrolysis of acetylcholine, thus regulating cholinergic neurotransmission
-
-
-
additional information
?
-
-
AChE is an acetylcholine-hydrolyzing enzyme and is implicated in cognitive functions and probably plays important roles in neurodegenerative disorders, including Alzheimer's disease
-
-
-
additional information
?
-
-
brain acetylcholinesterase activity controls systemic cytokine levels through the cholinergic anti-inflammatory pathway, overview
-
-
-
additional information
?
-
-
inhibition of AChE, along with the butyrylcholinesterase, and restoration of acetylcholine is a therapeutic strategy in treatment of Alzheimer's disease and other forms of dementia
-
-
-
additional information
?
-
-
presenilin 1, PS1, is required for enzyme activity in the brain, PS1/A246E transgenic mice have altered AChE activity in several regions also vulnerable in Alzheimer pathology, overview
-
-
-
additional information
?
-
active site structure and substrate channels of wild-type and mutant enzymes, overview
-
-
-
additional information
?
-
Checx1, Checx2, and Checx3 are three carboxylesterases, that perform the acetylcholineesterase reaction, overview
-
-
-
additional information
?
-
-
development of an assay method for quantification of the product of enzymatic reaction using substrate as internal standard, thus eliminating the need for addition of an internal standard, mass spectrometric analysis, overview
-
-
-
additional information
?
-
-
the catalytic triad is formed by His440, Glu327, and Ser200, Trp84 and Trp279 are important for the enzyme activity
-
-
-
additional information
?
-
-
AChE1 is also activity with propionylthiocholine iodide and butyrylthiocholine iodide
-
-
-
additional information
?
-
-
activity detection using a capillary electrophoresis, EMMA, method, screening method development and optimization of experimental conditions, overview
-
-
-
additional information
?
-
-
bioassay for inhibition of fibril formation, i.e. Thioflavin T assay
-
-
-
additional information
?
-
-
the ensemble of compound 1 and compound 2 can be used for the AChE activity assay and the inhibitor-screening by making use of the aggregation-induced emission feature of tetraphenyl ethylene compounds, method development, overview
-
-
-
additional information
?
-
isoform AChE1 is the dominant activity in Ctenocephalides felis imagoes
-
-
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
acetylcholinesterase plays in vivo a key role in cholinergic transmission by catalysing the rapid hydrolysis of the neurotransmitter acetylcholine into acetate and choline
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
acetylcholine protects cardiomyocytes from prolonged hypoxia through activation of the PI3K/Akt/HIF-1alpha/VEGF pathway and that cardiomyocyte-derived VEGF promotes angiogenesis in a paracrine fashion
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
E2FZ90
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
key enzyme in the central and peripheral nervous systems where it is responsible for the hydrolysis of neurotransmitter acetylcholine into choline and acetate
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
the enzyme might be involved in slowing of neurodegeneration in Alzheimer’s and Parkinson’s diseases, overview
-
?
acetylcholine + H2O
?
show the reaction diagram
-
-
-
-
-
acetylcholine + H2O
?
show the reaction diagram
-
-
-
-
-
acetylcholine + H2O
?
show the reaction diagram
-
-
-
-
-
acetylcholine + H2O
?
show the reaction diagram
-
inactivation of transmitter substance operating in cholinergic neurotransmission
-
-
-
acetylcholine + H2O
?
show the reaction diagram
-
inactivation of transmitter substance operating in cholinergic neurotransmission
-
-
-
acetylcholine + H2O
?
show the reaction diagram
-
inactivation of transmitter substance operating in cholinergic neurotransmission
-
-
-
acetylcholine + H2O
?
show the reaction diagram
-
inactivation of transmitter substance operating in cholinergic neurotransmission
-
-
-
acetylcholine + H2O
?
show the reaction diagram
-
inactivation of transmitter substance operating in cholinergic neurotransmission
-
-
-
acetylcholine + H2O
?
show the reaction diagram
-
inactivation of transmitter substance operating in cholinergic neurotransmission
-
-
-
acetylcholine + H2O
?
show the reaction diagram
-
inactivation of transmitter substance operating in cholinergic neurotransmission
-
-
-
acetylcholine + H2O
?
show the reaction diagram
-
inactivation of transmitter substance operating in cholinergic neurotransmission
-
-
-
acetylcholine + H2O
?
show the reaction diagram
-
synaptic transmission, termination of impulse transmission at cholinergic synapses by hydrolysis
-
-
-
acetylcholine + H2O
?
show the reaction diagram
Drosophila melanogaster MH19
-
-
-
-
-
acetylcholine + H2O
acetate + choline
show the reaction diagram
Cimex lectularius Bedbug
-
-
-
?
acetylcholine chloride + H2O
choline chloride + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
neuropeptides + H2O
?
show the reaction diagram
-
degradation
-
-
-
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
additional information
?
-
-
-
-
-
-
additional information
?
-
-
-
-
-
-
additional information
?
-
-
-
-
-
-
additional information
?
-
-
-
-
-
-
additional information
?
-
-
-
-
-
-
additional information
?
-
-
pivotal role in the cholinergic system, rapid termination of nerve impulse transmission
-
-
?
additional information
?
-
Q67BC1, Q67BC2
pivotal role in the cholinergic system, rapid termination of nerve impulse transmission
-
-
?
additional information
?
-
-
calcium-activated BuchE, EC 3.1.1.8, acts as a major protective mechanism against suicide inhibition of AchE by organophosphates in this non-neuronal tissue, overview
-
-
-
additional information
?
-
-
the enzyme is involved in the morphogenetic processes of neuronal and non-neuronal tissues
-
-
-
additional information
?
-
-
the reactivation of nerve agent-inhibited acetylcholinesterase by oxime is the most important step in the treatment of nerve agent poisoning, overview
-
-
-
additional information
?
-
-
acetylcholinesterase is a serine hydrolase that catalyze the hydrolysis of acetylcholine, thus regulating cholinergic neurotransmission
-
-
-
additional information
?
-
-
AChE is an acetylcholine-hydrolyzing enzyme and is implicated in cognitive functions and probably plays important roles in neurodegenerative disorders, including Alzheimer's disease
-
-
-
additional information
?
-
-
brain acetylcholinesterase activity controls systemic cytokine levels through the cholinergic anti-inflammatory pathway, overview
-
-
-
additional information
?
-
-
inhibition of AChE, along with the butyrylcholinesterase, and restoration of acetylcholine is a therapeutic strategy in treatment of Alzheimer's disease and other forms of dementia
-
-
-
additional information
?
-
-
presenilin 1, PS1, is required for enzyme activity in the brain, PS1/A246E transgenic mice have altered AChE activity in several regions also vulnerable in Alzheimer pathology, overview
-
-
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
aluminium chloride
-
activates the enzyme in vitro and in vivo after oral treatment
ammonium sulfate
-
activates optimally at 0.2 M
Ca2+
-
divalent metal ion required
Ca2+
-
activation above 1 mM
Iron
-
in vitro, iron promotes a significant increase in AChE activity in brain (52%) and liver (53%) at the higher concentration (2.6 mM). In vivo, a significant increase in enzyme activity is observed in the presence of 15 mg/l in both, brain (62%) and liver tissue (70%)
Mg2+
-
divalent metal ion required, highest activity
Mg2+
-
activation above 1 mM
Mg2+
-
omission leads to a 20% decrease in activity
Mg2+
-
ameliorates inhibitory effects of AChE inhibitors
Mn2+
-
divalent metal ion required, effective in lowest concentration
Mn2+
-
activation above 1 mM
additional information
-
AchE is not affected by Ca2+
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
(+)-(1R,3R,6S)-9-benzyl-3-fluoro-2,4-dioxa-9-aza-3-phosphadecalin 3-oxide
-
-
(+)-(1R,3S,6S)-9-benzyl-3-fluoro-2,4-dioxa-9-aza-3-phosphadecalin 3-oxide
-
-
(+)-(1S,3R,6S)-9-benzyl-3-fluoro-2,4-dioxa-9-aza-3-phosphadecalin 3-oxide
-
-
(+)-(1S,3S,6S)-9-benzyl-3-fluoro-2,4-dioxa-9-aza-3-phosphadecalin 3-oxide
-
-
(+)-2-carene
-
50% inhibition at 0.90 mM
(+)-3-carene
-
50% inhibition at 0.20 mM
(+)-7-deoxy-O6-buxafurandiene
-
isolated from Buxus hyrcana
(+)-alpha-pinene
-
50% inhibition at 0.4 mM
(+)-benzoylbuxidienine
-
isolated from Buxus hyrcana
(+)-borneol
-
1 mM, 22.2% inhibition
(+)-buxapapillinine
-
isolated from Buxus hyrcana
(+)-buxaquamarine
-
isolated from Buxus hyrcana
(+)-Camphor
-
1 mM, 26.4% inhibition
(+)-cis-verbenol
-
1 mM, 17.7% inhibition
-
(+)-fenchol
-
1 mM, 37.7% inhibition
(+)-fenchone
-
1 mM, 23.3 inhibition
(+)-haemanthamine
-
-
(+)-huperzine A
-
synthetic enantiomer of the anti-Alzheimer drug (-)-huperzine A and of its natural homologue (-)-huperzine B, interacts with the anionic subsite of the active site
(+)-irehine
-
isolated from Buxus hyrcana
(+)-limonene
-
isolated from the ethanolic extract from the fruits of Pimpinella anisoides
(+)-O6-buxafurandiene
-
isolated from Buxus hyrcana
(+)-sabinene
-
isolated from the ethanolic extract from the fruits of Pimpinella anisoides
(+)-trans-myrtanol
-
1 mM, 37.15% inhibition
(-)-(1R,3R,6R)-9-benzyl-3-fluoro-2,4-dioxa-9-aza-3-phosphadecalin 3-oxide
-
-
(-)-(1R,3S,6R)-9-benzyl-3-fluoro-2,4-dioxa-9-aza-3-phosphadecalin 3-oxide
-
-
(-)-(1S,3R,6R)-9-benzyl-3-fluoro-2,4-dioxa-9-aza-3-phosphadecalin 3-oxide
-
-
(-)-(1S,3S,6R)-9-benzyl-3-fluoro-2,4-dioxa-9-aza-3-phosphadecalin 3-oxide
-
-
(-)-10,10-dimethylhuperzine A
-
-
(-)-3-O-acetyl-spectaline
-
isolated from flowers of Senna spectabilis
(-)-alpha-pinene
-
50% inhibition at 0.44 mM
(-)-beta-pinene
-
1 mM, 48.5% inhibition
(-)-borneol
-
1 mM, 22.6% inhibition
(-)-Camphor
-
1 mM, 21.2% inhibition
(-)-fenchone
-
1 mM, 28.2% inhibition
(-)-galanthamine
-
isolated from Galanthus woronowii
(-)-huperzine A
-
anti-Alzheimer drug
(-)-huperzine B
-
-
(-)-myrtenol
-
1 mM, 15.0% inhibition
(-)-phenserine
-
-
(-)-S-3-[1-(dimethylamino)ethyl]phenol
-
competitive reversible inhibitor
(-)-spectaline
-
isolated from flowers of Senna spectabilis
(-)-trans-myrtanol
-
1 mM, 37.4% inhibition
(-)-verbenone
-
1 mM, 12.6% inhibition
(1alpha,3beta,22R)-stigmast-5-ene-1,3,22-triol
-
i.e. haloxysterol A, isolated from Haloxylon recurvum
(1alpha,3beta,22R)-stigmasta-4,6-diene-1,3,22-triol
-
i.e. haloxysterol B, isolated from Haloxylon recurvum
(1alpha,3beta,5alpha,6beta,22R)-stigmastane-1,3,5,6,22-pentol
-
i.e. haloxysterol D, isolated from Haloxylon recurvum
(1S,2R)-N-(1-benzyl-2-hydroxy-3-(S)-[2-(1-benzylpiperidin-4-yl)ethylamino]-propyl)-5-nitro-N'-[(R)-1-phenylethyl]isophthalamide
-
-
(1S,2R)-N-(1-benzyl-2-hydroxy-3-(S)-[2-(1-benzylpiperidin-4-yl)ethylamino]-propyl)-5-[methyl(methylsulfonyl)-amino]-N'-[(R)-1-(4-fluorophenyl)ethyl]isophthalamide
-
-
(1S,2R)-N-(1-benzyl-2-hydroxy-3-(S)-[2-(1-benzylpiperidin-4-yl)ethylamino]-propyl)-5-[methyl(methylsulfonyl)amino]-N-[(R)-1-phenylethyl]isophthalamide
-
shows inhibitory effects on beta amyloid production of amyloid precursor protein-transfected HEK293 cells and mild protective effect against hydrogen peroxide-induced cell injury
(1S,2R)-N-(1-benzyl-2-hydroxy-3-(S)-[2-(1-benzylpiperidin-4-yl)ethylamino]-propyl)-N',N'-dipropyl-5-nitroisophthalamide
-
-
(1S,2R)-N-(1-benzyl-2-hydroxy-3-(S)-[2-(1-benzylpiperidin-4-yl)ethylamino]-propyl)-N',N'-dipropyl-5-[methyl(methylsulfonyl)amino]isophthalamide
-
-
(1S,2R)-N-(1-benzyl-2-hydroxy-3-(S)-[2-(1-benzylpiperidin-4-yl)ethylamino]-propyl)-N',N'-dipropylisophthalamide
-
-
(1S,2R)-N-(1-benzyl-2-hydroxy-3-(S)-[2-(1-benzylpiperidin-4-yl)ethylamino]-propyl)-N'-[(R)-1-(4-fluorophenyl)ethyl]-5-nitroisophthalamide
-
-
(1S,2R)-N-(1-benzyl-2-hydroxy-3-(S)-[2-(1-benzylpiperidin-4-yl)ethylamino]-propyl)-N'-[(R)-1-(4-fluorophenyl)ethyl]-isophthalamide
-
-
(1S,2R)-N-(1-benzyl-2-hydroxy-3-(S)-[2-(1-benzylpiperidin-4-yl)ethylamino]-propyl)-N'-[(R)-1-phenylethyl]isophthalamide
-
-
(1S,2S,11bS)-4-[2-(acetyloxy)ethyl]-5-methyl-1,2,3,4,4a,5,6,11b-octahydro[1,3]dioxolo[4,5-j]phenanthridine-1,2-diyl diacetate
-
-
(1S,2S,11bS)-4-[2-(acetyloxy)ethyl]-5-methyl-1,2,4a,5,6,11b-hexahydro[1,3]dioxolo[4,5-j]phenanthridine-1,2-diyl diacetate
-
-
(2-methoxy-7-methyl-2-oxido-2,3,4,5-tetrahydro-1,2-oxaphosphepin-6-yl)methanol
-
-
(22R)-22-hydroxystigmasta-4,9(11)-dien-3-one
-
i.e. haloxysterol C, isolated from Haloxylon recurvum
(24S)-ethylcholesta-7,9(11),22(E)-triene-3beta-ol
-
isolated from Haloxylon recurvum
(2E)-1,3-diphenylprop-2-en-1-one
-
-
(2E)-1-(5-chloro-2-hydroxyphenyl)-3-(4-chlorophenyl)prop-2-en-1-one
-
-
(2E)-3-(2-hydroxyphenyl)-1-phenylprop-2-en-1-one
-
-
(2E)-3-(3,4-dimethoxyphenyl)-1-phenylprop-2-en-1-one
-
-
(2E)-3-(3-hydroxyphenyl)-1-phenylprop-2-en-1-one
-
-
(2E)-3-(4-hydroxyphenyl)-1-phenylprop-2-en-1-one
-
-
(2E)-3-(4-methoxyphenyl)-1-phenylprop-2-en-1-one
-
-
(3,4-dimethoxyphenyl)(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)methanol
-
-
(3,4-dimethoxyphenyl)-(4-([(2-dimethylaminoethyl)-methylamino]methyl)phenyl)-methanone
-
-
(3,4-dimethoxyphenyl)-(4-([(2-methoxybenzyl)methylamino]methyl)phenyl)-methanone
-
-
(3,4-dimethoxyphenyl)-(4-([methyl-(3-methylbenzyl)amino]methyl)phenyl)methanone
-
-
(3,4-dimethoxyphenyl)-(4-([methyl-(3-nitrobenzyl)amino]methyl)phenyl)methanone
-
-
(3,4-dimethoxyphenyl)-(4-morpholin-4-ylmethylphenyl)methanone
-
-
(3,4-dimethoxyphenyl)-(4-[(methylprop-2-ynylamino)-methyl]phenyl)methanone
-
-
(3,4-dimethoxyphenyl)-{4-[(ethylpropylamino)methyl]phenyl}methanone
-
-
(3aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo(2,3-b)indol-5-yl (2-methylphenyl)carbamate
-
50% inhibition at 10 nM
(3aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo(2,3-b)indol-5-yl (4-isopropylphenyl)carbamate
-
50% inhibition at 760 nM
(3aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo(2,3-b)indol-5-yl ethylcarbamate
-
50% inhibition at 94 nM
(3aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo(2,3-b)indol-5-yl methylcarbamate
-
50% inhibition at 28 nM
(3aR)-3a,8-dimethyl-3,3a,8,8a-tetrahydro-2H-furo(2,3-b)indol-5-yl (2-methylphenyl)carbamate
-
50% inhibition at 13 nM
(3aR)-3a,8-dimethyl-3,3a,8,8a-tetrahydro-2H-furo(2,3-b)indol-5-yl (4-isopropylphenyl)carbamate
-
50% inhibition at 3860 nM
(3aR)-3a,8-dimethyl-3,3a,8,8a-tetrahydro-2H-furo(2,3-b)indol-5-yl ethylcarbamate
-
50% inhibition at 82 nM
(3aR)-3a,8-dimethyl-3,3a,8,8a-tetrahydro-2H-furo(2,3-b)indol-5-yl methylcarbamate
-
50% inhibition at 27 nM
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (2,3-dimethylphenyl)carbamate
-
-
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (2,4,6-trimethylphenyl)carbamate
-
-
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (2,4-dimethylphenyl)carbamate
-
-
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (2,5-dimethylphenyl)carbamate
-
-
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (2,6-dimethylphenyl)carbamate
-
-
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (2-ethylphenyl)carbamate
-
-
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (3,4-dimethylphenyl)carbamate
-
-
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (3-methylphenyl)carbamate
-
-
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (4-methylphenyl)carbamate
-
-
(3beta,4beta,5beta,6beta,8xi,9xi,14xi,17xi,22R)-4,28-dihydroxy-3-methoxy-1,26-dioxo-5,6:22,26-diepoxyergost-24-en-19-oic acid
-
-
(3beta,4beta,5beta,6beta,8xi,9xi,14xi,17xi,22R)-4,28-dihydroxy-3-methoxy-5,6:22,26-diepoxyergost-24-ene-1,26-dione
-
-
(3beta,4beta,6beta,8xi,9xi,14xi,17xi,22R)-4,6,27-trihydroxy-3-methoxy-22,26-epoxyergost-24-ene-1,26-dione
-
-
(3E)-3-([4-[2-(diethylamino)ethoxy]phenyl]methylidene)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
-
(3E)-3-([4-[3-(diethylamino)propoxy]phenyl]methylidene)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
-
(3E)-3-[(4-hydroxy-3,5-dimethoxyphenyl)methylidene]-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
-
(3E)-3-[(4-[2-[diethenyl(methylidene)-l5-azanyl]ethoxy]phenyl)methylidene]-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
-
(3E)-3-[(4-[3-[diethenyl(methylidene)-l5-azanyl]propoxy]phenyl)methylidene]-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
-
(3R,4aS,9bS)-9-(chloromethyl)-9b-[2-[(ethoxycarbonyl)(methyl)amino]ethyl]-6-methoxy-3,4,4a,9b-tetrahydrodibenzo[b,d]furan-3-yl ethyl carbonate
-
-
(3R,5aR)-3-methoxy-1-methyl-4,5,5a,6-tetrahydro-3H,8H-furo[3,4-e][1,2]oxaphosphepin-8-one 3-oxide
-
a diastereoisomeric bicyclic phosphonate analogue
(3S,5aR)-3-methoxy-1-methyl-4,5,5a,6-tetrahydro-3H,8H-furo[3,4-e][1,2]oxaphosphepin-8-one 3-oxide
-
a diastereoisomeric bicyclic phosphonate analogue
(4-([benzyl-(2-dimethylaminoethyl)amino]methyl)-phenyl)-(3,4-dimethoxyphenyl)methanone
-
-
(4-([benzyl-(2-hydroxyethyl)amino]methyl)phenyl)-(3,4-dimethoxyphenyl)methanone
-
-
(4-bromobenzoyl)phosphoramidic dichloride
-
-
(4-chlorobenzoyl)phosphoramidic dichloride
-
-
(4-methylbenzoyl)phosphoramidic dichloride
-
-
(4-[(benzylethylamino)methyl]phenyl)-(3,4-dimethoxyphenyl)methanone
-
-
(4-[(benzylmethylamino)methyl]phenyl)-(3,4-dimethoxyphenyl)methanone
-
-
(4-[(benzylmethylamino)methyl]phenyl)-(3-fluoro-4-methoxyphenyl)methanone
-
-
(4-[(benzylmethylamino)methyl]phenyl)-(4-methoxyphenyl)methanone
-
-
(4-[(benzylmethylamino)methyl]phenyl)naphthalen-2-yl-methanone
-
-
(4-[3-(benzylmethylamino)propenyl]phenyl)-(3,4-dimethoxyphenyl)methanone
-
-
(4aS,6R,8aS)-3-methoxy-11-methyl-5,6,10,11,13,14-hexahydro-4aH,9H-[1]benzofuro[3a,3,2-gh][3,4]benzoxazonin-6-ol
-
-
(4aS,6R,8aS)-3-methoxy-11-[8-[(4aS,6R,8aS)-3-methoxy-6-methyl-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11(12H)-yl]octyl]-5,6,9,10,11,12-hexahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-6-ol
-
-
(4aS,6R,8aS)-3-[[12-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)dodecyl]oxy]-6-hydroxy-11-methyl-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium
-
-
(4aS,6R,8aS)-3-[[8-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)octyl]oxy]-6-hydroxy-11-methyl-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium
-
-
(4aS,6R,8aS)-6-hydroxy-3-methoxy-11-[10-[(4aS,6R,8aS)-3-methoxy-6-methyl-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11(12H)-yl]decyl]-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium
-
-
(4aS,6R,8aS)-6-hydroxy-3-methoxy-11-[8-[(4aS,6R,8aS)-3-methoxy-6-methyl-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11(12H)-yl]octyl]-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium
-
-
(4aS,6R,8aS)-6-hydroxy-3-methyl-11-(10-phenyldecyl)-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium
-
-
(4aS,6R,8aS)-6-hydroxy-3-methyl-11-(8-phenyloctyl)-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium
-
-
(4beta,5beta,6beta,8xi,9xi,14xi,17xi,22R)-4,27-dihydroxy-5,6:22,26-diepoxyergosta-2,24-diene-1,26-dione
-
-
(5alpha,6alpha,7alpha,8xi,9xi,14xi,17xi,22R)-5-hydroxy-20-methyl-6,7:22,26-diepoxyergosta-2,24-diene-1,26-dione
-
-
(6,7-dimethoxyisoquinolin-1-yl)(2-methoxyphenyl)methanol
-
-
(6,7-dimethoxyisoquinolin-1-yl)(3,4-dimethoxyphenyl)methanol
-
-
(6,7-dimethoxyisoquinolin-1-yl)(3,4-dimethoxyphenyl)methanone
-
-
(7S,9R)-ar-turmerol
-
a synthetic bisabolane-type sesquiterpenoid derivative
(7S,9R)-dihydro-arturmerol
-
a synthetic bisabolane-type sesquiterpenoid derivative
(7S,9S)-arturmerol
-
a synthetic bisabolane-type sesquiterpenoid derivative
(7S,9S)-dihydro-ar-turmerol
-
a synthetic bisabolane-type sesquiterpenoid derivative
(8Z)-5,6-dihydro-8H-isoquino[1,2b]quinazolin-8-imine
-
-
(E)-1-(2,4-dichlorobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
-
-
-
(E)-1-(2,6-dichlorobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
-
-
-
(E)-1-(2-bromobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
-
-
-
(E)-1-(2-chloro-6-fluorobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
-
-
-
(E)-1-(2-chlorobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
-
-
-
(E)-1-(2-fluorobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
-
-
-
(E)-1-(2-methylbenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
-
-
-
(E)-1-(2-nitrobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium bromide
-
-
-
(E)-1-(3,4-dichlorobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
-
-
-
(E)-1-(3-bromobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
-
-
-
(E)-1-(3-chlorobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium bromide
-
-
-
(E)-1-(3-fluorobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
-
-
-
(E)-1-(3-methoxylbenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
-
-
-
(E)-1-(3-methylbenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
-
-
-
(E)-1-(4-bromobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
-
-
-
(E)-1-(4-chlorobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
-
-
-
(E)-1-(4-chloromethylbenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
-
-
-
(E)-1-(4-fluorobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
-
-
-
(E)-1-(4-methoxybenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
-
-
-
(E)-1-(4-nitrobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
-
-
-
(E)-1-(benzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium bromide
-
-
-
(E)-2-(4-[(diethylamino)methyl]benzylidene)-5,6-dimethoxy-2,3-dihydroinden-1-one
-
i.e. BZYX, an indanone derivative, and a dual-binding-site AChE inhibitor. BZYX also shows high neuroprotection from H2O2-induced apoptosis in PC12 cells and prevents loss of membrane potential, determination with fluorescent 5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazol-carbocyanine iodide, i.e. JC-1, overview
(E)-3-(3-((1-benzylpiperidin-4-yl)methoxy)phenyl)-1-(2-hydroxy-4,5-dimethoxyphenyl)prop-2-en-1-one
-
-
(E)-3-(3-(1-benzylpiperidin-4-yloxy)phenyl)-1-(2-hydroxy-4,5-dimethoxyphenyl)prop-2-en-1-one
-
-
(E)-3-(4-((1-benzylpiperidin-4-yl)methoxy)phenyl)-1-(2-hydroxy-4,5-dimethoxyphenyl)prop-2-en-1-one
-
-
(E)-3-(4-(1-benzylpiperidin-4-yloxy)phenyl)-1-(2-hydroxy-4,5-dimethoxyphenyl)prop-2-en-1-one
-
-
(E)-dimethyl 1-(2-oxodihydrofuran-3(2H)-ylidene)ethyl phosphate
-
-
(R)-(+)-endo-2-norbornyl-N-n-butylcarbamate
-
synthesis of enantiomers for stereoselective inhibition of AChE, overview. The S-enantiomer is more potent than the R-enantiomer
(R)-(+)-exo-2-norbornyl-N-n-butylcarbamate
-
synthesis of enantiomers for stereoselective inhibition of AChE, overview. The R-enantiomer is potent, while the S-enantiomer is inactive
(R)-(+)-fenoxon sulfoxide
-
-
(R)-(+)-fenthion sulfoxide
-
-
(R,S)-1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride
-
E2020, acetylcholinesterase inhibitor used in treatment of Alzheimer's diaease, inhibition kinetics
(R,S)-1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride
-
E2020, acetylcholinesterase inhibitor used in treatment of Alzheimer's diaease, interacts with the active site and the peripheral anionic site of the enzyme
(rac) fenoxon sulfoxide
-
-
(rac) fenthion sulfoxide
-
-
(RS)-tacrine(10)-hupyridone
-
-
(S)-(-)-endo-2-norbornyl-N-n-butylcarbamate
-
synthesis of enantiomers for stereoselective inhibition of AChE, overview. The S-enantiomer is more potent than the R-enantiomer
(S)-(-)-fenoxon sulfoxide
-
-
(S)-(-)-fenthion sulfoxide
-
-
(S)-ar-curcumene
-
a synthetic bisabolane-type sesquiterpenoid derivative
(S)-ar-turmerone
-
sesquiterpenoid, a competitive inhibitor
(S)-dihydro-ar-curcumene
-
a synthetic bisabolane-type sesquiterpenoid derivative
(S)-dihydro-ar-turmerone
-
a sesquiterpenoid, a noncompetitive inhibitor
(S,S)-(-)-bis(10)-hupyridone
-
enzyme binding structure, analysis using structure PDB ID 1H22, detailed overview
(S-(2-diethylamino)isobutyl)methylphosphonothioate
-
i.e. VR, detailed analysis of inhibition kinetics
(Z)-dimethyl 1-(2-oxodihydrofuran-3(2H)-ylidene)ethyl phosphate
-
-
1,1'-(ethane-1,1-diyldifuran-5,2-diyl)bis(trifluoroethanone)
-
-
1,1'-heptane-1,7-diylbis{2-[(E)-(hydroxyimino)methyl]pyridinium}
-
reversible inhibition, 0.000385 mM reduces the activity to 76%; reversible inhibition, reduces the activity to 89% and 44% at concentrations of 0.0000385 mM and 0.000385 mM, respectively
1,1'-nonane-1,9-diylbis{2-[(E)-(hydroxyimino)methyl]pyridinium}
-
reversible inhibition, enzyme activity is inhibited to 64% and 15% at 0.0000385 mM and 0.000385 mM, respectively
1,2,11,12-tetramethoxy-7-methyl-5,6-dihydro-4H,8H-pyrido[3,2,1-de]phenanthridinium
-
-
1,2,3,10,11-pentamethoxy-7-(methoxycarbonyl)-5,6-dihydro-4H,8H-pyrido[3,2,1-de]phenanthridinium
-
-
1,2,3,4,9,9a-hexahydroacridin-9-amine
-
-
1,2-diacetyllycorine
-
-
1,2-dihydrogalanthamine
-
from Narcissus jonquilla extract
1,5,6-trimethyl-9-oxo-7H,9H-pyrano[3,4,5-ij]isoquinolin-1-ium
-
-
1,5-Bis(4-allyldimethylammonium phenyl)pentan-3-one
-
-
1,5-Bis(4-allyldimethylammonium phenyl)pentan-3-one
-
-
1,5-bis(4-allyldimethylammoniumphenyl)-pentan-3-one dibromide
-
i.e. BW284c51, complete inhibition
1,5-bis(4-allyldimethylammoniumphenyl)-pentan-3-one dibromide
-
i.e. BW284c51, complete inhibition of SS ChE at 0.1 mM, complete inhibition of DS ChE at 0.1-0.01 mM
1,5-bis(4-allyldimethylammoniumphenyl)-pentan-3-one dibromide
-
i.e. BW284c51, 98% inhibition at 0.01 mM
1,5-bis(4-allyldimethylammoniumphenyl)-pentan-3-one dibromide
-
-
1,5-bis(4-allyldimethylammoniumphenyl)-pentan-3-one dibromide
-
i.e. BW284c51, inhibits to a lesser extent than the vertebrate enzyme
1,5-bis(4-allyldimethylammoniumphenyl)-pentan-3-one dibromide
-
i.e. BW284c51
1,5-bis(allyldimethylammoniumphenyl)pentan-3-one dibromide
-
-
1,8-cineole
-
isolated from Melaleuca atlernifolia
1,8-cineole
-
IC50 is 0.015 mg/ml
1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline
-
-
1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methylisoquinolinium
-
-
1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline
-
-
1-(4,6-dimethylpyrimidin-2-yl)-3-(4-methyl-3-nitrophenyl)guanidine
-
-
1-(4-cyclopentyl-6-methylpyrimidin-2-yl)-3-(2,4-dimethylphenyl)guanidine
-
-
1-(hydroxymethyl)-5-methyloctahydro-2H-quinolizinium
-
pKi-values and comparison with inhibitory effect on horse and Berrytheutis magister butyrylcholinesterase EC 3.1.1.8
1-benzyl-3-[(2E)-4-(4-benzylpiperazin-1-yl)but-2-en-1-yl]-1,3-dihydro-2H-thieno[2,3-d]imidazol-2-one
-
-
1-benzyl-3-[(2E)-4-(4-benzylpiperazin-1-yl)but-2-en-1-yl]-6-methyl-1,3-dihydro-2H-thieno[2,3-d]imidazol-2-one
-
-
1-benzyl-3-[4-(4-benzylpiperazin-1-yl)butyl]-1,3-dihydro-2H-thieno[2,3-d]imidazol-2-one
-
-
1-dodecyl-1H-pyrrole-2,5-dione
-
-
1-epideacetylbowdensine
-
-
1-ethyl-2-[(E)-(1-ethylquinolin-2(1H)-ylidene)methyl]quinolinium
-
-
1-ethyl-2-[(Z)-(1-ethyl[1]benzothieno[3,2-d][1,3]thiazol-2(1H)-ylidene)methyl]quinolinium
-
-
1-ethyl-6-methyl-2-[(1-methyl-1,2-dihydro[1]benzofuro[3,2-d][1,3]thiazol-2-yl)methyl]quinolinium
-
-
1-methyl-1-[2-oxo-3-(7-oxo-7H-dibenzo[de,h]quinolin-9-yl)propyl]pyrrolidinium
-
-
1-methyl-1-[3-oxo-4-(7-oxo-7H-dibenzo[de,h]quinolin-9-yl)butyl]pyrrolidinium
-
-
1-methyl-1-[4-oxo-5-(7-oxo-7H-dibenzo[de,h]quinolin-9-yl)pentyl]pyrrolidinium
-
-
1-methyl-3-(3-(methylamino)cyclohexyl)pyridinium
-
pKi-values and comparison with inhibitory effect on horse and Berrytheutis magister butyrylcholinesterase EC 3.1.1.8
1-methyl-3-(methylcarbamoyl)-1,4-dihydroquinolin-5-yl dimethylcarbamate
-
-
1-methyl-3-(morpholin-4-ylcarbonyl)-1,4-dihydroquinolin-5-yl dimethylcarbamate
-
-
1-methyl-4,5-dihydro[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridin-6-ium-2-olate
-
-
1-methyl-8,10-dioxatricyclo(7.2.1.0 2,7)dodeca-2,4,6-trien-5-yl (2-methylphenyl)carbamate
-
50% inhibition at 56 nM
1-methyl-8,10-dioxatricyclo(7.2.1.0 2,7)dodeca-2,4,6-trien-5-yl (4-isopropylphenyl)carbamate
-
50% inhibition at 4300 nM
1-methyl-8,10-dioxatricyclo(7.2.1.0 2,7)dodeca-2,4,6-trien-5-yl ethylcarbamate
-
50% inhibition at 830 nM
1-naphthyl phenothiazine carbamate
-
-
1-O-acetyllycorine
-
-
1-[3-(4-benzylpiperazin-1-yl)propyl]-3-methyl-1,3-dihydro-2H-thieno[2,3-d]imidazol-2-one
-
-
1-[5-(5-nitro-1H-indazol-3-yl)thiophen-3-yl]ethanone
-
-
1-[5-[(1E)-1-hydrazinylideneethyl]-2-methoxybenzyl]piperidine
-
-
1-[5-[(1H-benzimidazol-2-ylsulfanyl)methyl]furan-2-yl]-2,2,2-trifluoroethanone
-
-
1-[[(3-acetylpyridinium-1-yl)methoxy]methyl]-2-[(E)-(hydroxyimino)methyl]pyridinium diiodide
-
-
1-[[(3-butanoylpyridinium-1-yl)methoxy]methyl]-2-[(E)-(hydroxyimino)methyl]pyridinium diiodide
-
-
1-[[(3-decanoylpyridinium-1-yl)methoxy]methyl]-2-[(E)-(hydroxyimino)methyl]pyridinium diiodide
-
-
1-[[(3-heptanoylpyridinium-1-yl)methoxy]methyl]-2-[(E)-(hydroxyimino)methyl]pyridinium diiodide
-
-
1-[[(3-hexanoylpyridinium-1-yl)methoxy]methyl]-2-[(E)-(hydroxyimino)methyl]pyridinium diiodide
-
-
10-(2,2-dimethylpropanoyl)-10H-phenothiazine
-
relative potency EC 3.1.1.8 to EC3.1.1.7 is 4.7
10-(chloroacetyl)-10H-phenothiazine
-
relative potency EC 3.1.1.8 to EC3.1.1.7 is 7.3
10-(cyclobutylcarbonyl)-10H-phenothiazine
-
relative potency EC 3.1.1.8 to EC3.1.1.7 is 11.6
10-(cyclopropylcarbonyl)-10H-phenothiazine
-
relative potency EC 3.1.1.8 to EC3.1.1.7 is 1.9
10-(methoxyacetyl)-10H-phenothiazine
-
relative potency EC 3.1.1.8 to EC3.1.1.7 is 0.8
10-acetyl-10H-phenothiazine
-
relative potency EC 3.1.1.8 to EC3.1.1.7 is 1.1
10-butyryl-10H-phenothiazine
-
relative potency EC 3.1.1.8 to EC3.1.1.7 is 1.9
10-hydroxy-infractopicrin
-
isolated from Cortinarius infractus, inhibits acetylcholinesterase, but does not inhibit butyrylcholinesterase
10-isobutyryl-10H-phenothiazine
-
relative potency EC 3.1.1.8 to EC3.1.1.7 is 2.7
10-N-demethyl-10-N-(10-(4-(piperidin-1-ylmethyl)-phenoxy)decan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(12-(4-(piperidin-1-ylmethyl)-phenoxy)dodecan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(2-(4-(piperidin-1-ylmethyl)phenoxy)ethan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(3-(4-(piperidin-1-ylmethyl)phenoxy)propan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(4-(1-benzylpiperidin-4-yloxy)-butan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(4-(3-(1-morpholinoethyl)phenoxy)butan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(4-(4-((diethylamino)methyl)-phenoxy)butan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(4-(4-(morpholinomethyl)phenoxy)butan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(4-(4-(piperidin-1-ylmethyl)phenoxy)butan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(4-(4-(pyrrolidine-1-carbonyl)-phenoxy)butan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(5-(4-(piperidin-1-ylmethyl)phenoxy)pentan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(6-(1-benzylpiperidin-4-yloxy)-hexan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(6-(3-(1-morpholinoethyl)phenoxy)hexan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(6-(4-((diethylamino)methyl)-phenoxy)hexan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(6-(4-(morpholinomethyl)phenoxy)hexan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(6-(4-(piperidin-1-ylmethyl)phenoxy)hexan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(6-(4-(pyrrolidine-1-carbonyl)-phenoxy)hexan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(8-(4-(piperidin-1-ylmethyl)phenoxy)octan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(9-(4-(piperidin-1-ylmethyl)phenoxy)nonan-1-yl)-galanthamine
-
-
10-O-methylhostasine
-
a benzylphenethylamine alkaloid from Hosta plantaginea
10-propionyl-10H-phenothiazine
-
relative potency EC 3.1.1.8 to EC3.1.1.7 is 1.8
11-hydroxygalantamine
-
-
12-n-butoxy-demethoxykesselringine
-
-
13-methyl-5,8-dihydro-6H isoquino[1,2b]quinazolin-13-ium chloride
-
-
13-methyl-5,8-dihydro-6H-isoquino[1,2b]quinazolin-13-ium chloride
-
-
14-ethoxy-14-oxogalanthamine
-
-
19,20-dihydroervahanin A
-
-
19,20-dihydrotabernamine
-
-
1alpha,2alpha,6beta, 8alpha,15-pentaacetoxy-9beta-benzoyloxy-beta-agarofuran
-
-
1alpha,2alpha,6beta,8alpha-tetraacetoxy-9beta-benzoyloxy-15-hydroxy-beta-agarofuran
-
-
1alpha,2alpha,6beta-triacetoxy-9beta-benzoyloxy-15-hydroxy-beta-agarofuran
-
-
1alpha,2alpha,6beta-triacetoxy-9beta-benzoyloxy-8alpha,15-dihydroxy-beta-agarofuran
-
-
1alpha,6beta,8alpha-triacetoxy-9beta-furoyloxy-beta-agarofuran
-
IC50 is 0.0029 mg/ml
1alpha-acetoxy-6beta,9beta-difuroyloxy-4beta-hydroxy-beta-agarofuran
-
-
2'-ethylphenylgeneserine N-oxide
-
50% inhibition at 125 nM
2,2'-[[(E)-1,2-diphenylethene-1,2-diyl]bis(benzene-4,1-diyloxy)]diethanesulfonate
-
-
2,2-dichlorovinyl dimethyl phosphate
-
i.e. DDVP, reversible, detailed kinetic analysis
2,2-dichlorovinyl dimethyl phosphate
-
-
2,3,4-trimethylpyrimido[2,1-a]isoquinolin-5-ium
-
-
2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
-
2,3-dimethoxy-6-methyl-9H-xanthen-9-one
-
-
2-((Z)-(hydroxyimino)methyl)-1-methylpyridinium chloride
-
i.e. 2-PAM, reversible, detailed kinetic analysis
2-(1-piperidinyl)ethyl phenothiazine carbamate
-
-
2-(1-pyrrolidinyl)ethyl phenothiazine carbamate
-
-
2-(2-methyl-1H-imidazol-1-yl)-1-[2-(trifluoromethyl)-4a,10a-dihydro-10H-phenothiazin-10-yl]ethanone
-
-
2-(2-phenyl-2,3,4,5-tetrahydro-1,5-benzothiazepin-4-yl)phenol
-
2-(3-((1-benzylpiperidin-4-yl)methoxy)phenyl)-6,7-dimethoxy-4H-chromen-4-one
-
-
2-(3-((1-benzylpiperidin-4-yl)methoxy)phenyl)-6,7-dimethoxychroman-4-one
-
-
2-(3-(1-benzylpiperidin-4-yloxy)phenyl)-6,7-dimethoxy-4H-chromen-4-one
-
-
2-(3-(1-benzylpiperidin-4-yloxy)phenyl)-6,7-dimethoxychroman-4-one
-
-
2-(3-(2-(diethylamino)ethyl)phenoxy)-5,6-dimethoxyindan-1-one
-
-
2-(3-(2-(ethyl(methyl)amino)ethyl)phenoxy)-5,6-dimethoxy-indan-1-one
-
-
2-(3-(3-(diethylamino)propanoyl)phenoxy)-5,6-dimethoxy-indan-1-one
-
-
2-(3-methylphenyl)-4H-chromen-4-one
-
-
2-(4-((1-benzylpiperidin-4-yl)methoxy)phenyl)-6,7-dimethoxy-4H-chromen-4-one
-
-
2-(4-((1-benzylpiperidin-4-yl)methoxy)phenyl)-6,7-dimethoxychroman-4-one
-
-
2-(4-(1-benzylpiperidin-4-yloxy)phenyl)-6,7-dimethoxy-4H-chromen-4-one
-
-
2-(4-(1-benzylpiperidin-4-yloxy)phenyl)-6,7-dimethoxychroman-4-one
-
-
2-(4-(2-(diethylamino)acetyl)phenoxy)-5,6-dimethoxyindan-1-one
-
-
2-(4-(2-(diethylamino)ethyl)phenoxy)-5,6-dimethoxyindan-1-one
-
-
2-(4-(2-(ethyl(methyl)amino)acetyl)phenoxy)-5,6-dimethoxy-indan-1-one
-
-
2-(4-(2-(ethyl(methyl)amino)ethyl)phenoxy)-5,6-dimethoxy-indan-1-one
-
-
2-(4-(3-(diethylamino)propanoyl)phenoxy)-5,6-dimethoxy-indan-1-one
-
displays neuroprotective effect against H2O2-induced cell death
2-(4-(3-(diethylamino)propyl)phenoxy)-5,6-dimethoxyindan-1-one
-
-
2-(4-(3-(ethyl(methyl)amino)propanoyl)phenoxy)-5,6-dimethoxy-indan-1-one
-
-
2-(4-(4-(diethylamino)butanoyl)phenoxy)-5,6-dimethoxy-indan-1-one
-
-
2-(4-(4-(diethylamino)butyl)phenoxy)-5,6-dimethoxyindan-1-one
-
-
2-(4-(4-(ethyl(methyl)amino)butanoyl)phenoxy)-5,6-dimethoxy-indan-1-one
-
-
2-(4-methylphenyl)-4H-chromen-4-one
-
-
2-(4-morpholino)ethyl phenothiazine carbamate
-
-
2-(6-oxo-7,11-diazatricyclo(7.3.1.0 2,7)tridec-11-yl)ethyl acetate
-
pKi-values and comparison with inhibitory effect on horse and Berrytheutis magister butyrylcholinesterase EC 3.1.1.8
2-(dimethylamino)-7-ethyl-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)oxazin-4-one
-
50% inhibition at 0.011 mM
2-(dimethylamino)-7-isobutyl-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)oxazin-4-one
-
50% inhibition at 0.00036 mM
2-(dimethylamino)-7-methyl-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)oxazin-4-one
-
50% inhibition at 0.039 mM
2-(N,N-diethylamino)ethyl phenothiazine carbamate
-
-
2-(N,N-dimethylamino)ethyl phenothiazine carbamate
-
-
2-(trifluoromethyl)phenyl butylcarbamate
-
-
2-amino-3-[2-oxo-2-[phenyl(propan-2-yl)amino]ethyl]-1,3-thiazol-3-ium
-
-
2-amino-7-benzyl-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)oxazin-4-one
-
50% inhibition at 0.0059 mM
2-amino-7-benzyl-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)thiazin-4-one
-
50% inhibition at 0.0012 mM
2-chloro-5-methyl-1,3,2-benzodioxaphosphole 2-oxide
-
50% inhibition at 0.48 mM, detailed kinetic analysis
2-chloro-5-methyl-2,3-dihydro-1H-1,3,2-benzodiazaphosphole 2-oxide
-
50% inhibition at 1.54 mM, detailed kinetic analysis
2-chlorophenyl 1,2-dimethylhydrazinecarboxylate
-
-
2-chlorophenyl 1-methylhydrazinecarboxylate
-
-
2-chlorophenyl butylcarbamate
-
-
2-chlorophenyl phenothiazine carbamate
-
-
2-ethylphenyl butylcarbamate
-
-
2-methoxyphenyl butylcarbamate
-
-
2-methoxyphenyl phenothiazine carbamate
-
-
2-methylphenyl butylcarbamate
-
-
2-methylphenyl phenothiazine carbamate
-
-
2-naphthyl phenothiazine carbamate
-
-
2-nitrophenyl butylcarbamate
-
-
2-t-butylphenyl phenothiazine carbamate
-
-
2-tert-butoxyphenyl butylcarbamate
-
-
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
-
-
2-[(1-[2-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]ethyl]piperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
-
-
2-[(1-[3-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]propyl]piperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
-
-
2-[(2-acetyl-6,6-dimethyl-4-phenyl-5,6-dihydro-2H-1,2-oxazin-3-yl)methyl]-1H-isoindole-1,3(2H)-dione
-
-
-
2-[(E)-(hydroxyimino)methyl]-1-[[(3-nonanoylpyridinium-1-yl)methoxy]methyl]pyridinium diiodide
-
-
2-[(E)-(hydroxyimino)methyl]-1-[[(3-octanoylpyridinium-1-yl)methoxy]methyl]pyridinium diiodide
-
-
2-[(E)-(hydroxyimino)methyl]-1-[[(3-pentanoylpyridinium-1-yl)methoxy]methyl]pyridinium diiodide
-
-
2-[(E)-(hydroxyimino)methyl]-1-[[(3-propanoylpyridinium-1-yl)methoxy]methyl]pyridinium diiodide
-
-
2-[(E)-(hydroxyimino)methyl]-1-[[(3-undecanoylpyridinium-1-yl)methoxy]methyl]pyridinium diiodide
-
-
2-[2-(4-fluorophenyl)-2,3,4,5-tetrahydro-1,5-benzothiazepin-4-yl]phenol
-
2-[2-(4-methylphenyl)-2,3,4,5-tetrahydro-1,5-benzothiazepin-4-yl]phenol
-
2-[4-(1H-benzo[d]imidazol-2-yl)phenoxy]-N,N-diethylethanamine
-
-
-
2-[4-(1H-benzo[d]imidazol-2-yl)phenoxy]-N,N-dimethylethanamine
-
-
-
2-[4-(5(6)-chloro-1H-benzo[d]imidazol-2-yl)phenoxy]-N,N-diethylethanamine
-
-
-
2-[4-(5(6)-chloro-1H-benzo[d]imidazol-2-yl)phenoxy]-N,N-dimethylethanamine
-
-
-
2-[4-[2-(piperidin-1-yl)ethoxy]phenyl]-1H-benzo[d]-imidazole
-
-
-
2-[4-[2-(pyrrolidin-1-yl)ethoxy]phenyl]-1H-benzo[d]-imidazole
-
-
-
2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-N-[3-nitro-5-(pyridin-3-yloxy)phenyl]acetamide
-
-
2-[[(4S)-6,6-dimethyl-4-phenyl-5,6-dihydro-4H-1,2-oxazin-3-yl]methyl]-1H-isoindole-1,3(2H)-dione
-
-
2-[[2-[(5aS,7R,9aS)-1-formyl-7-hydroxy-4-methoxy-6,7-dihydrodibenzo[b,d]furan-9a(5aH)-yl]ethyl](methyl)amino]butanoic acid
-
-
2-[[2-[(5aS,7R,9aS)-7-hydroxy-1-(hydroxymethyl)-4-methoxy-6,7-dihydrodibenzo[b,d]furan-9a(5aH)-yl]ethyl](methyl)amino]butanoic acid
-
-
24-ethyl-cholest-7-ene-3,5,6-triol
-
isolated from Haloxylon recurvum
24-ethylcholest-6-ene-3,5-diol
-
isolated from Haloxylon recurvum
2alpha,11alpha-dihydroxyfawcettiine
-
-
2beta-hydroxyepipachysamine D
-
-
3,3'-((1,5-dioxopentane-1,5-diyl)bis(iminocyclohexane-3,1-diyl))bis(1-methylpyridinium)
-
pKi-values and comparison with inhibitory effect on horse and Berrytheutis magister butyrylcholinesterase EC 3.1.1.8
3,3'-[nonane-1,9-diylbis[(3S)-3-ethylazepane-1,3-diyl]]diphenol
-
binding by a bis-(-)-nor-meptazinol derivative disrupts the catalytic triad, structure analysis and molecular docking, overview
3,3-dimethylbutyl methylphosphonyl thiocholine
-
-
3-((1-benzylpiperidin-4-yl)methoxy)benzaldehyde
-
-
3-(1-benzylpiperidin-4-yloxy)benzaldehyde
-
-
3-(3-((1-benzylpiperidin-4-yl)methoxy)phenyl)-6,7-dimethoxy-4H-chromen-4-one
-
-
3-(3-(1-benzylpiperidin-4-yloxy)phenyl)-6,7-dimethoxy-4H-chromen-4-one
-
-
3-(3-methylphenyl)-2H-chromen-2-one
-
-
3-(4-((1-benzylpiperidin-4-yl)methoxy)phenyl)-6,7-dimethoxy-4H-chromen-4-one
-
-
3-(4-(1-benzylpiperidin-4-yloxy)phenyl)-6,7-dimethoxy-4H-chromen-4-one
-
-
3-(4-methylphenyl)-2H-chromen-2-one
-
-
3-(4-propoxybenzyl)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
-
3-(4-[2-[diethenyl(methylidene)-l5-azanyl]ethoxy]benzyl)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
-
3-(4-[3-[diethenyl(methylidene)-l5-azanyl]propoxy]benzyl)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
-
3-(6-oxo-6-(8-oxooctahydro-2H-2,6-methanopyrido(1,2-a)(1,5)diazocin-3(4H)-yl)hexanoyl)decahydro-8H-1,5-methanopyrido(1,2-a)(1,5)diazocin-8-one
-
pKi-values and comparison with inhibitory effect on horse and Berrytheutis magister butyrylcholinesterase EC 3.1.1.8
3-(9-hydroxy-5,6-dimethyl-7H,9H-pyrano[3,4,5-ij]isoquinolin-9-yl)propane-1,2-diol
-
-
3-(9-methoxy-5,6-dimethyl-7H,9H-pyrano[3,4,5-ij]isoquinolin-9-yl)propane-1,2-diol
-
-
3-(dimethylcarbamoyl)-1-methyl-1,4-dihydroquinolin-5-yl dimethylcarbamate
-
-
3-(dimethylcarbamoyl)-5-[(dimethylcarbamoyl)oxy]-1-methylquinolinium
-
-
3-(N,N-diethylamino)propyl phenothiazine carbamate
-
-
3-(N,N-dimethylamino) phenyl phenothiazine carbamate
-
binding by residues F329 and Y332, structure, overview
3-([7-[methyl(3-[[(methylamino)oxy]carbonyl]benzyl)amino]heptyl]oxy)-9H-xanthen-9-one
-
-
3-benzyl-1-[3-(4-benzylpiperazin-1-yl)propyl]-1,3-dihydro-2H-thieno[2,3-d]imidazol-2-one
-
-
3-carene
-
50% inhibition at 2 mM
3-chlorophenyl 1,2-dimethylhydrazinecarboxylate
-
-
3-chlorophenyl 1-methylhydrazinecarboxylate
-
-
3-chlorophenyl phenothiazine carbamate
-
-
3-ethyl-2-[(1E)-2-(phenylamino)but-1-en-1-yl]naphtho[2,3-d][1,3]oxazol-3-ium
-
-
3-ethyl-2-[(E)-(1-ethyl-6-methoxyquinolin-2(1H)-ylidene)methyl]-5-methoxy-1,3-benzothiazol-3-ium
-
-
3-ethyl-2-[(E)-(1-ethyl-6-methylquinolin-2(1H)-ylidene)methyl]-5-hydroxy-1,3-benzothiazol-3-ium
-
-
3-ethyl-2-[(E)-(1-ethylquinolin-2(1H)-ylidene)methyl]-5-iodo-1,3-benzothiazol-3-ium
-
-
3-hydroxy-2,2,6-trimethyl-3,4,5,6-tetrahydro-2H-pyrano[3,2c] quinoline 5-one
-
isolated from Skimmia laureola
3-methoxy-6-methyl-9H-xanthen-9-one
-
-
3-methoxyphenyl phenothiazine carbamate
-
-
3-methyl-2-(4-methylphenyl)-4H-chromen-4-one
-
-
3-methylphenyl phenothiazine carbamate
-
-
3-N,N-diethylaminophenyl-N'-(1-alkyl) carbamates
-
inhibit quickly by carbamoylation
3-N,N-diethylaminophenyl-N'-(1-butyl) carbamate
-
-
3-N,N-diethylaminophenyl-N'-(1-ethyl) carbamate
-
-
3-N,N-diethylaminophenyl-N'-(1-hexyl) carbamate
-
-
3-N,N-diethylaminophenyl-N'-(1-octyl) carbamate
-
-
3-N,N-diethylaminophenyl-N'-(1-propyl) carbamate
-
-
3-O-acetylhamayne
-
-
3-[10-(benzylmethylamino)decyloxy]xanthen-9-one
-
-
3-[11-(benzylmethylamino)undecyloxy]xanthen-9-one
-
-
3-[12-(benzylmethylamino)dodecyloxy]xanthen-9-one
-
-
3-[3-(benzylmethylamino)propoxy]xanthen-9-one
-
-
3-[3-[(2-methoxybenzyl)methylamino]propoxy]-xanthen-9-one
-
-
3-[4-(benzylmethylamino)butoxy]xanthen-9-one
-
-
3-[4-[3-(diethylamino)propoxy]benzyl]-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
-
3-[5-(4-chlorophenyl)-3,4-dihydro-2H-pyrano[3,2-c]quinolin-9-yl]-N-[4-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]butyl]propanamide
-
-
3-[5-(4-chlorophenyl)-3,4-dihydro-2H-pyrano[3,2-c]quinolin-9-yl]-N-[5-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]pentyl]propanamide
-
-
3-[5-(4-chlorophenyl)-3,4-dihydro-2H-pyrano[3,2-c]quinolin-9-yl]-N-[6-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]hexyl]propanamide
-
-
3-[5-(4-chlorophenyl)-3,4-dihydro-2H-pyrano[3,2-c]quinolin-9-yl]-N-[7-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]heptyl]propanamide
-
-
3-[5-(4-chlorophenyl)-3,4-dihydro-2H-pyrano[3,2-c]quinolin-9-yl]-N-[8-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]octyl]propanamide
-
-
3-[5-(benzylmethylamino)pentyloxy]xanthen-9-one
-
-
3-[6-(benzylmethylamino)hexyloxy]xanthen-9-one
-
-
3-[7-(benzylmethylamino)-heptyloxy]xanthen-9-one
-
-
3-[7-(benzylmethylamino)heptyloxy]-6-methoxyxanthen-9-one
-
-
3-[7-[(2,3-dimethoxybenzyl)methylamino]heptyloxy]xanthen-9-one
-
-
3-[7-[(2,5-dimethoxybenzyl)methylamino]heptyloxy]xanthen-9-one
-
-
3-[7-[(2-chlorobenzyl)methylamino]-heptyloxy]-xanthen-9-one
-
-
3-[7-[(2-methoxybenzyl)methylamino]heptyloxy]-xanthen-9-one
-
-
3-[7-[(3-chlorobenzyl)methylamino]-heptyloxy]-xanthen-9-one
-
-
3-[7-[(3-methoxybenzyl)methylamino]heptyloxy]-xanthen-9-one
-
-
3-[7-[(4-chlorobenzyl)methylamino]-heptyloxy]-xanthen-9-one
-
-
3-[7-[(4-methoxybenzyl)methylamino]heptyloxy]-xanthen-9-one
-
-
3-[7-[ethyl-(2-methoxybenzyl)amino]heptyloxy]-xanthen-9-one
-
-
3-[7-[methyl-(2,3,4-trimethoxybenzyl)amino]-heptyloxy]xanthen-9-one
-
-
3-[7-[methyl-(2-methylbenzyl)amino]-heptyloxy]-xanthen-9-one
-
-
3-[7-[methyl-(2-nitrobenzyl)amino]heptyloxy]-xanthen-9-one
-
-
3-[8-(benzylmethylamino)octyloxy]xanthen-9-one
-
-
3-[9-(benzylmethylamino)nonyloxy]xanthen-9-one
-
-
3-[omega-(benzylmethylamino)alkoxy]xanthen-9-ones
-
structure-activity relationships, overview
3a-methyl-2,3,3a,8a-tetrahydrofuro(2,3-b)(1)benzofuran-5-yl (2-methylphenyl)carbamate
-
50% inhibition at 23 nM
3a-methyl-2,3,3a,8a-tetrahydrofuro(2,3-b)(1)benzofuran-5-yl (4-isopropylphenyl)carbamate
-
50% inhibition at 2650 nM
3a-methyl-2,3,3a,8a-tetrahydrofuro(2,3-b)(1)benzofuran-5-yl ethylcarbamate
-
50% inhibition at 360 nM
4,4'-(3-oxo-1,5-pentanediyl)bis(N-allyl-N,N-dimethylanilinium) dibromide
-
BW284c51
4,5-diethyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
-
4-((1-benzylpiperidin-4-yl)methoxy)benzaldehyde
-
-
4-(1-benzylpiperidin-4-yloxy)benzaldehyde
-
-
4-(1H-benzimidazol-2-yl)phenol
-
-
4-(5-chloro-1H-benzimidazol-2-yl)phenol
-
-
4-(5-methyl-1H-benzimidazol-2-yl)phenol
-
-
4-(aminocarbonyl)-1-(((2-((Z)-(hydroxyimino)methyl)pyridinium-1-yl)methoxy)methyl)pyridinium dichloride
-
i.e. HI-6, reversible, detailed kinetic analysis
4-biphenyl phenothiazine carbamate
-
-
4-bromo-N-[di(morpholin-4-yl)phosphoryl]benzamide
-
-
4-chloro-N-[di(morpholin-4-yl)phosphoryl]benzamide
-
-
4-chlorophenyl 1,2-dimethylhydrazinecarboxylate
-
-
4-chlorophenyl 1-methylhydrazinecarboxylate
-
-
4-chlorophenyl phenothiazine carbamate
-
-
4-cymene
-
isolated from Melaleuca atlernifolia
4-ethenyl-5-ethyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
-
4-ethenyl-5-hexyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
-
4-ethenyl-5-methyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
-
4-ethenyl-5-pentyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
-
4-ethenyl-5-propyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
-
4-ethyl-5-hexyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine hydrobromide
-
-
4-ethyl-5-methyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
-
4-ethyl-5-pentyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
-
4-ethyl-5-propyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
-
4-ethyl-N-methyl-dihydrophenanthridine
-
-
4-ketoamyl trimethyl ammonium iodide
-
nonhydrolysable substrate analogue, mechanism of substrate inhibition
4-ketoamyltrimethylammonium
-
binding structure analysis
4-methoxyphenyl phenothiazine carbamate
-
-
4-methylphenyl phenothiazine carbamate
-
-
4-nitrophenyl allylcarbamate
-
detailed kinetic analysis and mechanism
4-nitrophenyl benzylcarbamate
-
detailed kinetic analysis and mechanism
4-nitrophenyl butylcarbamate
-
detailed kinetic analysis and mechanism
4-nitrophenyl hexylcarbamate
-
detailed kinetic analysis and mechanism
4-nitrophenyl octylcarbamate
-
detailed kinetic analysis and mechanism
4-nitrophenyl phenylcarbamate
-
detailed kinetic analysis and mechanism
4-nitrophenyl tert-butylcarbamate
-
detailed kinetic analysis and mechanism
4-O-methylhonokiol
-
isolated from ethanol extract of Magnolia officinalis. 4-O-methylhonokiol also dose-dependently attenuates the scopolamine-induced increase of AChE activity in the cortex and hippocampus of mice
4-oxo-N,N,N-trimethylpentanaminium iodide
-
i.e. OTMA, a hydrolysable substrate analogue, binding structure analysis
4-t-butylphenyl phenothiazine carbamate
-
-
4-[2-[4-(1H-benzo[d]imidazol-2-yl)phenoxy]ethyl]morpholine
-
-
-
4-[2-[4-(5(6)-chloro-1H-benzo[d]imidazol-2-yl)phenoxy]ethyl]morpholine
-
-
-
4-[2-[4-(5(6)-methyl-1H-benzo[d]imidazol-2-yl)phenoxy]ethyl]morpholine
-
-
-
4-[4-(4-benzylpiperazin-1-yl)butyl]pyrrolo[1,2-a]thieno[2,3-e]pyrazin-5(4H)-one
-
-
4-[4-(4-benzylpiperazin-1-yl)butyl]pyrrolo[1,2-a]thieno[3,2-e]pyrazin-5(4H)-one
-
-
5(6)-chloro-2-[4-[2-(piperidin-1-yl)ethoxy]phenyl]-1H-benzo[d]imidazole
-
-
-
5(6)-chloro-2-[4-[2-(pyrrolidin-1-yl)ethoxy]phenyl]-1H-benzo[d]imidazole
-
-
-
5(6)-methyl-2-[4-[2-(piperidin-1-yl)ethoxy]phenyl]-1H-benzo[d]imidazole
-
-
-
5(6)-methyl-2-[4-[2-(pyrrolidin-1-yl)ethoxy]phenyl]-1H-benzo[d]imidazole
-
-
-
5,5'-dithiobis(2-nitrobenzoic acid)
inactivation, the peripheral site ligand propidium accelerates inactivation in the wild type ChE2, but retards inactivation in the F312I mutant
5,6-dimethoxy-2-(3-(2-(piperidin-1-yl)ethyl)phenoxy)-indan-1-one
-
-
5,6-dimethoxy-2-(3-(2-(pyrrolidin-1-yl)ethyl)phenoxy)-indan-1-one
-
-
5,6-dimethoxy-2-(3-(3-(pyrrolidin-1-yl)propanoyl)phenoxy)-indan-1-one
-
-
5,6-dimethoxy-2-(4-(2-(piperidin-1-yl)acetyl)phenoxy)-indan-1-one
-
-
5,6-dimethoxy-2-(4-(2-(piperidin-1-yl)ethyl)phenoxy)-indan-1-one
-
-
5,6-dimethoxy-2-(4-(2-(pyrrolidin-1-yl)acetyl)phenoxy)-indan-1-one
-
-
5,6-dimethoxy-2-(4-(2-(pyrrolidin-1-yl)ethyl)phenoxy)-indan-1-one
-
-
5,6-dimethoxy-2-(4-(3-(piperidin-1-yl)propanoyl)phenoxy)-indan-1-one
-
-
5,6-dimethoxy-2-(4-(3-(piperidin-1-yl)propyl)phenoxy)-indan-1-one
-
-
5,6-dimethoxy-2-(4-(3-(pyrrolidin-1-yl)propanoyl)phenoxy)-indan-1-one
-
-
5,6-dimethoxy-2-(4-(3-(pyrrolidin-1-yl)propyl)phenoxy)-indan-1-one
-
-
5,6-dimethoxy-2-(4-(4-(piperidin-1-yl)butanoyl)phenoxy)-indan-1-one
-
-
5,6-dimethoxy-2-(4-(4-(pyrrolidin-1-yl)butanoyl)phenoxy)-indan-1-one
-
-
5,6-dimethoxy-2-(4-(4-(pyrrolidin-1-yl)butyl)phenoxy)-indan-1-one
-
-
5,6-dimethoxy-2-([1-[2-(1,2,3,4-tetrahydroacridin-9-ylamino)ethyl]piperidin-4-yl]methyl)-2,3-dihydro-1H-inden-1-one
-
-
5,6-dimethoxy-2-([1-[3-(1,2,3,4-tetrahydroacridin-9-ylamino)propyl]piperidin-4-yl]methyl)-2,3-dihydro-1H-inden-1-one
-
-
5,6-dimethoxy-9-prop-2-en-1-yl-7H,9H-pyrano[3,4,5-ij]isoquinolin-9-ol
-
-
5,7,8,13-tetrahydroindolo [2',3':3,4]pyrido[2,1-b]quinazoline
-
-
5,8-dihydro-6H isoquino[1,2b]quinazoline
-
-
5-(4-chlorophenyl)-N-[10-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]decyl]-3,4-dihydro-2H-pyrano[3,2-c]quinoline-9-carboxamide
-
-
5-(4-chlorophenyl)-N-[6-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]hexyl]-3,4-dihydro-2H-pyrano[3,2-c]quinoline-9-carboxamide
-
-
5-(4-chlorophenyl)-N-[7-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]heptyl]-3,4-dihydro-2H-pyrano[3,2-c]quinoline-9-carboxamide
-
-
5-(4-chlorophenyl)-N-[8-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]octyl]-3,4-dihydro-2H-pyrano[3,2-c]quinoline-9-carboxamide
-
-
5-(4-chlorophenyl)-N-[9-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]nonyl]-3,4-dihydro-2H-pyrano[3,2-c]quinoline-9-carboxamide
-
-
5-(4-chlorophenyl)-N-[9-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]nonyl]-3,4-dihydro-2H-pyrano[3,2-c]quinoline-9-carboxamide
-
-
5-amino-2-methyl-6,7,8,9-tetrahydrobenzo[b][1,8]naphthyridine-3-carboxylate
-
-
5-butyl-4-ethenyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
-
5-butyl-4-ethyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
-
5-hydroxy-5,6-seco-dihydrolycorine
-
-
5-hydroxy-5,6-secolycorine
-
-
5-[(1-benzylpiperidin-4-yl)methoxy]-1-methylpyrrolo[1,2-a]thieno[2,3-e]pyrazine
-
-
5-[(1-benzylpiperidin-4-yl)methoxy]pyrrolo[1,2-a]thieno[3,2-e]pyrazine
-
-
5-[(dimethylcarbamoyl)oxy]-1-methyl-3-(methylcarbamoyl)quinolinium
-
-
5-[(dimethylcarbamoyl)oxy]-1-methyl-3-(morpholin-4-ylcarbonyl)quinolinium
-
-
5-[(dimethylcarbamoyl)oxy]-3-(ethoxycarbonyl)-1-methylquinolinium
-
-
5-[(dimethylcarbamoyl)oxy]-3-(methoxycarbonyl)-1-methylquinolinium
-
-
5-[(E)-(dimethylhydrazinylidene)methyl]-1-(4-methoxy-3-nitrobenzyl)-1H-imidazole
-
-
5-[(ethylcarbamoyl)oxy]-3-(methoxycarbonyl)-1-methylquinolinium
-
-
5-[4-(4-benzylpiperazin-1-yl)butyl]-7-phenyl-1,5-dihydro-4H-furo[2,3-b]pyrrolo[2,3-d]pyridin-4-one
-
-
5alpha,8alpha-epidioxy-(24S)-ethylcholesta-6,9(11),22(E)-triene-3beta-ol
-
isolated from Haloxylon recurvum
6,7-dimethoxy-2-(3-methylphenyl)-4H-chromen-4-one
-
-
6,7-dimethoxy-3-(3-methylphenyl)-2H-chromen-2-one
-
-
6,7-dimethoxy-3-(4-methylphenyl)-2H-chromen-2-one
-
-
6-chloro-N-(2-[4-[(5,6-dimethoxy-2,3-dihydro-1H-inden-2-yl)methyl]piperidin-1-yl]ethyl)-1,2,3,4-tetrahydroacridin-9-amine
-
-
6-chloro-N-(3-[4-[(5,6-dimethoxy-2,3-dihydro-1H-inden-2-yl)methyl]piperidin-1-yl]propyl)-1,2,3,4-tetrahydroacridin-9-amine
-
-
6-chlorotacrine
-
-
6-hydroxycrinamine
-
-
6-methoxy-2-(3-methylphenyl)-4H-chromen-4-one
-
-
6-methoxy-2-(4-methylphenyl)-4H-chromen-4-one
-
-
6-methoxy-3-(3-methylphenyl)-2H-chromen-2-one
-
-
6-methoxy-3-(4-methylphenyl)-2H-chromen-2-one
-
-
6-methoxytacrine
-
mixed competitive-uncompetitive inhibition
-
6-O-demethylgalanthamine
-
-
6-[7-(benzylmethylamino)heptyloxy]-2,3-dimethoxyxanthen-9-one
-
-
6beta,8alpha-diacetoxy-9beta-furoyloxy-1alpha-hydroxy-beta-agarofuran
-
-
7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinoline
-
-
7-benzoyl-2-(dimethylamino)-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)oxazin-4-one
-
50% inhibition at 0.036 mM
7-benzyl-2-((3,4-dimethoxybenzyl)(methyl)amino)-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)oxazin-4-one
-
50% inhibition at 0.00033 mM
7-benzyl-2-(4-benzylpiperazin-1-yl)-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)oxazin-4-one
-
50% inhibition at 0.00132 mM
7-benzyl-2-(benzyl(methyl)amino)-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)oxazin-4-one
-
50% inhibition at 0.00084 mM
7-benzyl-2-(benzylamino)-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)oxazin-4-one
-
50% inhibition at 0.00286 mM
7-benzyl-2-(benzylamino)-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)thiazin-4-one
-
50% inhibition at 0.0052 mM
7-benzyl-2-(cyclohexylamino)-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)thiazin-4-one
-
50% inhibition at 0.00282 mM
7-benzyl-2-(diethylamino)-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)oxazin-4-one
-
50% inhibition at 0.00208 mM
7-benzyl-2-(dimethylamino)-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)oxazin-4-one
-
50% inhibition at 0.00089 mM
7-benzyl-2-(isopropylamino)-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)oxazin-4-one
-
50% inhibition at 0.00074 mM
7-benzyl-2-(isopropylamino)-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)thiazin-4-one
-
50% inhibition at 0.00058 mM
7-benzyl-2-(phenylamino)-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)oxazin-4-one
-
50% inhibition at 0.00094 mM
7-benzyl-2-(phenylamino)-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)thiazin-4-one
-
50% inhibition at 0.00103 mM
7-benzyl-2-(propan-2-ylamino)-1,2,5,6,7,8-hexahydro-4H-pyrido[4',3':4,5]thieno[2,3-d][1,3]thiazin-4-one
-
the substance acts as a hyperbolic mixed-type inhibitor
7-benzyl-2-morpholin-4-yl-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)oxazin-4-one
-
50% inhibition at 0.00077 mM
7-bromo-6-methyl-7H,9H-pyrano[3,4,5-ij]isoquinolin-9-one
-
-
7-deoxy-trans-dihydronarciclasine
-
-
7-methoxy-2-(3-methylphenyl)-4H-chromen-4-one
-
-
7-methoxy-2-(4-methylphenyl)-4H-chromen-4-one
-
-
7-methoxy-3-(3-methylphenyl)-2H-chromen-2-one
-
-
7-methoxy-3-(4-methylphenyl)-2H-chromen-2-one
-
-
7-methyloctahydro-2H-quinolizin-1-yl (7-methyloctahydro-2H-quinolizin-1-yl)methyl butanedioate
-
pKi-values and comparison with inhibitory effect on horse and Berrytheutis magister butyrylcholinesterase EC 3.1.1.8
7-[(dimethylcarbamoyl)oxy]-3-(ethoxycarbonyl)-1-methylquinolinium
-
-
8-alpha-ethoxyprecriwelline
-
-
8-demethoxy-10-O-methylhostasine
-
a benzylphenethylamine alkaloid from Hosta plantaginea
8-demethoxyhostasine
-
benzylphenethylamine alkaloid from Hosta plantaginea
8-methoxyflindersine
-
an alkaloid isolated from Waltheria brachypetala
9,10-dimethoxy-1,2,3,12,15,16-hexadehydrogalanthan
-
-
9-(2-oxo-3-pyrrolidin-1-ylpropyl)-7H-dibenzo[de,h]quinolin-7-one
-
-
9-(2-oxo-4-pyrrolidin-1-ylbutyl)-7H-dibenzo[de,h]quinolin-7-one
-
-
9-(2-oxo-5-pyrrolidin-1-ylpentyl)-7H-dibenzo[de,h]quinolin-7-one
-
-
9-(3-bromo-5-ethoxy-4-hydroxyphenyl)-3,3,6,6-tetramethyl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione
-
-
9-(4-[[2-(dimethylamino)ethyl]amino]-2-oxobutyl)-7H-dibenzo[de,h]quinolin-7-one
-
-
9-amino-1,2,3,4-tetrahydroacridin-1-ol
-
-
9-amino-1,2,3,4-tetrahydroacridin-1-ol
-
9-aminoacridine
-
-
9-aminoacridine
-
9-O-demethyl-7-O-methyllycorenine
-
a benzylphenethylamine alkaloid from Hosta plantaginea
9-O-[2-(9H-carbazole-4-yloxy)ethyl] berberine bromide
-
-
9-O-[2-(benzotriazole-1-yloxy)ethyl] berberine bromide
-
-
9-O-[2-(phenylol-1-yloxy)ethyl] berberine bromide
-
-
9-O-[2-(phenylol-1-yloxy)hexyl] berberine bromide
-
-
9-O-[3-(9H-carbazole-4-yloxy)propyl] berberine bromide
-
-
9-O-[3-(benzotriazole-1-yloxy)propyl] berberine bromide
-
-
9-O-[3-(phenylol-1-yloxy)propyl] berberine bromide
-
-
9-O-[4-(9H-carbazole-4-yloxy)butyl] berberine bromide
-
-
9-O-[4-(benzotriazole-1-yloxy)butyl] berberine bromide
-
-
9-O-[4-(phenylol-1-yloxy)butyl] berberine bromide
-
most potent berberine derivative inhibitor, mixed type inhibition
9-O-[5-(9H-carbazole-4-yloxy)butyl] berberine bromide
-
-
9-O-[5-(benzotriazole-1-yloxy)pentyl] berberine bromide
-
-
9-O-[5-(phenylol-1-yloxy)pentyl] berberine bromide
-
-
9-O-[6-(9H-carbazole-4-yloxy)butyl] berberine bromide
-
-
9-O-[6-(benzotriazole-1-yloxy)hexyl] berberine bromide
-
-
9-[3-(dimethylamino)-2-oxopropyl]-7H-dibenzo[de,h]quinolin-7-one
-
-
9-[4-(diethylamino)-2-oxobutyl]-7H-dibenzo[de,h]quinolin-7-one
-
-
9-[4-(dimethylamino)-2-oxobutyl]-7H-dibenzo[de,h]quinolin-7-one
-
-
9-[4-[(2-hydroxyethyl)amino]-2-oxobutyl]-7H-dibenzo[de,h]quinolin-7-one
-
-
9-[5-(dimethylamino)-2-oxopentyl]-7H-dibenzo[de,h]quinolin-7-one
-
-
acetaldehyde
-
acetonitrile
-
a competitive pseudo-inhibition is observed for 6% acetonitrile
acetyl-[beta-methyl]thiocholine
-
-
Acetylcholine
-
-
Acetylcholine
-
-
Acetylcholine
-
above 2.5 mM
Acetylcholine
-
substrate inhibition
Acetylcholine
-
substrate inhibition above 1 mM
Acetylcholine
-
substrate inhibition above 1 mM, less pronounced than in Pseudorasbora parva or Carassius auratus auratus
Acetylcholine
-
substrate inhibition above 1 mM
Acetylcholine
-
mechanism of substrate inhibition
Acetylcholine
-
substrate inhibition due to choline exit being hindered by a substrate molecule bound at the peripheral site
acetylcholine iodide
-
substrate inhibition above 4 mM
acetylthiocholine
-
-
acetylthiocholine
-
substrate inhibition above 1 mM
acetylthiocholine
-
substrate activitation at low concentrations, substrate inhibition at high concentrations
acetylthiocholine
-
-
acetylthiocholine
-
substrate inhibition above 2.56 mM
acetylthiocholine
Nephotettix cincticeps Uhler
-
N-methyl carbamate-resistant strain, no substrate inhibition up to 0.01 mM
acetylthiocholine
-
interaction with Glu199 of ATCh, substrate inhibition due to choline exit being hindered by a substrate molecule bound at the peripheral site
acetylthiocholine
-
substrate inhibition
acetylthiocholine
the recombinant carp AChE shows substrate inhibition at high substrate concentrations of acetyl- and propionylthiocholine
acetylthiocholine
-
substrate inhibition
acetylthiocholine iodide
-
above 5 mM
acetylthiocholine iodide
-
above 5 mM
acetylthiocholine iodide
-
acrifoline
-
isolated from ethanolic extracts of Lycopodium annotinum ssp. alpestre
AF-DX 384
-
-
aflatoxin
-
-
aflatoxin B1
-
50% inhibition at 0.031 mM by increase of Km-value and decrease of vmax-value. Partial recativation by 2-aldoxime, i.e. 2-PAM, pyridin-2-aldoxime 1-methoiodide
aldicarb-sulfone
-
-
aldicarb-sulfone
-
aldicarb-sulfoxide
-
-
aldicarb-sulfoxide
-
alpha-amyrin
-
a pentacyclic triterpene, isolated the ethanolic extract of Chuquiraga erinacea D. Don. subsp. erinacea leaves as a mixture of alpha- and beta amyrin
alpha-pinene
-
IC50 is 0.022 mg/ml
alpha-terpinen
-
isolated from Melaleuca atlernifolia
alpha-terpineol
-
IC50 is 1.3 mg/ml
amlodipine besylate
-
reversible mixed-type inhibition
amlodipine besylate
-
-
anhydrolycodoline
-
isolated from ethanolic extracts of Lycopodium annotinum ssp. alpestre
annotine
-
isolated from ethanolic extracts of Lycopodium annotinum ssp. alpestre
annotine N-oxide
-
isolated from ethanolic extracts of Lycopodium annotinum ssp. alpestre
annotinine
-
isolated from ethanolic extracts of Lycopodium annotinum ssp. alpestre
AP2238
-
-
Aspartame
-
and its metabolites, inhibitory above 2.8 mg per kg body weight
assoanine
-
-
atricarpan A
-
-
atricarpan B
-
-
atricarpan C
-
-
atricarpan D
-
-
axillaridine A
-
-
axillarine C
-
-
axillarine F
-
-
azamethiphos
insecticide
azamethiphos
-
50% inhibition at 0.1 mM, 80% inhibition after 60 min at 0.003 mM
azamethiphos
-
bambuterol
-
50% inhibition at 0.03 mM
bambuterol
-
a specific and stereoselective inhibitor of butyrylcholinesterase, which is about 8000times faster inhibted than acetylcholinesterase. AChE wild-type enzyme, and mutants F297I/Y337A and F295L/F297I/Y337A show a deviation from linearity, either enzymes are inhibited by racemate or enantiomers, indicating the presence of reversible enzyme-inhibitor complex, overview
batimastat
-
-
bendiocarb
insecticide
benzoyl phosphoramidic dichloride
-
-
benzoylphosphoramidic dichloride
-
-
benzyl alcohol
-
-
Berberine
-
competitive inhibition
beta-amyrin
-
a pentacyclic triterpene, isolated the ethanolic extract of Chuquiraga erinacea D. Don. subsp. erinacea leaves as a mixture of alpha- and beta amyrin
biphenyl-2-yl butylcarbamate
-
-
bis-N,N-dimethylfulleropyrrolidinium salts
-
inhibitory activity and mechanism of cationic fulleropyrrolidinium regioisomers, AChE docking parameters, molecular modleing, overview
-
bisnorcymserine
-
50% inhibition at mM
bisnorcymserine
-
-
bromchlophos
-
bulbocapnine
-
isolated from Corydalis cava
butocarboxim
-
butoxycarboxim
-
-
butoxycarboxim
-
butyl carbamate
-
-
butylsarin
-
detailed analysis of inhibition kinetics
butyrylthiocholine
Nephotettix cincticeps Uhler
-
N-methyl carbamate-resistant strain, no substrate inhibition up to 0.01 mM
butyrylthiocholine
-
butyrylthiocholine iodide
-
buxabenzacinine
-
isolated from Buxus hyrcana
buxamine-B
-
50% inhibition at 0.074 mM, noncompetitive
buxamine-C
-
50% inhibition at 0.0075 mM, noncompetitive
buxandrine
-
isolated from Buxus hyrcana
buxidin
-
isolated from Buxus hyrcana
buxippine-K
-
isolated from Buxus hyrcana
buxoviricine
-
isolated from Buxus hyrcana
BW 284C51
-
50% inhibition at 0.0063 mM
BW248c51
-
i.e. 1,5-bis(4-allyldimethyl-ammoniumphenyl)pentane-3-one dibromide, specific inhibition of AChE
BW284C5
-
i.e. 1,5-bis(4-allyldimethylammoniumphenyl)pentan-3-one dibromide, complete inhibition at 1 mM
-
BW284c51
-
0.01 mM, more than 97% inhibition
BW284c51
-
-strong
BW284c51
50% inhibition at 0.0025 mM
BW284c51
50% inhibition at 0.002 mM
BW284c51
50% inhibition at 0.0022 mM
BW284c51
-
0.001 mM, almost complete inhibition
BW284c51
-
50% inhibition at 0.000021 mM
BW284c51
-
specific inhibition of acetylthiocholinesterase activity
BW284c51
-
isozyme AChE1A, complete competitive inhibition at 0.016 mM
BW284c51
-
selective inhibitor
BW284c51
-
a reversible elongated gorge-spanning inhibitor, which bridges the two sites, the anionic subsite at the bottom of the active-site gorge and the peripheral anionic site at the entrance to the gorge
BW284c51
-
-
BW284c51
-
complete inhibition at 0.1 mM
BW284c51
-
i.e. 1,5-bis(4-allyldimethylammoniumphenyl)pentan-3-one dibromide
BW284c51
-
highly sensitive to inhibition by BW284C51
BW284c51
-
-
BW4c51
-
-
-
BW4c51
-
-
-
BW4c51
-
-
-
calenduladiol
-
a pentacyclic triterpene, isolated the ethanolic extract of Chuquiraga erinacea D. Don. subsp. erinacea leaves. 31.2% inhibition at 0.5 mM
carbanolate
-
Carbaryl
-
-
Carbaryl
-
-
Carbaryl
-
i.e. Ziofil 5, a pesticide, in vivo and in vitro inhibition, 85% inhibition at 0.001 mM, clearing within 5 days, overview
Carbaryl
-
-
Carbaryl
i.e. N-methyl-1-naphthylcarbamate, complete inhibition at concentrations exceeding 100 nM; i.e. N-methyl-1-naphthylcarbamate, complete inhibition at concentrations exceeding 100 nM
Carbaryl
-
-
carbofuran
-
-
carbofuran
-
-
carbofuran
-
-
carbofuran
-
-
carbosulfan
-
50% inhibition at 0.717 nM
carbosulfan
-
50% inhibition at 0.836 nM
carinatumin A
-
-
carvacrol
-
in vitro inhibition, compound of the essential oil of Thymus vulgaris
carvacrol
-
isolated from Thymus vulgaris essential oil
chitooligosaccharides
-
90-COSs and 50-COSs are prepared from 90% and 50% deacetylated chitosan, cellular AChE activity is decreased with increasing concentration of 90-MMWCOS chitooligosaccharides in PC12 cell lines, the 90-COSs exhibit more potent AChE inhibitory activities compared to 50-COSs, while 90-MMWCOS, 1-5 kDa, in the 90COSs show the highest activity, overview
chlordiazepoxide HCl
-
reversible mixed-type inhibition
chlordiazepoxide HCl
-
-
chlorfenvinphos
-
-
chlorfenvinphos
-
Chloroquine
-
mixed type, 33% inhibition at 0.022 mM, 67% inhibition at 0.193 mM
chlorpyrifos
-
strong inhibition, used for active site titration
chlorpyrifos
-
a widely used organophosphorous pesticide, complete inhibition at 0.1 mM
chlorpyrifos
-
-
chlorpyrifos
-
-
chlorpyrifos
-
-
chlorpyrifos oxon
-
-
chlorpyrifos oxon
-
enzyme from Huanghua population is 62fold less sensitive than from Pingshan population
chlorpyrifos oxon
-
-
chlorpyrifos oxon
-
i.e. (O,O-diethyl O-(3,5,6-trichloro-2-pyridyl)) phosphate, an organophosphate
chlorpyrifos oxon
-
-
chlorpyrifos-oxon
-
complete inhibition of wild-type enzyme
choline
-
-
choline
-
product inhibition, binding structure analysis
choline
-
product inhibition
choline
-
the activity decreases to 40% at 200 mM
cis-rosmarinic acid
-
from extracts of Melissa officinalis leaves
conarrhimin
-
strong inhibition, 94% inhibition at 0.1 mg/ml
-
conessimin
-
strong, reversible and noncompetitive inhibition, 98% inhibition at 0.1 mg/ml
-
conessine
-
strong inhibition, 95% inhibition at 0.1 mg/ml
-
conimin
-
strong inhibition, 96% inhibition at 0.1 mg/ml
-
coryldammine
-
-
coumaphos-oxon
-
-
coumaphos-oxon
-
coumarin 106
-
exhibits mixed-type AChE inhibition, targets a primary binding site at the active gorge and a secondary peripheral anionic binding site. Analysis of inhibitor binding, overview
Crotoxyphos
-
cryptotanshinone
-
mixed non-competitive inhibitor
cycloheptyl methylphosphonyl thiocholine
-
SP and RP enantiomers
cyclopentyl phenothiazine carbamate
-
-
cyclophostin
-
a natural AChE inhibitor
cyclosarin
-
detailed analysis of inhibition kinetics
cyclosarin
-
reactivation of sarin-inhibited acetylcholinesterase by oximes, 2-PAM, MMB4, HI-6, HLo-7, and ICD-585, overview
cyclosarin
-
a methylfluorophosphonate, enzyme reactivation by oximes, overview
cyclosarin
-
a nerve agent
cyclosarin
-
-
cymserine
-
inhibition in the nanomolar range
dec-N-dimethylregeline
-
-
decamethonium
-
a reversible elongated gorge-spanning inhibitor, which bridges the two sites, the anionic subsite at the bottom of the active-site gorge and the peripheral anionic site at the entrance to the gorge
dehydroevodiamine hydrochloride
-
isolated from Evodia rutaecarpa
demeton
-
complete inhibition of wild-type enzyme
demeton-S-methyl
-
enzyme from Huanghua population is 2fold less sensitive than from Pingshan population
demeton-S-methyl
-
-
demeton-S-methyl
-
diazepam
-
reversible mixed-type inhibition
diazinon
-
-
diazoxon
-
second order rate constant for inhibition is 420000 per M and min
dichlorvos
insecticide
dichlorvos
50% inhibition at 0.00059 mM
dichlorvos
50% inhibition at 0.00058 mM
dichlorvos
50% inhibition at 0.00056 mM
dichlorvos
-
irreversible inhibition
dichlorvos
-
in vivo inhibition in the brain, overview
dichlorvos
-
-
dichlorvos
-
-
dichlorvos
-
-
dicrotophos
-
diethyl (2S)-2-((2-oxido-1,3,2-benzodioxaphosphol-2-yl)amino)pentanedioate
-
50% inhibition at 0.454 mM
diethyl (2S)-2-((2-oxido-1,3,2-benzodioxaphosphol-2-yl)amino)pentanedioate
-
50% inhibition at 1.226 mM
diethyl (2S)-2-((2-oxido-1,3,2-benzodioxaphosphol-2-yl)amino)succinate
-
50% inhibition at 0.651 mM
diethyl (2S)-2-((2-oxido-1,3,2-benzodioxaphosphol-2-yl)amino)succinate
-
50% inhibition at 0.577 mM
diethylfluorophosphate
-
-
diethyltabun
-
detailed analysis of inhibition kinetics
dihydrotanshinone
-
mixed non-competitive inhibitor
diisopropyl fluorophosphate
-
nerve agent, binding structure, overview
diisopropyl phosphofluoridate
-
complete inhibition of wild-type enzyme, not of mutant G122H/Y124Q/S125T
diisopropyl phosphorofluoridate
-
-
diisopropyl phosphorofluoridate
-
synthesis and evaluation of novel bis-pyridinium oximes as reactivators of DFP-inhibited acetylcholinesterase, overview. 1,3-Dimethoxymethyl benzene bis-[4,40-(hydroxyiminomethyl) pyridinium] dichloride and 1,4-dimethoxy but-2-ene bis-[4,40-(hydroxyiminomethyl) pyridinium] dichloride show high efficacy
diisopropylfluorophosphate
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diisopropylfluorophosphate
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diisopropylfluorophosphate
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diisopropylfluorophosphate
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diisopropylfluorophosphate
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detailed analysis of inhibition kinetics
diisopropylfluorophosphate
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diisopropylfluorophosphate
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Dimethoate
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Dimethoate
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affects the Km of the enzyme
dimethyl (2-acetyl-6,6-dimethyl-4-phenyl-5,6-dihydro-2H-1,2-oxazin-3-yl)propanedioate
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dimethyl [(10R)-10-(4-methoxyphenyl)-7-oxa-8-azaspiro[4.5]dec-8-en-9-yl]propanedioate
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dimethyl [(1S,4S,4'R)-4'-phenyl-4'H-spiro[bicyclo[2.1.1]hexane-5,5'-[1,2]oxazin]-3'-yl]propanedioate
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dimethyl [(4R)-4,6,6-trimethyl-5,6-dihydro-4H-1,2-oxazin-3-yl]