Information on EC 3.1.1.7 - acetylcholinesterase

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The expected taxonomic range for this enzyme is: Eukaryota

EC NUMBER
COMMENTARY
3.1.1.7
-
RECOMMENDED NAME
GeneOntology No.
acetylcholinesterase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
acetylcholine + H2O = choline + acetate
show the reaction diagram
-
-
-
-
acetylcholine + H2O = choline + acetate
show the reaction diagram
mechanism
-
acetylcholine + H2O = choline + acetate
show the reaction diagram
mechanism
-
acetylcholine + H2O = choline + acetate
show the reaction diagram
mathematical modelling of mechanism
-
acetylcholine + H2O = choline + acetate
show the reaction diagram
computer-modelled comparison of ordered uni bi and ki kinetic mechanism. ki model is accurate at equilibrium and when the inhibitor concentration is well below its Kd value
-
acetylcholine + H2O = choline + acetate
show the reaction diagram
formation of the trigonal bipyramidal transition state
-
acetylcholine + H2O = choline + acetate
show the reaction diagram
reaction mechanism, structure-function relationship analysis, binding structure and mechanism of substrate and product at both the peripheral and active sites, overview
-
acetylcholine + H2O = choline + acetate
show the reaction diagram
reaction mechanism, active site structure, the catalytic triad comprises the residues Ser203, His447, Glu334, residues Ser203 and His447 are directly involved in the reaction, serving as nucleophilic attacking group and general acid base catalytic elements, respectively, at the acylation stage of the enzymatic reaction. Modern molecular modeling using tools including molecular docking, molecular dynamics (MD), quantum chemistry and the combined quantum mechanical-molecular mechanical method, overview
-
acetylcholine + H2O = choline + acetate
show the reaction diagram
the mechanism for AChE-catalyzed hydrolysis of substrate is formation of the first tetrahedral intermediate via nucleophilic attack of the active site serine
-
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
hydrolysis of carboxylic ester
-
-
-
-
transacetylation
-
-
-
-
PATHWAY
KEGG Link
MetaCyc Link
Glycerophospholipid metabolism
-
SYSTEMATIC NAME
IUBMB Comments
acetylcholine acetylhydrolase
Acts on a variety of acetic esters; also catalyses transacetylations.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
AcCholE
-
-
-
-
ACE-1
-
gene name
acetyl beta-methylcholinesterase
-
-
-
-
acetyl cholinesterase
-
-
acetylcholine acetylhydrolase
-
-
acetylcholine esterase
-
-
-
-
acetylcholine hydrolase
-
-
-
-
acetylcholinesterase
-
-
acetylcholinesterase
-
-
acetylcholinesterase
-
-
acetylcholinesterase
-
-
acetylcholinesterase 1
-
-
acetylcholinesterase 1
-
-
acetylcholinesterase 2
-
-
acetylcholinesterase-1
-
-
acetylthiocholinesterase
-
-
-
-
AChE
-
-
-
-
AChE
-
-
AChE
Cimex lectularius Bedbug
-
-
-
AChE
B7X755
-
AChE
P22303
-
AChE
Hydra magnipapillata 105
-
-
-
AChE
D2KX94
-
AChE
P91954
-
AChE
P21836
-
AChE
F8QV18
-
AChE
-
-
AChE1
-
isoform
AChE1
D2U6X5
isoform
AChE2
-
isoform
AChE2
D2U6X6
isoform
Checx1
B7ZF08
-
Checx2
B7ZF09
-
Checx3
B7ZF10
-
choline esterase I
-
-
-
-
cholinesterase
-
-
-
-
cholinesterase
-
-
cholinesterase
-
-
cholinesterase 2
-
-
esterase, acetyl choline
-
-
-
-
true cholinesterase
-
-
-
-
type VI-S AChE
-
-
membrane-bound acetylcholinesterase
-
-
additional information
-
cf. EC 3.1.1.8
additional information
-
the enzyme belongs to the superfamily of alpha/beta-hydrolase fold proteins
CAS REGISTRY NUMBER
COMMENTARY
9000-81-1
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
yellow fever mosquito
-
-
Manually annotated by BRENDA team
razorbill
-
-
Manually annotated by BRENDA team
Malaria mosquito
-
-
Manually annotated by BRENDA team
cotton aphid
-
-
Manually annotated by BRENDA team
German cockroach
-
-
Manually annotated by BRENDA team
immobilised on a Langmuir-Blodgett proteo-glycolipidic bilayer
-
-
Manually annotated by BRENDA team
male and female Hartley guinea pigs
-
-
Manually annotated by BRENDA team
Cimex lectularius Bedbug
Bedbug
-
-
Manually annotated by BRENDA team
carboxylesterase 1 fragment
UniProt
Manually annotated by BRENDA team
carboxylesterase 2 fragment
UniProt
Manually annotated by BRENDA team
carboxylesterase 3 fragment
UniProt
Manually annotated by BRENDA team
Nothern house mosquito
-
-
Manually annotated by BRENDA team
recombinant enzyme, wild-type and truncated mutants
-
-
Manually annotated by BRENDA team
Drosophila melanogaster MH19
strain MH19
-
-
Manually annotated by BRENDA team
type VI-S enzyme
-
-
Manually annotated by BRENDA team
cotton aphid
-
-
Manually annotated by BRENDA team
Atlantic puffin
-
-
Manually annotated by BRENDA team
blood-sucking stomach worm of domestic animals
-
-
Manually annotated by BRENDA team
multi-colored Asian ladybird beetle
-
-
Manually annotated by BRENDA team
eight different Egyptian strains EA2, EB6, EB7, EG7, EG8, EG9, EK1 and EK2, different isozymes, i.e. AChE1A, isozyme pattern
-
-
Manually annotated by BRENDA team
commercial preparation
-
-
Manually annotated by BRENDA team
R-isoform, expression in Nicotiana benthamiana, or commercial preparation
-
-
Manually annotated by BRENDA team
recombinant protein
-
-
Manually annotated by BRENDA team
vitiligo patients with almost absent acetylcholinesterase
-
-
Manually annotated by BRENDA team
strain 105
-
-
Manually annotated by BRENDA team
Hydra magnipapillata 105
strain 105
-
-
Manually annotated by BRENDA team
populations from Sichuan Province, Hubei Province and Chongqing Municipality
-
-
Manually annotated by BRENDA team
collected from Huanghua and Pingshan County
-
-
Manually annotated by BRENDA team
Australian sheep blowfly
UniProt
Manually annotated by BRENDA team
sea urchins collected from St. Joseph Bay, Florida in May of 2006
-
-
Manually annotated by BRENDA team
exon 2; rhesus macaque; exon 3; rhesus macaque; exon 4; rhesus macaque; exon 6; rhesus macaque
UniProt
Manually annotated by BRENDA team
exon 5; rhesus macaque
SwissProt
Manually annotated by BRENDA team
isoforms G1 and G4
-
-
Manually annotated by BRENDA team
male Balb-c mice
-
-
Manually annotated by BRENDA team
male BALB/c mice, C57BL/6 mice with a7nAChR deficiency and wild-type littermates
-
-
Manually annotated by BRENDA team
male C57BL6/J mice
-
-
Manually annotated by BRENDA team
male ICR mice
-
-
Manually annotated by BRENDA team
recombinant enzyme
-
-
Manually annotated by BRENDA team
Swiss adult male mice
-
-
Manually annotated by BRENDA team
treated with scopolamine
-
-
Manually annotated by BRENDA team
3 forms monomer/dimer/tetramer
-
-
Manually annotated by BRENDA team
house-fly, 5 forms
-
-
Manually annotated by BRENDA team
housefly, variants insensitive to organophosphate and carbmate insecticides
SwissProt
Manually annotated by BRENDA team
mussel
-
-
Manually annotated by BRENDA team
Nephotettix cincticeps Uhler
strains susceptible and resistant to carbamate and organophosphorus insecticides
-
-
Manually annotated by BRENDA team
albino rabbit
-
-
Manually annotated by BRENDA team
American cockroach
-
-
Manually annotated by BRENDA team
male Albino Charles Foster rats
-
-
Manually annotated by BRENDA team
male Wistar
-
-
Manually annotated by BRENDA team
whole-body hypothermia increases the degree of substrate inhibition of enzyme, its maximum rate and its Km-value
-
-
Manually annotated by BRENDA team
Wistar rats
-
-
Manually annotated by BRENDA team
several molecular forms
-
-
Manually annotated by BRENDA team
greenbug aphid
-
-
Manually annotated by BRENDA team
White Landrace pig and Goettingen minipig
-
-
Manually annotated by BRENDA team
isozyme ChE2
UniProt
Manually annotated by BRENDA team
type VI-S AChE
UniProt
Manually annotated by BRENDA team
flour beetle
-
-
Manually annotated by BRENDA team
common guillemot
-
-
Manually annotated by BRENDA team
desert cobra
-
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
physiological function
-
hydrolysis of acetylcholine by acetylcholinesterase is a key process for the regulation of the neutral response system
physiological function
-
AChE is a pivotal enzyme in the cholinergic nervous system. Its primary function is to catalyze hydrolysis of released acetylcholine and thus maintain homeostasis of this neurotransmitter in the central and peripheral nervous systems
physiological function
-
isoform AChE1 plays a major role in postsynaptic transmission
malfunction
-
Alzheimer's disease, a neurodegenerative disease characterized by a low concentration of acetylcholine in the hippocampus and cortex, is the leading cause of dementia among older people
additional information
-
regeneration is controlled by the non-neuronal cholinergic system in Hydra
additional information
Hydra magnipapillata 105
-
regeneration is controlled by the non-neuronal cholinergic system in Hydra
-
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(S)-butyrylthiocholine iodide + H2O
thiocholine iodide + (S)-butyrate
show the reaction diagram
-
-
-
-
?
2,6-dichloro-3'-methylindophenylacetate + H2O
2,6-dichloro-3'-methylindophenol + acetate
show the reaction diagram
-
-
-
?
2,6-dichloro-3'-methylindophenylacetate + H2O
2,6-dichloro-3'-methylindophenol + acetate
show the reaction diagram
-
weak substrate
-
?
2,6-dichlorophenolindophenylacetate + H2O
2,6-dichlorophenolindophenol + acetate
show the reaction diagram
-
-
-
?
2-methoxyacetylthiocholine + H2O
thiocholine + 2-methoxyacetate
show the reaction diagram
-
recombinant enzyme shows about 12% activity compared to acetylthiocholine
-
-
?
2-methoxyacetylthiocholine + H2O
thiocholine + 2-methoxyacetate
show the reaction diagram
-, P91954
recombinant enzyme shows about 65% activity compared to acetylthiocholine
-
-
?
3',5'-dichloro-2'-methylindophenylacetate + H2O
3',5'-dichloro-2'-methylindophenol + acetate
show the reaction diagram
-
weak substrate
-
?
3',5'-dichlorophenolindophenylacetate + H2O
3',5'-dichlorophenolindophenol + acetate
show the reaction diagram
-
weak substrate
-
?
3-(acetamido)-N,N,N-trimethylanilinium + H2O
?
show the reaction diagram
-
slow hydrolysis
-
-
?
3-(acetamido)-N,N,N-trimethylanilinum + H2O
?
show the reaction diagram
-
ATMA
-
?
3-methylbutyrylthiocholine + H2O
thiocholine + 3-methylbutyrate
show the reaction diagram
-
recombinant enzyme shows about 1% activity compared to acetylthiocholine
-
-
?
3-methylbutyrylthiocholine + H2O
thiocholine + 3-methylbutyrate
show the reaction diagram
-, P91954
recombinant enzyme shows less than 1% activity compared to acetylthiocholine
-
-
?
acetyl(beta-methyl)thiocholine iodide + H2O
thiocholine iodide + beta-methyl-acetate
show the reaction diagram
-
-
-
-
?
acetyl-(beta-methyl)thiocholine + H2O
(beta-methyl)thiocholine + acetate
show the reaction diagram
-
-
-
?
acetyl-(beta-methyl)thiocholine iodide + H2O
acetate + methylthiocholine iodide
show the reaction diagram
-
-
-
-
?
acetyl-beta-methyl-thiocholine + H2O
beta-methyl-thiocholine + acetate
show the reaction diagram
-
-
-
?
acetyl-beta-methylcholine + H2O
methylcholine + acetate
show the reaction diagram
-
-
-
?
acetyl-beta-methylthiocholine + H2O
beta-methylthiocholine + acetate
show the reaction diagram
-
-
-
?
acetyl-beta-methylthiocholine + H2O
? + acetate
show the reaction diagram
-
-
-
-
?
acetyl-homo-thiocholine + H2O
?
show the reaction diagram
-
recombinant enzyme shows less than 10% activity compared to acetylthiocholine
-
-
?
acetyl-homo-thiocholine + H2O
?
show the reaction diagram
P91954
recombinant enzyme shows less than 10% activity compared to acetylthiocholine
-
-
?
acetyl-[beta-methyl]thiocholine + H2O
acetate + [beta-methyl]thiocholine
show the reaction diagram
-
-
-
-
?
acetyl-[beta-methyl]thiocholine + H2O
acetate + [beta-methyl]thiocholine
show the reaction diagram
-
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
acetylcholinesterase plays in vivo a key role in cholinergic transmission by catalysing the rapid hydrolysis of the neurotransmitter acetylcholine into acetate and choline
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
acetylcholine protects cardiomyocytes from prolonged hypoxia through activation of the PI3K/Akt/HIF-1alpha/VEGF pathway and that cardiomyocyte-derived VEGF promotes angiogenesis in a paracrine fashion
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
Cimex lectularius Bedbug
-
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
P21836
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
P04058
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
esteratic and anionic subsites act together to achieve substrate binding specificity
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
key enzyme in the central and peripheral nervous systems where it is responsible for the hydrolysis of neurotransmitter acetylcholine into choline and acetate
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
the enzyme might be involved in slowing of neurodegeneration in Alzheimerís and Parkinsonís diseases, overview
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
substrate traffic in AChE involves at least two binding sites, the catalytic and peripheral anionic sites, which are allosterically related and involved in substrate inhibition, structure-function relationship analysis, overview
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
fast hydrolysis
-
-
?
acetylcholine + H2O
?
show the reaction diagram
-
-
-
-
-
acetylcholine + H2O
?
show the reaction diagram
-
-
-
-
-
acetylcholine + H2O
?
show the reaction diagram
-
-
-
-
-
acetylcholine + H2O
?
show the reaction diagram
-
inactivation of transmitter substance operating in cholinergic neurotransmission
-
-
-
acetylcholine + H2O
?
show the reaction diagram
-
inactivation of transmitter substance operating in cholinergic neurotransmission
-
-
-
acetylcholine + H2O
?
show the reaction diagram
-
inactivation of transmitter substance operating in cholinergic neurotransmission
-
-
-
acetylcholine + H2O
?
show the reaction diagram
-
inactivation of transmitter substance operating in cholinergic neurotransmission
-
-
-
acetylcholine + H2O
?
show the reaction diagram
-
inactivation of transmitter substance operating in cholinergic neurotransmission
-
-
-
acetylcholine + H2O
?
show the reaction diagram
-
inactivation of transmitter substance operating in cholinergic neurotransmission
-
-
-
acetylcholine + H2O
?
show the reaction diagram
-
inactivation of transmitter substance operating in cholinergic neurotransmission
-
-
-
acetylcholine + H2O
?
show the reaction diagram
-
inactivation of transmitter substance operating in cholinergic neurotransmission
-
-
-
acetylcholine + H2O
?
show the reaction diagram
-
synaptic transmission, termination of impulse transmission at cholinergic synapses by hydrolysis
-
-
-
acetylcholine + H2O
?
show the reaction diagram
Drosophila melanogaster MH19
-
-
-
-
-
acetylcholine chloride + H2O
choline chloride + acetate
show the reaction diagram
-
-
-
-
?
acetylcholine chloride + H2O
acetate + choline chloride
show the reaction diagram
-
-
-
-
?
acetylcholine iodide + H2O
acetate + choline iodide
show the reaction diagram
-
-
-
-
?
acetylcholine iodide + H2O
acetate + choline iodide
show the reaction diagram
-
-
-
?
acetylcholine iodide + H2O
acetate + choline iodide
show the reaction diagram
-
-
-
-
?
acetylcholine iodide + H2O
acetate + choline iodide
show the reaction diagram
-
-
-
?
acetylcholine iodide + H2O
acetate + choline iodide
show the reaction diagram
-
-
-
-
?
acetylcholine iodide + H2O
acetate + choline iodide
show the reaction diagram
-
-
-
?
acetylcholine iodide + H2O
acetate + choline iodide
show the reaction diagram
-
-
-
-
?
acetylcholine iodide + H2O
acetate + choline iodide
show the reaction diagram
-
-
-
-
?
acetylcholine iodide + H2O
acetate + choline iodide
show the reaction diagram
-
-
-
?
acetylcholine iodide + H2O
acetate + choline iodide
show the reaction diagram
-
-
-
-
-
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
P04058
-
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
detection using 5,5'-dithiobis(2-nitrobenzoic acid)
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
P23795
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
Q9DDE3
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
Q67BC1, Q67BC2
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
Q71SU7
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
Q86GL8
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
Q71SU5
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
Nephotettix cincticeps Uhler
-
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-, D2U6X5, D2U6X6
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
F8QV18, -
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
best substrate
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
best substrate
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
best substrate
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
best substrate
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
best substrate
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
preferred substrate
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
100% activity
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
P91954
100% activity
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
catalytic residues are Ser200 and Trp84
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
fast hydrolysis
-
-
?
acetylthiocholine chloride + H2O
thiocholine chloride + acetate
show the reaction diagram
-
-
-
-
?
acetylthiocholine chloride + H2O
acetate + thiocholine chloride
show the reaction diagram
-
-
-
-
?
acetylthiocholine iodide + H2O
acetate + thiocholine iodide
show the reaction diagram
-
-
-
?
acetylthiocholine iodide + H2O
acetate + thiocholine iodide
show the reaction diagram
-
-
-
-
?
acetylthiocholine iodide + H2O
acetate + thiocholine iodide
show the reaction diagram
-
-
-
?
acetylthiocholine iodide + H2O
acetate + thiocholine iodide
show the reaction diagram
-
-
-
-
?
acetylthiocholine iodide + H2O
acetate + thiocholine iodide
show the reaction diagram
-
-
-
-
?
acetylthiocholine iodide + H2O
acetate + thiocholine iodide
show the reaction diagram
P07140
detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB
-
-
?
acetylthiocholine iodide + H2O
acetate + thiocholine iodide
show the reaction diagram
-
detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB
-
-
?
acetylthiocholine iodide + H2O
acetate + thiocholine iodide
show the reaction diagram
-
detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB
-
-
?
acetylthiocholine iodide + H2O
acetate + thiocholine iodide
show the reaction diagram
-
detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB
-
-
?
acetylthiocholine iodide + H2O
thiocholine iodide + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine iodide + H2O
thiocholine iodide + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine iodide + H2O
thiocholine iodide + acetate
show the reaction diagram
-
-
-
-
?
acetylthiocholine iodide + H2O
thiocholine iodide + acetate
show the reaction diagram
-
-
-
-
?
acetylthiocholine iodide + H2O
thiocholine iodide + acetate
show the reaction diagram
-
-
-
-
?
acetylthiocholine iodide + H2O
thiocholine iodide + acetate
show the reaction diagram
-
-
-
-
?
acetylthiocholine iodide + H2O
thiocholine iodide + acetate
show the reaction diagram
-
-
-
-
?
acetylthiocholine iodide + H2O
thiocholine iodide + acetate
show the reaction diagram
Q95P20
-
-
?
acetylthiocholine iodide + H2O
thiocholine iodide + acetate
show the reaction diagram
-
-
-
-
?
acetylthiocholine iodide + H2O
thiocholine iodide + acetate
show the reaction diagram
-
-
-
-
?
acetylthiocholine iodide + H2O
thiocholine iodide + acetate
show the reaction diagram
-
preferred substrate
-
-
?
acetylthiocholine iodide + H2O
thiocholine iodide + acetate
show the reaction diagram
-
highly preferred substrate
-
-
?
acetylthiocholine iodide + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
-
?
alkyl methylphosphonfluoridate + H2O
?
show the reaction diagram
-
oxime-assisted catalysis of organophosphates by AChE, mechanism, reaction system, overview
-
-
?
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
show the reaction diagram
-
-
-
-
?
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
show the reaction diagram
-
-
-
-
?
alpha-naphthyl acetate + H2O
naphthol + acetate
show the reaction diagram
-
-
-
-
?
aryl-acyl-amides + H2O
?
show the reaction diagram
-
-
-
-
?
benzoylthiocholine + H2O
thiocholine + benzoate
show the reaction diagram
-
recombinant enzyme shows about 1% activity compared to acetylthiocholine
-
-
?
benzoylthiocholine + H2O
thiocholine + benzoate
show the reaction diagram
P91954
recombinant enzyme shows about 1% activity compared to acetylthiocholine
-
-
?
benzoylthiocholine iodide + H2O
thiocholine iodide + benzoate
show the reaction diagram
-
22.2% activity compared to acetylthiocholine
-
-
?
butyrylthiocholine + H2O
butyrate + thiocholine
show the reaction diagram
-
-
-
-
?
butyrylthiocholine + H2O
butyrate + thiocholine
show the reaction diagram
-
-
-
-
?
butyrylthiocholine + H2O
butyrate + thiocholine
show the reaction diagram
-
-
-
-
?
butyrylthiocholine + H2O
butyrate + thiocholine
show the reaction diagram
-
-
-
-
?
butyrylthiocholine + H2O
butyrate + thiocholine
show the reaction diagram
-
-
-
-
?
butyrylthiocholine + H2O
butyrate + thiocholine
show the reaction diagram
-
-
-
-
?
butyrylthiocholine + H2O
butyrate + thiocholine
show the reaction diagram
-
-
-
-
?
butyrylthiocholine + H2O
butyrate + thiocholine
show the reaction diagram
Q71SU7
-
-
-
?
butyrylthiocholine + H2O
butyrate + thiocholine
show the reaction diagram
Q86GL8
-
-
-
?
butyrylthiocholine + H2O
butyrate + thiocholine
show the reaction diagram
Q71SU5
-
-
-
?
butyrylthiocholine + H2O
butyrate + thiocholine
show the reaction diagram
Nephotettix cincticeps Uhler
-
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-, D2U6X5, D2U6X6
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
F8QV18, -
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
worst substrate
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-, P91954
native enzyme shows about 50% activity and recombinant enzyme shows about 45% activity compared to acetylthiocholine
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
recombinant enzyme shows about 3% activity compared to acetylthiocholine
-
-
?
butyrylthiocholine + H2O
thiocholine + butanoate
show the reaction diagram
-
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butanoate
show the reaction diagram
-
-
very bad substrate
-
?
butyrylthiocholine iodide + H2O
thiocholine iodide + butyrate
show the reaction diagram
-
-
-
-
?
butyrylthiocholine iodide + H2O
thiocholine iodide + butyrate
show the reaction diagram
-
-
-
-
?
butyrylthiocholine iodide + H2O
thiocholine iodide + butyrate
show the reaction diagram
B7X755, -
-
-
-
?
butyrylthiocholine iodide + H2O
thiocholine iodide + butyrate
show the reaction diagram
-
low activity
-
-
?
butyrylthiocholine iodide + H2O
thiocholine iodide + butyrate
show the reaction diagram
-
41.7% activity compared to acetylthiocholine
-
-
?
carbachol + H2O
?
show the reaction diagram
-
slow hydrolysis
-
-
?
cyclopentanoylthiocholine + H2O
thiocholine + cyclopentanoate
show the reaction diagram
-
recombinant enzyme shows about 4% activity compared to acetylthiocholine
-
-
?
cyclopentanoylthiocholine + H2O
thiocholine + cyclopentanoate
show the reaction diagram
-, P91954
recombinant enzyme shows less than 1% activity compared to acetylthiocholine
-
-
?
cyclopropanoylthiocholine + H2O
thiocholine + cyclopropanoate
show the reaction diagram
-
recombinant enzyme shows about 4% activity compared to acetylthiocholine
-
-
?
cyclopropanoylthiocholine + H2O
thiocholine + cyclopropanoate
show the reaction diagram
-, P91954
recombinant enzyme shows about 5% activity compared to acetylthiocholine
-
-
?
diisopropyl phosphofluoridate + H2O
?
show the reaction diagram
-
mutant G117H, no activity with the wild-type enzyme
-
-
?
diisopropyl phosphofluoridate + H2O
?
show the reaction diagram
-
mutant G122H/Y124Q/S125T, no activity with the wild-type enzyme
-
-
?
echothiophate + H2O
?
show the reaction diagram
-
mutant G117H, no activity with the wild-type enzyme
-
-
?
echothiophate + H2O
?
show the reaction diagram
-
mutant G122H/Y124Q/S125T, no activity with the wild-type enzyme
-
-
?
edrophonium chloride + H2O
?
show the reaction diagram
-
-
-
-
?
hexanoylthiocholine + H2O
thiocholine + hexanoate
show the reaction diagram
-
recombinant enzyme shows about 6% activity compared to acetylthiocholine
-
-
?
hexanoylthiocholine + H2O
thiocholine + hexanoate
show the reaction diagram
-, P91954
recombinant enzyme shows less than 1% activity compared to acetylthiocholine
-
-
?
indophenylacetate + H2O
indophenol + acetate
show the reaction diagram
-
-
-
?
isobutyrylthiocholine + H2O
thiocholine + isobutyrate
show the reaction diagram
-, P91954
recombinant enzyme shows about 15% activity compared to acetylthiocholine
-
-
?
isobutyrylthiocholine + H2O
thiocholine + isobutyrate
show the reaction diagram
-
recombinant enzyme shows about 2% activity compared to acetylthiocholine
-
-
?
Leu + Arg
Tyr + Gly
show the reaction diagram
-
-
-
?
neuropeptides + H2O
?
show the reaction diagram
-
degradation
-
-
-
paraoxon + H2O
?
show the reaction diagram
-
mutant G117H, no activity with the wild-type enzyme
-
-
?
paraoxon + H2O
?
show the reaction diagram
-
mutant G122H/Y124Q/S125T, no activity with the wild-type enzyme
-
-
?
pentanoylthiocholine + H2O
thiocholine + pentanoate
show the reaction diagram
-
recombinant enzyme shows about 5% activity compared to acetylthiocholine
-
-
?
pentanoylthiocholine + H2O
thiocholine + pentanoate
show the reaction diagram
P91954
recombinant enzyme shows about 5% activity compared to acetylthiocholine
-
-
?
Phe + Leu
Gly + Gly + Gly
show the reaction diagram
-
-
-
?
phenylacetylthiocholine + H2O
thiocholine + phenylacetate
show the reaction diagram
-, P91954
recombinant enzyme shows about 3% activity compared to acetylthiocholine
-
-
?
phenylacetylthiocholine + H2O
thiocholine + phenylacetate
show the reaction diagram
-
recombinant enzyme shows about 7% activity compared to acetylthiocholine
-
-
?
pivaloylthiocholine + H2O
thiocholine + pivalate
show the reaction diagram
-
recombinant enzyme shows about 5% activity compared to acetylthiocholine
-
-
?
pivaloylthiocholine + H2O
thiocholine + pivalate
show the reaction diagram
-, P91954
recombinant enzyme shows less than 1% activity compared to acetylthiocholine
-
-
?
propionylcholine chloride + H2O
choline chloride + propionate
show the reaction diagram
-
-
-
-
?
propionylthiocholine + H2O
propanoate + thiocholine
show the reaction diagram
-
-
-
-
?
propionylthiocholine + H2O
propanoate + thiocholine
show the reaction diagram
-
-
-
-
?
propionylthiocholine + H2O
propanoate + thiocholine
show the reaction diagram
-
-
-
-
?
propionylthiocholine + H2O
propanoate + thiocholine
show the reaction diagram
-
-
-
-
?
propionylthiocholine + H2O
propanoate + thiocholine
show the reaction diagram
-
-
-
-
?
propionylthiocholine + H2O
propanoate + thiocholine
show the reaction diagram
Nephotettix cincticeps Uhler
-
-
-
-
?
propionylthiocholine + H2O
propanoate + thiocholine
show the reaction diagram
-
preferred over acetylthiocholine
-
-
?
propionylthiocholine + H2O
thiocholine + propionate
show the reaction diagram
-
-
-
?
propionylthiocholine + H2O
thiocholine + propionate
show the reaction diagram
-
-
-
?
propionylthiocholine + H2O
thiocholine + propionate
show the reaction diagram
-
-
-
?
propionylthiocholine + H2O
thiocholine + propionate
show the reaction diagram
-
-
-
-
?
propionylthiocholine + H2O
thiocholine + propionate
show the reaction diagram
-
-
-
-
?
propionylthiocholine + H2O
thiocholine + propionate
show the reaction diagram
-, D2U6X5, D2U6X6
-
-
-
?
propionylthiocholine + H2O
thiocholine + propionate
show the reaction diagram
-
good substrate
-
?
propionylthiocholine + H2O
thiocholine + propionate
show the reaction diagram
-, P91954
native and recombinant enzyme show about 70% activity compared to acetylthiocholine
-
-
?
propionylthiocholine + H2O
thiocholine + propionate
show the reaction diagram
-
recombinant enzyme shows about 52% activity compared to acetylthiocholine
-
-
?
propionylthiocholine chloride + H2O
thiocholine chloride + propionate
show the reaction diagram
-
-
-
-
?
propionylthiocholine iodide + H2O
thiocholine iodide + propionate
show the reaction diagram
-
-
-
-
?
propionylthiocholine iodide + H2O
thiocholine iodide + propionate
show the reaction diagram
-
-
-
-
?
propionylthiocholine iodide + H2O
thiocholine iodide + propionate
show the reaction diagram
B7X755, -
-
-
-
?
propionylthiocholine iodide + H2O
thiocholine iodide + propionate
show the reaction diagram
-
preferred substrate
-
-
?
propionylthiocholine iodide + H2O
thiocholine iodide + propionate
show the reaction diagram
-
74.6% activity compared to acetylthiocholine
-
-
?
S-acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB
-
-
?
S-acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB
-
-
?
S-acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB
-
-
?
S-acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB
-
-
?
S-acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
B7ZF08, B7ZF09, B7ZF10, -
detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB
-
-
?
S-acetylthiocholine iodide + H2O
acetate + thiocholine iodide
show the reaction diagram
-
detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB
-
-
?
S-acetylthiocholine iodide + H2O
acetate + thiocholine iodide
show the reaction diagram
-
detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB
-
-
?
S-acetylthiocholine iodide + H2O
acetate + thiocholine iodide
show the reaction diagram
-
detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB
-
-
?
S-acetylthiocholine iodide + H2O
acetate + thiocholine iodide
show the reaction diagram
-
detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB
-
-
?
S-acetylthiocholine iodide + H2O
acetate + thiocholine iodide
show the reaction diagram
-
detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB
-
-
?
S-acetylthiocholine iodide + H2O
acetate + thiocholine iodide
show the reaction diagram
B7X755, -
detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB, the enzyme contains a Ser, Glu, and His catalytic triad, overview
-
-
?
S-butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
?
S-butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
-
?
succinyldicholine + H2O
2 choline + succinate
show the reaction diagram
-
-
-
-
?
[leu5] enkephalin + H2O
Tyr + Leu
show the reaction diagram
-
-
-
?
[met5] enkephalins + H2O
Tyr + Met
show the reaction diagram
-
-
-
?
Leu + Met
substance P
show the reaction diagram
-
-
-
?
additional information
?
-
-
-
-
-
-
additional information
?
-
-
-
-
-
-
additional information
?
-
-
-
-
-
-
additional information
?
-
-
-
-
-
-
additional information
?
-
-
-
-
-
-
additional information
?
-
-
acts on a variety of acetic acid esters, also catalyzes transacetylation
-
-
-
additional information
?
-
-
not: beta-endorphin, angiotensin, oxytoxin, vasopressin
-
-
-
additional information
?
-
-
complex with fasciculin-2 exhibits hydrolytic activity in a buryrylcholinesterase-like kinetics, the switch appears to be a consequence of steric obstruction, but also the consequence of subtle rapid conformational changes around the catalytic site
-
?
additional information
?
-
-
pivotal role in the cholinergic system, rapid termination of nerve impulse transmission
-
?
additional information
?
-
Q67BC1, Q67BC2
pivotal role in the cholinergic system, rapid termination of nerve impulse transmission
-
?
additional information
?
-
-
no substrate: S-butyrylthiocholine
-
-
-
additional information
?
-
-
calcium-activated BuchE, EC 3.1.1.8, acts as a major protective mechanism against suicide inhibition of AchE by organophosphates in this non-neuronal tissue, overview
-
-
-
additional information
?
-
-
the enzyme is involved in the morphogenetic processes of neuronal and non-neuronal tissues
-
-
-
additional information
?
-
-
the reactivation of nerve agent-inhibited acetylcholinesterase by oxime is the most important step in the treatment of nerve agent poisoning, overview
-
-
-
additional information
?
-
-
lethal effects due to enzyme inhibition in vivo appear at inhibition levels over 50%
-
-
-
additional information
?
-
-
substrate and product trafficking through the active center gorge of the enzyme analyzed by crystallography and equilibrium binding, binding structures, overview
-
-
-
additional information
?
-
-
acetylcholinesterase is a serine hydrolase that catalyze the hydrolysis of acetylcholine, thus regulating cholinergic neurotransmission
-
-
-
additional information
?
-
-
AChE is an acetylcholine-hydrolyzing enzyme and is implicated in cognitive functions and probably plays important roles in neurodegenerative disorders, including Alzheimer's disease
-
-
-
additional information
?
-
-
brain acetylcholinesterase activity controls systemic cytokine levels through the cholinergic anti-inflammatory pathway, overview
-
-
-
additional information
?
-
-
inhibition of AChE, along with the butyrylcholinesterase, and restoration of acetylcholine is a therapeutic strategy in treatment of Alzheimer's disease and other forms of dementia
-
-
-
additional information
?
-
-
presenilin 1, PS1, is required for enzyme activity in the brain, PS1/A246E transgenic mice have altered AChE activity in several regions also vulnerable in Alzheimer pathology, overview
-
-
-
additional information
?
-
P07140
active site structure and substrate channels of wild-type and mutant enzymes, overview
-
-
-
additional information
?
-
B7ZF08, B7ZF09, B7ZF10, -
Checx1, Checx2, and Checx3 are three carboxylesterases, that perform the acetylcholineesterase reaction, overview
-
-
-
additional information
?
-
-
development of an assay method for quantification of the product of enzymatic reaction using substrate as internal standard, thus eliminating the need for addition of an internal standard, mass spectrometric analysis, overview
-
-
-
additional information
?
-
-
the catalytic triad is formed by His440, Glu327, and Ser200, Trp84 and Trp279 are important for the enzyme activity
-
-
-
additional information
?
-
-
AChE1 is also activity with propionylthiocholine iodide and butyrylthiocholine iodide
-
-
-
additional information
?
-
-
activity detection using a capillary electrophoresis, EMMA, method, screening method development and optimization of experimental conditions, overview
-
-
-
additional information
?
-
-
bioassay for inhibition of fibril formation, i.e. Thioflavin T assay
-
-
-
additional information
?
-
-
the ensemble of compound 1 and compound 2 can be used for the AChE activity assay and the inhibitor-screening by making use of the aggregation-induced emission feature of tetraphenyl ethylene compounds, method development, overview
-
-
-
additional information
?
-
-, D2U6X5, D2U6X6
isoform AChE1 is the dominant activity in Ctenocephalides felis imagoes
-
-
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
acetylcholinesterase plays in vivo a key role in cholinergic transmission by catalysing the rapid hydrolysis of the neurotransmitter acetylcholine into acetate and choline
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
acetylcholine protects cardiomyocytes from prolonged hypoxia through activation of the PI3K/Akt/HIF-1alpha/VEGF pathway and that cardiomyocyte-derived VEGF promotes angiogenesis in a paracrine fashion
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
key enzyme in the central and peripheral nervous systems where it is responsible for the hydrolysis of neurotransmitter acetylcholine into choline and acetate
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
the enzyme might be involved in slowing of neurodegeneration in Alzheimerís and Parkinsonís diseases, overview
-
-
?
acetylcholine + H2O
?
show the reaction diagram
-
-
-
-
-
acetylcholine + H2O
?
show the reaction diagram
-
-
-
-
-
acetylcholine + H2O
?
show the reaction diagram
-
-
-
-
-
acetylcholine + H2O
?
show the reaction diagram
-
inactivation of transmitter substance operating in cholinergic neurotransmission
-
-
-
acetylcholine + H2O
?
show the reaction diagram
-
inactivation of transmitter substance operating in cholinergic neurotransmission
-
-
-
acetylcholine + H2O
?
show the reaction diagram
-
inactivation of transmitter substance operating in cholinergic neurotransmission
-
-
-
acetylcholine + H2O
?
show the reaction diagram
-
inactivation of transmitter substance operating in cholinergic neurotransmission
-
-
-
acetylcholine + H2O
?
show the reaction diagram
-
inactivation of transmitter substance operating in cholinergic neurotransmission
-
-
-
acetylcholine + H2O
?
show the reaction diagram
-
inactivation of transmitter substance operating in cholinergic neurotransmission
-
-
-
acetylcholine + H2O
?
show the reaction diagram
-
inactivation of transmitter substance operating in cholinergic neurotransmission
-
-
-
acetylcholine + H2O
?
show the reaction diagram
-
inactivation of transmitter substance operating in cholinergic neurotransmission
-
-
-
acetylcholine + H2O
?
show the reaction diagram
-
synaptic transmission, termination of impulse transmission at cholinergic synapses by hydrolysis
-
-
-
acetylcholine + H2O
?
show the reaction diagram
Drosophila melanogaster MH19
-
-
-
-
-
acetylcholine + H2O
acetate + choline
show the reaction diagram
Cimex lectularius Bedbug
-
-
-
-
?
acetylcholine chloride + H2O
choline chloride + acetate
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
-
?
neuropeptides + H2O
?
show the reaction diagram
-
degradation
-
-
-
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
-
?
additional information
?
-
-
-
-
-
-
additional information
?
-
-
-
-
-
-
additional information
?
-
-
-
-
-
-
additional information
?
-
-
-
-
-
-
additional information
?
-
-
-
-
-
-
additional information
?
-
-
pivotal role in the cholinergic system, rapid termination of nerve impulse transmission
-
?
additional information
?
-
Q67BC1, Q67BC2
pivotal role in the cholinergic system, rapid termination of nerve impulse transmission
-
?
additional information
?
-
-
calcium-activated BuchE, EC 3.1.1.8, acts as a major protective mechanism against suicide inhibition of AchE by organophosphates in this non-neuronal tissue, overview
-
-
-
additional information
?
-
-
the enzyme is involved in the morphogenetic processes of neuronal and non-neuronal tissues
-
-
-
additional information
?
-
-
the reactivation of nerve agent-inhibited acetylcholinesterase by oxime is the most important step in the treatment of nerve agent poisoning, overview
-
-
-
additional information
?
-
-
acetylcholinesterase is a serine hydrolase that catalyze the hydrolysis of acetylcholine, thus regulating cholinergic neurotransmission
-
-
-
additional information
?
-
-
AChE is an acetylcholine-hydrolyzing enzyme and is implicated in cognitive functions and probably plays important roles in neurodegenerative disorders, including Alzheimer's disease
-
-
-
additional information
?
-
-
brain acetylcholinesterase activity controls systemic cytokine levels through the cholinergic anti-inflammatory pathway, overview
-
-
-
additional information
?
-
-
inhibition of AChE, along with the butyrylcholinesterase, and restoration of acetylcholine is a therapeutic strategy in treatment of Alzheimer's disease and other forms of dementia
-
-
-
additional information
?
-
-
presenilin 1, PS1, is required for enzyme activity in the brain, PS1/A246E transgenic mice have altered AChE activity in several regions also vulnerable in Alzheimer pathology, overview
-
-
-
METALS and IONS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
aluminium chloride
-
activates the enzyme in vitro and in vivo after oral treatment
ammonium sulfate
-
activates optimally at 0.2 M
Ca2+
-
divalent metal ion required
Ca2+
-
activation above 1 mM
Mg2+
-
divalent metal ion required, highest activity
Mg2+
-
activation above 1 mM
Mg2+
-
omission leads to a 20% decrease in activity
Mg2+
-
ameliorates inhibitory effects of AChE inhibitors
Mn2+
-
divalent metal ion required, effective in lowest concentration
Mn2+
-
activation above 1 mM
additional information
-
AchE is not affected by Ca2+
INHIBITORS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
(+)-(1S,3R,6R)-9-benzyl-3-fluoro-2,4-dioxa-9-aza-3-phosphadecalin 3-oxide
-
-
-
(+)-(1S,3R,6S)-9-benzyl-3-fluoro-2,4-dioxa-9-aza-3-phosphadecalin 3-oxide
-
-
-
(+)-(1S,3S,6R)-9-benzyl-3-fluoro-2,4-dioxa-9-aza-3-phosphadecalin 3-oxide
-
-
-
(+)-(1S,3S,6S)-9-benzyl-3-fluoro-2,4-dioxa-9-aza-3-phosphadecalin 3-oxide
-
-
-
(+)-2-carene
-
50% inhibition at 0.90 mM
(+)-3-carene
-
50% inhibition at 0.20 mM
(+)-7-deoxy-O6-buxafurandiene
-
isolated from Buxus hyrcana
(+)-alpha-pinene
-
50% inhibition at 0.4 mM
(+)-benzoylbuxidienine
-
isolated from Buxus hyrcana
(+)-Borneol
-
1 mM, 22.2% inhibition
(+)-buxapapillinine
-
isolated from Buxus hyrcana
(+)-buxaquamarine
-
isolated from Buxus hyrcana
(+)-Camphor
-
1 mM, 26.4% inhibition
(+)-cis-verbenol
-
1 mM, 17.7% inhibition
-
(+)-fenchol
-
1 mM, 37.7% inhibition
(+)-fenchone
-
1 mM, 23.3 inhibition
(+)-haemanthamine
-
-
(+)-huperzine A
-
synthetic enantiomer of the anti-Alzheimer drug (-)-huperzine A and of its natural homologue (-)-huperzine B, interacts with the anionic subsite of the active site
(+)-irehine
-
isolated from Buxus hyrcana
(+)-limonene
-
isolated from the ethanolic extract from the fruits of Pimpinella anisoides
(+)-O6-buxafurandiene
-
isolated from Buxus hyrcana
(+)-sabinene
-
isolated from the ethanolic extract from the fruits of Pimpinella anisoides
(+)-trans-myrtanol
-
1 mM, 37.15% inhibition
(-)-(1R,3R,6R)-9-benzyl-3-fluoro-2,4-dioxa-9-aza-3-phosphadecalin 3-oxide
-
-
-
(-)-(1R,3S,6R)-9-benzyl-3-fluoro-2,4-dioxa-9-aza-3-phosphadecalin 3-oxide
-
-
-
(-)-(1S,3R,6R)-9-benzyl-3-fluoro-2,4-dioxa-9-aza-3-phosphadecalin 3-oxide
-
-
-
(-)-(1S,3S,6R)-9-benzyl-3-fluoro-2,4-dioxa-9-aza-3-phosphadecalin 3-oxide
-
-
-
(-)-10,10-dimethylhuperzine A
-
-
(-)-3-O-acetyl-spectaline
-
isolated from flowers of Senna spectabilis
(-)-alpha-pinene
-
50% inhibition at 0.44 mM
(-)-beta-pinene
-
1 mM, 48.5% inhibition
(-)-borneol
-
1 mM, 22.6% inhibition
(-)-Camphor
-
1 mM, 21.2% inhibition
(-)-fenchone
-
1 mM, 28.2% inhibition
(-)-galanthamine
-
isolated from Galanthus woronowii
(-)-huperzine A
-
anti-Alzheimer drug
(-)-huperzine B
-
-
(-)-myrtenol
-
1 mM, 15.0% inhibition
(-)-S-3-[1-(dimethylamino)ethyl]phenol
-
competitive reversible inhibitor
(-)-spectaline
-
isolated from flowers of Senna spectabilis
(-)-trans-myrtanol
-
1 mM, 37.4% inhibition
(-)-verbenone
-
1 mM, 12.6% inhibition
(1alpha,3beta,22R)-stigmast-5-ene-1,3,22-triol
-
i.e. haloxysterol A, isolated from Haloxylon recurvum
(1alpha,3beta,22R)-stigmasta-4,6-diene-1,3,22-triol
-
i.e. haloxysterol B, isolated from Haloxylon recurvum
(1alpha,3beta,5alpha,6beta,22R)-stigmastane-1,3,5,6,22-pentol
-
i.e. haloxysterol D, isolated from Haloxylon recurvum
(1S,2R)-N-(1-benzyl-2-hydroxy-3-(S)-[2-(1-benzylpiperidin-4-yl)ethylamino]-propyl)-5-nitro-N'-[(R)-1-phenylethyl]isophthalamide
-
-
(1S,2R)-N-(1-benzyl-2-hydroxy-3-(S)-[2-(1-benzylpiperidin-4-yl)ethylamino]-propyl)-5-[methyl(methylsulfonyl)-amino]-N'-[(R)-1-(4-fluorophenyl)ethyl]isophthalamide
-
-
(1S,2R)-N-(1-benzyl-2-hydroxy-3-(S)-[2-(1-benzylpiperidin-4-yl)ethylamino]-propyl)-5-[methyl(methylsulfonyl)amino]-N-[(R)-1-phenylethyl]isophthalamide
-
shows inhibitory effects on beta amyloid production of amyloid precursor protein-transfected HEK293 cells and mild protective effect against hydrogen peroxide-induced cell injury
(1S,2R)-N-(1-benzyl-2-hydroxy-3-(S)-[2-(1-benzylpiperidin-4-yl)ethylamino]-propyl)-N',N'-dipropyl-5-nitroisophthalamide
-
-
(1S,2R)-N-(1-benzyl-2-hydroxy-3-(S)-[2-(1-benzylpiperidin-4-yl)ethylamino]-propyl)-N',N'-dipropyl-5-[methyl(methylsulfonyl)amino]isophthalamide
-
-
(1S,2R)-N-(1-benzyl-2-hydroxy-3-(S)-[2-(1-benzylpiperidin-4-yl)ethylamino]-propyl)-N',N'-dipropylisophthalamide
-
-
(1S,2R)-N-(1-benzyl-2-hydroxy-3-(S)-[2-(1-benzylpiperidin-4-yl)ethylamino]-propyl)-N'-[(R)-1-(4-fluorophenyl)ethyl]-5-nitroisophthalamide
-
-
(1S,2R)-N-(1-benzyl-2-hydroxy-3-(S)-[2-(1-benzylpiperidin-4-yl)ethylamino]-propyl)-N'-[(R)-1-(4-fluorophenyl)ethyl]-isophthalamide
-
-
(1S,2R)-N-(1-benzyl-2-hydroxy-3-(S)-[2-(1-benzylpiperidin-4-yl)ethylamino]-propyl)-N'-[(R)-1-phenylethyl]isophthalamide
-
-
(1S,2S,11bS)-4-[2-(acetyloxy)ethyl]-5-methyl-1,2,3,4,4a,5,6,11b-octahydro[1,3]dioxolo[4,5-j]phenanthridine-1,2-diyl diacetate
-
-
(1S,2S,11bS)-4-[2-(acetyloxy)ethyl]-5-methyl-1,2,4a,5,6,11b-hexahydro[1,3]dioxolo[4,5-j]phenanthridine-1,2-diyl diacetate
-
-
(2-methoxy-7-methyl-2-oxido-2,3,4,5-tetrahydro-1,2-oxaphosphepin-6-yl)methanol
-
-
(22R)-22-hydroxystigmasta-4,9(11)-dien-3-one
-
i.e. haloxysterol C, isolated from Haloxylon recurvum
(24S)-ethylcholesta-7,9(11),22(E)-triene-3beta-ol
-
isolated from Haloxylon recurvum
(2E)-1,3-diphenylprop-2-en-1-one
-
-
(2E)-1-(5-chloro-2-hydroxyphenyl)-3-(4-chlorophenyl)prop-2-en-1-one
-
-
(2E)-3-(2-hydroxyphenyl)-1-phenylprop-2-en-1-one
-
-
(2E)-3-(3,4-dimethoxyphenyl)-1-phenylprop-2-en-1-one
-
-
(2E)-3-(3-hydroxyphenyl)-1-phenylprop-2-en-1-one
-
-
(2E)-3-(4-hydroxyphenyl)-1-phenylprop-2-en-1-one
-
-
(2E)-3-(4-methoxyphenyl)-1-phenylprop-2-en-1-one
-
-
(3,4-dimethoxyphenyl)(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)methanol
-
-
(3,4-dimethoxyphenyl)-(4-([(2-dimethylaminoethyl)-methylamino]methyl)phenyl)-methanone
-
-
(3,4-dimethoxyphenyl)-(4-([(2-methoxybenzyl)methylamino]methyl)phenyl)-methanone
-
-
(3,4-dimethoxyphenyl)-(4-([methyl-(3-methylbenzyl)amino]methyl)phenyl)methanone
-
-
(3,4-dimethoxyphenyl)-(4-([methyl-(3-nitrobenzyl)amino]methyl)phenyl)methanone
-
-
(3,4-dimethoxyphenyl)-(4-morpholin-4-ylmethylphenyl)methanone
-
-
(3,4-dimethoxyphenyl)-(4-[(methylprop-2-ynylamino)-methyl]phenyl)methanone
-
-
(3,4-dimethoxyphenyl)-{4-[(ethylpropylamino)methyl]phenyl}methanone
-
-
(3aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo(2,3-b)indol-5-yl (2-methylphenyl)carbamate
-
50% inhibition at 10 nM
(3aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo(2,3-b)indol-5-yl (4-isopropylphenyl)carbamate
-
50% inhibition at 760 nM
(3aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo(2,3-b)indol-5-yl ethylcarbamate
-
50% inhibition at 94 nM
(3aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo(2,3-b)indol-5-yl methylcarbamate
-
50% inhibition at 28 nM
(3aR)-3a,8-dimethyl-3,3a,8,8a-tetrahydro-2H-furo(2,3-b)indol-5-yl (2-methylphenyl)carbamate
-
50% inhibition at 13 nM
(3aR)-3a,8-dimethyl-3,3a,8,8a-tetrahydro-2H-furo(2,3-b)indol-5-yl (4-isopropylphenyl)carbamate
-
50% inhibition at 3860 nM
(3aR)-3a,8-dimethyl-3,3a,8,8a-tetrahydro-2H-furo(2,3-b)indol-5-yl ethylcarbamate
-
50% inhibition at 82 nM
(3aR)-3a,8-dimethyl-3,3a,8,8a-tetrahydro-2H-furo(2,3-b)indol-5-yl methylcarbamate
-
50% inhibition at 27 nM
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (2,3-dimethylphenyl)carbamate
-
-
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (2,4,6-trimethylphenyl)carbamate
-
-
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (2,4-dimethylphenyl)carbamate
-
-
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (2,5-dimethylphenyl)carbamate
-
-
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (2,6-dimethylphenyl)carbamate
-
-
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (2-ethylphenyl)carbamate
-
-
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (3,4-dimethylphenyl)carbamate
-
-
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (3-methylphenyl)carbamate
-
-
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (4-methylphenyl)carbamate
-
-
(3beta,4beta,5beta,6beta,8xi,9xi,14xi,17xi,22R)-4,28-dihydroxy-3-methoxy-1,26-dioxo-5,6:22,26-diepoxyergost-24-en-19-oic acid
-
-
(3beta,4beta,5beta,6beta,8xi,9xi,14xi,17xi,22R)-4,28-dihydroxy-3-methoxy-5,6:22,26-diepoxyergost-24-ene-1,26-dione
-
-
(3beta,4beta,6beta,8xi,9xi,14xi,17xi,22R)-4,6,27-trihydroxy-3-methoxy-22,26-epoxyergost-24-ene-1,26-dione
-
-
(3E)-3-([4-[2-(diethylamino)ethoxy]phenyl]methylidene)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
-
(3E)-3-([4-[3-(diethylamino)propoxy]phenyl]methylidene)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
-
(3E)-3-[(4-hydroxy-3,5-dimethoxyphenyl)methylidene]-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
-
(3E)-3-[(4-[2-[diethenyl(methylidene)-l5-azanyl]ethoxy]phenyl)methylidene]-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
-
(3E)-3-[(4-[3-[diethenyl(methylidene)-l5-azanyl]propoxy]phenyl)methylidene]-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
-
(3R,4aS,9bS)-9-(chloromethyl)-9b-[2-[(ethoxycarbonyl)(methyl)amino]ethyl]-6-methoxy-3,4,4a,9b-tetrahydrodibenzo[b,d]furan-3-yl ethyl carbonate
-
-
(3R,5aR)-3-methoxy-1-methyl-4,5,5a,6-tetrahydro-3H,8H-furo[3,4-e][1,2]oxaphosphepin-8-one 3-oxide
-
a diastereoisomeric bicyclic phosphonate analogue
(3S,5aR)-3-methoxy-1-methyl-4,5,5a,6-tetrahydro-3H,8H-furo[3,4-e][1,2]oxaphosphepin-8-one 3-oxide
-
a diastereoisomeric bicyclic phosphonate analogue
(4-([benzyl-(2-dimethylaminoethyl)amino]methyl)-phenyl)-(3,4-dimethoxyphenyl)methanone
-
-
(4-([benzyl-(2-hydroxyethyl)amino]methyl)phenyl)-(3,4-dimethoxyphenyl)methanone
-
-
(4-bromobenzoyl)phosphoramidic dichloride
-
-
(4-chlorobenzoyl)phosphoramidic dichloride
-
-
(4-methylbenzoyl)phosphoramidic dichloride
-
-
(4-[(benzylethylamino)methyl]phenyl)-(3,4-dimethoxyphenyl)methanone
-
-
(4-[(benzylmethylamino)methyl]phenyl)-(3,4-dimethoxyphenyl)methanone
-
-
(4-[(benzylmethylamino)methyl]phenyl)-(3-fluoro-4-methoxyphenyl)methanone
-
-
(4-[(benzylmethylamino)methyl]phenyl)-(4-methoxyphenyl)methanone
-
-
(4-[(benzylmethylamino)methyl]phenyl)naphthalen-2-yl-methanone
-
-
(4-[3-(benzylmethylamino)propenyl]phenyl)-(3,4-dimethoxyphenyl)methanone
-
-
(4aS,6R,8aS)-3-methoxy-11-methyl-5,6,10,11,13,14-hexahydro-4aH,9H-[1]benzofuro[3a,3,2-gh][3,4]benzoxazonin-6-ol
-
-
(4aS,6R,8aS)-3-methoxy-11-[8-[(4aS,6R,8aS)-3-methoxy-6-methyl-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11(12H)-yl]octyl]-5,6,9,10,11,12-hexahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-6-ol
-
-
(4aS,6R,8aS)-3-[[12-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)dodecyl]oxy]-6-hydroxy-11-methyl-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium
-
-
(4aS,6R,8aS)-3-[[8-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)octyl]oxy]-6-hydroxy-11-methyl-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium
-
-
(4aS,6R,8aS)-6-hydroxy-3-methoxy-11-[10-[(4aS,6R,8aS)-3-methoxy-6-methyl-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11(12H)-yl]decyl]-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium
-
-
(4aS,6R,8aS)-6-hydroxy-3-methoxy-11-[8-[(4aS,6R,8aS)-3-methoxy-6-methyl-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11(12H)-yl]octyl]-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium
-
-
(4aS,6R,8aS)-6-hydroxy-3-methyl-11-(10-phenyldecyl)-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium
-
-
(4aS,6R,8aS)-6-hydroxy-3-methyl-11-(8-phenyloctyl)-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium
-
-
(4beta,5beta,6beta,8xi,9xi,14xi,17xi,22R)-4,27-dihydroxy-5,6:22,26-diepoxyergosta-2,24-diene-1,26-dione
-
-
(5alpha,6alpha,7alpha,8xi,9xi,14xi,17xi,22R)-5-hydroxy-20-methyl-6,7:22,26-diepoxyergosta-2,24-diene-1,26-dione
-
-
(6,7-dimethoxyisoquinolin-1-yl)(2-methoxyphenyl)methanol
-
-
(6,7-dimethoxyisoquinolin-1-yl)(3,4-dimethoxyphenyl)methanol
-
-
(6,7-dimethoxyisoquinolin-1-yl)(3,4-dimethoxyphenyl)methanone
-
-
(7S,9R)-ar-turmerol
-
a synthetic bisabolane-type sesquiterpenoid derivative
(7S,9R)-dihydro-arturmerol
-
a synthetic bisabolane-type sesquiterpenoid derivative
(7S,9S)-arturmerol
-
a synthetic bisabolane-type sesquiterpenoid derivative
(7S,9S)-dihydro-ar-turmerol
-
a synthetic bisabolane-type sesquiterpenoid derivative
(8Z)-5,6-dihydro-8H-isoquino[1,2b]quinazolin-8-imine
-
-
(E)-2-(4-[(diethylamino)methyl]benzylidene)-5,6-dimethoxy-2,3-dihydroinden-1-one
-
i.e. BZYX, an indanone derivative, and a dual-binding-site AChE inhibitor. BZYX also shows high neuroprotection from H2O2-induced apoptosis in PC12 cells and prevents loss of membrane potential, determination with fluorescent 5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazol-carbocyanine iodide, i.e. JC-1, overview
(E)-3-(3-((1-benzylpiperidin-4-yl)methoxy)phenyl)-1-(2-hydroxy-4,5-dimethoxyphenyl)prop-2-en-1-one
-
-
(E)-3-(3-(1-benzylpiperidin-4-yloxy)phenyl)-1-(2-hydroxy-4,5-dimethoxyphenyl)prop-2-en-1-one
-
-
(E)-3-(4-((1-benzylpiperidin-4-yl)methoxy)phenyl)-1-(2-hydroxy-4,5-dimethoxyphenyl)prop-2-en-1-one
-
-
(E)-3-(4-(1-benzylpiperidin-4-yloxy)phenyl)-1-(2-hydroxy-4,5-dimethoxyphenyl)prop-2-en-1-one
-
-
(E)-dimethyl 1-(2-oxodihydrofuran-3(2H)-ylidene)ethyl phosphate
-
-
(R)-(+)-endo-2-norbornyl-N-n-butylcarbamate
-
synthesis of enantiomers for stereoselective inhibition of AChE, overview. The S-enantiomer is more potent than the R-enantiomer
(R)-(+)-exo-2-norbornyl-N-n-butylcarbamate
-
synthesis of enantiomers for stereoselective inhibition of AChE, overview. The R-enantiomer is potent, while the S-enantiomer is inactive
(R)-(+)-fenoxon sulfoxide
-
-
(R)-(+)-fenthion sulfoxide
-
-
(R,S)-1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride
-
E2020, acetylcholinesterase inhibitor used in treatment of Alzheimer's diaease, inhibition kinetics
(R,S)-1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride
-
E2020, acetylcholinesterase inhibitor used in treatment of Alzheimer's diaease, interacts with the active site and the peripheral anionic site of the enzyme
(rac) fenthion sulfoxide
-
-
(RS)-tacrine(10)-hupyridone
-
-
(S)-(-)-endo-2-norbornyl-N-n-butylcarbamate
-
synthesis of enantiomers for stereoselective inhibition of AChE, overview. The S-enantiomer is more potent than the R-enantiomer
(S)-(-)-fenoxon sulfoxide
-
-
(S)-(-)-fenthion sulfoxide
-
-
(S)-ar-curcumene
-
a synthetic bisabolane-type sesquiterpenoid derivative
(S)-ar-turmerone
-
sesquiterpenoid, a competitive inhibitor
(S)-dihydro-ar-curcumene
-
a synthetic bisabolane-type sesquiterpenoid derivative
(S)-dihydro-ar-turmerone
-
a sesquiterpenoid, a noncompetitive inhibitor
(S,S)-(-)-bis(10)-hupyridone
-
enzyme binding structure, analysis using structure PDB ID 1H22, detailed overview
(S-(2-diethylamino)isobutyl)methylphosphonothioate
-
i.e. VR, detailed analysis of inhibition kinetics
(Z)-dimethyl 1-(2-oxodihydrofuran-3(2H)-ylidene)ethyl phosphate
-
-
1,1'-(ethane-1,1-diyldifuran-5,2-diyl)bis(trifluoroethanone)
-
-
1,1'-heptane-1,7-diylbis{2-[(E)-(hydroxyimino)methyl]pyridinium}
-
reversible inhibition, 0.000385 mM reduces the activity to 76%; reversible inhibition, reduces the activity to 89% and 44% at concentrations of 0.0000385 mM and 0.000385 mM, respectively
1,1'-nonane-1,9-diylbis{2-[(E)-(hydroxyimino)methyl]pyridinium}
-
reversible inhibition, enzyme activity is inhibited to 64% and 15% at 0.0000385 mM and 0.000385 mM, respectively
1,2,11,12-tetramethoxy-7-methyl-5,6-dihydro-4H,8H-pyrido[3,2,1-de]phenanthridinium
-
-
1,2,3,10,11-pentamethoxy-7-(methoxycarbonyl)-5,6-dihydro-4H,8H-pyrido[3,2,1-de]phenanthridinium
-
-
1,2,3,4,9,9a-hexahydroacridin-9-amine
-
-
1,2-diacetyllycorine
-
-
1,2-dihydrogalanthamine
-
from Narcissus jonquilla extract
1,5,6-trimethyl-9-oxo-7H,9H-pyrano[3,4,5-ij]isoquinolin-1-ium
-
-
1,5-Bis(4-allyldimethylammonium phenyl)pentan-3-one
-
-
1,5-Bis(4-allyldimethylammonium phenyl)pentan-3-one
-
-
1,5-bis(4-allyldimethylammoniumphenyl)-pentan-3-one dibromide
-
i.e. BW284c51, complete inhibition
1,5-bis(4-allyldimethylammoniumphenyl)-pentan-3-one dibromide
-
i.e. BW284c51, complete inhibition of SS ChE at 0.1 mM, complete inhibition of DS ChE at 0.1-0.01 mM
1,5-bis(4-allyldimethylammoniumphenyl)-pentan-3-one dibromide
-
i.e. BW284c51, 98% inhibition at 0.01 mM
1,5-bis(4-allyldimethylammoniumphenyl)-pentan-3-one dibromide
-
-
1,5-bis(4-allyldimethylammoniumphenyl)-pentan-3-one dibromide
-
i.e. BW284c51, inhibits to a lesser extent than the vertebrate enzyme
1,5-bis(4-allyldimethylammoniumphenyl)-pentan-3-one dibromide
-
i.e. BW284c51
1,5-bis(allyldimethylammoniumphenyl)pentan-3-one dibromide
-
-
1,8-cineole
-
isolated from Melaleuca atlernifolia
1,8-cineole
-
IC50 is 0.015 mg/ml
1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline
-
-
1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methylisoquinolinium
-
-
1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline
-
-
1-(4,6-dimethylpyrimidin-2-yl)-3-(4-methyl-3-nitrophenyl)guanidine
-
-
1-(4-cyclopentyl-6-methylpyrimidin-2-yl)-3-(2,4-dimethylphenyl)guanidine
-
-
1-(hydroxymethyl)-5-methyloctahydro-2H-quinolizinium
-
pKi-values and comparison with inhibitory effect on horse and Berrytheutis magister butyrylcholinesterase EC 3.1.1.8
1-benzyl-3-[(2E)-4-(4-benzylpiperazin-1-yl)but-2-en-1-yl]-1,3-dihydro-2H-thieno[2,3-d]imidazol-2-one
-
-
1-benzyl-3-[(2E)-4-(4-benzylpiperazin-1-yl)but-2-en-1-yl]-6-methyl-1,3-dihydro-2H-thieno[2,3-d]imidazol-2-one
-
-
1-benzyl-3-[4-(4-benzylpiperazin-1-yl)butyl]-1,3-dihydro-2H-thieno[2,3-d]imidazol-2-one
-
-
1-dodecyl-1H-pyrrole-2,5-dione
-
-
1-epideacetylbowdensine
-
-
1-ethyl-2-[(E)-(1-ethylquinolin-2(1H)-ylidene)methyl]quinolinium
-
-
1-ethyl-2-[(Z)-(1-ethyl[1]benzothieno[3,2-d][1,3]thiazol-2(1H)-ylidene)methyl]quinolinium
-
-
1-ethyl-6-methyl-2-[(1-methyl-1,2-dihydro[1]benzofuro[3,2-d][1,3]thiazol-2-yl)methyl]quinolinium
-
-
1-methyl-1-[2-oxo-3-(7-oxo-7H-dibenzo[de,h]quinolin-9-yl)propyl]pyrrolidinium
-
-
1-methyl-1-[3-oxo-4-(7-oxo-7H-dibenzo[de,h]quinolin-9-yl)butyl]pyrrolidinium
-
-
1-methyl-1-[4-oxo-5-(7-oxo-7H-dibenzo[de,h]quinolin-9-yl)pentyl]pyrrolidinium
-
-
1-methyl-3-(3-(methylamino)cyclohexyl)pyridinium
-
pKi-values and comparison with inhibitory effect on horse and Berrytheutis magister butyrylcholinesterase EC 3.1.1.8
1-methyl-3-(methylcarbamoyl)-1,4-dihydroquinolin-5-yl dimethylcarbamate
-
-
1-methyl-3-(morpholin-4-ylcarbonyl)-1,4-dihydroquinolin-5-yl dimethylcarbamate
-
-
1-methyl-4,5-dihydro[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridin-6-ium-2-olate
-
-
1-methyl-8,10-dioxatricyclo(7.2.1.0 2,7)dodeca-2,4,6-trien-5-yl (2-methylphenyl)carbamate
-
50% inhibition at 56 nM
1-methyl-8,10-dioxatricyclo(7.2.1.0 2,7)dodeca-2,4,6-trien-5-yl (4-isopropylphenyl)carbamate
-
50% inhibition at 4300 nM
1-methyl-8,10-dioxatricyclo(7.2.1.0 2,7)dodeca-2,4,6-trien-5-yl ethylcarbamate
-
50% inhibition at 830 nM
1-naphthyl phenothiazine carbamate
-
-
1-O-acetyllycorine
-
-
1-[3-(4-benzylpiperazin-1-yl)propyl]-3-methyl-1,3-dihydro-2H-thieno[2,3-d]imidazol-2-one
-
-
1-[5-(5-nitro-1H-indazol-3-yl)thiophen-3-yl]ethanone
-
-
1-[5-[(1E)-1-hydrazinylideneethyl]-2-methoxybenzyl]piperidine
-
-
1-[5-[(1H-benzimidazol-2-ylsulfanyl)methyl]furan-2-yl]-2,2,2-trifluoroethanone
-
-
10-(2,2-dimethylpropanoyl)-10H-phenothiazine
-
relative potency EC 3.1.1.8 to EC3.1.1.7 is 4.7
10-(chloroacetyl)-10H-phenothiazine
-
relative potency EC 3.1.1.8 to EC3.1.1.7 is 7.3
10-(cyclobutylcarbonyl)-10H-phenothiazine
-
relative potency EC 3.1.1.8 to EC3.1.1.7 is 11.6
10-(cyclopropylcarbonyl)-10H-phenothiazine
-
relative potency EC 3.1.1.8 to EC3.1.1.7 is 1.9
10-(methoxyacetyl)-10H-phenothiazine
-
relative potency EC 3.1.1.8 to EC3.1.1.7 is 0.8
10-acetyl-10H-phenothiazine
-
relative potency EC 3.1.1.8 to EC3.1.1.7 is 1.1
10-butyryl-10H-phenothiazine
-
relative potency EC 3.1.1.8 to EC3.1.1.7 is 1.9
10-hydroxy-infractopicrin
-
isolated from Cortinarius infractus, inhibits acetylcholinesterase, but does not inhibit butyrylcholinesterase
10-isobutyryl-10H-phenothiazine
-
relative potency EC 3.1.1.8 to EC3.1.1.7 is 2.7
10-N-demethyl-10-N-(10-(4-(piperidin-1-ylmethyl)-phenoxy)decan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(12-(4-(piperidin-1-ylmethyl)-phenoxy)dodecan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(2-(4-(piperidin-1-ylmethyl)phenoxy)ethan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(3-(4-(piperidin-1-ylmethyl)phenoxy)propan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(4-(1-benzylpiperidin-4-yloxy)-butan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(4-(3-(1-morpholinoethyl)phenoxy)butan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(4-(4-((diethylamino)methyl)-phenoxy)butan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(4-(4-(morpholinomethyl)phenoxy)butan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(4-(4-(piperidin-1-ylmethyl)phenoxy)butan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(4-(4-(pyrrolidine-1-carbonyl)-phenoxy)butan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(5-(4-(piperidin-1-ylmethyl)phenoxy)pentan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(6-(1-benzylpiperidin-4-yloxy)-hexan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(6-(3-(1-morpholinoethyl)phenoxy)hexan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(6-(4-((diethylamino)methyl)-phenoxy)hexan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(6-(4-(morpholinomethyl)phenoxy)hexan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(6-(4-(piperidin-1-ylmethyl)phenoxy)hexan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(6-(4-(pyrrolidine-1-carbonyl)-phenoxy)hexan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(8-(4-(piperidin-1-ylmethyl)phenoxy)octan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(9-(4-(piperidin-1-ylmethyl)phenoxy)nonan-1-yl)-galanthamine
-
-
10-O-methylhostasine
-
a benzylphenethylamine alkaloid from Hosta plantaginea
10-propionyl-10H-phenothiazine
-
relative potency EC 3.1.1.8 to EC3.1.1.7 is 1.8
11-hydroxygalantamine
-
-
12-n-butoxy-demethoxykesselringine
-
-
13-methyl-5,8-dihydro-6H isoquino[1,2b]quinazolin-13-ium chloride
-
-
13-methyl-5,8-dihydro-6H-isoquino[1,2b]quinazolin-13-ium chloride
-
-
14-ethoxy-14-oxogalanthamine
-
-
19,20-dihydroervahanin A
-
-
19,20-dihydrotabernamine
-
-
1alpha,2alpha,6beta, 8alpha,15-pentaacetoxy-9beta-benzoyloxy-beta-agarofuran
-
-
1alpha,2alpha,6beta,8alpha-tetraacetoxy-9beta-benzoyloxy-15-hydroxy-beta-agarofuran
-
-
1alpha,2alpha,6beta-triacetoxy-9beta-benzoyloxy-15-hydroxy-beta-agarofuran
-
-
1alpha,2alpha,6beta-triacetoxy-9beta-benzoyloxy-8alpha,15-dihydroxy-beta-agarofuran
-
-
1alpha,6beta,8alpha-triacetoxy-9beta-furoyloxy-beta-agarofuran
-
IC50 is 0.0029 mg/ml
1alpha-acetoxy-6beta,9beta-difuroyloxy-4beta-hydroxy-beta-agarofuran
-
-
2'-ethylphenylgeneserine N-oxide
-
50% inhibition at 125 nM
2,2'-[[(E)-1,2-diphenylethene-1,2-diyl]bis(benzene-4,1-diyloxy)]diethanesulfonate
-
-
2,2-dichlorovinyl dimethyl phosphate
-
i.e. DDVP, reversible, detailed kinetic analysis
2,2-dichlorovinyl dimethyl phosphate
-
-
2,3,4-trimethylpyrimido[2,1-a]isoquinolin-5-ium
-
-
2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
-
2,3-dimethoxy-6-methyl-9H-xanthen-9-one
-
-
2-((Z)-(hydroxyimino)methyl)-1-methylpyridinium chloride
-
i.e. 2-PAM, reversible, detailed kinetic analysis
2-(1-piperidinyl)ethyl phenothiazine carbamate
-
-
2-(1-pyrrolidinyl)ethyl phenothiazine carbamate
-
-
2-(2-methyl-1H-imidazol-1-yl)-1-[2-(trifluoromethyl)-4a,10a-dihydro-10H-phenothiazin-10-yl]ethanone
-
-
2-(2-phenyl-2,3,4,5-tetrahydro-1,5-benzothiazepin-4-yl)phenol
P04058
-
2-(3-((1-benzylpiperidin-4-yl)methoxy)phenyl)-6,7-dimethoxy-4H-chromen-4-one
-
-
2-(3-((1-benzylpiperidin-4-yl)methoxy)phenyl)-6,7-dimethoxychroman-4-one
-
-
2-(3-(1-benzylpiperidin-4-yloxy)phenyl)-6,7-dimethoxy-4H-chromen-4-one
-
-
2-(3-(1-benzylpiperidin-4-yloxy)phenyl)-6,7-dimethoxychroman-4-one
-
-
2-(3-(2-(diethylamino)ethyl)phenoxy)-5,6-dimethoxyindan-1-one
-
-
2-(3-(2-(ethyl(methyl)amino)ethyl)phenoxy)-5,6-dimethoxy-indan-1-one
-
-
2-(3-(3-(diethylamino)propanoyl)phenoxy)-5,6-dimethoxy-indan-1-one
-
-
2-(3-methylphenyl)-4H-chromen-4-one
-
-
2-(4-((1-benzylpiperidin-4-yl)methoxy)phenyl)-6,7-dimethoxy-4H-chromen-4-one
-
-
2-(4-((1-benzylpiperidin-4-yl)methoxy)phenyl)-6,7-dimethoxychroman-4-one
-
-
2-(4-(1-benzylpiperidin-4-yloxy)phenyl)-6,7-dimethoxy-4H-chromen-4-one
-
-
2-(4-(1-benzylpiperidin-4-yloxy)phenyl)-6,7-dimethoxychroman-4-one
-
-
2-(4-(2-(diethylamino)acetyl)phenoxy)-5,6-dimethoxyindan-1-one
-
-
2-(4-(2-(diethylamino)ethyl)phenoxy)-5,6-dimethoxyindan-1-one
-
-
2-(4-(2-(ethyl(methyl)amino)acetyl)phenoxy)-5,6-dimethoxy-indan-1-one
-
-
2-(4-(2-(ethyl(methyl)amino)ethyl)phenoxy)-5,6-dimethoxy-indan-1-one
-
-
2-(4-(3-(diethylamino)propanoyl)phenoxy)-5,6-dimethoxy-indan-1-one
-
displays neuroprotective effect against H2O2-induced cell death
2-(4-(3-(diethylamino)propyl)phenoxy)-5,6-dimethoxyindan-1-one
-
-
2-(4-(3-(ethyl(methyl)amino)propanoyl)phenoxy)-5,6-dimethoxy-indan-1-one
-
-
2-(4-(4-(diethylamino)butanoyl)phenoxy)-5,6-dimethoxy-indan-1-one
-
-
2-(4-(4-(diethylamino)butyl)phenoxy)-5,6-dimethoxyindan-1-one
-
-
2-(4-(4-(ethyl(methyl)amino)butanoyl)phenoxy)-5,6-dimethoxy-indan-1-one
-
-
2-(4-methylphenyl)-4H-chromen-4-one
-
-
2-(4-morpholino)ethyl phenothiazine carbamate
-
-
2-(6-oxo-7,11-diazatricyclo(7.3.1.0 2,7)tridec-11-yl)ethyl acetate
-
pKi-values and comparison with inhibitory effect on horse and Berrytheutis magister butyrylcholinesterase EC 3.1.1.8
2-(dimethylamino)-7-ethyl-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)oxazin-4-one
-
50% inhibition at 0.011 mM
2-(dimethylamino)-7-isobutyl-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)oxazin-4-one
-
50% inhibition at 0.00036 mM
2-(dimethylamino)-7-methyl-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)oxazin-4-one
-
50% inhibition at 0.039 mM
2-(N,N-diethylamino)ethyl phenothiazine carbamate
-
-
2-(N,N-dimethylamino)ethyl phenothiazine carbamate
-
-
2-(trifluoromethyl)phenyl butylcarbamate
-
-
2-amino-3-[2-oxo-2-[phenyl(propan-2-yl)amino]ethyl]-1,3-thiazol-3-ium
-
-
-
2-amino-7-benzyl-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)oxazin-4-one
-
50% inhibition at 0.0059 mM
2-amino-7-benzyl-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)thiazin-4-one
-
50% inhibition at 0.0012 mM
2-chloro-5-methyl-1,3,2-benzodioxaphosphole 2-oxide
-
50% inhibition at 0.48 mM, detailed kinetic analysis
2-chloro-5-methyl-2,3-dihydro-1H-1,3,2-benzodiazaphosphole 2-oxide
-
50% inhibition at 1.54 mM, detailed kinetic analysis
2-chlorophenyl 1,2-dimethylhydrazinecarboxylate
-
-
2-chlorophenyl 1-methylhydrazinecarboxylate
-
-
2-chlorophenyl butylcarbamate
-
-
2-chlorophenyl phenothiazine carbamate
-
-
2-ethylphenyl butylcarbamate
-
-
2-methoxyphenyl butylcarbamate
-
-
2-methoxyphenyl phenothiazine carbamate
-
-
2-methylphenyl butylcarbamate
-
-
2-methylphenyl phenothiazine carbamate
-
-
2-naphthyl phenothiazine carbamate
-
-
2-nitrophenyl butylcarbamate
-
-
2-t-butylphenyl phenothiazine carbamate
-
-
2-tert-butoxyphenyl butylcarbamate
-
-
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
-
-
2-[(1-[2-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]ethyl]piperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
-
-
2-[(1-[3-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]propyl]piperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
-
-
2-[2-(4-fluorophenyl)-2,3,4,5-tetrahydro-1,5-benzothiazepin-4-yl]phenol
P04058
-
2-[2-(4-methylphenyl)-2,3,4,5-tetrahydro-1,5-benzothiazepin-4-yl]phenol
P04058
-
2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-N-[3-nitro-5-(pyridin-3-yloxy)phenyl]acetamide
-
-
2-[[2-[(5aS,7R,9aS)-1-formyl-7-hydroxy-4-methoxy-6,7-dihydrodibenzo[b,d]furan-9a(5aH)-yl]ethyl](methyl)amino]butanoic acid
-
-
2-[[2-[(5aS,7R,9aS)-7-hydroxy-1-(hydroxymethyl)-4-methoxy-6,7-dihydrodibenzo[b,d]furan-9a(5aH)-yl]ethyl](methyl)amino]butanoic acid
-
-
24-ethyl-cholest-7-ene-3,5,6-triol
-
isolated from Haloxylon recurvum
24-ethylcholest-6-ene-3,5-diol
-
isolated from Haloxylon recurvum
2alpha,11alpha-dihydroxyfawcettiine
-
-
2beta-hydroxyepipachysamine D
-
-
3,3'-((1,5-dioxopentane-1,5-diyl)bis(iminocyclohexane-3,1-diyl))bis(1-methylpyridinium)
-
pKi-values and comparison with inhibitory effect on horse and Berrytheutis magister butyrylcholinesterase EC 3.1.1.8
3,3'-[nonane-1,9-diylbis[(3S)-3-ethylazepane-1,3-diyl]]diphenol
-
binding by a bis-(-)-nor-meptazinol derivative disrupts the catalytic triad, structure analysis and molecular docking, overview
3,3-dimethylbutyl methylphosphonyl thiocholine
-
-
3-((1-benzylpiperidin-4-yl)methoxy)benzaldehyde
-
-
3-(1-benzylpiperidin-4-yloxy)benzaldehyde
-
-
3-(3-((1-benzylpiperidin-4-yl)methoxy)phenyl)-6,7-dimethoxy-4H-chromen-4-one
-
-
3-(3-(1-benzylpiperidin-4-yloxy)phenyl)-6,7-dimethoxy-4H-chromen-4-one
-
-
3-(3-methylphenyl)-2H-chromen-2-one
-
-
3-(4-((1-benzylpiperidin-4-yl)methoxy)phenyl)-6,7-dimethoxy-4H-chromen-4-one
-
-
3-(4-(1-benzylpiperidin-4-yloxy)phenyl)-6,7-dimethoxy-4H-chromen-4-one
-
-
3-(4-methylphenyl)-2H-chromen-2-one
-
-
3-(4-propoxybenzyl)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
-
3-(4-[2-[diethenyl(methylidene)-l5-azanyl]ethoxy]benzyl)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
-
3-(4-[3-[diethenyl(methylidene)-l5-azanyl]propoxy]benzyl)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
-
3-(6-oxo-6-(8-oxooctahydro-2H-2,6-methanopyrido(1,2-a)(1,5)diazocin-3(4H)-yl)hexanoyl)decahydro-8H-1,5-methanopyrido(1,2-a)(1,5)diazocin-8-one
-
pKi-values and comparison with inhibitory effect on horse and Berrytheutis magister butyrylcholinesterase EC 3.1.1.8
3-(9-hydroxy-5,6-dimethyl-7H,9H-pyrano[3,4,5-ij]isoquinolin-9-yl)propane-1,2-diol
-
-
3-(9-methoxy-5,6-dimethyl-7H,9H-pyrano[3,4,5-ij]isoquinolin-9-yl)propane-1,2-diol
-
-
3-(dimethylcarbamoyl)-1-methyl-1,4-dihydroquinolin-5-yl dimethylcarbamate
-
-
3-(dimethylcarbamoyl)-5-[(dimethylcarbamoyl)oxy]-1-methylquinolinium
-
-
3-(N,N-diethylamino)propyl phenothiazine carbamate
-
-
3-(N,N-dimethylamino) phenyl phenothiazine carbamate
-
binding by residues F329 and Y332, structure, overview
3-([7-[methyl(3-[[(methylamino)oxy]carbonyl]benzyl)amino]heptyl]oxy)-9H-xanthen-9-one
-
-
3-benzyl-1-[3-(4-benzylpiperazin-1-yl)propyl]-1,3-dihydro-2H-thieno[2,3-d]imidazol-2-one
-
-
3-carene
-
50% inhibition at 2 mM
3-chlorophenyl 1,2-dimethylhydrazinecarboxylate
-
-
3-chlorophenyl 1-methylhydrazinecarboxylate
-
-
3-chlorophenyl phenothiazine carbamate
-
-
3-ethyl-2-[(1E)-2-(phenylamino)but-1-en-1-yl]naphtho[2,3-d][1,3]oxazol-3-ium
-
-
3-ethyl-2-[(E)-(1-ethyl-6-methoxyquinolin-2(1H)-ylidene)methyl]-5-methoxy-1,3-benzothiazol-3-ium
-
-
3-ethyl-2-[(E)-(1-ethyl-6-methylquinolin-2(1H)-ylidene)methyl]-5-hydroxy-1,3-benzothiazol-3-ium
-
-
3-ethyl-2-[(E)-(1-ethylquinolin-2(1H)-ylidene)methyl]-5-iodo-1,3-benzothiazol-3-ium
-
-
3-hydroxy-2,2,6-trimethyl-3,4,5,6-tetrahydro-2H-pyrano[3,2c] quinoline 5-one
-
isolated from Skimmia laureola
3-methoxy-6-methyl-9H-xanthen-9-one
-
-
3-methoxyphenyl phenothiazine carbamate
-
-
3-methyl-2-(4-methylphenyl)-4H-chromen-4-one
-
-
3-methylphenyl phenothiazine carbamate
-
-
3-N,N-diethylaminophenyl-N'-(1-alkyl) carbamates
-
inhibit quickly by carbamoylation
3-N,N-diethylaminophenyl-N'-(1-butyl) carbamate
-
-
3-N,N-diethylaminophenyl-N'-(1-ethyl) carbamate
-
-
3-N,N-diethylaminophenyl-N'-(1-hexyl) carbamate
-
-
3-N,N-diethylaminophenyl-N'-(1-octyl) carbamate
-
-
3-N,N-diethylaminophenyl-N'-(1-propyl) carbamate
-
-
3-O-acetylhamayne
-
-
3-[10-(benzylmethylamino)decyloxy]xanthen-9-one
-
-
3-[11-(benzylmethylamino)undecyloxy]xanthen-9-one
-
-
3-[12-(benzylmethylamino)dodecyloxy]xanthen-9-one
-
-
3-[3-(benzylmethylamino)propoxy]xanthen-9-one
-
-
3-[3-[(2-methoxybenzyl)methylamino]propoxy]-xanthen-9-one
-
-
3-[4-(benzylmethylamino)butoxy]xanthen-9-one
-
-
3-[4-[3-(diethylamino)propoxy]benzyl]-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
-
3-[5-(4-chlorophenyl)-3,4-dihydro-2H-pyrano[3,2-c]quinolin-9-yl]-N-[4-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]butyl]propanamide
-
-
3-[5-(4-chlorophenyl)-3,4-dihydro-2H-pyrano[3,2-c]quinolin-9-yl]-N-[5-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]pentyl]propanamide
-
-
3-[5-(4-chlorophenyl)-3,4-dihydro-2H-pyrano[3,2-c]quinolin-9-yl]-N-[6-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]hexyl]propanamide
-
-
3-[5-(4-chlorophenyl)-3,4-dihydro-2H-pyrano[3,2-c]quinolin-9-yl]-N-[7-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]heptyl]propanamide
-
-
3-[5-(4-chlorophenyl)-3,4-dihydro-2H-pyrano[3,2-c]quinolin-9-yl]-N-[8-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]octyl]propanamide
-
-
3-[5-(benzylmethylamino)pentyloxy]xanthen-9-one
-
-
3-[6-(benzylmethylamino)hexyloxy]xanthen-9-one
-
-
3-[7-(benzylmethylamino)-heptyloxy]xanthen-9-one
-
-
3-[7-(benzylmethylamino)heptyloxy]-6-methoxyxanthen-9-one
-
-
3-[7-[(2,3-dimethoxybenzyl)methylamino]heptyloxy]xanthen-9-one
-
-
3-[7-[(2,5-dimethoxybenzyl)methylamino]heptyloxy]xanthen-9-one
-
-
3-[7-[(2-chlorobenzyl)methylamino]-heptyloxy]-xanthen-9-one
-
-
3-[7-[(2-methoxybenzyl)methylamino]heptyloxy]-xanthen-9-one
-
-
3-[7-[(3-chlorobenzyl)methylamino]-heptyloxy]-xanthen-9-one
-
-
3-[7-[(3-methoxybenzyl)methylamino]heptyloxy]-xanthen-9-one
-
-
3-[7-[(4-chlorobenzyl)methylamino]-heptyloxy]-xanthen-9-one
-
-
3-[7-[(4-methoxybenzyl)methylamino]heptyloxy]-xanthen-9-one
-
-
3-[7-[ethyl-(2-methoxybenzyl)amino]heptyloxy]-xanthen-9-one
-
-
3-[7-[methyl-(2,3,4-trimethoxybenzyl)amino]-heptyloxy]xanthen-9-one
-
-
3-[7-[methyl-(2-methylbenzyl)amino]-heptyloxy]-xanthen-9-one
-
-
3-[7-[methyl-(2-nitrobenzyl)amino]heptyloxy]-xanthen-9-one
-
-
3-[8-(benzylmethylamino)octyloxy]xanthen-9-one
-
-
3-[9-(benzylmethylamino)nonyloxy]xanthen-9-one
-
-
3-[omega-(benzylmethylamino)alkoxy]xanthen-9-ones
-
structure-activity relationships, overview
3a-methyl-2,3,3a,8a-tetrahydrofuro(2,3-b)(1)benzofuran-5-yl (2-methylphenyl)carbamate
-
50% inhibition at 23 nM
3a-methyl-2,3,3a,8a-tetrahydrofuro(2,3-b)(1)benzofuran-5-yl (4-isopropylphenyl)carbamate
-
50% inhibition at 2650 nM
3a-methyl-2,3,3a,8a-tetrahydrofuro(2,3-b)(1)benzofuran-5-yl ethylcarbamate
-
50% inhibition at 360 nM
4,5-diethyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
-
4-((1-benzylpiperidin-4-yl)methoxy)benzaldehyde
-
-
4-(1-benzylpiperidin-4-yloxy)benzaldehyde
-
-
4-(aminocarbonyl)-1-(((2-((Z)-(hydroxyimino)methyl)pyridinium-1-yl)methoxy)methyl)pyridinium dichloride
-
i.e. HI-6, reversible, detailed kinetic analysis
4-biphenyl phenothiazine carbamate
-
-
4-bromo-N-[di(morpholin-4-yl)phosphoryl]benzamide
-
-
4-chloro-N-[di(morpholin-4-yl)phosphoryl]benzamide
-
-
4-chlorophenyl 1,2-dimethylhydrazinecarboxylate
-
-
4-chlorophenyl 1-methylhydrazinecarboxylate
-
-
4-chlorophenyl phenothiazine carbamate
-
-
4-cymene
-
isolated from Melaleuca atlernifolia
4-ethenyl-5-ethyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
-
4-ethenyl-5-hexyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
-
4-ethenyl-5-methyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
-
4-ethenyl-5-pentyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
-
4-ethenyl-5-propyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
-
4-ethyl-5-hexyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine hydrobromide
-
-
4-ethyl-5-methyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
-
4-ethyl-5-pentyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
-
4-ethyl-5-propyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
-
4-ethyl-N-methyl-dihydrophenanthridine
-
-
4-ketoamyl trimethyl ammonium iodide
-
nonhydrolysable substrate analogue, mechanism of substrate inhibition
4-ketoamyltrimethylammonium
-
binding structure analysis
4-methoxyphenyl phenothiazine carbamate
-
-
4-methylphenyl phenothiazine carbamate
-
-
4-nitrophenyl allylcarbamate
-
detailed kinetic analysis and mechanism
4-nitrophenyl benzylcarbamate
-
detailed kinetic analysis and mechanism
4-nitrophenyl butylcarbamate
-
detailed kinetic analysis and mechanism
4-nitrophenyl hexylcarbamate
-
detailed kinetic analysis and mechanism
4-nitrophenyl octylcarbamate
-
detailed kinetic analysis and mechanism
4-nitrophenyl phenylcarbamate
-
detailed kinetic analysis and mechanism
4-nitrophenyl tert-butylcarbamate
-
detailed kinetic analysis and mechanism
4-O-methylhonokiol
-
isolated from ethanol extract of Magnolia officinalis. 4-O-methylhonokiol also dose-dependently attenuates the scopolamine-induced increase of AChE activity in the cortex and hippocampus of mice
4-oxo-N,N,N-trimethylpentanaminium iodide
-
i.e. OTMA, a hydrolysable substrate analogue, binding structure analysis
4-t-butylphenyl phenothiazine carbamate
-
-
4-[4-(4-benzylpiperazin-1-yl)butyl]pyrrolo[1,2-a]thieno[2,3-e]pyrazin-5(4H)-one
-
-
4-[4-(4-benzylpiperazin-1-yl)butyl]pyrrolo[1,2-a]thieno[3,2-e]pyrazin-5(4H)-one
-
-
5,5'-dithiobis(2-nitrobenzoic acid)
P04058
inactivation, the peripheral site ligand propidium accelerates inactivation in the wild type ChE2, but retards inactivation in the F312I mutant
5,6-dimethoxy-2-(3-(2-(piperidin-1-yl)ethyl)phenoxy)-indan-1-one
-
-
5,6-dimethoxy-2-(3-(2-(pyrrolidin-1-yl)ethyl)phenoxy)-indan-1-one
-
-
5,6-dimethoxy-2-(3-(3-(pyrrolidin-1-yl)propanoyl)phenoxy)-indan-1-one
-
-
5,6-dimethoxy-2-(4-(2-(piperidin-1-yl)acetyl)phenoxy)-indan-1-one
-
-
5,6-dimethoxy-2-(4-(2-(piperidin-1-yl)ethyl)phenoxy)-indan-1-one
-
-
5,6-dimethoxy-2-(4-(2-(pyrrolidin-1-yl)acetyl)phenoxy)-indan-1-one
-
-
5,6-dimethoxy-2-(4-(2-(pyrrolidin-1-yl)ethyl)phenoxy)-indan-1-one
-
-
5,6-dimethoxy-2-(4-(3-(piperidin-1-yl)propanoyl)phenoxy)-indan-1-one
-
-
5,6-dimethoxy-2-(4-(3-(piperidin-1-yl)propyl)phenoxy)-indan-1-one
-
-
5,6-dimethoxy-2-(4-(3-(pyrrolidin-1-yl)propanoyl)phenoxy)-indan-1-one
-
-
5,6-dimethoxy-2-(4-(3-(pyrrolidin-1-yl)propyl)phenoxy)-indan-1-one
-
-
5,6-dimethoxy-2-(4-(4-(piperidin-1-yl)butanoyl)phenoxy)-indan-1-one
-
-
5,6-dimethoxy-2-(4-(4-(pyrrolidin-1-yl)butanoyl)phenoxy)-indan-1-one
-
-
5,6-dimethoxy-2-(4-(4-(pyrrolidin-1-yl)butyl)phenoxy)-indan-1-one
-
-
5,6-dimethoxy-2-([1-[2-(1,2,3,4-tetrahydroacridin-9-ylamino)ethyl]piperidin-4-yl]methyl)-2,3-dihydro-1H-inden-1-one
-
-
5,6-dimethoxy-2-([1-[3-(1,2,3,4-tetrahydroacridin-9-ylamino)propyl]piperidin-4-yl]methyl)-2,3-dihydro-1H-inden-1-one
-
-
5,6-dimethoxy-9-prop-2-en-1-yl-7H,9H-pyrano[3,4,5-ij]isoquinolin-9-ol
-
-
5,7,8,13-tetrahydroindolo [2',3':3,4]pyrido[2,1-b]quinazoline
-
-
5,8-dihydro-6H isoquino[1,2b]quinazoline
-
-
5-(4-chlorophenyl)-N-[10-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]decyl]-3,4-dihydro-2H-pyrano[3,2-c]quinoline-9-carboxamide
-
-
5-(4-chlorophenyl)-N-[6-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]hexyl]-3,4-dihydro-2H-pyrano[3,2-c]quinoline-9-carboxamide
-
-
5-(4-chlorophenyl)-N-[7-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]heptyl]-3,4-dihydro-2H-pyrano[3,2-c]quinoline-9-carboxamide
-
-
5-(4-chlorophenyl)-N-[8-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]octyl]-3,4-dihydro-2H-pyrano[3,2-c]quinoline-9-carboxamide
-
-
5-(4-chlorophenyl)-N-[9-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]nonyl]-3,4-dihydro-2H-pyrano[3,2-c]quinoline-9-carboxamide
-
-
5-(4-chlorophenyl)-N-[9-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]nonyl]-3,4-dihydro-2H-pyrano[3,2-c]quinoline-9-carboxamide
-
-
5-amino-2-methyl-6,7,8,9-tetrahydrobenzo[b][1,8]naphthyridine-3-carboxylate
-
-
5-butyl-4-ethenyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
-
5-butyl-4-ethyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
-
5-hydroxy-5,6-seco-dihydrolycorine
-
-
5-hydroxy-5,6-secolycorine
-
-
5-[(1-benzylpiperidin-4-yl)methoxy]-1-methylpyrrolo[1,2-a]thieno[2,3-e]pyrazine
-
-
5-[(1-benzylpiperidin-4-yl)methoxy]pyrrolo[1,2-a]thieno[3,2-e]pyrazine
-
-
5-[(dimethylcarbamoyl)oxy]-1-methyl-3-(methylcarbamoyl)quinolinium
-
-
5-[(dimethylcarbamoyl)oxy]-1-methyl-3-(morpholin-4-ylcarbonyl)quinolinium
-
-
5-[(dimethylcarbamoyl)oxy]-3-(ethoxycarbonyl)-1-methylquinolinium
-
-
5-[(dimethylcarbamoyl)oxy]-3-(methoxycarbonyl)-1-methylquinolinium
-
-
5-[(E)-(dimethylhydrazinylidene)methyl]-1-(4-methoxy-3-nitrobenzyl)-1H-imidazole
-
-
5-[(ethylcarbamoyl)oxy]-3-(methoxycarbonyl)-1-methylquinolinium
-
-
5-[4-(4-benzylpiperazin-1-yl)butyl]-7-phenyl-1,5-dihydro-4H-furo[2,3-b]pyrrolo[2,3-d]pyridin-4-one
-
-
5alpha,8alpha-epidioxy-(24S)-ethylcholesta-6,9(11),22(E)-triene-3beta-ol
-
isolated from Haloxylon recurvum
6,7-dimethoxy-2-(3-methylphenyl)-4H-chromen-4-one
-
-
6,7-dimethoxy-3-(3-methylphenyl)-2H-chromen-2-one
-
-
6,7-dimethoxy-3-(4-methylphenyl)-2H-chromen-2-one
-
-
6-chloro-N-(2-[4-[(5,6-dimethoxy-2,3-dihydro-1H-inden-2-yl)methyl]piperidin-1-yl]ethyl)-1,2,3,4-tetrahydroacridin-9-amine
-
-
6-chloro-N-(3-[4-[(5,6-dimethoxy-2,3-dihydro-1H-inden-2-yl)methyl]piperidin-1-yl]propyl)-1,2,3,4-tetrahydroacridin-9-amine
-
-
6-chlorotacrine
-
-
6-hydroxycrinamine
-
-
6-methoxy-2-(3-methylphenyl)-4H-chromen-4-one
-
-
6-methoxy-2-(4-methylphenyl)-4H-chromen-4-one
-
-
6-methoxy-3-(3-methylphenyl)-2H-chromen-2-one
-
-
6-methoxy-3-(4-methylphenyl)-2H-chromen-2-one
-
-
6-O-demethylgalanthamine
-
-
6-[7-(benzylmethylamino)heptyloxy]-2,3-dimethoxyxanthen-9-one
-
-
6beta,8alpha-diacetoxy-9beta-furoyloxy-1alpha-hydroxy-beta-agarofuran
-
-
7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinoline
-
-
-
7-benzoyl-2-(dimethylamino)-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)oxazin-4-one
-
50% inhibition at 0.036 mM
7-benzyl-2-((3,4-dimethoxybenzyl)(methyl)amino)-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)oxazin-4-one
-
50% inhibition at 0.00033 mM
7-benzyl-2-(4-benzylpiperazin-1-yl)-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)oxazin-4-one
-
50% inhibition at 0.00132 mM
7-benzyl-2-(benzyl(methyl)amino)-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)oxazin-4-one
-
50% inhibition at 0.00084 mM
7-benzyl-2-(benzylamino)-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)oxazin-4-one
-
50% inhibition at 0.00286 mM
7-benzyl-2-(benzylamino)-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)thiazin-4-one
-
50% inhibition at 0.0052 mM
7-benzyl-2-(cyclohexylamino)-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)thiazin-4-one
-
50% inhibition at 0.00282 mM
7-benzyl-2-(diethylamino)-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)oxazin-4-one
-
50% inhibition at 0.00208 mM
7-benzyl-2-(dimethylamino)-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)oxazin-4-one
-
50% inhibition at 0.00089 mM
7-benzyl-2-(isopropylamino)-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)oxazin-4-one
-
50% inhibition at 0.00074 mM
7-benzyl-2-(isopropylamino)-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)thiazin-4-one
-
50% inhibition at 0.00058 mM
7-benzyl-2-(phenylamino)-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)oxazin-4-one
-
50% inhibition at 0.00094 mM
7-benzyl-2-(phenylamino)-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)thiazin-4-one
-
50% inhibition at 0.00103 mM
7-benzyl-2-(propan-2-ylamino)-1,2,5,6,7,8-hexahydro-4H-pyrido[4',3':4,5]thieno[2,3-d][1,3]thiazin-4-one
-
the substance acts as a hyperbolic mixed-type inhibitor
7-benzyl-2-morpholin-4-yl-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)oxazin-4-one
-
50% inhibition at 0.00077 mM
7-bromo-6-methyl-7H,9H-pyrano[3,4,5-ij]isoquinolin-9-one
-
-
7-deoxy-trans-dihydronarciclasine
-
-
7-methoxy-2-(3-methylphenyl)-4H-chromen-4-one
-
-
7-methoxy-2-(4-methylphenyl)-4H-chromen-4-one
-
-
7-methoxy-3-(3-methylphenyl)-2H-chromen-2-one
-
-
7-methoxy-3-(4-methylphenyl)-2H-chromen-2-one
-
-
7-methyloctahydro-2H-quinolizin-1-yl (7-methyloctahydro-2H-quinolizin-1-yl)methyl butanedioate
-
pKi-values and comparison with inhibitory effect on horse and Berrytheutis magister butyrylcholinesterase EC 3.1.1.8
7-[(dimethylcarbamoyl)oxy]-3-(ethoxycarbonyl)-1-methylquinolinium
-
-
8-alpha-ethoxyprecriwelline
-
-
8-demethoxy-10-O-methylhostasine
-
a benzylphenethylamine alkaloid from Hosta plantaginea
8-demethoxyhostasine
-
benzylphenethylamine alkaloid from Hosta plantaginea
8-methoxyflindersine
-
an alkaloid isolated from Waltheria brachypetala
9,10-dimethoxy-1,2,3,12,15,16-hexadehydrogalanthan
-
-
9-(2-oxo-3-pyrrolidin-1-ylpropyl)-7H-dibenzo[de,h]quinolin-7-one
-
-
9-(2-oxo-4-pyrrolidin-1-ylbutyl)-7H-dibenzo[de,h]quinolin-7-one
-
-
9-(2-oxo-5-pyrrolidin-1-ylpentyl)-7H-dibenzo[de,h]quinolin-7-one
-
-
9-(3-bromo-5-ethoxy-4-hydroxyphenyl)-3,3,6,6-tetramethyl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione
-
-
9-(4-[[2-(dimethylamino)ethyl]amino]-2-oxobutyl)-7H-dibenzo[de,h]quinolin-7-one
-
-
9-amino-1,2,3,4-tetrahydroacridin-1-ol
-
-
-
9-amino-1,2,3,4-tetrahydroacridin-1-ol
P91954
-
-
9-aminoacridine
P91954
-
9-O-demethyl-7-O-methyllycorenine
-
a benzylphenethylamine alkaloid from Hosta plantaginea
9-O-[2-(9H-carbazole-4-yloxy)ethyl] berberine bromide
-
-
9-O-[2-(benzotriazole-1-yloxy)ethyl] berberine bromide
-
-
9-O-[2-(phenylol-1-yloxy)ethyl] berberine bromide
-
-
9-O-[2-(phenylol-1-yloxy)hexyl] berberine bromide
-
-
9-O-[3-(9H-carbazole-4-yloxy)propyl] berberine bromide
-
-
9-O-[3-(benzotriazole-1-yloxy)propyl] berberine bromide
-
-
9-O-[3-(phenylol-1-yloxy)propyl] berberine bromide
-
-
9-O-[4-(9H-carbazole-4-yloxy)butyl] berberine bromide
-
-
9-O-[4-(benzotriazole-1-yloxy)butyl] berberine bromide
-
-
9-O-[4-(phenylol-1-yloxy)butyl] berberine bromide
-
most potent berberine derivative inhibitor, mixed type inhibition
9-O-[5-(9H-carbazole-4-yloxy)butyl] berberine bromide
-
-
9-O-[5-(benzotriazole-1-yloxy)pentyl] berberine bromide
-
-
9-O-[5-(phenylol-1-yloxy)pentyl] berberine bromide
-
-
9-O-[6-(9H-carbazole-4-yloxy)butyl] berberine bromide
-
-
9-O-[6-(benzotriazole-1-yloxy)hexyl] berberine bromide
-
-
9-[3-(dimethylamino)-2-oxopropyl]-7H-dibenzo[de,h]quinolin-7-one
-
-
9-[4-(diethylamino)-2-oxobutyl]-7H-dibenzo[de,h]quinolin-7-one
-
-
9-[4-(dimethylamino)-2-oxobutyl]-7H-dibenzo[de,h]quinolin-7-one
-
-
9-[4-[(2-hydroxyethyl)amino]-2-oxobutyl]-7H-dibenzo[de,h]quinolin-7-one
-
-
9-[5-(dimethylamino)-2-oxopentyl]-7H-dibenzo[de,h]quinolin-7-one
-
-
acetaldehyde
Q9DDE3
-
acetonitrile
-
a competitive pseudo-inhibition is observed for 6% acetonitrile
acetyl-[beta-methyl]thiocholine
-
-
Acetylcholine
-
-
Acetylcholine
-
-
Acetylcholine
-
above 2.5 mM
Acetylcholine
-
substrate inhibition
Acetylcholine
-
substrate inhibition above 1 mM
Acetylcholine
-
substrate inhibition above 1 mM, less pronounced than in Pseudorasbora parva or Carassius auratus auratus
Acetylcholine
-
substrate inhibition above 1 mM
Acetylcholine
-
mechanism of substrate inhibition
Acetylcholine
-
substrate inhibition due to choline exit being hindered by a substrate molecule bound at the peripheral site
acetylcholine iodide
-
substrate inhibition above 4 mM
Acetylthiocholine
-
-
Acetylthiocholine
-
substrate inhibition above 1 mM
Acetylthiocholine
-
substrate activitation at low concentrations, substrate inhibition at high concentrations
Acetylthiocholine
-
-
Acetylthiocholine
-
substrate inhibition above 2.56 mM
Acetylthiocholine
Nephotettix cincticeps Uhler
-
N-methyl carbamate-resistant strain, no substrate inhibition up to 0.01 mM
Acetylthiocholine
-
interaction with Glu199 of ATCh, substrate inhibition due to choline exit being hindered by a substrate molecule bound at the peripheral site
Acetylthiocholine
-
substrate inhibition
Acetylthiocholine
B7X755
the recombinant carp AChE shows substrate inhibition at high substrate concentrations of acetyl- and propionylthiocholine
Acetylthiocholine
-
substrate inhibition
acetylthiocholine iodide
-
above 5 mM
acetylthiocholine iodide
-
above 5 mM
acetylthiocholine iodide
B7X755
-
acrifoline
-
isolated from ethanolic extracts of Lycopodium annotinum ssp. alpestre
aflatoxin B1
-
50% inhibition at 0.031 mM by increase of Km-value and decrease of vmax-value. Partial recativation by 2-aldoxime, i.e. 2-PAM, pyridin-2-aldoxime 1-methoiodide
AH233683
P91954
-
Aldicarb
P91954
-
aldicarb-sulfone
-
-
-
aldicarb-sulfone
P91954
-
-
aldicarb-sulfoxide
-
-
-
aldicarb-sulfoxide
P91954
-
-
alpha-amyrin
-
a pentacyclic triterpene, isolated the ethanolic extract of Chuquiraga erinacea D. Don. subsp. erinacea leaves as a mixture of alpha- and beta amyrin
alpha-pinene
-
IC50 is 0.022 mg/ml
alpha-terpinen
-
isolated from Melaleuca atlernifolia
alpha-Terpineol
-
IC50 is 1.3 mg/ml
aminocarb
P91954
-
-
amlodipine besylate
-
reversible mixed-type inhibition
amlodipine besylate
-
-
anhydrolycodoline
-
isolated from ethanolic extracts of Lycopodium annotinum ssp. alpestre
annotine
-
isolated from ethanolic extracts of Lycopodium annotinum ssp. alpestre
annotine N-oxide
-
isolated from ethanolic extracts of Lycopodium annotinum ssp. alpestre
annotinine
-
isolated from ethanolic extracts of Lycopodium annotinum ssp. alpestre
Aspartame
-
and its metabolites, inhibitory above 2.8 mg per kg body weight
assoanine
-
-
azamethiphos
Q95P20
insecticide
azamethiphos
-
50% inhibition at 0.1 mM, 80% inhibition after 60 min at 0.003 mM
azamethiphos
P91954
-
bambuterol
-
50% inhibition at 0.03 mM
bambuterol
-
a specific and stereoselective inhibitor of butyrylcholinesterase, which is about 8000times faster inhibted than acetylcholinesterase. AChE wild-type enzyme, and mutants F297I/Y337A and F295L/F297I/Y337A show a deviation from linearity, either enzymes are inhibited by racemate or enantiomers, indicating the presence of reversible enzyme-inhibitor complex, overview
bendiocarb
Q95P20
insecticide
bendiocarb
P91954
-
benzoyl phosphoramidic dichloride
-
-
benzoylphosphoramidic dichloride
-
-
benzyl alcohol
-
-
Berberine
-
competitive inhibition
beta-amyrin
-
a pentacyclic triterpene, isolated the ethanolic extract of Chuquiraga erinacea D. Don. subsp. erinacea leaves as a mixture of alpha- and beta amyrin
biphenyl-2-yl butylcarbamate
-
-
bis-N,N-dimethylfulleropyrrolidinium salts
-
inhibitory activity and mechanism of cationic fulleropyrrolidinium regioisomers, AChE docking parameters, molecular modleing, overview
-
bisnorcymserine
-
50% inhibition at mM
bromchlophos
-
-
-
bromchlophos
P91954
-
-
bulbocapnine
-
isolated from Corydalis cava
butocarboxim
-
-
-
butocarboxim
P91954
-
-
butoxycarboxim
-
-
-
butoxycarboxim
P91954
-
-
butyl carbamate
-
-
butylsarin
-
detailed analysis of inhibition kinetics
butyrylthiocholine
Nephotettix cincticeps Uhler
-
N-methyl carbamate-resistant strain, no substrate inhibition up to 0.01 mM
butyrylthiocholine
B7X755
-
butyrylthiocholine iodide
B7X755
-
buxabenzacinine
-
isolated from Buxus hyrcana
buxamine-B
-
50% inhibition at 0.074 mM, noncompetitive
buxamine-C
-
50% inhibition at 0.0075 mM, noncompetitive
buxandrine
-
isolated from Buxus hyrcana
buxidin
-
isolated from Buxus hyrcana
buxippine-K
-
isolated from Buxus hyrcana
buxoviricine
-
isolated from Buxus hyrcana
BW 284C51
-
50% inhibition at 0.0063 mM
BW248c51
-
i.e. 1,5-bis(4-allyldimethyl-ammoniumphenyl)pentane-3-one dibromide, specific inhibition of AChE
BW284c51
-
0.01 mM, more than 97% inhibition
BW284c51
-
-strong
BW284c51
Q71SU5
50% inhibiton at 0.0025 mM
BW284c51
Q86GL8
50% inhibiton at 0.002 mM
BW284c51
Q71SU7
50% inhibiton at 0.0022 mM
BW284c51
-
0.001 mM, almost complete inhibition
BW284c51
-
50% inhibition at 0.000021 mM
BW284c51
-
specific inhibition of acetylthiocholinesterase activity
BW284c51
-
isozyme AChE1A, complete competitive inhibition at 0.016 mM
BW284c51
-
selective inhibitor
BW284c51
-
a reversible elongated gorge-spanning inhibitor, which bridges the two sites, the anionic subsite at the bottom of the active-site gorge and the peripheral anionic site at the entrance to the gorge
BW284c51
B7X755
-
BW284c51
P91954
-
BW4c51
-
-
-
BW4c51
-
-
-
BW4c51
-
-
-
calenduladiol
-
a pentacyclic triterpene, isolated the ethanolic extract of Chuquiraga erinacea D. Don. subsp. erinacea leaves. 31.2% inhibition at 0.5 mM
carbanolate
-
-
-
carbanolate
P91954
-
-
Carbaryl
-
i.e. Ziofil 5, a pesticide, in vivo and in vitro inhibition, 85% inhibition at 0.001 mM, clearing within 5 days, overview
Carbaryl
-, D2U6X5, D2U6X6
i.e. N-methyl-1-naphthylcarbamate, complete inhibition at concentrations exceeding 100 nM; i.e. N-methyl-1-naphthylcarbamate, complete inhibition at concentrations exceeding 100 nM
Carbaryl
P91954
-
carbofuran
P91954
-
carbosulfan
-
50% inhibition at 0.717 nM
carbosulfan
-
50% inhibition at 0.836 nM
carvacrol
-
in vitro inhibition, compound of the essential oil of Thymus vulgaris
carvacrol
-
isolated from Thymus vulgaris essential oil
chitooligosaccharides
-
90-COSs and 50-COSs are prepared from 90% and 50% deacetylated chitosan, cellular AChE activity is decreased with increasing concentration of 90-MMWCOS chitooligosaccharides in PC12 cell lines, the 90-COSs exhibit more potent AChE inhibitory activities compared to 50-COSs, while 90-MMWCOS, 1-5 kDa, in the 90COSs show the highest activity, overview
chlordiazepoxide HCl
-
reversible mixed-type inhibition
chlordiazepoxide HCl
-
-
chlorfenvinphos
P91954
-
Chloroquine
-
mixed type, 33% inhibition at 0.022 mM, 67% inhibition at 0.193 mM
chlorpyrifos
-
strong inhibition, used for active site titration
chlorpyrifos
-
a widely used organophosphorous pesticide, complete inhibition at 0.1 mM
chlorpyrifos
-
-
chlorpyrifos oxon
-
-
chlorpyrifos oxon
-
enzyme from Huanghua population is 62fold less sensitive than from Pingshan population
chlorpyrifos oxon
-
-
chlorpyrifos oxon
-
i.e. (O,O-diethyl O-(3,5,6-trichloro-2-pyridyl)) phosphate, an organophosphate
chlorpyrifos-oxon
-
complete inhibition of wild-type enzyme
choline
-
product inhibition, binding structure analysis
choline
-
product inhibition
choline
-
the activity decreases to 40% at 200 mM
cis-rosmarinic acid
-
from extracts of Melissa officinalis leaves
coroxon
F8QV18, -
-
coumaphos-oxon
-
-
-
coumaphos-oxon
P91954
-
-
coumarin 106
-
exhibits mixed-type AChE inhibition, targets a primary binding site at the active gorge and a secondary peripheral anionic binding site. Analysis of inhibitor binding, overview
Crotoxyphos
P91954
-
cryptotanshinone
-
mixed non-competitive inhibitor
cycloheptyl methylphosphonyl thiocholine
-
SP and RP enantiomers
cyclopentyl phenothiazine carbamate
-
-
cyclophostin
-
a natural AChE inhibitor
cyclosarin
-
detailed analysis of inhibition kinetics
cyclosarin
-
reactivation of sarin-inhibited acetylcholinesterase by oximes, 2-PAM, MMB4, HI-6, HLo-7, and ICD-585, overview
cyclosarin
-
a methylfluorophosphonate, enzyme reactivation by oximes, overview
cyclosarin
-
a nerve agent
cymserine
-
inhibition in the nanomolar range
dec-N-dimethylregeline
-
-
decamethonium
-
a reversible elongated gorge-spanning inhibitor, which bridges the two sites, the anionic subsite at the bottom of the active-site gorge and the peripheral anionic site at the entrance to the gorge
dehydroevodiamine hydrochloride
-
isolated from Evodia rutaecarpa
demeton
-
complete inhibition of wild-type enzyme
demeton-S-methyl
-
enzyme from Huanghua population is 2fold less sensitive than from Pingshan population
demeton-S-methyl
P91954
-
diazepam
-
reversible mixed-type inhibition
diazoxon
-
second order rate constant for inhibition is 420000 per M and min
Dichlorvos
Q95P20
insecticide
Dichlorvos
Q71SU5
50% inhibiton at 0.00059 mM
Dichlorvos
Q86GL8
50% inhibiton at 0.00058 mM
Dichlorvos
Q71SU7
50% inhibiton at 0.00056 mM
Dichlorvos
-
irreversible inhibition
Dichlorvos
-
in vivo inhibition in the brain, overview
Dichlorvos
P91954
-
dicrotophos
P91954
-
diethyl (2S)-2-((2-oxido-1,3,2-benzodioxaphosphol-2-yl)amino)pentanedioate
-
50% inhibition at 0.454 mM
diethyl (2S)-2-((2-oxido-1,3,2-benzodioxaphosphol-2-yl)amino)pentanedioate
-
50% inhibition at 1.226 mM
diethyl (2S)-2-((2-oxido-1,3,2-benzodioxaphosphol-2-yl)amino)succinate
-
50% inhibition at 0.651 mM
diethyl (2S)-2-((2-oxido-1,3,2-benzodioxaphosphol-2-yl)amino)succinate
-
50% inhibition at 0.577 mM
diethylfluorophosphate
-
-
diethyltabun
-
detailed analysis of inhibition kinetics
dihydrotanshinone
-
mixed non-competitive inhibitor
-
diisopropyl fluorophosphate
-
nerve agent, binding structure, overview
diisopropyl phosphofluoridate
-
complete inhibition of wild-type enzyme, not of mutant G122H/Y124Q/S125T
diisopropyl phosphorofluoridate
-
-
diisopropyl phosphorofluoridate
-
synthesis and evaluation of novel bis-pyridinium oximes as reactivators of DFP-inhibited acetylcholinesterase, overview. 1,3-Dimethoxymethyl benzene bis-[4,40-(hydroxyiminomethyl) pyridinium] dichloride and 1,4-dimethoxy but-2-ene bis-[4,40-(hydroxyiminomethyl) pyridinium] dichloride show high efficacy
diisopropylfluorophosphate
-
-
diisopropylfluorophosphate
-
-
diisopropylfluorophosphate
-
-
diisopropylfluorophosphate
-
-
diisopropylfluorophosphate
-
detailed analysis of inhibition kinetics
diisopropylfluorophosphate
B7X755
-
diisopropylfluorophosphate
-
-
Dimethoate
-
-
Dimethoate
-
affects the Km of the enzyme
dioxacarb
P91954
-
-
disodium calenduladiol disulfate
-
a semisynthetic derivative of calenduladiol, elicits higher AChE inhibition than this with 94.1% inhibition at 0.5 mM
donepezil
-
inhibition in the nanomolar range
donepezil
-
50% inhibition at 22 nM
donepezil
-
AChE activity in detergent soluble fraction of scopolamine amnesic mice is inhibited by donepezil, insulin and melatonin with varying extent in different brain regions, whereas AChE activity in salt soluble fraction is not much affected, overview
donepezil
-
7.9% inhibition at 0.025 mM
donepezil
-
enzyme binding structure, analysis using structure PDB ID 1EVE, detailed overview
donepezil
-
besides inhibiting the acetylcholinesterase donepezil can act as a therapeutic tool to accelerate angiogenesis in cardiovascular disease patients, overview
donepezil
-
donepezil concomitantly elevates VEGF expression in intracardiac endothelial cells of wild-type and alpha7 KO mice and further increases choline acetyltransferase protein expression, which is critical for acetylcholine synthesis in endothelial cells
donepizil
-
-
Echothiophate
-
99% inhibition of detergent-soluble enzyme activity at 0.001 mM, does not inhibit the soluble enzyme
Echothiophate
-
complete inhibition of wild-type enzyme, not of mutant G122H/Y124Q/S125T
edrophonium
-
-
edrophonium
-
-
edrophonium
-
-
edrophonium
-
-
edrophonium
-
a reversible active-site directed inhibitor, which interacts with the catalytic anionic subsite, at the bottom of the active-site gorge
edrophonium
B7X755
-
edrophonium
-
33.7% inhibition at 0.1 mM, competitive inhibition
edrophonium
-
-
edrophonium
-
the inhibitor binds specifically to the A-site of the enzyme
edrophonium chloride
-
-
epinorgalantamine
-
-
epinorgalanthamine
-
isolated from mother liquors/waste material obtained after industrial production of galanthamine hydrobromide from Leucojum aestivum leaves
eptastigmine
-
inhibition in the nanomolar range
eptastigmine
-
50% inhibition at 22 nM
eserine
-
slight inhibition
eserine
-
98% inhibition at 0.01 mM
eserine
-
90% inhibition of the gill microsomal enzyme after 30 min at 0.005 mM
eserine
-
0.01 mM, more than 97% inhibition
eserine
-
almost complete inhibition
eserine
Q71SU5
50% inhibiton at 0.00054 mM
eserine
Q86GL8
50% inhibiton at 0.0006 mM
eserine
Q71SU7
50% inhibiton at 0.0005 mM
eserine
-
0.001 mM, almost complete inhibition
eserine
-
isozyme AChE1A, complete competitive inhibition at 0.016 mM
eserine
-
20.1% inhibition at 0.1 mM
eserine
F8QV18, -
i.e. physostigamine
eserine sulfate
-
selective inhibitor
Ethidium bromide
-
uncompetitive inhibition at concentrations of 0.00625-0.1 mM in all brain regions except for the cerebellum where the inhibition is of a mixed-type
Ethidium bromide
-
-
ethiofencarb
P91954
-
Ethionamide
-
-
ethopropazine
-
partially
ethopropazine
-
-
ethopropazine
-
7% inhibition at 0.01 mM
ethopropazine
-
50% inhibition at 0.26 mM
ethopropazine
-
0.01 mM, about 57% inhibition
ethopropazine
-
about 5% inhibition at 0.001 mM
ethopropazine
B7X755
low inhibition
ethopropazine
-
-
ethopropazine
-
-
ethyl ((2-oxido-1,3,2-benzodioxaphosphol-2-yl)amino)acetate
-
50% inhibition at 0.626 mM
ethyl ((2-oxido-1,3,2-benzodioxaphosphol-2-yl)amino)acetate
-
50% inhibition at 0.460 mM
ethyl (2S)-2-((2-oxido-1,3,2-benzodioxaphosphol-2-yl)amino)-3-phenylpropanoate
-
50% inhibition at 0.332 mM
ethyl (2S)-2-((2-oxido-1,3,2-benzodioxaphosphol-2-yl)amino)-3-phenylpropanoate
-
50% inhibition at 0.406 mM
ethyl (2S)-2-((2-oxido-1,3,2-benzodioxaphosphol-2-yl)amino)hexanoate
-
50% inhibition at 0.321 mM
ethyl (2S)-2-((2-oxido-1,3,2-benzodioxaphosphol-2-yl)amino)hexanoate
-
50% inhibition at 0.506 mM
ethyl (2S)-2-((2-oxido-1,3,2-benzodioxaphosphol-2-yl)amino)propanoate
-
50% inhibition at 0.615 mM
ethyl (2S)-2-((2-oxido-1,3,2-benzodioxaphosphol-2-yl)amino)propanoate
-
50% inhibition at 0.537 mM
ethyl (2S)-3-methyl-2-((2-oxido-1,3,2-benzodioxaphosphol-2-yl)amino)butanoate
-
50% inhibition at 0.454 mM
ethyl (2S)-3-methyl-2-((2-oxido-1,3,2-benzodioxaphosphol-2-yl)amino)butanoate
-
50% inhibition at 0.394 mM
ethyl (2S)-3-methyl-2-((2-oxido-1,3,2-benzodioxaphosphol-2-yl)amino)pentanoate
-
50% inhibition at 0.345 mM
ethyl (2S)-3-methyl-2-((2-oxido-1,3,2-benzodioxaphosphol-2-yl)amino)pentanoate
-
50% inhibition at 0.387 mM
ethyl (2S)-4-(methylthio)-2-((2-oxido-1,3,2-benzodioxaphosphol-2-yl)amino)butanoate
-
50% inhibition at 0.386 mM
ethyl (2S)-4-(methylthio)-2-((2-oxido-1,3,2-benzodioxaphosphol-2-yl)amino)butanoate
-
50% inhibition at 0.551 mM
ethyl (2S)-4-amino-2-((2-oxido-1,3,2-benzodioxaphosphol-2-yl)amino)-4-oxobutanoate
-
50% inhibition at 0.420 mM
ethyl (2S)-4-amino-2-((2-oxido-1,3,2-benzodioxaphosphol-2-yl)amino)-4-oxobutanoate
-
50% inhibition at 0.385 mM
ethyl (2S)-4-methyl-2-((2-oxido-1,3,2-benzodioxaphosphol-2-yl)amino)pentanoate
-
50% inhibition at 0.196 mM
ethyl (2S)-4-methyl-2-((2-oxido-1,3,2-benzodioxaphosphol-2-yl)amino)pentanoate
-
50% inhibition at 0.427 mM
ethyl 5-amino-2-methyl-6,7,8,9-tetrahydrobenzo[b][1,8]naphthyridine-3-carboxylate
-
-
ethyl 5-[(dimethylcarbamoyl)oxy]-1-methyl-1,4-dihydroquinoline-3-carboxylate
-
-
ethyl 7-[(dimethylcarbamoyl)oxy]-1-methyl-1,4-dihydroquinoline-3-carboxylate
-
-
ethyl carbamate
-
-
ethyl N,N-di-isopropylphosphorofluoridate
-
-
ethyl N,N-di-n-propylphosphoamidocyanidate
-
-
ethyl N,N-diethylphosphorofluoridate
-
-
ethyl N-ethylphosphorofluoridate
-
-
ethyl N-methylphosphorofluoridate
-
-
ethyl N-n-propylphosphorofluoridate
-
-
ethyl [2-[(5aS,7R,9aS)-1-formyl-7-hydroxy-4-methoxy-6,7-dihydrodibenzo[b,d]furan-9a(5aH)-yl]ethyl]methylcarbamate
-
-
ethyl [2-[(5aS,7R,9aS)-7-hydroxy-1-(hydroxymethyl)-4-methoxy-6,7-dihydrodibenzo[b,d]furan-9a(5aH)-yl]ethyl]methylcarbamate
-
-
ethylsarin
-
a methylfluorophosphonate, enzyme reactivation by oximes, overview
ethylsarin
-
-
Eugenol
-
IC50 is 0.48 mg/ml
famphur-O
P91954
-
-
faradiol
-
a pentacyclic triterpene, isolated the ethanolic extract of Chuquiraga erinacea D. Don. subsp. erinacea leaves
fasciculin
-
-
-
fasciculin
-
inhibits catalysis peripherally by sealing the mouth of the active center gorge
-
fasciculin
-
-
-
fasciculin
-
binds at the mouth of the gorge, decreases the mobility of reporter groups attached to L76C and Y124C, increases the mobility of reporter groups attached to E81C and E84C
-
fasciculin-2
-
potent inhibitor
-
fenamiphos
-
detailed analysis of inhibition kinetics
fenamiphos
-
a phosphoramidate, no reactivation by oximes
fenamiphos
-
an organophosphorous-based insecticide, binding structure, overview
fenamiphos
-
an organophosphorus compound and insecticide
fenitrothion
-
i.e. O,O-dimethyl-O-(3-methyl-4-nitrophenyl) phosphorothioate, 50% inhibition at 394 mM
fenitrothion
-
i.e. O,O-dimethyl-O-(3-methyl-4-nitrophenyl) phosphorothioate, 50% inhibition at 366 mM
fenobucarb
P91954
-
fospirate
P91954
-
-
FP-biotin
-
i.e. 10-(fluoroethoxyphosphinyl)-N-(biotinamidopentyl)decanamide, second order rate constant for inhibition is 18000000 per M and min
fuel oil
-
considering the complex composition of fuel oil, it is difficult to attribute the effects to specific substances
-
galantamine
-
inhibition in the nanomolar range
galantamine
-
-
galanthamine
-
mixed type inhibition
galanthamine
-
50% inhibition at 800 nM
galanthamine
-
-
galanthamine
-
; isolated from mother liquors/waste material obtained after industrial production of galanthamine hydrobromide from Leucojum aestivum leaves
galanthamine
-
a competitive and reversible, specific inhibitor, crosses the blood brain barrier, significantly increases brain cholinergic network activity
galanthamine
P04058
-
galanthamine
-
inhibits also butyrylcholinesterase
galanthamine
-
a naturally occurring alkaloid and a drug for the treatment of mild to moderate Alzheimer's disease
galanthamine
-
-
galanthamine
-, D2U6X5, D2U6X6
;
galanthamine
-, P91954
-
gallamine
-
inhibition by gallamine follows the steric blockade hypothesis, i.e. only substrate association to as well as substrate-product dissociation from the active site were reduced in the presence of the inhibitor
gamma-terpinen
-
isolated from Melaleuca atlernifolia
giganteone C
-
a dimeric acylphenol isolated from ethyl acetate and methanol extracts from the leaves and the fruits of Myristica crassa, structure analysis by mass spectrometry
gnidioidine
-
isolated from ethanolic extracts of Lycopodium annotinum ssp. alpestre
H2O2
-
1 mM significantly inhibits, 0.001 mM increases activity 2fold
H2O2
-
soluble isoform, 0.006 mM, 2.5fold increase in Km-value, at 0.6 mM, complete inhibition. Membrane isoform, activation at small concentrations, inhibition at higher concentrations, but also depending on substrate concentration
heliantriol B2
-
a pentacyclic triterpene, isolated the ethanolic extract of Chuquiraga erinacea D. Don. subsp. erinacea leaves
heptenophos
-
-
-
heptenophos
P91954
-
-
heptylene-bis-tacrine
-
-
-
heptylene-bis-tacrine
P91954
-
-
hexamethonium
-
-
homoproaporphine
-
-
-
hostasine
-
a benzylphenethylamine alkaloid from Hosta plantaginea
huperzine
-
binds at the base of the active site gorge, has no effect on the mobility of reporter groups attached to L76C and Y124C, increases the mobility of reporter groups attached to E81C and E84C
huperzine
-
inhibition in the nanomolar range
huperzine A
-
50% inhibition above 47 nM
huperzine A
-
reversible inhibition, effects of pre-inhibition by physostigmine, pyridostigmine and huperzine A on inhibition by paraoxon, overview
huperzine A
-
reversible inhibition
huperzine A
-
linear mixed inhibition of AChE
huperzine A
-
a reversible AChE inhibitor
huperzine B
-
reversible
hydralazine HCl
-
reversible mixed-type inhibition
hyrcamine
-
isolated from Buxus hyrcana
hyrcanone
-
isolated from Buxus hyrcana
hyrcatrienine
-
isolated from Buxus hyrcana
infractopicrin
-
isolated from Cortinarius infractus, inhibits acetylcholinesterase, but does not inhibit butyrylcholinesterase
Insulin
-
AChE activity in detergent soluble fraction of scopolamine amnesic mice is inhibited by donepezil, insulin and melatonin with varying extent in different brain regions, whereas AChE activity in salt soluble fraction is not much affected, overview
-
interferon-beta
-
mechanisms of action of IFN-b is through the inhibition of AChE activity, overview
-
iolantamine iodomethylate
-
-
iso-butylsarin
-
a methylfluorophosphonate, enzyme reactivation by oximes, overview
iso-ompa
-
50% inhibition at 0.034 mM
iso-ompa
-
very poor inhibitor
iso-pentylsarin
-
-
isocorydine
-
-
-
isolariin A
-
isolated from Linaria reflexa
isolariin B
-
isolated from Linaria reflexa
isoprocarb
P91954
-
-
isopropyl methylphosphonyl thiocholine
-
SP and RP enantiomers
isoquinolin-1-yl(2-methoxyphenyl)methanol
-
-
isosorbide di-(2-chlorobenzoate)
-
-
isosorbide di-(3-chlorobenzoate)
-
-
isosorbide di-(4-bromobenzoate)
-
-
isosorbide di-(4-chlorobenzoate)
-
-
kesselridine iodomethylate
-
-
L-aspartate
-
inhibitory above 2.8 mM
L-phenylalanine
-
inhibitory above 0.14 mM
lannotinidine D
-
isolated from ethanolic extracts of Lycopodium annotinum ssp. alpestre
lawsaritol
-
isolated from Haloxylon recurvum
leufolin A
-
isolated from Leucas urticifolia
leufolin B
-
isolated from Leucas urticifolia
lidocain
-
-
linalool
-
weak in vitro inhibition
linalool
-
isolated from Thymus vulgaris essential oil
lovastatin
-
reversible mixed-type inhibition
lupeol
-
a pentacyclic triterpene, isolated the ethanolic extract of Chuquiraga erinacea D. Don. subsp. erinacea leaves
luteidine iodomethylate
-
-
lycodoline
-
isolated from ethanolic extracts of Lycopodium annotinum ssp. alpestre
lycofoline
-
isolated from ethanolic extracts of Lycopodium annotinum ssp. alpestre
lycoparin C
-
an alkaloid from Lycopodium casuarinoides, NMR structure determination and analysis, overview
lycoposerramine M
-
isolated from ethanolic extracts of Lycopodium annotinum ssp. alpestre
lycorine
-
isolated from mother liquors/waste material obtained after industrial production of galanthamine hydrobromide from Leucojum aestivum leaves
m-(N,N,N-trimethylammonio)-trifluoroacetophenone
-
binding structure analysis
mahanimbine
-
i.e. 3, 5-dimethyl-3-(4-methylpent-3-enyl)-11H-pyrano [5,6-a] carbazole, IC50 is 0.03 g/ml, isolated from the petroleum ether extract of the leaves of Murraya koenigii, an Indian medical plant
maingayone A
-
a dimeric acylphenol isolated from ethyl acetate and methanol extracts from the leaves and the fruits of Myristica crassa, structure analysis by mass spectrometry
-
maingayone B
-
a dimeric acylphenol isolated from ethyl acetate and methanol extracts from the leaves and the fruits of Myristica crassa, structure analysis by mass spectrometry
maingayone C
-
a dimeric acylphenol isolated from ethyl acetate and methanol extracts from the leaves and the fruits of Myristica crassa, structure analysis by mass spectrometry
malabaricone B
-
isolated from ethyl acetate and methanol extracts from the leaves and the fruits of Myristica crassa, structure analysis by mass spectrometry
malabaricone C
-
isolated from ethyl acetate and methanol extracts from the leaves and the fruits of Myristica crassa, structure analysis by mass spectrometry
malaoxon
Q95P20
insecticide
malathion
-
-
Melatonin
-
AChE activity in detergent soluble fraction of scopolamine amnesic mice is inhibited by donepezil, insulin and melatonin with varying extent in different brain regions, whereas AChE activity in salt soluble fraction is not much affected, overview
Melissa officinalis leaf extract
-
most of the fractions show inhibitory activity and are more potent than the extract due to antagonistic and synergistic effects between various constituents within the plant extract, mass spectrometric analysis of the inhibitory extract fractions, overview
-
metamidophos
-
easy reactivation by oximes
methamidophos
-
-
methamidophos
-
detailed analysis of inhibition kinetics
methamidophos
-
an organophosphorous-based insecticide, binding structure, overview
methanol
-
inhibitory above 0.14 mM
methiocarb
P91954
-
methomyl
P91954
-
methotrexate
-
-
methyl (2R,5R)-5-[(benzyloxy)methyl]-2-methoxy-7-methyl-2,3,4,5-tetrahydro-1,2-oxaphosphepine-6-carboxylate 2-oxide
-
-
methyl (2S,5R)-5-[(benzyloxy)methyl]-2-methoxy-7-methyl-2,3,4,5-tetrahydro-1,2-oxaphosphepine-6-carboxylate 2-oxide
-
-
methyl (3-{4-[({[5-(dimethylamino)naphthalen-1-yl]sulfonyl}amino)methyl]-1H-1,2,3-triazol-1-yl}propyl)phosphonofluoridate
-
-
methyl (3-{4-[({[6-(diethylamino)-2-oxo-2H-chromen-3-yl]carbonyl}amino)methyl]-1H-1,2,3-triazol-1-yl}propyl)phosphonofluoridate
-
-
methyl (4-{4-[({[5-(dimethylamino)naphthalen-1-yl]sulfonyl}amino)methyl]-1H-1,2,3-triazol-1-yl}butyl)phosphonofluoridate
-
-
methyl (4-{4-[({[6-(diethylamino)-2-oxo-2H-chromen-3-yl]carbonyl}amino)methyl]-1H-1,2,3-triazol-1-yl}butyl)phosphonofluoridate
-
-
methyl 1-methoxy-5-methyl-1,2,3,6-tetrahydrophosphinine-4-carboxylate 1-oxide
-
-
methyl 2-acetyl-4-(dimethoxyphosphoryl)butanoate
-
-
methyl 2-acetyl-5-(dimethoxyphosphoryl)pent-4-enoate
-
-
methyl 2-acetyl-5-(dimethoxyphosphoryl)pentanoate
-
-
methyl 2-methoxy-7-methyl-2,3,4,5-tetrahydro-1,2-oxaphosphepine-6-carboxylate 2-oxide
-
-
methyl 5-[(dimethylcarbamoyl)oxy]-1-methyl-1,4-dihydroquinoline-3-carboxylate
-
-
methyl 5-[(ethylcarbamoyl)oxy]-1-methyl-1,4-dihydroquinoline-3-carboxylate
-
-
Methyl paraoxon
-
reversible binding to a site on acetylcholinesterase distinct from the active site reduces their subsequent capacity to phosphorylate the active site, probably by steric hindrance or allosteric modification of the active site
methyl [3-(4-{[(4-{(E)-[4-(dimethylamino)phenyl]diazenyl}benzoyl)amino]methyl}-1H-1,2,3-triazol-1-yl)propyl]phosphonofluoridate
-
-
methyl [3-(4-{[(pyren-2-ylsulfonyl)amino]methyl}-1H-1,2,3-triazol-1-yl)propyl]phosphonofluoridate
-
-
methyl [4-(4-{[(4-{(E)-[4-(dimethylamino)phenyl]diazenyl}benzoyl)amino]methyl}-1H-1,2,3-triazol-1-yl)butyl]phosphonofluoridate
-
-
methyl [4-(4-{[(pyren-2-ylsulfonyl)amino]methyl}-1H-1,2,3-triazol-1-yl)butyl]phosphonofluoridate
-
-
methyl {3-[4-({[(6-methoxy-2-oxo-2H-chromen-3-yl)carbonyl]amino}methyl)-1H-1,2,3-triazol-1-yl]propyl}phosphonofluoridate
-
-
methyl {4-[4-({[(6-methoxy-2-oxo-2H-chromen-3-yl)carbonyl]amino}methyl)-1H-1,2,3-triazol-1-yl]butyl}phosphonofluoridate
-
-
methylorganophosphonates
-
the Sp-enantiomer is more reactive
-
methylsarin
-
a methylfluorophosphonate, enzyme reactivation by oximes, overview
methylsarin
-
-
methylsulfomethylate-O-ethyl-S-2-ethylmercaptoethyl methylthiophosphanate
-
Gd-42, selective inhibitor for acetylcholine esterase
-
metrifonate
-
inhibition in the nanomolar range
metrifonate
P91954
-
mevinphos
P91954
-
mexacarbate
-
-
-
mexacarbate
P91954
-
-
Monocrotophos
Nephotettix cincticeps Uhler
-
N-methyl carbamate-resistant strain is 65fold more sensitive than susceptible strain
N'-[(1E)-1-(4-hydroxyphenyl)ethylidene]-2-(2-nitrophenoxy)acetohydrazide
-
-
N,N'-bis(3-pyridin-3-ylcyclohexyl)pentanediamide
-
pKi-values and comparison with inhibitory effect on horse and Berrytheutis magister butyrylcholinesterase EC 3.1.1.8
N,N,N,N',N',N'-hexamethylbutane-1,4-diaminium
-
pKi-values and comparison with inhibitory effect on horse and Berrytheutis magister butyrylcholinesterase EC 3.1.1.8
N,N,N-trimethyl-10-(methylsulfonylthio)decan-1-aminium bromide
-
i.e. AMTS10, causes a degree of apparently irreversible of the AChE activity in erythrocytes
N,N,N-trimethyl-10-(methylsulfonylthio)decan-1-aminium bromide
-
i.e. AMTS10, irreversibly inhibits over 87% of the AChE activity in greenbug extracts
N,N,N-trimethyl-11-(methylsulfonylthio)undecan-1-aminium bromide
-
i.e. AMTS11, causes a degree of apparently irreversible of the AChE activity in erythrocytes
N,N,N-trimethyl-11-(methylsulfonylthio)undecan-1-aminium bromide
-
i.e. AMTS11, irreversibly inhibits over 87% of the AChE activity in greenbug extracts
N,N,N-trimethyl-12-(methylsulfonylthio)dodecan-1-aminium bromide
-
i.e. AMTS12, causes a degree of apparently irreversible of the AChE activity in erythrocytes
N,N,N-trimethyl-12-(methylsulfonylthio)dodecan-1-aminium bromide
-
i.e. AMTS12, irreversibly inhibits over 87% of the AChE activity in greenbug extracts
N,N,N-trimethyl-13-(methylsulfonylthio)tridecan-1-aminium bromide
-
i.e. AMTS13, causes a degree of apparently irreversible of the AChE activity in erythrocytes. AMTS13 at 0.006 mM leads to 43% inhibition after 1 h, 70% after 6 h, and 78% after 16 h
N,N,N-trimethyl-13-(methylsulfonylthio)tridecan-1-aminium bromide
-
i.e. AMTS13, irreversibly inhibits over 87% of the AChE activity in greenbug extracts
N,N,N-trimethyl-14-(methylsulfonylthio)tetradecan-1-aminium bromide
-
i.e. AMTS14, causes a degree of apparently irreversible of the AChE activity in erythrocytes
N,N,N-trimethyl-14-(methylsulfonylthio)tetradecan-1-aminium bromide
-
i.e. AMTS14, irreversibly inhibits over 87% of the AChE activity in greenbug extracts
N,N,N-trimethyl-15-(methylsulfonylthio)pentadecan-1-aminium bromide
-
i.e. AMTS15, causes a degree of apparently irreversible of the AChE activity in erythrocytes
N,N,N-trimethyl-15-(methylsulfonylthio)pentadecan-1-aminium bromide
-
i.e. AMTS15, irreversibly inhibits over 87% of the AChE activity in greenbug extracts
N,N,N-trimethyl-16-(methylsulfonylthio)hexadecan-1-aminium bromide
-
i.e. AMTS16, causes a degree of apparently irreversible of the AChE activity in erythrocytes
N,N,N-trimethyl-16-(methylsulfonylthio)hexadecan-1-aminium bromide
-
i.e. AMTS16, irreversibly inhibits over 87% of the AChE activity in greenbug extracts
N,N,N-trimethyl-17-(methylsulfonylthio)heptadecan-1-aminium bromide
-
i.e. AMTS17, a Cys-targeting methanethiosulfonate molecule, causes over 80% irreversible inhibition, under conditions that spare the human enzyme
N,N,N-trimethyl-17-(methylsulfonylthio)heptadecan-1-aminium bromide
-
i.e. AMTS17, a Cys-targeting methanethiosulfonate molecule, causes 95% irreversible inhibition, under conditions that spare the human enzyme
N,N,N-trimethyl-17-(methylsulfonylthio)heptadecan-1-aminium bromide
-
i.e. AMTS17, a Cys-targeting methanethiosulfonate molecule, causes irreversible inhibition, under conditions that spare the human enzyme
N,N,N-trimethyl-17-(methylsulfonylthio)heptadecan-1-aminium bromide
-
i.e. AMTS17, a Cys-targeting methanethiosulfonate molecule, causes over 80% irreversible inhibition, under conditions that spare the human enzyme
N,N,N-trimethyl-17-(methylsulfonylthio)heptadecan-1-aminium bromide
-
i.e. AMTS17, a Cys-targeting methanethiosulfonate molecule, causes irreversible inhibition, under conditions that spare the human enzyme
N,N,N-trimethyl-17-(methylsulfonylthio)heptadecan-1-aminium bromide
-
i.e. AMTS17, irreversibly inhibits 99% of the AChE activity in greenbug extracts, AChE species-selectivity
N,N,N-trimethyl-18-(methylsulfonylthio)octadecan-1-aminium bromide
-
i.e. AMTS18, a Cys-targeting methanethiosulfonate molecule, causes over 80% irreversible inhibition, under conditions that spare the human enzyme
N,N,N-trimethyl-18-(methylsulfonylthio)octadecan-1-aminium bromide
-
i.e. AMTS18, a Cys-targeting methanethiosulfonate molecule, causes 95% irreversible inhibition, under conditions that spare the human enzyme
N,N,N-trimethyl-18-(methylsulfonylthio)octadecan-1-aminium bromide
-
i.e. AMTS18, a Cys-targeting methanethiosulfonate molecule, causes irreversible inhibition, under conditions that spare the human enzyme
N,N,N-trimethyl-18-(methylsulfonylthio)octadecan-1-aminium bromide
-
i.e. AMTS18, a Cys-targeting methanethiosulfonate molecule, causes over 80% irreversible inhibition, under conditions that spare the human enzyme
N,N,N-trimethyl-18-(methylsulfonylthio)octadecan-1-aminium bromide
-
i.e. AMTS18, a Cys-targeting methanethiosulfonate molecule, causes irreversible inhibition, under conditions that spare the human enzyme
N,N,N-trimethyl-18-(methylsulfonylthio)octadecan-1-aminium bromide
-
i.e. AMTS18, irreversibly inhibits 99% of the AChE activity in greenbug extracts, AChE species-selectivity
N,N,N-trimethyl-19-(methylsulfonylthio)nonadecan-1-aminium bromide
-
i.e. AMTS19, irreversibly inhibits 99% of the AChE activity in greenbug extracts, AChE species-selectivity
N,N,N-trimethyl-2-oxo-3-(7-oxo-7H-dibenzo[de,h]quinolin-9-yl)propan-1-aminium
-
-
N,N,N-trimethyl-20-(methylsulfonylthio)eicosan-1-aminiumbromi de
-
i.e. AMTS20, irreversibly inhibits 99% of the AChE activity in greenbug extracts, AChE species-selectivity
N,N,N-trimethyl-3-oxo-4-(7-oxo-7H-dibenzo[de,h]quinolin-9-yl)butan-1-aminium
-
-
N,N,N-trimethyl-4-oxo-5-(7-oxo-7H-dibenzo[de,h]quinolin-9-yl)pentan-1-aminium
-
-
N,N,N-trimethyl-7-(methylsulfonylthio)heptan-1-aminium bromide
-
i.e. AMTS7, causes weak and purely reversible inhibition of AChE activity in erythrocytes
N,N,N-trimethyl-7-(methylsulfonylthio)heptan-1-aminium bromide
-
i.e. AMTS7, irreversibly inhibits over 87% of the AChE activity in greenbug extracts
N,N,N-trimethyl-8-(methylsulfonylthio)octan-1-aminium bromide
-
i.e. AMTS8, causes weak and purely reversible inhibition of AChE activity in erythrocytes
N,N,N-trimethyl-8-(methylsulfonylthio)octan-1-aminium bromide
-
i.e. AMTS8, irreversibly inhibits over 87% of the AChE activity in greenbug extracts
N,N,N-trimethyl-9-(methylsulfonylthio)nonan-1-aminium bromide
-
i.e. AMTS9, causes weak and purely reversible inhibition of AChE activity in erythrocytes
N,N,N-trimethyl-9-(methylsulfonylthio)nonan-1-aminium bromide
-
i.e. AMTS9, irreversibly inhibits over 87% of the AChE activity in greenbug extracts
N,N,N-trimethylmethanaminium
-
pKi-values and comparison with inhibitory effect on horse and Berrytheutis magister butyrylcholinesterase EC 3.1.1.8
N,N-Diisopropylphosphorodiamidic anhydride
-
weak
N,N-dimethyl phosphoramidic acid bis-(4-chlorophenyl) ester
-
binding activity and lipophilicity, overview
N,N-dimethyl phosphoramidic acid bis-(4-methylphenyl) ester
-
binding activity and lipophilicity, overview
N,N-dimethyl phosphoramidic acid bis-phenyl ester
-
binding activity and lipophilicity, overview
N-((4S,5S,7R)-2-[7-(1-benzylpiperidin-4-yl)]carbamoyl-5-hydroxy-2-methyloct-4-yl)-5-[methyl(methylsulfonyl)amino]-N'-[(R)-1-phenyl ethyl]isophthalamide
-
48.7% inhibition at 0.025 mM
N-((4S,5S,7R)-2-[7-(1-benzylpiperidin-4-yl)]carbamoyl-5-hydroxy-2-methyloct-4-yl)-N'-[(R)-1-(4-fluorophenyl)ethyl]-5-[methyl(methylsulfonyl)amino]isophthalamide
-
47.5% inhibition at 0.025 mM
N-((4S,5S,7R)-2-[7-(1-benzylpiperidin-4-yl)]ethylcarbamoyl-5-hydroxy-2-methyloctan-4-yl)-N'-[(R)-1-(4-fluorophenyl)ethyl]-5-[methyl(methylsulfonyl)amino]isophthalamide
-
23.8% inhibition at 0.025 mM
N-((4S,5S,7R)-2-[7-(1-benzylpiperidin-4-yl)]methylcarbamoyl-5-hydroxy-2-methyloct-4-yl)-N'-[(R)-1-(4-fluorophenyl)ethyl]-5-[methyl(methylsulfonyl)amino]isophthalamide
-
45.9% inhibition at 0.025 mM
N-((4S,5S,7R)-2-[7-(4-benzylpiperazin-1-yl)]carbamoyl-5-hydroxy-2-methyloct-4-yl)-5-[methyl(methylsulfonyl)amino]-N'-[(R)-1-phenylethyl]isophthalamide
-
5.2% inhibition at 0.025 mM
N-(14-methylallyl)norgalanthamine
-
isolated from mother liquors/waste material obtained after industrial production of galanthamine hydrobromide from Leucojum aestivum leaves, structure determination by NMR spectroscopy
N-(2-phenylethyl)-N-[(12Z)-7,8,9,10-tetrahydroazepino [2,1b]quinazolin-12(6H)-ylidene]amine
-
-
N-(2-[4-[(5,6-dimethoxy-2,3-dihydro-1H-inden-2-yl)methyl]piperidin-1-yl]ethyl)-1,2,3,4-tetrahydroacridin-9-amine
-
-
N-(3-[4-[(5,6-dimethoxy-2,3-dihydro-1H-inden-2-yl)methyl]piperidin-1-yl]propyl)-1,2,3,4-tetrahydroacridin-9-amine
-
-
N-([2S,3(R,S)]-2-[4-(1-benzylpiperidin-4-yl)]ethyl-carbamoyl-3-hydroxy-1-phenylbut-2-yl)-5-[methyl-(methylsulfonyl)amino]-N'-[(R)-1-phenylethyl]isophthalamide
-
-
N-([2S,3(R,S)]-2-[4-(1-benzylpiperidin-4-yl)]ethylcarbamoyl-3-hydroxy-1-phenylbut-2-yl)-N',N'-dipropyl-5-nitroisophthalamide
-
-
N-([2S,3(R,S)]-2-[4-(1-benzylpiperidin-4-yl)]ethylcarbamoyl-3-hydroxy-1-phenylbut-2-yl)-N'-[(R)-1-(4-fluorophenyl)ethyl]-5-[methyl(methylsulfonyl)amino]iso phthalamide
-
-
N-allylnorgalanthamine
-
isolated from mother liquors/waste material obtained after industrial production of galanthamine hydrobromide from Leucojum aestivum leaves, structure determination by NMR spectroscopy
N-benzoyl N',N'-(tert-butybenzyl) phosphoramidic chloride
-
26% reactivation of enzyme activity by pralidoxime, 4% by obidoxime
N-benzoyl N',N'-(tert-butybenzyl) thiophosphoramidic chloride
-
22% reactivation of enzyme activity by pralidoxime, 3% by obidoxime
n-butanol
-
inhibits below 100 mM and activates above 100 mM
n-butylsarin
-
a methylfluorophosphonate, enzyme reactivation by oximes, overview
n-butylsarin
-
-
N-desmethyl-8alpha-ethoxypretazzettine
-
-
N-desmethyl-8beta-ethoxypretazzettine
-
-
N-ethylmaleimide
P04058
inactivation
N-methyl,N-alkyl carbamates
-
AChE inhibition is mainly determined by the size of the N-alkyl substituent and to a lesser extent by the nature of the leaving group, Ki was highest when the alkyl is methyl, hexyl, cyclohexyl, or an aromatic substituent and lowest when it is ethyl, ki depends on a delicate balance between the length of the residue and its degree of freedom of rotation, overview
-
N-methyl-3-pyridin-3-ylcyclohexanamine
-
pKi-values and comparison with inhibitory effect on horse and Berrytheutis magister butyrylcholinesterase EC 3.1.1.8
N-methyl-N-(3-carbamoyloxyphenyl)methyl-amino inhibitor
-
-
N-methylstepholidine
-
-
N-methylwaltherione
-
an alkaloid isolated from Waltheria brachypetala
n-pentylsarin
-
-
n-propylsarin
-
a methylfluorophosphonate, enzyme reactivation by oximes, overview
n-propylsarin
-
-
N-[di(morpholin-4-yl)phosphoryl]-4-methylbenzamide
-
-
N-[di(morpholin-4-yl)phosphoryl]benzamide
-
-
N3-demethylsaracodine
-
-
narwedine
-
isolated from mother liquors/waste material obtained after industrial production of galanthamine hydrobromide from Leucojum aestivum leaves
Nb-dimethylcycloxobuxoviricine
-
isolated from Buxus hyrcana
neo-pentylsarin
-
-
Neostigmine
-
-
Neostigmine
-
about 60% inhibition at 0.02 mM
Neostigmine
-
50% inhibition at 0.56 nM
Neostigmine
-
covalent, slow, and reversible inhibition
Neostigmine
-
31.1% inhibition at 0.1 mM
Neostigmine
-, P91954
-
neostigmine bromide
-
competitive
neostigmine bromide
-
competitive
neostigmine bromide
-
weak inhibition
neostigmine methylsulfate
-
painkiller
nifedipine
-
reversible mixed-type inhibition
norsanguinine
-
-
O-ethyl S-(2-(diisopropylamino)ethyl) methylphosphonothioate
-
i.e. VX, detailed analysis of inhibition kinetics
O-ethyl S-2-N,N-diisopropylaminoethyl methylphosphonothiolate
-
reactivation of sarin-inhibited acetylcholinesterase by oximes, 2-PAM, MMB4, HI-6, HLo-7, and ICD-585, overview
O-ethyl-O-(4-nitrophenyl)-phenylphosphonothioate
-
-
O-ethyl-S-pentyl methylthiophosphonate
-
LG-64
O-isobutyl S-2-N,N-diethylaminoethyl methylphosphonothiolate
-
reactivation of sarin-inhibited acetylcholinesterase by oximes, 2-PAM, MMB4, HI-6, HLo-7, and ICD-585, overview
O-isopropyl methylphosphonofluoridate
-
i.e. sarin, a nerve agent, leads to irrversible inhibition of AChE
O-isopropylmethylphosponofluoridate
-
-
-
O-methylmaritidine
-
-
O-O-dimethyl-O-(2,2-dichlorovinyl)phosphate
-
phosphorylates the active site serine
O-pinacolyl methylphosphonofluoridate
-
i.e. soman, a nerve agent, leads to irrversible inhibition of AChE
O-pinacolylmethylphophonofluoridate
-
-
-
octahydro-2H-quinolizin-1-yl octahydro-2H-quinolizin-1-ylmethyl butanedioate
-
pKi-values and comparison with inhibitory effect on horse and Berrytheutis magister butyrylcholinesterase EC 3.1.1.8
octahydro-2H-quinolizin-1-ylmethanol
-
pKi-values and comparison with inhibitory effect on horse and Berrytheutis magister butyrylcholinesterase EC 3.1.1.8
omethoate
P91954
-
organophosphorus compounds
-
determination of reactivation efficiency with oxims, e.g. obixime, 2-PAM, HI 6, HLŲ 7, and MMB-4, reactivation kinetics, overview, structure-activity relationship for inhibition and spontaneous reactivation, overview
-
oxazaphenalene lactone
-
-
oxidized malathion
-
50% inhibition at 0.216 mM
oxidized malathion
-
50% inhibition at 0.203 mM
oxidized malathion
-
50% inhibition at 0.248 mM
oxidized triazophos
-
50% inhibition at 0.043 mM
oxidized triazophos
-
50% inhibition at 0.036 mM
oxidized triazophos
-
50% inhibition at 0.043 mM
oxoxylopine
-
-
-
oxydemeton methyl
-
-
-
oxydemeton methyl
P91954
-
-
p-Carboxyphenyltrimethylammonium iodide
-
p-quat
paracetamol/caffeine
-
painkiller preparation
-
paracetamol/propifenazone/caffeine
-
painkiller preparation
-
Paraoxon
-
does not inhibit SS ChE, completely inhibits DS ChE at 1 mM
Paraoxon
-
26% inhibition at 0.0000001 mM, reversible binding to a site on acetylcholinesterase distinct from the active site reduces their subsequent capacity to phosphorylate the active site
Paraoxon
-
inhibits
Paraoxon
-
50% inhibition at 212.5 nM
Paraoxon
-
50% inhibition at 357 nM
Paraoxon
-
enzyme from Huanghua population is 1.6fold less sensitive than from Pingshan population
Paraoxon
-
irreversible inhibition, effects of pre-inhibition by physostigmine, pyridostigmine and huperzine A on inhibition by paraoxon, overview
Paraoxon
-
oxime-induced reactivation of the enzyme following inhibition by sarin or paraoxon, overview
Paraoxon
-
complete inhibition of wild-type enzyme, not of mutant G122H/Y124Q/S125T
Paraoxon
-
irreversible inhibition
Paraoxon
-
irreversible inhibition
Paraoxon
-
activity of cholinesterase reactivators pralidoxime, obidoxime, trimedoxime, methoxime and H-oxime HI-6, i.e. 1-(4-hydroxyiminomethylpyridinium)-3-(4-carbamoylpyridinium)-2-oxapropane dichloride, in reactivation of plasma AChE inhibited by pesticide paraoxon, efficacies, none of tested oximes surpassed 25% of AChE reactivation, overview
Paraoxon
-
-
Paraoxon
-
the inhibition gets irreversible due to aging, but is reversible before by oximes, pre-treatment with carbamates improves antidotal treatment substantially, high reversibility effects by pyridostigmine or physostigmine, overview
Paraoxon
-
i.e. O,O-diethyl-O-4-nitrophenyl phosphate, the paraoxon-inhibited enzyme is reactivated by several compounds, kinetics, overview. Best reactivating compounds are obidoxime, K027, and trimedoxie
Paraoxon
-
an organophosphate compound, a quasi-irreversible AChE inhibitor
Paraoxon
-, P91954
-
Paraoxon
F8QV18, -
-
paraoxon ethyl
-
-
paraoxon methyl
-
-
paraoxon-ethyl
-
detailed analysis of inhibition kinetics
paraoxon-ethyl
-
-
paraoxon-methyl
-
detailed analysis of inhibition kinetics
paraoxon-methyl
-
inhibition mechanism and reactivation of paraoxon-methyl-inhibited AChE by pyridine-2-aldoxime methochloride, overview
parathion
-
-
parathion
-
-
pentan-3-one-dibromide
-
BW284c51
-
phenserine
-
inhibition in the nanomolar range
phenserine
-
50% inhibition at 22 nM
phenyl 1,2-dimethylhydrazinecarboxylate
-
-
phenyl 1-methylhydrazinecarboxylate
-
-
phenyl butylcarbamate
-
-
phenyl phenothiazine carbamate
-
-
phenylcoumarin
-
-
phenylethylcymserine
-
50% inhibition at 0.03 mM
phenylmethylsulfonyl fluoride
-
about 60% inhibition at 0.5 mM
Phenylmethylsulfonylfluoride
-
-
Phenylmethylsulfonylfluoride
B7X755
-
Phosphamidon
P91954
-
phosphatidylserine
-
-
physostigmine
-
-
physostigmine
-
-
physostigmine
-
-
physostigmine
-
mechanism of inhibition
physostigmine
-
-
physostigmine
-
-
physostigmine
-
about 50% inhibition at 0.02 mM
physostigmine
-
inhibition in the nanomolar range
physostigmine
-
reversible inhibition, effects of pre-inhibition by physostigmine, pyridostigmine and huperzine A on inhibition by paraoxon, overview
physostigmine
-
; covalent, slow, and reversible inhibition
physostigmine
-
reversible inhibition
physostigmine
-
71.2% inhibition at 0.1 mg/ml
physostigmine
-
83-85% inhibition at 250 nM of erythrocyte and muscle enzymes, pre-inhibition of AChE with pyridostigmine or physostigmine results in a concentration-dependent increase in carbamylation, residual activity after soman inhibition and fraction of decarbamylation AChE after discontinuation of the inhibitors without differences between erythrocyte and muscle AChE
physostigmine
-
inhibits also butyrylcholinesterase
physostigmine
-
-
physostigmine
-
92.5% inhibition, IC50 is 0.0028 mg/ml
physostigmine
-
-
physostigmine
-, P91954
-
pilocarpine
-
pilocarpine induction of status epilepticus leads to enzyme inhibition during seizures in the rat brain, overview
pirimicarb
P91954
-
-
polyamidoamine dendrimer PAMAM G3.5
-
0.1 mM, 75% residual activity due to changes in enzyme conformation
-
polyamidoamine dendrimer PAMAM G4
-
0.1 mM, 40% residual activity due to changes in enzyme conformation
-
polyamidoamine dendrimer PAMAM-OH G4
-
0.1 mM, 85% residual activity due to changes in enzyme conformation
-
primaquine
-
mixed type, 33% inhibition at 0.038 mM, 67% inhibition at 0.247 mM
procainamide
B7X755
low inhibition
procaine hydrochloride
-
-
profenofos
P91954
-
promalabaricone B
-
-
promalabaricone C
-
-
promecarb
P91954
-
-
propidium
-
-
propidium
Q71SU5
50% inhibiton at 0.196 mM
propidium
Q86GL8
50% inhibiton at 0.114 mM
propidium
Q71SU7
50% inhibiton at 0.155 mM
propidium
-
a reversible peripheral anionic site inhibitor, which interacts with a site at the entrance to the gorge
propidium
-
the inhibitor binds specifically to the P-site of the enzyme
propidium iodide
P91954
-
propionylthioacetylcholine
-
-
Propionylthiocholine
Nephotettix cincticeps Uhler
-
N-methyl carbamate-resistant strain, no substrate inhibition up to 0.01 mM
Propionylthiocholine
-
substrate inhibition
Propionylthiocholine
B7X755
the recombinant carp AChE shows substrate inhibition at high substrate concentrations of acetyl- and propionylthiocholine
propoxur
Nephotettix cincticeps Uhler
-
N-methyl carbamate-resistant strain is 53fold less sensitive than susceptible strain
propoxur
-, D2U6X5, D2U6X6
i.e. 2-isopropoxyphenyl-N-methylcarbamate, complete inhibition at concentrations exceeding 100 nM; i.e. 2-isopropoxyphenyl-N-methylcarbamate, complete inhibition at concentrations exceeding 100 nM
propoxur
P91954
-
propyl phenothiazine carbamate
-
-
pyridine-2-aldoxime methochloride
-
inhibition mechanism
pyridostigmine
-
reversible inhibition, effects of pre-inhibition by physostigmine, pyridostigmine and huperzine A on inhibition by paraoxon, overview
pyridostigmine
-
reversible inhibition
pyridostigmine
-
pre-inhibition of AChE with pyridostigmine or physostigmine results in a concentration-dependent increase in carbamylation, residual activity after soman inhibition and fraction of decarbamylation AChE after discontinuation of the inhibitors without differences between erythrocyte and muscle AChE
pyridostigmine
-
6.1% inhibition at 0.1 mM
pyridostigmine
P91954
-
Quinidine
-
-
Quinine
-
mixed type, 33% inhibition at 3.2 mM, 67% inhibition at 7.5 mM
quinuclidinyl benzilate
-
-
regeline iodomethylate
-
-
remerine
-
-
-
rivastigmine
-
trade name: Exelon, carbamylates the enzyme, enzyme reactivates spontaneous at a slow rate
rivastigmine
-
trade name: Exelon, carbamylates the enzyme, enzyme reactivates spontaneously at a slow rate
rivastigmine
-
trade name: Exelon, carbamylates the enzyme, 10% spontaneous reactivation after 48 h
rivastigmine
-
50% inhibition at 0.048 mM
rivastigmine
-
50% inhibition at 4150 nM
rivastigmine
-
-
rosmarinic acid derivative
-
from extracts of Melissa officinalis leaves
-
RP cycloheptyl methylphosphonyl thiocholine
-
phosphonylates the enzyme, wild-type enzyme and mutant enzymes can only poorly be reactivated by 1-(2'-hydroxyiminomethyl-1'-pyridinium)-3-(4''-carbamoyl-1''-pyridinium)-2-oxapropane dichloride or 2-(hydroxyiminomethyl)-1-methylpyridinium iodide
RP-3,3-dimethylbutyl methylphosphonyl thiocholine
-
phosphonylates the enzyme, wild-type enzyme and mutant enzymes can only poorly be reactivated by 1-(2'-hydroxyiminomethyl-1'-pyridinium)-3-(4''-carbamoyl-1''-pyridinium)-2-oxapropane dichloride or 2-(hydroxyiminomethyl)-1-methylpyridinium iodide
RP-isopropyl methylphosphonyl thiocholine
-
phosphonylates the enzyme, wild-type enzyme and mutant enzymes can be partially reactivated by 1-(2'-hydroxyiminomethyl-1'-pyridinium)-3-(4''-carbamoyl-1''-pyridinium)-2-oxapropane dichloride or 2-(hydroxyiminomethyl)-1-methylpyridinium iodide
S-[2-(diisopropylamino)ethyl]-O-ethylmethylphosphonothioate
-
i.e. VX, a nerve agent, leads to irrversible inhibition of AChE
salignarine-C
-
isolated from Sarcococca saligna
sanguinine
-
-
sarcovagenine-C
-
isolated from Sarcococca saligna
sarin
-
detailed analysis of inhibition kinetics
sarin
-
oxime-induced reactivation of the enzyme following inhibition by sarin or paraoxon, overview
sarin
-
reactivation of sarin-inhibited acetylcholinesterase by oximes, 2-PAM, MMB4, HI-6, HLo-7, and ICD-585, overview
sarin
-
nerve agent, binding structure, overview
sarin
-
a methylfluorophosphonate, enzyme reactivation by oximes, overview
SDZ 212-712
-
optical isomer of rivastigmine
sec-pentylsarin
-
-
serpentine
-
isolated from aqueous extracts of Catharanthus roseus roots
serpentine
-
isolated from aqueous extracts of Catharanthus roseus roots, competitive blockade of muscarinic receptors with high efficiency
simvastatin
-
reversible mixed-type inhibition
slavin A
-
isolated from Salvia santolinifolia
slavin B
-
isolated from Salvia santolinifolia
sodium 5-amino-2-methyl-6,7,8,9-tetrahydrobenzo[b][1,8]naphthyridine-3-carboxylate
-
-
sodium dodecylsulfate
-
inhibition is partially prevented by addition of ethanol
Sodium fluoride
-
about 60% inhibition at 0.5 mM
soman
-
detailed analysis of inhibition kinetics
soman
-
reactivation of sarin-inhibited acetylcholinesterase by oximes, 2-PAM, MMB4, HI-6, HLo-7, and ICD-585, overview
soman
-
a methylfluorophosphonate, enzyme reactivation by oximes, overview
soman
-
inhibition with rapid aging of the inhibited enzyme, partial protection of the enzyme by reversible inhibition in case of soman exposure or of paraoxon inhibition, overview
soman
-
the inhibition gets irreversible due to aging, but is reversible before by oximes, pre-treatment with carbamates improves antidotal treatment substantially, high reversibility effects by pyridostigmine or physostigmine, overview
soman
-
pyridostigmine or physostigmine pre-treatment protects a critical level of muscle AChE from inhibition by soman
SP-3,3-dimethylbutyl methylphosphonyl thiocholine
-
phosphonylates the enzyme, wild-type enzyme and mutant enzymes can be partially reactivated by 1-(2'-hydroxyiminomethyl-1'-pyridinium)-3-(4''-carbamoyl-1''-pyridinium)-2-oxapropane dichloride or 2-(hydroxyiminomethyl)-1-methylpyridinium iodide
SP-cycloheptyl methylphosphonyl thiocholine
-
phosphonylates the enzyme, wild-type enzyme and mutant enzymes can be partially reactivated by 1-(2'-hydroxyiminomethyl-1'-pyridinium)-3-(4''-carbamoyl-1''-pyridinium)-2-oxapropane dichloride or 2-(hydroxyiminomethyl)-1-methylpyridinium iodide
SP-isopropyl methylphosphonyl thiocholine
-
phosphonylates the enzyme, wild-type enzyme and mutant enzymes can be partially reactivated by 1-(2'-hydroxyiminomethyl-1'-pyridinium)-3-(4''-carbamoyl-1''-pyridinium)-2-oxapropane dichloride or 2-(hydroxyiminomethyl)-1-methylpyridinium iodide
stephaoxocanidine
-
-
stepharotudine
-
-
-
succinyldicholine
-
substrate inhibition, binding structure analysis
t-butyl phenothiazine carbamate
-
-
Tabun
-
detailed analysis of inhibition kinetics
Tabun
-
a phosphoramidate, 16 derivatives, overview, no reactivation by oximes
Tabun
-
reactivation of sarin-inhibited acetylcholinesterase by oximes, 2-PAM, MMB4, HI-6, HLo-7, and ICD-585, overview
Tabun
-
an organophosphorous inhibitor
tacrine
-
inhibition in the nanomolar range
tacrine
-
50% inhibition at 190 nM
tacrine
-
a reversible active-site directed inhibitor, which interacts with the catalytic anionic subsite, at the bottom of the active-site gorge
tacrine
-
inhibits also butyrylcholinesterase
tacrine
-
a mixed-type inhibitor with a strong noncompetitive component, completely blocks deacylation of the acyl-enzyme
tacrine
-
i.e. 9-amino-1,2,3,4-tetrahydroacridine hydrochloride, 54.2% inhibition at 0.1 mM, mixed-type inhibition
tacrine
-, D2U6X5, D2U6X6
;
tacrine
-, P91954
-
taspine
-
isolated from Thymus vulgaris essential oil
tea polyphenol
-
up to 60% inhibition of enzyme
terpinen-4-ol
-
isolated from Melaleuca atlernifolia
terpinen-4-ol
-
IC50 is 3.2 mg/ml
tetracaine hydrochloride
-
-
tetrachlorvinphos
P91954
-
tetraethyl diphosphate
-
-
tetraethylpyrophosphate
-
-
-
tetraethylpyrophosphate
P91954
-
-
tetrahydropalmatine
-
-
Tetramethyl ammonium
-
-
tetra[monoisopropyl]pyrophosphortetramide
-
-
TFK+
-
analysis of the inhibition mechanism by ab initio quantum mechanical/molecular mechanical approach and classical molecular dynamics simulations, overview
TFK0
-
analysis of the inhibition mechanism by ab initio quantum mechanical/molecular mechanical approach and classical molecular dynamics simulations, overview
thalifoline
-
-
-
thioflavin T
-
the P-site-specific ligand inhibits the hydrolysis of the rapidly hydrolyzed substrate acetylthiocholine but fails to show any inhibition of the slowly hydrolyzed substrates 3-(acetamido)-N,N,N-trimethylanilinium and carbachol
-
thioflavin T
-
-
-
thioflavin T
P91954
-
-
thyme essential oil
-
-
-
thymohydroquinone
-
high in vitro inhibition, compound of the essential oil of Thymus vulgaris
thymohydroquinone
-
isolated from Thymus vulgaris essential oil
Thymol
-
in vitro inhibition, compound of the essential oil of Thymus vulgaris
Thymol
-
isolated from Thymus vulgaris essential oil
thymoquinone
-
in vitro inhibition, compound of the essential oil of Thymus vulgaris
thymoquinone
-
isolated from Thymus vulgaris essential oil
trans-anethole
-
isolated from the ethanolic extract from the fruits of Pimpinella anisoides
trans-rosmarinic acid
-
from extracts of Melissa officinalis leaves
triazophos oxon
-
-
trifluoroacetophenone
-
inhibits Y124C mutant slower than the wild-type enzyme
Trigonelline
-
-
Trimethyl(p-aminophenyl)ammonium chloride hydrochloride
-
-
Triton X-100
-
uncompetitive inhibition at 0.01%, below the critical micelle concentration, and above at concentration higher than 0.013%
True cholinesterase inhibitor
-
-
-
tubocurarine
-
a reversible peripheral anionic site inhibitor, which interacts with a site at the entrance to the gorge
ungeremine
-
-
Urea
-
the stability of the immobilized recombinant enzyme is 2.7fold increased compared to the soluble recombinant enzyme
VR
-
nerve agent
VX
-
i.e. O-ethyl S-2-isopropylaminoethyl methylphosphonothiolate, nerve agent, binding structure, overview
VX
-
i.e. S-[2-(diisopropylamino)ethyl]-O-ethylmethylphosphonothionate, a nerve agent
VX
-
a nerve agent
VX
-
pseudo-irreversible inhibition
waltherine
-
an alkaloid isolated from Waltheria brachypetala, 51.4% inhibition at 0.1 mg/ml
waltherione-A
-
an alkaloid isolated from Waltheria brachypetala, Waltheria douradinha, Melochia chamaedrys, and Melochia odorata leaves
waltherione-B
-
an alkaloid isolated from Waltheria brachypetala
xanthostigmine
-
-
xanthostigmine
-
three-dimensional model of the quaternary complex between AChE and xanthostigmine
[1-(2-nitrophenyl)-2,2,2-trifluoroethyl]-arsenocholine iodide
-
caged compound, binding structure and mechanism with AChE, binding within the active-site gorge, overview
[4-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)phenyl]-(3,4-dimethoxyphenyl)methanone
-
-
Monocrotophos
P91954
-
additional information
-
-
-
additional information
-
no substrate inhibition up to 17 mM acetylcholine iodide
-
additional information
-
bimolecular rate konstant values for several inhibitors
-
additional information
-
inhibition of enzyme activity after exposure to cellular phone irradiation for more than 10 min. Irradiation induces formation of a enzyme hydrogel from the assembly of highly hydrated protein molecules
-
additional information
-
no substrate inhibition
-
additional information
-
comparison of reaction rates with human acetylcholinesterase EC 3.1.1.7 and butyrylcholinesterase EC 3.1.1.8 for several organophosphate inhibitors
-
additional information
-
no substrate inhibition by acetylthiocholine
-
additional information
-
proposed mechanism for enzyme inhibition by N-butylcarbamates and detailed kinetics of inhibition
-
additional information
-
comparison of 50% inhibitory concentration for EC 3.1.1.7 and EC 3.1.1.8
-
additional information
-
proposed inhibition mechanism for 1,3,2-benzodioxaphopholenes
-
additional information
-
structure-function relationship of inhibition, overview
-
additional information
-
the reactivation of nerve agent-inhibited acetylcholinesterase by oximes, 2-PAM, MMB4, HI-6, HLo-7, and ICD-585, is the most important step in the treatment of nerve agent poisoning, e.g. by G and V type nerve agents, reactivation kinetics, determination of the aging rate constants of nerve agent-inhibited AChE, overview
-
additional information
-
inhibition mechanism, overview
-
additional information
-
no inhibition by iso-OMPA
-
additional information
-
no inhibition by iso-OMPA