Information on EC 3.1.1.5 - lysophospholipase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea

EC NUMBER
COMMENTARY
3.1.1.5
-
RECOMMENDED NAME
GeneOntology No.
lysophospholipase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate
show the reaction diagram
-
-
-
-
PATHWAY
KEGG Link
MetaCyc Link
Glycerophospholipid metabolism
-
phosphatidylcholine resynthesis via glycerophosphocholine
-
phospholipid remodeling (phosphatidylethanolamine, yeast)
-
SYSTEMATIC NAME
IUBMB Comments
2-lysophosphatidylcholine acylhydrolase
-
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
acyl-protein thioesterase 1
-
exhibits deacylation activity as well as lysophospholipase activity in vitro
acylprotein thioesterase 1
Q6IAQ1
-
AfPlb1
B0Y665
-
AfPlb2
Q9P8P4
-
AfPlb3
B0XZV8
-
APT1
-
APT1 exhibits deacylation activity as well as lysophospholipase activity in vitro
CbPlb1
Q96WX0
-
Charcot-Leyden crystal protein
-
-
-
-
Charcot-Leyden crystal protein homolog
-
-
-
-
CLC
-
-
-
-
CnLYSO1
Q8NKD2
-
cPLA2gamma
-
enzyme also possesses transacylation activity: with addition of lysophosphatidic acid/phosphatidic acid, pH above 8, and elevated temperature markedly increases transacylation activity
endothelial lipase
-
-
eosinophil Charcot-Leyden crystal protein
-
-
eosinophil lysophospholipases
Q05315
-
eosinophil lysophospholipases
-
-
Galactin-10
-
-
-
-
Galectin-10
-
-
-
-
h-LPTA
-
-
hLysoPLA
Q05315
-
hLysoPLA
-
-
hLysoPLA I
-
-
LCAT-like lysophospholipase
-
-
lecithinase B
-
-
-
-
lecitholipase
-
-
-
-
LLPL
-
-
LPLase
Q05315
-
LPLase
-
-
Lysolecithin acylhydrolase
-
-
-
-
lysolecithinase
-
-
-
-
lysophopholipase L2
-
-
-
-
lysophosphatidase
-
-
-
-
lysophosphatidylcholine hydrolase
-
-
-
-
lysophosphatidylcholine lysophospholipase
-
-
lysophosphatidylcholine/transacylase
-
-
lysophospholipase
Q6P4A8
-
lysophospholipase
-
-
lysophospholipase
-
-
lysophospholipase
-
-
lysophospholipase
Q8TZI9
-
lysophospholipase
-
-
lysophospholipase
Q9U8F2
-
lysophospholipase 1
Q6IAQ1
-
lysophospholipase 2
-
-
lysophospholipase 3
-
-
lysophospholipase A
-
-
lysophospholipase A
Q8GNM7
-
lysophospholipase A
Legionella pneumophila JR32
-
-
-
lysophospholipase A1
-
-
-
-
lysophospholipase C
-
-
lysophospholipase I
-
isoform
lysophospholipase I
-
-
lysophospholipase I
-
isoform
lysophospholipase II
-
isoform
lysophospholipase L2
-
-
lysophospholipase-transacylase
-
-
lysoPLA
-
-
lysoPLA
-
-
LysoPLA I
-
-
neuropathy target esterase
B0FLU6
-
NTE
B0FLU6
-
NTE-related esterase
-
-
phosphatidase B
-
-
-
-
phospholipase A
-
-
phospholipase B
-
-
-
-
phospholipase B
-
-
phospholipase B
-
enzymes harbors three distinct activities: a sn-1 and sn-2 fatty acid ester hydrolase, a lysophospholipase and a transacylase activity
phospholipase B
Q96WX0
enzymes harbors three distinct activities: a sn-1 and sn-2 fatty acid ester hydrolase, a lysophospholipase and a transacylase activity
phospholipase B
-
-
phospholipase B
-
enzymes harbors three distinct activities: a sn-1 and sn-2 fatty acid ester hydrolase, a lysophospholipase and a transacylase activity
phospholipase B
Q9P8L1
-
phospholipase B
Q6P4A8
-
phospholipase B
Q939K7
-
phospholipase B
-
enzymes harbors three distinct activities: a sn-1 and sn-2 fatty acid ester hydrolase, a lysophospholipase and a transacylase activity
phospholipase B precursor
Q6P4A8
-
phospholipase B/lipase
-
-
phospholipase B1
-
-
PLB
Q6P4A8
-
PLB
Q939K7
-
PLB/LIP
-
-
PLB1 enzyme
-
-
TAP
-
multifunctional enzyme with thioesterase, esterase, arylesterase, protease and lysophosphilipase activities
TAP
-
multifunctional lysophospholipasethioesterase I/protease I/lysophospholipase L1
thioesterase I/protease I/lysophospholipase L1
-
multifunctional enzyme with thioesterase, esterase, arylesterase, protease and lysophosphilipase activities
thioesterase I/protease I/lysophospholipase L1
-
multifunctional lysophospholipase
lysoPLC
-
enzyme also possesses GPC phoshocholine phosphodiesterase activity and uses glycerophosphorylcholine as a substrate
additional information
-
lysophospholipase activity of lysophosphatidylcholine/transacylase is smaller than the transacylase activity
CAS REGISTRY NUMBER
COMMENTARY
9001-85-8
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
ecotype Col-0
-
-
Manually annotated by BRENDA team
lysophospholipase I and lysophospholipase II
-
-
Manually annotated by BRENDA team
; the genome encodes five phospholipase B genes
-
-
Manually annotated by BRENDA team
precursor; serotype A H99
Q9P8L1
SwissProt
Manually annotated by BRENDA team
var. grubii
GenBank
Manually annotated by BRENDA team
var. grubii H99 wild-type strain and its PLB1 deletion mutant strain (the _plb1 strain)
-
-
Manually annotated by BRENDA team
var. grubii, strain H99
-
-
Manually annotated by BRENDA team
adult Beijing white laying hen
UniProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
var. Advance, at least 3 enzymatic forms: PLP I, PLP II and PLP II'
-
-
Manually annotated by BRENDA team
-
Q8GNM7
SwissProt
Manually annotated by BRENDA team
Legionella pneumophila JR32
-
-
-
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
lysophospholipase I and II
-
-
Manually annotated by BRENDA team
membrane-associated precursor
SwissProt
Manually annotated by BRENDA team
native enzyme and modified enzyme that is generated by the introduction of some nicks into the native type of enzyme
-
-
Manually annotated by BRENDA team
-
Q8TZI9
UniProt
Manually annotated by BRENDA team
2 enzyme forms: phospholipase B1 and phospholipase B2
-
-
Manually annotated by BRENDA team
the genome encodes three phospholipase B genes
-
-
Manually annotated by BRENDA team
; enzyme exhibits the GXSXG consensus active site characteristic of serine proteases, esterases, and lipases, and includes the catalytic triad motif of Ser—Asp—His residues characteristic of serine hydrolases. Three-dimensional structural predictions indicate that the putative catalytic triad formed by these three residues is located at the alpha/beta-hydrolase fold characteristic of the lipases and esterases
UniProt
Manually annotated by BRENDA team
enzyme exhibits the GXSXG consensus active site characteristic of serine proteases, esterases, and lipases, and includes the catalytic triad motif of Ser—Asp—His residues characteristic of serine hydrolases. Three-dimensional structural predictions indicate that the putative catalytic triad formed by these three residues is located at the alpha/beta-hydrolase fold characteristic of the lipases and esterases
UniProt
Manually annotated by BRENDA team
IC50 VALUE [mM]
IC50 VALUE [mM] Maximum
INHIBITOR
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
0.01
-
1,12-bis(tributylammonium)dodecane
-
-
0.0075
-
1,12-bis(trihexylammonium)dodecane
-
-
0.0075
-
1,12-bis(triisopentylammonium)dodecane
-
-
0.0035
-
1,12-bis(tripentylammonium)dodecane
-
-
0.007
-
1,12-bis(tripropylammonium)dodecane
-
-
pI VALUE
pI VALUE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
3.5
-
-
2D-electrophoresis
3.9
-
-
isoelectric focusing
5.1
-
-
isoelectric focusing, 63000 Da species
6.05
-
Q9U8F2, -
determined by isoelectric focusing, SDS-PAGE, extract of adult Schistosoma japonicum worm
6.3
-
-
isoelectric focusing, isoenzyme LPL1
6.3
-
-
isoelectric focusing 52000 Da species
6.4
-
Q8NKD2
predicted from nucleotide sequence
7.06
-
Q9U8F2, -
predicted
Crystallization/COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
crystal structure of the multifunctional thioesterase I/protease I/lysophospholipase L1 in complex with octanoic acid and of the L109P mutant enzyme in complex with octanoic acid
-