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1,2-dilinoleoyl-phosphatidylcholine + H2O
1-linoleoyl-glycerophosphorylcholine + linoleic acid
-
-
-
-
?
1,2-dilinoleoyl-phosphatidylcholine + H2O
1-linoleoyl-sn-glycero-3-phosphocholine + linoleic acid
-
-
-
-
?
1,2-dioleoyl-sn-phosphatidylethanolamine + H2O
1-oleoyl-sn-phosphatidylethanolamine + oleic acid
-
-
-
?
1,2-dipalmitoyl-phosphatidylcholine + H2O
1-palmitoyl-glycerophosphorylcholine + palmitic acid
1,2-dipalmitoyl-sn-glycero-3-phosphorylcholine + H2O
1-palmitoyl-sn-glycero-3-phosphorylcholine + palmitate
-
-
-
-
?
1,2-dipalmitoyl-sn-phosphatidylcholine + H2O
1-palmitoyl-sn-phosphatidylcholine + palmitate
the catalytic site for aiPLA2 activity is an S32-H26-D140 triad
-
-
?
1,2-dipalmitoyl-sn-phosphatidylserine + H2O
1-palmitoyl-sn-phosphatidylserine + palmitic acid
-
-
-
?
1-acyl-2-arachidonoyl-sn-glycero-3-phosphoethanolamine + H2O
1-acyl-sn-glycero-3-phosphoethanolamine + arachidonic acid
1-acyl-2-arachidonoyl-sn-glycerophosphoethanolamine + H2O
1-acyl-sn-glycerophosphoethanolamine + arachidonic acid
-
-
-
?
1-palmitoyl-2-arachidonoylphosphatidylcholine + H2O
1-palmitoyl-glycerophosphorylcholine + arachidonic acid
1-palmitoyl-2-arachidonyl-phosphatidylcholine + H2O
1-palmitoyl-sn-glycero-3-phosphocholine + arachidonic acid
-
-
-
-
?
1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphocholine + H2O
1-palmitoyl-sn-glycero-3-phosphorylcholine + arachidonic acid
-
-
-
-
?
1-palmitoyl-2-linoleoyl-phosphatidic acid + H2O
1-palmitoyl-sn-glycero-3-phosphate + linoleic acid
-
-
-
-
?
1-palmitoyl-2-linoleoyl-phosphatidylcholine + H2O
1-palmitoyl-sn-glycero-3-phosphocholine + linoleic acid
-
-
-
-
?
1-palmitoyl-2-linoleoyl-phosphatidylethanolamine + H2O
1-palmitoyl-sn-glycerophosphoethanolamine + linoleic acid
-
-
-
-
?
1-palmitoyl-2-linoleoyl-phosphatidylinositol + H2O
1-palmitoyl-3-phosphoinositol + linoleic acid
-
-
-
-
?
1-palmitoyl-2-linoleoyl-phosphatidylserine + H2O
1-palmitoyl-sn-glycero-3-phosphoserine + linoleic acid
-
-
-
-
?
1-palmitoyl-2-linoleoylphosphatidylcholine + H2O
1-palmitoyl-glycerophosphorylcholine + linolic acid
1-palmitoyl-2-linoleoylphosphatidylethanolamine + H2O
1-palmitoyl-glycerophosphorylethanolamine + linolic acid
1-palmitoyl-2-oleoylphosphatidylcholine + H2O
1-palmitoyl-glycerophosphocholine + oleic acid
-
data for iPLA2
-
?
1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphoinositol + H2O
1-stearoyl-sn-glycero-3-phosphoinositol + arachidonic acid
-
-
-
?
1-stearoyl-2-arachidonoylphosphatidylcholine + H2O
1-stearoyl-glycerophosphorylcholine + arachidonic acid
arachidonyl phosphatidylethanolamine + H2O
glycerophosphoethanolamine + arachidonic acid
-
-
-
-
?
diphosphatidylglycerol + H2O
?
-
-
-
-
?
hen egg phosphatidylcholine + H2O
?
-
-
-
-
?
L-1-acyl-2-arachidonyl-sn-glycerol-3-phosphatidylethanolamine + H2O
?
-
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + fatty acid
phosphatidylethanolamine + H2O
1-acylglycerophosphorylethanolamine + fatty acid
phosphatidylglycerol + H2O
1-acylglycerol + fatty acid
additional information
?
-
1,2-dipalmitoyl-phosphatidylcholine + H2O
1-palmitoyl-glycerophosphorylcholine + palmitic acid
-
-
-
?
1,2-dipalmitoyl-phosphatidylcholine + H2O
1-palmitoyl-glycerophosphorylcholine + palmitic acid
-
-
-
?
1,2-dipalmitoyl-phosphatidylcholine + H2O
1-palmitoyl-glycerophosphorylcholine + palmitic acid
-
data for iPLA2
-
?
1-acyl-2-arachidonoyl-sn-glycero-3-phosphoethanolamine + H2O
1-acyl-sn-glycero-3-phosphoethanolamine + arachidonic acid
-
-
-
?
1-acyl-2-arachidonoyl-sn-glycero-3-phosphoethanolamine + H2O
1-acyl-sn-glycero-3-phosphoethanolamine + arachidonic acid
-
-
-
?
1-palmitoyl-2-arachidonoylphosphatidylcholine + H2O
1-palmitoyl-glycerophosphorylcholine + arachidonic acid
-
-
-
?
1-palmitoyl-2-arachidonoylphosphatidylcholine + H2O
1-palmitoyl-glycerophosphorylcholine + arachidonic acid
-
,data for iPLA2
-
?
1-palmitoyl-2-linoleoylphosphatidylcholine + H2O
1-palmitoyl-glycerophosphorylcholine + linolic acid
-
-
-
?
1-palmitoyl-2-linoleoylphosphatidylcholine + H2O
1-palmitoyl-glycerophosphorylcholine + linolic acid
-
iPLA2
-
?
1-palmitoyl-2-linoleoylphosphatidylethanolamine + H2O
1-palmitoyl-glycerophosphorylethanolamine + linolic acid
-
-
-
?
1-palmitoyl-2-linoleoylphosphatidylethanolamine + H2O
1-palmitoyl-glycerophosphorylethanolamine + linolic acid
-
-
-
?
1-palmitoyl-2-linoleoylphosphatidylethanolamine + H2O
1-palmitoyl-glycerophosphorylethanolamine + linolic acid
-
-
-
-
?
1-palmitoyl-2-linoleoylphosphatidylethanolamine + H2O
1-palmitoyl-glycerophosphorylethanolamine + linolic acid
-
data for iPLA2
-
?
1-stearoyl-2-arachidonoylphosphatidylcholine + H2O
1-stearoyl-glycerophosphorylcholine + arachidonic acid
-
-
-
?
1-stearoyl-2-arachidonoylphosphatidylcholine + H2O
1-stearoyl-glycerophosphorylcholine + arachidonic acid
-
data for iPLA2
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + fatty acid
-
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + fatty acid
-
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + fatty acid
-
-
-
?
phosphatidylethanolamine + H2O
1-acylglycerophosphorylethanolamine + fatty acid
-
-
-
?
phosphatidylethanolamine + H2O
1-acylglycerophosphorylethanolamine + fatty acid
-
-
-
?
phosphatidylethanolamine + H2O
1-acylglycerophosphorylethanolamine + fatty acid
-
-
-
?
phosphatidylethanolamine + H2O
1-acylglycerophosphorylethanolamine + fatty acid
-
-
-
?
phosphatidylglycerol + H2O
1-acylglycerol + fatty acid
-
-
-
?
phosphatidylglycerol + H2O
1-acylglycerol + fatty acid
-
-
-
?
phospholipids + H2O
?
-
-
-
-
?
phospholipids + H2O
?
-
influence on platelet aggregation
-
-
?
phospholipids + H2O
?
-
eicosanoids
-
-
?
phospholipids + H2O
?
-
inflammatory diseases
-
-
?
phospholipids + H2O
?
-
release of arachidonic acid: biosynthesis of leucotrienes, thromboxans and prostaglandins
-
-
?
additional information
?
-
-
increased phospholipase A2 activity and inflammatory response but decreased nerve growth factor expression in the olfactory bulbectomized rat model of depression, the effects are associated with increased interleukin-1beta and prostaglandin E2 in the serum and brain, overview
-
-
?
additional information
?
-
-
peroxiredoxin 6 is a bifunctional protein with both GSH peroxidase and phospholipase A2 activities, and is responsible for the metabolism of lung surfactant phospholipids. Prdx6 has a major role in degradation of internalized dipalmitoyl phosphatidylcholine as well as in the remodeling of PC through the deacylation-reacylation pathway by lung granular pneumocytes, i.e. alveolar epithelial type II cells. Mitrogen-activated protein kinase-mediated phosphorylation of peroxiredoxin 6 regulates its phospholipase A2 activity, overview
-
-
?
additional information
?
-
-
phospholipases A2 catalyze hydrolysis of fatty acids from the sn-2 position of phospholipids
-
-
?
additional information
?
-
-
the phospholipase A2 superfamily consists of many different groups of enzymes that catalyze the hydrolysis of the sn-2 ester bond in a variety of different phospholipids, products of the hydrolysis of the sn-2 ester bond of phospholipid are a free fatty acid and lysophospholipid
-
-
?
additional information
?
-
-
AdPLA is most likely a His-Cys PLA2, His23 and Cys113 are critical for activity of AdPLA, catalytic mechanism, overview. AdPLA has phospholipase activity but lacks acyltransferase activity
-
-
?
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(6E)-6-(bromomethylene)-3-(1-naphthyl)tetrahydro-2H-pyran-2-one
-
i.e. BEL, bromoenol lactone suicide inhibitor, alkylates Cys-residues
1-hexadecyl-3-trifluoroethylglycero-sn-2-phosphomethanol
-
MJ33, competitive inhibitor
3-[2-[2-(2,2-diphenylethyl)-3,5-dioxo-1,2,4-oxadiazolidin-4-yl]ethoxy]benzoate
-
-
4-(((2E)-4-[1-(diphenylmethyl)-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl]but-2-en-1-yl)oxy)benzoic acid
-
-
4-(((2E)-4-[3-(diphenylmethyl)-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl]but-2-en-1-yl)oxy)benzoic acid
-
-
4-(((2E)-4-[3-(diphenylmethyl)-2,4-dioxo-7-(1H-1,2,4-triazol-1-yl)-3,4-dihydroquinazolin-1(2H)-yl]but-2-en-1-yl)oxy)benzoic acid
-
-
4-(((2E)-4-[3-(diphenylmethyl)-7-fluoro-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl]but-2-en-1-yl)oxy)benzoic acid
-
-
4-(((2E)-4-[3-(diphenylmethyl)-7-methoxy-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl]but-2-en-1-yl)oxy)benzoic acid
-
-
4-(((2E)-4-[3-(diphenylmethyl)-7-nitro-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl]but-2-en-1-yl)oxy)benzoic acid
-
-
4-(((2E)-4-[7-chloro-3-(diphenylmethyl)-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl]but-2-en-1-yl)oxy)benzoic acid
-
-
4-([(2E)-4-[2-(2,2-diphenylethyl)-3,5-dioxo-1,2,4-oxadiazolidin-4-yl]but-2-en-1-yl]oxy)benzoate
-
-
4-([(2E)-4-[3-(diphenylmethyl)-2,4,6-trioxo-5-prop-2-en-1-yl-1,3,5-triazinan-1-yl]but-2-en-1-yl]oxy)benzoic acid
-
-
4-([(2E)-4-[3-(diphenylmethyl)-5-ethyl-2,4,6-trioxo-1,3,5-triazinan-1-yl]but-2-en-1-yl]oxy)benzoic acid
-
-
4-([(2E)-4-[3-benzyl-5-(diphenylmethyl)-2,4,6-trioxo-1,3,5-triazinan-1-yl]but-2-en-1-yl]oxy)benzoic acid
-
-
4-([(2E)-4-[3-butyl-5-(diphenylmethyl)-2,4,6-trioxo-1,3,5-triazinan-1-yl]but-2-en-1-yl]oxy)benzoic acid
-
-
4-([4-[2-(2,2-diphenylethyl)-3,5-dioxo-1,2,4-oxadiazolidin-4-yl]but-2-yn-1-yl]oxy)benzoate
-
-
4-[2-[2-(1-benzyl-2-phenylethyl)-3,5-dioxo-1,2,4-oxadiazolidin-4-yl]ethoxy]benzoate
-
-
4-[2-[2-(2,2-diphenylethyl)-3,5-dioxo-1,2,4-oxadiazolidin-4-yl]ethoxy]-2-hydroxybenzoate
-
-
4-[2-[2-(2,2-diphenylethyl)-3,5-dioxo-1,2,4-oxadiazolidin-4-yl]ethoxy]benzoate
-
-
4-[2-[2-(diphenylmethyl)-3,5-dioxo-1,2,4-oxadiazolidin-4-yl]ethoxy]benzoate
-
-
4-[2-[3-(2,2-diphenylethyl)-5-ethyl-2,4,6-trioxo-1,3,5-triazinan-1-yl]ethoxy]benzoic acid
-
-
4-[2-[3-(diphenylmethyl)-2,4,6-trioxo-5-phenyl-1,3,5-triazinan-1-yl]ethoxy]benzoic acid
-
-
4-[2-[3-(diphenylmethyl)-2,4,6-trioxo-5-prop-2-en-1-yl-1,3,5-triazinan-1-yl]ethoxy]benzoic acid
-
-
4-[2-[3-(diphenylmethyl)-5-ethyl-2,4,6-trioxo-1,3,5-triazinan-1-yl]ethoxy]benzoic acid
-
-
4-[2-[3-benzyl-5-(diphenylmethyl)-2,4,6-trioxo-1,3,5-triazinan-1-yl]ethoxy]benzoic acid
-
-
4-[2-[3-butyl-5-(diphenylmethyl)-2,4,6-trioxo-1,3,5-triazinan-1-yl]ethoxy]benzoic acid
-
-
4-[2-[5-chloro-1-(diphenylmethyl)-2-methyl-1H-indol-3-yl]ethoxy]benzoic acid
-
-
4-[3-[2-(2,2-diphenylethyl)-3,5-dioxo-1,2,4-oxadiazolidin-4-yl]propoxy]benzoate
-
-
4-[4-[2-(2,2-diphenylethyl)-3,5-dioxo-1,2,4-oxadiazolidin-4-yl]butoxy]benzoate
-
-
7,7-dimethyl-5,8-eicosadienoic acid
-
-
acteoside
-
phenylethanoid glycoside isolated from Clerodendron trichotomum Thunberg, competitive. Acts on cytosolic Ca2+-dependent phospholipase A2 rather than secretory phospholipase A2
anti-peptide antibody
-
group II PLA2-antibody
-
arachidonyl trifluoromethyl ketone
deoxycholate
-
substrate: phosphatidylcholine
diethyl 4-nitrophenyl phosphate
-
hexadecyl-3-trifluorethylglycero-sn-2-phospho-methanol
-
i.e. MJ33
lysophosphatidylcholines
-
inhibitory plasma compounds, profile determination by mass spectroscopy, overview
methyl arachidonyl fluorophosphate
-
i.e. MAFP, an inhibitor of cysteine-dependent phospholipases
methyl-arachidonylfluorophosphonate
-
irreversible inhibitor of cPLA2 and iPLA2. Ser214 site in microtubule-associated protein Tau is hyperphosphorylated upon inhibitor treatment
palmitoyl lysophosphatidylcholines
-
competitive product inhibition
-
pure phospholipid vesicles
-
exception: vesicles composed of phosphatidylcholine or phosphatidylinositol 4,5-bisphosphate
-
stearoyl lysophosphatidylcholines
-
competitive product inhibition
-
surfactant protein A
-
-
-
arachidonyl trifluoromethyl ketone
-
-
arachidonyl trifluoromethyl ketone
-
i.e. AACOCF3
arachidonyl trifluoromethyl ketone
-
i.e. AACOCF3, a cPLA2-specific inhibitor
Ca2+
-
30% decrease of activity at 5-10 mM
Ca2+
-
partial inhibition, isoform PLA2-H
additional information
-
inhibition mechanisms of 1,2,4-oxadiazolidin-3,5-diones and 1,3,5-triazin-2,4,6-triones, overview
-
additional information
-
SB202190 and PD98059 abolish the enzyme activation by phosphorylation through protein kinase C by specific inhibition of PKC
-
additional information
-
no inhibition of AdPLA and sPLA2 by bromoenolactone
-
additional information
-
no inhibition by decanoyl lysophosphatidylcholine in vitro
-
additional information
no inhibition by bromoenol lactone
-
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0.05
3-[2-[2-(2,2-diphenylethyl)-3,5-dioxo-1,2,4-oxadiazolidin-4-yl]ethoxy]benzoate
Rattus norvegicus
-
above
0.012
4-(((2E)-4-[1-(diphenylmethyl)-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl]but-2-en-1-yl)oxy)benzoic acid
Rattus norvegicus
-
whole blood assay
0.014
4-(((2E)-4-[3-(diphenylmethyl)-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl]but-2-en-1-yl)oxy)benzoic acid
Rattus norvegicus
-
whole blood assay
0.011
4-(((2E)-4-[3-(diphenylmethyl)-2,4-dioxo-7-(1H-1,2,4-triazol-1-yl)-3,4-dihydroquinazolin-1(2H)-yl]but-2-en-1-yl)oxy)benzoic acid
Rattus norvegicus
-
whole blood assay
0.006
4-(((2E)-4-[3-(diphenylmethyl)-7-fluoro-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl]but-2-en-1-yl)oxy)benzoic acid
Rattus norvegicus
-
whole blood assay
0.009
4-(((2E)-4-[3-(diphenylmethyl)-7-methoxy-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl]but-2-en-1-yl)oxy)benzoic acid
Rattus norvegicus
-
whole blood assay
0.013
4-(((2E)-4-[3-(diphenylmethyl)-7-nitro-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl]but-2-en-1-yl)oxy)benzoic acid
Rattus norvegicus
-
whole blood assay
0.011
4-(((2E)-4-[7-chloro-3-(diphenylmethyl)-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl]but-2-en-1-yl)oxy)benzoic acid
Rattus norvegicus
-
whole blood assay
0.05
4-([(2E)-4-[2-(2,2-diphenylethyl)-3,5-dioxo-1,2,4-oxadiazolidin-4-yl]but-2-en-1-yl]oxy)benzoate
Rattus norvegicus
-
above
0.0013
4-([(2E)-4-[3-(diphenylmethyl)-2,4,6-trioxo-5-prop-2-en-1-yl-1,3,5-triazinan-1-yl]but-2-en-1-yl]oxy)benzoic acid
Rattus norvegicus
-
-
0.0016
4-([(2E)-4-[3-(diphenylmethyl)-5-ethyl-2,4,6-trioxo-1,3,5-triazinan-1-yl]but-2-en-1-yl]oxy)benzoic acid
Rattus norvegicus
-
-
0.0013
4-([(2E)-4-[3-benzyl-5-(diphenylmethyl)-2,4,6-trioxo-1,3,5-triazinan-1-yl]but-2-en-1-yl]oxy)benzoic acid
Rattus norvegicus
-
-
0.0024
4-([(2E)-4-[3-butyl-5-(diphenylmethyl)-2,4,6-trioxo-1,3,5-triazinan-1-yl]but-2-en-1-yl]oxy)benzoic acid
Rattus norvegicus
-
-
0.023
4-([4-[2-(2,2-diphenylethyl)-3,5-dioxo-1,2,4-oxadiazolidin-4-yl]but-2-yn-1-yl]oxy)benzoate
Rattus norvegicus
-
-
0.05
4-[2-[2-(1-benzyl-2-phenylethyl)-3,5-dioxo-1,2,4-oxadiazolidin-4-yl]ethoxy]benzoate
Rattus norvegicus
-
above
0.027
4-[2-[2-(2,2-diphenylethyl)-3,5-dioxo-1,2,4-oxadiazolidin-4-yl]ethoxy]-2-hydroxybenzoate
Rattus norvegicus
-
-
0.0067
4-[2-[2-(2,2-diphenylethyl)-3,5-dioxo-1,2,4-oxadiazolidin-4-yl]ethoxy]benzoate
Rattus norvegicus
-
-
0.05
4-[2-[2-(diphenylmethyl)-3,5-dioxo-1,2,4-oxadiazolidin-4-yl]ethoxy]benzoate
Rattus norvegicus
-
above
0.03
4-[2-[3-(2,2-diphenylethyl)-5-ethyl-2,4,6-trioxo-1,3,5-triazinan-1-yl]ethoxy]benzoic acid
Rattus norvegicus
-
-
0.05
4-[2-[3-(diphenylmethyl)-2,4,6-trioxo-5-phenyl-1,3,5-triazinan-1-yl]ethoxy]benzoic acid
Rattus norvegicus
-
above
0.005
4-[2-[3-(diphenylmethyl)-2,4,6-trioxo-5-prop-2-en-1-yl-1,3,5-triazinan-1-yl]ethoxy]benzoic acid
Rattus norvegicus
-
-
0.0075
4-[2-[3-(diphenylmethyl)-5-ethyl-2,4,6-trioxo-1,3,5-triazinan-1-yl]ethoxy]benzoic acid
Rattus norvegicus
-
-
0.0035
4-[2-[3-benzyl-5-(diphenylmethyl)-2,4,6-trioxo-1,3,5-triazinan-1-yl]ethoxy]benzoic acid
Rattus norvegicus
-
-
0.0056
4-[2-[3-butyl-5-(diphenylmethyl)-2,4,6-trioxo-1,3,5-triazinan-1-yl]ethoxy]benzoic acid
Rattus norvegicus
-
-
0.003
4-[2-[5-chloro-1-(diphenylmethyl)-2-methyl-1H-indol-3-yl]ethoxy]benzoic acid
Rattus norvegicus
-
-
0.0124
4-[3-[2-(2,2-diphenylethyl)-3,5-dioxo-1,2,4-oxadiazolidin-4-yl]propoxy]benzoate
Rattus norvegicus
-
-
0.05
4-[4-[2-(2,2-diphenylethyl)-3,5-dioxo-1,2,4-oxadiazolidin-4-yl]butoxy]benzoate
Rattus norvegicus
-
above
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PA24A_RAT
752
0
85707
Swiss-Prot
other Location (Reliability: 2)
PRDX6_RAT
224
0
24819
Swiss-Prot
other Location (Reliability: 1)
PA2G5_RAT
137
0
15996
Swiss-Prot
Secretory Pathway (Reliability: 1)
PA2GA_RAT
146
1
16294
Swiss-Prot
Secretory Pathway (Reliability: 1)
PA2GC_RAT
150
1
16919
Swiss-Prot
Secretory Pathway (Reliability: 2)
PA21B_RAT
146
0
16424
Swiss-Prot
Secretory Pathway (Reliability: 2)
PA2GX_RAT
151
0
17088
Swiss-Prot
Secretory Pathway (Reliability: 2)
PLAT3_RAT
160
1
17749
Swiss-Prot
other Location (Reliability: 2)
PLAT5_RAT
287
0
31749
Swiss-Prot
Mitochondrion (Reliability: 3)
PLPL2_RAT
478
0
52567
Swiss-Prot
Secretory Pathway (Reliability: 5)
PLAT1_RAT
167
0
18521
Swiss-Prot
other Location (Reliability: 2)
PLB1_RAT
1450
1
161089
Swiss-Prot
Secretory Pathway (Reliability: 1)
PAG15_RAT
413
1
47391
Swiss-Prot
Secretory Pathway (Reliability: 3)
PLPL9_RAT
807
0
89556
Swiss-Prot
Mitochondrion (Reliability: 4)
A0A8I6GKG0_RAT
1396
1
155749
TrEMBL
other Location (Reliability: 4)
A0A8I6AW05_RAT
145
0
16517
TrEMBL
Mitochondrion (Reliability: 2)
Q6IRF5_RAT
752
0
85649
TrEMBL
other Location (Reliability: 2)
F1M7W5_RAT
1111
0
122945
TrEMBL
Secretory Pathway (Reliability: 1)
F7F420_RAT
152
1
17141
TrEMBL
Secretory Pathway (Reliability: 3)
D3Z9B7_RAT
860
0
97689
TrEMBL
Secretory Pathway (Reliability: 3)
D3ZLB5_RAT
210
1
23450
TrEMBL
other Location (Reliability: 3)
A0A8I6ANS2_RAT
828
0
95516
TrEMBL
other Location (Reliability: 2)
A0A8I6AFX4_RAT
776
0
88256
TrEMBL
Mitochondrion (Reliability: 1)
B6VNU2_RAT
46
0
5331
TrEMBL
other Location (Reliability: 2)
A0A8I6G4E1_RAT
143
0
16112
TrEMBL
Secretory Pathway (Reliability: 2)
D3ZQH6_RAT
825
0
92923
TrEMBL
other Location (Reliability: 4)
B6VNU1_RAT
46
0
5347
TrEMBL
other Location (Reliability: 2)
A0A8I6ASV9_RAT
152
0
17048
TrEMBL
Mitochondrion (Reliability: 4)
A0A8I6A4T3_RAT
142
0
16336
TrEMBL
Secretory Pathway (Reliability: 4)
A0A8I6AKA4_RAT
851
0
98098
TrEMBL
other Location (Reliability: 5)
Q6DQ95_RAT
151
0
16925
TrEMBL
Secretory Pathway (Reliability: 2)
F1LPY6_RAT
874
0
100169
TrEMBL
other Location (Reliability: 2)
A0A8I6ALE8_RAT
140
0
15969
TrEMBL
Mitochondrion (Reliability: 4)
Q5BK35_RAT
144
0
16268
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8I5ZNU3_RAT
744
0
84695
TrEMBL
other Location (Reliability: 2)
A0A8I6A5J8_RAT
133
0
15511
TrEMBL
other Location (Reliability: 3)
Q4V8L7_RAT
158
1
17722
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0G2KAA9_RAT
750
0
85436
TrEMBL
other Location (Reliability: 2)
F7EZZ6_RAT
785
0
89171
TrEMBL
Mitochondrion (Reliability: 5)
G3V6E2_RAT
151
0
17040
TrEMBL
Secretory Pathway (Reliability: 2)
D4A1I6_RAT
791
0
89555
TrEMBL
other Location (Reliability: 3)
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Regional distribution, ontogeny, purification, and characterization of the Ca2+-independent phospholipase A2 from rat brain
J. Neurochem.
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1278-1287
1999
Rattus norvegicus
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Larsson Forsell, P.K.A.; Kennedy, B.P.; Claesson, H.E.
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Eur. J. Biochem.
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1999
Rattus norvegicus, Homo sapiens (O60733), Homo sapiens
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Biochim. Biophys. Acta
1394
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1998
Homo sapiens, Mus musculus, Rattus norvegicus
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Oishi, T.; Tamiya-Koizumi, K.; Kudo, I.; Iino, S.; Takagi, K.; Yoshida, Y.
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1996
Rattus norvegicus
brenda
Wang, R.; Dodia, C.R.; Jain, M.K.; Fisher, A.B.
Purification and characterization of a calcium-independent acidic phospholipase A2 from rat lung
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1994
Rattus norvegicus
brenda
Nakatani, Y.; Hara, S.; Murakami, M.; Kudo, I.; Inoue, K.
Characterization of cytosolic phospholipase A2 in rat mastocystoma RBL-2H3
Biol. Pharm. Bull.
17
47-50
1994
Rattus norvegicus
brenda
Vignais, P.M.; Colbeau, A.; Ngo-Tri, H.; Pilarska, M.
Characterization and subcellular localization of lipase and phospholipase A activities in rat liver
Lipids
1
117-126
1976
Rattus norvegicus
-
brenda
Rahman, Y.E.; Cerny, E.A.; Peraino, C.
Purification and some properties of rat spleen phospholipase A
Biochim. Biophys. Acta
321
526-535
1973
Rattus norvegicus, Sus scrofa
brenda
Hanahan, D.J.
Phospholipases
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
5
71-85
1971
Crotalus adamanteus, Crotalus atrox, Rattus norvegicus, Sus scrofa
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brenda
Winstead, M.V.; Balsinde, J.; Dennis, E.A.
Calcium-independent phospholipase A2: structure and function
Biochim. Biophys. Acta
1488
28-39
2000
Homo sapiens, Mammalia, Mus musculus, Rattus norvegicus
brenda
Lee, D.; Won, J.H.; Auh, C.K.; Park, Y.M.
Purification and characterization of a cytosolic phospholipase A2 from rat liver
Mol. Cells
16
361-367
2003
Rattus norvegicus
brenda
Farooqui, A.A.; Ong, W.Y.; Horrocks, L.A.; Farooqui, T.
Brain cytosolic phospholipase A2: localization, role, and involvement in neurological diseases
Neuroscientist
6
169-180
2000
Bos taurus, Homo sapiens, Mammalia, Rattus norvegicus
-
brenda
Song, H.; Ramanadham, S.; Bao, S.; Hsu, F.F.; Turk, J.
A bromoenol lactone suicide substrate inactivates group VIA phospholipase A2 by generating a diffusible bromomethyl keto acid that alkylates cysteine thiols
Biochemistry
45
1061-1073
2006
Rattus norvegicus
brenda
Kolko, M.; Christoffersen, N.R.; Barreiro, S.G.; Miller, M.L.; Pizza, A.J.; Bazan, N.G.
Characterization and location of secretory phospholipase A2 groups IIE, V, and X in the rat brain
J. Neurosci. Res.
83
874-882
2006
Rattus norvegicus
brenda
Gopalsamy, A.; Yang, H.; Ellingboe, J.W.; McKew, J.C.; Tam, S.; Joseph-McCarthy, D.; Zhang, W.; Shen, M.; Clark, J.D.
1,2,4-Oxadiazolidin-3,5-diones and 1,3,5-triazin-2,4,6-triones as cytosolic phospholipase A2alpha inhibitors
Bioorg. Med. Chem. Lett.
16
2978-2981
2006
Rattus norvegicus
brenda
Wu, Y.; Feinstein, S.I.; Manevich, Y.; Chowdhury, I.; Pak, J.H.; Kazi, A.; Dodia, C.; Speicher, D.W.; Fisher, A.B.
Mitrogen-activated protein kinase-mediated phosphorylation of peroxiredoxin 6 regulates its phospholipase A2 activity
Biochem. J.
419
669-679
2009
Homo sapiens, Rattus norvegicus
brenda
Burke, J.E.; Dennis, E.A.
Phospholipase A2 biochemistry
Cardiovasc. Drugs Ther.
23
49-59
2009
Apis mellifera, Bitis gabonica, Bos taurus, Crotalus sp., Homo sapiens, Mus musculus, Naja naja, Oryza sativa, Rattus norvegicus, Sus scrofa, Protoparvovirus
brenda
Duncan, R.E.; Sarkadi-Nagy, E.; Jaworski, K.; Ahmadian, M.; Sul, H.S.
Identification and functional characterization of adipose-specific phospholipase A2 (AdPLA)
J. Biol. Chem.
283
25428-25436
2008
Rattus norvegicus
brenda
Cunningham, T.J.; Yao, L.; Lucena, A.
Product inhibition of secreted phospholipase A2 may explain lysophosphatidylcholines unexpected therapeutic properties
J. Inflamm.
5
17
2008
Rattus norvegicus
brenda
Song, C.; Zhang, X.Y.; Manku, M.
Increased phospholipase A2 activity and inflammatory response but decreased nerve growth factor expression in the olfactory bulbectomized rat model of depression: effects of chronic ethyl-eicosapentaenoate treatment
J. Neurosci.
29
14-22
2009
Rattus norvegicus
brenda
Kirincich, S.J.; Xiang, J.; Green, N.; Tam, S.; Yang, H.Y.; Shim, J.; Shen, M.W.; Clark, J.D.; McKew, J.C.
Benzhydrylquinazolinediones: novel cytosolic phospholipase A2alpha inhibitors with improved physicochemical properties
Bioorg. Med. Chem.
17
4383-4405
2009
Rattus norvegicus, synthetic construct
brenda
De-Paula, V.J.; Schaeffer, E.L.; Talib, L.L.; Gattaz, W.F.; Forlenza, O.V.
Inhibition of phospholipase A2 increases Tau phosphorylation at Ser214 in embryonic rat hippocampal neurons
Prostaglandins Leukot. Essent. Fatty Acids
82
57-60
2010
Rattus norvegicus
brenda
Du, Y.R.; Xiao, Y.; Lu, Z.M.; Ding, J.; Xie, F.; Fu, H.; Wang, Y.; Strong, J.A.; Zhang, J.M.; Chen, J.
Melittin activates TRPV1 receptors in primary nociceptive sensory neurons via the phospholipase A2 cascade pathways
Biochem. Biophys. Res. Commun.
408
32-37
2011
Rattus norvegicus
brenda
Song, H.S.; Choi, M.Y.; Ko, M.S.; Jeong, J.M.; Kim, Y.H.; Jang, B.H.; Sung, J.H.; Kim, M.G.; Whang, W.K.; Sim, S.S.
Competitive inhibition of cytosolic Ca2+-dependent phospholipase A2 by acteoside in RBL-2H3 cells
Arch. Pharm. Res.
35
905-910
2012
Rattus norvegicus
brenda
Fisher, A.B.
The phospholipase A2 activity of peroxiredoxin 6
J. Lipid Res.
59
1132-1147
2018
Trematomus bernacchii, Xenopus tropicalis (B1WAZ6), Mus musculus (O08709), Rattus norvegicus (O35244), Bos taurus (O77834), Homo sapiens (P30041), Gallus gallus (Q5ZJF4), Arabidopsis thaliana (Q8S8N6)
brenda