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Information on EC 3.1.1.4 - phospholipase A2 and Organism(s) Danio rerio

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EC Tree
     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.1 Carboxylic-ester hydrolases
                3.1.1.4 phospholipase A2
IUBMB Comments
Also acts on phosphatidylethanolamine, choline plasmalogen and phosphatides, removing the fatty acid attached to the 2-position. Requires Ca2+.
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This record set is specific for:
Danio rerio
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Word Map
The taxonomic range for the selected organisms is: Danio rerio
The enzyme appears in selected viruses and cellular organisms
Synonyms
phospholipase a2, cpla2, spla2, spla(2), prdx6, cytosolic phospholipase a2, crotoxin, pla2s, ipla2, spla2-iia, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
14 kDa phospholipase A2
-
-
-
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Agkistrotoxin
-
-
-
-
amdI1
-
-
-
-
Ammodytin I2
-
-
-
-
APLA
-
-
-
-
APP-D-49
-
-
-
-
ASPLA1
-
-
-
-
ASPLA10
-
-
-
-
ASPLA11
-
-
-
-
ASPLA12
-
-
-
-
ASPLA13
-
-
-
-
ASPLA14
-
-
-
-
ASPLA15
-
-
-
-
ASPLA16
-
-
-
-
ASPLA17
-
-
-
-
ASPLA2
-
-
-
-
ASPLA3
-
-
-
-
ASPLA4
-
-
-
-
ASPLA5
-
-
-
-
ASPLA6
-
-
-
-
ASPLA7
-
-
-
-
ASPLA8
-
-
-
-
ASPLA9
-
-
-
-
ATX
-
-
-
-
Basic protein I/II
-
-
-
-
BJ-PLA2
-
-
-
-
BJUPLA2
-
-
-
-
BPI/BPII
-
-
-
-
CaI-PLA2
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-
-
-
Caudoxin
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-
-
-
cPLA2alpha
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cPm09
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-
-
-
Enhancing factor
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-
-
-
GIIC sPLA2
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-
-
-
GIID sPLA2
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-
-
-
GIIE sPLA2
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-
-
-
GIIF sPLA2
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-
-
-
GIII sPLA2
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-
-
-
Group IB phospholipase A2
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-
-
-
Group IIA phospholipase A2
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-
-
-
Group V phospholipase A2
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-
-
-
Group VI phospholipase A2
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-
-
-
GVI PLA2
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-
-
-
GX sPLA2
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-
-
-
GXII sPLA2
-
-
-
-
GXIII sPLA2
-
-
-
-
iPLA2
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-
-
-
lecithinase A
-
-
-
-
MP-III 4R
-
-
-
-
Muscarinic inhibitor
-
-
-
-
Myotoxin
-
-
-
-
NAJPLA-2A
-
-
-
-
NAJPLA-2B
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-
-
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NAJPLA-2C
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-
-
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Nigexine
-
-
-
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Non-pancreatic secretory phospholipase A2
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-
-
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Notechis 11'2
-
-
-
-
Notexin
-
-
-
-
NPLA
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-
-
-
NPS-PLA2
-
-
-
-
OHV A-PLA2
-
-
-
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OHV-APLA2
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-
-
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pgPLA 1a/pgPLA 2a
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-
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phosphatidase
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-
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phosphatide 2-acylhydrolase
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-
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phosphatidolipase
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-
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Phosphatidylcholine 2-acylhydrolase
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-
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Phosphatidylcholine 2-acylhydrolase GIIC
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Phosphatidylcholine 2-acylhydrolase GIID
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Phosphatidylcholine 2-acylhydrolase GIIE
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Phosphatidylcholine 2-acylhydrolase GIIF
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-
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Phosphatidylcholine 2-acylhydrolase GIII
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-
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Phosphatidylcholine 2-acylhydrolase GX
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Phosphatidylcholine 2-acylhydrolase GXII
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Phosphatidylcholine 2-acylhydrolase GXIII
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phospholipase A
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Phospholipase A2 inhibitor
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phospholipase A2alpha
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pkP5
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-
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PLA2-10
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-
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PLA2-VI
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PLA2-VII
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-
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PLA2IID
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-
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platelet activating factor acetyl hydrolase
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Pt-PLA1
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-
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Pt-PLA2
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-
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Secretory-type PLA, stroma-associated homolog
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-
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sPLA(2)-IID
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-
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sPLA(2)-IIE
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-
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sPLA(2)-IIF
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-
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TMV-K49
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-
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Toxin VI
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Toxin VI:5
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of carboxylic ester
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
phosphatidylcholine 2-acylhydrolase
Also acts on phosphatidylethanolamine, choline plasmalogen and phosphatides, removing the fatty acid attached to the 2-position. Requires Ca2+.
CAS REGISTRY NUMBER
COMMENTARY hide
9001-84-7
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
embryo, developing brain. The enzyme is moderately expressed in a cell cluster restricted to the forebrain and hindbrain with a clearer and more intense signal in the otic vesicles
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
loss of cpla2a expression or inhibition of cpla2a activity diminishes G1 progression through the cell cycle
metabolism
through its phospholipase activity, the enzyme is a critical effector ofG1 phase progression through the cell cycle
physiological function
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
PA24A_DANRE
741
0
83809
Swiss-Prot
other Location (Reliability: 3)
PLAT1_DANRE
179
1
19845
Swiss-Prot
other Location (Reliability: 2)
Q32PR6_DANRE
528
0
60213
TrEMBL
Secretory Pathway (Reliability: 1)
F1QWF8_DANRE
741
0
83810
TrEMBL
other Location (Reliability: 3)
A0A0R4ICC9_DANRE
720
0
81916
TrEMBL
other Location (Reliability: 2)
Q6P033_DANRE
231
0
25202
TrEMBL
Secretory Pathway (Reliability: 1)
Q6PBK9_DANRE
222
0
25009
TrEMBL
other Location (Reliability: 2)
F1Q5L4_DANRE
717
0
81577
TrEMBL
other Location (Reliability: 2)
A8KBP6_DANRE
153
0
17431
TrEMBL
Secretory Pathway (Reliability: 4)
A0A2R8RYP7_DANRE
824
0
91323
TrEMBL
Mitochondrion (Reliability: 3)
A0A8M1NH23_DANRE
151
0
17140
TrEMBL
Secretory Pathway (Reliability: 1)
B3DFL0_DANRE
741
0
83809
TrEMBL
other Location (Reliability: 3)
Q6NWY0_DANRE
818
0
90692
TrEMBL
other Location (Reliability: 4)
H0WE43_DANRE
824
0
91393
TrEMBL
Mitochondrion (Reliability: 3)
A0A2R8Q8M1_DANRE
232
0
26120
TrEMBL
other Location (Reliability: 3)
A0A8M1N093_DANRE
153
0
17378
TrEMBL
Secretory Pathway (Reliability: 4)
A0A286Y8H5_DANRE
793
0
87667
TrEMBL
other Location (Reliability: 4)
A0A2R8QA71_DANRE
232
0
26090
TrEMBL
other Location (Reliability: 3)
X1WDX0_DANRE
837
0
94453
TrEMBL
other Location (Reliability: 2)
K7DYE2_DANRE
1069
1
119184
TrEMBL
Secretory Pathway (Reliability: 1)
Q5RIP7_DANRE
697
0
79504
TrEMBL
other Location (Reliability: 1)
Q6DHQ7_DANRE
153
0
17378
TrEMBL
Secretory Pathway (Reliability: 4)
F1QXU0_DANRE
818
0
90678
TrEMBL
other Location (Reliability: 4)
A9C458_DANRE
151
0
17140
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8M1NBY8_DANRE
198
0
21995
TrEMBL
Secretory Pathway (Reliability: 2)
Q1LWA7_DANRE
818
0
90608
TrEMBL
other Location (Reliability: 4)
Q568J4_DANRE
311
0
35989
TrEMBL
other Location (Reliability: 1)
X1WH93_DANRE
809
0
91698
TrEMBL
other Location (Reliability: 5)
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
the transcript is readily detectable at 12 h postfertilization and continues to be expressed at similar level until 72 h, after which the expression declines dramatically. Protein expression is detectable at 12 h, with peak expression occurring between 24 and 34 h postfertilization
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pharmacology
pharmacological targeting of the enzyme may have important therapeutic benefits in disease mechanisms that involve excessive cell proliferation, in particular, cancer and proliferative glomerulopathies
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Naini, S.M.; Choukroun, G.J.; Ryan, J.R.; Hentschel, D.M.; Shah, J.V.; Bonventre, J.V.
Cytosolic phospholipase A2alpha regulates G1 progression through modulating FOXO1 activity
FASEB J.
30
1155-1170
2016
Mus musculus (P47713), Mus musculus, Danio rerio (P50392), Danio rerio
Manually annotated by BRENDA team