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Information on EC 3.1.1.34 - lipoprotein lipase and Organism(s) Homo sapiens

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EC Tree
     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.1 Carboxylic-ester hydrolases
                3.1.1.34 lipoprotein lipase
IUBMB Comments
Hydrolyses triacylglycerols and diacylglycerol in chylomicrons and low-density lipoprotein particles. Human protein purified from post-heparin plasma (LPL) shows no activity against triglyceride in the absence of added lipoprotein. The principal reaction sequence of that enzyme is triglyceride -> 1,2-diglyceride -> 2-monoglyceride. The hepatic enzyme (LIPC) also hydrolyses triglycerides and phospholipids present in circulating plasma lipoproteins.
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This record set is specific for:
Homo sapiens
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Word Map
The taxonomic range for the selected organisms is: Homo sapiens
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
lipoprotein lipase, adipose tissue lpl, dag lipase, diglyceride lipase, clearing factor, postheparin lipase, postheparin esterase, placental lipoprotein lipase, diacylglycerol hydrolase, triacylglycero-protein acylhydrolase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
adipose tissue LPL
-
clearing factor
-
-
-
-
diacylglycerol hydrolase
-
-
-
-
diacylglycerol lipase
-
-
-
-
diglyceride lipase
-
-
-
-
lipemia-clearing factor
-
-
-
-
LIPL
-
-
lipoprotein lipase
-
placental lipoprotein lipase
-
postheparin esterase
-
-
-
-
postheparin lipase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of carboxylic ester
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-
SYSTEMATIC NAME
IUBMB Comments
triacylglycero-protein acylhydrolase
Hydrolyses triacylglycerols and diacylglycerol in chylomicrons and low-density lipoprotein particles. Human protein purified from post-heparin plasma (LPL) shows no activity against triglyceride in the absence of added lipoprotein. The principal reaction sequence of that enzyme is triglyceride -> 1,2-diglyceride -> 2-monoglyceride. The hepatic enzyme (LIPC) also hydrolyses triglycerides and phospholipids present in circulating plasma lipoproteins.
CAS REGISTRY NUMBER
COMMENTARY hide
9004-02-8
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
1,2-di-O-lauryl-rac-glycero-3-(glutaric acid 6-methylresorufin ester) + H2O
?
show the reaction diagram
DGGR, a synthetic substrate that produces a fluorescent signal upon hydrolysis
-
-
?
1,2-O-dilauryl-rac-glycero-3-glutaric acid-(6'-methylresorufin) ester + H2O
?
show the reaction diagram
-
-
-
-
?
chylomicron + H2O
?
show the reaction diagram
chylomicrons + H2O
?
show the reaction diagram
-
-
-
-
?
low-density lipoprotein + H2O
?
show the reaction diagram
-
low activity
-
-
?
p-nitrophenyl butyrate + H2O
p-nitrophenol + butyric acid
show the reaction diagram
-
-
-
-
?
triacylglycerol + H2O
diacylglycerol + a carboxylate
show the reaction diagram
tributyrin + H2O
?
show the reaction diagram
-
-
-
?
triolein + H2O
?
show the reaction diagram
triolein + H2O
dioleylglycerol + oleate
show the reaction diagram
-
mutant D204 E, very low activity in presence of emulsifier Triton X-100 or phosphatidylcholine. In presence of phosphatidylethenolamine, phospatidylserine, and cardiolipin as emulsifier, triolein-hydrolizing activity of the mutant is higher than wild-type activity
-
-
?
triolein + H2O
oleate + diolein
show the reaction diagram
very low density protein + H2O
?
show the reaction diagram
-
-
-
?
very-low-density lipoprotein + H2O
?
show the reaction diagram
-
-
-
-
?
very-low-density lipoproteins + H2O
?
show the reaction diagram
-
-
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
triacylglycerol + H2O
diacylglycerol + a carboxylate
show the reaction diagram
additional information
?
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
apolipoprotein CII
important cofactor
-
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-mercaptoethanol
-
-
3-[4'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)biphenyl-3-yl]propanoic acid
-
4-ethylphenylboronic acid
-
4-nonylphenylboronic acid
-
4-tert-butyl-N-[4-(5-methoxy-2-oxo-1,3,4-oxadiazol-3(2H)-yl)phenyl]benzamide
-
5,5'-dithiobis(2-nitrobenzoate)
-
-
angiopoietin-like protein 3
-
angiopoietin-like protein 4
-
antiserum
-
produced in goat
-
apoC-III
-
dithiothreitol
-
-
ethanol
inhibits the enzyme, LPL activity is reduced by 23-25% 2-4 hours after the administration of alcohol, respectively, with respect to controls, in vivo or in post-heparin plasma. The concentrations of inhibitors ANGPTL3 and ANGPTL4 drops to 67% and 86% of baseline values, respectively, at 280 min after alcohol consumption. The acute effects of alcohol consumption, especially on postprandial lipemia, seem to be accentuated in hypertriglyceridemic subjects
HgCl2
-
-
Lys-Gly-Glu-Glu
-
-
NaCl
-
-
p-hydroxymercuribenzoate
-
-
Protamine sulfate
-
-
-
reduced glutathione
-
-
additional information
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
apoC-II
-
apoCII
-
0.002 mg/ml, 25fold activation
-
apolipoprotein C-II
-
apoprotein C II
-
-
-
calnexin
-
promotes formation of active LPL dimers
-
calreticulin
-
promotes formation of active LPL dimers
-
heparin
-
heparin treatment results in an 11.75fold increase of LPL in the cell culture medium
additional information
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
4.74 - 6.09
triacylglycerol
2.5
triolein
-
-
additional information
additional information
-
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.5
3-[4'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)biphenyl-3-yl]propanoic acid
Homo sapiens
pH and temperature not specified in the publication
0.02
4-ethylphenylboronic acid
Homo sapiens
pH and temperature not specified in the publication
0.0014
4-nonylphenylboronic acid
Homo sapiens
pH and temperature not specified in the publication
0.0002
4-tert-butyl-N-[4-(5-methoxy-2-oxo-1,3,4-oxadiazol-3(2H)-yl)phenyl]benzamide
Homo sapiens
pH and temperature not specified in the publication
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
1.7
-
substrate tributyrin
333.3
-
-
39.2
-
substrate triolein
431.6
-
-
47.75
-
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pI VALUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6.8 - 8.6
-
isoelectric focusing
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
decreased to 78% and 73% of baseline values 2 h and 4 h after glucose administration, respectively
Manually annotated by BRENDA team
-
GPIHBP1 shuttles lipoprotein lipase from subendothelial spaces to the capillary lumen
Manually annotated by BRENDA team
noncancer tissue. Lipoprotein lipase activity is higher in cancer tissue than in noncancer tissue. Lipoprotein lipase gene expression is higher in noncancer tissue compared to cancer tissue
Manually annotated by BRENDA team
-
in the mammary gland, synthesis of LpL is induced during late pregnancy and lactation
Manually annotated by BRENDA team
-
postheparin
Manually annotated by BRENDA team
-
highest expression is found in white adipose tissue
Manually annotated by BRENDA team
additional information
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
metabolism
-
the phosphoinositide-3-kinase pathway is involved in the regulation of LPL gene transcription through Sp1/Sp3, signalling pathways that impact on the IFN-mediated regulation of Sp1/Sp3 binding and LPL gene transcription in macrophages, overview. The synergism between IFN- and TNF- on LPL gene transcription is not mediated at the level of Sp1/Sp3 DNA binding
physiological function
additional information
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
LIPL_HUMAN
475
0
53162
Swiss-Prot
Secretory Pathway (Reliability: 1)
A0A1B1RVA9_HUMAN
475
0
53162
TrEMBL
Secretory Pathway (Reliability: 1)
B3KRV7_HUMAN
461
0
51736
TrEMBL
Secretory Pathway (Reliability: 5)
Q6IAV0_HUMAN
475
0
53213
TrEMBL
Secretory Pathway (Reliability: 2)
A8K2M5_HUMAN
475
0
53195
TrEMBL
Secretory Pathway (Reliability: 2)
Q53HW6_HUMAN
475
0
53191
TrEMBL
Secretory Pathway (Reliability: 1)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
55000
-
2 * 55000, dissociation of the dimer into monomers leads to irreversible loss of activity
56000
-
x * 56000, SDS-PAGE
58000
-
x * 58000, SDS-PAGE
60500
-
x * 60500, SDS-PAGE
67000
-
gel filtration
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
dimer
homodimer
dissociation of the dimeric form to the monomeric form is associated with a conformational change of the molecule and irreversible loss of catalytic activity
monomer
-
1 * 67000, SDS-PAGE
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
glycoprotein
side-chain modification
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
C418Y
-
the mutation abolishes lipoprotein lipases's ability to bind to GPIHBP1 and therefore abolishes LPL transport across endothelial cells byGPIHBP1, without interfering with the enzyme catalytic activity or binding to heparin
D204E
-
homozygous missense mutation identified in a patient with severe hypertriglyceridemia, post-heparin enzyme mass is almost normal, but the enzyme activity is remarkably decreased. In presence of phosphatidylethenolamine, phospatidylserine, and cardiolipin as emulsifier, triolein-hydrolizing activity of the mutant is higher than wild-type activity
D9N
the mutation is associated with partial changes in enzyme function, plasma high density lipoprotein-C, triglyceride levels, and differential susceptibility to cardiovascular disease
E421K
-
the mutation abolishes lipoprotein lipases's ability to bind to GPIHBP1 and therefore abolishes LPL transport across endothelial cells byGPIHBP1, without interfering with the enzyme catalytic activity or binding to heparin
K430A/R432A/K434A/K440A/K441A
-
the mutant LPL has little or no ability to bind to GPIHBP1 on the surface of cells
N291S
the mutation is associated with partial changes in enzyme function, plasma high density lipoprotein-C, triglyceride levels, and differential susceptibility to cardiovascular disease
S447X
additional information
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
25
-
no loss of activity after 30 min
37
-
30% loss of activity after 30 min
40
-
20 min, 50% loss of activity
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
heparin has a limited role in stabilizing the bound LPL active dimers
-
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
partial
-
partially purified by heparin-Sepharose column chromatography
-
partially purified using heparin-Sepharose affinity column chromatography
-
recombinant wild-type and mutant enzymes by heparin affinity chromatography
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
chimeric lipase consisting of the amino-terminal 314 amino acids of human lipoprotein lipase and the carboxyl-terminal 146 amino acids of human hepatic lipase
-
expressed in HEK-293 cells
-
expressed in J-774 cells
-
expressed in Mus musculus
-
expressed in Mus musculus mammary glands (milk)
-
expression in COS cells
-
expression in HEK 293 cells
-
expression in rabbit inhibits diet-induced hypercholesterolemia and atherosclerosis
-
expression in Sf21 insect cells, coexpression with calreticulin enhances yield of active LPL by a factor 9
-
expression of LPL mini gene in mice
-
fusion protein consisting of the complete lipoprotein lipase molecule and the mature form of apolipoprotein CII, expression in human embryonic kidney 293 cells
-
gene Lpl, quantitative real-time PCR enzyme expression analysis
gene Lpl, real-time PCR enzyme expression analysis
LPL overexpression in Mus musculus skeletal muscle increases cold tolerance by enhancing capacity for fat oxidation, producing an avian-like phenotype in which skeletal muscle contributes significantly to the thermogenic response to cold temperatures
-
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
interferon mediates inhibition of lipoprotein lipase gene transcription in macrophages, the mechanism involves a reduction in the binding of transcription factors Sp1 and Sp3 to regulatory sequences in the LPL gene with casein kinase 2- and phosphoinositide-3-kinase-mediated regulation of transcription factors Sp1 and Sp3, overview
-
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Augustin, J.; Freeze, H.; Tejada, P.; Brown, W.V.
A comparison of molecular properties of hepatic triglyceride lipase and lipoprotein lipase from human post-heparin plasma
J. Biol. Chem.
253
2912-2920
1978
Homo sapiens
Manually annotated by BRENDA team
Davis, R.C.; Wong, H.; Nikazy, J.; Wang, K.; Han, Q.; Schotz, M.C.
Chimeras of hepatic lipase and lipoprotein lipase. Domain localization of enzyme-specific properties
J. Biol. Chem.
267
21499-21504
1992
Homo sapiens
Manually annotated by BRENDA team
Dichek, H.L.; Parrott, C.; Ronan, R.; Brunzell, J.D.; Brewer, H.B.; Santamarina-Fojo, S.
Functional characterization of a chimeric lipase genetically engineered from human lipoprotein lipase and human hepatic lipase
J. Lipid Res.
34
1393-1401
1993
Homo sapiens
Manually annotated by BRENDA team
Wong, H.; Davis, R.C.; Nikazy, J.; Seebart, K.E.; Schotz, M.C.
Domain exchange: characterization of a chimeric lipase of hepatic lipase and lipoprotein lipase
Proc. Natl. Acad. Sci. USA
88
11290-11294
1991
Homo sapiens
Manually annotated by BRENDA team
Iverius, P.H.; stlund-Lindqvist, A.M.
Preparation, characterization, and measurement of lipoprotein lipase
Methods Enzymol.
129
691-704
1986
Bos taurus, Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Hayashi, R.; Tajima, S.; Yamamoto, A.
Purification and characterization of lipoprotein lipase from human postheparin plasma and its comparison with purified bovine milk lipoprotein lipase
J. Biochem.
100
319-331
1986
Bos taurus, Homo sapiens
Manually annotated by BRENDA team
Bengtsson-Olivecrona, G.; Olivecrona, T.; Jrnvall, H.
Lipoprotein lipases from cow, guinea-pig and man. Structural characterization and identification of protease-sensitive internal regions
Eur. J. Biochem.
161
281-288
1986
Bos taurus, Cavia porcellus, Homo sapiens
Manually annotated by BRENDA team
Cheng, C.F.; Bensadoun, A.; Bersot, T.; Hsu, J.S.; Melford, K.H.
Purification and characterization of human lipoprotein lipase and hepatic triglyceride lipase. Reactivity with monoclonal antibodies to hepatic triglyceride lipase
J. Biol. Chem.
260
10720-10727
1985
Homo sapiens
Manually annotated by BRENDA team
Becht, I.; Schrecker, O.; Klose, G.; Greten, H.
Purification of human plasma lipoprotein lipase
Biochim. Biophys. Acta
620
583-591
1980
Homo sapiens
Manually annotated by BRENDA team
Hoffmann, M.H.; Stoffel, W.
Construction and functional characterization of recombinant fusion proteins of human lipoprotein lipase and apolipoprotein CII
Eur. J. Biochem.
237
545-552
1996
Homo sapiens
Manually annotated by BRENDA team
Wang, C.S.; Hartsuck, J.; McConathy, J.
Structure and functional properties of lipoprotein lipase
Biochim. Biophys. Acta
1123
1-17
1992
Bos taurus, Cavia porcellus, Gallus gallus, Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Goldberg, I.J.; Blaner, W.S.; Goodman, D.S.
Immunologic and enzymatic comparisons between human and bovine lipoprotein lipase
Arch. Biochem. Biophys.
244
580-584
1986
Bos taurus, Homo sapiens
Manually annotated by BRENDA team
Kidani, T.; Sakayama, K.; Masuno, H.; Takubo, N.; Matsuda, Y.; Okuda, H.; Yamamoto, H.
Active-dimeric form of lipoprotein lipase increases in the adipose tissue of patients with rheumatoid arthritis treated with prednisolone
Biochim. Biophys. Acta
1584
31-36
2002
Homo sapiens
Manually annotated by BRENDA team
Esenabhalu, V.E.; Cerimagic, M.; Malli, R.; Osibow, K.; Levak-Frank, S.; Frieden, M.; Sattler, W.; Kostner, G.M.; Zechner, R.; Graier, W.F.
Tissue-specific expression of human lipoprotein lipase in the vascular system affects vascular reactivity in transgenic mice
Br. J. Pharmacol.
135
143-154
2002
Homo sapiens
Manually annotated by BRENDA team
Lindberg, A.; Olivecrona, G.
Lipoprotein lipase from rainbow trout differs in several respects from the enzyme in mammals
Gene
292
213-223
2002
Bos taurus, Homo sapiens, Oncorhynchus mykiss (Q9W6Y2), Oncorhynchus mykiss
Manually annotated by BRENDA team
Fan, J.; Unoki, H.; Kojima, N.; Sun, H.; Shimoyamada, H.; Deng, H.; Okazaki, M.; Shikama, H.; Yamada, N.; Watanabe, T.
Overexpression of lipoprotein lipase in transgenic rabbits inhibits diet-induced hypercholesterolemia and atherosclerosis
J. Biol. Chem.
276
40071-40079
2001
Homo sapiens
Manually annotated by BRENDA team
Zhang, L.; Wu, G.; Tate, C.G.; Lookene, A.; Olivecrona, G.
Calreticulin promotes folding/dimerization of human lipoprotein lipase expressed in insect cells (sf21)
J. Biol. Chem.
278
29344-29351
2003
Homo sapiens
Manually annotated by BRENDA team
Keiper, T.; Schneider, J.G.; Dugi, K.A.
Novel site in lipoprotein lipase (LPL415-438) essential for substrate interaction and dimer stability
J. Lipid Res.
42
1180-1186
2001
Homo sapiens
Manually annotated by BRENDA team
McCoy, M.G.; Sun, G.S.; Marchadier, D.; Maugeais, C.; Glick, J.M.; Rader, D.J.
Characterization of the lipolytic activity of endothelial lipase
J. Lipid Res.
43
921-929
2002
Homo sapiens
Manually annotated by BRENDA team
Murano, T.; Sako, T.; Oikawa, S.; Shirai, K.
The recovery of dysfunctional lipoprotein lipase (Asp204-Glu) activity by modification of substrate
Atherosclerosis
183
101-107
2005
Homo sapiens
Manually annotated by BRENDA team
Kobayashi, J.; Kusunoki, M.; Murase, Y.; Kawashiri, M.; Higashikata, T.; Miwa, K.; Katsuda, S.; Takata, M.; Asano, A.; Nohara, A.; Inazu, A.; Mabuchi, H.
Relationship of lipoprotein lipase and hepatic triacylglycerol lipase activity to serum adiponectin levels in Japanese hyperlipidemic men
Horm. Metab. Res.
37
505-509
2005
Homo sapiens
Manually annotated by BRENDA team
Kiens, B.; Roepstorff, C.; Glatz, J.F.; Bonen, A.; Schjerling, P.; Knudsen, J.; Nielsen, J.N.
Lipid-binding proteins and lipoprotein lipase activity in human skeletal muscle: influence of physical activity and gender
J. Appl. Physiol.
97
1209-1218
2004
Homo sapiens
Manually annotated by BRENDA team
Kota, R.S.; Ramana, C.V.; Tenorio, F.A.; Enelow, R.I.; Rutledge, J.C.
Differential effects of lipoprotein lipase on tumor necrosis factor-alpha and interferon-gamma-mediated gene expression in human endothelial cells
J. Biol. Chem.
280
31076-31084
2005
Homo sapiens
Manually annotated by BRENDA team
Liu, E.; Kitajima, S.; Higaki, Y.; Morimoto, M.; Sun, H.; Watanabe, T.; Yamada, N.; Fan, J.
High lipoprotein lipase activity increases insulin sensitivity in transgenic rabbits
Metabolism
54
132-138
2005
Homo sapiens
Manually annotated by BRENDA team
Jindrichova, E.; Kratochvilova, S.; Kovar, J.
Glucose administration downregulates lipoprotein lipase activity in vivo. A study using repeated intravenous fat tolerance test
Physiol. Res.
0
1-19
2006
Homo sapiens
Manually annotated by BRENDA team
Andreo, U.; Maillard, P.; Kalinina, O.; Walic, M.; Meurs, E.; Martinot, M.; Marcellin, P.; Budkowska, A.
Lipoprotein lipase mediates hepatitis C virus (HCV) cell entry and inhibits HCV infection
Cell. Microbiol.
9
2445-2456
2007
Homo sapiens, Bos taurus (P11151)
Manually annotated by BRENDA team
Cerne, D.; Melkic, E.; Trost, Z.; Sok, M.; Marc, J.
Lipoprotein lipase activity and gene expression in lung cancer and in adjacent noncancer lung tissue
Exp. Lung Res.
33
217-225
2007
Homo sapiens (P06858), Homo sapiens
Manually annotated by BRENDA team
Griffon, N.; Budreck, E.C.; Long, C.J.; Broedl, U.C.; Marchadier, D.H.; Glick, J.M.; Rader, D.J.
Substrate specificity of lipoprotein lipase and endothelial lipase: studies of lid chimeras
J. Lipid Res.
47
1803-1811
2006
Homo sapiens
Manually annotated by BRENDA team
Jindrichova, E.; Kratochvilova, S.; Kovar, J.
Glucose administration downregulates lipoprotein lipase activity in vivo: a study using repeated intravenous fat tolerance test
Physiol. Res.
56
175-181
2007
Homo sapiens
Manually annotated by BRENDA team
Sakayama, K.; Kidani, T.; Tanji, N.; Yamamoto, H.; Masuno, H.
The synthesis and activity of lipoprotein lipase in the subcutaneous adipose tissue of patients with musculoskeletal sarcomas
Anticancer Res.
28
2081-2086
2008
Homo sapiens
Manually annotated by BRENDA team
Takahashi, M.; Hiyama, Y.; Yokoyama, M.; Yu, S.; Hu, Y.; Melford, K.; Bensadoun, A.; Goldberg, I.J.
In vivo arterial lipoprotein lipase expression augments inflammatory responses and impairs vascular dilatation
Arterioscler. Thromb. Vasc. Biol.
28
455-462
2008
Homo sapiens
Manually annotated by BRENDA team
Chen, P.; Jou, Y.S.; Fann, C.S.; Chen, J.W.; Chung, C.M.; Lin, C.Y.; Wu, S.Y.; Kang, M.J.; Chen, Y.C.; Jong, Y.S.; Lo, H.M.; Kang, C.S.; Chen, C.C.; Chang, H.C.; Huang, N.K.; Wu, Y.L.; Pan, W.H.
Lipoprotein lipase variants associated with an endophenotype of hypertension: hypertension combined with elevated triglycerides
Hum. Mutat.
30
49-55
2009
Homo sapiens
Manually annotated by BRENDA team
Tory, R.; Sachs-Barrable, K.; Hill, J.S.; Wasan, K.M.
Cyclosporine A and rapamycin induce in vitro cholesteryl ester transfer protein activity, and suppress lipoprotein lipase activity in human plasma
Int. J. Pharm.
358
219-223
2008
Homo sapiens
Manually annotated by BRENDA team
Gin, P.; Yin, L.; Davies, B.S.; Weinstein, M.M.; Ryan, R.O.; Bensadoun, A.; Fong, L.G.; Young, S.G.; Beigneux, A.P.
The acidic domain of GPIHBP1 is important for the binding of lipoprotein lipase and chylomicrons
J. Biol. Chem.
283
29554-29562
2008
Homo sapiens
Manually annotated by BRENDA team
Shan, L.; Yu, X.C.; Liu, Z.; Hu, Y.; Sturgis, L.T.; Miranda, M.L.; Liu, Q.
The angiopoietin-like proteins ANGPTL3 and ANGPTL4 inhibit lipoprotein lipase activity through distinct mechanisms
J. Biol. Chem.
284
1419-1424
2009
Homo sapiens
Manually annotated by BRENDA team
Chang, Y.T.; Chang, M.C.; Su, T.C.; Liang, P.C.; Su, Y.N.; Kuo, C.H.; Wei, S.C.; Wong, J.M.
Lipoprotein lipase mutation S447X associated with pancreatic calcification and steatorrhea in hyperlipidemic pancreatitis
J. Clin. Gastroenterol.
43
591-596
2009
Homo sapiens
Manually annotated by BRENDA team
Imamura, S.; Kobayashi, J.; Nakajima, K.; Sakasegawa, S.; Nohara, A.; Noguchi, T.; Kawashiri, M.A.; Inazu, A.; Deeb, S.S.; Mabuchi, H.; Brunzell, J.D.
A novel method for measuring human lipoprotein lipase and hepatic lipase activities in postheparin plasma
J. Lipid Res.
49
1431-1437
2008
Homo sapiens
Manually annotated by BRENDA team
Maingrette, F.; Li, L.; Renier, G.
C-reactive protein enhances macrophage lipoprotein lipase expression
J. Lipid Res.
49
1926-1935
2008
Homo sapiens
Manually annotated by BRENDA team
Jensen, D.R.; Knaub, L.A.; Konhilas, J.P.; Leinwand, L.A.; MacLean, P.S.; Eckel, R.H.
Increased thermoregulation in cold-exposed transgenic mice overexpressing lipoprotein lipase in skeletal muscle: an avian phenotype?
J. Lipid Res.
49
870-879
2008
Homo sapiens
Manually annotated by BRENDA team
Goldberg, I.G.; Eckel, R.H.; Abumrad, N.A.
Regulation of fatty acid uptake into tissues: lipoprotein lipase- and CD36-mediated pathways
J. Lipid Res.
50
S86-S90
2009
Homo sapiens
Manually annotated by BRENDA team
Glisic, S.; Arrigo, P.; Alavantic, D.; Perovic, V.; Prljic, J.; Veljkovic, N.
Lipoprotein lipase: A bioinformatics criterion for assessment of mutations as a risk factor for cardiovascular disease
Proteins Struct. Funct. Bioinform.
70
855-862
2008
Homo sapiens (P06858)
Manually annotated by BRENDA team
Harris, S.M.; Harvey, E.J.; Hughes, T.R.; Ramji, D.P.
The interferon- -mediated inhibition of lipoprotein lipase gene transcription in macrophages involves casein kinase 2- and phosphoinositide-3-kinase-mediated regulation of transcription factors Sp1 and Sp3
Cell. Signal.
20
2296-2301
2008
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Holmes, R.S.; Vandeberg, J.L.; Cox, L.A.
Comparative studies of vertebrate lipoprotein lipase: a key enzyme of very low density lipoprotein metabolism
Comp. Biochem. Physiol. D
6
224-234
2011
Homo sapiens
Manually annotated by BRENDA team
Nielsen, J.; Lindegaard, M.; Friis-Hansen, L.; Almstrup, K.; Leffers, H.; Nielsen, L.; Rajpert-De Meyts, E.
Lipoprotein lipase and endothelial lipase in human testis and in germ cell neoplasms
Int. J. Androl.
33
e207-e215
2010
Homo sapiens
Manually annotated by BRENDA team
Wang, Y.; Tong, J.; Li, S.; Zhang, R.; Chen, L.; Wang, Y.; Zheng, M.; Wang, M.; Liu, G.; Dai, Y.; Zhao, Y.; Li, N.
Over-expression of human lipoprotein lipase in mouse mammary glands leads to reduction of milk triglyceride and delayed growth of suckling pups
PLoS ONE
6
e20895
2011
Homo sapiens
Manually annotated by BRENDA team
Voss, C.V.; Davies, B.S.; Tat, S.; Gin, P.; Fong, L.G.; Pelletier, C.; Mottler, C.D.; Bensadoun, A.; Beigneux, A.P.; Young, S.G.
Mutations in lipoprotein lipase that block binding to the endothelial cell transporter GPIHBP1
Proc. Natl. Acad. Sci. USA
108
7980-7984
2011
Homo sapiens
Manually annotated by BRENDA team
Badia-Villanueva, M.; Carulla, P.; Carrascal, M.; Abian, J.; Llobera, M.; Casanovas, A.; Dolores Lopez-Tejero, M.
Lipoprotein lipase isoelectric point isoforms in humans
Biochem. Biophys. Res. Commun.
445
480-485
2014
Homo sapiens
Manually annotated by BRENDA team
Wang, Z.; Li, S.; Sun, L.; Fan, J.; Liu, Z.
Comparative analyses of lipoprotein lipase, hepatic lipase, and endothelial lipase, and their binding properties with known inhibitors
PLoS ONE
8
e72146
2013
Homo sapiens (P06858)
Manually annotated by BRENDA team
Hayne, C.K.; Lafferty, M.J.; Eglinger, B.J.; Kane, J.P.; Neher, S.B.
Biochemical analysis of the lipoprotein lipase truncation variant, LPLS447X, reveals increased lipoprotein uptake
Biochemistry
56
525-533
2017
Homo sapiens (P06858)
Manually annotated by BRENDA team
Bruce, K.D.; Gorkhali, S.; Given, K.; Coates, A.M.; Boyle, K.E.; Macklin, W.B.; Eckel, R.H.
Lipoprotein lipase is a feature of alternatively-activated microglia and may facilitate lipid uptake in the CNS during demyelination
Front. Mol. Neurosci.
11
57
2018
Homo sapiens (P06858), Homo sapiens, Mus musculus (P11152), Mus musculus C57BL/6J (P11152)
Manually annotated by BRENDA team
Reimund, M.; Kovrov, O.; Olivecrona, G.; Lookene, A.
Lipoprotein lipase activity and interactions studied in human plasma by isothermal titration calorimetry
J. Lipid Res.
58
279-288
2017
Homo sapiens (P06858), Homo sapiens
Manually annotated by BRENDA team
Mahat, B.; Chasse, E.; Mauger, J.F.; Imbeault, P.
Effects of acute hypoxia on human adipose tissue lipoprotein lipase activity and lipolysis
J. Transl. Med.
14
212
2016
Homo sapiens (P06858), Homo sapiens
Manually annotated by BRENDA team
Zemankova, K.; Makoveichuk, E.; Vlasakova, Z.; Olivecrona, G.; Kovar, J.
Acute alcohol consumption downregulates lipoprotein lipase activity in vivo
Metab. Clin. Exp.
64
1592-1596
2015
Homo sapiens (P06858)
Manually annotated by BRENDA team
Heerwagen, M.J.R.; Gumina, D.L.; Hernandez, T.L.; Van Pelt, R.E.; Kramer, A.W.; Janssen, R.C.; Jensen, D.R.; Powell, T.L.; Friedman, J.E.; Winn, V.D.; Barbour, L.A.
Placental lipoprotein lipase activity is positively associated with newborn adiposity
Placenta
64
53-60
2018
Homo sapiens (P06858)
Manually annotated by BRENDA team
Soendergaard, E.; Andersen, I.R.; Soerensen, L.P.; Gormsen, L.C.; Nielsen, S.
Lipoprotein lipase activity does not predict very low-density lipoprotein-triglyceride fatty acid oxidation during exercise
Scand. J. Med. Sci. Sports
27
474-481
2017
Homo sapiens (P06858), Homo sapiens
Manually annotated by BRENDA team