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Information on EC 2.8.3.5 - 3-oxoacid CoA-transferase and Organism(s) Gallus gallus

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EC Tree
     2 Transferases
         2.8 Transferring sulfur-containing groups
             2.8.3 CoA-transferases
                2.8.3.5 3-oxoacid CoA-transferase
IUBMB Comments
Acetoacetate and, more slowly, 3-oxopropanoate, 3-oxopentanoate, 3-oxo-4-methylpentanoate or 3-oxohexanoate can act as acceptors; malonyl-CoA can act instead of succinyl-CoA.
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This record set is specific for:
Gallus gallus
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Word Map
The taxonomic range for the selected organisms is: Gallus gallus
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
coa transferase, oxct1, 3-oxoacid coa-transferase, succinyl-coa:3-ketoacid coa transferase, 3-ketoacid coa-transferase, scot-t, succinyl-coa transferase, succinyl-coa:3-oxoacid coa transferase, succinyl-coa:3-ketoacid coenzyme a transferase, succinyl-coa:3-oxoacid coa-transferase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
3-ketoacid CoA-transferase
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-
-
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3-ketoacid coenzyme A transferase
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-
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3-ketoacid coenzyme A-transferase
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-
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3-oxo-CoA transferase
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-
-
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3-oxoacid CoA dehydrogenase
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-
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3-oxoacid coenzyme A-transferase
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-
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acetoacetate succinyl-CoA transferase
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-
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acetoacetyl coenzyme A-succinic thiophorase
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-
-
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coenzyme A-transferase, 3-oxoacid
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-
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SCOT
-
-
-
-
SCOT-t
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-
-
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succinyl coenzyme A-acetoacetyl coenzyme A-transferase
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-
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succinyl-CoA transferase
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succinyl-CoA:acetoacetate CoA transferase
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-
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testis-specific succinyl-CoA:3-oxo-acid CoA-transferase
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
coenzyme A transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
succinyl-CoA:3-oxo-acid CoA-transferase
Acetoacetate and, more slowly, 3-oxopropanoate, 3-oxopentanoate, 3-oxo-4-methylpentanoate or 3-oxohexanoate can act as acceptors; malonyl-CoA can act instead of succinyl-CoA.
CAS REGISTRY NUMBER
COMMENTARY hide
9027-43-4
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
succinyl-CoA + acetoacetate
?
show the reaction diagram
-
liver enzyme: produces a substrate circle between acetoacetyl-CoA and acetoacetate
-
-
?
succinyl-CoA + acetoacetate
succinate + acetoacetyl-CoA
show the reaction diagram
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
succinyl-CoA + acetoacetate
?
show the reaction diagram
-
liver enzyme: produces a substrate circle between acetoacetyl-CoA and acetoacetate
-
-
?
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
25
-
assay at
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
domestic fowl
-
-
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
Q5F3M8_CHICK
517
0
56186
TrEMBL
Mitochondrion (Reliability: 3)
F1N9Z7_CHICK
517
0
56174
TrEMBL
Mitochondrion (Reliability: 3)
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Zammit, V.A.; Beis, A.; Newsholme, E.A.
The role of 3-oxo acid-CoA transferase in the regulation of ketogenesis in the liver
FEBS Lett.
103
212-215
1979
Gallus gallus, Clupea harengus, Columba livia, Oryctolagus cuniculus, Dicentrarchus labrax, Lacerta viridis, Mus musculus, Oncorhynchus mykiss, Pleuronectes platessa, Raja clavata, Rattus norvegicus, Scomber scombrus, Scyliorhinus canicula
Manually annotated by BRENDA team