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Information on EC 2.8.3.5 - 3-oxoacid CoA-transferase and Organism(s) Drosophila melanogaster

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EC Tree
     2 Transferases
         2.8 Transferring sulfur-containing groups
             2.8.3 CoA-transferases
                2.8.3.5 3-oxoacid CoA-transferase
IUBMB Comments
Acetoacetate and, more slowly, 3-oxopropanoate, 3-oxopentanoate, 3-oxo-4-methylpentanoate or 3-oxohexanoate can act as acceptors; malonyl-CoA can act instead of succinyl-CoA.
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This record set is specific for:
Drosophila melanogaster
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Word Map
The taxonomic range for the selected organisms is: Drosophila melanogaster
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
coa transferase, oxct1, 3-oxoacid coa-transferase, succinyl-coa:3-ketoacid coa transferase, 3-ketoacid coa-transferase, succinyl-coa transferase, scot-t, succinyl-coa:3-oxoacid coa transferase, succinyl-coa:3-oxoacid coa-transferase, succinyl-coa:3-ketoacid coenzyme a transferase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
3-ketoacid CoA-transferase
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3-ketoacid coenzyme A transferase
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3-ketoacid coenzyme A-transferase
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3-oxo-CoA transferase
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3-oxoacid CoA dehydrogenase
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3-oxoacid coenzyme A-transferase
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acetoacetate succinyl-CoA transferase
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acetoacetyl coenzyme A-succinic thiophorase
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coenzyme A-transferase, 3-oxoacid
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SCOT-t
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succinyl coenzyme A-acetoacetyl coenzyme A-transferase
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succinyl-CoA transferase
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succinyl-CoA:3-ketoacid CoA transferase
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succinyl-CoA:acetoacetate CoA transferase
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testis-specific succinyl-CoA:3-oxo-acid CoA-transferase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
coenzyme A transfer
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SYSTEMATIC NAME
IUBMB Comments
succinyl-CoA:3-oxo-acid CoA-transferase
Acetoacetate and, more slowly, 3-oxopropanoate, 3-oxopentanoate, 3-oxo-4-methylpentanoate or 3-oxohexanoate can act as acceptors; malonyl-CoA can act instead of succinyl-CoA.
CAS REGISTRY NUMBER
COMMENTARY hide
9027-43-4
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
succinyl-CoA + a 3-oxo acid
succinate + a 3-oxoacyl-CoA
show the reaction diagram
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-
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r
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
succinyl-CoA + a 3-oxo acid
succinate + a 3-oxoacyl-CoA
show the reaction diagram
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-
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r
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
SCOT_DROME
516
0
54904
Swiss-Prot
Mitochondrion (Reliability: 4)
C8VV34_DROME
551
0
59056
TrEMBL
Mitochondrion (Reliability: 4)
M9PGX7_DROME
450
0
47967
TrEMBL
other Location (Reliability: 2)
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
homodimer
x-ray crystallography
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
sitting drop vapor diffusion method, using 0.2 M lithium sulfate, 0.1 M bis-Tris pH 5.5, 25% (w/v) PEG 3350
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
Ni-NTA column chromatography and Superdex 200 gel filtration
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Zhang, M.; Xu, H.Y.; Wang, Y.C.; Shi, Z.B.; Zhang, N.N.
Structure of succinyl-CoA:3-ketoacid CoA transferase from Drosophila melanogaster
Acta Crystallogr. Sect. F
69
1089-1093
2013
Drosophila melanogaster (Q9W058), Drosophila melanogaster
Manually annotated by BRENDA team