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3-hydroxy-3-methylglutaryl-CoA + adipate
3-hydroxy-3-methylglutarate + adipyl-CoA
-
-
-
r
3-hydroxy-3-methylglutaryl-CoA + glutarate
3-hydroxy-3-methylglutarate + glutaryl-CoA
3-hydroxy-3-methylglutaryl-CoA + malonate
3-hydroxy-3-methylglutarate + malonyl-CoA
-
-
-
r
3-hydroxy-3-methylglutaryl-CoA + methylmalonate
3-hydroxy-3-methylglutarate + methylmalonyl-CoA
-
-
-
r
3-hydroxy-3-methylglutaryl-CoA + succinate
3-hydroxy-3-methylglutarate + succinyl-CoA
adipyl-CoA + 3-hydroxy-3-methylglutarate
adipate + 3-hydroxy-3-methylglutaryl-CoA
adipyl-CoA + glutarate
adipate + glutaryl-CoA
-
forward reaction at 82%, reverse reaction at 68% the rate of the CoA-transfer between adipyl-CoA and succinate
-
r
adipyl-CoA + malonate
adipate + malonyl-CoA
-
forward reaction at 40%, reverse reaction at 43% the rate of the CoA-transfer between adipyl-CoA and succinate
-
r
adipyl-CoA + methylmalonate
adipate + methylmalonyl-CoA
-
poor substrate, succinyl-CoA, glutaryl-CoA, malonyl-CoA or 3-hydroxy-3-methylglutaryl-CoA can replace adipyl-CoA
-
r
adipyl-CoA + succinate
adipate + succinyl-CoA
-
best substrates, reverse reaction at 38% the rate of forward reaction
-
r
butyryl-CoA + 3-hydroxy-3-methylglutarate
butyrate + 3-hydroxy-3-methylglutaryl-CoA
-
only negligible amounts of HMGCoA produced
-
?
glutaryl-CoA + 3-hydroxy-3-methylglutarate
glutarate + 3-hydroxy-3-methylglutaryl-CoA
-
forward and reverse reaction at 50% the rate of the CoA-transfer between adipyl-CoA and succinate
-
r
glutaryl-CoA + adipate
glutarate + adipyl-CoA
-
-
-
r
glutaryl-CoA + malonate
glutarate + malonyl-CoA
-
forward reaction at 33%, reverse reaction at 41% the rate of the CoA-transfer between adipyl-CoA and succinate
-
r
glutaryl-CoA + methylmalonate
glutarate + methylmalonyl-CoA
-
-
-
r
glutaryl-CoA + succinate
glutarate + succinyl-CoA
-
-
-
r
malonyl-CoA + 3-hydroxy-3-methylglutarate
malonate + 3-hydroxy-3-methylglutaryl-CoA
malonyl-CoA + adipate
malonate + adipyl-CoA
-
-
-
r
malonyl-CoA + glutarate
malonate + glutaryl-CoA
-
-
-
r
malonyl-CoA + methylmalonate
malonate + methylmalonyl-CoA
-
-
-
r
malonyl-CoA + succinate
malonate + succinyl-CoA
-
-
-
r
methylmalonyl-CoA + 3-hydroxy-3-methylglutarate
methylmalonate + 3-hydroxy-3-methylglutaryl-CoA
-
-
-
r
methylmalonyl-CoA + adipate
methylmalonate + adipyl-CoA
-
-
-
r
methylmalonyl-CoA + glutarate
methylmalonate + glutaryl-CoA
-
-
-
r
methylmalonyl-CoA + malonate
methylmalonate + malonyl-CoA
-
-
-
r
methylmalonyl-CoA + succinate
methylmalonate + succinyl-CoA
-
-
-
r
succinyl-CoA + 3-hydroxy-3-methylglutarate
succinate + 3-hydroxy-3-methylglutaryl-CoA
succinyl-CoA + adipate
succinate + adipyl-CoA
-
-
-
r
succinyl-CoA + glutarate
succinate + glutaryl-CoA
-
forward reaction at 58%, reverse reaction at 55% the rate of the CoA-transfer between adipyl-CoA and succinate
-
r
succinyl-CoA + malonate
succinate + malonyl-CoA
-
forward reaction at 29%, reverse reaction at 22% the rate of the CoA-transfer between adipyl-CoA and succinate
-
r
succinyl-CoA + methylmalonate
succinate + methylmalonyl-CoA
-
-
-
r
additional information
?
-
3-hydroxy-3-methylglutaryl-CoA + glutarate
3-hydroxy-3-methylglutarate + glutaryl-CoA
highest activity
-
-
?
3-hydroxy-3-methylglutaryl-CoA + glutarate
3-hydroxy-3-methylglutarate + glutaryl-CoA
-
-
-
r
3-hydroxy-3-methylglutaryl-CoA + succinate
3-hydroxy-3-methylglutarate + succinyl-CoA
-
-
-
?
3-hydroxy-3-methylglutaryl-CoA + succinate
3-hydroxy-3-methylglutarate + succinyl-CoA
-
-
-
r
adipyl-CoA + 3-hydroxy-3-methylglutarate
adipate + 3-hydroxy-3-methylglutaryl-CoA
-
-
-
r
adipyl-CoA + 3-hydroxy-3-methylglutarate
adipate + 3-hydroxy-3-methylglutaryl-CoA
-
adipyl-CoA shows highest apparent affinty, forward reaction at 64%, reverse reaction at 32% the rate of the CoA-transfer between adipyl-CoA and succinate
-
r
malonyl-CoA + 3-hydroxy-3-methylglutarate
malonate + 3-hydroxy-3-methylglutaryl-CoA
-
-
-
r
malonyl-CoA + 3-hydroxy-3-methylglutarate
malonate + 3-hydroxy-3-methylglutaryl-CoA
-
forward reaction at 34%, reverse reaction at 23% the rate of the CoA-transfer between adipyl-CoA and succinate
-
r
succinyl-CoA + 3-hydroxy-3-methylglutarate
succinate + 3-hydroxy-3-methylglutaryl-CoA
-
-
-
r
succinyl-CoA + 3-hydroxy-3-methylglutarate
succinate + 3-hydroxy-3-methylglutaryl-CoA
-
-
-
r
succinyl-CoA + 3-hydroxy-3-methylglutarate
succinate + 3-hydroxy-3-methylglutaryl-CoA
-
-
-
r
succinyl-CoA + 3-hydroxy-3-methylglutarate
succinate + 3-hydroxy-3-methylglutaryl-CoA
-
involved in regulation of the tricarboxylic acid cycle rate and ketogenesis
-
r
succinyl-CoA + 3-hydroxy-3-methylglutarate
succinate + 3-hydroxy-3-methylglutaryl-CoA
-
involved in regulation of the tricarboxylic acid cycle rate and ketogenesis
-
r
additional information
?
-
adipate, 3-hydroxy-3-methylglutarate and itaconate are at least 10% as good as succinate in a reaction where glutaryl-CoA is used as CoA donor. Other, shorter (malonate, methylmalonate) or more polar (D- and L-2-hydroxyglutarate, malate, alpha-ketoglutarate) are poorer substrates, which react at rates between 1 and 10% of that observed with succinate
-
-
?
additional information
?
-
-
adipate, 3-hydroxy-3-methylglutarate and itaconate are at least 10% as good as succinate in a reaction where glutaryl-CoA is used as CoA donor. Other, shorter (malonate, methylmalonate) or more polar (D- and L-2-hydroxyglutarate, malate, alpha-ketoglutarate) are poorer substrates, which react at rates between 1 and 10% of that observed with succinate
-
-
?
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0.76 - 2.33
3-hydroxy-3-methylglutarate
0.18 - 0.62
3-hydroxy-3-methylglutaryl-CoA
1.95 - 3.05
methylmalonate
0.65 - 0.87
methylmalonyl-CoA
0.75
succinylCoA
-
pH 7.8, 30°C, cosubstrate malonate
0.76
3-hydroxy-3-methylglutarate
-
pH 7.8, 30°C, cosubstrate adipyl-CoA
1.25
3-hydroxy-3-methylglutarate
-
pH 7.8, 30°C, cosubstrate glutaryl-CoA
1.42
3-hydroxy-3-methylglutarate
-
pH 7.8, 30°C, cosubstrate succinyl-CoA
1.7
3-hydroxy-3-methylglutarate
-
pH 8.5, 30°C
1.78
3-hydroxy-3-methylglutarate
-
pH 7.8, 30°C
1.8
3-hydroxy-3-methylglutarate
-
pH 7.8, 30°C, cosubstrate malonyl-CoA
2.33
3-hydroxy-3-methylglutarate
-
pH 7.8, 30°C, cosubstrate methylmalonyl-CoA
0.18
3-hydroxy-3-methylglutaryl-CoA
-
pH 7.8, 30°C, cosubstrate adipate, reverse reaction
0.32
3-hydroxy-3-methylglutaryl-CoA
-
pH 7.8, 30°C, cosubstrate succinate or malonate, reverse reaction
0.39
3-hydroxy-3-methylglutaryl-CoA
-
pH 7.8, 30°C, cosubstrate succinate or glutarate, reverse reaction
0.62
3-hydroxy-3-methylglutaryl-CoA
-
pH 7.8, 30°C, cosubstrate methylmalonate, reverse reaction
0.39
adipate
-
pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutaryl-CoA , reverse reaction
0.72
adipate
-
pH 7.8, 30°C, cosubstrate glutaryl-CoA
0.83
adipate
-
pH 7.8, 30°C, cosubstrate malonylCoA
1.32
adipate
-
pH 7.8, 30°C, cosubstrate succinylCoA
1.51
adipate
-
pH 7.8, 30°C, cosubstrate methylmalonyl-CoA
0.07
adipyl-CoA
-
pH 7.8, 30°C, cosubstrate glutarate
0.11
adipyl-CoA
-
pH 7.8, 30°C, cosubstrate succinate
0.16
adipyl-CoA
-
pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutarate
0.38
adipyl-CoA
-
pH 7.8, 30°C, cosubstrate malonate
0.4
adipyl-CoA
-
pH 7.8, 30°C, cosubstrate methylmalonate
0.18
Glutarate
-
pH 7.8, 30°C, cosubstrate adipylCoA
0.26
Glutarate
-
pH 7.8, 30°C, cosubstrate malonylCoA
0.45
Glutarate
-
pH 7.8, 30°C, cosubstrate succinylCoA
0.5
Glutarate
-
pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutaryl-CoA
0.84
Glutarate
-
pH 7.8, 30°C, cosubstrate methylmalonylCoA
0.07
glutaryl-CoA
-
pH 7.8, 30°C, cosubstrate adipate
0.18
glutaryl-CoA
-
pH 7.8, 30°C, cosubstrate succinate
0.27
glutaryl-CoA
-
pH 7.8, 30°C, cosubstrate malonate
0.45
glutaryl-CoA
-
pH 7.8, 30°C, cosubstrate methylmalonate
0.73
glutaryl-CoA
-
pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutarate
1.01
malonate
-
pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutaryl-CoA , reverse reaction
1.55
malonate
-
pH 7.8, 30°C, cosubstrate glutaryl-CoA
1.63
malonate
-
pH 7.8, 30°C, cosubstrate succinyl-CoA or methylmalonyl-CoA
1.71
malonate
-
pH 7.8, 30°C, cosubstrate adipyl-CoA
0.13
malonyl-CoA
-
pH 7.8, 30°C, cosubstrate glutarate
0.33
malonyl-CoA
-
pH 7.8, 30°C, cosubstrate adipate
0.37
malonyl-CoA
-
pH 8.5, 30°C, cosubstrate 3-hydroxy-3-methylglutarate
0.52
malonyl-CoA
-
pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutarate
0.55
malonyl-CoA
-
pH 7.8, 30°C, cosubstrate succinate
0.7
malonyl-CoA
-
pH 7.8, 30°C, cosubstrate methylmalonate
1.95
methylmalonate
-
pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutaryl-CoA, reverse reaction
2.2
methylmalonate
-
pH 7.8, 30°C, cosubstrate malonylCoA
2.44
methylmalonate
-
pH 7.8, 30°C, cosubstrate glutaryl-CoA
2.7
methylmalonate
-
pH 7.8, 30°C, cosubstrate succinyl-CoA
3.05
methylmalonate
-
pH 7.8, 30°C, cosubstrate adipyl-CoA
0.65
methylmalonyl-CoA
-
pH 7.8, 30°C, cosubstrate malonate
0.72
methylmalonyl-CoA
-
pH 7.8, 30°C, cosubstrate glutarate or adipate
0.74
methylmalonyl-CoA
-
pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutarate
0.87
methylmalonyl-CoA
-
pH 7.8, 30°C, cosubstrate succinate
0.5
succinate
-
pH 7.8, 30°C, cosubstrate glutarylCoA
0.68
succinate
-
pH 7.8, 30°C, cosubstrate malonylCoA
0.73
succinate
-
pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutaryl-CoA, reverse reaction
0.88
succinate
-
pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutaryl-CoA, reverse reaction
0.95
succinate
-
pH 7.8, 30°C, cosubstrate adipyl-CoA
1.2
succinate
-
pH 7.8, 30°C, cosubstrate methylmalonyl-CoA
0.15
succinyl-CoA
-
pH 7.8, 30°C, cosubstrate glutarate
0.22
succinyl-CoA
-
pH 8.5, 30°C, cosubstrate 3-hydroxy-3-methylglutarate
0.25
succinyl-CoA
-
pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutarate
0.26
succinyl-CoA
-
pH 7.8, 30°C, cosubstrate adipate
0.28
succinyl-CoA
-
pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutarate
0.83
succinyl-CoA
-
pH 7.8, 30°C, cosubstrate methylmalonate
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