Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 2.8.2.4 - estrone sulfotransferase and Organism(s) Homo sapiens

for references in articles please use BRENDA:EC2.8.2.4
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
     2 Transferases
         2.8 Transferring sulfur-containing groups
             2.8.2 Sulfotransferases
                2.8.2.4 estrone sulfotransferase
Specify your search results
Select one or more organisms in this record: ?
This record set is specific for:
Homo sapiens
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
hide
The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms
Synonyms
hsult1e1, oestrogen sulphotransferase, estrogen sulphotransferase, estrone sulfotransferase, sulfotransferase 1e1, oestrogen sulfotransferase, estrogen sult, estradiol sulfotransferase, rest-6, sult1e, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
3'-phosphoadenylyl sulfate-estrone 3-sulfotransferase
-
-
-
-
3'-phosphoadenylyl sulfate:oestrone sulfotransferase
-
-
-
-
cytosolic sulfotransferase
-
E2-inactivating estrogen sulfotransferase
-
-
ESFT
-
-
estrogen sulfotransferase
estrogen sulphotransferase
-
-
-
-
estrogen SULT
-
estrogen-ST
-
-
estrone sulfotransferase
-
-
oestrogen sulphotransferase
steroid sulfotransferase
sulfotransferase
-
-
sulfotransferase 1E1
-
-
SULT1A1
SULT1A12
-
-
SULT1A13
-
-
SULT1E1
additional information
-
SULT1E1 belongs tot he superfamily of cytosolic SULTs
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
3'-phosphoadenylyl sulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
sulfate group transfer
-
-
-
-
PATHWAY SOURCE
PATHWAYS
SYSTEMATIC NAME
IUBMB Comments
3'-phosphoadenylyl-sulfate:estrone 3-sulfotransferase
-
CAS REGISTRY NUMBER
COMMENTARY hide
9026-06-6
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
17beta-estradiol + 3'-phosphoadenylyl sulfate
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
show the reaction diagram
-
-
-
-
?
3'-phopshoadenylyl sulfate + resveratrol
adenosine 3',5'-bisphosphate + resveratrol 3-O-sulfate + resveratrol 4'-O-sulfate + resveratrol 3,4'-O-disulfate
show the reaction diagram
-
i.e. 3,5,4'-trihydroxystilbene, a phytoestrogen with mixed estrogen agonist/antagonist properties developed as a chemopreventive agent, interaction of resveratrol with 17beta-estradiol, overview
three different sulfate products, product identification by NMR, overview
-
?
3'-phosphoadenylyl sulfate + 1-naphthol
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
show the reaction diagram
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol sulfate
show the reaction diagram
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
3'-phosphoadenylyl sulfate + 2-methyl-17beta-estradiol
adenosine 3',5'-bisphosphate + 2-methyl-17beta-estradiol 3-sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + 3-cyano-7-hydroxycoumarin
adenosine 3',5'-bisphosphate + 3-cyano-7-hydroxycoumaryl sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + 3alpha-hydroxytibolone
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
3'-phosphoadenylyl sulfate + 3beta-hydroxytibolone
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
3'-phosphoadenylyl sulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
3'-phosphoadenylyl sulfate + 6-hydroxy-4-methylbenzo[d]thiazole-2-carbonitrile
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
i.e. proluciferin substrate UGT-Glo substrate A, GSA
-
-
?
3'-phosphoadenylyl sulfate + apigenin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + beta-estradiol
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
show the reaction diagram
3'-phosphoadenylyl sulfate + chrysin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + desipramine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + diethylstilbestrol
adenosine 3',5'-bisphosphate + diethylstilbestrol sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + epicatechin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
show the reaction diagram
3'-phosphoadenylyl sulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + estrogen
adenosine 3',5'-bisphosphate + estrogen 3-sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
show the reaction diagram
3'-phosphoadenylyl sulfate + ethinyl estradiol
adenosine 3',5'-bisphosphate + ethinyl estradiol 3-sulfate
show the reaction diagram
-
a synthetic oral contraceptive, low activity
-
-
?
3'-phosphoadenylyl sulfate + L-triiodothyronine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + quercetin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + resveratrol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + tamoxifen
adenosine 3',5'-bisphosphate + tamoxifen sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + testosterone
adenosine 3',5'-bisphosphate + testosterone sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + xanthurenic acid
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
?
3'-phosphoadenylylsulfate + 17alpha ethinyl estradiol
adenosine 3',5'-bisphosphate + 17alpha ethinyl estradiol 3-sulfate
show the reaction diagram
3'-phosphoadenylylsulfate + 17alpha-ethinylestradiol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
isoform SULT1A3
-
-
?
3'-phosphoadenylylsulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylylsulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
show the reaction diagram
3'-phosphoadenylylsulfate + 2-OH-1,3,7,8-tetrachlorinated dibenzo-p-dioxine
adenosine 3',5'-bisphosphate + 2-OH-1,3,7,8-tetrachlorinated dibenzo-p-dioxine sulfate
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + 2-OH-1,3,7,8-tetrachlorinated dibenzofuran
adenosine 3',5'-bisphosphate + 2-OH-1,3,7,8-tetrachlorinated dibenzofuranyl sulfate
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + 2-OH-3,7,8-trichlorinated dibenzo-p-dioxine
adenosine 3',5'-bisphosphate + 2-OH-3,7,8-trichlorinated dibenzo-p-dioxine sulfate
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + 2-OH-4,2',4'-trichlorodiphenyl ether
adenosine 3',5'-bisphosphate + 2-OH-4,2',4'-trichlorodiphenyl ethyl sulfate
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + 2-OH-4,5,3',2',3',4'-tetrachlorated biphenyl
adenosine 3',5'-bisphosphate + 2-OH-4,5,3',4'-tetrachlorated biphenyl sulfate
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + 2-OH-6,7,8-trichlorinated dibenzofuran
adenosine 3',5'-bisphosphate + 2-OH-6,7,8-trichlorinated dibenzofuranyl sulfate
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + 2-OH-7,8-dichlorinated dibenzo-p-dioxine
adenosine 3',5'-bisphosphate + 2-OH-7,8-dichlorinated dibenzo-p-dioxine sulfate
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + 2-OH-7,8-dichlorinated dibenzofuran
adenosine 3',5'-bisphosphate + 2-OH-7,8-dichlorinated dibenzofuranyl sulfate
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + 3,5,3',5'-tetrabromo-4,4'-isopropylidendiphenol
adenosine 3',5'-bisphosphate + 3,5,3',5'-tetrabromo-4,4'-isopropylidendiphenyl sulfate
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + 3,5,3',5'-tetrachloro-4,4'-isopropylidendiphenol
adenosine 3',5'-bisphosphate + 3,5,3',5'- tetrachloro-4,4'-isopropylidendiphenyl sulfate
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + 3-OH-2,4,7,8-tetrachlorinated dibenzofuran
adenosine 3',5'-bisphosphate + 3-OH-2,4,7,8-tetrachlorinated dibenzofuranyl sulfate
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + 3-OH-2,6,7,8,9-pentachlorinated dibenzofuran
adenosine 3',5'-bisphosphate + 3-OH-2,6,7,8,9-pentachlorinated dibenzofuranyl sulfate
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + 3-OH-2,6,7,8-tetrachlorinated dibenzofuran
adenosine 3',5'-bisphosphate + 3-OH-2,6,7,8-tetrachlorinated dibenzofuranyl sulfate
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + 3-OH-4,5,3',4'-tetrachlorated biphenyl
adenosine 3',5'-bisphosphate + 3-OH-4,5,3',4'-tetrachlorated biphenyl sulfate
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + 4,4'-(OH)2-3,5,3',5'-tetrachlorated biphenyl
adenosine 3',5'-bisphosphate + 4,4'-(OH)2-3,5,3',5'-tetrachlorated biphenyl sulfate
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + 4-hydroxy-2,3,5,3',4'-pentachlorobiphenyl
adenosine 3',5'-bisphosphate + 4-hydroxy-2,3,5,3',4'-pentachlorobiphenyl sulfate
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + 4-hydroxy-3,2',3',4',5'-pentachlorobiphenyl
adenosine 3',5'-bisphosphate + 4-hydroxy-3,2',3',4',5'-pentachlorobiphenyl sulfate
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + 4-OH-1,3,6,7-tetrachlorinated dibenzofuran
adenosine 3',5'-bisphosphate + 4-OH-1,3,6,7-tetrachlorinated dibenzofuranyl sulfate
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + 4-OH-2',4',6'-tribromodiphenyl ether
adenosine 3',5'-bisphosphate + 4-OH-2',4',6'-tribromodiphenyl ethyl sulfate
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + 4-OH-3',2',4',6'-tetrabromodiphenyl ether
adenosine 3',5'-bisphosphate + 4-OH-3',2',4',6'-tetrabromodiphenyl ethyl sulfate
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + 4-OH-3',5,2',4',6'-pentabromodiphenyl ether
adenosine 3',5'-bisphosphate + 4-OH-3',5,2',4',6'- pentabromodiphenyl ethyl sulfate
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + 4-OH-3,3',4'-trichlorated biphenyl
adenosine 3',5'-bisphosphate + 4-OH-3,3',4'-trichlorated biphenyl sulfate
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + butylated hydroxyanisole
adenosine 3',5'-bisphosphate + butylated hydroxyanisole sulfate
show the reaction diagram
-
-
r
3'-phosphoadenylylsulfate + catechin hydrate
adenosine 3',5'-bisphosphate + catechin hydrate sulfate
show the reaction diagram
-
-
r
3'-phosphoadenylylsulfate + daidzein
adenosine 3',5'-bisphosphate + daidzein sulfate
show the reaction diagram
-
-
r
3'-phosphoadenylylsulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
show the reaction diagram
3'-phosphoadenylylsulfate + dopamine
adenosine 3',5'-bisphosphate + dopamine sulfate
show the reaction diagram
3'-phosphoadenylylsulfate + epicatechin
adenosine 3',5'-bisphosphate + epicatechin sulfate
show the reaction diagram
-
-
r
3'-phosphoadenylylsulfate + epigallocatechin gallate
adenosine 3',5'-bisphosphate + epigallocatechin gallate sulfate
show the reaction diagram
-
-
r
3'-phosphoadenylylsulfate + estradiol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
show the reaction diagram
3'-phosphoadenylylsulfate + estriol
adenosine 3',5'-bisphosphate + estriol 3-sulfate
show the reaction diagram
3'-phosphoadenylylsulfate + estrogen
adenosine 3',5'-bisphosphate + estrogen sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
show the reaction diagram
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone sulfate
show the reaction diagram
3'-phosphoadenylylsulfate + genistein
adenosine 3',5'-bisphosphate + genistein 7-sulfate + genistein 4'-sulfate
show the reaction diagram
-
-
r
3'-phosphoadenylylsulfate + kaempferol
adenosine 3',5'-bisphosphate + kaempferol sulfate
show the reaction diagram
-
-
r
3'-phosphoadenylylsulfate + myricetin
adenosine 3',5'-bisphosphate + myricetin sulfate
show the reaction diagram
-
-
r
3'-phosphoadenylylsulfate + n-propyl gallate
adenosine 3',5'-bisphosphate + n-propyl gallate sulfate
show the reaction diagram
-
-
r
3'-phosphoadenylylsulfate + p-nitrophenol
adenosine 3',5'-bisphosphate + p-nitrophenyl sulfate
show the reaction diagram
3'-phosphoadenylylsulfate + pregnenolone
adenosine 3',5'-bisphosphate + pregnenolone 3-sulfate
show the reaction diagram
3'-phosphoadenylylsulfate + quercetin
adenosine 3',5'-bisphosphate + quercetin sulfate
show the reaction diagram
3'-phosphoadenylylsulfate + resveratrol
adenosine 3',5'-bisphosphate + resveratrol sulfate
show the reaction diagram
-
-
-
r
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
3'-phosphoadenylyl sulfate + 1-naphthol
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
show the reaction diagram
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol sulfate
show the reaction diagram
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
3'-phosphoadenylyl sulfate + 2-methyl-17beta-estradiol
adenosine 3',5'-bisphosphate + 2-methyl-17beta-estradiol 3-sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + 3alpha-hydroxytibolone
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
sulfation inactivates the hydroxylated metabolite of tibolone, a synthetic steroid used for the treatment for climacteric symptoms and postmenopausal osteoporosis
-
-
?
3'-phosphoadenylyl sulfate + 3beta-hydroxytibolone
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
sulfation inactivates the hydroxylated metabolite of tibolone, a synthetic steroid used for the treatment for climacteric symptoms and postmenopausal osteoporosis
-
-
?
3'-phosphoadenylyl sulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + beta-estradiol
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + desipramine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + diethylstilbestrol
adenosine 3',5'-bisphosphate + diethylstilbestrol sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
show the reaction diagram
3'-phosphoadenylyl sulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + estrogen
adenosine 3',5'-bisphosphate + estrogen 3-sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
show the reaction diagram
3'-phosphoadenylyl sulfate + L-triiodothyronine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + tamoxifen
adenosine 3',5'-bisphosphate + tamoxifen sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + testosterone
adenosine 3',5'-bisphosphate + testosterone sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + xanthurenic acid
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
?
3'-phosphoadenylylsulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylylsulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
show the reaction diagram
3'-phosphoadenylylsulfate + estrogen
adenosine 3',5'-bisphosphate + estrogen sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
show the reaction diagram
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone sulfate
show the reaction diagram
additional information
?
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
NaCl
activates
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(+)-6beta-hydroxy-15,16-epoxylabda-8,13(16),14-trien-7-one
-
(+)-hispanone
-
(-)-6,9:15,16-diepoxy-9alpha-hydroxy-8,9-seco-13(16),14-labdadiene-7-one
-
16alpha-hydroxyestrone
-
maximum inhibition at 100 nM
17beta-estradiol
2,2',3',4,4',5,5'-heptachloro[1,1'-biphenyl]-3-ol
-
-
2,2',5,5'-tetrachloro-4-hydroxybiphenyl
-
-
2,3',4-trichloro-4'-hydroxybiphenyl
the inhibitor has been identified as a metabolite in human plasma with an estimated half-life of 6.5 years
-
2,4'-dichloro-4-hydroxybiphenyl
-
-
2,4,6-tribromophenol
-
-
2,4,6-Trichlorophenol
-
-
2,4,6-triiodophenol
-
-
2,6-Dichloro-4-nitrophenol
2-hydroxy-1,3,7,8-tetrachlorodibenzo-p-dioxin
-
-
2-hydroxy-3,4,2',3',4'-pentachlorobiphenyl
-
-
2-hydroxy-3,4,3',4'-tetrachlorobiphenyl
-
-
2-hydroxy-4,5,3',4'-tetrachlorobiphenyl
-
-
2-hydroxy-7,8-dichlorodibenzo-p-dioxin
-
-
2-hydroxy-7,8-dichlorodibenzofuran
-
-
2-OH-3,2'-dibromobiphenyl
-
-
3',4',7-trihydroxyisoflavone
-
-
3'-phosphoadenylylsulfate
-
-
3,3',5,5'-tetrachlorobisphenol A
-
-
3,3'-(hydroxy)2-4,4'-dichlorobiphenyl
-
-
3,3'-dichloro-4-hydroxybiphenyl
-
-
3,5-dibromo-4-hydroxy-benzoic acid (6-chloro-4-oxo-4H-chromen-3-ylmethylene)-hydrazide
DBHM
3,5-dibromo-4-hydroxybenzoic acid (6,8-dichloro-4-oxo-4H-chromen-3-ylmethylene) hydrazide
DBHD
3-hydroxy-2,4,5,3',4'-pentachlorobiphenyl
-
-
3-hydroxy-2,4,7,8,9-pentachlorodibenzofuran
-
-
3-hydroxy-2,4,7,8-tetrachlorodibenzofuran
-
-
3-hydroxy-4,5,2',3',4'-pentachlorobiphenyl
-
-
3-hydroxy-4,5,3',4',5'-pentachlorobiphenyl
-
-
3-hydroxy-4,5,3',4'-tetrachlorobiphenyl
-
-
3-OH-2,2'-dibromobiphenyl
-
-
3-OH-4,4'-dibromobiphenyl
-
-
3alpha-tibolone
-
activates SULT1E1 in MCF-7 cells by 50% and 37% at low concentrations of 50 nM and 500 nM, respectively, inhibits at 0.05 mM by 63%
3beta-tibolone
-
activates SULT1E1 in MCF-7 cells by 101% and 74% at low concentrations of 50 nM and 500 nM, respectively, inhibits at 0.05 mM by 54%
4,4'-(hydroxy)2-3,5,'3',5'-tetrachlorobiphenyl
-
-
4,4'-isopropyl idenediphenol-3,3',5,5'-tetrachlorobisphenol
-
-
4,4'-isopropylidenediphenol
-
-
4-chloro-4'-hydroxybiphenyl
-
-
4-ene tibolone
-
inhibits at high concentrations of 0.05 mM by 59%
4-hydroxy-2',3',4',5'-tetrachlorobiphenyl
-
-
4-hydroxy-2',4',6'-trichlorobiphenyl
-
-
4-hydroxy-2,2',3',4',5'-pentachlorobiphenyl
-
-
4-hydroxy-2,2',3',4',6'-pentachlorobiphenyl
-
-
4-hydroxy-2,2',3',5',6'-pentachlorobiphenyl
-
-
4-hydroxy-2,2',4',6'-tetrachlorobiphenyl
-
-
4-hydroxy-2,3,4,5,6-pentabromodiphenylether
-
-
4-hydroxy-2,3,5,2',3',4',5'-heptachlorobiphenyl
-
-
4-hydroxy-2,3,5,2',3',4'-hexachlorobiphenyl
-
-
4-hydroxy-2,3,5,2',4',5'-hexachlorobiphenyl
-
-
4-hydroxy-2,3,5,3',4'-pentachlorobiphenyl
-
-
4-hydroxy-2,3,5,6,2',4',5'-heptachlorobiphenyl
-
-
4-hydroxy-3,2',3',4',5'-pentachlorobiphenyl
-
-
4-hydroxy-3,2',3',4',6'-pentachlorobiphenyl
-
-
4-hydroxy-3,2',3',5',6'-pentachlorobiphenyl
-
-
4-hydroxy-3,2',4',6'-tetrachlorobiphenyl
-
-
4-hydroxy-3,3',4'-trichlorobiphenyl
-
-
4-hydroxy-3,5,2',3',4',5'-hexachlorobiphenyl
-
-
4-hydroxy-3,5,2',3',4'-pentachlorobiphenyl
-
-
4-hydroxy-3,5,3',4',5'-pentachlorobiphenyl
-
-
4-hydroxy-3,5,3',4'-tetrachlorobiphenyl
-
-
4-hydroxy-3,5,3',5'-tetrachlorobiphenyl
-
-
4-hydroxybenzoate esters
-
i.e.parabens, structure-activity relationship, overview
4-hydroxybenzoic acid
-
-
4-OH-2,2'-dibromobiphenyl
-
-
4-OH-3,4'-dibromobiphenyl
-
-
4-OH-4'-monobromobiphenyl
-
-
5,7-dichlorokynurenic acid
-
6-OH-2,2'-dibromobiphenyl
-
-
abiraterone
antiandrogen drug, metabolite abiraterone, not the parent drug abiraterone acetate, is responsible for the inhibition
Acetylsalicylate
binds near enough to the substrate site to prevent catalysis but not affect dissociation of the substrate-enzyme complex
adenosine 5'-(beta,gamma-imido) triphosphate
i.e. AMP-PNP, a non-hydrolysable ATP analogue
buthionine sulfoxamine
-
a GSH depletor, decreases SULT1E1 activity, but fails to affect the enzyme amount in Hep-G2 cells
butylparaben
-
50% inhibition at 0.021 mM, complete inhibition at 1 mM; strong inhibition, which is threefold higher in vivo than in vitro
chloroform
-
excess chloroform inactivates
cyproterone acetate
-
daidzein
-
-
daidzein 4,7-bissulfate
-
IC50: 0.01 mM
diclofenac
-
-
equol
-
potent mixed type inhibitor
ethylparaben
-
50% inhibition at 0.080 mM
formononetin
-
-
galeterone
antiandrogen drug
gavestinel
i.e. 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl]-1H-indole-2-carboxylic acid sodium salt
genistein
-
potent mixed type inhibitor
GSSG
-
oxidized glutathione, inactivation and kinetics, adenosine 3'-phosphate 5'-phosphosulfate protects
hydroxylated polychlorated biphenyls
-
-
-
Ibuprofen
-
ICI 182,720
-
produces a marked decrease (over 50%) of EST activity with respect to untreated control cell cultures at 24 h
indomethacin
-
Kynurenic acid
-
L689,560
i.e. trans-2-carboxy-5,7-dichloro-4-phenylaminocarboxylamino-1,2,3,4-tetrahydroquinoline
L701,324
i.e. 7-chloro-4-hydroxy-3(3-phenoxy)phenyl-2(H)-quinolinone
leosibiric acid A
most potent inhibition
leosibiric acid B
-
meclofenamate
binds near enough to the substrate site to prevent catalysis but not affect dissociation of the substrate-enzyme complex
Meclofenamic acid
-
medrogestone
-
biphasic effect, inhibits at high concentrations, but stimulates at low concentrations, overview
Mefenamic acid
methylparaben
-
50% inhibition at 0.330 mM
nimesulide
binds near enough to the substrate site to prevent catalysis but not affect dissociation of the substrate-enzyme complex
OrgOD14
-
active substance in Livial (r), above 0.05 mM decreases significantly biosynthesis of estrone by 50-60%, no effect in MDA-MB-231 cells
Pentachlorophenol
-
-
piroxicam
-
Promegestone
-
activates SULT1E1 by 26% at low concentrations of 500 nM, inhibits at 0.05 mM by 41%, leads to increased and decreased expression levels, respetively; biphasic effect, inhibits at high concentrations, but stimulates at low concentrations, overview
propylparaben
-
50% inhibition at 0.030 mM
pyridoxal 5'-phosphate
a competitive inhibitor for sulfotransferases
quercetin
resveratrol
salicylate
-
salicylic acid
-
-
spironolactone
-
tamoxifen
-
weak inhibition
tibolone
-
activates SULT1E1 in MCF-7 cells by 63% and 44% at low concentrations of 50 nM and 500 nM, respectively, inhibits at 0.05 mM by 64%
trans-resveratrol
-
0.1 mM resveratrol significantly decreases the SULT1E1-mediated beta-estradiol sulfation
triclosan
-
additional information
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
17-hydroxy-19-nor-7-methyl-17-pregn-5(10)-en-20-yn-3-one
3alpha-hydroxy-tibolone
-
biphasic effect, inhibits at high concentrations, but stimulates at low concentrations, in MCF-7 and T4-7D cells, overview
3alpha-tibolone
-
activates SULT1E1 in MCF-7 cells by 50% and 37% at low concentrations of 50 nM and 500 nM, respectively, inhibits at 0.05 mM by 63%
3beta-hydroxy-tibolone
-
biphasic effect, inhibits at high concentrations, but stimulates at low concentrations, in MCF-7 and T4-7D cells, overview
3beta-hydroxytibolone
-
102% stimulation of activity at 0.0005 mM
3beta-tibolone
-
activates SULT1E1 in MCF-7 cells by 101% and 74% at low concentrations of 50 nM and 500 nM, respectively, inhibits at 0.05 mM by 54%
4-ene-tibolone
-
-
celecoxib
-
-
medrogestone
Melatonin
-
the level of EST mRNA steady-state of cells treated with melatonin is three times higher than that in control cells
N-acetylcysteine
-
a GSH inducer, increases SULT1E1 activity, but fails to affect the enzyme amount in Hep-G2 cells
NaCl
-
activity of liver EST transiently expressed in COS-1 cells increases 86% in presence of 150 mM
nomegestrol acetate
progesterone
-
specific induction by 0.01 mM, 7fold increase in sulfation of beta-estradiol, Ishikawa endometrial adenocarcinoma cells
Promegestone
quercetin
-
-
resveratrol
-
-
tibolone
additional information
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.000005 - 0.0082
17beta-estradiol
0.000005
3'-phosphoadenylyl sulfate
-
pH and temperature not specified in the publication
0.000059 - 0.01318
3'-phosphoadenylylsulfate
0.00018
3alpha-tibolone
pH 6.5, 37°C, recombinant SULT1E1
0.00048
3beta-tibolone
pH 6.5, 37°C, recombinant SULT1E1
0.15
4-nitrophenol
-
pH 6.1, 25°C
0.000038
adenosine 3',5'-bisphosphate
-
pH 6.3, 37°C
0.0053
apigenin
0.00033
beta-estradiol
isoform SULT1E1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
0.0045
chrysin
0.00005 - 0.0607
dehydroepiandrosterone
0.2407 - 79.35
dopamine
0.962
epicatechin
0.000004 - 0.0000105
estradiol
0.0001 - 0.0166
estrone
0.000007
ethinyl estradiol
-
pH 7.4, SULT1E1
0.0766 - 0.9372
p-nitrophenol
0.00032 - 0.002
quercetin
0.00058 - 0.0069
resveratrol
additional information
additional information
-
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00267 - 0.0217
17beta-estradiol
0.52
4-nitrophenol
-
pH 6.1, 25°C
kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00011 - 0.694
3-cyano-7-hydroxycoumarin
0.0009 - 0.151
4-nitrophenol
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.000013 - 0.00008
17beta-estradiol
0.00006
2-hydroxy-1,3,7,8-tetrachlorodibenzo-p-dioxin
-
pH 7.2, 37°C
0.000002
2-hydroxy-7,8-dichlorodibenzo-p-dioxin
-
pH 7.2, 37°C
0.00027
2-hydroxy-7,8-dichlorodibenzofuran
-
pH 7.2, 37°C
0.002
3',4',7-trihydroxyisoflavone
-
-
0.000155
3'-phosphoadenylylsulfate
-
pH 6.3, 37°C
0.000035
3,3',5,5'-tetrachlorobisphenol A
-
pH 7.2, 37°C
0.00000615
3-hydroxy-2,4,7,8,9-pentachlorodibenzofuran
-
pH 7.2, 37°C
0.014
4,4'-isopropylidenediphenol
-
pH 7.2, 37°C
0.00015
4-hydroxy-2,3,4,5,6-pentabromodiphenylether
-
pH 7.2, 37°C
0.002
daidzein
-
-
0.0004
equol
-
-
0.006
formononetin
-
-
0.0005
genistein
-
-
0.00058
quercetin
-
pH 7.4, 37°C
0.00036 - 0.0023
resveratrol
additional information
additional information
-
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0313
(+)-6beta-hydroxy-15,16-epoxylabda-8,13(16),14-trien-7-one
Homo sapiens
at pH 6.0 and 37°C
0.0198
(+)-hispanone
Homo sapiens
at pH 6.0 and 37°C
0.0405
(-)-6,9:15,16-diepoxy-9alpha-hydroxy-8,9-seco-13(16),14-labdadiene-7-one
Homo sapiens
at pH 6.0 and 37°C
0.000019
2,2',5,5'-tetrachloro-4-hydroxybiphenyl
Homo sapiens
recombinant SULT1E1, pH 7.4, 37°C
-
0.00044
2,3',4-trichloro-4'-biphenylsulfate
Homo sapiens
recombinant SULT1E1, pH 7.4, 37°C
-
0.0000073
2,3',4-trichloro-4'-hydroxybiphenyl
Homo sapiens
recombinant SULT1E1, pH 7.4, 37°C
-
0.000018
2,4'-dichloro-4-hydroxybiphenyl
Homo sapiens
recombinant SULT1E1, pH 7.4, 37°C
-
0.0000072
3,3'-dichloro-4-hydroxybiphenyl
Homo sapiens
recombinant SULT1E1, pH 7.4, 37°C
-
0.0013
4-chloro-4'-hydroxybiphenyl
Homo sapiens
recombinant SULT1E1, pH 7.4, 37°C
-
1.5
Acetylsalicylate
Homo sapiens
pH 6.5, 37°C, versus beta-estradiol
0.012 - 0.062
butylparaben
0.01
daidzein 4,7-bissulfate
Homo sapiens
-
IC50: 0.01 mM
0.14
Ibuprofen
Homo sapiens
pH 6.5, 37°C, versus beta-estradiol
0.0079
leosibiric acid A
Homo sapiens
at pH 6.0 and 37°C
0.0232
leosibiric acid B
Homo sapiens
at pH 6.0 and 37°C
0.0065
meclofenamate
Homo sapiens
pH 6.5, 37°C, versus beta-estradiol
0.0054
Meclofenamic acid
Homo sapiens
at pH 6.0 and 37°C
0.19
naproxen
Homo sapiens
pH 6.5, 37°C, versus beta-estradiol
0.23
nimesulide
Homo sapiens
pH 6.5, 37°C, versus beta-estradiol
0.27 - 9.4
piroxicam
0.91
salicylic acid
Homo sapiens
pH 6.5, 37°C, versus beta-estradiol
0.038
sulindac
Homo sapiens
pH 6.5, 37°C, versus beta-estradiol
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.00000000005
-
NHEK cell enzyme, cytosol, substrate beta-estradiol
0.0000000001
-
skin enzyme, cytosol, substrate estrone
0.0000000008
-
skin enzyme, cytosol, substrate dehydroepiandrosterone
0.0000000011
-
skin enzyme, cytosol, substrate beta-estradiol
0.0000000049
-
recombinant SULT1E1
0.0000000185
-
liver enzyme, cytosol, substrate beta-estradiol
0.000158
catechin hydrate as substrate
0.000171
daidzein as substrate
0.000193
genistein as substrate
0.000343
epigallocatechin gallate as substrate
0.000351
epicatechin as substrate
0.000393
butylated hydroxyanisole as substrate
0.000452
kaempferol as substrate
0.000505
17alpha-ethynylestradiol as substrate
0.000526
estrone as substrate
0.000594
myricetin as substrate
0.000597
n-propyl gallate as substrate
0.00061
quercetin as substrate
0.012
-
purified recombinant SULT1E1 with substrate estrone
0.0455
-
purified recombinant SULT1E1 with substrate 17beta-estradiol
additional information
-
activity in healthy and hyperplasic endometrium with or without polycystic ovary syndrome, overview
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6.2
-
assay at
7
-
assay at
7.5
assay at
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
25
-
assay at
pI VALUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5.8
-
placental enzyme, isoelectrofocusing
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
Ishikawa endometrial adenocarcinoma
Manually annotated by BRENDA team
-
fetal, isoform SULT1E1
Manually annotated by BRENDA team
-
female aortic smooth muscle cell line CRL-1999 cell
Manually annotated by BRENDA team
-
benign, and primary and secondary malignant bone tumors, from patients undergoing routine surgery for skeletal tumors
Manually annotated by BRENDA team
-
stromal cells
Manually annotated by BRENDA team
-
specific expression of SULT1E1
Manually annotated by BRENDA team
-
recombinant SULT1E1 expressed in insect Sf9 cells
Manually annotated by BRENDA team
determination of the levels of SULT1E1, STS and estrogen receptor alpha (ERalpha) protein in paraffin-embedded specimens from 206 patients with Federation of Gynecology and Obstetrics stage II-IV EOC treated with debulking surgery and standard platinum-based adjuvant chemotherapy. Significantly higher SULT1E1 levels are observed in better differentiated EOC tumors compared to grade 3 EOC tumors. STS and SULT1E1 levels are positively associated with ERalpha abundance
Manually annotated by BRENDA team
-
from from 14 patients operated for symptomatic cholelithiais
Manually annotated by BRENDA team
-
an osteosarcoma cell line, increased expression compared to healthy cells
Manually annotated by BRENDA team
-
epidermal
Manually annotated by BRENDA team
-
fetal and adult, isoform SULT1E1
Manually annotated by BRENDA team
-
estrogen sulfotransferase is significantly more active in the normal breast cell than in the cancer cell
Manually annotated by BRENDA team
-
an osteosarcoma cell line, high SULT1E1 expression level
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
-
intratumoral stromal cell
Manually annotated by BRENDA team
-
hormone-dependent breast cancer cell line
Manually annotated by BRENDA team
-
a Ewing’s sarcoma cell line, expression level of SULT1E1 is slightly reduced comapred to heathy cells
Manually annotated by BRENDA team
additional information
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
the estrogen sulfotransferase (EST or SULT1E1) is a member of the sulfotransferase family. It shares high amino acid homology with other sulfotransferase isoforms. But EST is believed to have unique functions due to its distinct substrates and specific tissue distribution and sex-regulated expression. The effect of EST on adipogenesis seems to be species specific. The anti-adipogenic activity of EST in mice is opposite to the pro-adipogenic effect of the same enzyme in human adipocytes
malfunction
metabolism
physiological function
additional information
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
ST1E1_HUMAN
294
0
35126
Swiss-Prot
other Location (Reliability: 1)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
34200
-
calculated from cDNA
35000
35120
-
calculated from amino acid sequence
35123
-
2 * 35123, cDNA calculation
36000
-
SDS-PAGE
62000
-
gel filtration
68000
-
SDS-PAGE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 35000, SDS-PAGE
dimer
additional information
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D65N/K85E/E86K/F138Y
the mutant exhibits increased thermostability (heat inactivation at 43.4°C) compared to the wild type enzyme (42°C)
E12G/N29D/D65N/C83R/N87D/M98V/F138Y/G182S/L195M/H224K
the mutant exhibits increased thermostability (heat inactivation at 43.1°C) compared to the wild type enzyme (42°C)
E12G/N29D/F138Y/G182S/L251V
the mutant exhibits increased thermostability (heat inactivation at 51.8°C) compared to the wild type enzyme (42°C)
E12G/N29D/V73A/N87D/F138Y/G182S/L195M/E211G/E285G
the mutant exhibits increased thermostability (heat inactivation at 52.1°C) compared to the wild type enzyme (42°C)
F138Y/G182S/H224K/E285G
the mutant exhibits increased thermostability (heat inactivation at 54.6°C) compared to the wild type enzyme (42°C)
F138Y/G182S/L195M/E211G
the mutant exhibits increased thermostability (heat inactivation at 55.8°C) compared to the wild type enzyme (42°C)
H107A
-
site-directed mutagenesis, humSULT1E1, presence of a histidine residue at position 107 is essential for the production of a functional protein, substitution of this amino acid to alanine results in complete loss of activity towards all substrates tested
H224Q
-
naturally ocuring mutation in SULT1E1, genotyping in Jewish women of the Ashkenazi ethnic origin
K85A
-
site-directed mutagenesis, humSULT1E1
K85E/A135T/F138Y/G182S/L251V
the mutant exhibits increased thermostability (heat inactivation at 46.3°C) compared to the wild type enzyme (42°C)
N29D/L195M/H224K/L251V
the mutant exhibits increased thermostability (heat inactivation at 48.3°C) compared to the wild type enzyme (42°C)
V145E
-
site-directed mutagenesis, humSULT1E1
V307I
polymorphism of SULT1E1
V73A/N87D/G182S/H224K/L251V/E285G
the mutant exhibits increased thermostability (heat inactivation at 52.8°C) compared to the wild type enzyme (42°C)
additional information
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
25
-
half-life 2 h, glycerol prevents detectable deterioration of activity over 3 h
30 - 45
-
thermal inactivation at 45°C
42
the wild type enzyme is inactivated at 42°C
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-70°C, liver cytosol, 50 mM Tris-HCl, pH 7.8, 0.25 M sucrose, 0.5 mM EDTA, 0.1 mM DTT, and 0.02 mM BHT, no loss of activity during storage
-70°C, stable for several days
-
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
Ni-NTA agarose column chromatography
Ni-NTA resin column chromatography, and gel filtration
recombinant enzyme
-
recombinant enzyme from Escherichia coli strain BL21(DE3)
recombinant SULT1E1
-
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
EST cDNA cloned and expressed in COS-1 cells
-
EST cDNA subcloned into pKK233-2 and expressed in Escherichia coli XL1-Blue
-
EST cloned and expressed in Escherichia coli K1
-
EST expression analysis in healthy and endometriosis uterine endometrium showing no significant differences
-
EST expression analysis in presence and absence of melatonin
-
EST expression and regulation in invasive breast cancer and ductal carcinoma in situ, overview
-
expressed in Escherichia coli BL21(DE3) cells
expression analysis of EST by real-time RT-PCR in prostate cancer cell lines, overview
-
expression analysis of SULT1E1 in gallbladder tissue
-
expression analysis of the enzyme in healthy and preinvasive and invasive tumor breast tissue
-
expression of GFP-tagged SULT1E1 in HEK-293 cell cytoplasm, subcellular localization study, RT-PCR expression analysis, overview
expression of GFP-tagged SULT1E1 in HEK-293 cells, localization in the cytoplasm
expression of SULT1E1 in prostate cancer CAHPV-10 cells leading to changes in the transcriptional expression of selected signal transduction-related genes, real-time RT-PCR expression analysis, overview
-
functional overexpression of SULT1E1 in Escherichia coli strain XL-1 blue cytosol
gene SULT1E1, localized to chromosome 4 (4q13.2), different transcripts and genetic variants, overview
hEST cloned and expressed in Salmonella typhimurium
-
human placental cDNA library constructed in lambda gt11, expression vector encoding estrogen sulfotransferase transfected in human adrenal adenocarcinoma SW-13 cells
-
recombinant expression of the enzyme in Escherichia coli strain BL21(DE3)
stable expression of SULT1E1 in MCF-7 cells, expression of His-tagged SULT1E1 using a baculoviral-Spodoptera frugiperda Sf9 cell system
SULT1E1 cloned and expressed in Escherichia coli BL21 (DE3)
SULT1E1 expression analysis
-
SULT1E1 expression in a prokaryotic expression system
-
SULT1E1, DNA and mino acid sequence determination and analysis, genotyping
-
SULT1E1, quantitative expression analysis in benign and in primary and secondary malignant bone tumors
-
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
a confirmed repressor of EST gene in human primary hepatocytes and hepatocellular carcinoma Huh7 cells is pregnane X receptor (PXR), when the PXR is activated by rifampicin. Aryl hydrocarbon receptor (AhR) activation has also been shown to suppress EST expression
enzyme activity is significantly higher in the endometrial carcinoma than in normal endometrial tissues
-
factors HNF4alpha and Nrf2 induce the expression of enzyme SULT1E1. Factor HNF4alpha is induced by oxidative stress, and factor Nrf2 is induced by estradiol via the P13K/GSK3B pathway
hepatic EST is also positively regulated by the liver X receptor (LXR). The induction of EST in acute inflammation in sepsis model is nuclear factor kappa-B (NF-kappaB) dependent, and EST is an NF-kappaB target gene. Inflammation and oxidative stress induce the activation of nuclear factor 2 (Nrf2), followed by the induction of EST who is a direct transcriptional target of Nrf2
in liver SULT1E1 is repressed by xenobiotic activators of the pregnane X receptor and aryl hydrocarbon receptor peroxisome proliferator
inhibition of cystic fibrosis transmembrane receptor expression in MMNK-1 cells results in the induction SULT1E1 message and activity in Hep-G2 cells
-
insulin-like growth factor-1 increases SULT1E1 mRNA and SULT1E1 protein levels
reduced SULT1E1 expression is observed in the eutopic endometrium relative to the superficial lesions as well as during the follicular phase of the menstrual cycle
SULT expression in breast cancer cells can be stimulated by promegestone, SULT1E1 expression can be controlled by progesterone during the menstrual cycle and during early pregnancy
-
SULT1E1 is epigenetically regulated, as its expression is induced by the histone deacetylase inhibitor trichostatin A in MCF10A cells. In endometrial cancer cell line Ishikawa SULT1E1 is induced by steroid drug tibolone via progesterone receptor. In liver, it is activated via peroxisome proliferator activated receptor alpha and the liver X receptor
the enzyme expression is downregulated in ovarian cancer
the enzyme expression is low in preadipocytes but increases upon differentiation
the increase in SULT1E1 activity results in the alteration of estradiol-regulated protein expression in cystic fibrosis liver, SULT1E1 expression in HepG2 cells is inducible by sterol mediated liver-X-receptor activation although not by progestins that induce SULT1E1 in the endometrium
-
there are significantly higher mRNA levels in ectopic endometrium of deep infiltrating endometriosis, when compared to the normal endometrium. The enzyme expression is upregulated in endometrial cancer
WY14643 decreases SULT1E1 mRNA and SULT1E1 protein levels
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
analysis
medicine
pharmacology
-
reactivation of endogenous SULT1E1 gene expression may represent a novel therapeutic strategy to inhibit estrogen-dependent growth of breast cancer cells
synthesis
generation of a complete set of recombinant fission yeast strains each expressing one of the 14 human SULT enzymes. The intracellular production of the cofactor 3'-phosphoadenosine 5'-phosphosulfate (PAPS) necessary for SULT activity is sufficiently high to support metabolite production
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Forbes-Bamforth, K.J.; Coughtrie, M.W.H.
Identification of a new adult human liver sulfotransferase with specificity for endogenous and xenobiotic estrogens
Biochem. Biophys. Res. Commun.
198
707-711
1994
Homo sapiens
Manually annotated by BRENDA team
Chetrite, G.; Pasqualini, J.R.
Steroid sulphotransferase and 17beta-hydroxysteroid dehydrogenase activities in Ishikawa human endometrial adenocarcinoma cells
J. Steroid Biochem. Mol. Biol.
61
27-34
1997
Homo sapiens
Manually annotated by BRENDA team
Nakamura, Y.; Miki, Y.; Suzuki, T.; Nakata, T.; Darnel, A.D.; Moriya, T.; Tazawa, C.; Saito, H.; Ishibashi, T.; Takahashi, S.; Yamada, S.; Sasano, H.
Steroid sulfatase and estrogen sulfotransferase in the atherosclerotic human aorta
Am. J. Pathol.
163
1329-1339
2003
Homo sapiens
Manually annotated by BRENDA team
Tseng, L.; Lee, L.Y.; Mazella, J.
Estrogen sulfotransferase in human placenta
J. Steroid Biochem.
22
611-615
1985
Homo sapiens
Manually annotated by BRENDA team
Hondoh, T.; Suzuki, T.; Hirato, K.; Saitoh, H.; Kadofuku, T.; Sato, T.; Yanahara, T.
Purification and properties of estrogen sulfotransferase of human fetal liver
Biomed. Res.
14
129-136
1993
Homo sapiens
-
Manually annotated by BRENDA team
Aksoy, I.A.; Wood, T.C.; Weinshilboum, R.
Human liver estrogen sulfotransferase: identification by cDNA cloning and expression
Biochem. Biophys. Res. Commun.
200
1621-1629
1994
Homo sapiens
Manually annotated by BRENDA team
Bernier, F.; Lopez, S.I.; Labrie, F.; van Luu, T.
Cloning and expression of cDNA encoding human placental estrogen sulfotransferase
Mol. Cell. Endocrinol.
99
R11-R15
1994
Homo sapiens
Manually annotated by BRENDA team
Falany, J.L.; Falany, C.N.
Regulation of estrogen sulfotransferase in human endometrial adenocarcinoma cells by progesterone
Endocrinology
137
1395-1401
1996
Homo sapiens
Manually annotated by BRENDA team
Her, C.; Szumlanski, C.; Aksoy, I.A.; Weinshilboum, R.M.
Human jejunal estrogen sulfotransferase and dehydroepiandrosterone sulfotransferase: immunochemical characterization of individual variation
Drug Metab. Dispos.
24
1328-1335
1996
Homo sapiens
Manually annotated by BRENDA team
Kakuta, Y.; Petrotchenko, E.V.; Pedersen, L.C.; Negishi, M.
The sulfuryl transfer mechanism. Crystal structure of a vanadate complex of estrogen sulfotransferase and mutational analysis
J. Biol. Chem.
273
27325-27330
1998
Homo sapiens
Manually annotated by BRENDA team
Zhang, H.; Varlamova, O.; Vargas, F.M.; Falany, C.N.; Leyh, T.S.; Varmalova, O.
Sulfuryl transfer: the catalytic mechanism of human estrogen sulfotransferase
J. Biol. Chem.
273
10888-10892
1998
Homo sapiens
Manually annotated by BRENDA team
Chetrite, G.S.; Kloosterboer, H.J.; Philippe, J.C.; Pasqualini, J.R.
Effect of Org OD14 (LIVIAL) and its metabolites on human estrogen sulphotransferase activity in the hormone-dependent MCF-7 and T-47D, and the hormone-independent MDA-MB-231, breast cancer cell lines
Anticancer Res.
19
269-275
1999
Homo sapiens
Manually annotated by BRENDA team
Pasqualini, J.R.; Chetrite, G.S.
Estrone sulfatase versus estrone sulfotransferase in human breast cancer: potential clinical applications
J. Steroid Biochem. Mol. Biol.
69
287-292
1999
Homo sapiens
Manually annotated by BRENDA team
Qian, Y.; Song, W.C.
Correlation between PAP-dependent steroid binding activity and substrate specificity of mouse and human estrogen sulfotransferases
J. Steroid Biochem. Mol. Biol.
71
123-131
1999
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Hempel, N.; Barnett, A.C.; Bolton-Grob, R.M.; Liyou, N.E.; McManus, M.E.
Site-directed mutagenesis of the substrate-binding cleft of human estrogen sulfotransferase
Biochem. Biophys. Res. Commun.
276
224-230
2000
Homo sapiens
Manually annotated by BRENDA team
Kester, M.H.; Bulduk, S.; Tibboel, D.; Meinl, W.; Glatt, H.; Falany, C.N.; Coughtrie, M.W.; Bergman, A.; Safe, S.H.; Kuiper, G.G.; Schuur, A.G.; Brouwer, A.; Visser, T.J.
Potent inhibition of estrogen sulfotransferase by hydroxylated PCB metabolites: a novel pathway explaining the estrogenic activity of PCBs
Endocrinology
141
1897-1900
2000
Homo sapiens
Manually annotated by BRENDA team
Otake, Y.; Nolan, A.L.; Walle, U.K.; Walle, T.
Quercetin and resveratrol potently reduce estrogen sulfotransferase activity in normal human mammary epithelial cells
J. Steroid Biochem. Mol. Biol.
73
265-270
2000
Homo sapiens
Manually annotated by BRENDA team
Pai, T.G.; Suiko, M.; Sakakibara, Y.; Liu, M.C.
Sulfation of Flavonoids and Other Phenolic Dietary Compounds by the Human Cytosolic Sulfotransferases
Biochem. Biophys. Res. Commun.
285
1175-1179
2001
Homo sapiens (P49888)
Manually annotated by BRENDA team
Song, W.C.
Biochemistry and reproductive endocrinology of estrogen sulfotransferase
Ann. N. Y. Acad. Sci.
948
43-50
2001
Bos taurus, Cavia porcellus, Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Kester, M.H.; Bulduk, S.; van Toor, H.; Tibboel, D.; Meinl, W.; Glatt, H.; Falany, C.N.; Coughtrie, M.W.; Schuur, A.G.; Brouwer, A.; Visser, T.J.
Potent inhibition of estrogen sulfotransferase by hydroxylated metabolites of polyhalogenated aromatic hydrocarbons reveals alternative mechanism for estrogenic activity of endocrine disrupters
J. Clin. Endocrinol. Metab.
87
1142-1150
2002
Homo sapiens
Manually annotated by BRENDA team
Pedersen, L.C.; Petrotchenko, E.; Shevtsov, S.; Negishi, M.
Crystal structure of the human estrogen sulfotransferase-PAPS complex: evidence for catalytic role of Ser137 in the sulfuryl transfer reaction
J. Biol. Chem.
277
17928-17932
2002
Homo sapiens (P49888)
Manually annotated by BRENDA team
van Lipzig, M.M.; Commandeur, J.N.; de Kanter, F.J.; Damsten, M.C.; Vermeulen, N.P.; Maat, E.; Groot, E.J.; Brouwer, A.; Kester, M.H.; Visser, T.J.; Meerman, J.H.
Bioactivation of dibrominated biphenyls by cytochrome P450 activity to metabolites with estrogenic activity and estrogen sulfotransferase inhibition capacity
Chem. Res. Toxicol.
18
1691-1700
2005
Homo sapiens
Manually annotated by BRENDA team
Harris, R.M.; Wood, D.M.; Bottomley, L.; Blagg, S.; Owen, K.; Hughes, P.J.; Waring, R.H.; Kirk, C.J.
Phytoestrogens are potent inhibitors of estrogen sulfation: implications for breast cancer risk and treatment
J. Clin. Endocrinol. Metab.
89
1779-1787
2004
Homo sapiens
Manually annotated by BRENDA team
Stanley, E.L.; Hume, R.; Coughtrie, M.W.H.
Expression profiling of human fetal cytosolic sulfotransferases involved in steroid and thyroid hormone metabolism and in detoxification
Mol. Cell. Endocrinol.
240
32-42
2005
Homo sapiens
Manually annotated by BRENDA team
Pasqualini, J.R.; Chetrite, G.S.
Correlation of estrogen sulfotransferase activity and proliferation in normal and carcinomatous human breast. A hypothesis
Anticancer Res.
27
3219-3225
2007
Homo sapiens
Manually annotated by BRENDA team
King, R.S.; Ghosh, A.A.; Wu, J.
Inhibition of human phenol and estrogen sulfotransferase by certain non-steroidal anti-inflammatory agents
Curr. Drug Metab.
7
745-753
2006
Homo sapiens (P49888)
Manually annotated by BRENDA team
Kapoor, R.; Nimmagadda, D.; Sheng, J.J.
Cellular localization studies on human estrogen sulfotransferase SULT1E1 in human embryonic kidney 293 cells
Drug Metab. Dispos.
35
17-20
2007
Homo sapiens, Homo sapiens (P49888)
Manually annotated by BRENDA team
Ung, D.; Nagar, S.
Variable sulfation of dietary polyphenols by recombinant human sulfotransferase (SULT) 1A1 genetic variants and SULT1E1
Drug Metab. Dispos.
35
740-746
2007
Homo sapiens, Homo sapiens (P49888)
Manually annotated by BRENDA team
Furimsky, A.M.; Green, C.E.; Hunt Sharp, L.E.; Catz, P.; Adjei, A.A.; Parman, T.; Kapetanovic, I.M.; Weinshilboum, R.M.; Iyer, L.V.
Effect of resveratrol on 17{beta}-estradiol sulfation by human hepatic and jejunal S9 and recombinant SULT1E1
Drug Metab. Dispos.
36
129-136
2008
Homo sapiens
Manually annotated by BRENDA team
Hoff, R.H.; Czyryca, P.G.; Sun, M.; Leyh, T.S.; Hengge, A.C.
Transition state of the sulfuryl transfer reaction of estrogen sulfotransferase
J. Biol. Chem.
281
30645-30649
2006
Homo sapiens
Manually annotated by BRENDA team
Hudelist, G.; Wuelfing, P.; Kersting, C.; Burger, H.; Mattsson, B.; Czerwenka, K.; Kubista, E.; Gschwantler-Kaulich, D.; Fink-Retter, A.; Singer, C.F.
Expression of aromatase and estrogen sulfotransferase in preinvasive and invasive breast cancer
J. Cancer Res. Clin. Oncol.
134
67-73
2008
Homo sapiens
Manually annotated by BRENDA team
Li, L.; Falany, C.N.
Elevated hepatic SULT1E1 activity in mouse models of cystic fibrosis alters the regulation of estrogen responsive proteins
J. Cyst. Fibros.
6
23-30
2007
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Allali-Hassani, A.; Pan, P.W.; Dombrovski, L.; Najmanovich, R.; Tempel, W.; Dong, A.; Loppnau, P.; Martin, F.; Thonton, J.; Edwards, A.M.; Bochkarev, A.; Plotnikov, A.N.; Vedadi, M.; Arrowsmith, C.H.
Structural and chemical profiling of the human cytosolic sulfotransferases
PLoS Biol.
5
1063-1078
2007
Homo sapiens (P49888)
-
Manually annotated by BRENDA team
Nakamura, Y.; Suzuki, T.; Fukuda, T.; Ito, A.; Endo, M.; Moriya, T.; Arai, Y.; Sasano, H.
Steroid sulfatase and estrogen sulfotransferase in human prostate cancer
Prostate
66
1005-1012
2006
Homo sapiens
Manually annotated by BRENDA team
Wang, M.; Ebmeier, C.C.; Olin, J.R.; Anderson, R.J.
Sulfation of tibolone metabolites by human postmenopausal liver and small intestinal sulfotransferases (SULTs)
Steroids
71
343-351
2006
Homo sapiens (P49888)
Manually annotated by BRENDA team
Prusakiewicz, J.J.; Harville, H.M.; Zhang, Y.; Ackermann, C.; Voorman, R.L.
Parabens inhibit human skin estrogen sulfotransferase activity: possible link to paraben estrogenic effects
Toxicology
232
248-256
2007
Homo sapiens
Manually annotated by BRENDA team
Maiti, S.; Zhang, J.; Chen, G.
Redox regulation of human estrogen sulfotransferase (hSULT1E1)
Biochem. Pharmacol.
73
1474-1481
2007
Homo sapiens
Manually annotated by BRENDA team
Hui, Y.; Yasuda, S.; Liu, M.Y.; Wu, Y.Y.; Liu, M.C.
On the sulfation and methylation of catecholestrogens in human mammary epithelial cells and breast cancer cells
Biol. Pharm. Bull.
31
769-773
2008
Homo sapiens
Manually annotated by BRENDA team
Svoboda, M.; Sellner, F.; Ekmekcioglu, C.; Klimpfinger, M.; Jaeger, W.; Thalhammer, T.
Expression of estrogen-metabolizing enzymes and estrogen receptors in cholelithiasis gallbladder
Biomed. Pharmacother.
62
690-696
2008
Homo sapiens
Manually annotated by BRENDA team
Hirata, H.; Hinoda, Y.; Okayama, N.; Suehiro, Y.; Kawamoto, K.; Kikuno, N.; Rabban, J.T.; Chen, L.M.; Dahiya, R.
CYP1A1, SULT1A1, and SULT1E1 polymorphisms are risk factors for endometrial cancer susceptibility
Cancer
112
1964-1973
2008
Homo sapiens
Manually annotated by BRENDA team
Gong, H.; Jarzynka, M.J.; Cole, T.J.; Lee, J.H.; Wada, T.; Zhang, B.; Gao, J.; Song, W.C.; DeFranco, D.B.; Cheng, S.Y.; Xie, W.
Glucocorticoids antagonize estrogens by glucocorticoid receptor-mediated activation of estrogen sulfotransferase
Cancer Res.
68
7386-7393
2008
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Sato, R.; Suzuki, T.; Katayose, Y.; Miura, K.; Shiiba, K.; Tateno, H.; Miki, Y.; Akahira, J.; Kamogawa, Y.; Nagasaki, S.; Yamamoto, K.; Ii, T.; Egawa, S.; Evans, D.B.; Unno, M.; Sasano, H.
Steroid sulfatase and estrogen sulfotransferase in colon carcinoma: regulators of intratumoral estrogen concentrations and potent prognostic factors
Cancer Res.
69
914-922
2009
Homo sapiens
Manually annotated by BRENDA team
Kapoor, R.; Sheng, J.J.
Transfection of human prostate cancer CA-HPV-10 cells with cytosolic sulfotransferase SULT1E1 affects estrogen signaling and gene transcription
Drug Metab. Dispos.
36
316-321
2008
Homo sapiens
Manually annotated by BRENDA team
Cohen, S.; Laitman, Y.; Kaufman, B.; Milgrom, R.; Nir, U.; Friedman, E.
SULT1E1 and ID2 genes as candidates for inherited predisposition to breast and ovarian cancer in Jewish women
Fam. Cancer
8
135-144
2008
Homo sapiens
Manually annotated by BRENDA team
Gonzalez, A.; Cos, S.; Martinez-Campa, C.; Alonso-Gonzalez, C.; Sanchez-Mateos, S.; Mediavilla, M.D.; Sanchez-Barcelo, E.J.
Selective estrogen enzyme modulator actions of melatonin in human breast cancer cells
J. Pineal Res.
45
86-92
2008
Homo sapiens
Manually annotated by BRENDA team
Bacallao, K.; Leon, L.; Gabler, F.; Soto, E.; Romero, C.; Valladares, L.; Vega, M.
In situ estrogen metabolism in proliferative endometria from untreated women with polycystic ovarian syndrome with and without endometrial hyperplasia
J. Steroid Biochem. Mol. Biol.
110
163-169
2008
Homo sapiens
Manually annotated by BRENDA team
Svoboda, M.; Thalhammer, T.; Aust, S.; Arrich, F.; Assadian, O.; Toma, C.D.
Estrogen sulfotransferase (SULT1E1) expression in benign and malignant human bone tumors
J. Surg. Oncol.
95
572-581
2007
Homo sapiens
Manually annotated by BRENDA team
Hudelist, G.; Czerwenka, K.; Keckstein, J.; Haas, C.; Fink-Retter, A.; Gschwantler-Kaulich, D.; Kubista, E.; Singer, C.F.
Expression of aromatase and estrogen sulfotransferase in eutopic and ectopic endometrium: evidence for unbalanced estradiol production in endometriosis
Reprod. Sci.
14
798-805
2007
Homo sapiens
Manually annotated by BRENDA team
Campisi, I.; Granata, O.M.; Cocciadiferro, L.; Calabro, M.; Polito, L.M.; Carruba, G.
16alpha-hydroxyestrone inhibits estrogen sulfotransferase activity in human liver cancer cells
Ann. N. Y. Acad. Sci.
1155
237-241
2009
Homo sapiens
Manually annotated by BRENDA team
Sasano, H.; Nagasaki, S.; Miki, Y.; Suzuki, T.
New developments in intracrinology of human breast cancer: estrogen sulfatase and sulfotransferase
Ann. N. Y. Acad. Sci.
1155
76-79
2009
Homo sapiens
Manually annotated by BRENDA team
Pasqualini, J.R.
Estrogen sulfotransferases in breast and endometrial cancers
Ann. N. Y. Acad. Sci.
1155
88-98
2009
Homo sapiens
Manually annotated by BRENDA team
Senggunprai, L.; Yoshinari, K.; Yamazoe, Y.
Inhibitory effects of kynurenic acid, a tryptophan metabolite, and its derivatives on cytosolic sulfotransferases
Biochem. J.
422
455-462
2009
Homo sapiens (P49888)
Manually annotated by BRENDA team
He, D.; Wilborn, T.W.; Falany, J.L.; Li, L.; Falany, C.N.
Repression of CFTR activity in human MMNK-1 cholangiocytes induces sulfotransferase 1E1 expression in co-cultured HepG2 hepatocytes
Biochim. Biophys. Acta
1783
2391-2397
2008
Homo sapiens
Manually annotated by BRENDA team
Falany, C.N.; He, D.; Li, L.; Falany, J.L.; Wilborn, T.W.; Kocarek, T.A.; Runge-Morris, M.
Regulation of hepatic sulfotransferase (SULT) 1E1 expression and effects on estrogenic activity in cystic fibrosis (CF)
J. Steroid Biochem. Mol. Biol.
114
113-119
2009
Homo sapiens
Manually annotated by BRENDA team
Ung, D.; Nagar, S.
Trans-resveratrol-mediated inhibition of beta-oestradiol conjugation in MCF-7 cells stably expressing human sulfotransferases SULT1A1 or SULT1E1, and human liver microsomes
Xenobiotica
39
72-79
2009
Homo sapiens
Manually annotated by BRENDA team
Suzuki, T.; Miki, Y.; Nakamura, Y.; Ito, K.; Sasano, H.
Steroid sulfatase and estrogen sulfotransferase in human carcinomas
Mol. Cell. Endocrinol.
340
148-153
2011
Homo sapiens
Manually annotated by BRENDA team
Sun, M.; Leyh, T.S.
The human estrogen sulfotransferase: a half-site reactive enzyme
Biochemistry
49
4779-4785
2010
Homo sapiens
Manually annotated by BRENDA team
Amar, D.; Berger, I.; Amara, N.; Tafa, G.; Meijler, M.M.; Aharoni, A.
The transition of human estrogen sulfotransferase from generalist to specialist using directed enzyme evolution
J. Mol. Biol.
416
21-32
2012
Homo sapiens (P49888)
Manually annotated by BRENDA team
Xu, Y.; Yang, X.; Wang, Z.; Li, M.; Ning, Y.; Chen, S.; Yin, L.; Li, X.
Estrogen sulfotransferase (SULT1E1) regulates inflammatory response and lipid metabolism of human endothelial cells via PPARgamma
Mol. Cell. Endocrinol.
369
140-149
2013
Homo sapiens, Homo sapiens (P49888)
Manually annotated by BRENDA team
Iida, S.; Kakinuma, H.; Miki, Y.; Abe, K.; Sakurai, M.; Suzuki, S.; Niikawa, H.; Akahira, J.; Suzuki, T.; Sasano, H.
Steroid sulphatase and oestrogen sulphotransferase in human non-small-cell lung carcinoma
Br. J. Cancer
108
1415-1424
2013
Homo sapiens
Manually annotated by BRENDA team
Rizner, T.L.
The important roles of steroid sulfatase and sulfotransferases in gynecological diseases
Front. Pharmacol.
7
30
2016
Homo sapiens (P49888)
Manually annotated by BRENDA team
Narukawa, Y.; Niimura, A.; Noguchi, H.; Tamura, H.; Kiuchi, F.
New diterpenoids with estrogen sulfotransferase inhibitory activity from Leonurus sibiricus L.
J. Nat. Med.
68
125-131
2014
Homo sapiens (P49888)
Manually annotated by BRENDA team
Piccinato, C.A.; Neme, R.M.; Torres, N.; Sanches, L.R.; Derogis, P.B.; Brudniewski, H.F.; Rosa e Silva, J.C.; Ferriani, R.A.
Effects of steroid hormone on estrogen sulfotransferase and on steroid sulfatase expression in endometriosis tissue and stromal cells
J. Steroid Biochem. Mol. Biol.
158
117-126
2016
Homo sapiens (P49888)
Manually annotated by BRENDA team
Ihunnah, C.A.; Wada, T.; Philips, B.J.; Ravuri, S.K.; Gibbs, R.B.; Kirisci, L.; Rubin, J.P.; Marra, K.G.; Xie, W.
Estrogen sulfotransferase/SULT1E1 promotes human adipogenesis
Mol. Cell. Biol.
34
1682-1694
2014
Homo sapiens (P49888)
Manually annotated by BRENDA team
Li, Y.; Xu, Y.; Li, X.; Qin, Y.; Hu, R.
Effects of PPAR-alpha agonist and IGF-1 on estrogen sulfotransferase in human vascular endothelial and smooth muscle cells
Mol. Med. Rep.
8
133-139
2013
Homo sapiens (P49888)
Manually annotated by BRENDA team
Wang, X.; Chen, X.; Feng, X.; Chang, F.; Chen, M.; Xia, Y.; Chen, L.
Triclosan causes spontaneous abortion accompanied by decline of estrogen sulfotransferase activity in humans and mice
Sci. Rep.
5
18252
2015
Mus musculus, Homo sapiens (P49888)
Manually annotated by BRENDA team
Garbacz, W.G.; Jiang, M.; Xie, W.
Sex-dependent role of estrogen sulfotransferase and steroid sulfatase in metabolic homeostasis
Adv. Exp. Med. Biol.
1043
455-469
2017
Homo sapiens (P49888), Mus musculus (P49891), Mus musculus C57BL/6J (P49891)
Manually annotated by BRENDA team
Sun, Y.; Machalz, D.; Wolber, G.; Parr, M.; Bureik, M.
Functional expression of all human sulfotransferases in fission yeast, assay development, and structural models for isoforms SULT4A1 and SULT6B1
Biomolecules
10
1-17
2020
Homo sapiens (P49888)
Manually annotated by BRENDA team
Yip, C.K.Y.; Bansal, S.; Wong, S.Y.; Lau, A.J.
Identification of galeterone and abiraterone as inhibitors of dehydroepiandrosterone sulfonation catalyzed by human hepatic cytosol, SULT2A1, SULT2B1b, and SULT1E1
Drug Metab. Dispos.
46
470-482
2018
Homo sapiens (P49888)
Manually annotated by BRENDA team
Parker, V.S.; Squirewell, E.J.; Lehmler, H.J.; Robertson, L.W.; Duffel, M.W.
Hydroxylated and sulfated metabolites of commonly occurring airborne polychlorinated biphenyls inhibit human steroid sulfotransferases SULT1E1 and SULT2A1
Environ. Toxicol. Pharmacol.
58
196-201
2018
Homo sapiens (P49888)
Manually annotated by BRENDA team
Rizner, T.L.
The important roles of steroid sulfatase and sulfotransferases in gynecological diseases
Front. Pharmacol.
7
30
2016
Homo sapiens (P49888)
Manually annotated by BRENDA team
Sato, A.; Yamazaki, M.; Watanabe, H.; Sakurai, E.; Ebina, K.
Human estrogen sulfotransferase and its related fluorescently labeled decapeptides specifically interact with oxidized low-density lipoprotein
J. Pept. Sci.
26
e3274
2020
Homo sapiens (P49888), Homo sapiens
Manually annotated by BRENDA team
Nazmeen, A.; Maiti, S.
Oxidant stress induction and signalling in xenografted (human breast cancer-tissues) plus estradiol treated or N-ethyl-N-nitrosourea treated female rats via altered estrogen sulfotransferase (rSULT1E1) expressions and SOD1/catalase regulations
Mol. Biol. Rep.
45
2571-2584
2018
Homo sapiens (P49888), Homo sapiens, Rattus norvegicus (P52844), Rattus norvegicus Wistar (P52844)
Manually annotated by BRENDA team
Nazmeen, A.; Chen, G.; Maiti, S.
Dependence between estrogen sulfotransferase (SULT1E1) and nuclear transcription factor Nrf-2 regulations via oxidative stress in breast cancer
Mol. Biol. Rep.
47
4691-4698
2020
Homo sapiens (P49888)
Manually annotated by BRENDA team
Mungenast, F.; Aust, S.; Vergote, I.; Vanderstichele, A.; Sehouli, J.; Braicu, E.; Mahner, S.; Castillo-Tong, D.C.; Zeillinger, R.; Thalhammer, T.
Clinical significance of the estrogen-modifying enzymes steroid sulfatase and estrogen sulfotransferase in epithelial ovarian cancer
Oncol. Lett.
13
4047-4054
2017
Homo sapiens (P49888)
Manually annotated by BRENDA team