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3'-phosphoadenylyl sulfate + keratan
adenosine 3',5'-bisphosphate + keratan 6'-sulfate
3'-phosphoadenylyl sulfate + N-acetyllactosamine
adenosine 3',5'-bisphosphate + 6'-sulfo N-acetyllactosamine
-
-
-
-
?
3'-phosphoadenylylsulfate + agarose
adenosine 3',5'-bisphosphate + ?
-
sulfotransferase I active, sulfotransferase II not
-
-
?
3'-phosphoadenylylsulfate + chitin dodecylsaccharide
adenosine 3',5'-bisphosphate + ?
-
sulfotransferase I and II
-
-
?
3'-phosphoadenylylsulfate + fetuin
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylylsulfate + GlcNAcbeta1-3Galbeta1-4GlcNACbeta1-3Galbeta1-4GlcNAcbeta1-6Manalpha1-6Manbeta-octyl
adenosine 3',5'-bisphosphate + ?
-
synthetic substrate, sulfation at position 6 of N-acetylgalactosamine residues, GlcNAc 6-O-sulfotransferase
-
-
?
3'-phosphoadenylylsulfate + GlyCAM-1
adenosine 3',5'-bisphosphate + ?
-
endothelial mucin-like ligand for L-selectin, products correspond to [SO3-6]GlcNAc and Galbeta1-4[SO3-6]GlcNAc
-
-
?
3'-phosphoadenylylsulfate + keratan sulfate
adenosine 3',5'-bisphosphate + keratan 6'-sulfate
3'-phosphoadenylylsulfate + NeuAcalpha2-3Galbeta1(6-sulfo)GlcNAcbeta1-3(6-sulfo)Galbeta1-4(6-sulfo)GlcNAc
adenosine 3',5'-bisphosphate + NeuAcalpha2-3-(6-sulfo)Galbeta1-(6-sulfo)GlcNAcbeta1-3(6-sulfo)Galbeta1-4(6-sulfo)GlcNAc
-
sulfation at position 6 of Gal residues
-
-
?
3'-phosphoadenylylsulfate + NeuAcalpha2-3Galbeta1-4GlcNAc
adenosine 3',5'-bisphosphate + NeuAcalpha2-3(6-sulfo)Galbeta1-4GlcNAc
-
sulfation at position 6 of Gal residues, no sulfation of GlcNAc
-
-
?
3'-phosphoadenylylsulfate + NeuAcalpha2-3Galbeta1-4GlcNAcbeta1-3Galbeta1-4GlcNAc
adenosine 3',5'-bisphosphate + ?
-
sulfation at position 6 of Gal residues
-
-
?
3'-phosphoadenylylsulfate + pyridylamino-GlcNAcbeta1-3Galbeta1-4GlcNAc
adenosine 3',5'-bisphosphate + pyridylamino-GlcNAcbeta1-3Galbeta1-4(6-sulfo)GlcNAc
-
sulfation at GlcNAc residues at the nonreducing end but no sulfation of internal GlcNAc
-
-
?
additional information
?
-
3'-phosphoadenylyl sulfate + keratan
adenosine 3',5'-bisphosphate + keratan 6'-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + keratan
adenosine 3',5'-bisphosphate + keratan 6'-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + keratan
adenosine 3',5'-bisphosphate + keratan 6'-sulfate
keratan sulfate proteoglycan is expressed in the extracellular matrix or cell surface in numerous tissues, predominantly in those of the cornea, cartilage, and brain
-
-
?
3'-phosphoadenylyl sulfate + keratan
adenosine 3',5'-bisphosphate + keratan 6'-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + keratan
adenosine 3',5'-bisphosphate + keratan 6'-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + keratan
adenosine 3',5'-bisphosphate + keratan 6'-sulfate
pericellular localization of R-10G reactive KS epitopes in perineuronal net-positive neurons in the visual cortex of adult mice
-
-
?
3'-phosphoadenylyl sulfate + keratan
adenosine 3',5'-bisphosphate + keratan 6'-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + keratan
adenosine 3',5'-bisphosphate + keratan 6'-sulfate
pericellular localization of R-10G reactive KS epitopes in perineuronal net-positive neurons in the visual cortex of adult mice
-
-
?
3'-phosphoadenylylsulfate + keratan sulfate
adenosine 3',5'-bisphosphate + keratan 6'-sulfate
-
both enzyme species react best with keratan sulfate segments exhibiting a relatively high degree of sulfation
specificity, sulfotransferase I: 60% of the sulfate ester groups formed are linked to the C-6 atom of galactosyl residues, the rest to the C-6 atom of N-acetylglucosamine, sulfotransferase II: 23% of the newly formed sulfate ester groups are on galactosyl and 77% on N-acetylglucosaminyl residues
?
3'-phosphoadenylylsulfate + keratan sulfate
adenosine 3',5'-bisphosphate + keratan 6'-sulfate
-
activity decreases with increasing molecular mass and sulfation degree of keratan sulfate
-
?
3'-phosphoadenylylsulfate + keratan sulfate
adenosine 3',5'-bisphosphate + keratan 6'-sulfate
-
no activity with keratansulfate-derived oligosaccharides
specificity, sulfotransferase I: 60% of the sulfate ester groups formed are linked to the C-6 atom of galactosyl residues, the rest to the C-6 atom of N-acetylglucosamine, sulfotransferase II: 23% of the newly formed sulfate ester groups are on galactosyl and 77% on N-acetylglucosaminyl residues
?
3'-phosphoadenylylsulfate + keratan sulfate
adenosine 3',5'-bisphosphate + keratan 6'-sulfate
-
very weak activity towards desulfated keratan sulfate
specificity, sulfotransferase I: 60% of the sulfate ester groups formed are linked to the C-6 atom of galactosyl residues, the rest to the C-6 atom of N-acetylglucosamine, sulfotransferase II: 23% of the newly formed sulfate ester groups are on galactosyl and 77% on N-acetylglucosaminyl residues
?
3'-phosphoadenylylsulfate + keratan sulfate
adenosine 3',5'-bisphosphate + keratan 6'-sulfate
-
partially desulfated
specificity, sulfotransferase I: 60% of the sulfate ester groups formed are linked to the C-6 atom of galactosyl residues, the rest to the C-6 atom of N-acetylglucosamine, sulfotransferase II: 23% of the newly formed sulfate ester groups are on galactosyl and 77% on N-acetylglucosaminyl residues
?
3'-phosphoadenylylsulfate + keratan sulfate
adenosine 3',5'-bisphosphate + keratan 6'-sulfate
-
-
-
-
?
3'-phosphoadenylylsulfate + keratan sulfate
adenosine 3',5'-bisphosphate + keratan 6'-sulfate
sulfation at position 6 of Gal residues which are adjacent to GlcNAc(6S) or GlcNAc
-
-
?
3'-phosphoadenylylsulfate + keratan sulfate
adenosine 3',5'-bisphosphate + keratan 6'-sulfate
-
sulfation at position 6 of N-acetylgalactosamine residues, GlcNAc 6-O-sulfotransferase
-
-
?
3'-phosphoadenylylsulfate + keratan sulfate
adenosine 3',5'-bisphosphate + keratan 6'-sulfate
-
sulfation at position 6 of N-acetylgalactosamine residues, GlcNAc 6-O-sulfotransferase
-
-
?
additional information
?
-
-
N-acetylglucosamine residues do not act as acceptors
-
-
?
additional information
?
-
-
sulfation of GlcNAc is coupled to enlongation of keratan sulfate chain
-
-
?
additional information
?
-
no activity towards chondroitin, chondroitin sulfate, dermatan sulfate or CDSNS-heparinn
-
-
?
additional information
?
-
-
no activity towards chondroitin, chondroitin sulfate, dermatan sulfate or CDSNS-heparinn
-
-
?
additional information
?
-
-
Gn6ST produces keratan sulfate in cooperation with KSG6ST, inactivation of Gn6ST may lead to macular corneal dystrophy
-
-
?
additional information
?
-
-
loss of GST-4beta causes macular corneal dystrophy
-
-
?
additional information
?
-
sulfation of GlcNAc residues precedes sulfation of Gal residues during biosynthesis of keratan sulfate
-
-
?
additional information
?
-
-
sulfation of GlcNAc residues precedes sulfation of Gal residues during biosynthesis of keratan sulfate
-
-
?
additional information
?
-
-
KSST competes with fucosyltransferase-VII for the same acceptor substrate and downregulates the synthesis of L-selectin ligand by inhibiting alpha1,3-fucosylation, sulfated oligosaccharide, e.g. 6'-sulfated galactose residues, increase in FucT-VII-deficient mutant mice, structure of mono-sulfated O-glycans, detailed overview
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
3'-phosphoadenylyl sulfate + keratan
adenosine 3',5'-bisphosphate + keratan 6'-sulfate
3'-phosphoadenylyl sulfate + N-acetyllactosamine
adenosine 3',5'-bisphosphate + 6'-sulfo N-acetyllactosamine
-
-
-
-
?
additional information
?
-
3'-phosphoadenylyl sulfate + keratan
adenosine 3',5'-bisphosphate + keratan 6'-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + keratan
adenosine 3',5'-bisphosphate + keratan 6'-sulfate
keratan sulfate proteoglycan is expressed in the extracellular matrix or cell surface in numerous tissues, predominantly in those of the cornea, cartilage, and brain
-
-
?
3'-phosphoadenylyl sulfate + keratan
adenosine 3',5'-bisphosphate + keratan 6'-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + keratan
adenosine 3',5'-bisphosphate + keratan 6'-sulfate
pericellular localization of R-10G reactive KS epitopes in perineuronal net-positive neurons in the visual cortex of adult mice
-
-
?
3'-phosphoadenylyl sulfate + keratan
adenosine 3',5'-bisphosphate + keratan 6'-sulfate
pericellular localization of R-10G reactive KS epitopes in perineuronal net-positive neurons in the visual cortex of adult mice
-
-
?
additional information
?
-
-
sulfation of GlcNAc is coupled to enlongation of keratan sulfate chain
-
-
?
additional information
?
-
-
Gn6ST produces keratan sulfate in cooperation with KSG6ST, inactivation of Gn6ST may lead to macular corneal dystrophy
-
-
?
additional information
?
-
-
loss of GST-4beta causes macular corneal dystrophy
-
-
?
additional information
?
-
sulfation of GlcNAc residues precedes sulfation of Gal residues during biosynthesis of keratan sulfate
-
-
?
additional information
?
-
-
sulfation of GlcNAc residues precedes sulfation of Gal residues during biosynthesis of keratan sulfate
-
-
?
additional information
?
-
-
KSST competes with fucosyltransferase-VII for the same acceptor substrate and downregulates the synthesis of L-selectin ligand by inhibiting alpha1,3-fucosylation, sulfated oligosaccharide, e.g. 6'-sulfated galactose residues, increase in FucT-VII-deficient mutant mice, structure of mono-sulfated O-glycans, detailed overview
-
-
?
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Rter, E.R.; Kresse, H.
Partial purification and characterization of 3-phosphoadenylylsulfate:keratan sulfate sulfotransferases
J. Biol. Chem.
259
11771-11776
1984
Bos taurus
brenda
Keller, R.; Driesch, R.; Stein, T.; Momburg, M.; Stuhlsatz, H.W.; Greiling, H.
Biosynthesis of proteokeratan sulfate in the bovine cornea. 1. Isolation and characterization of a keratan sulfotransferase and the role of sulfation for the chain termination
Hoppe-Seyler's Z. Physiol. Chem.
364
239-252
1983
Bos taurus
brenda
Keller, R.; Stein, T.; Weber, W.; Kehrer, T.; Stuhlsatz, H.W.; Greiling, H.
Biosynthesis of proteokeratan sulfate in the bovine cornea. 2. Isolation of subcellular membrane fragments from bovine cornea cells with keratan sulfate synthesizing activity
Hoppe-Seyler's Z. Physiol. Chem.
364
253-260
1983
Bos taurus
brenda
Akama, T.O.; Nakayama, J.; Nishida, K.; Hiraoka, N.; Suzuki, M.; McAuliffe, J.; Hindsgaul, O.; Fukuda, M.; Fukuda, M.N.
Human corneal GlcNac 6-O-sulfotransferase and mouse intestinal GlcNac 6-O-sulfotransferase both produce keratan sulfate
J. Biol. Chem.
276
16271-16278
2001
Homo sapiens, Mus musculus
brenda
Bartes, A.; Bhakta, S.; Hemmerich, S.
Sulfation of endothelial mucin by corneal keratan N-acetylglucosamine 6-O-sulfotransferase (GST-4beta)
Biochem. Biophys. Res. Commun.
282
928-933
2001
Homo sapiens
brenda
Fukuta, M.; Inazawa, J.; Torii, T.; Tsuzuki, K.; Shimada, E.; Habuchi, O.
Molecular cloning and characterization of human keratan sulfate Gal-6-sulfotransferase
J. Biol. Chem.
272
32321-32328
1997
Homo sapiens (O43916), Homo sapiens
brenda
Torii, T.; Fukuta, M.; Habuchi, O.
Sulfation of sialyl N-acetyllactosamine oligosaccharides and fetuin oligosaccharides by keratan sulfate Gal-6-sulfotransferase
Glycobiology
10
203-211
2000
Homo sapiens
brenda
Yamamoto, Y.; Takahashi, I.; Ogata, N.; Nakazawa, K.
Purification and characterization of N-acetylglucosaminyl sulfotransferase from chick corneas
Arch. Biochem. Biophys.
392
87-92
2001
Gallus gallus
brenda
Hiraoka, N.; Petryniak, B.; Kawashima, H.; Mitoma, J.; Akama, T.O.; Fukuda, M.N.; Lowe, J.B.; Fukuda, M.
Significant decrease in alpha1,3-linked fucose in association with increase in 6-sulfated N-acetylglucosamine in peripheral lymph node addressin of FucT-VII-deficient mice exhibiting diminished lymphocyte homing
Glycobiology
17
277-293
2007
Mus musculus
brenda
Hayatsu, N.; Ogasawara, S.; Kaneko, M.K.; Kato, Y.; Narimatsu, H.
Expression of highly sulfated keratan sulfate synthesized in human glioblastoma cells
Biochem. Biophys. Res. Commun.
368
217-222
2008
Homo sapiens (O43916), Homo sapiens
brenda
Tateno, H.; Ohnishi, K.; Yabe, R.; Hayatsu, N.; Sato, T.; Takeya, M.; Narimatsu, H.; Hirabayashi, J.
Dual specificity of Langerin to sulfated and mannosylated glycans via a single C-type carbohydrate recognition domain
J. Biol. Chem.
285
6390-6400
2009
Homo sapiens
brenda
Patnode, M.L.; Yu, S.Y.; Cheng, C.W.; Ho, M.Y.; Tegesjoe, L.; Sakuma, K.; Uchimura, K.; Khoo, K.H.; Kannagi, R.; Rosen, S.D.
KSGal6ST generates galactose-6-O-sulfate in high endothelial venules but does not contribute to L-selectin-dependent lymphocyte homing
Glycobiology
23
381-394
2013
Mus musculus
brenda
Fujimoto, H.; Ohgomori, T.; Abe, K.; Uchimura, K.; Kadomatsu, K.; Jinno, S.
Time-dependent localization of high- and low-sulfated keratan sulfates in the song nuclei of developing zebra finches
Eur. J. Neurosci.
42
2716-2725
2015
Taeniopygia guttata
brenda
Hoshino, H.; Foyez, T.; Ohtake-Niimi, S.; Takeda-Uchimura, Y.; Michikawa, M.; Kadomatsu, K.; Uchimura, K.
KSGal6ST is essential for the 6-sulfation of galactose within keratan sulfate in early postnatal brain
J. Histochem. Cytochem.
62
145-156
2014
Mus musculus (Q9EQC0)
brenda
Narentuya, ; Takeda-Uchimura, Y.; Foyez, T.; Zhang, Z.; Akama, T.O.; Yagi, H.; Kato, K.; Komatsu, Y.; Kadomatsu, K.; Uchimura, K.
GlcNAc6ST3 is a keratan sulfate sulfotransferase for the protein-tyrosine phosphatase PTPRZ in the adult brain
Sci. Rep.
9
4387
2019
Mus musculus (Q9QUP4), Mus musculus, Mus musculus C57BL/6 J (Q9QUP4)
brenda