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Information on EC 2.8.2.18 - cortisol sulfotransferase
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2.8.2.18 cortisol sulfotransferaseSpecify your search results
Word Map
- 2.8.2.18
- steroids
-
sulfotransferases
- testosterone
- stiii
- dehydroepiandrosterone
- estradiol-17beta
- androgen
- estradiol
-
castration
- 3'-phosphoadenosine-5'-phosphosulfate
-
ovariectomy
-
deae-sephadex
-
gonadal
- sephadex
-
text
- progesterone
- ni
-
ovariectomized
-
radioisotopic
- corticosterone
- p-hydroxymercuribenzoate
- estrogen
The enzyme appears in viruses and cellular organisms
Reaction Schemes
Synonyms
cortisol sulfotransferase, glucocorticoid sulfotransferase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
glucocorticoid sulfotransferase
-
-
-
-
glucocorticosteroid sulfotransferase
-
-
-
-
sulfotransferase, glucocorticoid
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
3'-phosphoadenylyl sulfate + cortisol = adenosine 3',5'-bisphosphate + cortisol 21-sulfate
3'-phosphoadenylyl sulfate + cortisol = adenosine 3',5'-bisphosphate + cortisol 21-sulfate
mechanism
-
3'-phosphoadenylyl sulfate + cortisol = adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
sulfate group transfer
-
-
-
-
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SYSTEMATIC NAME
IUBMB Comments
3'-phosphoadenylyl-sulfate:cortisol 21-sulfotransferase
-
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CAS REGISTRY NUMBER
COMMENTARY
71427-08-2
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
3'-phosphoadenylylsulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylylsulfate + deoxycorticosterone
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylylsulfate + estradiol-17beta
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylylsulfate + testosterone
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylylsulfate + cortisol
adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
-
-
?
3'-phosphoadenylylsulfate + cortisol
adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
-
-
-
?
3'-phosphoadenylylsulfate + cortisol
adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
-
-
?
3'-phosphoadenylylsulfate + cortisol
adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
-
-
-
?
3'-phosphoadenylylsulfate + cortisol
adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
no substrates are AMP, ADP, ATP or GTP
-
?
3'-phosphoadenylylsulfate + cortisol
adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
-
-
?
3'-phosphoadenylylsulfate + cortisol
adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
no substrates are AMP, ADP, ATP or GTP
-
?
3'-phosphoadenylylsulfate + cortisol
adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
-
-
-
?
3'-phosphoadenylylsulfate + cortisol
adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
-
-
?
3'-phosphoadenylylsulfate + cortisol
adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
requires 0.04 mM cortisol for maximal activity
-
?
3'-phosphoadenylylsulfate + cortisol
adenosine 3',5'-bisphosphate + cortisol 21-sulfate
Meriones sp.
-
-
-
-
?
3'-phosphoadenylylsulfate + cortisol
adenosine 3',5'-bisphosphate + cortisol 21-sulfate
Meriones sp.
-
-
-
?
3'-phosphoadenylylsulfate + cortisol
adenosine 3',5'-bisphosphate + cortisol 21-sulfate
Meriones sp.
-
requires 0.5 mM cortisol for maximal activity
-
?
3'-phosphoadenylylsulfate + cortisol
adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
-
-
-
?
3'-phosphoadenylylsulfate + cortisol
adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
-
-
?
3'-phosphoadenylylsulfate + cortisol
adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
requires 0.5 mM cortisol for maximal activity
-
?
3'-phosphoadenylylsulfate + cortisol
adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
-
-
-
?
3'-phosphoadenylylsulfate + cortisol
adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
-
-
?
3'-phosphoadenylylsulfate + cortisol
adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
-
-
-
?
3'-phosphoadenylylsulfate + cortisol
adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
-
-
?
3'-phosphoadenylylsulfate + cortisol
adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
-
-
?
3'-phosphoadenylylsulfate + cortisol
adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
-
-
-
?
3'-phosphoadenylylsulfate + cortisol
adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
i.e. PAPS, glucocorticoids are preferred substrates
-
-
?
3'-phosphoadenylylsulfate + cortisol
adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
i.e. PAPS, glucocorticoids are preferred substrates
-
?
additional information
?
-
-
sulfotransferase I is not as specific as sulfotransferase III
-
-
?
additional information
?
-
-
involved in control of corticosteroid metabolism
-
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
-
-
involved in control of corticosteroid metabolism
-
-
?
3'-phosphoadenylylsulfate + cortisol
adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
-
-
?
3'-phosphoadenylylsulfate + cortisol
adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
-
-
-
?
3'-phosphoadenylylsulfate + cortisol
adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
-
-
?
3'-phosphoadenylylsulfate + cortisol
adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
-
-
-
?
3'-phosphoadenylylsulfate + cortisol
adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
-
-
?
3'-phosphoadenylylsulfate + cortisol
adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
-
-
-
?
3'-phosphoadenylylsulfate + cortisol
adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
-
-
?
3'-phosphoadenylylsulfate + cortisol
adenosine 3',5'-bisphosphate + cortisol 21-sulfate
Meriones sp.
-
-
-
-
?
3'-phosphoadenylylsulfate + cortisol
adenosine 3',5'-bisphosphate + cortisol 21-sulfate
Meriones sp.
-
-
-
?
3'-phosphoadenylylsulfate + cortisol
adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
-
-
-
?
3'-phosphoadenylylsulfate + cortisol
adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
-
-
?
3'-phosphoadenylylsulfate + cortisol
adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
-
-
-
?
3'-phosphoadenylylsulfate + cortisol
adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
-
-
?
3'-phosphoadenylylsulfate + cortisol
adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
-
-
-
?
3'-phosphoadenylylsulfate + cortisol
adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
-
-
?
3'-phosphoadenylylsulfate + cortisol
adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
-
-
?
3'-phosphoadenylylsulfate + cortisol
adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
-
-
-
?
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Ba2+
Ca2+
Co2+
Cr2+
Fe3+
Mg2+
Mn2+
Ni2+
Ba2+
-
in decreasing order of efficiency: Cr2+, Mn2+, Co2+, Mg2+, Ni2+, Ca2+, Fe3+, Ba2+
Ba2+
-
in decreasing order of efficiency: Cr2+, Mg2+, Ba2+, Mn2+, Ni2+, Ca2+, Co2+
Ba2+
-
in decreasing order of efficiency: Mn2+, Cr2+, Co2+, Mg2+, Ba2+, Ca2+, Ni2+
Ca2+
-
in decreasing order of efficiency: Cr2+, Mn2+, Co2+, Mg2+, Ni2+, Ca2+, Fe3+, Ba2+
Ca2+
-
in decreasing order of efficiency: Mn2+, Cr2+, Co2+, Mg2+, Ba2+, Ca2+, Ni2+
Ca2+
-
in decreasing order of efficiency: Cr2+, Mg2+, Ba2+, Mn2+, Ni2+, Ca2+, Co2+
Co2+
-
in decreasing order of efficiency: Cr2+, Mn2+, Co2+, Mg2+, Ni2+, Ca2+, Fe3+, Ba2+
Co2+
-
in decreasing order of efficiency: Cr2+, Mg2+, Ba2+, Mn2+, Ni2+, Ca2+, Co2+
Co2+
-
in decreasing order of efficiency: Mn2+, Cr2+, Co2+, Mg2+, Ba2+, Ca2+, Ni2+
Cr2+
-
in decreasing order of efficiency: Cr2+, Mn2+, Co2+, Mg2+, Ni2+, Ca2+, Fe3+, Ba2+
Cr2+
-
in decreasing order of efficiency: Cr2+, Mg2+, Ba2+, Mn2+, Ni2+, Ca2+, Co2+
Cr2+
-
in decreasing order of efficiency: Mn2+, Cr2+, Co2+, Mg2+, Ba2+, Ca2+, Ni2+
Fe3+
-
in decreasing order of efficiency: Cr2+, Mn2+, Co2+, Mg2+, Ni2+, Ca2+, Fe3+, Ba2+
Mg2+
-
in decreasing order of efficiency: Cr2+, Mn2+, Co2+, Mg2+, Ni2+, Ca2+, Fe3+, Ba2+
Mg2+
-
in decreasing order of efficiency: Cr2+, Mg2+, Ba2+, Mn2+, Ni2+, Ca2+, Co2+
Mg2+
-
in decreasing order of efficiency: Mn2+, Cr2+, Co2+, Mg2+, Ba2+, Ca2+, Ni2+
Mn2+
-
in decreasing order of efficiency: Cr2+, Mn2+, Co2+, Mg2+, Ni2+, Ca2+, Fe3+, Ba2+
Mn2+
-
in decreasing order of efficiency: Cr2+, Mg2+, Ba2+, Mn2+, Ni2+, Ca2+, Co2+
Mn2+
-
in decreasing order of efficiency: Mn2+, Cr2+, Co2+, Mg2+, Ba2+, Ca2+, Ni2+
Ni2+
-
in decreasing order of efficiency: Cr2+, Mn2+, Co2+, Mg2+, Ni2+, Ca2+, Fe3+, Ba2+
Ni2+
-
in decreasing order of efficiency: Cr2+, Mg2+, Ba2+, Mn2+, Ni2+, Ca2+, Co2+
Ni2+
-
in decreasing order of efficiency: Mn2+, Cr2+, Co2+, Mg2+, Ba2+, Ca2+, Ni2+
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Hypertension
Hepatic cortisol sulfotransferase activity in several types of experimental hypertension in male rats.
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
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pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
37.5
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pI VALUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
Meriones sp.
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
partial
the use of frozen liver or cytosol stored on ice for more than 1-2 h reduces the yield of sulfotransferase I greatly
-
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Singer, S.S.; Gebhart, J.; Hess, E.
Enzymatic sulfation of steroids. V. Partial purification and some properties of sulfotransferase III, the major glucocorticoid sulfotransferase of liver cytosol from male rats
Can. J. Biochem.
56
1028-1035
1978
Rattus norvegicus
brenda
Singer, S.S.; Brill, B.
Enzymatic sulfation of steroids. XVII. The properties of the glucocorticoid sulfotransferase activity of guinea pig liver cytosol
Biochim. Biophys. Acta
712
590-596
1982
Cavia porcellus, Rattus norvegicus, Cavia porcellus Hartley
brenda
Singer, S.S.
Partial purification and some properties of rat liver sulfotransferase I, a glucocorticoid sulfotransferase usually restricted to female rats
Arch. Biochem. Biophys.
196
340-349
1979
Rattus norvegicus
brenda
Singer, S.S.; Bruns, L.
Enzymatic sulfation of steroids. XI. The extensive purification and some properties of hepatic sulfotransferase III from female rats
Can. J. Biochem.
58
660-666
1980
Rattus norvegicus
brenda
Federspeil, M.J.; Singer, S.S.
Enzymatic sulfation of steroids. XIV. The glucocorticoid sulfotransferases of Bos Taurus liver
Comp. Biochem. Physiol. B
69
511-516
1981
Bos taurus, Rattus norvegicus
-
brenda
Singer, S.S.
Glucocorticoid sulphotransferases in rats and other animal species
Biochem. Soc. Trans.
12
35-39
1984
Bos taurus, Cavia porcellus, Gallus gallus, Meriones sp., Mesocricetus auratus, Rattus norvegicus
brenda
Singer, S.S.; Galaska, E.G.; Feeser, T.A.; Benak, R.L.; Ansel, A.Z.; Moloney, A.
Enzymic sulfation of steroids. XIX. Cortisol sulfotransferase activity, glucocorticoid sulfotransferases, and tyrosine aminotransferase induction in chicken, gerbil, and hamster liver
Can. J. Biochem. Cell Biol.
63
23-32
1985
Gallus gallus, Meriones sp., Mesocricetus auratus
brenda
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