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Information on EC 2.7.8.5 - CDP-diacylglycerol-glycerol-3-phosphate 1-phosphatidyltransferase and Organism(s) Homo sapiens

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IUBMB Comments
The enzyme catalyses the committed step in the biosynthesis of acidic phospholipids known by the common names phophatidylglycerols and cardiolipins.
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This record set is specific for:
Homo sapiens
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The taxonomic range for the selected organisms is: Homo sapiens
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
phosphatidylglycerophosphate synthase, pgp synthase, phosphatidylglycerolphosphate synthase, phosphatidylglycerophosphate synthetase, pgs1p, phosphatidylglycerol phosphate synthase, cgpgs1, phosphatidylglycerophosphate synthase 1, sn-glycerol-3-phosphate phosphatidyltransferase, phosphatidylglycerol phosphate synthetase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
3-phosphatidyl 1'-glycerol-3'-phosphate synthase
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CDP-diacylglycerol-sn-glycerol-3-phosphate 3-phosphatidyltransferase
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CDP-diacylglycerol:glycerol-3-phosphate phosphatidyltransferase
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CDP-diacylglycerol:sn-glycero-3-phosphate phosphatidyltransferase
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cytidine 5'-diphospho-1,2-diacyl-sn-glycerol(CDP-diglyceride):sn-glycerol-3-phosphate phosphatidyltransferase
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cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:sn-glycerol-3-phosphate phosphatidyltransferase (CDP-diglyceride)
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glycerol 3-phosphate phosphatidyltransferase
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glycerol phosphate phosphatidyltransferase
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glycerophosphate phosphatidyltransferase
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PGP synthase
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PGP synthase 1
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PGPS
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PGS
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phosphatidylglycerol phosphate synthase
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phosphatidylglycerol phosphate synthetase
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phosphatidylglycerolphosphate synthase
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phosphatidylglycerophosphate synthase
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phosphatidylglycerophosphate synthase 1
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phosphatidylglycerophosphate synthetase
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phosphatidyltransferase, glycerol phosphate
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sn-glycerol-3-phosphate phosphatidyltransferase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
substituted phospho group transfer
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PATHWAY SOURCE
PATHWAYS
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-, -, -, -, -, -
SYSTEMATIC NAME
IUBMB Comments
CDP-diacylglycerol:sn-glycerol-3-phosphate 1-(3-sn-phosphatidyl)transferase
The enzyme catalyses the committed step in the biosynthesis of acidic phospholipids known by the common names phophatidylglycerols and cardiolipins.
CAS REGISTRY NUMBER
COMMENTARY hide
9068-49-9
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
CDP-diacylglycerol + sn-glycerol 3-phosphate
CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate
show the reaction diagram
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-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
CDP-diacylglycerol + sn-glycerol 3-phosphate
CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate
show the reaction diagram
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-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
highest expression level of PGS1 mRNA
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
overexpression of phosphatidylglycerophosphate synthase 1, PGS1, increases the cellular contents of phosphatidylglycerol, cardiolipin, and phosphatidylcholine, and reduces that of phosphatidic acid. PGS1 overexpression also elevates the mitochondrial contents of cardiolipin and phosphatidylcholine, but has no effect on the number of mitochondria per cell
metabolism
in mammalian cells, phosphatidylglycerol is produced from CDP-diacylglycerol (CDP-DAG) through two steps catalyzed by phosphatidylglycerophosphate (PGP) synthase and PGP phosphatase. CDP-DAG is formed from phosphatidic acid (PA) by the enzymes CDP-DAG synthase 1 and 2, which are integral membrane proteins located to mitochondria and endoplasmic reticulum. CDP-DAG is converted to PGP by the action of the mitochondrial enzyme PGP synthase 1 (PGS1) through the exchange of glycerol-3-phosphate (G3P) with CMP moiety of CDP-DAG. Phosphatidylglycerophosphate is rapidly dephosphorylated to generate phosphatidylglycerol
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
PGPS1_HUMAN
556
0
62730
Swiss-Prot
Mitochondrion (Reliability: 3)
A0A024R8V5_HUMAN
556
0
62730
TrEMBL
Mitochondrion (Reliability: 3)
K7EJP6_HUMAN
264
0
29696
TrEMBL
other Location (Reliability: 3)
B4DL81_HUMAN
556
0
62731
TrEMBL
Mitochondrion (Reliability: 3)
K7EL44_HUMAN
384
0
43324
TrEMBL
Mitochondrion (Reliability: 3)
K7ELT9_HUMAN
329
0
37039
TrEMBL
Mitochondrion (Reliability: 2)
B4DLU3_HUMAN
421
0
47906
TrEMBL
other Location (Reliability: 2)
B7ZAU0_HUMAN
269
0
30444
TrEMBL
other Location (Reliability: 2)
K7EPX0_HUMAN
132
0
14595
TrEMBL
other Location (Reliability: 3)
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
gene PGS1, quantitative PCR enzyme expression analysis, recombinant overexpression of FLAG-tagged PGS1 in HEK-293 cells
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Morita, S.Y.; Terada, T.
Enzymatic measurement of phosphatidylglycerol and cardiolipin in cultured cells and mitochondria
Sci. Rep.
5
11737
2015
Homo sapiens (Q32NB8)
Manually annotated by BRENDA team