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Information on EC 2.7.8.2 - diacylglycerol cholinephosphotransferase and Organism(s) Mus musculus

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EC Tree
IUBMB Comments
1-Alkyl-2-acylglycerol can act as acceptor; this activity was previously listed separately.
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This record set is specific for:
Mus musculus
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Word Map
The taxonomic range for the selected organisms is: Mus musculus
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
cholinephosphotransferase, choline phosphotransferase, cept1, paf-cpt, diacylglycerol cholinephosphotransferase, dtt-insensitive cholinephosphotransferase, phosphorylcholine glyceride transferase, 1,2-diacylglycerol cholinephosphotransferase, aapt1, phosphatidylcholine:diacylglycerol cholinephosphotransferase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
1-alkyl-2-acetyl-m-glycerol:CDP-choline choline phosphotransferase
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1-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase
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1-alkyl-2-acetylglycerol cholinephosphotransferase
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AAPT
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alkylacylglycerol choline phosphotransferase
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alkylacylglycerol cholinephosphotransferase
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aminoalcoholphosphotransferase
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CDP-choline diglyceride phosphotransferase
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CEPT
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CEPT1
cf. EC 2.7.8.1
choline/ethanolaminephosphotransferase 1
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cholinephosphotransferase
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cholinephosphotransferase 1
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cholinephosphotransferase, 1-alkyl-2-acetylglycerol
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cholinephosphotransferase, diacylglycerol
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CPT
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cytidine diphosphocholine glyceride transferase
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cytidine diphosphorylcholine diglyceride transferase
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diacylglycerol choline phosphotransferase
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mCHPT1
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phosphocholine diacylglyceroltransferase
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phosphorylcholine-glyceride transferase
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sn-1,2-diacylglycerol cholinephosphotransferase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
CDP-choline + 1,2-diacyl-sn-glycerol = CMP + a phosphatidylcholine
show the reaction diagram
sequential kinetic mechanism
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
substituted phospho group transfer
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SYSTEMATIC NAME
IUBMB Comments
CDP-choline:1,2-diacyl-sn-glycerol cholinephosphotransferase
1-Alkyl-2-acylglycerol can act as acceptor; this activity was previously listed separately.
CAS REGISTRY NUMBER
COMMENTARY hide
77237-98-0
formerly, EC 2.7.8.16
9026-13-5
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
show the reaction diagram
-
-
-
?
CDP-choline + 1,2-dipalmitoyl-sn-glycerol
CMP + 1,2-dipalmitoyl-sn-glycero-3-phosphocholine
show the reaction diagram
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preferred substrate over other disaturated species
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?
additional information
?
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renal mRNA expression of cholinephosphotransferase 1 may be involved in the development and/or progression of diabetic nephropathy
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?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
additional information
?
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renal mRNA expression of cholinephosphotransferase 1 may be involved in the development and/or progression of diabetic nephropathy
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?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
CEPT1 is elevated in diseased lower extremity arterial intima of individuals with peripheral arterial disease and diabetes
Manually annotated by BRENDA team
CEPT1 is elevated in carotid plaque of patients with diabetes
Manually annotated by BRENDA team
CEPT1 is elevated in diseased lower extremity arterial intima of individuals with peripheral arterial disease and diabetes
Manually annotated by BRENDA team
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activity levels of glomerular putative mCHPT1 in BALB/c mice tend to be slightly higher than those in type 2 diabetic KK/Ta mice
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
endothelial cells of mice carrying a conditional endothelial cell-specific deletion of Cept1 demonstrate decreased proliferation, migration, and tubule formation, and mice carrying the conditional deletion have reduced perfusion and angiogenesis in ischemic hind-limbs. Peripheral ischemic recovery and PPARalpha signaling is further compromised by Streptozotocin-induced diabetes, and ameliorated by feeding fenofibrate
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
CHPT1_MOUSE
398
8
44608
Swiss-Prot
Mitochondrion (Reliability: 4)
CEPT1_MOUSE
416
8
46434
Swiss-Prot
other Location (Reliability: 5)
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Mantel, C.R.; Schulz, A.R.; Miyazawa, K.; Broxmeyer, H.E.
Kinetic selectivity of cholinephosphotransferase in mouse liver: the Km for CDP-choline depends on diacylglycerol structure
Biochem. J.
289
815-820
1993
Mus musculus
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Manually annotated by BRENDA team
Gohda, T.; Tanimoto, M.; Shiina, K.; Ito, T.; Kobayashi, M.; Hagiwara, S.; Kaneko, S.; Makita, Y.; Funabiki, K.; Horikoshi, S.; Tomino, Y.
Altered mouse cholinephosphotransferase gene expression in kidneys of type 2 diabetic KK/TA mouse
Metabolism
53
842-846
2004
Mus musculus
Manually annotated by BRENDA team
Zayed, M.A.; Jin, X.; Yang, C.; Belaygorod, L.; Engel, C.; Desai, K.; Harroun, N.; Saffaf, O.; Patterson, B.W.; Hsu, F.F.; Semenkovich, C.F.
CEPT1-mediated phospholipogenesis regulates endothelial cell function and ischemia-induced angiogenesis through PPARalpha
Diabetes
70
549-561
2020
Homo sapiens (Q9Y6K0), Homo sapiens, Mus musculus (Q8BGS7)
Manually annotated by BRENDA team