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EC Tree
The taxonomic range for the selected organisms is: Homo sapiens The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
phosphatidylinositol synthase, pi synthase, ptdins synthase, cdipt, zmpis, cdp-diglyceride:inositol transferase, cdp-dg:inositol transferase, pkpis, cdp-diacylglycerol-inositol 3-phosphatidyltransferase, bnptdins s1,
more
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CDP-DG:inositol transferase
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CDP-diacylglycerol-inositol phosphatidyltransferase
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CDP-diacylglycerol:myo-inositol-3-phosphatidyltransferase
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CDP-diglyceride-inositol phosphatidyltransferase
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CDP-diglyceride-inositol transferase
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CDP-diglyceride:inositol transferase
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CDPdiglyceride-inositol phosphatidyltransferase
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cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:myo-inositol 3-phosphatidyltransferase
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cytidine diphosphodiglyceride-inositol phosphatidyltransferase
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cytidine diphosphoglyceride-inositol phosphatidyltransferase
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cytidine diphosphoglyceride-inositol transferase
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phosphatidylinositol synthase
phosphatidylinositol synthase
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phosphatidylinositol synthase
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substituted phospho group transfer
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CDP-diacylglycerol:myo-inositol 3-phosphatidyltransferase
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2-deoxy-CDP-diacylglycerol + myo-inositol
CMP + ?
CDP-diacylglycerol + myo-inositol
CMP + 1-phosphatidyl-1D-myo-inositol
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
additional information
?
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UDP-diacylglycerol, ADP-diacylglycerol, and GDP-diacylglycerol are inactive as substrates
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?
2-deoxy-CDP-diacylglycerol + myo-inositol
CMP + ?
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r
2-deoxy-CDP-diacylglycerol + myo-inositol
CMP + ?
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optimal activity is 25% higher then with CDP-diacylglycerol
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r
CDP-diacylglycerol + myo-inositol
CMP + 1-phosphatidyl-1D-myo-inositol
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?
CDP-diacylglycerol + myo-inositol
CMP + 1-phosphatidyl-1D-myo-inositol
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specificity of PI synthase for the substrates, no activity with 1L-myo-inositol 1-phosphate
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?
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
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r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
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r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
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r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
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r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
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key enzyme in cell membrane biosynthesis
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r
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CDP-diacylglycerol + myo-inositol
CMP + 1-phosphatidyl-1D-myo-inositol
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?
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
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r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
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r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
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r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
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key enzyme in cell membrane biosynthesis
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r
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Mn2+
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CDP
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competitive inhibition
CDP-diacylglycerol
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above 0.5 mM
hexachlorocyclohexane
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hexachlorocyclohexane
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inhibition is non-competitive and not specific for inositol processing enzymes
additional information
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AMP CMP, GMP, UMP, TMP, TDP, and GDP are not inhibitory, triphosphates are even more inhibitory than diphosphates
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additional information
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AMP CMP, GMP, UMP, TMP, TDP, and GDP are not inhibitory, triphosphates are even more inhibitory than diphosphates; no inhibition with 2-deoxy-CDP-diacylglycerol
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Astrocytoma
Subcellular distribution of agonist-stimulated phosphatidylinositol synthesis in 1321 N1 astrocytoma cells.
Carcinogenesis
Novel molecular targets of smokeless tobacco (khaini) in cell culture from oral hyperplasia.
Carcinoma
Clinical Significance of Phosphatidyl Inositol Synthase Overexpression in Oral Cancer.
Cataract
Phosphatidylinositol synthase is required for lens structural integrity and photoreceptor cell survival in the zebrafish eye.
Dehydration
Importance of inositols and their derivatives in cowpea under root dehydration: An omics perspective.
Diabetes Complications
Inhibition of phosphatidylinositol synthase by glucose in human retinal pigment epithelial cells.
Hepatomegaly
Lack of de novo phosphatidylinositol synthesis leads to endoplasmic reticulum stress and hepatic steatosis in cdipt-deficient zebrafish.
Mouth Neoplasms
Clinical Significance of Phosphatidyl Inositol Synthase Overexpression in Oral Cancer.
Neoplasms
Characterization of a salt-extractable phosphatidylinositol synthase from rat pituitary-tumour membranes.
Neoplasms
Organization of the phosphoinositide cycle. Assessment of inositol transferase activity in purified plasma membranes.
Seizures
Chronic epi-inositol has an anxiolytic-like effect in the plus-maze model in rats.
Squamous Cell Carcinoma of Head and Neck
Clinical Significance of Phosphatidyl Inositol Synthase Overexpression in Oral Cancer.
Starvation
Regulation of CDP-diacylglycerol synthesis and utilization by inositol and choline in Schizosaccharomyces pombe.
Tuberculosis
Definition of the first mannosylation step in phosphatidylinositol mannoside synthesis. PimA is essential for growth of mycobacteria.
Tuberculosis
Phosphatidylinositol is an essential phospholipid of mycobacteria.
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0.045
2-deoxy-CDP-diacylglycerol
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0.036
CDP-diacylglycerol
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0.28
myo-inositol
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0.28
myo-inositol
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pH 9.0, 37°C
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0.2
diphosphate
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0.2
diphosphate
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pH 9.0, 37°C
0.6
phosphate
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pH 9.0, 37°C
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9
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in glycylglycine/NaOH or glycine/NaOH buffer
8
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assay at
8
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in Tris/HCl buffer, maximal activity is 60% of the activity in glycylglycine/NaOH at pH 9.0, at pH 9.0 almost no activity in Tris/HCl buffer
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cell line A431
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human
Uniprot
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human
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carcinoma cell
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membrane-bound
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metabolism
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in eukarya, phosphatidylinositol (PI) is only biosynthesized from CDP-diacylglycerol (CDP-DAG) and inositol
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CDIPT_HUMAN
213
4
23539
Swiss-Prot
Secretory Pathway (Reliability: 4 )
A8K3L7_HUMAN
213
4
23539
TrEMBL
Secretory Pathway (Reliability: 4 )
B3KSW0_HUMAN
185
2
20246
TrEMBL
Secretory Pathway (Reliability: 1 )
Q53HA5_HUMAN
213
4
23558
TrEMBL
Secretory Pathway (Reliability: 4 )
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additional information
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an artificial gene construct for a protein homologous to phosphatidylinositol phosphate synthase of Mycobacterium tuberculosis and archaetidylinositol phosphate synthase of Methanothermobacter thermautotrophicus is cloned in Escherichia coli and introduced into Homo sapiens cells. The recombinant cells do not show phosphatidylinositol phosphate synthase or archaetidylinositol phosphate synthase activities. Phosphatidylinositol synthase and archaetidylinositol synthase activities are determined, 7 pmol/h/mg and 2 pmol/h/mg, respectively
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50
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half-life without substrates 20 min
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-20°C, frozen and stored or frozen in liquid nitrogen and subsequently stored, over 50% activity is lost after 24 h
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-60°C, frozen and stored or frozen in liquid nitrogen and subsequently stored, over 50% activity is lost after 24 h
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-80°C, regularly frozen in liqid N2, no detectable loss of activity is experienced during storage at -80°C for up to 2 months
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4°C, stored on ice, 10% of the activity is lost during 24 h
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yeast cDNA S45885 used to search, pis1 cDNA cloned and expressed in COS-7 cells
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Lykidis, A.; Jackson, P.; Rock, C.O.; Jackowski, S.
The role of CDP-diacylglycerol synthetase and phosphatidylinositol synthase activity levels in the regulation of cellular phosphatidylinositol content
J. Biol. Chem.
272
33402-33409
1997
Homo sapiens (O14735), Homo sapiens
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Imoto, M.; Taniguchi, Y.; Umezawa, K.
Inhibition of CDP-DG: inositol transferase by inostamycin
J. Biochem.
112
299-302
1992
Homo sapiens
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Antonsson, B.E.
Purification and characterization of phosphatidylinositol synthase from human placenta
Biochem. J.
297
517-522
1994
Homo sapiens
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Antonsson, B.
Phosphatidylinositol synthase from mammalian tissues
Biochim. Biophys. Acta
1348
179-186
1997
Bos taurus, Saccharomyces cerevisiae, Cavia porcellus, Gallus gallus, Oryctolagus cuniculus, Homo sapiens, Meleagris gallopavo, Rattus norvegicus
brenda
Morii, H.; Ogawa, M.; Fukuda, K.; Taniguchi, H.
Ubiquitous distribution of phosphatidylinositol phosphate synthase and archaetidylinositol phosphate synthase in bacteria and archaea, which contain inositol phospholipid
Biochem. Biophys. Res. Commun.
443
86-90
2013
Homo sapiens, Saccharomyces cerevisiae (P70500), Saccharomyces cerevisiae
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