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Information on EC 2.7.7.7 - DNA-directed DNA polymerase and Organism(s) Plasmodium falciparum

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EC Tree
     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.7 Nucleotidyltransferases
                2.7.7.7 DNA-directed DNA polymerase
IUBMB Comments
Catalyses DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time. Cannot initiate a chain de novo. Requires a primer, which may be DNA or RNA. See also EC 2.7.7.49 RNA-directed DNA polymerase.
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This record set is specific for:
Plasmodium falciparum
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Word Map
The taxonomic range for the selected organisms is: Plasmodium falciparum
The enzyme appears in selected viruses and cellular organisms
Synonyms
dna polymerase alpha, dna polymerase beta, dna polymerase iii, pol beta, klenow fragment, dna polymerase delta, taq dna polymerase, pol delta, pol alpha, dna polymerase gamma, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
deoxynucleate polymerase
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-
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deoxyribonucleate nucleotidyltransferase
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-
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deoxyribonucleic acid duplicase
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-
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deoxyribonucleic acid polymerase
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-
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deoxyribonucleic duplicase
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-
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deoxyribonucleic polymerase
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deoxyribonucleic polymerase I
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DNA duplicase
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DNA nucleotidyltransferase
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DNA nucleotidyltransferase (DNA-directed)
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DNA polmerase beta
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DNA polymerase
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DNA polymerase alpha
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DNA polymerase gamma
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-
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DNA polymerase I
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-
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DNA polymerase II
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-
-
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DNA polymerase III
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-
-
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DNA replicase
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-
-
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DNA-dependent DNA polymerase
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-
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duplicase
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-
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Klenow fragment
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-
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nucleotidyltransferase, deoxyribonucleate
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-
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Pol gamma
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-
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sequenase
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-
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Taq DNA polymerase
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-
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Taq Pol I
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Tca DNA polymerase
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
nucleotidyl group transfer
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-
-
-
SYSTEMATIC NAME
IUBMB Comments
deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed)
Catalyses DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time. Cannot initiate a chain de novo. Requires a primer, which may be DNA or RNA. See also EC 2.7.7.49 RNA-directed DNA polymerase.
CAS REGISTRY NUMBER
COMMENTARY hide
9012-90-2
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
a 2'-deoxyribonucleoside 5'-triphosphate + DNAn
diphosphate + DNAn+1
show the reaction diagram
-
-
-
?
deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
show the reaction diagram
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
a 2'-deoxyribonucleoside 5'-triphosphate + DNAn
diphosphate + DNAn+1
show the reaction diagram
-
-
-
?
deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
show the reaction diagram
-
-
-
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
aphidicolin
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alpha-like enzyme
N2-(p-n-butylphenyl)-2'-deoxyguanosine 5'-triphosphate
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alpha-like enzyme relatively resistant
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
drug target
the enzyme is a viable antimalarial drug target
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
Q9BHN0_PLAFA
1855
0
218984
TrEMBL
Secretory Pathway (Reliability: 1)
Q9TX75_PLAFA
1855
0
218984
TrEMBL
Secretory Pathway (Reliability: 1)
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
hanging drops method, crystal structure at a resolution of 2.9 A
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
alpha- and gamma-like DNA polymerase
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Chavalitshewinkoon, P.; De Vries, E.; Stam, J.G.; Franssen, F.F.J.; Van der Vliet, P.C.; Overdulve, J.P.
Purification and characterization of DNA polymerases from Plasmodium falciparum
Mol. Biochem. Parasitol.
61
243-253
1993
Plasmodium falciparum
Manually annotated by BRENDA team
Milton, M.E.; Choe, J.Y.; Honzatko, R.B.; Nelson, S.W.
Crystal structure of the apicoplast DNA polymerase from Plasmodium falciparum the first look at a plastidic A-family DNA polymerase
J. Mol. Biol.
428
3920-3934
2016
Plasmodium falciparum (Q8ILY1)
Manually annotated by BRENDA team