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EC Tree
IUBMB Comments Catalyses DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time. Cannot initiate a chain de novo. Requires a primer, which may be DNA or RNA. See also EC 2.7.7.49 RNA-directed DNA polymerase.
The taxonomic range for the selected organisms is: Plasmodium falciparum The enzyme appears in selected viruses and cellular organisms
Synonyms
dna polymerase alpha, dna polymerase beta, dna polymerase iii, pol beta, klenow fragment, dna polymerase delta, taq dna polymerase, pol delta, pol alpha, dna polymerase gamma,
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deoxynucleate polymerase
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deoxyribonucleate nucleotidyltransferase
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deoxyribonucleic acid duplicase
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deoxyribonucleic acid polymerase
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deoxyribonucleic duplicase
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deoxyribonucleic polymerase
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deoxyribonucleic polymerase I
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DNA nucleotidyltransferase
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DNA nucleotidyltransferase (DNA-directed)
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DNA polmerase beta
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DNA polymerase alpha
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DNA polymerase gamma
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DNA polymerase II
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DNA polymerase III
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DNA-dependent DNA polymerase
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nucleotidyltransferase, deoxyribonucleate
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Taq DNA polymerase
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Tca DNA polymerase
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nucleotidyl group transfer
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deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed)
Catalyses DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time. Cannot initiate a chain de novo. Requires a primer, which may be DNA or RNA. See also EC 2.7.7.49 RNA-directed DNA polymerase.
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a 2'-deoxyribonucleoside 5'-triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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a 2'-deoxyribonucleoside 5'-triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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aphidicolin
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alpha-like enzyme
N2-(p-n-butylphenyl)-2'-deoxyguanosine 5'-triphosphate
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alpha-like enzyme relatively resistant
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brenda
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UniProt
brenda
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brenda
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drug target
the enzyme is a viable antimalarial drug target
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Q9BHN0_PLAFA
1855
0
218984
TrEMBL
Secretory Pathway (Reliability: 1 )
Q9TX75_PLAFA
1855
0
218984
TrEMBL
Secretory Pathway (Reliability: 1 )
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hanging drops method, crystal structure at a resolution of 2.9 A
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alpha- and gamma-like DNA polymerase
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Chavalitshewinkoon, P.; De Vries, E.; Stam, J.G.; Franssen, F.F.J.; Van der Vliet, P.C.; Overdulve, J.P.
Purification and characterization of DNA polymerases from Plasmodium falciparum
Mol. Biochem. Parasitol.
61
243-253
1993
Plasmodium falciparum
brenda
Milton, M.E.; Choe, J.Y.; Honzatko, R.B.; Nelson, S.W.
Crystal structure of the apicoplast DNA polymerase from Plasmodium falciparum the first look at a plastidic A-family DNA polymerase
J. Mol. Biol.
428
3920-3934
2016
Plasmodium falciparum (Q8ILY1)
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