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EC Tree
IUBMB Comments Catalyses DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time. Cannot initiate a chain de novo. Requires a primer, which may be DNA or RNA. See also EC 2.7.7.49 RNA-directed DNA polymerase.
The taxonomic range for the selected organisms is: Gallus gallus The enzyme appears in selected viruses and cellular organisms
Synonyms
dna polymerase alpha, dna polymerase beta, dna polymerase iii, pol beta, klenow fragment, dna polymerase delta, taq dna polymerase, pol delta, pol alpha, dna polymerase gamma,
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deoxynucleate polymerase
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deoxyribonucleate nucleotidyltransferase
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deoxyribonucleic acid duplicase
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deoxyribonucleic acid polymerase
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deoxyribonucleic duplicase
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deoxyribonucleic polymerase
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deoxyribonucleic polymerase I
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DNA nucleotidyltransferase
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DNA nucleotidyltransferase (DNA-directed)
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DNA polmerase beta
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DNA polymerase alpha
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DNA polymerase gamma
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DNA polymerase II
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DNA polymerase III
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DNA-dependent DNA polymerase
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nucleotidyltransferase, deoxyribonucleate
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Taq DNA polymerase
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Tca DNA polymerase
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a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1
mechanism
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nucleotidyl group transfer
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deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed)
Catalyses DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time. Cannot initiate a chain de novo. Requires a primer, which may be DNA or RNA. See also EC 2.7.7.49 RNA-directed DNA polymerase.
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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DNA substrate: gapped duplex or single-stranded 5'-ends smaller than 100 nucleotides, pol I, pol II and pol III
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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beta-polymerase can copy a synthetic ribohomopolymer such as (A)n*(dT)12 as well as the corresponding deoxyribohomopolymer (dA)n*(dT)12 or activated DNA, alpha-polymerase utilizes the deoxyribohomopolymer (dA)n*dT12-18 eight times better than (A)n*dT12
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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overview: physiological roles in replication and in DNA repair synthesis
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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DNA polymerase gamma: required for mitochondrial DNA replication but encoded in the nucleus
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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overview: physiological roles in replication and in DNA repair synthesis
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deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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DNA polymerase gamma: required for mitochondrial DNA replication but encoded in the nucleus
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K+
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optimal concentration: 0.22 mM, DNA polymerase gamma
Mn2+
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stimulates at 0.5-0.6 mM, 5fold more effective than optimal Mg2+ concentration
Mg2+
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Mg2+
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stimulates at 12 mM, DNA polymerase gamma
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2-(p-n-Butylanilino)-2'-deoxyadenosine 5'-triphosphate
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DNA polymerase alpha
Carbonyldiphosphonate
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DNA polymerase delta; no inhibition of polymerase alpha
Dideoxynucleoside 5'-triphosphate
additional information
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no inhibition by dideoxynucleoside 5'-triphosphate; no inhibition of DNA polymerase beta and gamma by aphidicolin; no inhibition of DNA polymerase beta by N-ethylmaleimide; no inhibition of DNA polymerase beta, gamma, delta, epsilon by 2-(p-n-butylanilino)-2'-deoxyadenosine 5'-triphosphate; no inhibition of polymerase alpha and delta by dideoxynucleoside 5'-triphosphate
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aphidicolin
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DNA polymerase alpha; DNA polymerase delta; DNA polymerase epsilon
Dideoxynucleoside 5'-triphosphate
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DNA polymerase beta
Dideoxynucleoside 5'-triphosphate
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N-ethylmaleimide
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DNA polymerase alpha, gamma, delta
N-ethylmaleimide
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polymerase gamma
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proliferating cell nuclear antigen
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PCNA, specific auxiliary factor stimulating DNA polymerase delta
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Replication factor A
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RF-A, multisubunit single-stranded DNA-binding protein, functions as an auxiliary protein for both polymerases alpha and delta, required for initiation and elongation stages of in vitro SV40 DNA replication
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Replication factor C
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RF-C, multisubunit protein complex with primer/template binding and DNA-dependent ATPase activity, has a profound effect on leading-strand DNA synthesis
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8.5 - 9
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DNA polymerase gamma
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brenda
5 cellular DNA template-dependent DNA polymerases are encoded by distinct genes: polymerase alpha, i.e. pol I, polymerase beta, only in vertebrates, polymerase gamma, required for mitochondrial DNA replication but encoded in the nucleus, polymerase delta, enzymes in mammalian cell contain tightly associated 3'-5'-exonuclease activities, 2 forms: proliferating cell nuclear antigen-dependent and a proliferating cell nuclear antigen-independent, also called DNA polymerase delta II, now named DNA polymerase epsilon, polymerase epsilon, tightly associated 3'-5'-exonuclease activity, formerly named DNA polymerase delta II
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brenda
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DNA polymerase gamma
brenda
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DPOG1_CHICK
647
0
72855
Swiss-Prot
other Location (Reliability: 2 )
A0A1D5PGM5_CHICK
844
0
93744
TrEMBL
other Location (Reliability: 2 )
Q8AWW1_CHICK
867
0
97429
TrEMBL
other Location (Reliability: 1 )
A0A1D5PMZ6_CHICK
2875
0
324332
TrEMBL
other Location (Reliability: 2 )
A0A3Q2U842_CHICK
1487
0
170022
TrEMBL
other Location (Reliability: 2 )
F1NQT0_CHICK
3167
0
356631
TrEMBL
other Location (Reliability: 2 )
A0A1L1RQJ6_CHICK
181
0
20774
TrEMBL
other Location (Reliability: 1 )
A0A3Q2TZM6_CHICK
1496
0
170898
TrEMBL
other Location (Reliability: 2 )
A0A1L1RX75_CHICK
575
0
63793
TrEMBL
other Location (Reliability: 2 )
Q5F3Q4_CHICK
1128
0
128917
TrEMBL
other Location (Reliability: 1 )
F7B5D1_CHICK
606
0
66965
TrEMBL
other Location (Reliability: 2 )
Q59J86_CHICK
1462
0
167094
TrEMBL
other Location (Reliability: 1 )
F1P0C5_CHICK
1119
0
127440
TrEMBL
Mitochondrion (Reliability: 2 )
F1NR19_CHICK
1459
0
166559
TrEMBL
other Location (Reliability: 2 )
E1C5P2_CHICK
2290
0
260656
TrEMBL
other Location (Reliability: 1 )
A0A1D5PPC3_CHICK
2278
0
260870
TrEMBL
other Location (Reliability: 1 )
F1NMU1_CHICK
2489
0
276549
TrEMBL
other Location (Reliability: 5 )
A0A1L1RT70_CHICK
1191
0
135439
TrEMBL
Mitochondrion (Reliability: 2 )
A0A3Q2UHM0_CHICK
602
0
66552
TrEMBL
Mitochondrion (Reliability: 5 )
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180000
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DNA polymerase gamma, gel filtration and sedimentation experiments
40000
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vertebrates, DNA polymerase beta
47000
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4 * 47000, heterotetramer, DNA polymerase gamma
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tetramer
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4 * 47000, heterotetramer, DNA polymerase gamma
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Wang, T.S.F.
Eukaryotic DNA polymerases
Annu. Rev. Biochem.
60
513-552
1991
Bos taurus, Saccharomyces cerevisiae, Gallus gallus, Drosophila melanogaster, Homo sapiens, Mammalia, Rattus norvegicus, Xenopus laevis
brenda
Weissbach, A.
Cellular and viral-induced eukaryotic polymerases
The Enzymes,3rd Ed. (Boyer,P. D. ,ed. )
14
67-86
1981
Bos taurus, Gallus gallus, Herpes simplex virus, Homo sapiens, Mammalia, Mus musculus, Rattus norvegicus, Vaccinia virus
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brenda
Makarova, A.V.; Tarantul, V.Z.; Gening, L.V.
Evolution of DNA polymerase iota structure and function in eukaryotes
Biochemistry
73
346-352
2008
Canis lupus familiaris, Gallus gallus, Coturnix coturnix, Oryctolagus cuniculus, Misgurnus fossilis, Mus musculus, Rana temporaria, Rattus norvegicus, Triturus cristatus, Testudines agrionemys, Philothamnus punctatus
brenda