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Information on EC 2.7.7.7 - DNA-directed DNA polymerase and Organism(s) Arabidopsis thaliana

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EC Tree
     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.7 Nucleotidyltransferases
                2.7.7.7 DNA-directed DNA polymerase
IUBMB Comments
Catalyses DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time. Cannot initiate a chain de novo. Requires a primer, which may be DNA or RNA. See also EC 2.7.7.49 RNA-directed DNA polymerase.
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Arabidopsis thaliana
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Word Map
The taxonomic range for the selected organisms is: Arabidopsis thaliana
The enzyme appears in selected viruses and cellular organisms
Synonyms
dna polymerase alpha, dna polymerase beta, dna polymerase iii, pol beta, klenow fragment, dna polymerase delta, taq dna polymerase, pol delta, pol alpha, dna polymerase gamma, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ABO4/POL2a/TIL1
-
-
deoxynucleate polymerase
-
-
-
-
deoxyribonucleate nucleotidyltransferase
-
-
-
-
deoxyribonucleic acid duplicase
-
-
-
-
deoxyribonucleic acid polymerase
-
-
-
-
deoxyribonucleic duplicase
-
-
-
-
deoxyribonucleic polymerase
-
-
-
-
deoxyribonucleic polymerase I
-
-
-
-
DNA duplicase
-
-
-
-
DNA nucleotidyltransferase
-
-
-
-
DNA nucleotidyltransferase (DNA-directed)
-
-
-
-
DNA polmerase beta
-
-
-
-
DNA polymerase
-
-
-
-
DNA polymerase alpha
-
-
-
-
DNA polymerase delta
-
DNA polymerase epsilon
-
-
DNA polymerase eta
-
-
DNA polymerase gamma
-
-
-
-
DNA polymerase I
-
-
-
-
DNA polymerase II
-
-
-
-
DNA polymerase III
-
-
-
-
DNA replicase
-
-
-
-
DNA-dependent DNA polymerase
-
-
-
-
duplicase
-
-
-
-
Klenow fragment
-
-
-
-
nucleotidyltransferase, deoxyribonucleate
-
-
-
-
Pol gamma
-
-
-
-
POL2a
-
catalytic subunit of DNA polymerase epsilon
POLdelta1
catalytic subunit of the DNA polymerase delta
sequenase
-
-
-
-
Taq DNA polymerase
-
-
-
-
Taq Pol I
-
-
-
-
Tca DNA polymerase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
nucleotidyl group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed)
Catalyses DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time. Cannot initiate a chain de novo. Requires a primer, which may be DNA or RNA. See also EC 2.7.7.49 RNA-directed DNA polymerase.
CAS REGISTRY NUMBER
COMMENTARY hide
9012-90-2
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
show the reaction diagram
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
proliferating cell nuclear antigen
-
interaction with monoubiquitylated proliferating cell nuclear antigen is necessary for biological activity and is required for translesion synthesis past UV photoproducts by Poleta
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
-
abo4 mutants show early flowering and reduced expression of flowering locus C and increased expression of flowering locus T with changing histone H3 modifications
physiological function
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
DPOLA_ARATH
1524
0
170479
Swiss-Prot
other Location (Reliability: 4)
POLIA_ARATH
1050
0
117234
Swiss-Prot
Chloroplast (Reliability: 2)
POLIB_ARATH
1034
0
115563
Swiss-Prot
Mitochondrion (Reliability: 5)
POLK_ARATH
671
0
75252
Swiss-Prot
other Location (Reliability: 3)
DPOLL_ARATH
529
0
59588
Swiss-Prot
other Location (Reliability: 5)
REV3_ARATH
1890
0
210848
Swiss-Prot
other Location (Reliability: 4)
DPOD1_ARATH
1095
0
123236
Swiss-Prot
Mitochondrion (Reliability: 5)
POLH_ARATH
672
0
73985
Swiss-Prot
other Location (Reliability: 3)
DPOE1_ARATH
2161
0
248897
Swiss-Prot
other Location (Reliability: 2)
DPOE2_ARATH
2138
0
244993
Swiss-Prot
other Location (Reliability: 5)
DPOD2_ARATH
440
0
49410
Swiss-Prot
other Location (Reliability: 1)
F4HTM5_ARATH
1915
0
213748
TrEMBL
other Location (Reliability: 4)
A0A178W7B4_ARATH
1889
0
210786
TrEMBL
other Location (Reliability: 4)
A0A178WHY2_ARATH
157
0
18369
TrEMBL
Secretory Pathway (Reliability: 5)
A0A1P8AMQ2_ARATH
1629
0
181109
TrEMBL
other Location (Reliability: 4)
A0A654E847_ARATH
2161
0
248897
TrEMBL
other Location (Reliability: 2)
A0A5S9YHB3_ARATH
1095
0
123248
TrEMBL
Mitochondrion (Reliability: 5)
A0A178WEP0_ARATH
345
0
38581
TrEMBL
other Location (Reliability: 3)
A0A7G2EC39_ARATH
2124
0
243186
TrEMBL
other Location (Reliability: 5)
A0A7G2ET49_ARATH
407
0
44942
TrEMBL
Mitochondrion (Reliability: 1)
A0A384L5K4_ARATH
2114
0
243376
TrEMBL
other Location (Reliability: 2)
A0A7G2EQP6_ARATH
425
0
46757
TrEMBL
Mitochondrion (Reliability: 1)
A0A7G2E3Y5_ARATH
1744
0
194115
TrEMBL
other Location (Reliability: 4)
A8MQG8_ARATH
448
0
49270
TrEMBL
Mitochondrion (Reliability: 5)
A0A178W586_ARATH
529
0
59604
TrEMBL
other Location (Reliability: 5)
A0A1P8B2E1_ARATH
2141
0
245363
TrEMBL
other Location (Reliability: 5)
A0A1I9LTI3_ARATH
407
0
44875
TrEMBL
Mitochondrion (Reliability: 1)
A0A5S9WQF9_ARATH
1893
0
211325
TrEMBL
other Location (Reliability: 4)
A0A654E9R3_ARATH
529
0
59588
TrEMBL
other Location (Reliability: 5)
A0A178UHA5_ARATH
1524
0
170509
TrEMBL
other Location (Reliability: 4)
A0A5S9YIV3_ARATH
1524
0
170449
TrEMBL
other Location (Reliability: 4)
A0A178VT03_ARATH
2114
0
242861
TrEMBL
other Location (Reliability: 5)
A0A1P8AMN7_ARATH
1890
0
210889
TrEMBL
other Location (Reliability: 4)
F4KC69_ARATH
1112
0
125161
TrEMBL
Mitochondrion (Reliability: 5)
A0A7G2FL28_ARATH
1524
0
170479
TrEMBL
other Location (Reliability: 4)
A0A178W5U8_ARATH
487
0
55019
TrEMBL
other Location (Reliability: 5)
A0A178W8S6_ARATH
1906
0
212838
TrEMBL
other Location (Reliability: 4)
Q147H2_ARATH
425
0
46689
TrEMBL
Mitochondrion (Reliability: 1)
A0A178WI12_ARATH
2114
0
243376
TrEMBL
other Location (Reliability: 2)
A0A1I9LTI4_ARATH
430
0
47456
TrEMBL
Mitochondrion (Reliability: 5)
A0A178WHZ0_ARATH
2022
0
232785
TrEMBL
other Location (Reliability: 2)
A0A654FIE8_ARATH
430
0
47440
TrEMBL
Mitochondrion (Reliability: 5)
A0A7G2FIL7_ARATH
1072
0
120798
TrEMBL
other Location (Reliability: 5)
F4J5Q0_ARATH
365
0
40244
TrEMBL
Mitochondrion (Reliability: 5)
A0A654EWK3_ARATH
2142
0
245272
TrEMBL
other Location (Reliability: 5)
A0A5S9T906_ARATH
2012
0
231882
TrEMBL
other Location (Reliability: 2)
F4J5Q3_ARATH
413
0
45537
TrEMBL
Mitochondrion (Reliability: 1)
A0A654ELU2_ARATH
1889
0
210748
TrEMBL
other Location (Reliability: 4)
A0A1P8B2B9_ARATH
2139
0
245130
TrEMBL
other Location (Reliability: 5)
A0A178UA08_ARATH
1095
0
123236
TrEMBL
Mitochondrion (Reliability: 5)
A0A178V967_ARATH
247
0
27195
TrEMBL
other Location (Reliability: 5)
A0A1P8APE6_ARATH
487
0
55002
TrEMBL
other Location (Reliability: 5)
A0A1P8AMM8_ARATH
1889
0
210761
TrEMBL
other Location (Reliability: 4)
A0A5S9X1L3_ARATH
2041
0
234088
TrEMBL
other Location (Reliability: 5)
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
G534R
-
abscisic acid overly sensitive mutant, also hypersensitive to methyl methanesulfonate and UV-B light
additional information
-
null mutations in Arabidopsis POL2a are embryonic lethal
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
the downregulation of the POLdelta1 transcripts do not require an induction by alcohol
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Schuermann, D.; Fritsch, O.; Lucht, J.M.; Hohn, B.
Replication stress leads to genome instabilities in Arabidopsis DNA polymerase delta mutants
Plant Cell
21
2700-2714
2009
Arabidopsis thaliana (Q9LVN7), Arabidopsis thaliana
Manually annotated by BRENDA team
Yin, H.; Zhang, X.; Liu, J.; Wang, Y.; He, J.; Yang, T.; Hong, X.; Yang, Q.; Gong, Z.
Epigenetic regulation, somatic homologous recombination, and abscisic acid signaling are influenced by DNA polymerase epsilon mutation in Arabidopsis
Plant Cell
21
386-402
2009
Arabidopsis thaliana
Manually annotated by BRENDA team
Kunz, B.A.
A role for PCNA2 in translesion synthesis by Arabidopsis thaliana DNA polymerase eta
Plant Signal. Behav.
3
897-898
2008
Arabidopsis thaliana
Manually annotated by BRENDA team