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Information on EC 2.7.7.6 - DNA-directed RNA polymerase and Organism(s) Drosophila melanogaster

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EC Tree
     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.7 Nucleotidyltransferases
                2.7.7.6 DNA-directed RNA polymerase
IUBMB Comments
Catalyses DNA-template-directed extension of the 3'- end of an RNA strand by one nucleotide at a time. Can initiate a chain de novo. In eukaryotes, three forms of the enzyme have been distinguished on the basis of sensitivity to alpha-amanitin, and the type of RNA synthesized. See also EC 2.7.7.19 (polynucleotide adenylyltransferase) and EC 2.7.7.48 (RNA-directed RNA polymerase).
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Drosophila melanogaster
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Word Map
The taxonomic range for the selected organisms is: Drosophila melanogaster
The enzyme appears in selected viruses and cellular organisms
Synonyms
rna polymerase ii, pol ii, t7 rna polymerase, rna polymerase i, pol iii, rna polymerase iii, pol i, rnapii, rnap ii, dna-dependent rna polymerase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
C RNA formation factors
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-
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chloroplast soluble RNA polymerase
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-
-
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deoxyribonucleic acid-dependent ribonucleic acid polymerase
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-
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DNA-dependent ribonucleate nucleotidyltransferase
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-
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DNA-dependent RNA nucleotidyltransferase
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-
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DNA-dependent RNA polymerase
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-
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nucleotidyltransferase, ribonucleate
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-
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Pol II
ribonucleate nucleotidyltransferase
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-
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ribonucleate polymerase
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-
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ribonucleic acid formation factors, C
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-
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ribonucleic acid nucleotidyltransferase
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ribonucleic acid polymerase
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-
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ribonucleic acid transcriptase
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-
-
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ribonucleic polymerase
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-
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ribonucleic transcriptase
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-
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RNA formation factors, C
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RNA nucleotidyltransferase
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RNA nucleotidyltransferase (DNA-directed)
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-
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RNA polymerase
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-
-
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RNA polymerase I
-
-
-
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RNA polymerase II
RNA polymerase III
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-
-
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RNA transcriptase
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-
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RNAP
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-
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RNAP I
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-
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RNAP II
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RNAP III
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-
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transcriptase
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-
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-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
nucleotidyl group transfer
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-
-
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SYSTEMATIC NAME
IUBMB Comments
nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed)
Catalyses DNA-template-directed extension of the 3'- end of an RNA strand by one nucleotide at a time. Can initiate a chain de novo. In eukaryotes, three forms of the enzyme have been distinguished on the basis of sensitivity to alpha-amanitin, and the type of RNA synthesized. See also EC 2.7.7.19 (polynucleotide adenylyltransferase) and EC 2.7.7.48 (RNA-directed RNA polymerase).
CAS REGISTRY NUMBER
COMMENTARY hide
9014-24-8
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Spt6
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transcription factor, Pol II shows a broad requirement for essential Spt6 during different stages of development, e.g. for for maximal recruitment of Paf1 and Spt5 to transcriptionally active Hsp70. Spt6 interacts with both nucleosome structure and Pol II, it has a role in elongation, directed RNAi knock-down of Spt6 reduces the elongation rate, the Spt6-dependent effect on elongation rate persists during steady-state-induced transcription, reducing the elongation rate from about 1100 to 500 bp/min. Stimulation of Pol II elongation rate by Spt6 is not mediated through transcription factor TFIIS
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additional information
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the enzyme complex requires multiple transcription factors and protein interactions for activity, e.g. Spt6, overview
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
RPB1_DROME
1887
0
209168
Swiss-Prot
other Location (Reliability: 5)
RPA1_DROME
1642
0
185410
Swiss-Prot
other Location (Reliability: 4)
RPA2_DROME
1129
0
128444
Swiss-Prot
other Location (Reliability: 2)
RPB2_DROME
1176
0
134043
Swiss-Prot
other Location (Reliability: 1)
RPC2_DROME
1137
0
128515
Swiss-Prot
other Location (Reliability: 1)
I0EZ84_DROME
1410
0
157904
TrEMBL
other Location (Reliability: 4)
F6J9L9_DROME
267
0
30076
TrEMBL
other Location (Reliability: 1)
A0A0P0HG20_DROME
588
0
67119
TrEMBL
other Location (Reliability: 2)
A2VEV4_DROME
395
0
44284
TrEMBL
other Location (Reliability: 2)
A0A0P0H2M6_DROME
588
0
66974
TrEMBL
other Location (Reliability: 2)
A9UNH9_DROME
1887
0
209179
TrEMBL
other Location (Reliability: 5)
A0A0P0I6H8_DROME
588
0
67043
TrEMBL
other Location (Reliability: 2)
Q8SXM3_DROME
1429
0
157525
TrEMBL
Mitochondrion (Reliability: 4)
D0Z769_DROME
1887
0
209168
TrEMBL
other Location (Reliability: 5)
A0A0B4LI86_DROME
1176
0
134043
TrEMBL
other Location (Reliability: 1)
Q9VPW4_DROME
1369
0
156771
TrEMBL
Mitochondrion (Reliability: 2)
Q8MRK5_DROME
244
0
28562
TrEMBL
other Location (Reliability: 4)
A9YGC1_DROME
247
0
27855
TrEMBL
other Location (Reliability: 2)
A8JUY3_DROME
1383
0
154628
TrEMBL
other Location (Reliability: 4)
A9UN86_DROME
1410
0
157935
TrEMBL
other Location (Reliability: 4)
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ardehali, M.B.; Yao, J.; Adelman, K.; Fuda, N.J.; Petesch, S.J.; Webb, W.W.; Lis, J.T.
Spt6 enhances the elongation rate of RNA polymerase II in vivo
EMBO J.
28
1067-1077
2009
Drosophila melanogaster
Manually annotated by BRENDA team