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Information on EC 2.7.7.6 - DNA-directed RNA polymerase and Organism(s) Bos taurus

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EC Tree
     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.7 Nucleotidyltransferases
                2.7.7.6 DNA-directed RNA polymerase
IUBMB Comments
Catalyses DNA-template-directed extension of the 3'- end of an RNA strand by one nucleotide at a time. Can initiate a chain de novo. In eukaryotes, three forms of the enzyme have been distinguished on the basis of sensitivity to alpha-amanitin, and the type of RNA synthesized. See also EC 2.7.7.19 (polynucleotide adenylyltransferase) and EC 2.7.7.48 (RNA-directed RNA polymerase).
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Bos taurus
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The taxonomic range for the selected organisms is: Bos taurus
The enzyme appears in selected viruses and cellular organisms
Synonyms
rna polymerase ii, pol ii, t7 rna polymerase, rna polymerase i, pol iii, rna polymerase iii, pol i, rnapii, rnap ii, dna-dependent rna polymerase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
C RNA formation factors
-
-
-
-
chloroplast soluble RNA polymerase
-
-
-
-
deoxyribonucleic acid-dependent ribonucleic acid polymerase
-
-
-
-
DNA-dependent ribonucleate nucleotidyltransferase
-
-
-
-
DNA-dependent RNA nucleotidyltransferase
-
-
-
-
DNA-dependent RNA polymerase
-
-
-
-
nucleotidyltransferase, ribonucleate
-
-
-
-
Pol II
-
-
-
-
ribonucleate nucleotidyltransferase
-
-
-
-
ribonucleate polymerase
-
-
-
-
ribonucleic acid formation factors, C
-
-
-
-
ribonucleic acid nucleotidyltransferase
-
-
-
-
ribonucleic acid polymerase
-
-
-
-
ribonucleic acid transcriptase
-
-
-
-
ribonucleic polymerase
-
-
-
-
ribonucleic transcriptase
-
-
-
-
RNA formation factors, C
-
-
-
-
RNA nucleotidyltransferase
-
-
-
-
RNA nucleotidyltransferase (DNA-directed)
-
-
-
-
RNA polymerase
-
-
-
-
RNA polymerase I
-
-
-
-
RNA polymerase II
-
-
-
-
RNA polymerase III
-
-
-
-
RNA transcriptase
-
-
-
-
RNAP
-
-
-
-
RNAP I
-
-
-
-
RNAP II
-
-
-
-
RNAP III
-
-
-
-
transcriptase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
nucleotidyl group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed)
Catalyses DNA-template-directed extension of the 3'- end of an RNA strand by one nucleotide at a time. Can initiate a chain de novo. In eukaryotes, three forms of the enzyme have been distinguished on the basis of sensitivity to alpha-amanitin, and the type of RNA synthesized. See also EC 2.7.7.19 (polynucleotide adenylyltransferase) and EC 2.7.7.48 (RNA-directed RNA polymerase).
CAS REGISTRY NUMBER
COMMENTARY hide
9014-24-8
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
nucleoside triphosphate + RNAn
diphosphate + RNAn+1
show the reaction diagram
-
the enzyme requires DNA as template
-
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Tagetitoxin
-
no inhibition of calf thymus RNA polymerase II
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.05
-
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
RPC1_BOVIN
1390
0
155791
Swiss-Prot
other Location (Reliability: 2)
G3MZY8_BOVIN
1970
0
217192
TrEMBL
other Location (Reliability: 3)
B2WTN5_BOVIN
47
0
5508
TrEMBL
other Location (Reliability: 2)
A6QLS0_BOVIN
1135
0
128397
TrEMBL
other Location (Reliability: 4)
E1BIX2_BOVIN
1717
0
194119
TrEMBL
Mitochondrion (Reliability: 4)
A5PJW8_BOVIN
1174
0
133867
TrEMBL
other Location (Reliability: 1)
A0A3Q1M034_BOVIN
1010
0
115207
TrEMBL
other Location (Reliability: 1)
E1BPX6_BOVIN
1133
0
127813
TrEMBL
other Location (Reliability: 1)
A0A3Q1MCV3_BOVIN
1390
0
155812
TrEMBL
other Location (Reliability: 2)
E1BCZ0_BOVIN
1224
0
138102
TrEMBL
Mitochondrion (Reliability: 3)
Q5U8Z4_BOVIN
35
0
3967
TrEMBL
other Location (Reliability: 3)
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Weaver, R.F.; Blatti, S.P.; Rutter, W.J.
Molecular structures of DNA-dependent RNA polymerases (II) from calf thymus and rat liver
Proc. Natl. Acad. Sci. USA
68
2994-2999
1971
Bos taurus, Rattus norvegicus
Manually annotated by BRENDA team
Jacob, S.T.
Mammalian RNA polymerases
Prog. Nucleic Acid Res. Mol. Biol.
13
93-126
1973
Bos taurus, Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Steinberg, T.H.; Mathews, D.E.; Durbin, R.D.; Burgess, R.R.
Tagetitoxin: a new inhibitor of eukaryotic transcription by RNA polymerase III
J. Biol. Chem.
265
499-505
1990
Bombyx mori, Bos taurus, Saccharomyces cerevisiae, Homo sapiens, Xenopus laevis
Manually annotated by BRENDA team