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Information on EC 2.7.7.43 - N-acylneuraminate cytidylyltransferase and Organism(s) Homo sapiens

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EC Tree
IUBMB Comments
Acts on N-acetyl- and N-glycolyl- derivatives.
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This record set is specific for:
Homo sapiens
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The taxonomic range for the selected organisms is: Homo sapiens
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
cmp-sialic acid synthetase, cmp-neu5ac synthetase, cmp-neuac synthetase, cmp-n-acetylneuraminic acid synthetase, cmp-neunac synthetase, nmcss, cmp-sia synthetase, dmcss, cmp-sia-syn, dmcsas, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
acylneuraminate cytidyltransferase
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CMP sialate pyrophosphorylase
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CMP-N-acetylneuraminate synthase
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CMP-N-acetylneuraminate synthetase
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CMP-N-acetylneuraminic acid synthase
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CMP-N-acetylneuraminic acid synthetase
CMP-NANA synthetase
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CMP-Neu5Ac synthetase
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CMP-NeuAc synthetase
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CMP-NeuNAc synthetase
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CMP-Sia synthetase
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CMP-sialate synthase
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CMP-sialate synthetase
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-
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CMP-sialic acid synthetase
CMP-sialic synthetase
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CMPsialate pyrophosphorylase
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CMPsialate synthase
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cytidine 5'-monophospho-N-acetylneuraminic acid synthetase
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cytidine 5'-monophosphosialic acid synthetase
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cytidine 5-monophosphate N-acetylneuraminic acid synthetase
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cytidine monophosphate N-acetylneuraminic acid synthetase
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cytidine monophosphate-N-acetylneuraminic acid synthetase
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cytidine monophospho-sialic acid synthetase
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cytidine monophosphoacetylneuraminic synthetase
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cytidine monophosphosialate pyrophosphorylase
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cytidine monophosphosialate synthetase
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cytidyltransferase, acylneuraminate
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cytidylyltransferase, acetylneuraminate
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hCSS
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sialate cytidylyltransferase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
nucleotidyl group transfer
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-
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SYSTEMATIC NAME
IUBMB Comments
CTP:N-acylneuraminate cytidylyltransferase
Acts on N-acetyl- and N-glycolyl- derivatives.
CAS REGISTRY NUMBER
COMMENTARY hide
9067-82-7
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
show the reaction diagram
N-acetylneuraminic acid + CTP
CMP-NeuAc + diphosphate
show the reaction diagram
-
-
-
-
?
additional information
?
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the enzyme interacts with fragile X related protein 1
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
show the reaction diagram
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
4
CTP
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2.2
N-acetylneuraminate
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.045
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.5
-
assay at
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
37
-
assay at
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
the enzyme plays an important role in triple-negative breast cancer tumor formation and invasivity
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
NEUA_HUMAN
434
0
48379
Swiss-Prot
other Location (Reliability: 2)
Q53GF0_HUMAN
434
0
48329
TrEMBL
other Location (Reliability: 2)
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
partial
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Saccharomyces cerevisiae strain Y187
human CMP-N-acetylneuraminic acid synthetase is expressed in tobacco BY2 suspension-cultured cells, enzyme is demonstrated to be active
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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
enzyme expression is increased in triple-negative breast cancer
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
agriculture
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this approach enables plant cells to produce glycoproteins with mammalian-type N-glycans
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kean, E.L.; Roseman, S.
The sialic acids. X. Purification and properties of cytidine 5-monophosphosialic acid synthetase
J. Biol. Chem.
241
5643-5650
1966
Bos taurus, Ovis aries, Homo sapiens, Sus scrofa
Manually annotated by BRENDA team
Kolisis, F.N.
Studies on acylneuraminate cytidylytransferase from human placenta
Arch. Int. Physiol. Biochim.
92
179-184
1984
Homo sapiens
Manually annotated by BRENDA team
Bravo, I.G.; Reglero, A.
The cytidylyltransferases family: properties, kinetics, genomic and phylogeny: The cytidylyltransferases family: properties, kinetics, genomic and phylogeny
Recent Res. Devel. Biochem.
4
223-254
2003
Bos taurus, Escherichia coli, Equus caballus, [Haemophilus] ducreyi, Cricetinae, Erinaceidae, Homo sapiens, Mannheimia haemolytica, Neisseria meningitidis, Oncorhynchus mykiss, Rattus norvegicus, Streptococcus agalactiae, Sus scrofa
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Manually annotated by BRENDA team
Misaki, R.; Fujiyama, K.; Seki, T.
Expression of human CMP-N-acetylneuraminic acid synthetase and CMP-sialic acid transporter in tobacco suspension-cultured cell
Biochem. Biophys. Res. Commun.
339
1184-1189
2006
Homo sapiens
Manually annotated by BRENDA team
Ma, Y.; Tian, S.; Wang, Z.; Wang, C.; Chen, X.; Li, W.; Yang, Y.; He, S.
CMP-N-acetylneuraminic acid synthetase interacts with fragile X related protein 1
Mol. Med. Rep.
14
1501-1508
2016
Homo sapiens (Q8NFW8)
Manually annotated by BRENDA team
O Day, E.M.; Idos, G.E.; Hill, C.; Chen, J.W.; Wagner, G.
Cytidine monophosphate N-acetylneuraminic acid synthetase enhances invasion of human triple-negative breast cancer cells
OncoTargets Ther.
11
6827-6838
2018
Homo sapiens (Q8NFW8), Homo sapiens
Manually annotated by BRENDA team