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CTP + 1,2-diarachidonoyl-sn-phosphatidic acid
diphosphate + CDP-1,2-diarachidonoylglycerol
CTP + 1,2-dilinoleoyl-sn-phosphatidic acid
diphosphate + CDP-1,2-dilinoleoylglycerol
CTP + 1,2-dioleoyl-sn-phosphatidic acid
diphosphate + CDP-1,2-dioleoylglycerol
CTP + 1,2-diolinoleoyl-sn-phosphatidic acid
diphosphate + CDP-1,2-diolinoleoylglycerol
-
-
-
?
CTP + 1-palmitoyl-2-arachidonoyl-sn-phosphatidic acid
diphosphate + CDP-1-palmitoyl-2-arachidonoylglycerol
CTP + 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid
diphosphate + CDP-1-stearoyl-2-arachidonoyl-glycerol
-
-
-
?
CTP + 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid
diphosphate + CDP-1-stearoyl-2-arachidonoylglycerol
-
-
-
?
CTP + 1-stearoyl-2-docosahexaenoyl-sn-phosphatidic acid
diphosphate + CDP-1-stearoyl-2-docosahexaenoylglycerol
-
-
-
?
CTP + 1-stearoyl-2-linoleoyl-sn-phosphatidic acid
diphosphate + CDP-1-stearoyl-2-linoleoyl-glycerol
-
-
-
?
CTP + 1-stearoyl-2-linoleoyl-sn-phosphatidic acid
diphosphate + CDP-1-stearoyl-2-linoleoylglycerol
CTP + 1-stearoyl-2-oleoyl-sn-phosphatidic acid
diphosphate + CDP-1-stearoyl-2-oleoylglycerol
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
CTP + phosphatidate
diphosphate + CDPdiacylglycerol
dCTP + phosphatidate
diphosphate + dCDPdiacylglycerol
additional information
?
-
CTP + 1,2-diarachidonoyl-sn-phosphatidic acid
diphosphate + CDP-1,2-diarachidonoylglycerol
-
-
-
?
CTP + 1,2-diarachidonoyl-sn-phosphatidic acid
diphosphate + CDP-1,2-diarachidonoylglycerol
50% of the activity with 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid
-
-
?
CTP + 1,2-dilinoleoyl-sn-phosphatidic acid
diphosphate + CDP-1,2-dilinoleoylglycerol
-
-
-
?
CTP + 1,2-dilinoleoyl-sn-phosphatidic acid
diphosphate + CDP-1,2-dilinoleoylglycerol
20% of the activity with 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid
-
-
?
CTP + 1,2-dioleoyl-sn-phosphatidic acid
diphosphate + CDP-1,2-dioleoylglycerol
-
-
-
?
CTP + 1,2-dioleoyl-sn-phosphatidic acid
diphosphate + CDP-1,2-dioleoylglycerol
less than 5% of the activity with 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid
-
-
?
CTP + 1-palmitoyl-2-arachidonoyl-sn-phosphatidic acid
diphosphate + CDP-1-palmitoyl-2-arachidonoylglycerol
-
-
-
?
CTP + 1-palmitoyl-2-arachidonoyl-sn-phosphatidic acid
diphosphate + CDP-1-palmitoyl-2-arachidonoylglycerol
65% of the activity with 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid
-
-
?
CTP + 1-stearoyl-2-linoleoyl-sn-phosphatidic acid
diphosphate + CDP-1-stearoyl-2-linoleoylglycerol
-
-
-
?
CTP + 1-stearoyl-2-linoleoyl-sn-phosphatidic acid
diphosphate + CDP-1-stearoyl-2-linoleoylglycerol
20% of the activity with 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid
-
-
?
CTP + 1-stearoyl-2-oleoyl-sn-phosphatidic acid
diphosphate + CDP-1-stearoyl-2-oleoylglycerol
-
-
-
?
CTP + 1-stearoyl-2-oleoyl-sn-phosphatidic acid
diphosphate + CDP-1-stearoyl-2-oleoylglycerol
20% of the activity with 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid
-
-
?
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
-
-
-
?
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
-
-
-
?
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
-
-
-
?
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
-
-
-
?
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
isozyme CDS1 shows no particular substrate specificity, displaying similar activities for almost all substrates tested
-
-
?
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
isozyme CDS2 is selective for the acyl chains at the sn-1 and sn-2 positions, the most preferred species being 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid
-
-
?
CTP + phosphatidate
diphosphate + CDPdiacylglycerol
-
-
-
-
?
CTP + phosphatidate
diphosphate + CDPdiacylglycerol
-
-
-
?
CTP + phosphatidate
diphosphate + CDPdiacylglycerol
-
mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme
-
-
?
CTP + phosphatidate
diphosphate + CDPdiacylglycerol
the level of CDP-diacylglycerol synthetase 1 is not a critical determinant of cellular phosphatidylinositol content. This argues against a determining role of the activity in the regulation of phosphatidylinositol biosynthesis
-
-
?
dCTP + phosphatidate
diphosphate + dCDPdiacylglycerol
-
-
-
-
?
dCTP + phosphatidate
diphosphate + dCDPdiacylglycerol
-
mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme
-
-
?
additional information
?
-
CDS2 shows substrate specificity at both the sn-1 and sn-2 acyl chain positions. The most preferred substrate is 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid
-
-
?
additional information
?
-
CDS2 shows substrate specificity at both the sn-1 and sn-2 acyl chain positions. The most preferred substrate is 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid
-
-
?
additional information
?
-
-
CDS2 shows substrate specificity at both the sn-1 and sn-2 acyl chain positions. The most preferred substrate is 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid
-
-
?
additional information
?
-
isoform CDS1 appears to have no substrate preference for 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid, with variations of the sn-1 and sn-2 acyl chains resulting in no significant changes in preference
-
-
?
additional information
?
-
isoform CDS1 appears to have no substrate preference for 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid, with variations of the sn-1 and sn-2 acyl chains resulting in no significant changes in preference
-
-
?
additional information
?
-
-
isoform CDS1 appears to have no substrate preference for 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid, with variations of the sn-1 and sn-2 acyl chains resulting in no significant changes in preference
-
-
?
additional information
?
-
mixed micelle-based enzymatic activity with recombinant enzyme. Substrate specificity of CDS1, overview
-
-
?
additional information
?
-
mixed micelle-based enzymatic activity with recombinant enzyme. Substrate specificity of CDS1, overview
-
-
?
additional information
?
-
-
mixed micelle-based enzymatic activity with recombinant enzyme. Substrate specificity of CDS1, overview
-
-
?
additional information
?
-
mixed micelle-based enzymatic activity with recombinant enzyme. Substrate specificity of CDS2, overview
-
-
?
additional information
?
-
mixed micelle-based enzymatic activity with recombinant enzyme. Substrate specificity of CDS2, overview
-
-
?
additional information
?
-
-
mixed micelle-based enzymatic activity with recombinant enzyme. Substrate specificity of CDS2, overview
-
-
?
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CTP + 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid
diphosphate + CDP-1-stearoyl-2-arachidonoyl-glycerol
-
-
-
?
CTP + 1-stearoyl-2-linoleoyl-sn-phosphatidic acid
diphosphate + CDP-1-stearoyl-2-linoleoyl-glycerol
-
-
-
?
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
CTP + phosphatidate
diphosphate + CDPdiacylglycerol
dCTP + phosphatidate
diphosphate + dCDPdiacylglycerol
-
mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme
-
-
?
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
-
-
-
?
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
-
-
-
?
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
-
-
-
?
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
isozyme CDS1 shows no particular substrate specificity, displaying similar activities for almost all substrates tested
-
-
?
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
isozyme CDS2 is selective for the acyl chains at the sn-1 and sn-2 positions, the most preferred species being 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid
-
-
?
CTP + phosphatidate
diphosphate + CDPdiacylglycerol
-
mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme
-
-
?
CTP + phosphatidate
diphosphate + CDPdiacylglycerol
the level of CDP-diacylglycerol synthetase 1 is not a critical determinant of cellular phosphatidylinositol content. This argues against a determining role of the activity in the regulation of phosphatidylinositol biosynthesis
-
-
?
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L-alpha-phosphatidylinositol 4,5-bisphosphate
1 mol%, 80% inhibition; strongest inhibitor among the phosphatidylinositols tested
-
L-alpha-phosphatidylinositol 4-phosphate
1 mol%, 50% inhibition
-
phosphatidylinositol
15-20% inhibition by soybean and liver phosphatidylinositol, inhibition of CDS2 by phosphatidylinositol is acyl chain-dependent, with the strongest inhibition seen with the 1-stearoyl-2-arachidonoyl species; CDS1 shows no acyl chain-dependent inhibition; significant inhibition of isoform CDS2 by both soybean and liver PI, with 15?20% residual activity
phosphatidylinositol 4-phosphate
55% inhibition at 1 mol%
phosphatidylinositol-(4,5)-bisphosphate
80% inhibition at 1 mol%, CDS2 is inhibited by its anionic phospholipid end products, with phosphatidylinositol-(4,5)-bisphosphate showing the strongest inhibition; CDS1 is inhibited by their anionic phospholipid end products, with phosphatidylinositol-(4,5)-bisphosphate showing the strongest inhibition
additional information
no significant inhibition in activity when either soybean or liver phosphatidylinositol is used at equimolar concentrations with respect to substrate. Neither soy nor egg phosphatidylglycerol has any significant inhibitory effect when used at equimolar concentrations with respect to substrate. Isoform CDS1 shows no acyl chain-dependent inhibition for 1-stearoyl-2-arachidonoyl-snphosphatidylinositol, 1-stearoyl-2-linoleoyl-sn-phosphatidylinositol, or 1,2-diolinoleoyl-sn-phosphatidylinositol
-
additional information
no significant inhibition in activity when either soybean or liver phosphatidylinositol is used at equimolar concentrations with respect to substrate. Neither soy nor egg phosphatidylglycerol has any significant inhibitory effect when used at equimolar concentrations with respect to substrate. Isoform CDS1 shows no acyl chain-dependent inhibition for 1-stearoyl-2-arachidonoyl-snphosphatidylinositol, 1-stearoyl-2-linoleoyl-sn-phosphatidylinositol, or 1,2-diolinoleoyl-sn-phosphatidylinositol
-
additional information
-
no significant inhibition in activity when either soybean or liver phosphatidylinositol is used at equimolar concentrations with respect to substrate. Neither soy nor egg phosphatidylglycerol has any significant inhibitory effect when used at equimolar concentrations with respect to substrate. Isoform CDS1 shows no acyl chain-dependent inhibition for 1-stearoyl-2-arachidonoyl-snphosphatidylinositol, 1-stearoyl-2-linoleoyl-sn-phosphatidylinositol, or 1,2-diolinoleoyl-sn-phosphatidylinositol
-
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Carcinoma, Hepatocellular
Altered subcellular and submitochondrial localization of CTP:phosphatidate cytidylyltransferase in the Morris 7777 hepatoma.
Carcinoma, Hepatocellular
Methylation Inactivates Expression of CDP-diacylglycerol Synthase 1 (CDS1) in Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Phosphatidylserine biosynthesis in mitochondria from the Morris 7777 hepatoma.
Eye Diseases
Isolation and chromosomal localization of two human CDP-diacylglycerol synthase (CDS) genes.
Heart Defects, Congenital
TAMM41 is required for heart valve differentiation via regulation of PINK-PARK2 dependent mitophagy.
Infertility, Male
Reduced expression of CDP-DAG synthase changes lipid composition and leads to male sterility in Drosophila.
Retinal Degeneration
Isolation and characterization of murine Cds (CDP-diacylglycerol synthase) 1 and 2.
Retinal Degeneration
Isolation and chromosomal localization of two human CDP-diacylglycerol synthase (CDS) genes.
Starvation
Regulation of CDP-diacylglycerol synthesis and utilization by inositol and choline in Schizosaccharomyces pombe.
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additional information
1-stearoyl-2-arachidonoyl-sn-phosphatidic acid
-
additional information
1-stearoyl-2-arachidonoyl-sn-phosphatidic acid
Km value 0.8 mol%, pH 8.0, 22°C
-
additional information
1-stearoyl-2-arachidonoyl-sn-phosphatidic acid
Km value 0.8 mol%, pH 8.0, 22°C
-
additional information
1-stearoyl-2-arachidonoyl-sn-phosphatidic acid
-
Km value 0.8 mol%, pH 8.0, 22°C
-
additional information
1-stearoyl-2-arachidonoyl-sn-phosphatidic acid
Km value 1.4 mol%, pH 8.0, 22°C
-
additional information
1-stearoyl-2-arachidonoyl-sn-phosphatidic acid
Km value 1.4 mol%, pH 8.0, 22°C
-
additional information
1-stearoyl-2-arachidonoyl-sn-phosphatidic acid
-
Km value 1.4 mol%, pH 8.0, 22°C
-
additional information
1-stearoyl-2-linoleoyl-sn-phosphatidic acid
KM value 0.6 mol%, pH 8.0, 22°C
-
additional information
1-stearoyl-2-linoleoyl-sn-phosphatidic acid
KM value 0.6 mol%, pH 8.0, 22°C
-
additional information
1-stearoyl-2-linoleoyl-sn-phosphatidic acid
-
KM value 0.6 mol%, pH 8.0, 22°C
-
additional information
1-stearoyl-2-linoleoyl-sn-phosphatidic acid
KM value 0.9 mol%, pH 8.0, 22°C
-
additional information
1-stearoyl-2-linoleoyl-sn-phosphatidic acid
KM value 0.9 mol%, pH 8.0, 22°C
-
additional information
1-stearoyl-2-linoleoyl-sn-phosphatidic acid
-
KM value 0.9 mol%, pH 8.0, 22°C
-
additional information
additional information
0.8 mol% for 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid, 0.6 mol% for 1-stearoyl-2-linoleoyl-sn-phosphatidic acid, kinetics, overview
-
additional information
additional information
0.8 mol% for 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid, 0.6 mol% for 1-stearoyl-2-linoleoyl-sn-phosphatidic acid, kinetics, overview
-
additional information
additional information
-
0.8 mol% for 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid, 0.6 mol% for 1-stearoyl-2-linoleoyl-sn-phosphatidic acid, kinetics, overview
-
additional information
additional information
1.4 mol% for 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid, 0.9 mol% for 1-stearoyl-2-linoleoyl-sn-phosphatidic acid, kinetics, overview
-
additional information
additional information
1.4 mol% for 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid, 0.9 mol% for 1-stearoyl-2-linoleoyl-sn-phosphatidic acid, kinetics, overview
-
additional information
additional information
-
1.4 mol% for 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid, 0.9 mol% for 1-stearoyl-2-linoleoyl-sn-phosphatidic acid, kinetics, overview
-
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malfunction
knocking down CDS1 results in the formation of giant or supersized lipid droplets in cultured cells. The levels of many phosphatidate species are significantly increased upon knocking down CDS1, the amount of phosphatidate in the endoplasmic reticulum is dramatically increased upon knocking down CDS1, overview. The changes in phosphatidate level and localization may underlie the formation of giant lipid droplets as well as the block in adipogenesis in CDS-deficient cells
malfunction
knocking down CDS2 results in the formation of giant or supersized lipid droplets in cultured cells. Only a small number of phosphatidate species are increased upon depleting CDS2, the amount of phosphatidate in the endoplasmic reticulum is dramatically increased upon knocking down CDS2, overview. The changes in phosphatidate level and localization may underlie the formation of giant lipid droplets as well as the block in adipogenesis in CDS-deficient cells
malfunction
isoform CDS2 deficiency, but not isoform CDS1 deficiency, promotes the lipid droplet association of diacylglycerol-O-acyltransferase 2 and glycerol-3-phosphateacyltransferase 4 and impairs initial lipid droplet maturation
metabolism
the two isoforms of human CDS, CDS1 and CDS2, show different acyl chain specificities for its lipid substrate. CDS1 and CDS2 can create different CDP-DAG pools that may serve to enrich different phospholipid species with specific acyl chains
metabolism
the enzyme is critical for maintaining phosphoinositide levels during phospholipase C signaling
physiological function
isoforms CDS1 and CDS2 could create different CDP-diacylglycerol pools that may serve to enrich different phospholipid species with specific acyl chains. CDS1 shows no particular substrate specificity, displaying similar activities for almost all substrates tested, and shows no acyl chain-dependent inhibition. Both isoforms CDS1 and CDS2 are inhibited by their anionic phospholipid end products
physiological function
isoforms CDS1 and CDS2 could create different CDP-diacylglycerol pools that may serve to enrich different phospholipid species with specific acyl chains. CDS2 is selective for the acyl chains at the sn-1 and sn-2 positions, the most preferred species being 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid. Inhibition of CDS2 by phosphatidylinositol is also acyl chain-dependent, with the strongest inhibition seen with the 1-stearoyl-2-arachidonoyl species. Both isoforms CDS1 and CDS2 are inhibited by their anionic phospholipid end products
physiological function
CDP-diacylglycerol synthases (CDS) are critical enzymes that catalyze the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid
physiological function
CDP-diacylglycerol synthases regulate the growth of lipid droplets and adipocyte development, role of CDP-diacylglycerol in lipid storage in mammals. The expansion of lipid droplets and the differentiation of preadipocytes are two important aspects of mammalian lipid storage, CDS1 and CDS2 are important regulators of lipid storage
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Weeks, R.; Dowhan, W.; Shen, H.; Balantac, N.; Meengs, B.; Nudelman, E.; Leung, D.W.
Isolation and expression of an isoform of human CDP-diacylglycerol synthase cDNA
DNA Cell Biol.
16
281-289
1997
Homo sapiens
brenda
Heacock, A.M.; Agranoff, B.W.
CDP-diacylglycerol synthase from mammalian tissues
Biochim. Biophys. Acta
1348
166-172
1997
Cavia porcellus, Drosophila sp. (in: flies), Escherichia coli, Homo sapiens, Rattus norvegicus, Sus scrofa
brenda
Lykidis, A.; Jackson, P.; Rock, C.O.; Jackowski, S.
The role of CDP-diacylglycerol synthetase and phosphatidylinositol synthase activity levels in the regulation of cellular phosphatidylinositol content
J. Biol. Chem.
272
33402-33409
1997
Homo sapiens (Q92903), Homo sapiens
brenda
Waugh, M.G.; Minogue, S.; Clayton, E.L.; Hsuan, J.J.
CDP-diacylglycerol phospholipid synthesis in detergent-soluble, non-raft, membrane microdomains of the endoplasmic reticulum
J. Lipid Res.
52
2148-2158
2011
Homo sapiens
brenda
DSouza, K.; Kim, Y.J.; Balla, T.; Epand, R.M.
Distinct properties of the two isoforms of CDP-diacylglycerol synthase
Biochemistry
53
7358-7367
2014
Homo sapiens (O95674), Homo sapiens (Q92903), Homo sapiens
brenda
Qi, Y.; Kapterian, T.S.; Du, X.; Ma, Q.; Fei, W.; Zhang, Y.; Huang, X.; Dawes, I.W.; Yang, H.
CDP-diacylglycerol synthases regulate the growth of lipid droplets and adipocyte development
J. Lipid Res.
57
767-780
2016
Homo sapiens (O95674), Homo sapiens (Q92903), Mus musculus (P98191), Mus musculus (Q99L43)
brenda
Blunsom, N.J.; Cockcroft, S.
CDP-diacylglycerol synthases (CDS) gateway to phosphatidylinositol and cardiolipin synthesis
Front. Cell Dev. Biol.
8
63
2020
Aeropyrum pernix, Saccharomyces cerevisiae, Drosophila melanogaster, Schizosaccharomyces pombe, Streptococcus mitis, Streptococcus oralis, Thermotoga maritima, Toxoplasma gondii, Trypanosoma brucei brucei, Eimeria falciformis, Arabidopsis thaliana (O04928), Arabidopsis thaliana (O49639), Arabidopsis thaliana (Q1PE48), Arabidopsis thaliana (Q94A03), Arabidopsis thaliana (Q9M001), Escherichia coli (P0ABG1), Danio rerio (Q3B7H2), Homo sapiens (Q92903), Homo sapiens (Q95674)
brenda
Xu, Y.; Mak, H.Y.; Lukmantara, I.; Li, Y.E.; Hoehn, K.L.; Huang, X.; Du, X.; Yang, H.
CDP-DAG synthase 1 and 2 regulate lipid droplet growth through distinct mechanisms
J. Biol. Chem.
294
16740-16755
2019
Homo sapiens (O95674), Homo sapiens (Q92903)
brenda