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EC Tree
The taxonomic range for the selected organisms is: Homo sapiens
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
gdp-l-fucose pyrophosphorylase, atfkgp, gdp-l-fuc pyrophosphorylase, gdp-fucose pyrophosphorylase, l-fucokinase/gdp-fucose pyrophosphorylase, gdp-l-fucose-synthesizing enzymes, gdp-l-fucose pyrophosphorylase (fpgt), gtp fucose pyrophosphorylase (gfpp),
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GDP-fucose pyrophosphorylase
GDP-L-fucose pyrophosphorylase
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-
-
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GDPfucose pyrophosphorylase
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-
-
-
GTP fucose pyrophosphorylase
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-
GTP fucose pyrophosphorylase (GFPP)
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guanosine diphosphate L-fucose pyrophosphorylase
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-
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guanosine triphosphate fucose pyrophosphorylase (GFPP)
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GDP-fucose pyrophosphorylase
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-
-
-
GDP-fucose pyrophosphorylase
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-
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nucleotidyl group transfer
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-
-
-
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GTP:beta-L-fucose-1-phosphate guanylyltransferase
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2-amino-6-chloropurine-beta-D-riboside 5'-triphosphate + L-fucose 1-phosphate
diphosphate + 2-amino-6-chloropurine-beta-D-riboside 5'-(alpha-L-fucosyl)diphosphate
-
-
-
-
?
2-aminoadenosine triphosphate + L-fucose 1-phosphate
diphosphate + (2-aminoadenosine diphosphate)-L-fucose
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-
-
-
?
7-deazaguanosine triphosphate + L-fucose 1-phosphate
diphosphate + (7-deazaguanosine diphosphate)-L-fucose
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-
-
-
?
8-oxoguanosine triphosphate + L-fucose 1-phosphate
diphosphate + (8-oxoguanosine diphosphate)-L-fucose
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-
-
-
?
ATP + L-fucose 1-phosphate
diphosphate + ADP-L-fucose
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-
-
-
?
GTP + D-arabinose 1-phosphate
diphosphate + GDP-arabinose
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-
-
-
?
GTP + D-fructose 1-phosphate
diphosphate + GDP-fructose
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-
-
-
?
GTP + D-galactose 1-phosphate
diphosphate + GDP-galactose
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-
-
-
?
GTP + D-glucosamine 1-phosphate
diphosphate + GDP-glucosamine
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-
-
-
?
GTP + D-glucose 1,6-diphosphate
diphosphate + ?
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-
-
-
?
GTP + D-glucose 1-phosphate
diphosphate + GDP-glucose
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-
-
-
?
GTP + D-mannose 1-phosphate
diphosphate + GDP-mannose
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-
-
-
?
GTP + L-fucose 1-phosphate
diphosphate + GDP-L-fucose
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-
-
-
?
GTP + L-fucose 1-phosphate
GDP-L-fucose + diphosphate
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-
-
-
r
ITP + L-fucose 1-phosphate
diphosphate + IDP-L-fucose
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-
-
-
?
L-fucose 1-phosphate + GTP
GDP-L-fucose + diphosphate
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salvage pathway
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-
?
N1-methylguanosine triphosphate + L-fucose 1-phosphate
diphosphate + (N1-methylguanosine diphosphate)-L-fucose
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-
-
-
?
N2-methylguanosine triphosphate + L-fucose 1-phosphate
diphosphate + (N2-methylguanosine diphosphate)-L-fucose
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-
-
-
?
O6-methylguanosine triphosphate + L-fucose 1-phosphate
diphosphate + (O6-methylguanosine diphosphate)-L-fucose
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-
-
-
?
tricyclic guanosine triphosphate + L-fucose 1-phosphate
diphosphate + (tricyclic guanosine diphosphate)-L-fucose
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-
-
-
?
xanthosine triphosphate + L-fucose 1-phosphate
diphosphate + (xanthosine diphosphate)-L-fucose
-
-
-
-
?
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GTP + L-fucose 1-phosphate
GDP-L-fucose + diphosphate
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-
-
-
r
L-fucose 1-phosphate + GTP
GDP-L-fucose + diphosphate
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salvage pathway
-
-
?
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Neoplasms
Differential gene expression of GDP-L-fucose-synthesizing enzymes, GDP-fucose transporter and fucosyltransferase VII.
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0.163
2-amino-6-chloropurine-beta-D-riboside 5'-triphosphate
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pH 7.0, 37°C
0.21
2-aminoadenosine triphosphate
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pH 7.0, 37°C
0.0754
7-deazaguanosine triphosphate
-
pH 7.0, 37°C
0.0636
8-oxoguanosine triphosphate
-
pH 7.0, 37°C
0.0854
D-arabinose 1-phosphate
-
pH 7.0, 37°C
0.823
D-Fructose 1-phosphate
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pH 7.0, 37°C
0.677
D-galactose 1-phosphate
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pH 7.0, 37°C
0.828
D-glucosamine 1-phosphate
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pH 7.0, 37°C
0.621
D-glucose 1,6-diphosphate
-
pH 7.0, 37°C
0.346
D-glucose 1-phosphate
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pH 7.0, 37°C
0.542
D-mannose 1-phosphate
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pH 7.0, 37°C
0.0616
ITP
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pH 7.0, 37°C
0.067
L-fucose 1-phosphate
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pH 7.0, 37°C
0.423
N1-methylguanosine triphosphate
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pH 7.0, 37°C
1.263
N2-methylguanosine triphosphate
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pH 7.0, 37°C
0.121
O6-methylguanosine triphosphate
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pH 7.0, 37°C
0.232
tricyclic guanosine triphosphate
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pH 7.0, 37°C
0.823
xanthosine triphosphate
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pH 7.0, 37°C
0.0491
GTP
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pH 7.0, 37°C, mutant enzyme D427A
0.0496
GTP
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pH 7.0, 37°C, mutant enzyme E566A
0.0501
GTP
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pH 7.0, 37°C, mutant enzyme D299A
0.0502
GTP
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pH 7.0, 37°C
0.0502
GTP
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pH 7.0, 37°C, wild-type enzyme
0.0506
GTP
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pH 7.0, 37°C, mutant enzyme E574A
0.0511
GTP
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pH 7.0, 37°C, mutant enzyme K479A
0.0512
GTP
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pH 7.0, 37°C, mutant enzyme D184A
0.0522
GTP
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pH 7.0, 37°C, mutant enzyme K478A
0.0537
GTP
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pH 7.0, 37°C, mutant enzyme E289A
0.0805
GTP
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pH 7.0, 37°C, mutant enzyme E297A
0.127
GTP
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pH 7.0, 37°C, mutant enzyme E432A
0.289
GTP
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pH 7.0, 37°C, mutant enzyme D77A
0.422
GTP
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pH 7.0, 37°C, mutant enzyme E297A/E432A
0.633
GTP
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pH 7.0, 37°C, mutant enzyme K482A
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0.27
2-amino-6-chloropurine-beta-D-riboside 5'-triphosphate
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pH 7.0, 37°C
0.32
2-aminoadenosine triphosphate
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pH 7.0, 37°C
1.5
7-deazaguanosine triphosphate
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pH 7.0, 37°C
2.6
8-oxoguanosine triphosphate
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pH 7.0, 37°C
0.4
D-arabinose 1-phosphate
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pH 7.0, 37°C
0.03
fructose 1-phosphate
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pH 7.0, 37°C
0.23
Galactose 1-phosphate
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pH 7.0, 37°C
0.21
glucosamine 1-phosphate
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pH 7.0, 37°C
0.18
glucose 1,6-diphosphate
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pH 7.0, 37°C
0.32
glucose 1-phosphate
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pH 7.0, 37°C
3.6
L-fucose 1-phosphate
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pH 7.0, 37°C
0.2
mannose 1-phosphate
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pH 7.0, 37°C
0.02
N1-methylguanosine triphosphate
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pH 7.0, 37°C
0.009
N2-methylguanosine triphosphate
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pH 7.0, 37°C
0.09
O6-methylguanosine triphosphate
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pH 7.0, 37°C
0.29
tricyclic guanosine triphosphate
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pH 7.0, 37°C
0.03
xanthosine triphosphate
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pH 7.0, 37°C
0.001
GTP
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pH 7.0, 37°C, mutant enzyme D77A
0.001
GTP
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pH 7.0, 37°C, mutant enzyme E297A/E432A
0.05
GTP
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pH 7.0, 37°C, mutant enzyme E432A
0.19
GTP
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pH 7.0, 37°C, mutant enzyme K482A
0.2
GTP
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pH 7.0, 37°C, mutant enzyme E297A
2.2
GTP
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pH 7.0, 37°C, mutant enzyme K479A
2.3
GTP
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pH 7.0, 37°C, mutant enzyme K478A
2.4
GTP
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pH 7.0, 37°C, mutant enzyme E289A
2.4
GTP
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pH 7.0, 37°C, mutant enzyme E574A
2.5
GTP
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pH 7.0, 37°C, wild-type enzyme
2.6
GTP
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pH 7.0, 37°C, mutant enzyme D184A
2.6
GTP
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pH 7.0, 37°C, mutant enzyme D299A
2.6
GTP
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pH 7.0, 37°C, mutant enzyme D427A
2.6
GTP
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pH 7.0, 37°C, mutant enzyme E566A
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Uniprot
brenda
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-
-
brenda
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mRNA detected by northern analysis
brenda
mRNA detected by northern analysis
brenda
mRNA detected by northern analysis
brenda
mRNA detected by northern analysis
brenda
mRNA detected by northern analysis
brenda
mRNA detected by northern analysis
brenda
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-
brenda
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FPGT_HUMAN
607
0
68010
Swiss-Prot
Mitochondrion (Reliability: 2)
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hanging-drop vapor diffusion at 20°C
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D184A
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the ratio of turnover number to Km-value (for GTP) is 1.02fold higher than the wild-type ratio
D299A
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the ratio of turnover number to Km-value (for GTP) is 1.04fold higher than the wild-type ratio
D427A
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the ratio of turnover number to Km-value (for GTP) is 1.06fold lower than the wild-type ratio
D77A
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the ratio of turnover number to Km-value (for GTP) is 16600fold lower than the wild-type ratio
E289A
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the ratio of turnover number to Km-value (for GTP) is 1.1fold lower than the wild-type ratio
E297A
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the ratio of turnover number to Km-value (for GTP) is 19.5fold lower than the wild-type ratio
E297A/E432A
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the ratio of turnover number to Km-value (for GTP) is 24900fold lower than the wild-type ratio
E432A
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the ratio of turnover number to Km-value (for GTP) is 113fold lower than the wild-type ratio
E566A
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the ratio of turnover number to Km-value (for GTP) is 1.06fold higher than the wild-type ratio
E574A
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the ratio of turnover number to Km-value (for GTP) is 1.05fold lower than the wild-type ratio
K478A
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the ratio of turnover number to Km-value (for GTP) is 1.13fold lower than the wild-type ratio
K479A
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the ratio of turnover number to Km-value (for GTP) is 1.15fold lower than the wild-type ratio
K482A
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the ratio of turnover number to Km-value (for GTP) is 166fold lower than the wild-type ratio
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Pastuszak, I.; Ketchum, C.; Hermanson, G.; Sjoberg, E.J.; Drake, R.; Elbein, A.D.
GDP-L-fucose pyrophosphorylase. Purification, cDNA cloning, and properties of the enzyme
J. Biol. Chem.
273
30165-30174
1998
Cricetulus griseus, Homo sapiens (O14772), Homo sapiens, Sus scrofa
brenda
Quirk, S.; Seley, K.L.
Substrate discrimination by the human GTP fucose pyrophosphorylase
Biochemistry
44
10854-10863
2005
Homo sapiens
brenda
Quirk, S.; Seley, K.L.
Identification of catalytic amino acids in the human GTP fucose pyrophosphorylase active site
Biochemistry
44
13172-13178
2005
Homo sapiens
brenda
Quirk, S.; Seley-Radtke, K.L.
Purification, crystallization and preliminary X-ray characterization of the human GTP fucose pyrophosphorylase
Acta Crystallogr. Sect. F
62
392-394
2006
Homo sapiens
brenda
Moriwaki, K.; Noda, K.; Nakagawa, T.; Asahi, M.; Yoshihara, H.; Taniguchi, N.; Hayashi, N.; Miyoshi, E.
A high expression of GDP-fucose transporter in hepatocellular carcinoma is a key factor for increases in fucosylation
Glycobiology
17
1311-1320
2007
Homo sapiens
brenda
2.7.7.30 fucose-1-phosphate guanylyltransferase
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The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). 
