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Information on EC 2.7.7.15 - choline-phosphate cytidylyltransferase and Organism(s) Arabidopsis thaliana

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This record set is specific for:
Arabidopsis thaliana
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The taxonomic range for the selected organisms is: Arabidopsis thaliana
The enzyme appears in selected viruses and cellular organisms
Synonyms
ctp:phosphocholine cytidylyltransferase, cctalpha, ctalpha, phosphocholine cytidylyltransferase, pcyt1a, cholinephosphate cytidylyltransferase, cctbeta, choline-phosphate cytidylyltransferase, cctbeta2, ctp:phosphocholine cytidylyltransferase alpha, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
CCT
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CDP-choline pyrophosphorylase
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CDP-choline synthetase
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choline phosphate cytidylyltransferase
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CTP-phosphocholine cytidylyltransferase
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CTP:cholinephosphate cytidylyltransferase
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CTP:phosphocholine cytidylyltransferase
CTP:phosphorylcholine cytidylyltransferase
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CTP:phosphorylcholine cytidylyltransferase CCT1
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CTP:phosphorylcholine cytidylyltransferase CCT2
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cytidine diphosphocholine pyrophosphorylase
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cytidylyltransferase, choline phosphate
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phosphocholine cytidylyltransferase
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phosphorylcholine cytidylyltransferase
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phosphorylcholine transferase
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phosphorylcholine:CTP cytidylyltransferase
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additional information
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two different isoforms
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
nucleotidyl group transfer
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SYSTEMATIC NAME
IUBMB Comments
CTP:choline-phosphate cytidylyltransferase
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CAS REGISTRY NUMBER
COMMENTARY hide
9026-34-0
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
CTP + choline phosphate
diphosphate + CDP-choline
show the reaction diagram
CTP + phosphocholine
diphosphate + CDP-choline
show the reaction diagram
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?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
CTP + choline phosphate
diphosphate + CDP-choline
show the reaction diagram
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rate limiting enzyme for the synthesis of phosphatidylcholine, inhibition of CCT triggers apoptosis, involved in cold acclimation
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?
CTP + phosphocholine
diphosphate + CDP-choline
show the reaction diagram
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?
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Lipids
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regulation of activity by reversible association with membrane lipids
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pI VALUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
3.79
calculated from sequence
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
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enzyme is activated when bound to vesicles
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
CCT1_ARATH
332
0
38486
Swiss-Prot
other Location (Reliability: 3)
CCT2_ARATH
304
0
34983
Swiss-Prot
other Location (Reliability: 2)
A0A7G2F2K3_ARATH
268
0
30628
TrEMBL
other Location (Reliability: 2)
Q42555_ARATH
331
0
38418
TrEMBL
other Location (Reliability: 2)
A0A1P8AXC2_ARATH
283
0
33508
TrEMBL
Mitochondrion (Reliability: 5)
A0A384KL63_ARATH
332
0
38486
TrEMBL
other Location (Reliability: 3)
A0A178V0Z3_ARATH
305
0
35081
TrEMBL
other Location (Reliability: 2)
A0A178VQG6_ARATH
332
0
38486
TrEMBL
other Location (Reliability: 3)
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phosphoprotein
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
overexpression of the CTP:phosphocholine cytidylyltransferase (AtCCT1) catalytic domain in Nicotiana benthamiana leaves increased phosphatidylcholine content, and sucrose nonfermenting 1-related protein kinase 1 (SnRK1) co-expression reduces this effect
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
at low temperature
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Jackowski, S.; Fagone, P.
CTP:phosphocholine cytidylyltransferase: Paving the way from gene to membrane
J. Biol. Chem.
280
853-856
2005
Arabidopsis thaliana, Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Inatsugi, R.; Kawai, H.; Yamaoka, Y.; Yu, Y.; Sekiguchi, A.; Nakamura, M.; Nishida, I.
Isozyme-specific modes of activation of CTP:phosphorylcholine cytidylyltransferase in Arabidopsis thaliana at low temperature
Plant Cell Physiol.
50
1727-1735
2009
Arabidopsis thaliana
Manually annotated by BRENDA team
Caldo, K.M.P.; Xu, Y.; Falarz, L.; Jayawardhane, K.; Acedo, J.Z.; Chen, G.
Arabidopsis CTP phosphocholine cytidylyltransferase 1 is phosphorylated and inhibited by sucrose nonfermenting 1-related protein kinase 1 (SnRK1)
J. Biol. Chem.
294
15862-15874
2019
Arabidopsis thaliana (Q9ZV56)
Manually annotated by BRENDA team